Yoshihiro Fujimura

Summary

Affiliation: Nara Medical University
Country: Japan

Publications

  1. ncbi request reprint Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome
    Yoshihiro Fujimura
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara City, Japan
    Int J Hematol 75:25-34. 2002
  2. doi request reprint Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Thromb Haemost 99:1019-29. 2008
  3. ncbi request reprint Potential role of ADAMTS13 in the progression of alcoholic hepatitis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, 634 8522, Japan
    Curr Drug Abuse Rev 1:188-96. 2008
  4. ncbi request reprint Increased von Willebrand factor over decreased ADAMTS13 activity may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis
    Tomomi Matsuyama
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Alcohol Clin Exp Res 31:S27-35. 2007
  5. doi request reprint Plasma ADAMTS13 activity parallels the APACHE II score, reflecting an early prognostic indicator for patients with severe acute pancreatitis
    Chie Morioka
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Scand J Gastroenterol 43:1387-96. 2008
  6. doi request reprint Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis: relationship to endotoxemia
    Masatoshi Ishikawa
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Alcohol Clin Exp Res 34:S25-33. 2010
  7. doi request reprint Proteolytic fragmentation and sugar chains of plasma ADAMTS13 purified by a conformation-dependent monoclonal antibody
    Hisahide Hiura
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan
    J Biochem 148:403-11. 2010
  8. doi request reprint Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation
    Manabu Horii
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, 634 8521, Japan
    Heart Vessels 23:301-7. 2008
  9. doi request reprint Ratio of von Willebrand factor propeptide to ADAMTS13 is associated with severity of sepsis
    Hidetada Fukushima
    Department of Emergency and Critical Care Medicine, Nara Medical University, Kashihara, Nara, Japan
    Shock 39:409-14. 2013
  10. doi request reprint Pregnancy-induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw-Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients
    Yoshihiro Fujimura
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara, Japan
    Br J Haematol 144:742-54. 2009

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome
    Yoshihiro Fujimura
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara City, Japan
    Int J Hematol 75:25-34. 2002
    ....
  2. doi request reprint Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Thromb Haemost 99:1019-29. 2008
    ..An imbalance between the decreased ADAMTS13:AC and its increased substrate may reflect the predisposing state for platelet thrombi formation in patients with advanced LC...
  3. ncbi request reprint Potential role of ADAMTS13 in the progression of alcoholic hepatitis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, 634 8522, Japan
    Curr Drug Abuse Rev 1:188-96. 2008
    ..The determination of ADAMTS13:AC and its substrate will give us new insights into the pathophysiology of acute alcoholic liver injury and help to elucidate additional therapeutic strategies for this disease...
  4. ncbi request reprint Increased von Willebrand factor over decreased ADAMTS13 activity may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis
    Tomomi Matsuyama
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Alcohol Clin Exp Res 31:S27-35. 2007
    ..We investigated the relationship of ADAMTS13 and von Willebrand factor antigen (VWF:Ag) with the clinical features of AH and SAH...
  5. doi request reprint Plasma ADAMTS13 activity parallels the APACHE II score, reflecting an early prognostic indicator for patients with severe acute pancreatitis
    Chie Morioka
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Scand J Gastroenterol 43:1387-96. 2008
    ..The purpose of the study was to investigate the potential role of ADAMTS13:AC in the severity of SAP...
  6. doi request reprint Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis: relationship to endotoxemia
    Masatoshi Ishikawa
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Alcohol Clin Exp Res 34:S25-33. 2010
    ..The aim of this study was to explore the potential mechanism to reduce the activity of plasma ADAMTS13...
  7. doi request reprint Proteolytic fragmentation and sugar chains of plasma ADAMTS13 purified by a conformation-dependent monoclonal antibody
    Hisahide Hiura
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan
    J Biochem 148:403-11. 2010
    ....
  8. doi request reprint Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation
    Manabu Horii
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, 634 8521, Japan
    Heart Vessels 23:301-7. 2008
    ....
