Hiroshi Kobayashi

Summary

Affiliation: Nara Medical University
Country: Japan

Publications

  1. ncbi request reprint Prevalence of ovarian cancer among women with a CA125 level of 35 U/ml or less
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan
    Gynecol Obstet Invest 65:133-8. 2008
  2. ncbi request reprint A randomized study of screening for ovarian cancer: a multicenter study in Japan
    H Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Int J Gynecol Cancer 18:414-20. 2008
  3. doi request reprint The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Japan
    Int J Gynecol Cancer 19:471-9. 2009
  4. ncbi request reprint Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review)
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara 634 8522, Japan
    Oncol Rep 22:233-40. 2009
  5. doi request reprint Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    Int J Clin Oncol 14:378-82. 2009
  6. doi request reprint Fetal programming theory: implication for the understanding of endometriosis
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan Electronic address
    Hum Immunol 75:208-17. 2014
  7. ncbi request reprint Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan
    H Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Int J Gynecol Cancer 17:37-43. 2007
  8. ncbi request reprint Endogenous anti-inflammatory substances, inter-alpha-inhibitor and bikunin
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Biol Chem 387:1545-9. 2006
  9. ncbi request reprint Serum CA125 level before the development of ovarian cancer
    H Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Shijo cho, Kashihara, Nara, Japan
    Int J Gynaecol Obstet 99:95-9. 2007
  10. doi request reprint The role of iron in the pathogenesis of endometriosis
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
    Gynecol Endocrinol 25:39-52. 2009

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Prevalence of ovarian cancer among women with a CA125 level of 35 U/ml or less
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan
    Gynecol Obstet Invest 65:133-8. 2008
    ..We investigated the prevalence of ovarian cancer among women in the Shizuoka Cohort Study on Ovarian Cancer Screening (SCSOCS) trial who had an abnormal ultrasound (US) and a CA125 level of 35 U/ml or less...
  2. ncbi request reprint A randomized study of screening for ovarian cancer: a multicenter study in Japan
    H Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Int J Gynecol Cancer 18:414-20. 2008
    ..The rise in the detection of early-stage ovarian cancer in asymptomatic postmenopausal women is not significant, but future decisions on screening policy should be informed by further follow-up from this trial...
  3. doi request reprint The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Japan
    Int J Gynecol Cancer 19:471-9. 2009
    ..They comprise approximately 20% of all EOC. Understanding the mechanisms of CCC development and elucidating pathogenesis and pathophysiology are intrinsic to prevention and effective therapies for CCC...
  4. ncbi request reprint Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review)
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara 634 8522, Japan
    Oncol Rep 22:233-40. 2009
    ..The molecular pathology of CCC is heterogeneous and involves various putative precursor lesions and multiple pathways of development, possibly via genetic alteration by oxidative stress...
  5. doi request reprint Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    Int J Clin Oncol 14:378-82. 2009
    ..Understanding the mechanisms of the development of endometriosis and elucidating its pathogenesis and pathophysiology are intrinsic to the prevention of endometriosis-associated ovarian cancer and the search for effective therapies...
  6. doi request reprint Fetal programming theory: implication for the understanding of endometriosis
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan Electronic address
    Hum Immunol 75:208-17. 2014
    ..Future study will identify the putative mechanisms relating epigenetic changes of decidualization susceptibility genes in early life to the risk of developing endometriosis in adulthood. ..
  7. ncbi request reprint Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan
    H Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Int J Gynecol Cancer 17:37-43. 2007
    ..2 (95% CI = 6.90-20.9) in women above 50 years of age. Our findings for the first time support the hypothesis that ovarian endometrioma increases the subsequent risk of developing ovarian cancer in Shizuoka, Japan...
  8. ncbi request reprint Endogenous anti-inflammatory substances, inter-alpha-inhibitor and bikunin
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Biol Chem 387:1545-9. 2006
    ..This brief review largely focuses on our current understanding of the apparent functions of bikunin, its ligands, the effector molecules with which it interacts, and its regulation...
  9. ncbi request reprint Serum CA125 level before the development of ovarian cancer
    H Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Shijo cho, Kashihara, Nara, Japan
    Int J Gynaecol Obstet 99:95-9. 2007
    ..Little is known about the natural history of ovarian cancer with respect to the change of serum CA125 level...
