K Wakai

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population
    Takahiro Higashibata
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Lipids Health Dis 11:150. 2012
  2. pmc Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study
    Rieko Okada
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Nephrol 13:2. 2012
  3. pmc Effects of a low-carbohydrate diet on glycemic control in outpatients with severe type 2 diabetes
    Hajime Haimoto
    Department of Internal Medicine, Haimoto Clinic, 1 80 Yayoi, Kasugai, Aichi 486 0838, Japan
    Nutr Metab (Lond) 6:21. 2009
  4. pmc Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet: a crossover meal tolerance study
    Hajime Haimoto
    Department of Internal Medicine, Haimoto Clinic, 1 80 Yayoi, Kasugai, Aichi 486 0838, Japan
    Nutr Metab (Lond) 6:52. 2009
  5. pmc Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population
    Nobuyuki Hamajima
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Med Genet 12:33. 2011
  6. pmc Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Gastroenterol 9:51. 2009
  7. ncbi request reprint The JICA training course, community-based cancer prevention for the Asian and Pan-Pacific countries, fiscal year 2006 (epidemiological approach)
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Asian Pac J Cancer Prev 8:150-4. 2007
  8. ncbi request reprint A review of food frequency questionnaires developed and validated in Japan
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Epidemiol 19:1-11. 2009
  9. pmc Liver cancer risk, coffee, and hepatitis C virus infection: a nested case-control study in Japan
    K Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Br J Cancer 97:426-8. 2007
  10. ncbi request reprint Longitudinal Evaluation of Multi-phasic, Odontological and Nutritional Associations in Dentists (LEMONADE Study): study design and profile of nationwide cohort participants at baseline
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Epidemiol 19:72-80. 2009

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. pmc eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population
    Takahiro Higashibata
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Lipids Health Dis 11:150. 2012
    ..The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia...
  2. pmc Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study
    Rieko Okada
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Nephrol 13:2. 2012
    ....
  3. pmc Effects of a low-carbohydrate diet on glycemic control in outpatients with severe type 2 diabetes
    Hajime Haimoto
    Department of Internal Medicine, Haimoto Clinic, 1 80 Yayoi, Kasugai, Aichi 486 0838, Japan
    Nutr Metab (Lond) 6:21. 2009
    ..The effectiveness of the diet may be comparable to that of insulin therapy...
  4. pmc Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet: a crossover meal tolerance study
    Hajime Haimoto
    Department of Internal Medicine, Haimoto Clinic, 1 80 Yayoi, Kasugai, Aichi 486 0838, Japan
    Nutr Metab (Lond) 6:52. 2009
    ..With respect to energy metabolism, acute metabolic responses to high-carbohydrate meals (HCMs) have not been determined in LCD patients with T2DM...
  5. pmc Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population
    Nobuyuki Hamajima
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Med Genet 12:33. 2011
    ..This study examined serum uric acid (SUA) distribution according to SLC22A12 W258X genotype in a general Japanese population...
  6. pmc Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Gastroenterol 9:51. 2009
    ....
  7. ncbi request reprint The JICA training course, community-based cancer prevention for the Asian and Pan-Pacific countries, fiscal year 2006 (epidemiological approach)
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Asian Pac J Cancer Prev 8:150-4. 2007
    ....
  8. ncbi request reprint A review of food frequency questionnaires developed and validated in Japan
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Epidemiol 19:1-11. 2009
    ..Because dietary habits vary greatly, the FFQ must be tailored for use with specific populations. The usefulness of FFQs in Japan was assessed by reviewing questionnaires developed and validated in that country...
  9. pmc Liver cancer risk, coffee, and hepatitis C virus infection: a nested case-control study in Japan
    K Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Br J Cancer 97:426-8. 2007
    ..49 (0.25-0.96), 0.31 (0.11-0.85), and 0.75 (0.29-1.92) in all cases, in HCV-positive and in HCV-negative individuals, respectively...
