Yusaku Nakabeppu

Summary

Country: Japan

Publications

  1. ncbi MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    DNA Repair (Amst) 5:761-72. 2006
  2. pmc 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair
    Zijing Sheng
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Clin Invest 122:4344-61. 2012
  3. ncbi An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress
    Daisuke Yoshimura
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 278:37965-73. 2003
  4. ncbi Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Ann N Y Acad Sci 1011:101-11. 2004
  5. ncbi The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal
    Yasunari Sakai
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Mol Med (Berl) 84:660-70. 2006
  6. ncbi The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Free Radic Res 38:423-9. 2004
  7. pmc Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts
    Akimasa Ichinoe
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Fukuoka
    Nucleic Acids Res 32:477-87. 2004
  8. doi Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage
    Sugako Oka
    Division of Neurofunctional Genomics, Department of Immunology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Methods Mol Biol 554:251-64. 2009
  9. ncbi Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Biol Chem 387:373-9. 2006
  10. pmc Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs
    Sugako Oka
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    EMBO J 27:421-32. 2008

Detail Information

Publications89

  1. ncbi MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    DNA Repair (Amst) 5:761-72. 2006
    ....
  2. pmc 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair
    Zijing Sheng
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Clin Invest 122:4344-61. 2012
    ....
  3. ncbi An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress
    Daisuke Yoshimura
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 278:37965-73. 2003
    ..Human MTH1 thus protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP, and these alterations may be partly attributed to a mitochondrial dysfunction...
  4. ncbi Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Ann N Y Acad Sci 1011:101-11. 2004
    ..The increased occurrence of lung tumor in OGG1-deficient mice was completely abolished by the concomitant disruption of the Mth1 gene...
  5. ncbi The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal
    Yasunari Sakai
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Mol Med (Berl) 84:660-70. 2006
    ..The cellular fractionation revealed that MTH1a(Met83) was localized in the mitochondria to the same extent as was MTH1d(Val83). However, the mitochondrial translocation of MTH1d(Met83) was less efficient than that of MTH1d(Val83)...
  6. ncbi The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Free Radic Res 38:423-9. 2004
    ..Furthermore, these defense mechanisms also likely play an important role in neuroprotection...
  7. pmc Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts
    Akimasa Ichinoe
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Fukuoka
    Nucleic Acids Res 32:477-87. 2004
    ..Recombinant MUTYHalpha possessed DNA glycosylase activities to excise adenine opposite 8-oxoguanine and guanine but not AP lyase activity...
  8. doi Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage
    Sugako Oka
    Division of Neurofunctional Genomics, Department of Immunology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Methods Mol Biol 554:251-64. 2009
    ..Knockdown of MUTYH which excises adenine opposite 8-oxoG in DNA prevents degradation of mitochondrial DNA and activation of calpain, thus suppressing the cell death induced by menadione...
  9. ncbi Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Biol Chem 387:373-9. 2006
    ....
  10. pmc Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs
    Sugako Oka
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    EMBO J 27:421-32. 2008
    ..SSBs in nuclear DNA activated PARP, whereas those in mitochondrial DNA caused their depletion, thereby initiating the two distinct pathways of cell death...
  11. pmc NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
    Teruaki Iyama
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    Nucleic Acids Res 38:4834-43. 2010
    ..We thus concluded that NUDT16 is a (deoxy)inosine diphosphatase that may function mainly in the nucleus to protect cells from deleterious effects of (d)ITP...
  12. ncbi Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death
    Junji Ichikawa
    Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812 8582, Japan
    DNA Repair (Amst) 7:418-30. 2008
    ..We thus concluded that exposure of cells to sodium nitroprusside causes oxidation of mitochondrial deoxynucleotide pools, and that buildup of oxidized bases in mitochondrial DNA initiates cell death...
  13. doi Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus
    Yukihiko Dan
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    DNA Repair (Amst) 7:1437-54. 2008
    ..The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair...
  14. pmc MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain
    Yohei Tominaga
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Nucleic Acids Res 32:3198-211. 2004
    ..The G365D mutant failed to prevent OGG1 from excising 8-oxoG opposite the generated AP site, thus indicating that the protection of its own product by mMUTYH is an intrinsic function which depends on the C-terminal domain of mMUTYH...