  9. doi request reprint Ratio of von Willebrand factor propeptide to ADAMTS13 is associated with severity of sepsis
    Hidetada Fukushima
    Department of Emergency and Critical Care Medicine, Nara Medical University, Kashihara, Nara, Japan
    Shock 39:409-14. 2013
    ....
  10. doi request reprint Pregnancy-induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw-Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients
    Yoshihiro Fujimura
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara, Japan
    Br J Haematol 144:742-54. 2009
    ..Only the R193W mutation has been previously reported. These observations emphasize the importance of measuring ADAMTS13 activity in the evaluation of thrombocytopenia during childhood and pregnancy...
  11. ncbi request reprint ADAMTS13 activity decreases after hepatectomy, reflecting a postoperative liver dysfunction
    Eiji Okano
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Hepatogastroenterology 57:316-20. 2010
    ..This study evaluated changes of plasma ADAMTS13 activity and its clinical relevance in patients with hepatectomy...
  12. doi request reprint Pivotal role of ADAMTS13 function in liver diseases
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara Nara, 634 8522, Japan
    Int J Hematol 91:20-9. 2010
    ..These results promise to bring further understanding of the pathophysiology of liver diseases, and offer new insight for development of therapeutic strategies...
  13. ncbi request reprint ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score
    Hiroaki Takaya
    Third Department of Internal Medicine Departments of Blood Transfusion Medicine Community Health and Epidemiology, Nara Medical University, Kashihara, Nara, Japan
    Hepatol Res 42:459-72. 2012
    ..This activity may be a useful prognostic marker that is equal or superior to the CTP score and the MELD score to predict not only the short-term prognosis but also the long-term survival of the cirrhotic patients...
  14. ncbi request reprint Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions
    Yasuaki Shida
    Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan
    Blood 111:1295-8. 2008
    ..Our results identify an exquisitely specific regulatory mechanism that prevents arterial occlusion under high shear rate conditions during mural thrombogenesis...
  15. ncbi request reprint Quantitative Western blot analysis of plasma ADAMTS13 antigen in patients with Upshaw-Schulman syndrome
    Hiromichi Ishizashi
    Department of Health Science, Nara Medical University, Nara 634 8522, Japan
    Thromb Res 120:381-6. 2007
  16. doi request reprint ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant: implications for selection of plasma preparations for thrombotic thrombocytopenic purpura treatment
    Yuji Hori
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara, Japan The Chemo Sero Therapeutic Research Institute, Kikuchi, Kumamoto, Japan
    Transfusion 53:3192-202. 2013
    ..Treatment involves plasma exchange (PE). Both fresh-frozen plasma (FFP) and cryosupernatant (CSP) are used, but it remains to be determined which is more effective...
  17. ncbi request reprint Heterogeneous pathogenic processes of thrombotic microangiopathies in patients with connective tissue diseases
    Tomomi Matsuyama
    Department of Blood Transfusion Medicine, Nara Medical University, Shijyo cho 840, Kashihara City, Nara, 634 8522, Japan
    Thromb Haemost 102:371-8. 2009
    ..Classifying CTD-TMAs by ADAMTS13 activity may be useful in predicting the clinical course and therapeutic outcomes, as patients with moderately reduced activity are likely to have more prominent renal impairment and poor prognoses...
  18. ncbi request reprint Plasma levels of ADAMTS13 antigen determined with an enzyme immunoassay using a neutralizing monoclonal antibody parallel ADAMTS13 activity LevEls
    Hideo Yagi
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara, Japan
    Int J Hematol 85:403-7. 2007
    ..This ELISA may be useful for the rapid determination of ADAMTS13:AG. Further investigations of this antigen would be helpful in advancing the understanding of the pathogenesis of congenital and acquired TTP...
  19. ncbi request reprint Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome
    Masanori Matsumoto
    Department of Blood Transfusion Medicine, Nara Medical University, Shijyo cho 840, Kashihara City, Nara 634 8522, Japan
    Blood 103:1305-10. 2004
    ..Molecular models of the metalloprotease, fifth domain of thrombospondin 1 (Tsp1-5), and Tsp1-8 domains of ADAMTS13 suggest that the missense mutations could cause structural defects in the mutants...