  10. doi request reprint The role of iron in the pathogenesis of endometriosis
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
    Gynecol Endocrinol 25:39-52. 2009
    ..Understanding the mechanisms of endometriosis development and elucidating its pathogenesis and pathophysiology are intrinsic to prevention and the search for effective therapies...
  11. ncbi request reprint Risk of carcinoma in women with ovarian endometrioma
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    Front Biosci (Elite Ed) 3:529-39. 2011
    ..This review summarizes recent advances in the understanding of epidemiology, carcinogenesis, pathogenesis, and pathophysiology of endometriosis-associated EOC; and a possible novel model is proposed...
  12. ncbi request reprint Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase
    Mika Suzuki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka 431 3192, Japan
    J Biol Chem 279:14899-908. 2004
    ..5) When the AS-matriptase-treated cells were injected intraperitoneally into nude mice, the mice developed smaller tumors. Our data identify a novel role for matriptase for activation of receptor-bound uPA...
  13. ncbi request reprint Suppression of lipopolysaccharide-induced cytokine production of gingival fibroblasts by a soybean, Kunitz trypsin inhibitor
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    J Periodontal Res 40:461-8. 2005
    ..Human bikunin, a Kunitz-type trypsin inhibitor, inhibits inflammation by down-regulating the expression of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) in tumor cells and inflammatory cells...
  14. ncbi request reprint Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis
    Yoshiko Tanaka
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Int J Cancer 109:336-47. 2004
    ..IGF-I-induced IGFBP-4 proteolysis by PAPP-A may enhance cell growth and invasion through IGF-I-dependent Akt and ERK1/2 activation and subsequently upregulation of uPA...
  15. ncbi request reprint A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Clin Exp Metastasis 21:159-66. 2004
    ..In conclusion, KTI, but not BBI, could inhibit cell invasiveness at least through suppression of uPA signaling cascade, although the mechanisms of KTI may be different from those of bikunin...
  16. ncbi request reprint Dietary supplementation of soybean kunitz trypsin inhibitor reduces lipopolysaccharide-induced lethality in mouse model
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, 431 3192, Japan
    Shock 23:441-7. 2005
    ..p. injection and dietary supplementation of a soybean KTI may play a role as a potent anti-inflammatory agent by inhibiting activation of MAP kinases, leading to the suppression of cytokine expression...
  17. ncbi request reprint Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin
    Mika Suzuki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Int J Cancer 104:289-302. 2003
    ..We conclude that transfection of HRA cells with the bik cDNA constitutively suppresses ERK1/2 activation, which results in inhibition of uPA expression and subsequently reduces dissemination of bik(+) clones...
  18. ncbi request reprint CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Int J Cancer 102:379-89. 2002
    ....
  19. ncbi request reprint Bikunin target genes in ovarian cancer cells identified by microarray analysis
    Mika Suzuki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka 431 3192, Japan
    J Biol Chem 278:14640-6. 2003
    ..Further, genetic inhibition of matriptase or PAPP-A could lead to diminished invasion. These results show that bikunin alters the pattern of gene expression in HRA cells leading to a block in cell invasion...
  20. ncbi request reprint Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, 431 3192, Japan
    J Biol Chem 279:6371-9. 2004
    ..We conclude that PI3K plays an essential role in promoting uPA-mediated invasive phenotype in HRA cells. Our data identify a novel role for PI3K as a bikunin target gene on uPA up-regulation and invasion...
  21. ncbi request reprint Suppression of urokinase receptor expression by thalidomide is associated with inhibition of nuclear factor kappaB activation and subsequently suppressed ovarian cancer dissemination
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, Japan
    Cancer Res 65:10464-71. 2005
    ..Furthermore, combination therapy with thalidomide plus paclitaxel may be an effective way to markedly reduce i.p. tumor growth and ascites in ovarian cancer dissemination...
  22. ncbi request reprint Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka 431 3192, Japan
    J Cancer Res Clin Oncol 131:527-38. 2005
    ..The Basidiomycete fungus Agaricus blazei Murill has traditionally been used as a health food for the prevention of cancer...
  23. ncbi request reprint Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells
    Yasuyuki Hirashima
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka 431 3192, Japan
    J Biol Chem 278:26793-802. 2003
    ..This represents a novel pathway by which tumor cells can regulate the plasminogen activator system-dependent cellular responses in mesothelial cells that may contribute to formation of peritoneal dissemination of ovarian cancer...
