Takeo Ohnishi

Summary

Affiliation: Nara Medical University
Country: Japan

Publications

  1. ncbi request reprint The disaster at Japan's Fukushima-Daiichi nuclear power plant after the March 11, 2011 earthquake and tsunami, and the resulting spread of radioisotope contamination
    Takeo Ohnishi
    Department of Radiation Oncology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Radiat Res 177:1-14. 2012
  2. pmc Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma
    Yusei Fujita
    Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan
    Radiat Oncol 4:63. 2009
  3. ncbi request reprint Alkylating agent (MNU)-induced mutation in space environment
    T Ohnishi
    Department of Biology, Nara Medical University, Kashihara, Japan
    Adv Space Res 28:563-8. 2001
  4. doi request reprint Detection of space radiation-induced double strand breaks as a track in cell nucleus
    Takeo Ohnishi
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Biochem Biophys Res Commun 390:485-8. 2009
  5. ncbi request reprint Detection of DNA damage induced by space radiation in Mir and space shuttle
    Takeo Ohnishi
    Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    J Radiat Res 43:S133-6. 2002
  6. ncbi request reprint Studies about space radiation promote new fields in radiation biology
    Takeo Ohnishi
    Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    J Radiat Res 43:S7-12. 2002
  7. doi request reprint DNA double-strand breaks: their production, recognition, and repair in eukaryotes
    Takeo Ohnishi
    Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
    Mutat Res 669:8-12. 2009
  8. ncbi request reprint p53 Targeting can enhance cancer therapy via radiation, heat and anti-cancer agents
    Takeo Ohnishi
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Anticancer Agents Med Chem 8:564-70. 2008
  9. ncbi request reprint The role of the p53 molecule in cancer therapies with radiation and/or hyperthermia
    Takeo Ohnishi
    Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara 634 8521 Japan
    J Cancer Res Ther 1:147-50. 2005
  10. ncbi request reprint Biological effects of space radiation
    T Ohnishi
    Department of Biology, Nara Medical University, Nara, Japan
    Biol Sci Space 15:S203-10. 2001

Collaborators

Detail Information

Publications74

  1. ncbi request reprint The disaster at Japan's Fukushima-Daiichi nuclear power plant after the March 11, 2011 earthquake and tsunami, and the resulting spread of radioisotope contamination
    Takeo Ohnishi
    Department of Radiation Oncology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Radiat Res 177:1-14. 2012
    ....
  2. pmc Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma
    Yusei Fujita
    Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan
    Radiat Oncol 4:63. 2009
    ..To clarify the role of p53 gene, the effect of BNCT on oral squamous cell carcinoma (SCC) cells showing either wild- (SAS/neo) or mutant-type (SAS/mp53) p53 was examined...
  3. ncbi request reprint Alkylating agent (MNU)-induced mutation in space environment
    T Ohnishi
    Department of Biology, Nara Medical University, Kashihara, Japan
    Adv Space Res 28:563-8. 2001
    ..We found that there was almost no effect of microgravity on DNA replication and mutation frequency. It is suggested that microgravity might not affect at the stage of substrate incorporation in induced-mutation frequency...
  4. doi request reprint Detection of space radiation-induced double strand breaks as a track in cell nucleus
    Takeo Ohnishi
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Biochem Biophys Res Commun 390:485-8. 2009
    ..From the physical dosimetry with CR-39 plastic nuclear track detectors and thermo-luminescent dosimeters, dose rate was 0.5 mSv per day. These values the exposed dose rate were similar between biological and physical dosimetries...
  5. ncbi request reprint Detection of DNA damage induced by space radiation in Mir and space shuttle
    Takeo Ohnishi
    Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    J Radiat Res 43:S133-6. 2002
    ..These results suggest that DNA damage is caused by space radiation and that it is dependent on the length of the space flight...
  6. ncbi request reprint Studies about space radiation promote new fields in radiation biology
    Takeo Ohnishi
    Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    J Radiat Res 43:S7-12. 2002
    ..For these reasons, we desire to educate space researchers of the next generation based on the consideration of the preservation of the Earth from research about space radiation...
  7. doi request reprint DNA double-strand breaks: their production, recognition, and repair in eukaryotes
    Takeo Ohnishi
    Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
    Mutat Res 669:8-12. 2009
    ..The aim of this review is to provide a basic understanding and overview of how DSBs are produced, recognized and repaired, and to describe the role of some of the genes and proteins involved in DSB repair...