  20. ncbi request reprint The Japanese experience with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
    Masanori Matsumoto
    Department of Blood Transfusion Medicine, Nara Medical University, Japan
    Semin Hematol 41:68-74. 2004
    ..The former patients were associated with "idiopathic" TTP, drugs, and pregnancy, and the latter patients with malignancy and stem cell transplantation. Patients with autoimmune disease-associated TTP fit into both groups...
  21. ncbi request reprint Reduced larger von Willebrand factor multimers at dawn in OSA plasmas reflect severity of apnoeic episodes
    Noriko Koyama
    Second Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Eur Respir J 40:657-64. 2012
    ..Severe OSA may contribute to an arterial pro-thrombotic state...
  22. doi request reprint Paradigm shift of childhood thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency
    Hideo Yagi
    Nara Medical University, Department of Blood Transfusion Medicine, Nara 634 8522, Japan
    Presse Med 41:e137-55. 2012
    ..This study focused on these 58 patients (41 USS and 17 acquired TTP) who were diagnosed with a severe deficiency in ADAMTS13 activity during childhood, causing a paradigm shift in our concept of TTP...
  23. ncbi request reprint Plasma ADAMTS13 activity may predict early adverse events in living donor liver transplantation: observations in 3 cases
    Saiho Ko
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Liver Transpl 12:859-69. 2006
    ..Our findings not only suggest a novel mechanism for thrombocytopenia, but also provide a useful tool for diagnosis of graft dysfunction in the early stage after transplantation...
  24. pmc Determination of ADAMTS13 and Its Clinical Significance for ADAMTS13 Supplementation Therapy to Improve the Survival of Patients with Decompensated Liver Cirrhosis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Int J Hepatol 2011:759047. 2011
    ..Such treatments may improve the survival of patients with decompensated LC...
  25. ncbi request reprint Registry of 919 patients with thrombotic microangiopathies across Japan: database of Nara Medical University during 1998-2008
    Yoshihiro Fujimura
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan
    Intern Med 49:7-15. 2010
    ..Severe deficiency of plasma ADAMTS13 activity (ADAMTS13: AC) is more specific for TTP, but not for HUS. Since 1998, our laboratory has functioned as a nationwide referral center for TMAs by analyzing ADAMTS13...
  26. ncbi request reprint Novel monoclonal antibody-based enzyme immunoassay for determining plasma levels of ADAMTS13 activity
    Seiji Kato
    Department of Blood Transfusion Medicine, Nara Medical University, Nara, Japan
    Transfusion 46:1444-52. 2006
    ..The determination of plasma levels of ADAMTS13 activity is a prerequisite for a differential diagnosis of thrombotic microangiopathies. Here, a unique and highly sensitive enzyme immunoassay (EIA) of ADAMTS13 activity is described...
  27. pmc Acquired idiopathic ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in a population from Japan
    Masanori Matsumoto
    Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan
    PLoS ONE 7:e33029. 2012
    ..Additional studies exploring these findings are needed...
  28. ncbi request reprint Decreased activity of plasma ADAMTS13 may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Alcohol Clin Exp Res 29:264S-71S. 2005
    ..The aim of this study was to explore the potential role of ADAMTS13 on the development of liver disturbance and multiorgan failure in AH...
  29. ncbi request reprint Mural thrombus generation in type 2A and 2B von Willebrand disease under flow conditions
    Mitsuhiko Sugimoto
    Department of Pediatrics, Nara Medical University, Kashihara, Japan
    Blood 101:915-20. 2003
    ....
  30. doi request reprint Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis
    Yasuhiro Takemoto
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Arterioscler Thromb Vasc Biol 29:857-62. 2009
    ..We tested the hypothesis that local delivery of human placental E-NTPDase (pE-NTPDase) gene into injured arteries via gene-eluting stent could prevent subacute in-stent thrombosis...