  10. ncbi request reprint Longitudinal Evaluation of Multi-phasic, Odontological and Nutritional Associations in Dentists (LEMONADE Study): study design and profile of nationwide cohort participants at baseline
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Epidemiol 19:72-80. 2009
    ..Herein, we describe the study design and the profile of the participants at baseline...
  11. ncbi request reprint Serum insulin-like growth factors, insulin-like growth factor-binding protein-3, and risk of lung cancer death: a case-control study nested in the Japan Collaborative Cohort (JACC) Study
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 93:1279-86. 2002
    ..A higher level of circulating IGFBP-3 and / or IGF-II may decrease lung cancer risk. Elevated serum IGF-I may increase the risk, but this could partly be attributable to latent tumors...
  12. ncbi request reprint Decrease in risk of lung cancer death in Japanese men after smoking cessation by age at quitting: pooled analysis of three large-scale cohort studies
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:584-9. 2007
    ....
  13. ncbi request reprint Psychological attitudes and risk of breast cancer in Japan: a prospective study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Cancer Causes Control 18:259-67. 2007
    ..To examine the association between psychological factors and the risk of breast cancer prospectively in a non-Western population...
  14. ncbi request reprint Risk factors for IgA nephropathy: a case-control study in Japan
    K Wakai
    Department of Preventive Medicine and the Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Am J Kidney Dis 33:738-45. 1999
    ..Episodes of tonsillitis and exposure to organic solvents were found not to be associated with the risk in the present study. Our findings may provide some clues to the cause of IgAN...
  15. ncbi request reprint Risk factors for IgA nephropathy: a case-control study with incident cases in Japan
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nephron 90:16-23. 2002
    ..Our previous study with prevalent cases suggested that some genetic, immunological and lifestyle-related factors increased the risk of immunoglobulin A nephropathy (IgAN). To confirm this hypothesis, we conducted another case-control study...
  16. ncbi request reprint Dietary intake and sources of isoflavones among Japanese
    K Wakai
    Department of Preventive Medicine, Nagoya University School of Medicine, Japan
    Nutr Cancer 33:139-45. 1999
    ..1% for daidzein and genistein. Therefore, we should use other methods, such as food-frequency questionnaires, focusing on the four major sources of isoflavones, to assess individual isoflavone intake...
  17. ncbi request reprint Associations of medical status and physical fitness with periodontal disease
    K Wakai
    Department of Preventive Medicine, Nagoya University School of Medicine, Japan
    J Clin Periodontol 26:664-72. 1999
    ..Although these new potential risk factors should be further investigated for their causal relationship, our findings suggested a close relationship of oral health to medical status and physical fitness...
  18. ncbi request reprint Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
    Kenji Wakai
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Epidemiol 21:223-35. 2011
    ..To detect gene-environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005...
  19. ncbi request reprint Foods and nutrients in relation to bladder cancer risk: a case-control study in Aichi Prefecture, Central Japan
    K Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Nutr Cancer 38:13-22. 2000
    ..75, 0.54, and 0.66 and 0.55, 0.54, and 0.60, respectively). Monounsaturated fatty acids had an inverse association with bladder cancer risk in men...
  20. doi request reprint Lung cancer risk and consumption of vegetables and fruit: an evaluation based on a systematic review of epidemiological evidence from Japan
    Kenji Wakai
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Clin Oncol 41:693-708. 2011
    ..To re-assess this issue, we reviewed data from Japanese epidemiological studies...
  21. ncbi request reprint Time spent walking or exercising and blood levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3): A large-scale cross-sectional study in the Japan Collaborative Cohort study
    Kenji Wakai
    Department of Preventive Medicine, Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    Asian Pac J Cancer Prev 10:23-7. 2009
    ..048). Our findings may partly explain the protective effects of physical activity against several sites of cancer...
  22. ncbi request reprint Decrease in risk of lung cancer death in males after smoking cessation by age at quitting: findings from the JACC study
    K Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 92:821-8. 2001
    ..The absolute rate, however, substantially decreased after smoking cessation even in those who quit at ages 60 - 69, reflecting the high mortality rate among continuing smokers in the elderly...