  15. ncbi Mutator phenotype of MUTYH-null mouse embryonic stem cells
    Seiki Hirano
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Fukuoka, 812 8582, Japan
    J Biol Chem 278:38121-4. 2003
    ..The germ-line mutation (G382D) of the human MUTYH gene is therefore likely to be responsible for the occurrence of a mutator phenotype in these patients...
  16. doi Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mutat Res 703:51-8. 2010
    ....
  17. ncbi Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis
    Teruhisa Tsuzuki
    Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 98:465-70. 2007
    ..Here we discuss our recent investigation of mutagenesis and carcinogenesis in these mutant mice...
  18. pmc fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior
    Noriko Yutsudo
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Neuropsychopharmacology 38:895-906. 2013
    ....
  19. ncbi MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis
    Katsumi Sakamoto
    Departments of Medical Biophysics and Radiation Biology, Clinical Radiology, and Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi Higashi ku, Fukuoka 812 8582, Japan
    Cancer Res 67:6599-604. 2007
    ....
  20. ncbi In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis
    Ping Xu
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University and CREST, Japan Science and Technology Corp, Fukuoka 812 8582, Japan
    J Biol Chem 278:48422-33. 2003
    ..5 mouse embryo, whereas Wnt1 and Pax2 were coexpressed with JSAP1 at the midbrain-hindbrain junction in E12.5 mouse embryo, thus suggesting that JSAP1 is required for early embryonic neurogenesis...
  21. ncbi Oxidative damage in nucleic acids and Parkinson's disease
    Yusaku Nakabeppu
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Neurosci Res 85:919-34. 2007
    ....
  22. pmc A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome
    Mizuki Ohno
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Genome Res 16:567-75. 2006
    ..Our findings suggest that 8-oxoG is one of the main causes of frequent recombinations and SNPs in the human genome, which largely contribute to the genomic diversity in human beings...
  23. ncbi Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine
    Mari Nonaka
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    FEBS J 276:1654-66. 2009
    ..Moreover, RS21-C6 may also prevent inappropriate DNA methylation, DNA replication blocking or mutagenesis by hydrolyzing modified dCTP...
  24. ncbi Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice
    Yasuhito Ide
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Blood 104:4097-103. 2004
    ....
  25. pmc A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA
    Yasuhiro Ushijima
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Nucleic Acids Res 33:672-82. 2005
    ....
  26. ncbi Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis
    Hitoshi Kikuchi
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Acta Neuropathol 103:408-14. 2002
    ..Our results indicate that the oxidative damage accumulates in the mitochondria of motor neurons in ALS, and that hOGG1 does not repair the damage efficiently, which may lead to a loss of motor neurons in ALS...
  27. pmc NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals
    Nona Abolhassani
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812 8582, Japan
    Nucleic Acids Res 38:2891-903. 2010
    ..We thus conclude that NUDT16 and ITPA play a dual protective role for eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals...
  28. doi ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells
    Kunihiko Sakumi
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mutat Res 703:43-50. 2010
    ..The biological significance of ITP and dITP in the nucleotide pool remains to be elucidated...
  29. doi Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method
    Mizuki Ohno
    Division of Neurofunctional Genomics, Department of Immunology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Methods Mol Biol 554:199-212. 2009
    ..These results indicate that OGG1 is a major enzyme for excision repair of 8-oxoG in mitochondrial DNA in mouse cells, and that our method described here is appropriate to study 8-oxoG dynamics in mitochondrial DNA...
  30. doi MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration
    Yusuke Murakami
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Pathol 181:1378-86. 2012
    ....
  31. ncbi Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein
    Kumiko Torisu
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582
    J Biochem 138:763-72. 2005
    ..We found candidate sequences for NEIL3 orthologues in a DNA database from dog and zebrafish in addition to human and mouse, but not invertebrates. NEIL3 may function exclusively in vertebrates, such as mammals...
  32. ncbi MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity
    Kosuke Kajitani
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 26:1688-98. 2006
    ....
