Y Yabu

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint Antitrypanosomal effects of traditional Chinese herbal medicines on bloodstream forms of Trypanosoma brucei rhodesiense in vitro
    Y Yabu
    Department of Medical Zoology, Nagoya City University Medical School, Nagoya, Japan
    Southeast Asian J Trop Med Public Health 29:599-604. 1998
  2. ncbi request reprint Continuous growth of bloodstream forms of Trypanosoma brucei brucei in an axenic culture system containing a low concentration of serum
    Y Yabu
    Department of Medical Zoology, Nagoya City University Medical School, Nagoya, Japan
    Southeast Asian J Trop Med Public Health 29:591-5. 1998
  3. ncbi request reprint Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol
    Yoshisada Yabu
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitol Int 55:39-43. 2006
  4. ncbi request reprint Alternative oxidase (AOX) genes of African trypanosomes: phylogeny and evolution of AOX and plastid terminal oxidase families
    Takashi Suzuki
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi, Mizuho 467 8601 Nagoya, Japan
    J Eukaryot Microbiol 52:374-81. 2005
  5. ncbi request reprint Molecular cloning and characterization of Trypanosoma vivax alternative oxidase (AOX) gene, a target of the trypanocide ascofuranone
    Takashi Suzuki
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitol Int 53:235-45. 2004
  6. ncbi request reprint Direct evidence for cyanide-insensitive quinol oxidase (alternative oxidase) in apicomplexan parasite Cryptosporidium parvum: phylogenetic and therapeutic implications
    Takashi Suzuki
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Biochem Biophys Res Commun 313:1044-52. 2004
  7. ncbi request reprint The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice
    Yoshisada Yabu
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitol Int 52:155-64. 2003
  8. ncbi request reprint Trypanosoma brucei vacuolar protein sorting 41 (VPS41) is required for intracellular iron utilization and maintenance of normal cellular morphology
    S Lu
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitology 134:1639-47. 2007
  9. ncbi request reprint A role of mast cell glycosaminoglycans for the immunological expulsion of intestinal nematode, Strongyloides venezuelensis
    H Maruyama
    Department of Medical Zoology, Nagoya City University Medical School, Nagoya, Japan
    J Immunol 164:3749-54. 2000
  10. ncbi request reprint Leishmanicidal effect of curcumin in vitro
    Tatsuo Koide
    Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 25:131-3. 2002

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Antitrypanosomal effects of traditional Chinese herbal medicines on bloodstream forms of Trypanosoma brucei rhodesiense in vitro
    Y Yabu
    Department of Medical Zoology, Nagoya City University Medical School, Nagoya, Japan
    Southeast Asian J Trop Med Public Health 29:599-604. 1998
    ..which are the main components of san'o-shasin-to and oren-gedoku-to, showed the most powerful antitrypanosomal activity. The MEC and EC50 value of these crude drug ingredients were 30 and 60 microg/ml, and 20 and 36 microg/ml...
  2. ncbi request reprint Continuous growth of bloodstream forms of Trypanosoma brucei brucei in an axenic culture system containing a low concentration of serum
    Y Yabu
    Department of Medical Zoology, Nagoya City University Medical School, Nagoya, Japan
    Southeast Asian J Trop Med Public Health 29:591-5. 1998
    ..The trypanosomes propagated in this culture system for one year retained their infectivity for mice. This culture system was also shown to be useful for cloning of T.b. brucei GUT at 3.1 which is important for separation of mutants...
  3. ncbi request reprint Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol
    Yoshisada Yabu
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitol Int 55:39-43. 2006
    ..Our present results strongly suggest that ascofuranone is also an effective tool in chemotherapy against African trypanosomiasis in domestic animals...
  4. ncbi request reprint Alternative oxidase (AOX) genes of African trypanosomes: phylogeny and evolution of AOX and plastid terminal oxidase families
    Takashi Suzuki
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi, Mizuho 467 8601 Nagoya, Japan
    J Eukaryot Microbiol 52:374-81. 2005
    ....