  23. doi request reprint Tooth loss and intakes of nutrients and foods: a nationwide survey of Japanese dentists
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Community Dent Oral Epidemiol 38:43-9. 2010
    ..To clarify the association of tooth loss with dietary intakes among dentists, for whom sufficient dental care is available...
  24. ncbi request reprint Sleep patterns and total mortality: a 12-year follow-up study in Japan
    M Kojima
    Department of Preventive Medicine, Nagoya University School of Medicine, Japan
    J Epidemiol 10:87-93. 2000
    ..89). These findings were almost unchanged after adjustment for sleep duration and other confounders. Poor self-reported quality of sleep seemed to be associated with an increased risk of mortality independently of sleep duration...
  25. doi request reprint No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Gastric Cancer 13:43-9. 2010
    ..We investigated the association of the AICDA 7888 C/T polymorphism with H. pylori infection and the risk of gastric cancer and atrophic gastritis in Japanese subjects...
  26. ncbi request reprint Favorable life-style modification and attenuation of cardiovascular risk factors
    R Yamamoto
    Department of Geriatrics, Nagoya University School of Medicine, Japan
    Jpn Circ J 63:184-8. 1999
    ....
  27. ncbi request reprint Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: effect modification by sex for carotenoids
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Institute, Nagoya 464 8681, Japan
    Nutr Cancer 51:13-24. 2005
    ..010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits...
  28. ncbi request reprint Systematic review and meta-analysis: importance of CagA status for successful eradication of Helicobacter pylori infection
    T Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Aliment Pharmacol Ther 24:273-80. 2006
    ..Some, but not all studies have provided evidence that the CagA status of Helicobacter pylori strains is a predictive factor for the outcome of eradication therapy...
  29. doi request reprint Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes
    M Naito
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Epidemiol Infect 138:512-8. 2010
    ..016). Our findings suggested that circulating IL-8 levels were associated with H. pylori infection. The effect of H. pylori infection on plasma IL-8 levels was not clearly modified by the IL-8 T-251A polymorphism...
  30. pmc Soybean products and reduction of breast cancer risk: a case-control study in Japan
    K Hirose
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden Chikusa ku, Nagoya 464 8681, Japan
    Br J Cancer 93:15-22. 2005
    ....
  31. ncbi request reprint Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 15:1009-13. 2006
    ..Heavy drinker status was also strongly associated with ADH2 Arg alleles. In conclusion, this study showed the strong effect of ADH2 His(47)Arg polymorphism on habitual drinking regardless of ALDH2 genotype...
  32. ncbi request reprint Trends in site-specific mortality from oral and pharyngeal cancer among Japanese males, 1950-94
    W Z Su
    Department of Oral Surgery, Nagoya University School of Medicine, Japan
    Oral Oncol 35:9-16. 1999
    ..Mortality from cancer of the lip, buccal cavity and pharynx has consistently been increasing in Japanese males from 1950 to 1994, with similar upward mortality trends for some specific sites...
  33. ncbi request reprint Tobacco smoking and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population
    Tetsuya Mizoue
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Jpn J Clin Oncol 36:25-39. 2006
    ..It is unclear whether tobacco smoking is related to colorectal cancer risk in Japan. We evaluated the association among the Japanese population based on a systematic review of epidemiologic evidence...
  34. ncbi request reprint Dietary risk factors for colon and rectal cancers: a comparative case-control study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 16:125-35. 2006
    ..In Japan, the incidence rate of colon cancer has more rapidly increased than that of rectal cancer. The differential secular trends may be due to different dietary factors in the development of colon and rectal cancers...
  35. ncbi request reprint Smoking and colorectal cancer in a non-Western population: a prospective cohort study in Japan
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Epidemiol 13:323-32. 2003
    ..The risk of colorectal cancer in relation to smoking habits has been examined mostly in Caucasians, and evidence for other ethnic groups is still scarce...