  24. doi request reprint Molecular structure and function analysis of bikunin on down-regulation of tumor necrosis factor-alpha expression in activated neutrophils
    Seiji Kanayama
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Nara, Kashihara 634 8522, Japan
    Cytokine 42:191-7. 2008
    ..We performed a detailed molecular analysis of bikunin-mediated anti-inflammation (suppressive effect of cytokine release, MAP kinase activation, and nuclear translocation of NF-kB) using a truncated form of bikunin...
  25. ncbi request reprint Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Int J Cancer 112:519-24. 2004
    ....
  26. ncbi request reprint Bikunin suppresses expression of pro-inflammatory cytokines induced by lipopolysaccharide in neutrophils
    Seiji Kanayama
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    J Endotoxin Res 13:369-76. 2007
    ..These data suggest that such effects are important in vivo and play a major contributory role in abrogation of neutrophil-mediated inflammatory responses, such as preterm delivery...
  27. ncbi request reprint A soybean Kunitz trypsin inhibitor reduces tumor necrosis factor-alpha production in ultraviolet-exposed primary human keratinocytes
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Shizuoka, Japan
    Exp Dermatol 14:765-74. 2005
    ..A soybean Kunitz trypsin inhibitor (KTI) down-regulates the expression of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) in tumor cells and inflammatory cells...
  28. ncbi request reprint Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro
    Yuji Takei
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Int J Cancer 113:54-8. 2005
    ..The above findings suggest the applicability of therapeutic strategies targeting the inhibition of peritoneal invasion and dissemination of ovarian cancer by the use of the chimeric gene ATF-HI8...
  29. ncbi request reprint Bikunin plus paclitaxel markedly reduces tumor burden and ascites in mouse model of ovarian cancer
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka 431 3192, Japan
    Int J Cancer 110:134-9. 2004
    ..In conclusion, combination therapy with bikunin plus paclitaxel may be an effective way to markedly reduce i.p. tumor growth and ascites in ovarian carcinoma possibly through suppression of uPA, uPAR, VEGF and bFGF expression...
  30. doi request reprint Molecular mechanisms linking endometriosis under oxidative stress with ovarian tumorigenesis and therapeutic modalities
    Hiroshi Shigetomi
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Cancer Invest 30:473-80. 2012
    ..HNF-1beta appears to play a key role in anti-oxidative defense mechanisms. We discuss the pathophysiologic roles of oxidative stress as somatic mutations as well as highly specific agents that effectively modulate these targets...
  31. doi request reprint Peritoneal disseminated recurrence and lung metastasis after surgery for stage IA uterine papillary serous carcinoma of the endometrium: a case report
    Seiji Kanayama
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Arch Gynecol Obstet 278:277-80. 2008
    ..We describe a case of synchronous peritoneal dissemination and multiple lung metastases after surgery for stage IA primary uterine papillary serous carcinoma (UPSC) of the endometrium, revealed by an uncontrollable retention of ascites...
  32. doi request reprint Peripheral RAGE (receptor for advanced glycation endproducts)-ligands in normal pregnancy and preeclampsia: novel markers of inflammatory response
    Katsuhiko Naruse
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    J Reprod Immunol 93:69-74. 2012
    ..0005). Our data suggest that patterns of serum RAGE ligand concentration indicate different inflammatory pathways in normal pregnancy, EO-PE, and LO-PE...
  33. doi request reprint Biological and clinical significance of NAC1 expression in cervical carcinomas: a comparative study between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane 6938501, Japan
    Hum Pathol 43:506-19. 2012
    ..Therefore, cervical carcinoma patients with NAC1 expression may benefit from a targeted therapy irrespective of histologic type...
  34. doi request reprint Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary
    Yoshihiko Yamada
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Int J Gynecol Cancer 21:1200-7. 2011
    ..The aim of our review was to identify and synthesize the most current information on CCC with regard to molecular and pathophysiological distinctions...
  35. doi request reprint Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells
    Yoriko Yoshizawa
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Oncol Rep 26:957-64. 2011
    ....
