Kazuhiko Nakayama

Summary

Country: Japan

Publications

  1. ncbi request reprint Possible alteration of tryptophan metabolism following repeated administration of sertraline in the rat brain
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Brain Res Bull 59:293-7. 2003
  2. ncbi request reprint [Mechanism of action of new generation antidepressants under development in Japan: focusing on dopamine neurotransmission]
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:99-108. 2009
  3. ncbi request reprint Effect of paroxetine on extracellular serotonin and dopamine levels in the prefrontal cortex
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo 105 8461, Japan
    Naunyn Schmiedebergs Arch Pharmacol 365:102-5. 2002
  4. ncbi request reprint Diurnal rhythm in extracellular levels of 5-hydroxyindoleacetic acid in the medial prefrontal cortex of freely moving rats: an in vivo microdialysis study
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, Nishishinbashi 3 19 18, Minato ku, Tokyo 105 8471, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1383-8. 2002
  5. ncbi request reprint Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Brain Res Bull 63:237-41. 2004
  6. doi request reprint Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease
    Nobuyuki Kobayashi
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 34:190-7. 2012
  7. doi request reprint Association between executive dysfunction and hippocampal volume in Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Int Psychogeriatr 23:764-71. 2011
  8. ncbi request reprint Genetic association between APOA1 and APOD polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Neural Transm 120:1599-603. 2013
  9. doi request reprint Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 33:266-72. 2012
  10. doi request reprint Mirtazapine improves visual hallucinations in Parkinson's disease: a case report
    Kenji Tagai
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Psychogeriatrics 13:103-7. 2013