  8. ncbi request reprint p53 Targeting can enhance cancer therapy via radiation, heat and anti-cancer agents
    Takeo Ohnishi
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Anticancer Agents Med Chem 8:564-70. 2008
    ....
  9. ncbi request reprint The role of the p53 molecule in cancer therapies with radiation and/or hyperthermia
    Takeo Ohnishi
    Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara 634 8521 Japan
    J Cancer Res Ther 1:147-50. 2005
    ..In this review, we discuss the p53 activation signaling pathways through the modification of p53 molecules such as phosphorylation after radiation and/or hyperthermia treatments...
  10. ncbi request reprint Biological effects of space radiation
    T Ohnishi
    Department of Biology, Nara Medical University, Nara, Japan
    Biol Sci Space 15:S203-10. 2001
    ..We review here the importance of radiation biology studies on space radiation from the viewpoints of human health and biological evolution, from the beginning of life until today, in the context of environmental genotoxic radiation...
  11. ncbi request reprint Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosis
    Yuichiro Imai
    Department of Oral and Maxillofacial Surgery, Nara Medical University School of Medicine, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Oral Oncol 41:631-6. 2005
    ..These findings suggest that pre-treatment with glycerol may enhance the effectiveness of radiotherapy against oral squamous cell carcinomas bearing an mp53 gene mutation...
  12. ncbi request reprint LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells
    Ken Ohnishi
    Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara 634 8521, Japan
    Int J Oncol 29:249-53. 2006
    ..LY294002 appears to be an attractive candidate for a p53-independent heat sensitizer in hyperthermic cancer therapy...
  13. ncbi request reprint Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status
    Yoko Nagata
    Department of Thoracic and Cardiovascular Surgery, School of Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Int J Oncol 37:1001-10. 2010
    ..Taken together, inhibition of the mTOR signal may be a promising strategy for radiosensitization with no relevance to p53 gene status from the aspects of cell lethality and cell growth depression...
  14. doi request reprint Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation
    Yosuke Nakagawa
    Department of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Biochem Biophys Res Commun 423:654-60. 2012
    ..These results suggest that high-LET radiation enhances apoptosis through the activation of Caspase-3 and Caspase-9, and suppresses cell growth by suppressing Akt-related signaling, even in mp53 bearing cancer cells...
  15. ncbi request reprint siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status
    Ken Ohnishi
    Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Radiat Res 166:454-62. 2006
    ..siRNA targeting appears to be a novel radiation-sensitizing agent, particularly in human TP53 mutant cancer cells...
  16. doi request reprint High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation
    Nobuhiro Yamakawa
    Department of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Cancer Sci 99:1455-60. 2008
    ..These results suggest that high LET radiation enhances apoptosis by activation of Caspase-3 through Caspase-9, even in the presence of mp53...
  17. ncbi request reprint DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
    J Radiat Res 49:645-52. 2008
    ..Antibodies for all these phosphorylated DNA DSB recognition proteins appear to be very effective for the detection and localization of DSB...
  18. pmc DNA ligase IV is a potential molecular target in ACNU sensitivity
    Natsuko Kondo
    Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
    Cancer Sci 101:1881-5. 2010
    ..These findings suggest that the down-regulation of Lig4 might provide a useful tool which can be used to increase cell sensitivity in response to ACNU chemotherapy...
  19. ncbi request reprint ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating
    Akihisa Takahashi
    Departments of Biology, School of Medicine, Nara Medical University, Nara, Japan
    J Radiat Res 51:417-22. 2010
    ..These results indicate that ATM is the predominant protein which is active in the phosphorylation of histone H2AX after heating...
  20. doi request reprint p53-dependent adaptive responses in human cells exposed to space radiations
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
    Int J Radiat Oncol Biol Phys 78:1171-6. 2010
    ..02-0.1 Gy induces a p53-dependent adaptive response in mammalian cells. The aim of the present study was to clarify the effect of space radiations on the adaptive response...
  21. ncbi request reprint Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 gene
    Kazue Yuki
    Department of Otorhinolaryngology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Oncol Rep 11:821-4. 2004
    ..Therefore, glycerol might be useful for chemotherapy in patients with mp53 cancer cells...