  36. ncbi request reprint Hepatocyte growth factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial cancer cells
    Seiji Kanayama
    Department of Obstetrics and Gynecology, Nara Medical University, Nara 634 8522, Japan
    Oncol Rep 19:117-22. 2008
    ..Our data suggest that HGF induces anoikis resistance in endometrial cancer cells possibly through PI3K/Akt pathway-dependent up-regulation of COX-2 expression...
  37. doi request reprint New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal
    Hirotaka Kajihara
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Gynecol Endocrinol 27:73-9. 2011
    ..We have recently showed that the upregulated genes were predominantly clustered in stress and detoxification, providing a mechanistic explanation for the oxidative stress and chronic inflammatory response in endometriosis...
  38. ncbi request reprint Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells
    Guang Wei Sun
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Endocrinology 144:793-801. 2003
    ..Our study represents the first report that FSH amplifies IGF-I-mediated Crtl1 production, possibly via PI3-K-Akt signaling cascades in rat granulosa cells...
  39. ncbi request reprint Clear cell carcinoma of the ovary: potential pathogenic mechanisms (Review)
    Hirotaka Kajihara
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Oncol Rep 23:1193-203. 2010
    ..A redox-sensitive subset of cEOC genes linked to oxidative and detoxification pathways was identified and associated with HNF-1beta-specific downstream targets...
  40. ncbi request reprint Reproductive failure in mice lacking inter-alpha-trypsin inhibitor (ITI)--ITI target genes in mouse ovary identified by microarray analysis
    Mika Suzuki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, 431 3192, Japan
    J Endocrinol 183:29-38. 2004
    ..These studies demonstrate that proteins of the ITI family may exert potent regulatory effects on a major physiological reproductive process, ovulation...
  41. doi request reprint Iron-dependent oxidative stress as a pathogenesis for preterm birth
    Mariko Sakata
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Obstet Gynecol Surv 63:651-60. 2008
    ..Understanding the mechanisms of the development of PTB and elucidating pathogenesis and pathophysiology are intrinsic to prevention and effective therapies for this disorder...
  42. doi request reprint Expression profiles of genes involved in poor prognosis of epithelial ovarian carcinoma: a review
    Shozo Yoshida
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
    Int J Gynecol Cancer 19:992-7. 2009
    ..Epithelial ovarian cancer (EOC) is the commonest cause of gynecological cancer-related mortality. Although the prognosis for patients with advanced cancer is poor, there is a wide range of outcomes for individual patients...
  43. doi request reprint New insights into pattern recognition receptors and their ligands in gynecologic pathologies
    Yoshihiko Yamada
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Hum Immunol 72:213-8. 2011
    ..Upregulation of PRRs expression may synergize with activation of HNF-1β signaling to accelerate endometriosis proliferation and cause carcinogenesis...
  44. doi request reprint Two cases of pregnant women with ovarian endometrioma mimicking a malignant ovarian tumor
    Shozo Yoshida
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    J Clin Ultrasound 36:512-6. 2008
    ..The sonographic and MR imaging findings mimicked ovarian cancer. Surgical intervention may still be inevitable to exclude the possibility of malignancy...
  45. ncbi request reprint Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells
    Yoshiko Tanaka
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, 431 3192, Japan
    J Biol Chem 279:8567-76. 2004
    ..Taken together, these data support a role for TGF-beta1 activation of two distinct pathways (Src-MAPK-PI3K-NF-kappaB-dependent and Src-MAPK-AP-1-dependent) for TGF-beta1-dependent uPA up-regulation and promotion of invasion...
  46. doi request reprint Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain
    Hiroshi Shigetomi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    Inflamm Res 59:679-87. 2010
    ..In this review we have tried to summarize recent findings on the Kunitz family of serine proteinase inhibitors and their implications in health and disease...
  47. doi request reprint Theoretical model of treatment strategies for clear cell carcinoma of the ovary: focus on perspectives
    Shozo Yoshida
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Cancer Treat Rev 35:608-15. 2009
    ..The aim of this review is to summarize the current knowledge and future perspective on the new therapeutic targets and treatment strategies for CCC...
  48. ncbi request reprint Upregulation of bikunin in tumor-infiltrating macrophages as a factor of favorable prognosis in ovarian cancer
    Yoshiko Tanaka
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Gynecol Oncol 94:725-34. 2004
    ..This study was carried out to clarify the localization of bikunin, a Kunitz-type protease inhibitor, and relation between expression of individual bikunin protein and ovarian cancer progression...
