Research Topics
Genomes and Genes | Takeo OhnishiSummaryAffiliation: Nara Medical University Country: Japan Publications
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Publications
The disaster at Japan's Fukushima-Daiichi nuclear power plant after the March 11, 2011 earthquake and tsunami, and the resulting spread of radioisotope contaminationTakeo Ohnishi
Department of Radiation Oncology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
Radiat Res 177:1-14. 2012....- Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinomaYusei Fujita
Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan
Radiat Oncol 4:63. 2009..To clarify the role of p53 gene, the effect of BNCT on oral squamous cell carcinoma (SCC) cells showing either wild- (SAS/neo) or mutant-type (SAS/mp53) p53 was examined... - Alkylating agent (MNU)-induced mutation in space environmentT Ohnishi
Department of Biology, Nara Medical University, Kashihara, Japan
Adv Space Res 28:563-8. 2001..We found that there was almost no effect of microgravity on DNA replication and mutation frequency. It is suggested that microgravity might not affect at the stage of substrate incorporation in induced-mutation frequency... - Detection of space radiation-induced double strand breaks as a track in cell nucleusTakeo Ohnishi
Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
Biochem Biophys Res Commun 390:485-8. 2009..From the physical dosimetry with CR-39 plastic nuclear track detectors and thermo-luminescent dosimeters, dose rate was 0.5 mSv per day. These values the exposed dose rate were similar between biological and physical dosimetries... - Detection of DNA damage induced by space radiation in Mir and space shuttleTakeo Ohnishi
Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
J Radiat Res (Tokyo) 43:S133-6. 2002..These results suggest that DNA damage is caused by space radiation and that it is dependent on the length of the space flight... - Studies about space radiation promote new fields in radiation biologyTakeo Ohnishi
Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
J Radiat Res (Tokyo) 43:S7-12. 2002..For these reasons, we desire to educate space researchers of the next generation based on the consideration of the preservation of the Earth from research about space radiation... - DNA double-strand breaks: their production, recognition, and repair in eukaryotesTakeo Ohnishi
Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
Mutat Res 669:8-12. 2009..The aim of this review is to provide a basic understanding and overview of how DSBs are produced, recognized and repaired, and to describe the role of some of the genes and proteins involved in DSB repair... - p53 Targeting can enhance cancer therapy via radiation, heat and anti-cancer agentsTakeo Ohnishi
Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
Anticancer Agents Med Chem 8:564-70. 2008.... - The role of the p53 molecule in cancer therapies with radiation and/or hyperthermiaTakeo Ohnishi
Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara 634 8521 Japan
J Cancer Res Ther 1:147-50. 2005..In this review, we discuss the p53 activation signaling pathways through the modification of p53 molecules such as phosphorylation after radiation and/or hyperthermia treatments... - Biological effects of space radiationT Ohnishi
Department of Biology, Nara Medical University, Nara, Japan
Biol Sci Space 15:S203-10. 2001..We review here the importance of radiation biology studies on space radiation from the viewpoints of human health and biological evolution, from the beginning of life until today, in the context of environmental genotoxic radiation... - Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosisYuichiro Imai
Department of Oral and Maxillofacial Surgery, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan
Oral Oncol 41:631-6. 2005..These findings suggest that pre-treatment with glycerol may enhance the effectiveness of radiotherapy against oral squamous cell carcinomas bearing an mp53 gene mutation... - LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cellsKen Ohnishi
Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara 634-8521, Japan
Int J Oncol 29:249-53. 2006..LY294002 appears to be an attractive candidate for a p53-independent heat sensitizer in hyperthermic cancer therapy... - Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene statusYoko Nagata
Department of Thoracic and Cardiovascular Surgery, School of Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
Int J Oncol 37:1001-10. 2010..Taken together, inhibition of the mTOR signal may be a promising strategy for radiosensitization with no relevance to p53 gene status from the aspects of cell lethality and cell growth depression... - Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiationYosuke Nakagawa
Department of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
Biochem Biophys Res Commun 423:654-60. 2012..These results suggest that high-LET radiation enhances apoptosis through the activation of Caspase-3 and Caspase-9, and suppresses cell growth by suppressing Akt-related signaling, even in mp53 bearing cancer cells... - siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 statusKen Ohnishi
Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
Radiat Res 166:454-62. 2006..siRNA targeting appears to be a novel radiation-sensitizing agent, particularly in human TP53 mutant cancer cells... - High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activationNobuhiro Yamakawa
Department of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
Cancer Sci 99:1455-60. 2008..These results suggest that high LET radiation enhances apoptosis by activation of Caspase-3 through Caspase-9, even in the presence of mp53... - DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleusAkihisa Takahashi
Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
J Radiat Res (Tokyo) 49:645-52. 2008..Antibodies for all these phosphorylated DNA DSB recognition proteins appear to be very effective for the detection and localization of DSB... - DNA ligase IV is a potential molecular target in ACNU sensitivityNatsuko Kondo
Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
Cancer Sci 101:1881-5. 2010..These findings suggest that the down-regulation of Lig4 might provide a useful tool which can be used to increase cell sensitivity in response to ACNU chemotherapy... - ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heatingAkihisa Takahashi
Departments of Biology, School of Medicine, Nara Medical University, Nara, Japan
J Radiat Res (Tokyo) 51:417-22. 2010..These results indicate that ATM is the predominant protein which is active in the phosphorylation of histone H2AX after heating... - p53-dependent adaptive responses in human cells exposed to space radiationsAkihisa Takahashi
Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
Int J Radiat Oncol Biol Phys 78:1171-6. 2010..02-0.1 Gy induces a p53-dependent adaptive response in mammalian cells. The aim of the present study was to clarify the effect of space radiations on the adaptive response... - Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 geneKazue Yuki
Department of Otorhinolaryngology, Nara Medical University, Kashihara, Nara 634-8521, Japan
Oncol Rep 11:821-4. 2004..Therefore, glycerol might be useful for chemotherapy in patients with mp53 cancer cells... - Evidence for the involvement of double-strand breaks in heat-induced cell killingAkihisa Takahashi
Department of Biology, Nara Medical University School of Medicine, Nara, Japan
Cancer Res 64:8839-45. 2004..These findings suggest that cell killing might be associated with double-strand break formation via protein denaturation... - siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cellsNoritomo Okamoto
Department of Otorhinolaryngology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
Int J Hyperthermia 27:297-304. 2011..These results suggest that heat sensitisation might result from NBS1-siRNA mediated suppression of heat-induced DSB repair, indicating that NBS1-siRNA could potentially function as a heat sensitiser for cancer patients... - Development of thermotolerance requires interaction between polymerase-beta and heat shock proteinsAkihisa Takahashi
Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
Cancer Sci 99:973-8. 2008..The present novel findings provide strong evidence that Pol beta functions as a critical element involved in thermotolerance and exerts an important role in heat-induced DSB... - High-LET radiation enhanced apoptosis but not necrosis regardless of p53 statusAkihisa Takahashi
Department of Biology, Nara Medical University, Nara, Japan
Int J Radiat Oncol Biol Phys 60:591-7. 2004..We proposed that the elucidation of the p53-independent apoptosis-related genes might provide new insights into radiotherapy for cancer... - Apoptosis-related gene expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53Jun-Ichi Yasumoto
Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
Cancer Lett 204:41-51. 2004..These findings strongly imply that p53 status is a useful candidate for a predictive indicator of the effectiveness in hyperthermic therapy... - The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflightAkihisa Takahashi
Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
Int J Radiat Biol 86:669-81. 2010..The aim of this study was to clarify the biological effects of space radiations, microgravity, and the space environment on the gene expression of p53-regulated genes... - The biological effects of space radiation during long stays in spaceKen Ohnishi
Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
Biol Sci Space 18:201-5. 2004..In order to understand the exact RBE and any interaction with microgravity, the ISS centrifugation system will be a critical tool, and it is hoped that this system will be in operation as soon as possible... - Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypesAtsuhisa Kajihara
Department of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, Nara, Japan
Int J Hyperthermia 24:605-12. 2008..In this study, attention was focused on p53 as a possible predictive indicator for the efficacy of hyperthermic cancer therapy... - Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damageTaichi Noda
Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
