Yoshihiko Saito

Summary

Affiliation: Nara Medical University
Country: Japan

Publications

  1. doi request reprint Roles of guanylyl cyclase--a signaling in the cardiovascular system
    Yoshihiko Saito
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Can J Physiol Pharmacol 89:551-6. 2011
  2. pmc Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate: subanalysis from the JPAD trial
    Yoshihiko Saito
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Diabetes Care 34:280-5. 2011
  3. doi request reprint Roles of atrial natriuretic peptide and its therapeutic use
    Yoshihiko Saito
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Cardiol 56:262-70. 2010
  4. ncbi request reprint Clinical pathology and treatment of renin-angiotensin system 1. Usefulness of blocking of the renin-angiotensin system in treatment of chronic heart failure
    Yoshihiko Saito
    The First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Intern Med 46:1291-4. 2007
  5. doi request reprint Fractalkine expression and CD16+ monocyte accumulation in glomerular lesions: association with their severity and diversity in lupus models
    Kimihiko Nakatani
    First Dept of Internal Medicine, Nara Medical Univ, 840, Shijo cho, Kashihara, Nara, 634 8522, Japan
    Am J Physiol Renal Physiol 299:F207-16. 2010
  6. ncbi request reprint Treatment with recombinant placental growth factor (PlGF) enhances both angiogenesis and arteriogenesis and improves survival after myocardial infarction
    Yukiji Takeda
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Circ J 73:1674-82. 2009
  7. ncbi request reprint Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Hypertens Res 29:493-7. 2006
  8. ncbi request reprint Long-term follow-up of neointimal coverage of sirolimus-eluting stents--evaluation with optical coherence tomography
    Ken ichi Ishigami
    First Department of Medicine, Nara Medical University, Kashihara, Japan
    Circ J 73:2300-7. 2009
  9. ncbi request reprint An elevated ratio of placental growth factor to soluble fms-like tyrosine kinase-1 predicts adverse outcomes in patients with stable coronary artery disease
    Takaki Matsumoto
    The First Department of Internal Medicine, Nara Medical University, Japan
    Intern Med 52:1019-27. 2013
  10. doi request reprint Prognostic value of B-type natriuretic peptide and its amino-terminal proBNP fragment for cardiovascular events with stratification by renal function
    Manabu Horii
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    J Cardiol 61:410-6. 2013

Detail Information

Publications109 found, 100 shown here

  1. doi request reprint Roles of guanylyl cyclase--a signaling in the cardiovascular system
    Yoshihiko Saito
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Can J Physiol Pharmacol 89:551-6. 2011
    ..Roles of endogenous ANP and BNP have been investigated using mice lacking the gene encoding GC-A. Here we describe the recent understanding of roles of GC-A in the cardiovascular system...
  2. pmc Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate: subanalysis from the JPAD trial
    Yoshihiko Saito
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Diabetes Care 34:280-5. 2011
    ..The purpose of this study was to investigate the efficacy of low-dose aspirin therapy on primary prevention of atherosclerotic events in patients with type 2 diabetes and coexisting renal dysfunction...
  3. doi request reprint Roles of atrial natriuretic peptide and its therapeutic use
    Yoshihiko Saito
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Cardiol 56:262-70. 2010
    ..Therefore, this review focuses on the recent clinical evidence of ANP in therapeutic use and experimental data that rationally support the therapeutic use of ANP...
  4. ncbi request reprint Clinical pathology and treatment of renin-angiotensin system 1. Usefulness of blocking of the renin-angiotensin system in treatment of chronic heart failure
    Yoshihiko Saito
    The First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Intern Med 46:1291-4. 2007
  5. doi request reprint Fractalkine expression and CD16+ monocyte accumulation in glomerular lesions: association with their severity and diversity in lupus models
    Kimihiko Nakatani
    First Dept of Internal Medicine, Nara Medical Univ, 840, Shijo cho, Kashihara, Nara, 634 8522, Japan
    Am J Physiol Renal Physiol 299:F207-16. 2010
    ..Taken together, our findings suggest that Fkn and CD16(+) Mo accumulation are partially associated with the severity and diversity of histology of lupus nephritis...
  6. ncbi request reprint Treatment with recombinant placental growth factor (PlGF) enhances both angiogenesis and arteriogenesis and improves survival after myocardial infarction
    Yukiji Takeda
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Circ J 73:1674-82. 2009
    ..However, the effects of exogenous PlGF administration on the healing process after MI are not fully understood. The purpose of the present study was to examine whether PlGF treatment has therapeutic potential in MI...