  49. pmc Evidence for activation of Toll-like receptor and receptor for advanced glycation end products in preterm birth
    Taketoshi Noguchi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    Mediators Inflamm 2010:490406. 2010
    ..In the present study, we reviewed TLR and RAGE expression, their ligands, and signaling in preterm birth...
  50. doi request reprint Inflammatory pattern recognition receptors and their ligands: factors contributing to the pathogenesis of preeclampsia
    Toshiyuki Sado
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Inflamm Res 60:509-20. 2011
    ..Preeclampsia lacks effective therapies because of the poor understanding of disease pathogenesis. The aim of this paper is to review molecular signaling pathways that could be responsible for the pathogenesis of preeclampsia...
  51. doi request reprint Molecular genetics and epidemiology of epithelial ovarian cancer (Review)
    Shoji Haruta
    Department of Obstetrics and Gynecology, Nara Medical University, Nara 634 8522, Japan
    Oncol Rep 26:1347-56. 2011
    ..This review focuses on current knowledge of the genetic and environmental factors affecting the development of EOC, and outlines future challenges in its pathogenesis research...
  52. ncbi request reprint Reduced bikunin gene expression as a factor of poor prognosis in ovarian carcinoma
    Yoshiko Tanaka
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Cancer 98:424-30. 2003
    ..This study was carried out to clarify the relation between the expression of individual bikunin mRNA and tumor progression...
  53. ncbi request reprint Ovarian endometrioma--risks factors of ovarian cancer development
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
    Eur J Obstet Gynecol Reprod Biol 138:187-93. 2008
    ..We also analyzed whether the predisposition toward ovarian cancer is limited to endometrioid and clear cell carcinoma...
  54. ncbi request reprint A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-beta 1 signaling cascade
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Shizuoka, 431 3192, Japan
    J Biol Chem 278:7790-9. 2003
    ..In conclusion, bikunin could inhibit the constitutive expression of TGF-beta1 and TGF-beta1-mediated, Src- and ERK-dependent, PA system signaling cascade, at least in part, through inhibition of a non-voltage-sensitive calcium channel...
  55. doi request reprint Giant abdominal tumor of the ovary
    Sachiyo Ueda
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    J Obstet Gynaecol Res 34:108-11. 2008
    ..The patient underwent left salpingo-oophorectomy. Histology revealed a serous cystadenoma of the ovary. Systemic hemodynamics were sequentially measured during the perioperative period. The patient is now well...
  56. ncbi request reprint Aging impairs the protective effect of magnesium supplementation on hypertension in spontaneously hypertensive rats
    Toshiyuki Sado
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Magnes Res 20:196-9. 2007
    ..Mg2+ supplementation does not exert antihypertensive effects in the WKY rats. In conclusion, Mg2+ supplementation may provide beneficial effect in the developmental phase of hypertension but not in established hypertension...
  57. ncbi request reprint Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Cancer 100:869-77. 2004
    ..Bikunin, a Kunitz-type protease inhibitor, specifically inhibits tumor invasion and metastasis...
  58. ncbi request reprint Late onset of pulmonary embolism caused by lymphocyst following pelvic lymphadenectomy
    Yoriko Tsuji
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    J Obstet Gynaecol Res 33:734-8. 2007
    ..This case strongly suggests that prolonged postoperative thromboembolic prophylaxis should be considered in elderly patients undergoing lymphocyst following pelvic surgery...
  59. doi request reprint A potential link of oxidative stress and cell cycle regulation for development of endometriosis
    Hiroshi Shigetomi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    Gynecol Endocrinol 28:897-902. 2012
    ..To review the contemporary literature on potential factors and their signaling pathways that support prolonged survival of endometriotic cells...
  60. pmc A case of early-stage ovarian carcinoid tumor metastasized to the liver
    Seiji Kanayama
    Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo Cho, Nara, Kashihara 634 8522, Japan
    Case Rep Obstet Gynecol 2012:961087. 2012
    ..Our paper suggests that chemoembolization with cisplatin may be effective in treatment of patients with multiple liver metastases of ovarian carcinoid tumor...
  61. doi request reprint Antiangiogenic-induced hypertension: the molecular basis of signaling network
    Akira Nagai
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan
    Gynecol Obstet Invest 73:89-98. 2012
    ..The aim of this paper is to summarize recent advances in VEGF-mediated signaling and the target molecules, and provide new insights into treatment strategies for preeclampsia...