  22. ncbi request reprint Evidence for the involvement of double-strand breaks in heat-induced cell killing
    Akihisa Takahashi
    Department of Biology, Nara Medical University School of Medicine, Nara, Japan
    Cancer Res 64:8839-45. 2004
    ..These findings suggest that cell killing might be associated with double-strand break formation via protein denaturation...
  23. doi request reprint siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells
    Noritomo Okamoto
    Department of Otorhinolaryngology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
    Int J Hyperthermia 27:297-304. 2011
    ..These results suggest that heat sensitisation might result from NBS1-siRNA mediated suppression of heat-induced DSB repair, indicating that NBS1-siRNA could potentially function as a heat sensitiser for cancer patients...
  24. doi request reprint Development of thermotolerance requires interaction between polymerase-beta and heat shock proteins
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Cancer Sci 99:973-8. 2008
    ..The present novel findings provide strong evidence that Pol beta functions as a critical element involved in thermotolerance and exerts an important role in heat-induced DSB...
  25. ncbi request reprint High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status
    Akihisa Takahashi
    Department of Biology, Nara Medical University, Nara, Japan
    Int J Radiat Oncol Biol Phys 60:591-7. 2004
    ..We analyzed the death pattern of human lung cancer cells harboring different p53 statuses after irradiation with different levels of linear energy transfer (LET)...
  26. ncbi request reprint Apoptosis-related gene expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53
    Jun ichi Yasumoto
    Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Cancer Lett 204:41-51. 2004
    ..These findings strongly imply that p53 status is a useful candidate for a predictive indicator of the effectiveness in hyperthermic therapy...
  27. doi request reprint The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
    Int J Radiat Biol 86:669-81. 2010
    ..The aim of this study was to clarify the biological effects of space radiations, microgravity, and the space environment on the gene expression of p53-regulated genes...
  28. ncbi request reprint The biological effects of space radiation during long stays in space
    Ken Ohnishi
    Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Biol Sci Space 18:201-5. 2004
    ..In order to understand the exact RBE and any interaction with microgravity, the ISS centrifugation system will be a critical tool, and it is hoped that this system will be in operation as soon as possible...
  29. doi request reprint Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes
    Atsuhisa Kajihara
    Department of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, Nara, Japan
    Int J Hyperthermia 24:605-12. 2008
    ..In this study, attention was focused on p53 as a possible predictive indicator for the efficacy of hyperthermic cancer therapy...
  30. doi request reprint Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage
    Taichi Noda
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Biochem Biophys Res Commun 404:206-10. 2011
    ..These findings suggest that formaldehyde-induced DSBs are repaired by HR through the FA repair pathway which is independent of the FA nuclear core complex...
  31. ncbi request reprint The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
    J Radiat Res 51:91-5. 2010
    ..These results are discussed from perspectives of heat-induced denaturation of proteins and formation of DSBs...
  32. ncbi request reprint Mutation frequency of plasmid DNA and Escherichia coli following long-term space flight on Mir
    Akihisa Takahashi
    Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    J Radiat Res 43:S137-40. 2002
    ..coli strains. It may suggest that space radiation did not influence mutation frequency...
  33. ncbi request reprint High LET heavy ion radiation induces p53-independent apoptosis
    Eiichiro Mori
    Departments of Biology, School of Medicine, Nara Medical University, Nara, Japan
    J Radiat Res 50:37-42. 2009
    ..This review discusses the mechanisms of p53-independent apoptosis by high LET radiation...
  34. pmc Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells
    Ken Ohnishi
    Department of Biology, Nara Medical University, Kashihara, Nara, 634 8521, Japan
    Mol Cancer 1:4. 2002
    ..To examine the effectiveness of glycerol in radiation induced lethality for anaplastic thyroid carcinoma 8305c cells, we performed colony formation assay and apoptosis analysis...
  35. ncbi request reprint Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells
    Ken Ohnishi
    Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Int J Radiat Biol 82:569-75. 2006
    ..We examined the effects of a heat shock protein (hsp) inhibitor, N-formyl-3, 4-methylenedioxy-gamma-butyrolactam (KNK437), on the radiosensitivity of human glioblastoma cells (A-172)...
  36. ncbi request reprint The effect of clinorotation on vestibular compensation in upside-down swimming catfish
    Ken Ohnishi
    Department of Biology, Nara Medical University, Nara, Japan
    Biol Sci Space 17:165-6. 2003
    ..This study suggests that space flight experiments are required to explore whether gravity information is essential for vestibular compensation...