  33. doi Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis
    Masaki Gushima
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Pathol 219:77-86. 2009
    ..In conclusion, inflamed mucosa of UC is exposed to oxidative damage. An increase in cytoplasmic MUTYH, rather than its mutation, may contribute to the promotion of carcinogenesis in UC...
  34. doi Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues
    Eiji Iwama
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    J Mol Neurosci 44:103-14. 2011
    ..The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems...
  35. ncbi Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption
    Kunihiko Sakumi
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University and CREST, JST, Fukuoka 812 8582, Japan
    Cancer Res 63:902-5. 2003
    ..This observation suggests that Mth1 gene disruption resulted in a suppression of the tumorigenesis caused by an Ogg1 deficiency...
  36. pmc Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts
    Yoshinori N Ohnishi
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Mol Biol Cell 19:4717-29. 2008
    ..We thus concluded that FosB and DeltaFosB/Delta2DeltaFosB use this pathway to antagonistically regulate cell matrix adhesion...
  37. ncbi Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension
    Toshio Ohtsubo
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    DNA Repair (Amst) 6:760-9. 2007
    ..We thus suggest that MTH1 may protect EC in the aorta from the oxidative damage increased by hypertension...
  38. pmc Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia
    Hiroko Nomaru
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Glia 62:1284-98. 2014
    ..These findings demonstrate that, under excitotoxicity, Fosb products contribute to a neuroinflammatory response in the hippocampus through regulation of microglial C5ar1 and C5ar2 expression. GLIA 2014;62:1284-1298. ..
  39. ncbi Defense mechanism to oxidative DNA damage in glial cells
    Takashi Iida
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 24:125-30. 2004
    ....
  40. doi A comprehensive screening system for damaged nucleotide-binding proteins
    Daisuke Tsuchimoto
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mutat Res 703:37-42. 2010
    ..In conclusion, the results of these studies show that our screening system is applicable in studying the health effects of damaged nucleotides and cellular sanitizing systems for nucleotide pools...
  41. pmc FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB
    Yoshinori N Ohnishi
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 70:487-95. 2011
    ..However, the functional differences of these two fosB products remain unclear...
  42. pmc Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    Kyota Fujita
    Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 4:e7247. 2009
    ..Thus, drinking H(2)-containing water may be useful in daily life to prevent or minimize the risk of life style-related oxidative stress and neurodegeneration...
  43. pmc Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice
    Akio Matsumoto
    1 Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba 2 Division of Molecular Design, Medical Institute of Bioregulation, Kyushu University, Fukuoka 3 Research Center for Nucleotide Pool, Kyushu University, Fukuoka, Japan 4
    Sci Rep 3:3273. 2013
    ..Our findings point to potential, novel strategies for ameliorating pathophysiology in which a protective effect of H₂ supplementation has been demonstrated...
  44. ncbi Regulation of the neuronal fate by DeltaFosB and its downstream target, galectin-1
    Tomofumi Miura
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Curr Drug Targets 6:437-44. 2005
    ..We herein propose that DeltaFosB together with galectin-1, may therefore mediate neuroprotection and neurogenesis in response to brain damage...
  45. ncbi Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C
    Kotaro Shibahara
    Department of Medical Biochemistry, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 95:348-53. 2004
    ..YB-1 may have the capacity to exert a protective role against cytotoxic effects of DNA damaging agents, and may be involved in certain aspects of drug resistance...
  46. doi Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes
    Noboru Murakami
    From the Department of Medicine and Clinical Science, Graduate School of Medical Sciences N M, T O, Y K, K G, H N, Y H, K M, T K, Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation Y N, and Research Center for Nucleotide Pool Y N, Kyushu University, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 34:44-51. 2014
    ..The aim of this study was to examine the role of XOR in adipose tissue using XOR genetically modified mice...
  47. pmc 8-oxoguanine causes spontaneous de novo germline mutations in mice
    Mizuki Ohno
    Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Sci Rep 4:4689. 2014
    ....