  62. doi request reprint Loss of ARID1A expression is related to shorter progression-free survival and chemoresistance in ovarian clear cell carcinoma
    Atsuko Katagiri
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Mod Pathol 25:282-8. 2012
    ..Measurement of ARID1A expression may be a method to predict resistance to platinum-based chemotherapy in patients with ovarian clear cell carcinoma...
  63. pmc Chemokine and free fatty acid levels in insulin-resistant state of successful pregnancy: a preliminary observation
    Katsuhiko Naruse
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara City, Nara, Japan
    Mediators Inflamm 2012:432575. 2012
    ..These results suggest that the reduced MCP-1 concentration in normal pregnancy may be a pathway to inhibit the induction of pathological features from physiological insulin resistance and homeostatic inflammation...
  64. doi request reprint Clinicopathologic features of ovarian cancer in patients with ovarian endometrioma
    Ryuji Kawaguchi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan
    J Obstet Gynaecol Res 34:872-7. 2008
    ..The purpose of this study was to describe the clinicopathologic features of malignant transformation in patients with ovarian endometrioma, their treatment and outcome in the Kinki region, Japan...
  65. doi request reprint Anticytokine therapy in preterm labor: current knowledge and future perspectives
    Toshiyuki Sado
    Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
    Gynecol Obstet Invest 71:1-10. 2011
    ..Conclusion: Anticytokine therapy is ready for the clinic...
  66. ncbi request reprint The protease inhibitor bikunin, a novel anti-metastatic agent
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, 431 3192, Japan
    Biol Chem 384:749-54. 2003
    ....
  67. ncbi request reprint Link protein as an enhancer of cumulus cell-oocyte complex expansion
    Guang Wei Sun
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Shizuoka, Japan
    Mol Reprod Dev 63:223-31. 2002
    ..Therefore, in vitro, LP might serve, in part, to enhance the COC expansion possibly by stabilizing HA-I alpha I (or heavy chains) complex on the surrounding cumulus cell matrices...
  68. ncbi request reprint CD44 stimulation by fragmented hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells
    Mika Suzuki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1 20 1, Handacho 3600, Hamamatsu, Shizuoka 431 3192, Japan
    Biochim Biophys Acta 1591:37-44. 2002
    ..Taken together, these studies establish a signal transduction cascade or cross-talk emanating from CD44 to c-Met...
  69. ncbi request reprint Massive ovarian edema in pregnancy after ovulation induction using clomiphene citrate
    Ryuji Kawaguchi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, 634 8522, Japan
    Arch Gynecol Obstet 277:375-8. 2008
    ..Massive ovarian edema is a benign enlargement of the ovary caused by accumulation of fluid occurring mainly in young women. Most cases are thought to result from venous and lymphatic obstruction...
  70. doi request reprint Fatal factors of clinical manifestations and laboratory testing in patients with amniotic fluid embolism
    Hidekazu Oi
    Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan
    Gynecol Obstet Invest 70:138-44. 2010
    ..To identify factors leading to fatality of patients with amniotic fluid embolism (AFE)...
  71. ncbi request reprint The usefulness of photodynamic eye for sentinel lymph node identification in patients with cervical cancer
    Naoto Furukawa
    Department of Obstetrics and Gynecology, Nara Medical University 840 Shijo cho, Kashihara, Nara 634 8522, Japan
    Tumori 96:936-40. 2010
    ..We studied the potential use of sentinel lymph node identification using a near-infrared fluorescence imaging technique in the treatment of cervical cancer...
  72. doi request reprint Expression of nuclear Notch3 in cervical squamous cell carcinomas and its association with adverse clinical outcomes
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, 6938501, Japan
    Gynecol Oncol 117:409-16. 2010
    ..The aim of this study was to clarify the functional role of Notch3 in human cervical carcinomas...
  73. doi request reprint Metoclopramide does not prolong duration of action of landiolol attenuating the hemodynamic response to induction of anesthesia and tracheal intubation
    Satoki Inoue
    Department of Anesthesiology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    J Anesth 24:649-52. 2010
    ..However, changes in blood pressure were not affected. Metoclopramide at induction of anesthesia did not prolong duration of action of landiolol attenuating the hemodynamic response to induction of anesthesia and tracheal intubation...