  37. ncbi request reprint [Analysis of death pattern in cancer cells by using different kinds of LET radiation]
    Akihisa Takahashi
    Department of Biology, Nara Medical University
    Nihon Igaku Hoshasen Gakkai Zasshi 62:531-4. 2002
    ..We propose that elucidation of p53-independent apoptosis-related genes might provide new insights into radiotherapy for cancer...
  38. ncbi request reprint Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP
    Ken Ohnishi
    Department of Biology, Nara Medical University School of Medicine, Nara 634 8521, Japan
    Oncol Rep 20:57-61. 2008
    ..These results suggest that XIAP-siRNA is a possible candidate for a radiation sensitizer in cancer radiotherapy, especially in cells with mutated p53...
  39. doi request reprint Heat induces gammaH2AX foci formation in mammalian cells
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Mutat Res 656:88-92. 2008
    ..However, the intensity of gammaH2AX was different in the different cell lines used. These results confirm that heat can induce gammaH2AX foci formation in many mammalian cell lines...
  40. ncbi request reprint Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene
    Junichi Yasumoto
    Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    J Radiat Res 44:41-5. 2003
    ..These results suggest that the X-ray sensitivity of wtp53 cells may come from the expression of these apoptosis-related genes...
  41. ncbi request reprint UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis
    Akihisa Takahashi
    Department of Biology, Nara Medical University School of Medicine, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Photochem Photobiol Sci 5:467-71. 2006
    ..These results suggest that exposing the cells to UV-B prior to exposure to UV-C induced an adaptive response towards DNA damage caused by UV-C exposure, and this UV-C induced damage was repaired through PR activity...
  42. ncbi request reprint The significance of the study about the biological effects of solar ultraviolet radiation using the Exposed Facility on the International Space Station
    Akihisa Takahashi
    Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Biol Sci Space 18:255-60. 2004
    ....
  43. doi request reprint Hdm2 and nitric oxide radicals contribute to the p53-dependent radioadaptive response
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
    Int J Radiat Oncol Biol Phys 71:550-8. 2008
    ..The aim of this work was to characterize the radioadaptive response at the molecular level...
  44. ncbi request reprint Heat-induced phosphorylation of NBS1 in human skin fibroblast cells
    Ken Ohnishi
    Department of Biology, Nara Medical University School of Medicine, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    J Cell Biochem 99:1642-50. 2006
    ..These results suggest that NBS1 is involved in cellular responses to DNA damage which is induced by heat exposure as well as by radiation exposure in human skin fibroblast cells...
  45. ncbi request reprint Time course and spacial distribution of UV effects on human skin in organ culture
    Eiichiro Mori
    Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Radiat Res 49:269-77. 2008
    ..The data obtained in this study using an organ-culture system utilized direct measurements of the biological effects of different wavelengths of UV lights...
  46. pmc DNA ligase IV as a new molecular target for temozolomide
    Natsuko Kondo
    Department of Biology, Nara Medical University, Shijo cho, Kashihara, Japan
    Biochem Biophys Res Commun 387:656-60. 2009
    ..These findings suggest that down regulation of Lig4 might provide a useful tool for cell sensitization during TMZ chemotherapy...
  47. ncbi request reprint Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status
    Isao Asakawa
    Department of Oncoradiology, Nara Medical University, Kashihara, Japan
    Anticancer Res 22:2037-43. 2002
    ....
  48. ncbi request reprint Molecular mechanisms involved in adaptive responses to radiation, UV light, and heat
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
    J Radiat Res 50:385-93. 2009
    ..The following review covers recent research which can help describe or postulate possible mechanisms which may be active in producing adaptive responses to radiation, ultraviolet light, and heat...
  49. ncbi request reprint Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?
    Akihisa Takahashi
    Department of Biology, Nara Medical University School of Medicine, Shijo cho 840, Kashihara, Nara 634 8521, Japan
    Cancer Lett 229:171-9. 2005
    ..In this review, emphasis is on discussing whether gammaH2AX foci formation depends on the formation of DSBs...
  50. pmc Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
    Takeo Ohnishi
    Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    BMC Biotechnol 2:6. 2002
    ....
  51. ncbi request reprint High transmittance of X-rays in the utricular otolith of upside-down swimming catfish, Synodontis nigriventris
    Ken Ohnishi
    Department of Biology, Nara Medical University, Kashihara, Nara, Japan
    Biol Sci Space 16:18-21. 2002
    ..The orientation of the sensory hair cells does not appear to cause the unique postural control...
