Hiroko Yamashita

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. pmc Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion
    Yasuhiro Okumura
    Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    BMC Cancer 8:287. 2008
  2. pmc Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer
    Kazuharu Kai
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    BMC Cancer 8:262. 2008
  3. pmc Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer
    Hiroko Yamashita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Breast Cancer Res 7:R753-64. 2005
  4. ncbi Dominant-negative Stat5 inhibits growth and induces apoptosis in T47D-derived tumors in nude mice
    Hiroko Yamashita
    Department of Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 95:662-5. 2004
  5. pmc Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
    Hiroko Yamashita
    Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
    Breast Cancer Res 6:R24-30. 2004
  6. ncbi Immunohistochemical evaluation of hormone receptor status for predicting response to endocrine therapy in metastatic breast cancer
    Hiroko Yamashita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Nagoya 467 8601, Japan
    Breast Cancer 13:74-83. 2006
  7. pmc p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer
    Hiroko Yamashita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya 467 8601, Japan
    Breast Cancer Res 8:R48. 2006
  8. doi Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer
    Hiroko Yamashita
    Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Endocr Relat Cancer 15:755-63. 2008
  9. ncbi The role of Stat5 in estrogen receptor-positive breast cancer
    Hiroko Yamashita
    Department of Surgery II, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya 467 8601, Japan
    Breast Cancer 9:312-8. 2002
  10. doi Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics, and prognosis
    H Yamashita
    Oncology, Immunology, and Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Ann Oncol 22:1318-25. 2011

Collaborators

Detail Information

Publications55

  1. pmc Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion
    Yasuhiro Okumura
    Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    BMC Cancer 8:287. 2008
    ..Identification of biological differences between DCIS and DCIS-Mi may aid in understanding of the nature and causes of the progression of DCIS to invasiveness...
  2. pmc Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer
    Kazuharu Kai
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    BMC Cancer 8:262. 2008
    ..In addition, few studies have analyzed LOH status at the ATBF1-A locus, located in the 16q22 minimal region...
  3. pmc Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer
    Hiroko Yamashita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Breast Cancer Res 7:R753-64. 2005
    ..However, the factors and pathways responsible for endocrine resistance are still poorly identified...
  4. ncbi Dominant-negative Stat5 inhibits growth and induces apoptosis in T47D-derived tumors in nude mice
    Hiroko Yamashita
    Department of Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 95:662-5. 2004
    ..Our results indicate the possibility of using dominant-negative Stat5 to induce apoptosis in certain Stat5-activated breast cancers...
  5. pmc Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
    Hiroko Yamashita
    Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
    Breast Cancer Res 6:R24-30. 2004
    ..Although the available studies suggest that these factors might indeed be helpful in making treatment decisions in cancer patients, their clinical usefulness is still controversial...
  6. ncbi Immunohistochemical evaluation of hormone receptor status for predicting response to endocrine therapy in metastatic breast cancer
    Hiroko Yamashita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Nagoya 467 8601, Japan
    Breast Cancer 13:74-83. 2006
    ..It is critical to evaluate hormone receptor status when considering response to endocrine therapy...
  7. pmc p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer
    Hiroko Yamashita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya 467 8601, Japan
    Breast Cancer Res 8:R48. 2006
    ..However, the factors and pathways responsible for endocrine resistance are still poorly identified...
  8. doi Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer
    Hiroko Yamashita
    Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Endocr Relat Cancer 15:755-63. 2008
    ....
  9. ncbi The role of Stat5 in estrogen receptor-positive breast cancer
    Hiroko Yamashita
    Department of Surgery II, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya 467 8601, Japan
    Breast Cancer 9:312-8. 2002
    ..Our study indicates that targeting Stat5 may represent a new strategy to suppress estrogen receptor activity and induce apoptosis in Stat5-activated, ER-positive breast cancer...
  10. doi Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics, and prognosis
    H Yamashita
    Oncology, Immunology, and Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Ann Oncol 22:1318-25. 2011
    ..The incidence of breast cancer in Japanese women has doubled in all age groups over the past two decades...
  11. ncbi Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer
    H Yamashita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
    Endocr Relat Cancer 13:885-93. 2006
    ..Our data suggest that the expression of Stat5 is helpful in selecting patients who may benefit from endocrine therapy...
  12. doi Current research topics in endocrine therapy for breast cancer
    Hiroko Yamashita
    Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Int J Clin Oncol 13:380-3. 2008
    ..New insights into ER biology and progress in the understanding of resistance mechanisms are generating tremendous promise for new therapeutic opportunities to target resistance and improve disease outcomes...