  31. ncbi request reprint Localization of ADAMTS13 to the stellate cells of human liver
    Masahito Uemura
    Third Department of Internal Medicine, Department of Anatomy, Nara Medical University, 840 Shijo Cho, Kashihara City, Nara, 634 8522, Japan
    Blood 106:922-4. 2005
    ..These results suggest that HSCs may be major cells producing ADAMTS13 in human liver...
  32. ncbi request reprint [Shear stress-induced platelet aggregation in children with minimal change nephrotic syndrome]
    Ken Takagawa
    Department of Pediatrics, Nara Medical University, Japan
    Nihon Jinzo Gakkai Shi 44:380-8. 2002
    ..The enhanced SIPA may play an important thrombogenic role in the acute phase of childhood MCNS...
  33. ncbi request reprint Anticoagulant activity of M-LAO, L-amino acid oxidase purified from Agkistrodon halys blomhoffii, through selective inhibition of factor IX
    Yoshihiko Sakurai
    Department of Pediatrics, Nara Medical University, 840 Shijo Cho, Nara Kashihara 634 8522, Japan
    Biochim Biophys Acta 1649:51-7. 2003
    ..These results indicate that M-LAO has an anticoagulant activity that impairs the intrinsic clotting by inhibiting factor IX...
  34. ncbi request reprint [vWF-cleaving protease/ADAMTS 13]
    Masanori Matsumoto
    Rinsho Ketsueki 44:159-67. 2003
  35. ncbi request reprint VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13
    Koichi Kokame
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Blood 103:607-12. 2004
    ..Thus, VWF73 will be a useful seed to develop a new rapid assay to determine ADAMTS-13 activity...
  36. ncbi request reprint Successful treatment of a young infant who developed high-titer inhibitors against VWF-cleaving protease (ADAMTS-13): important discrimination from Upshaw-Schulman syndrome
    Akira Ashida
    Department of Pediatrics, Osaka Medical College, Osaka, Japan
    Am J Hematol 71:318-22. 2002
    ..From our experience, it was suggested that we should recognize the possibility of the patient with acquired TTP in infancy and the importance of plasma exchange therapy for management of its clinical symptoms...
  37. pmc Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity
    Koichi Kokame
    Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Proc Natl Acad Sci U S A 99:11902-7. 2002
    ..We report on a single-nucleotide polymorphism associated with alterations in VWF-CP activity; it will be important to assess this single-nucleotide polymorphism as a risk factor for thrombotic disorders...
  38. ncbi request reprint [Thrombosis and ADAMTS13 exclusively produced in the liver]
    Yoshihiro Fujimura
    Rinsho Ketsueki 49:1420-33. 2008
  39. ncbi request reprint Predicting response to plasma exchange in patients with thrombotic thrombocytopenic purpura with measurement of vWF-cleaving protease activity
    Yoshitaka Mori
    Mie Red Cross Blood Center, Tsu City, Japan
    Transfusion 42:572-80. 2002
    ..Although the survival of patients with TTP has been dramatically improved with plasma exchange (PE), there are still many patients who are refractory to PE and immunosuppressive therapy...
  40. ncbi request reprint [TTP/HUS and VWF/ADAMTS-13]
    Yoshihiro Fujimura
    Rinsho Ketsueki 44:1144-53. 2003
  41. ncbi request reprint Binding site on human von Willebrand factor of bitiscetin, a snake venom-derived platelet aggregation inducer
    Taei Matsui
    Division of Biomedical Polymer Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Biochemistry 41:7939-46. 2002
    ..Bitiscetin and botrocetin might modulate VWF by binding to the homologous region of the A1 domain to induce a conformational change leading to an increased accessibility to platelet GPIb...
  42. ncbi request reprint Von Willebrand factor--cleaving protease activity in thrombotic microangiopathy after living donor liver transplantation: a case report
    Yuichi Nakazawa
    First Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Liver Transpl 9:1328-33. 2003
    ..Clinical findings suggest that TMA was tacrolimus-induced...