  52. ncbi request reprint Photoreactivation in Paramecium tetraurelia under conditions of various degrees of ozone layer depletion
    Akihisa Takahashi
    Department of Biology, Nara Medical University School of Medicine, Japan
    Photochem Photobiol 81:1010-4. 2005
    ..5 to 0.5 J/m2 x s. It is suggested that solar-UV radiation would not influence the cell growth of P. tetraurelia for the reason of high PR activity even when the ozone concentration was decreased 30% from the present levels...
  53. ncbi request reprint Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock
    Yoshinori Murao
    Department of Emergency and Critical Care Medicine, Nara Medical University, Kashihara, Nara, Japan 634 8522
    Shock 20:23-8. 2003
    ..HS resuscitation reduced intestinal damage and apoptosis after hemorrhagic shock, suggesting that HS resuscitation may improve the outcome after hemorrhagic shock by reducing apoptosis and damage to the small intestine...
  54. pmc Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final report
    Tsutomu Sugahara
    Japan Health Foundation, Kyoto, Japan
    Int J Hyperthermia 24:123-40. 2008
  55. ncbi request reprint Effects of p53 status and wortmannin treatment on potentially lethal damage repair, with emphasis on the response of intratumor quiescent cells
    Shin Ichiro Masunaga
    Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Sennan gun, Osaka 590 0494, Japan
    Radiat Med 21:120-7. 2003
    ..To examine the effects of p53 status and wortmannin treatment on potentially lethal damage repair, referring to the response of intratumor quiescent cells...
  56. ncbi request reprint Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells
    Shin Ichiro Masunaga
    Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, 2 1010, Asashiro nishi, Kumatori cho, Sennan gun, Osaka 590 0494, Japan
    Oncol Rep 14:393-400. 2005
    ..TX-402 might be more promising than TPZ, although further study of the toxicity to normal tissue is needed...
  57. ncbi request reprint Intercellular signaling mediated by nitric oxide in human glioblastoma cells
    Hideki Matsumoto
    Departments of Experimental Radiology and Health Physics, Fukui Medical University, Matsuoka, Fukui 910 1193, Japan
    Methods Enzymol 359:280-6. 2002
  58. ncbi request reprint Impact of the p53 status of the tumor cells on the effect of reactor neutron beam irradiation, with emphasis on the response of intratumor quiescent cells
    Shin Ichiro Masunaga
    Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Sennan gun, Osaka 590 0494, Japan
    Jpn J Cancer Res 93:1366-77. 2002
    ..The p53 status of the tumor cells had the potential to affect the response to reactor neutron beam irradiation following 10B-carrier administration...
  59. ncbi request reprint Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status
    Shin Ichiro Masunaga
    Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori cho, Sennan gun, Osaka 590 0494
    Cancer Sci 94:125-33. 2003
    ....
  60. ncbi request reprint [Pre-irradiation with a low dose-rate depressed radiation-induced biological effects (2)]
    Akihisa Takahashi
    Dept Biol, Nara Med Univ
    Biol Sci Space 16:195-6. 2002
  61. ncbi request reprint Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants
    Kazuki Harada
    Department of Food Science and Technology, National Fisheries University, Independent Administrative Institution, The Ministry of Agriculture, Forestry and Fisheries of Japan, Shimonoseki shi, Yamaguchi, Japan
    Int J Mol Med 12:741-7. 2003
    ..Therefore, we conclude that proteins synthesized during the interexposure interval, i.e., the products of the uvsD (UV endonuclease beta) and recA (RecA protein) genes contribute to the induction of thermotolerance in D. radiodurans...
  62. ncbi request reprint Indirect influences of radiation on unirradiated cells through irradiated cells
    Hideki Matsumoto
    Dept Exp Radiol Health Phys, Fukui Med Univ
    Biol Sci Space 17:257-8. 2003
    ..At the same time, the accumulation of Hdm2 was observed; suggesting that chronic irradiation with gamma-rays may stimulate the degradation of p53 accumulated by NO-mediated bystander effects...
  63. ncbi request reprint Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations
    Shin Ichiro Masunaga
    Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto, University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 60:570-7. 2004
    ..To determine the effects of mild temperature hyperthermia (MTH) and p53 status of tumor cells on the size of hypoxic fractions (HFs) in solid tumors, with reference to the effect on intratumor quiescent (Q) cell populations...