  74. ncbi request reprint Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade
    Hiroshi Kobayashi
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Eur J Biochem 269:3945-57. 2002
    ....
  75. ncbi request reprint Thymidine phosphorylase expression in tumor-infiltrating macrophages may be correlated with poor prognosis in uterine endometrial cancer
    Yoshiko Tanaka
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Hum Pathol 33:1105-13. 2002
    ....
  76. ncbi request reprint Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells
    Mika Suzuki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handacho 3600, Hamamatsu, Shizuoka, 431 3192, Japan
    J Biol Chem 277:8022-32. 2002
    ....
  77. pmc Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages
    Hidenori Matsuzaki
    Netforce Co Ltd, Taiko, Japan
    Clin Diagn Lab Immunol 11:1140-7. 2004
    ..Bikunin might be a candidate for the treatment of inflammation, including septic shock...
  78. ncbi request reprint [Case of herpes zoster ophthalmicus with abducent palsy: the cause and magnetic resonance imaging findings]
    Keiichiro Iwao
    Department of Ophthalmology, Faculty of Medicine, Saga University, Japan
    Nihon Ganka Gakkai Zasshi 110:193-8. 2006
    ..To report the cause and magnetic resonance imaging (MRI) findings in a case of abducent palsy following herpes zoster ophthalmicus...
  79. ncbi request reprint Hepatocellular carcinoma with mesothelioma-like dissemination
    Yoshiro Otsuki
    Department of Pathology, Seirei Hamamatsu General Hospital, Japan
    Pathol Int 55:738-44. 2005
    ..The origin of this tumor and its differential diagnosis (malignant mesothelioma, hepatoid adenocarcinoma, and hepatoid yolk sac tumor) are discussed...
  80. ncbi request reprint Reduced syndecan-1 expression stimulates heparin-binding growth factor-mediated invasion in ovarian cancer cells in a urokinase-independent mechanism
    Hidenori Matsuzaki
    Netforce Co Ltd, Taiko 3 1 18, Nakamura, Nagoya, Aichi 453 0801, Japan
    Oncol Rep 14:449-57. 2005
    ..Taken together, these data suggest that decreased syndecan-1 expression may be associated with enhanced cell invasion possibly through the uPA-independent mechanism...
  81. ncbi request reprint Plasma bikunin as a favorable prognostic factor in ovarian cancer
    Hidenori Matsuzaki
    Netforce Co Ltd, Nakamura, Aichi, Japan
    J Clin Oncol 23:1463-72. 2005
    ..The high bikunin expression in ovarian cancer tissue would enable the use of soluble bikunin protein present in the circulation of ovarian cancer patients as a biomarker of disease...
  82. ncbi request reprint Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophages
    Kiyoshi Wakahara
    NetForce Co, Ltd, Aichi, Japan
    J Infect Dis 191:930-8. 2005
    ..Lipopolysaccharide (LPS) is the primary mediator of gram-negative sepsis; it induces the production of macrophage-derived cytokines. It has been shown that bikunin, a Kunitz-type protease inhibitor, inhibits LPS-induced cytokine expression...
  83. ncbi request reprint A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-beta and subsequently suppresses TGF-beta signalings
    Tatsuo Yagyu
    Netforce Co Ltd, Taiko 3 1 18, Nakamura, Nagoya, Aichi 453 0801, Japan
    FEBS Lett 576:408-16. 2004
    ....
  84. ncbi request reprint Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation
    Tatsuo Yagyu
    Netforce Co Ltd, Nagoya, Aichi, Japan
    J Clin Endocrinol Metab 90:3017-21. 2005
    ..However, the mechanism of Thal action in human endometriotic stromal cells has not yet been elucidated...
  85. ncbi request reprint Systemic sclerosis and pseudomesotheliomatous adenocarcinoma of the lung
    Ryusuke Yoshimi
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Mod Rheumatol 16:165-8. 2006
    ..This is the first case report of SSc with PMA...
  86. ncbi request reprint Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells
    Kiyoshi Wakahara
    Netforce Co Ltd, Taiko 3 1 18, Nakamura, Nagoya, Aichi 453 0801, Japan
    J Cell Biochem 93:437-53. 2004
    ..These data also reflect the complex biological effect of uPA-PAI-1 system...