Biochem Biophys Res Commun 404:206-10. 2011..These findings suggest that formaldehyde-induced DSBs are repaired by HR through the FA repair pathway which is independent of the FA nuclear core complex... - The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatmentAkihisa Takahashi
Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
J Radiat Res (Tokyo) 51:91-5. 2010..These results are discussed from perspectives of heat-induced denaturation of proteins and formation of DSBs... - Mutation frequency of plasmid DNA and Escherichia coli following long-term space flight on MirAkihisa Takahashi
Department of Biology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan
J Radiat Res (Tokyo) 43:S137-40. 2002..coli strains. It may suggest that space radiation did not influence mutation frequency... - High LET heavy ion radiation induces p53-independent apoptosisEiichiro Mori
Departments of Biology, School of Medicine, Nara Medical University, Nara, Japan
J Radiat Res (Tokyo) 50:37-42. 2009..This review discusses the mechanisms of p53-independent apoptosis by high LET radiation... - Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cellsKen Ohnishi
Department of Biology, Nara Medical University, Kashihara, Nara, 634 8521, Japan
Mol Cancer 1:4. 2002..To examine the effectiveness of glycerol in radiation induced lethality for anaplastic thyroid carcinoma 8305c cells, we performed colony formation assay and apoptosis analysis... - Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cellsKen Ohnishi
Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
Int J Radiat Biol 82:569-75. 2006..CONCLUSIONS: These results show that KNK437 causes cells to be resistant to radiation, and that this might be correlated with maintenance of G2 arrest in the cell cycle regulation... - The effect of clinorotation on vestibular compensation in upside-down swimming catfishKen Ohnishi
Department of Biology, Nara Medical University, Nara, Japan
Biol Sci Space 17:165-6. 2003..This study suggests that space flight experiments are required to explore whether gravity information is essential for vestibular compensation... - [Analysis of death pattern in cancer cells by using different kinds of LET radiation]Akihisa Takahashi
Department of Biology, Nara Medical University
Nihon Igaku Hoshasen Gakkai Zasshi 62:531-4. 2002..We propose that elucidation of p53-independent apoptosis-related genes might provide new insights into radiotherapy for cancer... - Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAPKen Ohnishi
Department of Biology, Nara Medical University School of Medicine, Nara 634 8521, Japan
Oncol Rep 20:57-61. 2008..These results suggest that XIAP-siRNA is a possible candidate for a radiation sensitizer in cancer radiotherapy, especially in cells with mutated p53... - Heat induces gammaH2AX foci formation in mammalian cellsAkihisa Takahashi
Department of Biology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
Mutat Res 656:88-92. 2008..However, the intensity of gammaH2AX was different in the different cell lines used. These results confirm that heat can induce gammaH2AX foci formation in many mammalian cell lines... - Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 geneJunichi Yasumoto
Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
J Radiat Res (Tokyo) 44:41-5. 2003..These results suggest that the X-ray sensitivity of wtp53 cells may come from the expression of these apoptosis-related genes... - UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilisAkihisa Takahashi
Department of Biology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
Photochem Photobiol Sci 5:467-71. 2006..These results suggest that exposing the cells to UV-B prior to exposure to UV-C induced an adaptive response towards DNA damage caused by UV-C exposure, and this UV-C induced damage was repaired through PR activity... - The significance of the study about the biological effects of solar ultraviolet radiation using the Exposed Facility on the International Space StationAkihisa Takahashi
Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
Biol Sci Space 18:255-60. 2004.... - Hdm2 and nitric oxide radicals contribute to the p53-dependent radioadaptive responseAkihisa Takahashi
Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
Int J Radiat Oncol Biol Phys 71:550-8. 2008..The aim of this work was to characterize the radioadaptive response at the molecular level... - Heat-induced phosphorylation of NBS1 in human skin fibroblast cellsKen Ohnishi
Department of Biology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
J Cell Biochem 99:1642-50. 2006..These results suggest that NBS1 is involved in cellular responses to DNA damage which is induced by heat exposure as well as by radiation exposure in human skin fibroblast cells... - Time course and spacial distribution of UV effects on human skin in organ cultureEiichiro Mori
Department of Biology, School of Medicine, Nara Medical University, Kashihara, Nara, Japan
J Radiat Res 49:269-77. 2008..The data obtained in this study using an organ-culture system utilized direct measurements of the biological effects of different wavelengths of UV lights... - DNA ligase IV as a new molecular target for temozolomideNatsuko Kondo