  7. ncbi request reprint Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Hypertens Res 29:493-7. 2006
    ....
  8. ncbi request reprint Long-term follow-up of neointimal coverage of sirolimus-eluting stents--evaluation with optical coherence tomography
    Ken ichi Ishigami
    First Department of Medicine, Nara Medical University, Kashihara, Japan
    Circ J 73:2300-7. 2009
    ..The time course of neointimal growth and risk factors of uncovered stent struts after sirolimus-eluting stent (SES) was studied using optical coherence tomography (OCT)...
  9. ncbi request reprint An elevated ratio of placental growth factor to soluble fms-like tyrosine kinase-1 predicts adverse outcomes in patients with stable coronary artery disease
    Takaki Matsumoto
    The First Department of Internal Medicine, Nara Medical University, Japan
    Intern Med 52:1019-27. 2013
    ..Both PlGF and sFlt-1 play important roles in the pathological mechanisms of atherosclerosis. We recently demonstrated that the plasma levels of these molecules are correlated with the severity of coronary atherosclerosis...
  10. doi request reprint Prognostic value of B-type natriuretic peptide and its amino-terminal proBNP fragment for cardiovascular events with stratification by renal function
    Manabu Horii
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    J Cardiol 61:410-6. 2013
    ..Both of these peptides are elevated in patients with chronic kidney disease (CKD), but there is no evidence as to which peptide is the more suitable biomarker in patients with severe renal dysfunction...
  11. doi request reprint Clinical significance of fibroblast-specific protein-1 expression on podocytes in patients with focal segmental glomerulosclerosis
    Ken ichi Samejima
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Nephron Clin Pract 120:c1-7. 2012
    ..The EMT-like changes observed in podocytes are reportedly associated with podocyte detachment which may cause focal glomerulosclerosis...
  12. pmc Major risk factors for the appearance of white-matter lesions on MRI in hypertensive patients with controlled blood pressure
    Takeshi Takami
    Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan
    Vasc Health Risk Manag 8:169-76. 2012
    ..We investigated the relationships of the presence of WMLs with the central systolic BP (cSBP) and estimated glomerular filtration rate (eGFR) in treated hypertensive patients...
  13. doi request reprint Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis
    Kenji Onoue
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522 Japan
    Circulation 120:2470-7. 2009
    ....
  14. doi request reprint Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis
    Kuniko Kimura
    First Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara 634 8522, Japan
    Am J Physiol Renal Physiol 295:F1023-9. 2008
    ..In conclusion, HIF-1alpha appears to be a critical contributor to the progression of renal fibrosis and could be a useful target for its treatment...
  15. ncbi request reprint Dual-single photon emission computed tomography and contrast-enhanced magnetic resonance imaging to evaluate dissimilar features of apical hypertrophic cardiomyopathy
    Satoshi Okayama
    Nara Medical University, First Department of Internal Medicine, Nara, Japan
    Cardiol J 17:306-11. 2010
    ..These dissimilar findings in dual-SPECT might be important in identifying patients with apical HCM who are at high risk of forming aneurysms...
  16. doi request reprint Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis
    Yasuhiro Takemoto
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Arterioscler Thromb Vasc Biol 29:857-62. 2009
    ..We tested the hypothesis that local delivery of human placental E-NTPDase (pE-NTPDase) gene into injured arteries via gene-eluting stent could prevent subacute in-stent thrombosis...
  17. doi request reprint Usefulness of soluble Fms-like tyrosine kinase-1 as a biomarker of acute severe heart failure in patients with acute myocardial infarction
    Kenji Onoue
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Am J Cardiol 104:1478-83. 2009
    ..In conclusion, the circulating level of sFlt-1 is increased in patients with acute MI, and the sFlt-1 level on admission is a promising biomarker for the development of severe acute heart failure after MI...
  18. doi request reprint The specific mineralocorticoid receptor blocker eplerenone attenuates left ventricular remodeling in mice lacking the gene encoding guanylyl cyclase-A
    Qingfen Zhang
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Hypertens Res 31:1251-6. 2008
    ..In conclusion, eplerenone attenuates cardiac remodeling in GC-A KO mice, most likely in a blood pressure-independent manner, which suggests that signaling downstream of MR is involved in the ventricular remodeling of GC-A KO mice...
  19. pmc Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor
    Satoshi Somekawa
    The First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634, Japan
    Endocrinology 150:3110-7. 2009
    ..In conclusion, NRSF/NRSE controls aldosterone and cortisol synthesis by regulating CYP11B2 and CYP11B1 gene transcription mainly through NRSF/NRSE-mediated enhancement of the CACNA1H gene...