  36. ncbi request reprint Applicability of allele/genotype frequency from documented controls for case-control studies on genotypes among Japanese: MTHFR C677T as an example
    Kenta Iida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Asian Pac J Cancer Prev 10:231-6. 2009
    ....
  37. ncbi request reprint The association between tumour necrosis factor-alpha gene polymorphism and the susceptibility to rugal hyperplastic gastritis and gastric carcinoma
    Itaru Ohyama
    Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Gastroenterol Hepatol 16:693-700. 2004
    ..The aim of this study was to clarify the association of tumour necrosis factor-alpha (TNFA) gene polymorphism with susceptibility to hyper-rugosity. We also examined the association of TNFA polymorphism with gastric carcinoma...
  38. ncbi request reprint Risk factors for sudden unexpected death among workers: a nested case-control study in central Japan
    H Kondo
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Prev Med 33:99-107. 2001
    ..CONCLUSION: These findings suggest that periodic medical checkups can help to predict and prevent employee sudden death...
  39. ncbi request reprint Smoking and drinking habits as risk factors for hearing loss in the elderly: epidemiological study of subjects undergoing routine health checks in Aichi, Japan
    A Itoh
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Public Health 115:192-6. 2001
    ..10 (1.53-2.89)), while heavy drinkers did not show an increased risk compared to non-drinkers. Our findings might provide some clues for the primary prevention of age-related hearing loss...
  40. ncbi request reprint Seasonal allergic rhinoconjunctivitis and fatty acid intake: a cross-sectional study in Japan
    K Wakai
    Department of Preventive Medicine/Biostatistics and Medical Decision-Making, Nagoya University Graduate School of Medicine, Japan
    Ann Epidemiol 11:59-64. 2001
    ..CONCLUSIONS: Dietary intake of n-6 polyunsaturated fatty acids was positively associated with seasonal allergic rhinoconjunctivitis in spring...
  41. doi request reprint PRKCH gene polymorphism is associated with the risk of severe gastric atrophy
    Yasuyuki Goto
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, 466 8550, Japan
    Gastric Cancer 13:90-4. 2010
    ..To elucidate its applicability in the development of GA and GC, this study aimed to investigate the associations of the PRKCH polymorphism with the risks of GA and GC...
  42. ncbi request reprint Cigarette smoking and liver cancer risk: an evaluation based on a systematic review of epidemiologic evidence among Japanese
    Keitaro Tanaka
    Department of Preventive Medicine, Saga University, Japan
    Jpn J Clin Oncol 36:445-56. 2006
    ..Emerging epidemiologic data suggest that cigarette smoking may increase the risk of primary liver cancer. We evaluated this association based on a systematic review of epidemiologic evidence among Japanese populations...
  43. ncbi request reprint One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Carcinogenesis 26:2164-71. 2005
    ..In conclusion, we found consistently significant interactions between one-carbon metabolism-related polymorphisms and alcohol drinking...
  44. ncbi request reprint Updated information on risk factors for lung cancer: findings from the JACC Study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan
    J Epidemiol 15:S134-9. 2005
    ..Updated information on risk factors for lung cancer, therefore, is of great importance. The Japan Collaborative Cohort Study, a large prospective study started in 1988, has provided such information...
  45. ncbi request reprint One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:1439-46. 2007
    ..04), MTR A2756G (P = 0.04) and MTRR A66G (P = 0.03) polymorphisms. The results suggest that there may be interactions between one-carbon metabolism-related polymorphisms and alcohol drinking for HNSCC risk...
  46. ncbi request reprint A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Carcinogenesis 27:1018-23. 2006
    ..38, 0.80-2.38). In conclusion, while we failed to find any significant association with the ALDH2 polymorphism itself, significant interaction between ALDH2 and ADH2 polymorphism was observed. Replication in the future study is warranted...
  47. ncbi request reprint Alcohol drinking and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population
    Tetsuya Mizoue
    Department of Preventive Medicine, Kyushu University, Fukuoka, Japan
    Jpn J Clin Oncol 36:582-97. 2006
    ..On the basis of a systematic review of epidemiological evidence, we evaluated this association among the Japanese population, who may be more susceptible to alcohol-related diseases than Western populations...