  64. ncbi request reprint Contribution of radiation-induced, nitric oxide-mediated bystander effect to radiation-induced adaptive response
    Hideki Matsumoto
    Dept Exp Radiol Health Phys, Fac Med Sci, Univ Fukui, Matsuoka, Fukui, Japan
    Biol Sci Space 18:108-9. 2004
    ..This reduction of radiosensitivity of wtp53 cells is just radiation-induced adaptive response, suggesting that NO-mediated bystander effect may considerably contribute to adaptive response induced by radiation...
  65. ncbi request reprint Radiation-induced adaptive responses and bystander effects
    Hideki Matsumoto
    Department of Experimental Radiology and Health Physics, Faculty of Medical Science, University of Fukui, Matsuoka, Fukui, Japan
    Biol Sci Space 18:247-54. 2004
    ..This review focuses on the radiation-induced bystander effect and the adaptive response, provides a description of the two phenomena, and discusses the contribution of the former to the latter...
  66. ncbi request reprint Vanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responses
    Hideki Matsumoto
    Division of Oncology, Biomedical Imaging Research Center, University of Fukui, Eiheiji, Japan
    J Radiat Res 48:97-106. 2007
    ..The present review focuses on the latter two phenomena by summarizing observations supporting their existence, and discussing the linkage between them from the aspect of production of reactive oxygen and nitrogen species...
  67. ncbi request reprint Nitric oxide radicals choreograph a radioadaptive response
    Hideki Matsumoto
    Division of Oncology, Biomedical Imaging Research Center, University of Fukui, Fukui, Japan
    Cancer Res 67:8574-9. 2007
    ..Moreover, radioresistance was observed when cultures were treated with a NO radical-generating agent. These findings suggest that NO radicals are an initiator of the radioadaptive response...
  68. ncbi request reprint Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population
    Shin Ichiro Masunaga
    Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka 590 0494, Japan
    Oncol Rep 18:1589-96. 2007
    ..From the viewpoint of tumor control, including intratumor Q-cell control, wortmannin treatment in combination with gamma-ray irradiation is thought to be useful for suppressing the repair of radiation-induced damage...
  69. ncbi request reprint [Study of biological response by pre-irradiation at a low dose or a low dose-rate]
    Takeo Ohnishi
    Dept Biol, Nara Med Univ
    Biol Sci Space 16:103-4. 2002
  70. ncbi request reprint Human papilloma virus (HPV) DNA associated with prognosis of cervical cancer after radiotherapy
    Yoko Harima
    Department of Radiology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Int J Radiat Oncol Biol Phys 52:1345-51. 2002
    ..Our study explored whether the HPV status of tumors is associated with the outcome of radiotherapy in patients with cervical cancer...
  71. ncbi request reprint Hypergravity modifies the signal transduction of ionizing radiation through p53
    Kumio Okaichi
    Department of Radiation Biophysics, Radiation Effect Research Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    J Radiat Res 43:S261-4. 2002
    ..5 h to 3 h after irradiation, and the inductions of Waf-1 and Bax were suppressed entirely. These results indicate that hypergravity modifies the signal transduction of ionizing radiation through p53 in the cells...
  72. ncbi request reprint Expression of Ku80 in cervical cancer correlates with response to radiotherapy and survival
    Yoko Harima
    Department of Radiology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka, Japan
    Am J Clin Oncol 26:e80-5. 2003
    ..04). The results of this study suggest that a low expression of Ku80 protein leads to radiosensitivity in cervical cancer and that Ku80 might play a role in treatment outcome...
  73. ncbi request reprint [Comparison of surface light scattering of acrylic intraocular lenses made by lathe-cutting and cast-molding methods--long-term observation and experimental study]
    Hitoshi Nishihara
    Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Nihon Ganka Gakkai Zasshi 108:157-61. 2004
    ..To compare the long-term clinical and experimental results of soft acrylic intraocular lenses(IOLs) manufactured by the lathe-cut(LC) method and by the cast-molding(CM) method...
  74. ncbi request reprint [Light scattering observed on the surface of acrylic intraocular lenses ten years after implantation]
    Shigeo Yaguchi
    Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Nihon Ganka Gakkai Zasshi 106:109-11. 2002
    ..To report the long-term status of acrylic intra-ocular lenses...