  20. doi request reprint Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy
    Yukinari Yamaguchi
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Am J Kidney Dis 54:653-64. 2009
    ....
  21. ncbi request reprint Inflammatory response to acute myocardial infarction augments neointimal hyperplasia after vascular injury in a remote artery
    Minoru Takaoka
    First Department of Internal Medicine, Nara Medical University, 84 Shijo cho, Kashihara, Nara 634 8522, Japan
    Arterioscler Thromb Vasc Biol 26:2083-9. 2006
    ....
  22. doi request reprint Optimization of energy level for coronary angiography with dual-energy and dual-source computed tomography
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Int J Cardiovasc Imaging 28:901-9. 2012
    ..6% in PEIs (P < 0.0001) and by 18.2% in MEIs (P < 0.05), compared with 120-kVp composite images. The image quality of coronary angiography using DE-CT can be improved by optimizing the energy level for individual patients...
  23. doi request reprint Novel application of black-blood echo-planar imaging to the assessment of myocardial infarction
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Heart Vessels 25:104-12. 2010
    ..However, BB-EPI sometimes shows an inconsistent signal area with T2WI specifically in posterior wall. The wide practical use of BB-EPI requires the solution to this serious problem...
  24. pmc Differential effect of low-dose aspirin for primary prevention of atherosclerotic events in diabetes management: a subanalysis of the JPAD trial
    Sadanori Okada
    First Department of Internal Medicine, Nara Medical University, Shijo cho, Kashihara, Nara, Japan
    Diabetes Care 34:1277-83. 2011
    ..We hypothesized that low-dose aspirin would be beneficial in patients receiving insulin therapy, as a high-risk group...
  25. ncbi request reprint Progression of non-culprit coronary artery atherosclerosis after acute myocardial infarction in comparison with stable angina pectoris
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    J Atheroscler Thromb 15:228-34. 2008
    ..The present study assessed the progression of luminal narrowing of non-culprit coronary arteries (NCCA) in patients following AMI...
  26. doi request reprint Prediction of corticosteroid responsiveness based on fibroblast-specific protein 1 (FSP1) in patients with IgA nephropathy
    Koji Harada
    1st Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara 634 8522, Japan
    Nephrol Dial Transplant 23:3152-9. 2008
    ..The purpose of this study is to determine the extent to which fibroblast-specific protein 1-positive (FSP1(+)) cells are predictive of corticosteroid responsiveness in patients with IgAN...
  27. doi request reprint Thin-cap fibroatheroma and microchannel findings in optical coherence tomography correlate with subsequent progression of coronary atheromatous plaques
    Shiro Uemura
    First Department of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 0813, Japan
    Eur Heart J 33:78-85. 2012
    ..The aim of this study was to clarify the morphological characteristics of NSCPs in patients with coronary artery disease (CAD) using intravascular optical coherence tomography (OCT)...
  28. doi request reprint Morphological features of coronary arteries in patients with coronary spastic angina: assessment with intracoronary optical coherence tomography
    Yoshinobu Morikawa
    First Department of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Int J Cardiol 146:334-40. 2011
    ..We evaluate the morphological characteristics of coronary arteries in patients with coronary spastic angina (CSA) using intravascular optical coherence tomography (OCT)...
  29. doi request reprint Cardiac Raynaud's phenomenon induced by cold provocation as a predictor of long-term left ventricular dysfunction and remodelling in systemic sclerosis: 7-year follow-up study
    Reiko Mizuno
    Department of General Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara 634 8522, Japan
    Eur J Heart Fail 12:268-75. 2010
    ..This prospective study investigated the impact of C-Raynaud on long-term irreversible left ventricular (LV) functional and morphologic deterioration in SSc...
  30. doi request reprint A new drug delivery system for intravenous coronary thrombolysis with thrombus targeting and stealth activity recoverable by ultrasound
    Hiroyuki Kawata
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    J Am Coll Cardiol 60:2550-7. 2012
    ..The purpose of this study was to develop a new intelligent drug delivery system for intracoronary thrombolysis with a strong thrombolytic effect without increasing bleeding risk...
  31. ncbi request reprint [Case of purpura nephritis accompanied by idiopathic cholesterol embolism]
    Hirokazu Sakan
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Nihon Jinzo Gakkai Shi 54:622-8. 2012
    ..In this case, renal dysfunction may be related to the ischemic interstitial damage caused by cholesterol crystal embolism, as well as purpura nephritis...