  43. ncbi request reprint ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage
    Kenji Soejima
    First Research Department, The Chemo Sero Therapeutic Research Institute, Kawabe, Kyokushi, Kikuchi, Kumamoto 869 1298, Japan
    Blood 102:3232-7. 2003
    ..The major epitopes of these antibodies were found to reside within the cysteine-rich/spacer domains. These results suggest that the ADAMTS-13 cysteine-rich/spacer domains are essential for VWF-CP activity...
  44. ncbi request reprint [Changes of ADAMTS13 activity and endothelial cell markers in TMA cases]
    Yoshitaka Mori
    Mie Red Cross Blood Center, Japan
    Rinsho Ketsueki 45:378-82. 2004
    ..These data suggest that the etiology in these patients may be systemic vascular endothelial cell damage...
  45. ncbi request reprint Adenovirus-mediated transfer of human placental ectonucleoside triphosphate diphosphohydrolase to vascular smooth muscle cells suppresses platelet aggregation in vitro and arterial thrombus formation in vivo
    Eiji Furukoji
    Department of Radiology, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Circulation 111:808-15. 2005
    ..The present study examined whether these isoforms suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to vascular smooth muscle cells (SMCs)...
  46. ncbi request reprint Development of ADAMTS13 inhibitor in a patient with hepatitis C virus-related liver cirrhosis causes thrombotic thrombocytopenic purpura
    Masato Yagita
    J Hepatol 42:420-1. 2005
  47. ncbi request reprint [Progress on TTP/HUS diagnosis with analysis of VWF-cleaving protease activation]
    Yoshihiro Fujimura
    Nihon Naika Gakkai Zasshi 93:451-9. 2004
  48. ncbi request reprint Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure
    Yugo Shibagaki
    Department of Nephrology and Endocrinology, Graduate School of Medicine, University of Tokyo, Japan
    Nephrol Dial Transplant 21:1289-92. 2006
    ..However, the symptoms significantly vary in each individual and thus clinicians often overlook this diagnosis...
  49. ncbi request reprint [Thrombotic microangiopathy]
    Yoshihiro Fujimura
    Rinsho Ketsueki 47:734-47. 2006
  50. ncbi request reprint Identification of novel mutations in ADAMTS13 in an adult patient with congenital thrombotic thrombocytopenic purpura
    Toshihiro Uchida
    New Product Laboratories II, Daiichi Pharmaceutical, Tokyo, Japan
    Blood 104:2081-3. 2004
    ..In vitro expression studies revealed that the A250V mutation markedly reduced ADAMTS13 activity and the intron 3 G-->A mutation caused abnormal mRNA synthesis...
  51. ncbi request reprint Rituximab provided long-term remission in a patient with refractory relapsing thrombotic thrombocytopenic purpura
    Satoru Kosugi
    Department of Internal Medicine, Toyonaka Municipal Hospital, 1 14 1, Shibahara cho, Toyonaka, Osaka, 560 8565, Japan
    Int J Hematol 81:433-6. 2005
    ..Rituximab should be considered as a therapeutic alternative for refractory TTP...
  52. ncbi request reprint [Brain nerve symptoms due to thrombotic microangiopathy]
    Hideo Yagi
    Nihon Naika Gakkai Zasshi 96:353-62. 2007
  53. ncbi request reprint [Thrombotic microangiopathy]
    Yoshihiro Fujimura
    Department of Blood Transfusion Medicie, Nara Medical University
    Rinsho Shinkeigaku 46:902-5. 2006
    ..Case 2 was unable to assay ADAMTS13 activity, but later the autopsy revealed the presence of multiple hyaline membrane thrombosis in many organs, together with a lack of demyelinating lesions, solely confirming a diagnosis of TMA...
  54. ncbi request reprint [Von Willebrand factor-cleaving protease activity in patients of collagen disease with antiphospholipid antibodies]
    Satoshi Yamazaki
    Department of Clinical Laboratory, St Marianna University School of Medicine Hospital, Kawasaki 216 8511
    Rinsho Byori 50:301-7. 2002
    ..These results suggest that decreased activity of VWF-CPase, partly due to IgG type inhibitor to the enzyme activity may be an additional risk factor for arterial thrombosis in collagen disease patients with antiphospholipid antibodies...