  48. ncbi request reprint Tobacco smoking and lung cancer risk: an evaluation based on a systematic review of epidemiological evidence among the Japanese population
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Jpn J Clin Oncol 36:309-24. 2006
    ..It would be of value, therefore, to quantify that association in Japan based on a systematic review of epidemiological evidence for the primary prevention of lung cancer...
  49. ncbi request reprint Dietary fiber and risk of colorectal cancer in the Japan collaborative cohort study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 16:668-75. 2007
    ..The role of dietary fiber in the prevention of colorectal cancer seems to remain inconsistent, and further investigations in various populations are warranted. (..
  50. ncbi request reprint Helicobacter pylori seropositivity and the myeloperoxidase G-463A polymorphism in combination with interleukin-1B C-31T in Japanese health checkup examinees
    Nobuyuki Katsuda
    Nagoya Kita Health Center, Nagoya, Japan
    Jpn J Clin Oncol 33:192-7. 2003
    ....
  51. ncbi request reprint Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study)
    Takaaki Kondo
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 20 Daikominami 1 chome, Nagoya, Japan
    Cancer Causes Control 18:229-34. 2007
    ..To determine the relationship of body mass index (BMI) and BMI changes during adulthood to lung cancer mortality in a large-sized Japanese cohort...
  52. ncbi request reprint Triplex polymerase chain reactions with confronting two-pair primers (PCR-CTPP) for NQO1 C609T, GSTM1 and GSTT1 polymorphisms: a convenient genotyping method
    Haruya Kawase
    Nagoya University School of Medicine, Japan
    Asian Pac J Cancer Prev 4:67-70. 2003
    ..This convenient genotyping approach has advantages for application in cancer prevention, especially in the Asian Pacific region...
  53. ncbi request reprint Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Sci 97:760-7. 2006
    ..These findings suggest that dietary antioxidant intake prevents HNSCC in smokers and drinkers...
  54. ncbi request reprint Lifestyle risk factors for intrahepatic stone: findings from a case-control study in an endemic area, Taiwan
    Masato Momiyama
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 23:1075-81. 2008
    ..To examine associations between lifestyle risk factors and intrahepatic stone (IHS), we conducted a case-control study in Taiwan, which has the highest incidence of IHS in the world...
  55. doi request reprint Association between body mass index and the colorectal cancer risk in Japan: pooled analysis of population-based cohort studies in Japan
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Ann Oncol 23:479-90. 2012
    ..Obesity has been recognized as important risk factors for colorectal cancer. However, limited evidence is available on colorectal cancer and body mass index (BMI) in Asian population...
  56. ncbi request reprint A prospective study of body size and colon cancer mortality in Japan: The JACC Study
    K Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Int J Obes Relat Metab Disord 28:551-8. 2004
    ..To determine whether body size measurements are risk factors for colon cancer death among the Japanese...
  57. pmc Influence of smoking and CYP2C19 genotypes on H. pylori eradication success
    T Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan
    Epidemiol Infect 135:171-6. 2007
    ..7%, PM 20.0%), indicating possible interactions with CYP2C19 polymorphisms. Smoking has a greater influence on H. pylori eradication than the CYP2C19 genotype. Interaction between smoking and CYP2C19 should be examined in the future...
  58. ncbi request reprint Effect of familial history and smoking on common cancer risks in Japan
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer 109:2116-23. 2007
    ..The authors further evaluated the effect modification by habitual smoking with adjustment for other confounding environmental factors...
  59. doi request reprint Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 99:1202-8. 2008
    ..023). In conclusion, soy consumption may exert a protective association against the development of NSCLCs with EGFR mutations, providing possible insights into mechanisms of their genesis...
  60. ncbi request reprint Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Cancer 121:377-85. 2007
    ....