  13. doi Predictors of response to exemestane as primary endocrine therapy in estrogen receptor-positive breast cancer
    Hiroko Yamashita
    Oncology, Immunology, and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Sci 100:2028-33. 2009
    ..Thus, the analysis of factors involved in the estrogen-dependent growth-signaling pathways may be useful in identifying patients responsive to exemestane...
  14. ncbi Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Medical School, Nagoya City University Hospital, Kawasumi 1, 467 8601, Nagoya, Japan
    Breast Cancer Res Treat 94:11-6. 2005
    ..These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression...
  15. ncbi NCOR1 mRNA is an independent prognostic factor for breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Kawasumi 1, Nagoya 467 8601, Japan
    Cancer Lett 237:123-9. 2006
    ..Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer...
  16. ncbi p33(ING1b) stimulates the transcriptional activity of the estrogen receptor alpha via its activation function (AF) 2 domain
    Tatsuya Toyama
    Department of Surgery II, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Steroid Biochem Mol Biol 87:57-63. 2003
    ..Our data presented here demonstrate that p33(ING1b) acts like a coactivator for ERalpha and stimulates estrogen-induced ERalpha transcriptional activity consistent with a function for p33(ING1b) in chromatin remodeling...
  17. ncbi ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Medical School, Nagoya, Japan
    Clin Cancer Res 11:193-8. 2005
    ..This led us to hypothesize that there was a link between levels of ATBF1 expression and the metastatic potential of breast cancer and also, therefore, the prognosis of these patients...
  18. pmc Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University, Medical School, Nagoya, Japan
    Breast Cancer Res 5:R250-6. 2003
    ..In addition, previous studies into aromatase gene expression and clinicopathologic factors are limited...
  19. doi Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers
    Maho Hamaguchi
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho, Nagoya, Japan
    Jpn J Clin Oncol 38:734-42. 2008
    ..We focused on identifying common genotypes for ER-positive breast cancer in premenopausal Japanese women...
  20. ncbi Prognostic significance of insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 expression in breast cancer
    Keiko Mita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Jpn J Clin Oncol 37:575-82. 2007
    ..Investigation of IGFBP-4 and IGFBP-5 expression would provide important information for predicting prognosis and endocrine responsiveness...
  21. ncbi HDAC6 expression is correlated with better survival in breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
    Clin Cancer Res 10:6962-8. 2004
    ..This led us to hypothesize that there was a link between levels of HDAC6 expression and the metastatic potential of breast cancer and also, therefore, the prognosis of these patients...
  22. doi Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women
    Nobuyasu Yoshimoto
    Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Cancer Sci 102:2065-72. 2011
    ..Further validation studies will clarify appropriate risk groups for preventive therapy...
  23. doi Patient's perceived need and psychological distress and/or quality of life in ambulatory breast cancer patients in Japan
    Tatsuo Akechi
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Aichi, Japan
    Psychooncology 20:497-505. 2011
    ..The purposes of this study were to investigate the association between patients' perceived needs and psychological distress and/or quality of life (QOL) and to clarify the characteristics of patients with a high degree of unmet needs...
  24. doi miR-1290 and its potential targets are associated with characteristics of estrogen receptor α-positive breast cancer
    Yumi Endo
    Departments of Oncology, Immunology and Surgery Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Japan
    Endocr Relat Cancer 20:91-102. 2013
    ..Our results suggest that miR-1290 and its potential targets might be associated with characteristics of ER-positive breast cancer...
  25. doi High estrogen receptor expression and low Ki67 expression are associated with improved time to progression during first-line endocrine therapy with aromatase inhibitors in breast cancer
    Yumi Endo
    Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Int J Clin Oncol 16:512-8. 2011
    ..However, many breast cancer patients with tumors expressing ER are unresponsive to aromatase inhibitors, and all patients with advanced disease eventually develop resistance to the therapy...
  26. pmc Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers
    Tatsuya Toyama
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    BMC Cancer 8:309. 2008
    ..Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these proteins...
  27. doi miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer
    Naoto Kondo
    Oncology, Immunology, and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Res 68:5004-8. 2008
    ..Our results suggest that miR-206 could be a novel candidate for endocrine therapy that targets only ERalpha in breast cancer...
  28. pmc Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients
    Tatsuya Toyama
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Breast Cancer Res 9:R34. 2007
    ..We investigated whether these SNPs were associated with patient outcome and the effect of adjuvant systemic therapy...
  29. doi No association between CYP2D6*10 genotype and survival of node-negative Japanese breast cancer patients receiving adjuvant tamoxifen treatment
    Tatsuya Toyama
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Jpn J Clin Oncol 39:651-6. 2009
    ..The CYP2D6 enzyme plays a major role in converting tamoxifen to its active metabolites. We investigated whether there is an association between the CYP2D6*10 allele and clinical outcome in node-negative Japanese breast cancer patients...