  32. doi request reprint Contrast-enhanced computed tomographic and echocardiographic detection of intra-aortic floating thrombus causing acute myocardial infarction
    Tsunenari Soeda
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Cardiovasc Comput Tomogr 5:63-5. 2011
    ..A stent was implanted to prevent the mass from sealing the LMCA ostium, but the patient died of sepsis. A post-mortem examination clarified that the mass was a red thrombus attached to an erosive and atherosclerotic aortic wall...
  33. ncbi request reprint Surrogate markers of insulin resistance in assessing individuals with new categories "prehypertension" and "prediabetes"
    Masao Kanauchi
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Clin Chem Lab Med 45:35-9. 2007
    ..The aim of this study was to examine associations of surrogate markers of insulin resistance with PHT/PDM...
  34. ncbi request reprint High mean corpuscular volume is a new indicator of prognosis in acute decompensated heart failure
    Tomoya Ueda
    First Department of Internal Medicine, Nara Medical University
    Circ J 77:2766-71. 2013
    ..The prognostic implication of mean corpuscular volume (MCV) in HF, however, is unknown. In this context, we investigated the relationship between MCV and prognosis of acute decompensated HF (ADHF)...
  35. ncbi request reprint Effect of low-dose aspirin on primary prevention of cardiovascular events in Japanese diabetic patients at high risk
    Sadanori Okada
    First Department of Internal Medicine, Nara Medical University
    Circ J 77:3023-8. 2013
    ..We evaluated aspirin's benefit in Japanese diabetic patients stratified by cardiovascular risk...
  36. doi request reprint Optimal antihypertensive level for improvement of coronary microvascular dysfunction: the lower, the better?
    Reiko Mizuno
    Central Clinical Laboratory, Nara Medical University, 634 8522, 840 Shijo, Kashihara, Nara, Japan
    Hypertension 60:326-32. 2012
    ..Furthermore, raising diastolic blood pressure to a higher level within normal range has the most beneficial effect. However, as this study is based on observational design, it may have several limitations...
  37. doi request reprint Non-contact mapping system accurately localizes right-sided accessory pathways in type B Wolff-Parkinson-White syndrome
    Taku Nishida
    The First Department of Internal Medicine, Nara Medical University, Shijocho 840, Kashihara, Nara 634 8521, Japan
    Europace 14:752-60. 2012
    ..This study investigated the electrophysiological characteristics and efficacy of a non-contact mapping (NCM) system for catheter ablation of right-sided APs...
  38. doi request reprint Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion
    Osamu Asai
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Kidney Int 81:539-47. 2012
    ..Thus, α-Klotho expression was decreased in distal convoluted tubules in diabetic nephropathy in humans and mice. Renal loss of α-Klotho may affect urinary calcium excretion in early diabetic nephropathy...
  39. pmc Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population
    Atsushi Kubo
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    PLoS ONE 6:e24058. 2011
    ....
  40. doi request reprint Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation
    Manabu Horii
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, 634 8521, Japan
    Heart Vessels 23:301-7. 2008
    ....
  41. ncbi request reprint Ultrasound accelerates thrombolysis of acutely induced platelet-rich thrombi similar to those in acute myocardial infarction
    Hiroyuki Kawata
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara 634 8522, Japan
    Circ J 71:1643-8. 2007
    ..The effects of adding ultrasound (US) to pharmacological lysis of platelet-rich thrombi was examined in a rabbit model of femoral artery occlusion...
  42. doi request reprint Exercise-induced delayed onset of left ventricular early relaxation in association with coronary microcirculatory dysfunction in patients with diabetes mellitus
    Reiko Mizuno
    Department of General Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara, Japan
    J Card Fail 16:211-7. 2010
    ..Diabetes mellitus (DM) is known to be associated with coronary microangiopathy, but its influence on LV early relaxation is not established...
  43. ncbi request reprint Utility of elevated 2-hour postload plasma glucose as an alternative to elevated fasting glucose as a criterion for the metabolic syndrome
    Masao Kanauchi
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 0813, Japan
    Metabolism 55:1323-6. 2006
    ..On the other hand, there was no statistical difference in the values between PCH-MS and NCEP-MS. Our data support the addition of abnormal 2-hour plasma glucose as a criterion for the MS, when fasting glucose is normal...
  44. ncbi request reprint Atrial right-to-left shunt without pulmonary hypertension in a patient with biventricular non-compaction cardiomyopathy accompanied by ventricular and atrial septal defects
    Hirokazu Sakan
    The First Department of Internal Medicine, Nara Medical University, Japan
    Intern Med 50:1747-51. 2011
    ..We considered that the atrial right-to-left shunt had induced the hypoxemia, which was related mainly to right ventricular dysfunction in this biventricular non-compaction cardiomyopathy, but it was not related to pulmonary hypertension...