  61. ncbi request reprint Genetic polymorphism in the phenobarbital-responsive enhancer module of the UDP-glucuronosyltransferase 1A1 gene and irinotecan toxicity
    Chiyoe Kitagawa
    Department of Medicine, Division of Respiratory Diseases, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Pharmacogenet Genomics 15:35-41. 2005
    ..The determination of T-3279G and UGT1A1*28 genotypes might be clinically useful in predicting severe irinotecan toxicity in cancer patients...
  62. ncbi request reprint Coffee consumption and the risk of endometrial cancer: Evidence from a case-control study of female hormone-related cancers in Japan
    Kaoru Hirose
    Department of Planning and Information, Aichi Prefectural Institute of Public Health, 7 6 Azanagare, Tsujimachi, Kita ku, Nagoya, Japan
    Cancer Sci 98:411-5. 2007
    ..Given the scarcity of studies of coffee intake and endometrial cancer and other hormone-dependent cancer risk, additional investigations are warranted...
  63. ncbi request reprint Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: a case-control study in Japanese nonsmoking women
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 107:139-44. 2003
    ..In contrast, the GSTM1 null genotype posed an increased, although not significant, risk among them. Additional studies are warranted to confirm the ETS-GSTM1 polymorphism interaction suggested in our present study...
  64. doi request reprint Alcohol drinking and liver cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population
    Keitaro Tanaka
    Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan
    Jpn J Clin Oncol 38:816-38. 2008
    ..g. hepatitis C virus infection) and genetic traits (e.g. presence of poor acetaldehyde metabolizers)...
  65. ncbi request reprint Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 15:1791-8. 2006
    ....
  66. ncbi request reprint Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions
    Chun xia Yang
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Asian Pac J Cancer Prev 6:256-62. 2005
    ..Interactions between ALDH2 and ADH2 need further clarification...
  67. ncbi request reprint An intervention study of smoking cessation with feedback on genetic cancer susceptibility in Japan
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusaku Nagoya, Japan
    Prev Med 42:102-8. 2006
    ..To evaluate whether feedback of genetic information regarding an L-myc polymorphism, identified as impacting on tobacco-related cancer risk, has an influence on smoking cessation, an intervention study was conducted...
  68. ncbi request reprint Intake frequency of fish and serum levels of long-chain n-3 fatty acids: a cross-sectional study within the Japan Collaborative Cohort Study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    J Epidemiol 15:211-8. 2005
    ..Whether reported fish consumption reflects the fatty acid intake, however, has to be elucidated...
  69. pmc A study on how a 6-month aerobic exercise program can modify coronary risk factors depending on their severity in middle-aged sedentary women
    Y Lin
    Department of Preventive Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, 466 8550, Showaku, Nagoya, Japan
    Environ Health Prev Med 4:117-21. 1999
    ..We conclude that the 6-month aerobic exercise program would modify women's coronary risk factors depending on their initial values, probably independently of the changes in physical fitness...
  70. pmc Prognostic value of performance status assessed by patients themselves, nurses, and oncologists in advanced non-small cell lung cancer
    M Ando
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Cancer 85:1634-9. 2001
    ..These results showed that the assessment by the patients themselves is different from those by the nurses and the oncologists and provided additional support for the use of the assessment by oncologists in clinical oncology...
  71. ncbi request reprint Maternal serum placental leucine aminopeptidase (P-LAP)/oxytocinase and preterm delivery
    H Kozaki
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
    Int J Gynaecol Obstet 73:207-13. 2001
    ..CONCLUSION: Maternal serum P-LAP activity decreases in cases with spontaneous preterm delivery and may be a clinically potential marker for some cases of preterm labor...
  72. ncbi request reprint Multivariate evaluation of factors affecting recurrence, progression, and survival in patients with superficial bladder cancer treated with intravesical bacillus Calmette-Guérin (Tokyo 172 strain) therapy: significance of concomitant carcinoma in situ
    M Takashi
    Department of Urology, Nagoya University Graduate School of Medicine, Japan
    Int Urol Nephrol 33:41-7. 2002
    ..The present findings suggest that careful follow-up is mandatory after BCG instillation therapy for patients with superficial bladder cancer and concomitant CIS because of their relatively poor prognosis...