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Possible alteration of tryptophan metabolism following repeated administration of sertraline in the rat brain
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Brain Res Bull 59:293-7. 2003
    ..In conclusion, the data show that the increase in tryptophan levels and the decrease in 5-HT turnover in rat brain are attenuated by repeated treatment of sertraline...
  2. ncbi request reprint [Mechanism of action of new generation antidepressants under development in Japan: focusing on dopamine neurotransmission]
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:99-108. 2009
    ..Clinically, mirtazapine shows an earlier onset of action and a sedative effect. Bupropion is a DA and NA reuptake inhibitor, and is considered useful to activate DA neurons...
  3. ncbi request reprint Effect of paroxetine on extracellular serotonin and dopamine levels in the prefrontal cortex
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo 105 8461, Japan
    Naunyn Schmiedebergs Arch Pharmacol 365:102-5. 2002
    ..These results suggest that the increase in extracellular dopamine concentration in the mPFC elicited by paroxetine is the result of stimulation of 5-HT(3) receptors by the extracellular accumulation of 5-HT in the mPFC...
  4. ncbi request reprint Diurnal rhythm in extracellular levels of 5-hydroxyindoleacetic acid in the medial prefrontal cortex of freely moving rats: an in vivo microdialysis study
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, Nishishinbashi 3 19 18, Minato ku, Tokyo 105 8471, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1383-8. 2002
    ....
  5. ncbi request reprint Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Brain Res Bull 63:237-41. 2004
    ..These results indicate that mirtazapine induces the enhancement of the output of cortical dopamine mediated via blockade of alpha(2)-adrenergic receptors and facilitation of post-synaptic 5-HT(1A) function...
  6. doi request reprint Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease
    Nobuyuki Kobayashi
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 34:190-7. 2012
    ....
  7. doi request reprint Association between executive dysfunction and hippocampal volume in Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Int Psychogeriatr 23:764-71. 2011
    ..The aim of the present study was to evaluate how the hippocampal volume influences executive function as a non-memory cognitive function...
  8. ncbi request reprint Genetic association between APOA1 and APOD polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Neural Transm 120:1599-603. 2013
    ..Our results suggest that the variation of the APOD gene modifies the risk for AD. Further association studies for APOD 3' UTR polymorphisms with other ethnic groups would be needed. ..
  9. doi request reprint Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 33:266-72. 2012
    ....
  10. doi request reprint Mirtazapine improves visual hallucinations in Parkinson's disease: a case report
    Kenji Tagai
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Psychogeriatrics 13:103-7. 2013
    ..Mirtazapine improved the patient's refractory psychotic symptoms, especially her visual hallucinations, without worsening her motor symptoms. ..
  11. ncbi request reprint Association between nerve growth factor gene polymorphism and executive dysfunction in Japanese patients with early-stage Alzheimer's disease and amnestic mild cognitive impairment
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 32:379-86. 2011
    ....
  12. doi request reprint Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan
    Psychiatry Clin Neurosci 63:449-54. 2009
    ....
  13. doi request reprint Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Biochem Biophys Res Commun 430:907-11. 2013
    ....
  14. doi request reprint Differentiation between amnestic-mild cognitive impairment and early-stage Alzheimer's disease using the Frontal Assessment Battery test
    Ayumi Yamao
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Psychogeriatrics 11:235-41. 2011
    ..The aim of the present cross-sectional study is to evaluate executive dysfunction using the Frontal Assessment Battery (FAB) screening test in two groups and to investigate the interaction with other cognitive impairments...
  15. doi request reprint Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation
    Michiaki Morita
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 65:246-53. 2011
    ..The purpose of this study was to elucidate the mechanism underlying the clinical efficacy of mirtazapine-perospirone combination therapy for treatment-resistant depression in a rat model...
  16. doi request reprint Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychogeriatrics 11:141-9. 2011
    ....
  17. doi request reprint Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo, 105 8471, Japan
    J Neural Transm 121:433-41. 2014
    ..The plasma BDNF level was robustly correlated with aggressiveness, implying that the plasma BDNF level might be useful as a behavioral state marker in patients with AD or A-MCI. ..
  18. doi request reprint Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Int Psychogeriatr 22:463-9. 2010
    ....
  19. doi request reprint Facilitation of intracranial self-stimulation behavior in rats by environmental stimuli associated with nicotine
    Michio Itasaka
    Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8510, Japan Department of Psychology, Graduate School of Humanities, Senshu University, 2 1 1, Higashi mita, Tama ku, Kawasaki shi, Kanagawa, 214 8580, Japan
    Physiol Behav 107:277-82. 2012
    ..The present results demonstrate that nicotine-conditioned contextual stimuli may affect the mesolimbic dopamine system through ICSS threshold lowering effect...
  20. ncbi request reprint [Psychophysiological evaluations of clinical efficacy in outpatients: Morita therapy for psychophysiological insomnia]
    Wataru Yamadera
    Department of Psychiatry, Jikei University School of Medicine
    Seishin Shinkeigaku Zasshi 107:341-51. 2005