Department of Biology, Nara Medical University, Shijo cho, Kashihara, Japan
Biochem Biophys Res Commun 387:656-60. 2009..These findings suggest that down regulation of Lig4 might provide a useful tool for cell sensitization during TMZ chemotherapy... - Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene statusIsao Asakawa
Department of Oncoradiology, Nara Medical University, Kashihara, Japan
Anticancer Res 22:2037-43. 2002..C-beams are proposed as being useful for cancer radiation therapy regardless of p53 gene status... - Molecular mechanisms involved in adaptive responses to radiation, UV light, and heatAkihisa Takahashi
Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
J Radiat Res (Tokyo) 50:385-93. 2009..The following review covers recent research which can help describe or postulate possible mechanisms which may be active in producing adaptive responses to radiation, ultraviolet light, and heat... - Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?Akihisa Takahashi
Department of Biology, Nara Medical University School of Medicine, Shijo cho 840, Kashihara, Nara 634 8521, Japan
Cancer Lett 229:171-9. 2005..In this review, emphasis is on discussing whether gammaH2AX foci formation depends on the formation of DSBs... - Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53Takeo Ohnishi
Department of Biology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
BMC Biotechnol 2:6. 2002.... - High transmittance of X-rays in the utricular otolith of upside-down swimming catfish, Synodontis nigriventrisKen Ohnishi
Department of Biology, Nara Medical University, Kashihara, Nara, Japan
Biol Sci Space 16:18-21. 2002..The orientation of the sensory hair cells does not appear to cause the unique postural control... - Photoreactivation in Paramecium tetraurelia under conditions of various degrees of ozone layer depletionAkihisa Takahashi
Department of Biology, Nara Medical University School of Medicine, Japan
Photochem Photobiol 81:1010-4. 2005..5 to 0.5 J/m2 x s. It is suggested that solar-UV radiation would not influence the cell growth of P. tetraurelia for the reason of high PR activity even when the ozone concentration was decreased 30% from the present levels... - Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shockYoshinori Murao
Department of Emergency and Critical Care Medicine, Nara Medical University, Kashihara, Nara, Japan 634 8522
Shock 20:23-8. 2003..HS resuscitation reduced intestinal damage and apoptosis after hemorrhagic shock, suggesting that HS resuscitation may improve the outcome after hemorrhagic shock by reducing apoptosis and damage to the small intestine... - Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final reportTsutomu Sugahara
Japan Health Foundation, Kyoto, Japan
Int J Hyperthermia 24:123-40. 2008 - Effects of p53 status and wortmannin treatment on potentially lethal damage repair, with emphasis on the response of intratumor quiescent cellsShin-ichiro Masunaga
Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Sennan-gun, Osaka 590-0494, Japan
Radiat Med 21:120-7. 2003..CONCLUSION: PLDR in vivo was thought to be a p53-dependent event whether in total or Q tumor cell populations... - Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cellsShin Ichiro Masunaga
Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, 2 1010, Asashiro nishi, Kumatori cho, Sennan gun, Osaka 590 0494, Japan
Oncol Rep 14:393-400. 2005..TX-402 might be more promising than TPZ, although further study of the toxicity to normal tissue is needed... - Intercellular signaling mediated by nitric oxide in human glioblastoma cellsHideki Matsumoto
Departments of Experimental Radiology and Health Physics, Fukui Medical University, Matsuoka, Fukui 910-1193, Japan
Methods Enzymol 359:280-6. 2002 - Impact of the p53 status of the tumor cells on the effect of reactor neutron beam irradiation, with emphasis on the response of intratumor quiescent cellsShin Ichiro Masunaga
Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Sennan gun, Osaka 590 0494, Japan
Jpn J Cancer Res 93:1366-77. 2002..The p53 status of the tumor cells had the potential to affect the response to reactor neutron beam irradiation following 10B-carrier administration... - Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 statusShin Ichiro Masunaga
Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori cho, Sennan gun, Osaka 590 0494
Cancer Sci 94:125-33. 2003.... - [Pre-irradiation with a low dose-rate depressed radiation-induced biological effects (2)]Akihisa Takahashi
Dept. Biol, Nara Med. Univ
Biol Sci Space 16:195-6. 2002 - Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutantsKazuki Harada
Department of Food Science and Technology, National Fisheries University, Independent Administrative Institution, The Ministry of Agriculture, Forestry and Fisheries of Japan, Shimonoseki shi, Yamaguchi, Japan
Int J Mol Med 12:741-7. 2003..Therefore, we conclude that proteins synthesized during the interexposure interval, i.e., the products of the uvsD (UV endonuclease beta) and recA (RecA protein) genes contribute to the induction of thermotolerance in D. radiodurans... - Indirect influences of radiation on unirradiated cells through irradiated cellsHideki Matsumoto