  73. doi request reprint Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    Helicobacter 14:47-53. 2009
    ..We investigated the associations of TLR4+3725 G/C polymorphism, another functional polymorphism of TLR4, with risk of gastric cancer and gastric atrophy in Japanese...
  74. ncbi request reprint A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Sci 95:602-7. 2004
    ....
  75. ncbi request reprint A prospective study on the possible association between having children and colon cancer risk: findings from the JACC Study
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Sci 95:243-7. 2004
    ..From these prospective data, having children may reduce risk of colon cancer among women, but not among men, suggesting that modifications of hormone profiles secondary to pregnancies may influence female colon cancer risk...
  76. ncbi request reprint Trends in asthma mortality in Japan
    Yuko Ito
    Second Department of Internal Medicine, Nagoya University School of Medicine, 6 Japan
    J Asthma 39:633-9. 2002
    ..The high fatality rate stemming from the overuse of beta 2-agonists may account for the mortality increase...
  77. ncbi request reprint Attributable and absolute risk of lung cancer death by smoking status: findings from the Japan Collaborative Cohort Study
    Masahiko Ando
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 105:249-54. 2003
    ..For all current smokers, immediate cessation is encouraged because it offers the only realistic way to avoid a substantial increase in lung cancer mortality brought about by further continuation of smoking...
  78. doi request reprint Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Gastroenterol 44:1165-71. 2009
    ..pylori seropositivity and gastric atrophy in Japanese people...
  79. ncbi request reprint Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study
    Kazuko Nishio
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Causes Control 18:801-8. 2007
    ..To examine whether soy foods really have protective effects against breast cancer and how their influence on breast cancer is modified according to menopausal status, we conducted a population-based, prospective cohort study in Japan...
  80. ncbi request reprint Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake
    Kazuko Nishio
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Epidemiol 18:125-31. 2008
    ..Since studies considering folate intake are limited, we examined the association between folate intake and serum folate levels, according to the genotype...
  81. ncbi request reprint Foods and beverages in relation to urothelial cancer: case-control study in Japan
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Urol 11:11-9. 2004
    ..The roles of several foods and beverages in the development of bladder cancer remain unclear...
  82. ncbi request reprint Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya 464 8681, Japan
    Cancer Sci 96:590-9. 2005
    ..05-4.13). This prospective study did not support any increase in the risk of breast cancer associated with total or saturated fat intake, but it suggested the protective effects of the long-chain n-3 fatty acids that are abundant in fish...
  83. ncbi request reprint Alcohol consumption and colorectal cancer risk: findings from the JACC Study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 15:S173-9. 2005
    ..Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995...
  84. ncbi request reprint Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism
    Rieko Okada
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Mol Med Report 1:595-8. 2008
    ..039; HDL-C, p=0.020). These data suggest that cigarette smoking might alter the metabolism of cholesterol in Japanese PTPN11 AA genotype carriers...
  85. ncbi request reprint A past history of gastric ulcers and Helicobacter pylori infection increase the risk of gastric malignant lymphoma
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 27:1391-7. 2006
    ..These results suggested the risk of gastric lymphoma increased by interaction between H. pylori infection and gastric ulcer history. Further studies are warranted...
  86. ncbi request reprint Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 98:96-101. 2007
    ..In conclusion, our case-control study clearly demonstrated that the impacts of smoking and sex on the risk of EGFRmut NSCLC are different from those for EGFRwt NSCLC. Further epidemiological evaluation is warranted...
  87. ncbi request reprint Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 68:454-61. 2005
    ..To elucidate whether leptin is involved in the etiology of female colorectal cancer...
  88. doi request reprint Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Dig Dis Sci 56:1131-7. 2011
    ..A G/C polymorphism in miRNA-146a (rs2910164) was shown to be associated with the risk of hepatocellular carcinoma...