  48. ncbi DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan Global Medical Science Education Unit, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan Electronic address
    Biochem Pharmacol 89:340-8. 2014
    ..This is the first report to show that DIF-1 inhibits tumor growth in vivo, consistent with its in-vitro action, suggesting that this compound may have potential as a novel anti-tumor agent. ..
  49. ncbi Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome
    Mehrdad Behmanesh
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    DNA Res 12:39-51. 2005
    ..ITPA protein was mostly detected in the cytoplasm, to a lesser extent in the nuclei of neurons in the brain, and also those of hepatocytes, epithelial cells lining the bile duct, and endothelial cells lining the portal vein in the liver...
  50. doi Characterization of galectin-1-positive cells in the mouse hippocampus
    Kosuke Kajitani
    aDivision of Neurofunctional Genomics, Medical Institute of Bioregulation bDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka cDepartment of Biotechnology, Maebashi Institute of Technology, Maebashi, Gunma dTechnoMaster Co Ltd, Yokohama, Japan
    Neuroreport 25:171-6. 2014
    ..These results indicate that gal-1 is expressed in interneurons that also express β-tubulin III and gal-1 may be a novel marker for interneuron subpopulations in the hippocampus. ..
  51. ncbi Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains
    Hideomi Hamasaki
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 34:284-90. 2014
    ..Because it has been reported that HGF is also up-regulated around senile plaques, β-amyloid deposition might be associated with astrocytosis through the HGF signaling pathway. ..
  52. pmc Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes
    Kyota Fujita
    Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Oxid Med Cell Longev 2012:324256. 2012
    ..In this paper, we discuss how the expression levels of these antioxidant enzymes are regulated. We also introduce recent advances in the therapeutic uses of medical gases against neurodegenerative diseases...
  53. doi DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis
    Sugako Oka
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Sci 102:677-82. 2011
    ..We thus propose that MUTYH suppresses tumorigenesis under conditions of oxidative stress by inducing cell death and by suppressing mutagenesis...
  54. doi Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines
    Yukio Nishimura
    Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Int J Oncol 41:1520-30. 2012
    ....
  55. ncbi Characterization of the genomic structure and expression of the mouse Apex2 gene
    Yasuhito Ide
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Fukuoka 812 8582, Japan
    Genomics 81:47-57. 2003
    ..In serum-stimulated BALB/c 3T3 cells, the level of Apex2 mRNA was transiently increased and the level of APEX2 reached a maximum in the late S phase, thus indicating that APEX2 may participate in postreplicative base excision repair...
  56. ncbi Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney
    Kazuhiko Tsuruya
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    DNA Repair (Amst) 2:211-29. 2003
    ....
  57. ncbi Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: the Hisayama Study
    Hisatomi Arima
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Cancer Prev 15:196-201. 2006
    ..77; 95% confidence interval 1.04-3.00; P=0.03). In conclusion, our findings suggest that ACE genotype DD enhances the association between smoking and cancer death in the general population...
  58. ncbi Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant
    Hirokazu Furuya
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Pharmacol 69:503-16. 2005
    ..This system makes it easy to evaluate the toxic effects of expanded CTG repeats and therefore should be useful for screening other DM1 treatments for their efficacies...
  59. ncbi The 4th International Symposium on 3R; DNA replication, recombination and repair
    Yoshizumi Ishino
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Fukuoka, Japan
    Genes Genet Syst 79:53-63. 2004
  60. doi Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus
    Yasunari Sakai
    Department of Pediatrics, Kyushu University Hospital, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan Electronic address
    Eur J Med Genet 56:475-83. 2013
    ..We propose that individuals with 5q14.3 deletion syndrome may exhibit neuroendocrine phenotypes through the functional loss of MEF2C in the postnatal hypothalamus...
  61. ncbi Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines
    Shunsaku Yamamoto
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Anticancer Res 28:1585-91. 2008
    ..Histone deacetylase (HDAC) inhibitor exert anticancer effects, but have not been tested in chondrosarcoma...
  62. ncbi Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages
    Ping Wei
    Division of Clinical Immunology, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Biochem 138:399-412. 2005
    ..1/AP-1 complex formation on EMSA. From these results, we concluded that the Ets/AP-1 site is an important cis-acting element that regulates the ADRP gene expression in macrophages...