  5. ncbi request reprint Molecular cloning and characterization of Trypanosoma vivax alternative oxidase (AOX) gene, a target of the trypanocide ascofuranone
    Takashi Suzuki
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitol Int 53:235-45. 2004
    ..29 +/- 0.00 nM). The non-cyclic transmission ability of T. vivax and the in vivo chemotherapeutic efficacy of ascofuranone against T. vivax and T. b. brucei infection are discussed in terms of these Km and Ki values...
  6. ncbi request reprint Direct evidence for cyanide-insensitive quinol oxidase (alternative oxidase) in apicomplexan parasite Cryptosporidium parvum: phylogenetic and therapeutic implications
    Takashi Suzuki
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Biochem Biophys Res Commun 313:1044-52. 2004
    ..The recombinant enzyme expressed in Escherichia coli showed quinol oxidase activity. This activity was insensitive to cyanide and highly sensitive to ascofuranone, a specific inhibitor of trypanosome AOX...
  7. ncbi request reprint The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice
    Yoshisada Yabu
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitol Int 52:155-64. 2003
    ..b. brucei infected mice. Our present results strongly suggest that consecutive administration of ascofuranone may be an effective chemotherapy for African trypanosomiasis...
  8. ncbi request reprint Trypanosoma brucei vacuolar protein sorting 41 (VPS41) is required for intracellular iron utilization and maintenance of normal cellular morphology
    S Lu
    Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitology 134:1639-47. 2007
    ..The present study demonstrates that TbVPS41 plays an important role in the intracellular iron utilization system as well as in the maintenance of normal cellular morphology...
  9. ncbi request reprint A role of mast cell glycosaminoglycans for the immunological expulsion of intestinal nematode, Strongyloides venezuelensis
    H Maruyama
    Department of Medical Zoology, Nagoya City University Medical School, Nagoya, Japan
    J Immunol 164:3749-54. 2000
    ..venezuelensis is inhibition by mast cell glycosaminoglycans of attachment and subsequent invasion of adult worms into intestinal epithelium...
  10. ncbi request reprint Leishmanicidal effect of curcumin in vitro
    Tatsuo Koide
    Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 25:131-3. 2002
    ..From a study to find anti-parasitic agents from natural resources, we found that curcumin showed the cytotoxicity against leishmania in vitro. The LD50 value of this activity was 37.6+/-3.5 microM...
  11. ncbi request reprint Purification of active recombinant trypanosome alternative oxidase
    Coichi Nihei
    Department of Biomedical Chemistry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FEBS Lett 538:35-40. 2003
    ..Kinetic analysis of the purified TAO revealed that the specific inhibitor ascofuranone is a competitive inhibitor of ubiquinol oxidase activity...
  12. ncbi request reprint Strain-specific difference in amino acid sequences of trypanosome alternative oxidase
    Yoshihisa Fukai
    Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Parasitol Int 51:195-9. 2002
    ..In this study, we found amino acid sequence of the C-terminal part of TAO from the strain that we are using, T. b. brucei TC221, is considerably different from that of the EATRO110 strain...
  13. ncbi request reprint Mutational analysis of the Trypanosoma vivax alternative oxidase: the E(X)6Y motif is conserved in both mitochondrial alternative oxidase and plastid terminal oxidase and is indispensable for enzyme activity
    Kosuke Nakamura
    Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 334:593-600. 2005
    ..Based on these findings, it appears that AOXs and PTOXs are a novel subclass of diiron carboxylate proteins that require the conserved motif E(X)(6)Y for enzyme activity...
  14. ncbi request reprint Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols
    Lu Shaohong
    Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Parasitol Int 55:63-8. 2006
    ..japonicum infection. Considering that artemether is more toxic, artesunate is currently one of the most efficient drugs against immature S. mansoni...
  15. ncbi request reprint Overproduction of highly active trypanosome alternative oxidase in Escherichia coli heme-deficient mutant
    Yoshihisa Fukai
    Department of Biomedical Chemistry, Graduate School of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Parasitol Int 52:237-41. 2003
    ....