  30. doi Patients' supportive care needs and psychological distress in advanced breast cancer patients in Japan
    Megumi Uchida
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Jpn J Clin Oncol 41:530-6. 2011
    ....
  31. ncbi Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells
    Hiroko Yamashita
    Department of Surgery II, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Oncogene 22:1638-52. 2003
    ..The present study indicates that overexpression of a dominant-negative variant of Stat5 suppresses ER transcriptional activity and induces apoptosis in estrogen-responsive breast cancer tissue culture cells...
  32. doi High expression of microRNA-210 is an independent factor indicating a poor prognosis in Japanese triple-negative breast cancer patients
    Tatsuya Toyama
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Clin Oncol 42:256-63. 2012
    ..Here, we assessed miR-210 expression in Japanese triple-negative breast cancers and determined its clinical significance...
  33. ncbi Expression of estrogen receptor beta wild-type and its variant ERbetacx/beta2 is correlated with better prognosis in breast cancer
    Hiroshi Sugiura
    Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Clin Oncol 37:820-8. 2007
    ..The clinical value of estrogen receptor (ER) beta and its variants has been investigated. However, reported results have frequently been discordant...
  34. doi Oncologists' recognition of supportive care needs and symptoms of their patients in a breast cancer outpatient consultation
    Toru Okuyama
    Division of Psycho oncology and Palliative Care, Nagoya City University Hospital, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Jpn J Clin Oncol 41:1251-8. 2011
    ..The purpose of this study was to investigate the accuracy of oncologists' recognition of their patients' supportive care needs and symptoms in breast cancer outpatient consultation in Japan...
  35. ncbi Reduced expression of the breast cancer metastasis suppressor 1 mRNA is correlated with poor progress in breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
    Clin Cancer Res 12:6410-4. 2006
    ..However, its clinical importance for breast cancer patients remains undetermined. This prompted us to investigate its expression level in breast cancer patients to clarify its clinical significance...
  36. ncbi Clinical significance of the expression of estrogen receptors alpha and beta for endocrine therapy of breast cancer
    Hirotaka Iwase
    Department of Oncology and Endocrinology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, 467 8601, Nagoya, Japan
    Cancer Chemother Pharmacol 52:S34-8. 2003
    ..The results concerning ERbeta are not yet fully understood; further investigations and evaluations should analyze the role of ERbeta wild-type and variant type in breast cancer treatment...
  37. doi Perceived needs, psychological distress and quality of life of elderly cancer patients
    Tatsuo Akechi
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Jpn J Clin Oncol 42:704-10. 2012
    ..Very few findings regarding the perceived needs of elderly cancer patients have been reported. This study investigated needs and psychological distress perceived by and/or quality of life of elderly cancer patients...
  38. ncbi Biweekly paclitaxel in patients with metastatic breast cancer
    Tatsuya Toyama
    Department of Surgery II, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Int J Clin Oncol 8:357-61. 2003
    ..This study was conducted to evaluate the efficacy and the toxicity of paclitaxel administered as a biweekly 1-h infusion (120 mg/m2)...
  39. doi Distinct expressions of microRNAs that directly target estrogen receptor α in human breast cancer
    Nobuyasu Yoshimoto
    Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
    Breast Cancer Res Treat 130:331-9. 2011
    ..Our results suggest that miRNAs that directly target ERα have distinct roles in not only regulating ERα but also regulating other target genes in human breast cancer...
  40. pmc Reproductive history and breast cancer risk
    Shunzo Kobayashi
    Department of Breast and Endocrine Surgery, Nagoya City West Medical Center, 1 1 1, Hirate cho, Kita ku, Nagoya, 462 8508, Japan
    Breast Cancer 19:302-8. 2012
    ..In this review, the significance of reproductive history with regard to the risk of breast cancers will be discussed, focusing on the age of first full-term birth and post lactation involution of the breast...
  41. ncbi Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer
    Tatsuya Toyama
    Department of Surgery II, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Cancer Lett 189:97-102. 2003
    ..Our data suggest that reduced Syk expression in breast cancers is associated with distant metastasis and poor prognosis; therefore, Syk is considered to be a potential tumor suppressor and anti-metastasis gene in human breast cancer...
  42. doi Impact of prophylactic pyridoxine on occurrence of hand-foot syndrome in patients receiving capecitabine for advanced or metastatic breast cancer
    Nobuyasu Yoshimoto
    Department of Breast Oncology, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    Breast Cancer 17:298-302. 2010
    ..We conducted a study to assess the impact of prophylactic pyridoxine on HFS...
  43. ncbi Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    Cancer Res 67:11353-8. 2007
    ..Thus, these data suggested that GPX2 may be involved in mammary carcinogenesis and cell proliferation in both rats and humans, indicating that GPX2 may be a novel target for the prevention and therapy of breast cancer...