  63. ncbi Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression
    Katsuhisa Yamazaki
    Medical Institute of Bioregulation, Kyushu University, and CREST, Japan Science and Technology Corporation, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 278:13585-9. 2003
    ..Taken together, our results suggest that Elongin A regulates transcription of a subset but not all of genes and reveal a linkage between Elongin A function and cell cycle progression...
  64. pmc Therapeutic effects of hydrogen in animal models of Parkinson's disease
    Kyota Fujita
    Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Parkinsons Dis 2011:307875. 2011
    ..Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD...
  65. ncbi Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain
    Takashi Iida
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Acta Neuropathol 103:20-5. 2002
    ..Our results indicate that the repair enzyme for oxidative damage in mitochondrial DNA may not function appropriately in AD, and thus oxidative DNA damage in mitochondria may be involved in the pathomechanism of AD...
  66. ncbi A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas
    Qingguo Yuan
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 23:203-9. 2003
    ..Thus, it is suggested that MGMT expression is reduced during malignant transformation of diffusely infiltrating astrocytomas, and that mutant p53 protein might be associated with down regulation of the MGMT expression...
  67. ncbi A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1
    Yasunari Sakai
    Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University and CREST, Japan Science and Technology Corporation, Fukuoka 812 8582, Japan
    J Biol Chem 277:8579-87. 2002
    ....
  68. ncbi Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease
    Takeo Arai
    Department of Neurology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, 113 8421, Japan
    Acta Neuropathol 112:139-45. 2006
    ..Our results suggest that hMUTYH might be a useful marker of oxidative stress and that oxidative stress and genomic instability are important in the PD disease process...
  69. ncbi [Defense mechanisms against oxidative damage in mitochondrial genome]
    Yusaku Nakabeppu
    Tanpakushitsu Kakusan Koso 50:1770-3. 2005
  70. ncbi Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates
    Masaki Mishima
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    J Biol Chem 279:33806-15. 2004
    ..We also show that MTH1 catalyzes hydrolysis of 8-oxo-dGTP through nucleophilic substitution of water at the beta-phosphate...
  71. ncbi Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein
    Masayuki Takahashi
    UMR 216, Centre National de la Recherche Scientifique and Institut Curie, 91405 Orsay, France
    J Mol Biol 319:129-39. 2002
    ..Positively charged metal ions probably act by neutralizing the negatively charged nucleotide phosphate groups. (c) 2002 Elsevier Science Ltd...
  72. pmc The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells
    Maria Teresa Russo
    Chemical Carcinogenesis Unit, Istituto Superiore di Sanita, Rome, Italy
    Mol Cell Biol 24:465-74. 2004
    ..Our findings indicate that incorporation of oxidized purines from the dNTP pool may contribute significantly to the extreme genetic instability of MMR-defective human tumors...
  73. ncbi Mutagenic target for hydroxyl radicals generated in Escherichia coli mutant deficient in Mn- and Fe- superoxide dismutases and Fur, a repressor for iron-uptake systems
    Tatsuo Nunoshiba
    Department of Biomolecular Science, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8577, Japan
    DNA Repair (Amst) 1:411-418. 2002
    ..coli was similar to that in sodAB fur strain. These results suggested that the targets contributing to oxidative mutagenesis in sodAB fur strain are nucleotides such as dGTP and dATP, rather than DNA...
  74. ncbi Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma
    Naohiko Kohya
    Department of Surgery, Saga Medical School, Saga, Japan
    Ann Surg Oncol 9:371-9. 2002
    ..The O(6)-methyl G:T mismatch is recognized by the mismatch-repair (MMR) pathway. The biliary duct is highly exposed to alkylating agents because of its anatomical location...
  75. ncbi 8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis
    Makoto Kunisada
    Division of Dermatology, Clinical Molecular Medicine, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Res 65:6006-10. 2005
    ..These results clearly indicate that oxidative DNA damage induced by sunlight plays an important role in the development of skin cancers...
