Kenji Kohno

Summary

Affiliation: Nara Institute of Science and Technology
Country: Japan

Publications

  1. pmc An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1
    Daisuke Oikawa
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Biochem J 391:135-42. 2005
  2. pmc Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
    Yukio Kimata
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    J Cell Biol 179:75-86. 2007
  3. ncbi request reprint RNase domains determine the functional difference between IRE1alpha and IRE1beta
    Yusuke Imagawa
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
    FEBS Lett 582:656-60. 2008
  4. pmc Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro
    Sayoko Shinya
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Nucleic Acids Res 39:5245-54. 2011
  5. ncbi request reprint How transmembrane proteins sense endoplasmic reticulum stress
    Kenji Kohno
    Department of Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara, Japan
    Antioxid Redox Signal 9:2295-303. 2007
  6. ncbi request reprint Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals
    Kenji Kohno
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192 Japan
    J Biochem 147:27-33. 2010
  7. ncbi request reprint A diphtheria toxin receptor deficient in epidermal growth factor-like biological activity
    Norihisa Furukawa
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0192
    J Biochem 140:831-41. 2006
  8. pmc Saccharomyces cerevisiae Rot1 is an essential molecular chaperone in the endoplasmic reticulum
    Masato Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Mol Biol Cell 19:3514-25. 2008
  9. ncbi request reprint A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins
    Pattarawut Sopha
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan
    Cell Struct Funct 37:177-87. 2012
  10. doi request reprint Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA
    Kota Yanagitani
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan
    Mol Cell 34:191-200. 2009