  44. ncbi Clinical significance of AIB1 expression in human breast cancer
    H Iwase
    Department of Oncology and Endocrinology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya, Japan
    Breast Cancer Res Treat 80:339-45. 2003
    ..In conclusion, AIB1 nuclear expression was correlated with the estrogen receptor alpha status, and patients with AIB1 nuclear expression tended to be successfully treated by hormonal therapy...
  45. ncbi Microsatellite instability in sporadic human breast cancers
    T Toyama
    Department of Surgery II, Nagoya City University Medical School, Japan
    Int J Cancer 68:447-51. 1996
    ..Thus, the mechanism of RER in sporadic human breast cancer may be independent of the multi-step carcinogenesis caused by the alterations of oncogenes and tumor-suppressor genes...
  46. ncbi Sequence variants of the estrogen receptor (ER) gene found in breast cancer patients with ER negative and progesterone receptor positive tumors
    H Iwase
    Imperial Cancer Research Fund, Clinical Oncology Unit, Guy s Hospital, London, UK
    Cancer Lett 108:179-84. 1996
    ..Although the frequency of these polymorphic sites was not correlated with hormone receptor status, the variant in codon 325 tended to be seen more frequently in breast cancer patients than in non-cancer control cases (P = 0.057)...
  47. ncbi Genetic and epigenetic alterations of the estrogen receptor gene and hormone independence in human breast cancer
    H Iwase
    Second Department of Surgery, Nagoya City University Medical School, Japan
    Oncology 55:11-6. 1998
    ..Additionally, the DNA methylation of the ER gene itself may control ER expression. These epigenetic changes can play an important role in the loss of hormone dependence in breast cancer...
  48. pmc DNA methylation analysis at distal and proximal promoter regions of the oestrogen receptor gene in breast cancers
    H Iwase
    Department of Surgery II, Nagoya City University Medical School, Japan
    Br J Cancer 80:1982-6. 1999
    ..It was suggested that this epigenetic change might control ER-alpha expression, and might play an important role in the loss of hormone-dependence in breast cancer...
  49. ncbi Successful management of breast cancer with liver metastases with medroxyprogesterone acetate treatment
    T Toyama
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Int J Clin Oncol 6:306-9. 2001
    ..Importantly, the patient's quality of life has remained favorable for several years after the partial response was achieved...
  50. doi Reliability and validity of the Japanese version of the Short-form Supportive Care Needs Survey questionnaire (SCNS-SF34-J)
    Toru Okuyama
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Psychooncology 18:1003-10. 2009
    ..The purpose of this study was to examine the psychometric property of the Japanese version of the Short-form Supportive Care Needs Survey questionnaire (SCNS-SF34-J)...
  51. ncbi Evaluation of oestrogen receptor beta wild-type and variant protein expression, and relationship with clinicopathological factors in breast cancers
    Y Omoto
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho ku, 467 8601, Nagoya, Japan
    Eur J Cancer 38:380-6. 2002
    ..Thirty-one (54%) breast cancer samples contained ERbetacx, whereas the corresponding tissue for normal breast samples stained positive in only two (9%)...
  52. ncbi Immunohistochemical analysis on biological markers in ductal carcinoma in situ of the breast
    H Iwase
    Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-ku, Nagoya 467-8601, Japan
    Breast Cancer 8:98-104. 2001
    ..The Van Nuys classification best defined the subgroups of DCIS with a distinct expression pattern of biological markers, and the best candidates for breast-conserving surgery...
  53. ncbi Ratio of expression of p16INK4a to p14ARF correlates with the progression of non-small cell lung cancer
    Satoru Moriyama
    Department of Surgery II, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Cancer Res 93:783-8. 2002
    ..005). The N1 - 3 tumors had significantly lower p16(INK4a) to p14(ARF) ratios than the N0 tumors (P = 0.014). Our results suggest that the ratio of expression of p16(INK4a) to p14(ARF) tends to decrease during the progression of NSCLC...
  54. ncbi Telomerase activity levels for evaluating the surgical margin in breast-conserving surgery
    Y Hara
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Surg Today 31:289-94. 2001
    ..These findings show that conducting a semiquantitative assay of telomerase activity is useful for evaluating the surgical margin in breast-conserving surgery...
  55. ncbi Endostatin gene therapy on murine lung metastases model utilizing cationic vector-mediated intravenous gene delivery
    Y Nakashima
    Department of Surgery II, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Gene Ther 10:123-30. 2003
    ..These findings suggested that the endostatin gene therapy, using cationic vector-mediated intravenous gene transfer, might be a feasible strategy for organ-targeted prevention and regulation of possible disseminated cancers...