  55. ncbi request reprint [Case of thrombotic thrombocytopenic purpura associated with clopidogrel]
    Toshihiro Fukusako
    Department of Neurology, Yamaguchi Grand Medical Center
    Rinsho Shinkeigaku 47:635-8. 2007
    ..Because it is assumed that the mechanism of clopidogrel induced TTP differs from that of ticlopidine, we should establish firm treatment urgently...
  56. ncbi request reprint Von Willebrand factor-cleaving protease activity remains at the intermediate level in thrombotic thrombocytopenic purpura
    Takeshi Sugimoto
    Hematology Oncology Division, Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan
    Acta Haematol 113:198-203. 2005
    ..Further studies to determine the effects of interferon-alpha on endothelial cells in chronic myelogenous leukemia patients are needed...
  57. pmc Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project
    Charles L Bennett
    VA Center for Management of Complex Chronic Care at Jesse Brown VA Medical Center, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Coll Cardiol 50:1138-43. 2007
    ..We sought to describe clinical and laboratory findings for a large cohort of patients with thienopyridine-associated thrombotic thrombocytopenic purpura (TTP)...
  58. ncbi request reprint [Refractory thrombotic thrombocytopenic purpura successfully treated with a combination of rituximab and vincristine]
    Hitomi Kaneko
    Third Department of Internal Medicine, Osaka Red Cross Hospital
    Rinsho Ketsueki 48:144-7. 2007
    ..Recovery of the plasma ADAMTS13 activity was clearly correlated with the decrease or disappearance of the inhibitor activity. Combination of rituximab and vincristine therapy would appear to be very effective against refractory TTP...
  59. ncbi request reprint Decreased ADAMTS13 activity in plasma from patients with thrombotic thrombocytopenic purpura
    Toshihiko Kobayashi
    Second Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Japan
    Thromb Res 119:447-52. 2007
    ..These findings suggest that the ADAMTS13 FRET assay correlates well with the ADAMTS13 multimer method and it is therefore useful for making a diagnosis of TTP...
  60. ncbi request reprint Thrombotic thrombocytopenic purpura associated with pegylated-interferon alpha-2a by an ADAMTS13 inhibitor in a patient with chronic hepatitis C
    Kiyoshi Kitano
    Department of Internal Medicine, Matsumoto National Hospital, Matsumoto, Japan
    Haematologica 91:ECR34. 2006
    ..Serial determination of ADAMTS13 activity and its inhibitor may provide useful information for the diagnosis and treatment of IFN-associated TTP, as well as its pathogenesis...
  61. ncbi request reprint Intensive plasma IgG removal therapy for severe thrombotic thrombocytopenic purpura
    Saori Yasuzawa Amano
    Int J Hematol 76:474-6. 2002
  62. ncbi request reprint Intravenous gamma globulin for thrombotic microangiopathy of unknown etiology
    Shuichi Ito
    Children s Medical Center, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Pediatr Nephrol 22:301-5. 2007
    ..He has not suffered a relapse of TMA or an allograft rejection for 4 years. IVIG might be an option for some patients with TMA of unknown etiology refractory to conventional treatment...
  63. ncbi request reprint Successful treatment of primitive neuroectodermal tumor-associated microangiopathy with multiple bone metastases
    Toru Morishita
    Department of Orthopedic Surgery, National Hospital Organization Nara Medical Center, Nara, Japan
    Jpn J Clin Oncol 37:66-9. 2007
    ..This strategy should be confirmed in further cases...
  64. ncbi request reprint [Rituximab provided long-term remission in a patient with severe thrombotic thrombocytopenic purpura refractory to plasma exchange]
    Hyunsoo Hong
    Department of Hematology, Seichokai Fuchu Hospital
    Rinsho Ketsueki 47:1528-32. 2006
    ..The patient has remained in complete remission for more than 1 year. Our data suggest that rituximab may be the optimal immunosuppressive therapy for refractory thrombotic thrombocytopenic purpura caused by an anti-ADAMTS 13 inhibitor...