    ..This finding suggested that Morita therapy on outpatients with PPI was effective in helping subjects accept their insomnia and lied a constructive life...
  21. ncbi request reprint Clonazepam for chemotherapy-induced nausea and vomiting (CINV)
    Minako Koga
    Department of Psychiatry, Machida Municipal Hospital, Machida shi, Tokyo, 194 0023, Japan
    Anticancer Res 28:2433-6. 2008
    ..A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines...
  22. doi request reprint A case in which mirtazapine reduced auditory hallucinations in a patient with Parkinson disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Int Psychogeriatr 25:1199-201. 2013
    ..The present case suggests the effectiveness of MRZ for the treatment of refractory AHs in patients with PD...
  23. doi request reprint Managing abnormal eating behaviours in frontotemporal lobar degeneration patients with topiramate
    Shunichiro Shinagawa
    Department of Psychiatry, Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Psychogeriatrics 13:58-61. 2013
    ..Topiramate was effective, especially for compulsive eating, in cases with distinct lobar atrophy, but not for all abnormal eating behaviours...
  24. pmc Age-Related Association between Apolipoprotein E ε4 and Cognitive Function in Japanese Patients with Alzheimer's Disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Tokyo, Japan Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 3:66-73. 2013
    ..In the present study, we investigated whether apolipoprotein E (APOE) polymorphisms influenced the cognitive function of Japanese patients with Alzheimer's disease (AD) at certain ages...
  25. ncbi request reprint Anorexia nervosa with chronic episodes for more than 30 years in a patient with a comorbid schizotypal personality disorder
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 61:434-6. 2007
    ..She was treated with low-dose antipsychotics, and her impulsive behavior improved. The patient's SPD was considered to have had a psychopathological contribution to her chronic episodes of anorexia nervosa...
  26. ncbi request reprint Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan
    Psychiatry Clin Neurosci 61:695-7. 2007
    ..The efficacy of CBZ treatment in this patient suggests a method for controlling benzodiazepine-resistant impulsive aggression...
  27. pmc Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population
    Satoshi Kawamura
    Department of Psychiatry, Tokyo Jikei University School of Medicine, Tokyo, Japan
    Neuropsychiatr Dis Treat 7:655-62. 2011
    ..5273). In conclusion, the predisposition for BPD with MDD is associated with that for PCOS, in the female Japanese population. An elevated serum IL-6 level is considered to be a possible biomarker of BPD with MDD...
  28. doi request reprint Clinical efficacy of individual cognitive behavior therapy for psychophysiological insomnia in 20 outpatients
    Miki Sato
    Department of Psychiatry, Jikei University School of Medicine, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 64:187-95. 2010
    ..9 years, and the mean duration of insomnia morbidity was 8.9 years. Each received individual combined CBT treatments consisting of stimulus control, sleep reduction, cognitive therapy and sleep hygiene education over a period of 1 month...
  29. pmc Longitudinal Changes in the Government-Certified Index Stage and Requisite Costs for Long-Term Care Insurance System among the Community-Dwelling Demented Elderly in Japan
    Shunichiro Shinagawa
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Int J Alzheimers Dis 2013:164919. 2013
    ..VaD subjects required higher costs than AD subjects in the total certified period and in GCI stage 5. Conclusion. Our results indicate that causes of dementia can have an impact on the requisite costs for the LTC insurance...
  30. doi request reprint A comparison of family care infrastructure for demented elderly in inner cities and regional areas in Japan
    Shunichiro Shinagawa
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychogeriatrics 12:159-64. 2012
    ..We aimed to compare the family caregiving infrastructure of demented elderly visiting a memory clinic...
  31. pmc Decreases in brain reward function reflect nicotine- and methamphetamine-withdrawal aversion in rats
    Hisatsugu Miyata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Curr Neuropharmacol 9:63-7. 2011
    ....
  32. doi request reprint Usefulness of pharmacist-assisted screening and psychiatric referral program for outpatients with cancer undergoing chemotherapy
    Tatsuhiko Ito
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan
    Psychooncology 20:647-54. 2011
    ..We introduced a clinical screening program utilizing the Distress and Impact Thermometer (DIT) to identify MDD and AD in cancer outpatients receiving chemotherapy. This study assessed the usefulness of the screening program...
  33. ncbi request reprint [Case of prolonged recovery from serotonin syndrome caused by paroxetine]
    Yusuke Ochiai
    Department of Psychiatry, Jikei University School of Medicine
    Seishin Shinkeigaku Zasshi 105:1532-8. 2003
    ..Therefore, when serotonin syndrome is suspected, prompt discontinuation of the suspected causative medication, followed by close monitoring of the pharmacokinetics is warranted...
  34. ncbi request reprint [Psychiatry and sleep disorders--delirium]
    Hiroshi Ito
    Seishin Shinkeigaku Zasshi 108:1217-21. 2006
  35. ncbi request reprint Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652
    Tetsuya Ichimiya
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 51:715-22. 2002
    ..The aim of this study was to examine whether 5-HTT binding was altered in patients with mood disorders using positron emission tomography (PET)...
  36. ncbi request reprint Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia
    Tetsuya Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba shi, 263 8555 Japan
    Arch Gen Psychiatry 59:25-30. 2002
    ..On the other hand, a number of studies have reported abnormalities in the cerebral cortex of schizophrenia. The aim of this study was to examine the extrastriatal D2 receptors of patients with schizophrenia...