  76. ncbi [MTH1, an oxidized purine nucleoside triphosphatase suppresses mitochondrial dysfunction and cell death caused by oxidative stress]
    Yusaku Nakabeppu
    Tanpakushitsu Kakusan Koso 50:940-8. 2005
  77. pmc Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair
    Keiji Hashimoto
    Laboratory of Chemical Biology, Department of Pharmacological Sciences, State University of New York, Stony Brook, NY 11794 8651, USA
    Nucleic Acids Res 32:5928-34. 2004
    ....
  78. pmc Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis
    Shinya Akatsuka
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Am J Pathol 169:1328-42. 2006
    ..This versatile technique would introduce a novel research area as a high-throughput screening method for critical genomic loci under oxidative stress...
  79. ncbi Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders
    Jiro Fukae
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421, Tokyo, Japan
    Acta Neuropathol 109:256-62. 2005
    ..Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD...
  80. ncbi Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein
    Hiroyuki Kamiya
    Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812
    J Biochem 140:843-9. 2006
    ..These results clarify the effects of the 2-amino group and the two-ring system of the purine base on the recognition by the human MTH1 protein...
  81. pmc Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP
    Teruya Nakamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1283-5. 2006
    ..0, b = 59.0, c = 65.9 A, beta = 90.7 degrees and a = 59.2, b = 67.3, c = 80.0 A, respectively. Their diffraction data were collected at resolutions of 1.95 and 2.22 A, respectively...
  82. ncbi 8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog
    Katsuyoshi Fujikawa
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, 807 8555, Kitakyushu, Japan
    FEBS Lett 512:149-51. 2002
    ..The kinetic parameters revealed that 8-chloro-dGTP was degraded by hMTH1 with 50% efficiency as compared with that of 8-hydroxy-dGTP. This result suggests that 8-chloro-dGTP is an intrinsic substrate for hMTH1...
  83. pmc A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae
    Tatsuo Nunoshiba
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Aoba ku, Sendai, Miyagi 980 8577, Japan
    Nucleic Acids Res 32:5339-48. 2004
    ..From these results, we conclude that YLR151c has an ability to prevent spontaneous mutagenesis via sanitization of oxidized nucleotides, and that it may be the functional homologue of E.coli MutT in S.cerevisiae...
  84. ncbi Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer
    Tetsuji Nakagawachi
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Oncogene 22:8835-44. 2003
    ..Furthermore, MeCP2 preferentially bound to the CpG-methylated island in the MGMT negative line. Given these results, we propose a model for gene silencing of MGMT that is dependent on the epigenetic state in cancer...
  85. ncbi XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair
    Anna Campalans
    Departement de Radiobiologie et Radiopathologie, CEA, UMR217 CNRS CEA, 18 route du Panorama, F 92265 Fontenay aux Roses, France
    DNA Repair (Amst) 4:826-35. 2005
    ..XRCC1 would then coordinate the subsequent enzymatic steps and modulate the activities of all the proteins involved...
  86. ncbi Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer
    Makoto Kunisada
    Division of Dermatology, Clinical Molecular Medicine, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Invest Dermatol 127:2865-71. 2007
    ..JID JOURNAL CLUB ARTICLE: For questions, answers and open discussion about this article please go to http://network.nature.com/...
  87. ncbi Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs
    Hiroyuki Kamiya
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Mol Biol 336:843-50. 2004
    ..These results clarify the effects of the anti/syn conformation and the functional groups on the 2 and 6 positions of the purine ring on the recognition by the human MTH1 protein...
  88. ncbi Replication-associated repair of adenine:8-oxoguanine mispairs by MYH
    Harutoshi Hayashi
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Curr Biol 12:335-9. 2002
    ..Expression of a mutant MYH in which the PCNA binding motif was disrupted did not increase the repair efficiency, thus suggesting that the interaction between PCNA and MYH is critical for MYH-initiated repair of A:8-oxoG...
  89. ncbi RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS
    Isao Kuraoka
    Laboratories for Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    DNA Repair (Amst) 6:841-51. 2007
    ..These results suggest that SII is important for preventing cellular death due to oxidative DNA damage, assisting RNAPII to bypass 8-oxoG...