  45. doi request reprint Clinical significance of papillary muscle late enhancement detected via cardiac magnetic resonance imaging in patients with single old myocardial infarction
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Int J Cardiol 146:73-9. 2011
    ..Contrast-enhanced cardiac magnetic resonance imaging (MRI) can depict papillary muscle (PM) necrosis or fibrosis by late enhancement (LE) of PM, but its clinical significance in old myocardial infarction (OMI) has been little understood...
  46. ncbi request reprint Dual gradient-echo in-phase and opposed-phase magnetic resonance imaging to evaluate lipomatous metaplasia in patients with old myocardial infarction
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Magn Reson Med Sci 9:85-9. 2010
    ..The areas of lipomatous metaplasia measured by IPOP-MRI with ECG gating correlated well with those areas on black-blood T(1)-weighted imaging (r=0.82, P<0.0001, mean bias-0.29 cm(2), limit of agreement+/-2.06 cm(2))...
  47. doi request reprint Diagnostic accuracy of dual-source computed tomography in the characterization of coronary atherosclerotic plaques: comparison with intravascular optical coherence tomography
    Tsunenari Soeda
    First Department of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Int J Cardiol 148:313-8. 2011
    ..We studied the diagnostic accuracy of DSCT in the characterization of coronary ASPs, especially lipid-rich ASP with thin fibrous cap (TCFA), in comparison with OCT...
  48. ncbi request reprint Myocardial hypoperfusion detected by cardiac computed tomography in an adult patient with heart failure after classic repair for corrected transposition of the great arteries
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Acta Cardiol 66:535-6. 2011
    ..Cardiac CT is useful for evaluating the distribution of the CA and to predict blood supply to the myocardium in corrected TGA...
  49. doi request reprint Insulin sensitivity and beta-cell function in older Japanese adults without diabetes
    Masao Kanauchi
    Nara Medical University, First Department of Internal Medicine, 840, Shijo cho Kashihara Nara 634 0813, Japan
    Age Ageing 37:330-3. 2008
  50. pmc Azelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial
    Takeshi Takami
    Department of Internal Medicine, Clinic Jingumae, Kashihara, Nara, Japan
    Drug Des Devel Ther 7:175-83. 2013
    ....
  51. ncbi request reprint Elevated levels of fractalkine expression and accumulation of CD16+ monocytes in glomeruli of active lupus nephritis
    Shuhei Yoshimoto
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Am J Kidney Dis 50:47-58. 2007
    ..The relationship of levels of glomerular Fkn expression and infiltration by CD16+ Mos with the severity and diversity of glomerular lesions in human lupus nephritis is not known...
  52. ncbi request reprint ANP is cleared much faster than BNP in patients with congestive heart failure
    Kuniko Kimura
    First Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara, Japan 634 852
    Eur J Clin Pharmacol 63:699-702. 2007
    ..Although both peptides exert their effects by binding to a common receptor (natriuretic peptide receptor A) with about the same affinity, their respective loading and maintenance doses differ...
  53. doi request reprint Primary cardiac lymphoma: echocardiography and F-18-fluorodeoxyglucose positron emission tomography in selection of a biopsy site
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Echocardiography 30:E13-5. 2013
    ..We safely performed biopsy of the lymph nodes and diagnosed the patient with primary cardiac lymphoma. We concluded that echocardiography and FDG-PET are useful for selecting an appropriate biopsy site in primary cardiac lymphoma...
  54. ncbi request reprint Intensive lipid-lowering therapy with rosuvastatin stabilizes lipid-rich coronary plaques. -Evaluation using dual-source computed tomography.-
    Tsunenari Soeda
    First Department of Internal Medicine, Nara Medical University
    Circ J 75:2621-7. 2011
    ..The serial changes of lipid-rich coronary plaques (LRCPs) during rosuvastatin treatment were evaluated non-invasively in patients with acute coronary syndrome (ACS) using dual-source computed tomography (DSCT)...
  55. ncbi request reprint [A case of MPO-ANCA-related microscopic polyangiitis with mixed cryoglobulinemia]
    Osamu Asai
    First Department of Internal Medicine, Nara Medical University, Uda City Hospital, Nara, Japan
    Nihon Jinzo Gakkai Shi 48:377-84. 2006
    ..Therefore, in chronic hepatitis C patients with systemic vasculitis, we should consider the possibility of ANCA-related microscopic polyangiitis and make a correct diagnosis by renal biopsy...