  89. ncbi request reprint Smoking behavior and risk of Helicobacter pylori infection, gastric atrophy and gastric cancer in Japanese
    Asahi Hishida
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Asian Pac J Cancer Prev 11:669-73. 2010
    ..This study revealed that smoking behavior contributed to the increased risk of gastric carcinogenesis from gastric atrophy, and had little influence on H. pylori infection or gastric atrophy development...
  90. ncbi request reprint Impact of menstrual and reproductive factors on breast cancer risk in Japan: results of the JACC study
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550
    Cancer Sci 96:57-62. 2005
    ....
  91. ncbi request reprint The number of metabolic syndrome components is a good risk indicator for both early- and late-stage kidney damage
    R Okada
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan Electronic address
    Nutr Metab Cardiovasc Dis 24:277-85. 2014
    ..This study investigated the associations of renal hyperfiltration and hypofiltration with the number of metabolic syndrome (MetS) components...
  92. ncbi request reprint A comparison of ovarian metastasis between squamous cell carcinoma and adenocarcinoma of the uterine cervix
    T Nakanishi
    Department of Gynecology, Aichi Cancer Center Hospital, Nagoya, Japan
    Gynecol Oncol 82:504-9. 2001
    ..The results thus suggested that the differences in ovarian metastases were caused by the different characteristics of the two types of carcinoma...
  93. ncbi request reprint Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan
    Chun xia Yang
    Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, China
    Carcinogenesis 26:1285-90. 2005
    ..31 (95% CI, 0.10-0.94), indicating risk with heavy drinking to be 69% decreased in individuals harboring the 677TT genotype. We failed to find any significant interaction between either of the polymorphisms and smoking...
  94. ncbi request reprint Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
    Yingsong Lin
    Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan
    J Epidemiol 18:77-83. 2008
    ..We examined the association between breast cancer incidence and active and passive smoking in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk...
  95. ncbi request reprint Associations of lifestyle factors with bone mineral density among male university students in Japan
    Isuzu Egami
    Department of Food and Nutrition, Nagoya Bunri College, Nagoya Japan
    J Epidemiol 13:48-55. 2003
    ..Single-life students had lower bone mineral density compared with those lived with families (p=0.044). Bone mineral density could be increased by modifying dietary habits in young men...
  96. ncbi request reprint Comparison of lifestyle risk factors by family history for gastric, breast, lung and colorectal cancer
    Xin En Huang
    Department of Chemotherapy, Jiangsu Cancer Hospital and Research Institute, Nanjing 210009, China
    Asian Pac J Cancer Prev 5:419-27. 2004
    ..Habitual smoking increased, while frequent physical exercise and raw vegetables intake decreased cancer risk, regardless of the CFH status...
  97. ncbi request reprint Dietary habits and risk of urothelial cancer death in a large-scale cohort study (JACC Study) in Japan
    Fumio Sakauchi
    Department of Public Health, Sapporo Medical University School of Medicine, Japan
    Nutr Cancer 50:33-9. 2004
    ..It was suggested that urothelial cancer death could be potentially preventable by smoking cessation and regular intake of milk and fruit...
  98. ncbi request reprint Perceived psychologic stress and colorectal cancer mortality: findings from the Japan Collaborative Cohort Study
    Masayo Kojima
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Psychosom Med 67:72-7. 2005
    ..The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study...
  99. ncbi request reprint Reproducibility and validity of a self-administered food frequency questionnaire used in the JACC study
    Chigusa Date
    Department of Nutrition and Food Sciences, Faculty of Human Environmental Sciences, Mukogawa Women s University, Japan
    J Epidemiol 15:S9-23. 2005
    ..Although more than 110 thousand subjects enrolled in JACC Study and responded to the FFQ, no validation study has been conducted to date...
  100. ncbi request reprint Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study
    Yoshinori Ito
    Department of Public Health, Fujita Health University School of Health Sciences, Japan
    J Epidemiol 15:S140-9. 2005
    ..To examine the association by sex, we extended the follow-up and analyzed additional serum samples...