Dept. Exp. Radiol. Health Phys, Fukui Med. Univ
Biol Sci Space 17:257-8. 2003..At the same time, the accumulation of Hdm2 was observed; suggesting that chronic irradiation with gamma-rays may stimulate the degradation of p53 accumulated by NO-mediated bystander effects... - Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populationsShin Ichiro Masunaga
Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto, University, Osaka, Japan
Int J Radiat Oncol Biol Phys 60:570-7. 2004..To determine the effects of mild temperature hyperthermia (MTH) and p53 status of tumor cells on the size of hypoxic fractions (HFs) in solid tumors, with reference to the effect on intratumor quiescent (Q) cell populations... - Contribution of radiation-induced, nitric oxide-mediated bystander effect to radiation-induced adaptive responseHideki Matsumoto
Dept. Exp. Radiol. Health Phys, Fac. Med. Sci, Univ. Fukui, Matsuoka, Fukui, Japan
Biol Sci Space 18:108-9. 2004..This reduction of radiosensitivity of wtp53 cells is just radiation-induced adaptive response, suggesting that NO-mediated bystander effect may considerably contribute to adaptive response induced by radiation... - Radiation-induced adaptive responses and bystander effectsHideki Matsumoto
Department of Experimental Radiology and Health Physics, Faculty of Medical Science, University of Fukui, Matsuoka, Fukui, Japan
Biol Sci Space 18:247-54. 2004..This review focuses on the radiation-induced bystander effect and the adaptive response, provides a description of the two phenomena, and discusses the contribution of the former to the latter... - Vanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responsesHideki Matsumoto
Division of Oncology, Biomedical Imaging Research Center, University of Fukui, Eiheiji, Japan
J Radiat Res (Tokyo) 48:97-106. 2007..The present review focuses on the latter two phenomena by summarizing observations supporting their existence, and discussing the linkage between them from the aspect of production of reactive oxygen and nitrogen species... - Nitric oxide radicals choreograph a radioadaptive responseHideki Matsumoto
Division of Oncology, Biomedical Imaging Research Center, University of Fukui, Fukui, Japan
Cancer Res 67:8574-9. 2007..Moreover, radioresistance was observed when cultures were treated with a NO radical-generating agent. These findings suggest that NO radicals are an initiator of the radioadaptive response... - Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell populationShin Ichiro Masunaga
Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka 590 0494, Japan
Oncol Rep 18:1589-96. 2007..From the viewpoint of tumor control, including intratumor Q-cell control, wortmannin treatment in combination with gamma-ray irradiation is thought to be useful for suppressing the repair of radiation-induced damage... - [Study of biological response by pre-irradiation at a low dose or a low dose-rate]Takeo Ohnishi
Dept. Biol, Nara Med. Univ
Biol Sci Space 16:103-4. 2002 - Human papilloma virus (HPV) DNA associated with prognosis of cervical cancer after radiotherapyYoko Harima
Department of Radiology, Kansai Medical University, Moriguchi City, Osaka, Japan
Int J Radiat Oncol Biol Phys 52:1345-51. 2002..Our study explored whether the HPV status of tumors is associated with the outcome of radiotherapy in patients with cervical cancer... - Hypergravity modifies the signal transduction of ionizing radiation through p53Kumio Okaichi
Department of Radiation Biophysics, Radiation Effect Research Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
J Radiat Res (Tokyo) 43:S261-4. 2002..5 h to 3 h after irradiation, and the inductions of Waf-1 and Bax were suppressed entirely. These results indicate that hypergravity modifies the signal transduction of ionizing radiation through p53 in the cells... - Expression of Ku80 in cervical cancer correlates with response to radiotherapy and survivalYoko Harima
Department of Radiology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka, Japan
Am J Clin Oncol 26:e80-5. 2003..04). The results of this study suggest that a low expression of Ku80 protein leads to radiosensitivity in cervical cancer and that Ku80 might play a role in treatment outcome... - [Comparison of surface light scattering of acrylic intraocular lenses made by lathe-cutting and cast-molding methods--long-term observation and experimental study]Hitoshi Nishihara
Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan
Nippon Ganka Gakkai Zasshi 108:157-61. 2004..4 +/- 5.4 CCT in the CM group. Mean surface roughness was 0.70 +/- 0.07 nm in the LC group and 6.16 +/- 0.97 nm in the CM group. CONCLUSION: Acrylic IOLs manufactured by the LC method are more stable in long-termuse... - [Light scattering observed on the surface of acrylic intraocular lenses ten years after implantation]Shigeo Yaguchi
Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan
Nippon Ganka Gakkai Zasshi 106:109-11. 2002..CONCLUSION: Surface scattering from acrylic intra-ocular lenses is a new finding in long-term observations. A possible etiology may be structural changes of the internal polymer...