  56. pmc Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    J Cardiovasc Magn Reson 15:87. 2013
    ..We verified whether LV diastolic function could be evaluated by measuring the fractional area change (FAC) using cine cardiovascular magnetic resonance (CMR)...
  57. ncbi request reprint Usefulness of 16-slice multislice spiral computed tomography for follow-up study of coronary stent implantation
    Makoto Watanabe
    First Department of Medicine, Nara Medical University, Kashiara, Japan
    Circ J 70:691-7. 2006
    ..The aim of the present study was to compare the usefulness of MSCT with that of invasive coronary angiography for evaluating coronary stent patency...
  58. pmc The influence of effective energy on computed tomography number depends on tissue characteristics in monoenergetic cardiac imaging
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Radiol Res Pract 2012:150980. 2012
    ....
  59. pmc Rare concurrence of apical hypertrophic cardiomyopathy and effusive constrictive pericarditis
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Open Cardiovasc Med J 5:99-102. 2011
    ..Apical HCM with concurrent effusive constrictive pericarditis was diagnosed. Further studies are required to elucidate the pathophysiology of this condition...
  60. ncbi request reprint Carotid atherosclerosis is associated with brain atrophy in Japanese elders
    Tesseki Kin
    Department of Neurology, Nara Medical University, Kashihara, Japan
    Gerontology 53:1-6. 2007
    ..The relation between atherosclerosis and brain atrophy remains unclear in patients with risk factors for cardiovascular diseases...
  61. ncbi request reprint Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction
    Hajime Iwama
    First Department of Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Am Coll Cardiol 47:1559-67. 2006
    ..Our aim was to investigate cardiac expression of placental growth factor (PlGF) and its clinical significance in patients with acute myocardial infarction (AMI)...
  62. pmc Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis
    Satoshi Somekawa
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Proc Natl Acad Sci U S A 109:12064-9. 2012
    ..These data indicated that TMEM100 may play indispensable roles downstream of BMP9/BMP10-ALK1 signaling during endothelial differentiation and vascular morphogenesis...
  63. ncbi request reprint [NOS gene polymorphism]
    Shigeru Yamano
    First Department of Internal Medicine, Nara Medical University
    Nihon Rinsho 64:459-64. 2006
  64. ncbi request reprint [Therapeutic application of ANP: past and future]
    Yoshihiko Saito
    First Department of Internal Medicine, Nara Medical University
    Nihon Rinsho 62:139-46. 2004
  65. pmc Effects of Azelnidipine plus OlmesaRTAn versus amlodipine plus olmesartan on central blood pressure and left ventricular mass index: the AORTA study
    Takeshi Takami
    Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan
    Vasc Health Risk Manag 7:383-90. 2011
    ..The aim of this study was to compare the effects of olmesartan combined with either azelnidipine or amlodipine on central blood pressure (CBP) and left ventricular mass index (LVMI) in hypertensive patients...
  66. doi request reprint Role of cardiac computed tomography in planning and evaluating percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522 Japan
    J Cardiovasc Comput Tomogr 4:62-5. 2010
    ....
  67. ncbi request reprint Apoptotic myocardial cell death in the setting of arrhythmogenic right ventricular cardiomyopathy
    Kunihiro Yamaji
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Acta Cardiol 60:465-70. 2005
    ..g. CPP-32, Bcl-2, and Bax)...
  68. ncbi request reprint Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells
    Keiichi Imagawa
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Cardiovasc Pharmacol 47:133-8. 2006
    ....
  69. doi request reprint Feasibility of dual gradient-echo in-phase and opposed-phase magnetic resonance imaging for the evaluation of epicardial fat
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Acta Radiol 52:723-9. 2011
    ..Epicardial fat has recently been revealed as having an important role in the development of heart disease, but IPOP-MRI has not been widely applied in this field, probably because of cardiac motion artifacts...
  70. ncbi request reprint Non-invasive quantitation of myocardial fibrosis using combined tissue harmonic imaging and integrated backscatter analysis in dilated cardiomyopathy
    Reiko Mizuno
    Department of General Medicine, Nara Medical University, Kashihara, Japan
    Cardiology 108:11-7. 2007
    ....
  71. ncbi request reprint Pancreatic beta-cell function and insulin sensitivity in japanese subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes mellitus
    Masao Kanauchi
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Metabolism 52:476-81. 2003
    ..In conclusion, both impaired insulin secretion and insulin resistance may contribute to the underlying mechanisms of glucose intolerance in Japanese subjects...