  87. pmc Particle simulation approach for subcellular dynamics and interactions of biological molecules
    Ryuzo Azuma
    RIKEN Genomic Sciences Center, 1 7 22 Suehiro Tsurumi, Yokohama, Kanagawa, 230 0045, Japan
    BMC Bioinformatics 7:S20. 2006
    ..However, little is known concerning how molecular-level dynamics affect properties at the cellular level...
  88. ncbi request reprint Enhanced immunoresponse of antibody/mixed-PEG co-immobilized surface construction of high-performance immunomagnetic ELISA system
    Yukio Nagasaki
    Tsukuba Research Center for Interdisciplinary Materials Science, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8573, Japan
    J Colloid Interface Sci 309:524-30. 2007
    ..Actually, when alpha-fetoprotein was analyzed by the magnetic bead-assisted ELISA thus constructed, the S/N ratio was about 20-fold higher for the mixed coating with PEG (6 kDa):PEG (2.5 kDa)=9:1, compared to the conventional BSA...
  89. ncbi request reprint Reduction of serum soluble CD26/dipeptidyl peptidase IV enzyme activity and its correlation with disease activity in systemic lupus erythematosus
    Hiroshi Kobayashi
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Japan
    J Rheumatol 29:1858-66. 2002
    ..To determine the role of soluble CD26 (sCD26) in the pathophysiology of patients with systemic lupus erythematosus (SLE), we measured levels of sCD26 and its specific DPPIV activity in serum...
  90. ncbi request reprint Preventive effect of fermented brown rice and rice bran on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats
    Hiroyuki Tomita
    Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 19:11-5. 2008
    ..These results indicate that FBRA inhibits MNNG-induced development of gastric tumors by administration during the post-initiation phase in rats. FBRA is regarded as a promising dietary agent for the prevention of human gastric cancer...
  91. ncbi request reprint Preventive effect of fermented brown rice and rice bran against colon carcinogenesis in male F344 rats
    Masaki Katyama
    Department of Pathology, Gifu University School of Medicine, Gifu 500 8705, Japan
    Oncol Rep 9:817-22. 2002
    ..05). These observations demonstrated for the first time that FBRA inhibits colon tumor development in rats, and suggest that it is a promising dietary supplement for prevention of human colon cancer...
  92. ncbi request reprint [Functional community pharmaceutical service for university hospital outpatients with glaucoma]
    Hiroshi Kobayashi
    Nihon Ganka Gakkai Zasshi 111:759-61. 2007
  93. ncbi request reprint Localization and activity of membrane dipeptidase in bovine ciliary epithelium
    Hiromi Ikeda
    Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 44:37-43. 2003
    ..To investigate the localization and the activity of membrane dipeptidase (MDP) in the bovine eye...
  94. ncbi request reprint A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma
    Hiroshi Kobayashi
    Department of Ophthalmology, Saga Medical School, 5 1 1 Nabeshima, 849 8501 Saga, Japan
    Graefes Arch Clin Exp Ophthalmol 241:359-66. 2003
    ..To compare the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C...
  95. ncbi request reprint Preventive effect of fermented brown rice and rice bran on diethylnitrosoamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats
    Masaki Katayama
    Department of Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Oncol Rep 10:875-80. 2003
    ..5+/-0.6 vs. 0.2+/-0.4 and 0.1+/-0.3, respectively). These data prove that FBRA has an inhibitory effect on the hepatocarcinogenesis in rats. FBRA could be a promising chemopreventive agent for human liver as well as colorectal neoplasia...
  96. ncbi request reprint "One step" for cancer prevention
    Hiroshi Kobayashi
    Sapporo Cancer Seminar Foundation, Hokkaido Medical Assoc Sapporo 060 0042, Japan
    Asian Pac J Cancer Prev 7:672-8. 2006
  97. ncbi request reprint CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka
    Zeki Topcu
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Department of Oral Patho biological Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 23:595-8. 2002
    ..03-0.72). In the allelic base analysis, there was also a significant decrease in the OR of the deletion allele. Our data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces oral cancer risk in betel quid chewers...
  98. doi request reprint Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases
    Masanori Hisaoka
    Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Am J Surg Pathol 32:452-60. 2008
    ..In cases with unusual histologic findings, molecular detection of the EWSR1-ATF1/CREB1 fusion genes provides critical information regarding the diagnosis of the tumor...