H Iwao

Summary

Affiliation: Nara Institute of Science and Technology
Country: Japan

Publications

  1. pmc Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
    S Yamanaka
    Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma 630 0101, Nara, Japan
    EMBO J 19:5533-41. 2000
  2. ncbi request reprint Gene transfer of dominant-negative mutants of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase prevents neointimal formation in balloon-injured rat artery
    Y Izumi
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Circ Res 88:1120-6. 2001
  3. ncbi request reprint Dominant negative c-jun gene transfer inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in rats
    H Yasumoto
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Gene Ther 8:1682-9. 2001
  4. ncbi request reprint Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer
    R Suto
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Gene Ther 11:187-93. 2004
  5. ncbi request reprint Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells
    K Tominaga
    Department of Gastroenterology, Osaka City University, Graduate School of Medicine, Osaka, Japan
    Aliment Pharmacol Ther 20:143-50. 2004
  6. pmc Angiotensin converting enzyme inhibitor prevents left ventricular remodelling after myocardial infarction in angiotensin II type 1 receptor knockout mice
    M Yoshiyama
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Heart 91:1080-5. 2005
  7. ncbi request reprint Dominant-negative c-Jun inhibits rat cardiac hypertrophy induced by angiotensin II and hypertension
    S Kim-Mitsuyama
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Gene Ther 13:348-55. 2006

Collaborators

Detail Information

Publications7

  1. pmc Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
    S Yamanaka
    Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma 630 0101, Nara, Japan
    EMBO J 19:5533-41. 2000
    ..Transcription from synthetic retinoic acid-responsive elements was also impaired. These data demonstrated that this translation initiation factor homolog controls specific gene expression pathways required for cellular differentiation...
  2. ncbi request reprint Gene transfer of dominant-negative mutants of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase prevents neointimal formation in balloon-injured rat artery
    Y Izumi
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Circ Res 88:1120-6. 2001
    ..Thus, ERK and JNK activation triggers SMC proliferation, leading to neointimal formation. These kinases may be the new therapeutic targets for prevention of vascular diseases...
  3. ncbi request reprint Dominant negative c-jun gene transfer inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in rats
    H Yasumoto
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Gene Ther 8:1682-9. 2001
    ..Thus, AP-1 seems to be the new therapeutic target for treatment of vascular diseases...
  4. ncbi request reprint Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer
    R Suto
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Gene Ther 11:187-93. 2004
    ..We obtained the first evidence that DN-c-Jun gene transfer exerted a significant antitumor effect on colon cancer both in vitro and in vivo. DN-c-Jun gene transfer may be a new candidate for treatment of colorectal cancer...
  5. ncbi request reprint Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells
    K Tominaga
    Department of Gastroenterology, Osaka City University, Graduate School of Medicine, Osaka, Japan
    Aliment Pharmacol Ther 20:143-50. 2004
    ..However, the correlation between respective MAP kinase signals and COX-2 in the proliferation of gastric and colon cancer cells has not been well elucidated...
  6. pmc Angiotensin converting enzyme inhibitor prevents left ventricular remodelling after myocardial infarction in angiotensin II type 1 receptor knockout mice
    M Yoshiyama
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Heart 91:1080-5. 2005
    ..However, it is still not clear whether inhibition of the AT1 receptor is enough to prevent LV remodelling after MI...
  7. ncbi request reprint Dominant-negative c-Jun inhibits rat cardiac hypertrophy induced by angiotensin II and hypertension
    S Kim-Mitsuyama
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Gene Ther 13:348-55. 2006
    ..05) and suppressed the enhanced expression of collagen I, III, and IV, MCP-1 and PAI-1. These results provided the first evidence that in vivo blockade of cardiac c-Jun inhibits pathologic cardiac hypertrophy...