  72. ncbi request reprint Homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index, and oral glucose insulin sensitivity index in nonobese, nondiabetic subjects with high-normal blood pressure
    Masao Kanauchi
    First Department of Internal Medicine, Nara Medical University, Nara 634 0813, Japan
    J Clin Endocrinol Metab 88:3444-6. 2003
    ..These findings indicate that insulin resistance is present even in the high-normal BP categories of nonobese and nondiabetic Japanese individuals...
  73. ncbi request reprint Insulin resistance and pancreatic beta-cell function in patients with hypertensive kidney disease
    Masao Kanauchi
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 0813, Japan
    Nephrol Dial Transplant 19:2025-9. 2004
    ..However, little is known concerning insulin sensitivity among patients with hypertensive kidney disease (HKD), especially in those with moderate or severe renal dysfunction...
  74. pmc Effects of smoking cessation on central blood pressure and arterial stiffness
    Takeshi Takami
    Department of Internal Medicine, Clinic Jingumae, Kashihara, Nara, Japan
    Vasc Health Risk Manag 7:633-8. 2011
    ..Smoking affects arterial stiffness, thus causing an elevation in central blood pressure (CBP). The present study was designed to examine whether smoking cessation treatment improved CBP and arterial stiffness...
  75. doi request reprint The homeobox gene Hex regulates hepatocyte differentiation from embryonic stem cell-derived endoderm
    Atsushi Kubo
    First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Hepatology 51:633-41. 2010
    ....
  76. doi request reprint Non-contrast MRI for the evaluation of hydronephrotic and dysfunctioning kidney secondary to testicular cancer
    Satoshi Okayama
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Ren Fail 31:153-8. 2009
    ..The present case indicates that non-contrast MRI is useful for the evaluation of renal diseases even in elderly patients with renal dysfunction...
  77. ncbi request reprint Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN
    Yoshiharu Nishitani
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Kidney Int 68:1078-85. 2005
    ..In particular, we also prospectively asked if the number of fibroblasts in the renal interstitium correlates with prognosis...
  78. ncbi request reprint Metabolic syndrome and new category 'pre-hypertension' in a Japanese population
    Masao Kanauchi
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Curr Med Res Opin 20:1365-70. 2004
    ..To examine whether insulin resistance and metabolic syndrome are associated with pre-hypertension, a new stage developed by the Joint National Committee on Prevention, Detection, Education and Treatment of High Blood Pressure (JNC-7)...
  79. doi request reprint A case of autoimmune hepatitis exacerbated by the administration of etanercept in the patient with rheumatoid arthritis
    Koji Harada
    First Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara, 634 8522, Japan
    Clin Rheumatol 27:1063-6. 2008
    ..She was diagnosed as autoimmune hepatitis (AIH). Glucocorticoid was started with normalized liver function and stable joint symptoms. AIH was thought to be acutely aggravated by the administration of etanercept...
  80. ncbi request reprint Clinical application of wave intensity for the treatment of essential hypertension
    Shinichi Fujimoto
    Department of General Medicine and Clinical Investigation, Nara Medical University, 840 Shijo, Kashihara, Nara 634 8522, Japan
    Heart Vessels 19:19-22. 2004
    ..Thus, patients with a significant reflection wave may be good candidates for antihypertensive treatment by a vasodilator, such as doxazosin...
  81. ncbi request reprint Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl cyclase-A
    Yuhao Li
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Endocrinology 145:951-8. 2004
    ..Thus, we suggest that androgens contribute to gender-related differences in cardiac hypertrophy and fibrosis by a mechanism involving AT1A receptors and GC-A...
  82. ncbi request reprint White-coat hypertension contributes to the presence of carotid arteriosclerosis
    Takao Nakashima
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Hypertens Res 27:739-45. 2004
    ..Thus, clinical evaluation of white-coat hypertension should be conducted with the potential for target organ damage in mind...
  83. ncbi request reprint [Natriuretic peptides in patients with heart failure]
    Manabu Horii
    First Department of Internal Medicine, Nara Medical University
    Nihon Rinsho 62:84-7. 2004
  84. ncbi request reprint Intravenous leiomyomatosis extending into the right ventricle associated with pulmonary metastasis and extensive arteriovenous fistula
    Junichiro Nishizawa
    Tenri Hospital, Nara Medical University, Nara, Japan
    J Am Coll Surg 198:842-3. 2004
  85. ncbi request reprint Plasma level of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction: a long-term follow-up analysis
    Satoru Suzuki
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circulation 110:1387-91. 2004
    ..We examined whether the plasma BNP level measured 3 to 4 weeks after the onset of AMI represents a reliable prognostic marker for patients with AMI...