Collaborators

Detail Information

Publications46

  1. pmc An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1
    Daisuke Oikawa
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Biochem J 391:135-42. 2005
    ..Furthermore, recombinant fragments of subregion IV exhibited a self-binding ability. Therefore, although its sequence is little conserved evolutionarily, subregion IV plays an essential role to promote Ire1 dimer formation...
  2. pmc Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
    Yukio Kimata
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    J Cell Biol 179:75-86. 2007
    ..In the first step, BiP dissociation from Ire1 leads to its cluster formation. In the second step, direct interaction of unfolded proteins with the CSSR orients the cytosolic effector domains of clustered Ire1 molecules...
  3. ncbi request reprint RNase domains determine the functional difference between IRE1alpha and IRE1beta
    Yusuke Imagawa
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
    FEBS Lett 582:656-60. 2008
    ..Here, we show by both in vivo and in vitro analyses that the RNase domain of IRE1 determines the functional specificities of each of these isoforms...
  4. pmc Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro
    Sayoko Shinya
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Nucleic Acids Res 39:5245-54. 2011
    ..These studies reveal the utility of the assay system and the unique properties of the mammalian cytosolic enzyme that can promote the splicing of XBP1u mRNA...
  5. ncbi request reprint How transmembrane proteins sense endoplasmic reticulum stress
    Kenji Kohno
    Department of Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara, Japan
    Antioxid Redox Signal 9:2295-303. 2007
    ..This review focuses on current progress with efforts to elucidate how stress sensors recognize the accumulation of unfolded proteins...
  6. ncbi request reprint Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals
    Kenji Kohno
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192 Japan
    J Biochem 147:27-33. 2010
    ..Higher eukaryotes have evolved two other sensors, PERK and ATF6. This review focuses on the current progress in our understanding of stress-sensing mechanisms, in particular, the similarities and differences between yeast and mammals...
  7. ncbi request reprint A diphtheria toxin receptor deficient in epidermal growth factor-like biological activity
    Norihisa Furukawa
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0192
    J Biochem 140:831-41. 2006
    ..These novel DT receptors should be useful for the generation of transgenic mice by TRECK...
  8. pmc Saccharomyces cerevisiae Rot1 is an essential molecular chaperone in the endoplasmic reticulum
    Masato Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Mol Biol Cell 19:3514-25. 2008
    ..In addition, their dependency on Rot1 appeared different. We therefore propose that Rot1 is a general chaperone with some substrate specificity...
  9. ncbi request reprint A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins
    Pattarawut Sopha
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan
    Cell Struct Funct 37:177-87. 2012
    ..Compared with DNAJB12 mRNA that was widely expressed in mouse tissues, DNAJB14 mRNA was expressed more weakly, being most abundant in testis, implying its specific role in this tissue...
  10. doi request reprint Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA
    Kota Yanagitani
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan
    Mol Cell 34:191-200. 2009
    ..This system serves to enhance cytoplasmic splicing and could facilitate a more rapid response to ER stress, and represents a unique way of cotranslational protein targeting coupled to mRNA maturation...
  11. pmc Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
    Thanyarat Promlek
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Mol Biol Cell 22:3520-32. 2011
    ..We therefore conclude that the cytosolic (or transmembrane) domain of Ire1 senses membrane aberrancy, while, as proposed previously, unfolded proteins accumulating in the ER interact with and activate Ire1...
  12. ncbi request reprint Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1
    Daisuke Oikawa
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    J Cell Sci 120:1681-8. 2007
    ..These observations indicate that in addition to BiP dissociation and self-association of Ire1, another unknown change on the luminal side is crucial for Ire1 activation...
  13. doi request reprint Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA
    Kota Yanagitani
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0192, Japan
    Science 331:586-9. 2011
    ..Thus, translational pausing may be used for unexpectedly diverse cellular processes in mammalian cells...
  14. doi request reprint BiP-bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response
    Yuki Ishiwata-Kimata
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Genes Cells 18:288-301. 2013
    ..We thus propose that upon persistent ER stress, Ire1 is weakly and continuously activated in a nonclustered form through its (re)association with BiP, which disperses the Ire1 clusters...
  15. doi request reprint Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins
    Daisuke Nakamura
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    FEBS Lett 585:133-8. 2011
    ....
  16. ncbi request reprint Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins
    Yukio Kimata
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Genes Cells 11:59-69. 2006