  86. ncbi request reprint Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice
    Yuichiro Adachi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 107:2406-8. 2003
    ..Although both angiotensin type 1 (AT1) and type 2 (AT2) receptors are known to be present in the heart, comparatively little is known about the latter. We therefore examined the role played by AT2 receptors in post-AMI heart failure...
  87. ncbi request reprint Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice
    Michio Nakanishi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Hypertension 46:441-7. 2005
    ..These beneficial effects are mediated partly through inhibition of the renin-angiotensin system (RAS), although RAS-independent protective actions of guanylyl cyclase-A are also suggested...
  88. doi request reprint Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese
    Satoru Usami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Hypertens Res 31:89-96. 2008
    ..Our results thus define the (CT)n polymorphism in the 5'-flanking region of the GC-A gene as a potent and novel susceptibility marker for hypertension...
  89. ncbi request reprint Angiotensin II-induced ventricular hypertrophy and extracellular signal-regulated kinase activation are suppressed in mice overexpressing brain natriuretic peptide in circulation
    Nobuki Takahashi
    Department of Medicine and Clinical Science Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hypertens Res 26:847-53. 2003
    ..The mechanism responsible for this inhibition likely involves 1) increased ventricular MKP expression and 2) inhibition of transduction mediators situated upstream of ERK...
  90. ncbi request reprint Aspirin for primary prevention of atherosclerotic disease in Japan
    Takeshi Morimoto
    Center for Medical Education, Kyoto University Graduate School of Medicine, Japan
    J Atheroscler Thromb 14:159-66. 2007
    ..Thus, the JPAD trial should generate reliable data on primary prevention with aspirin for diabetic patients that would also be relevant to other countries...
  91. ncbi request reprint Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure
    Takayoshi Tsutamoto
    Department of Cardiovascular Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520 2192, Japan
    Eur J Heart Fail 9:1032-7. 2007
    ..Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines and is increased in patients with chronic heart failure (CHF)...
  92. ncbi request reprint Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm
    Masafumi Nakayama
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Pharmacogenetics 13:683-8. 2003
    ....
  93. ncbi request reprint Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction
    Rika Kawakami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 110:3306-12. 2004
    ..In the present study, we used BNP-transgenic (BNP-Tg) mice with elevated plasma BNP to determine whether and how BNP contributes to left ventricular remodeling and healing after MI...
  94. ncbi request reprint [Cross-talk between the natriuretic peptide system and the angiotensin system]
    Ichiro Kishimoto
    Kyoto University School of Medicine, Department of Medicine and Clinical Science
    Nihon Rinsho 60:1923-8. 2002
    ..The results suggest that the endogenous natriuretic peptide system inhibits the cardiac angiotensin system and protects the heart from excessive pathological remodelings...
  95. ncbi request reprint Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart
    Yuhao Li
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 106:1722-8. 2002
    ..We investigated whether GC-A interacts with AT1A signaling in the heart by target deletion and pharmacological blockade or stimulation of AT1A in mice...
  96. ncbi request reprint Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials
    Masafumi Kitakaze
    Cardiovascular Division of Medicine, National Cardiovascular Centre, Suita, Osaka, Japan
    Lancet 370:1483-93. 2007
    ..Patients who have acute myocardial infarction remain at major risk of cardiovascular events. We aimed to assess the effects of either human atrial natriuretic peptide or nicorandil on infarct size and cardiovascular outcome...
  97. ncbi request reprint Intracoronary transplantation of non-expanded peripheral blood-derived mononuclear cells promotes improvement of cardiac function in patients with acute myocardial infarction
    Tetsuya Tatsumi
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto University Hospital, Japan
    Circ J 71:1199-207. 2007
    ..This study was designed to examine whether intracoronary transplantation of PBMNCs improves cardiac function after acute myocardial infarction (AMI)...
  98. ncbi request reprint Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium
    Megumi Yamamuro
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Endocrinology 147:1314-21. 2006
    ....
  99. ncbi request reprint Associations of chronic kidney disease with the metabolic syndrome in non-diabetic elderly
    Masao Kanauchi
    Nephrol Dial Transplant 21:3608-9. 2006
  100. ncbi request reprint Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes
    Yasuaki Nakagawa
    Department of Medicine and Clinical Science, Kyoto Graduate School of Medicine, 54 Shogoinkawahara cho, Sakyo ku, Kyoto City, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 41:1010-22. 2006
    ....
  101. ncbi request reprint Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation
    Michio Nakanishi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Circ J 71:1310-6. 2007
    ..In the present study it was examined whether blockade of angiotensin II type 1 receptor (AT1) could improve survival in cases of chronic severe AR...