    ..Moreover, we categorized 15 genes as those down-regulated by the UPR, most of which seem to encode cell surface or extracellular proteins. This UPR-mediated gene repression may alleviate the load of client proteins targeted to the ER...
  17. ncbi request reprint F-actin and a type-II myosin are required for efficient clustering of the ER stress sensor Ire1
    Yuki Ishiwata-Kimata
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan
    Cell Struct Funct 38:135-43. 2013
    ..Finally, we demonstrated that Ire1 clusters are predominantly located on or near actin filaments. Therefore, we propose that actin filaments play an important role in ER stress-induced clustering of Ire1. ..
  18. pmc A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
    Yukio Kimata
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    J Cell Biol 167:445-56. 2004
    ..We conclude that in the ER stress-sensory system BiP is not the principal determinant of Ire1 activity, but an adjustor for sensitivity to various stresses...
  19. ncbi request reprint Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding
    Masato Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0192
    J Biochem 139:597-605. 2006
    ..This implies that the protein folding machinery in which Rot1p is involved chaperones proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies...
  20. ncbi request reprint Zinc depletion activates the endoplasmic reticulum-stress sensor Ire1 via pleiotropic mechanisms
    Thanh Sy Le Nguyen
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan
    Biosci Biotechnol Biochem 77:1337-9. 2013
    ..ER-stressing stimuli activating Ire1 are known to include ER accumulation of unfolded proteins and membrane-lipid aberrancy. According to the findings presented here, zinc deficiency causes both types of abnormality...
  21. ncbi request reprint A genetic link between the unfolded protein response and vesicle formation from the endoplasmic reticulum
    Hironori Higashio
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology NAIST, Takayama, Ikoma, Nara 630 0101, Japan
    Biochem Biophys Res Commun 296:568-74. 2002
    ..These findings suggest that the activation of the UPR affects ER-to-Golgi transport via stimulation of COPII vesicle formation from the ER...
  22. doi request reprint Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue
    Hiroshi Kadokura
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Aoba ku, Sendai, Miyagi 980 8577, Japan Electronic address
    Biochem Biophys Res Commun 440:245-50. 2013
    ..Thus, this approach enabled us to detect and identify redox partners of a PDI family member from an animal tissue...
  23. pmc Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins
    Yukio Kimata
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Japan
    Mol Biol Cell 14:2559-69. 2003
    ..We speculate that recognition of unfolded proteins is based on their competition with Ire1 for binding with BiP/Kar2...
  24. ncbi request reprint 3'-UTR-dependent regulation of mRNA turnover is critical for differential distribution patterns of cyclic gene mRNAs
    Yasuhide Nitanda
    Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan
    FEBS J 281:146-56. 2014
    ..Our findings suggest that 3'-UTR-dependent regulation of mRNA turnover plays a crucial role in the diverse patterns of mRNA distribution during development. ..
  25. pmc Negative feedback by IRE1β optimizes mucin production in goblet cells
    Akio Tsuru
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Proc Natl Acad Sci U S A 110:2864-9. 2013
    ..These findings suggest that in goblet cells, IRE1β, but not IRE1α, promotes efficient protein folding and secretion in the ER by optimizing the level of mRNA encoding their major secretory product, MUC2...
  26. pmc The period of the somite segmentation clock is sensitive to Notch activity
    Woong Kim
    Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Mol Biol Cell 22:3541-9. 2011
    ..Therefore we propose that the period of the somite segmentation clock is sensitive to Notch activity and that Nrarp plays essential roles in the morphology of vertebrae and ribs...
  27. ncbi request reprint Causal links between protein folding in the ER and events along the secretory pathway
    Masato Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Autophagy 2:323-4. 2006
    ..Mutation of the ROT1 gene caused defects in cell wall synthesis and lysis of autophagic bodies. We suggest that Rot1 is required for folding of proteins engaged in these cellular processes...
  28. ncbi request reprint Impairment of the DNA binding activity of the TATA-binding protein renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth
    Hidezumi Ohdate
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    J Biol Chem 278:14647-56. 2003
    ..We found that the transcription of some genes depends on functions possessed by both Tih2p and TBP and that these functions are substantially impaired in the spt15/tih2-ts160 double mutants that confer synthetic growth defects...
  29. ncbi request reprint A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR
    Yo Hei Yamamoto
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Cell Struct Funct 35:107-16. 2010
    ..Conversely, knockdown of DNAJB12 expression attenuated the degradation of CFTR. Thus, DNAJB12 is a novel mammalian ER-localized J-protein that plays a vital role in the quality control of membrane proteins...
  30. ncbi request reprint Transgenic mice expressing a fully nontoxic diphtheria toxin mutant, not CRM197 mutant, acquire immune tolerance against diphtheria toxin
    Yasuko Kimura
    Laboratory of Molecular and Cell Genetics, Division of Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    J Biochem 142:105-12. 2007
    ..On the other hand, the K51E/E148K DT mutant exhibited no detectable cytotoxicity. This led us to successfully obtain DT gene transgenic mice, which exhibited no histological abnormalities, and indeed acquired immune tolerance to DT...
  31. ncbi request reprint JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs
    Akira Hosoda
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Japan
    J Biol Chem 278:2669-76. 2003
    ..We speculate that for the folding of some proteins in the ER, chaperoning by BiP and formation of proper disulfide bonds may synchronously occur in a JPDI-dependent manner...
  32. ncbi request reprint Regulation of human STARD4 gene expression under endoplasmic reticulum stress
    Seiko Yamada
    Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Biochem Biophys Res Commun 343:1079-85. 2006
    ..This study is a first step in elucidating the relationship between lipid metabolism and the ER stress response...
  33. doi request reprint Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
    Yukio Kimata
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Curr Opin Cell Biol 23:135-42. 2011
    ..These properties may account for the different responses observed under different conditions in mammalian cells, which carry multiple ER-stress sensors...
  34. pmc Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM
    Shinichi Hayashi
    Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
    PLoS ONE 4:e5603. 2009
    ....
  35. ncbi request reprint Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair
    Yoko Fujioka
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    J Biol Chem 277:21585-91. 2002
    ..We conclude that Nse1p and the SMC5-SMC6 heterodimer together form a high molecular mass complex that is conserved in eukaryotes and required for both DNA repair and proliferation...
  36. pmc Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury
    Masahiko Abematsu
    Laboratory of Molecular Neuroscience, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
    J Clin Invest 120:3255-66. 2010
    ..These findings raise the possibility that epigenetic status in transplanted NSCs can be manipulated to provide effective treatment for SCI...
  37. ncbi request reprint [How is ER stress sensed?]
    Yukio Kimata
    Tanpakushitsu Kakusan Koso 49:998-1001. 2004
  38. ncbi request reprint Isolation and characterization of a putative transducer of endoplasmic reticulum stress in Oryza sativa
    Yoko Okushima
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma 630 0101 Japan
    Plant Cell Physiol 43:532-9. 2002
    ..When produced in bacteria as a fusion protein, the C-terminal region of OsIre1 showed autophosphorylation activity. These results thus indicate that OsIre1 encodes a putative plant transducer of ER stress...
  39. ncbi request reprint [Translational regulation in stress response]
    Akira Hosoda
    Tanpakushitsu Kakusan Koso 48:375-81. 2003
  40. ncbi request reprint A transgenic mouse model for monitoring endoplasmic reticulum stress
    Takao Iwawaki
    Laboratory for Cell Recovery Mechanisms, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Med 10:98-102. 2004
    ..We used transgenic animals expressing the ER stress indicator to show that it can be used to monitor physiological and pathological ER stress in vivo...
  41. ncbi request reprint Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy
    Shinichi Kiso
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Gastroenterology 124:701-7. 2003
    ..This study describes the effects of HB-EGF on liver regeneration after 70% partial hepatectomy in proHB-EGF transgenic mice with liver-specific expression...
  42. ncbi request reprint Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene
    Bryan L Wharram
    University of Michigan Health System, Division of Nephrology, Department of Internal Medicine, 1570 MSRBII, Box 0676, Ann Arbor, MI 48109 0676, USA
    J Am Soc Nephrol 16:2941-52. 2005
    ..This model system provides strong support for the concept that podocyte depletion could be a major mechanism driving glomerulosclerosis and progressive loss of renal function in human glomerular diseases...
  43. ncbi request reprint Conditional ablation of mature olfactory sensory neurons mediated by diphtheria toxin receptor
    Huaiyang Chen
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616, USA
    J Neurocytol 34:37-47. 2005
    ..These data validate the hypothesis that OMP-DTR mice can be used as a tool to ablate the mature olfactory sensory neurons in a controlled fashion and to study the regulatory mechanisms of the neuronal replacement...
  44. ncbi request reprint Protective role of macrophages in noninflammatory lung injury caused by selective ablation of alveolar epithelial type II Cells
    Yasunobu Miyake
    Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    J Immunol 178:5001-9. 2007
    ..These results indicate that macrophages play a protective role in noninflammatory lung injury caused by the selective ablation of AE2 cells...
  45. ncbi request reprint Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice
    Kazutomi Yoshiuchi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 366:545-50. 2008
    ..In addition, our present results suggest that ERAI transgenic mice are very useful for evaluating in vivo ER stress, especially in the liver, during the development of insulin resistance...
  46. ncbi request reprint Recent advances in understanding the unfolded protein response
    Martin Schroder
    Antioxid Redox Signal 9:2241-4. 2007