H Umegaki

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc Factors associated with cognitive decline in elderly diabetics
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Dement Geriatr Cogn Disord Extra 1:1-9. 2011
  2. ncbi request reprint The response of the autonomic nervous system to the cholinesterase inhibitor, donepezil
    Hiroyuki Umegaki
    Department of Geriatrics Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuro Endocrinol Lett 34:383-7. 2013
  3. ncbi request reprint Burden reduction of caregivers for users of care services provided by the public long-term care insurance system in Japan
    Hiroyuki Umegaki
    Nagoya University Graduate School of Medicine, Department of Community Healthcare and Geriatrics, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan Electronic address
    Arch Gerontol Geriatr 58:130-3. 2014
  4. ncbi request reprint The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system
    Oyun Khookhor
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuro Endocrinol Lett 34:58-61. 2013
  5. ncbi request reprint Neurocognitive dysfunction in old diabetes: management and treatment
    Hiroyuki Umegaki
    Department Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Adv Exp Med Biol 771:465-70. 2012
  6. doi request reprint Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Geriatr Gerontol Int 13:28-34. 2013
  7. doi request reprint Cognitive impairments and functional declines in older adults at high risk for care needs
    Hiroyuki Umegaki
    Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Geriatr Gerontol Int 13:77-82. 2013
  8. doi request reprint Risk factors associated with cognitive decline in the elderly with type 2 diabetes: baseline data analysis of the Japanese Elderly Diabetes Intervention Trial
    Hiroyuki Umegaki
    Department of Community Healthcare and Geriatrics, Graduate School of Medicine, University of Nagoya, Nagoya, Aichi, Japan
    Geriatr Gerontol Int 12:103-9. 2012
  9. doi request reprint Risk factors associated with cognitive decline in the elderly with type 2 diabetes: pooled logistic analysis of a 6-year observation in the Japanese Elderly Diabetes Intervention Trial
    Hiroyuki Umegaki
    Department of Community Healthcare and Geriatrics, Graduate School of Medicine, University of Nagoya, Nagoya, Aichi, Japan
    Geriatr Gerontol Int 12:110-6. 2012
  10. doi request reprint Neurodegeneration in diabetes mellitus
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Adv Exp Med Biol 724:258-65. 2012

Collaborators

Detail Information

Publications74

  1. pmc Factors associated with cognitive decline in elderly diabetics
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Dement Geriatr Cogn Disord Extra 1:1-9. 2011
    ....
  2. ncbi request reprint The response of the autonomic nervous system to the cholinesterase inhibitor, donepezil
    Hiroyuki Umegaki
    Department of Geriatrics Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuro Endocrinol Lett 34:383-7. 2013
    ..The effects of the administration of ChEIs on the autonomic nervous system, however, are complex and controversial...
  3. ncbi request reprint Burden reduction of caregivers for users of care services provided by the public long-term care insurance system in Japan
    Hiroyuki Umegaki
    Nagoya University Graduate School of Medicine, Department of Community Healthcare and Geriatrics, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan Electronic address
    Arch Gerontol Geriatr 58:130-3. 2014
    ..In Japanese LTCI, the overall satisfaction of the caregivers appears to be relatively high and is associated with the reduction of the care burden. ..
  4. ncbi request reprint The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system
    Oyun Khookhor
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuro Endocrinol Lett 34:58-61. 2013
    ..In the current study we tried to measure the effects of neostigmine injection into the hippocampus using the non-invasive measure of heart rate variability (HRV)...
  5. ncbi request reprint Neurocognitive dysfunction in old diabetes: management and treatment
    Hiroyuki Umegaki
    Department Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Adv Exp Med Biol 771:465-70. 2012
    ..Considering the progressive aging world-wide, more research to investigate the association between T2DM and dementia process, as well as the best way to manage this population, will be important...
  6. doi request reprint Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Geriatr Gerontol Int 13:28-34. 2013
    ..Exercise is a helpful non-pharmacological therapy. Considering the progressive aging of the worldwide population, more research to investigate the best way to manage this population is important...
  7. doi request reprint Cognitive impairments and functional declines in older adults at high risk for care needs
    Hiroyuki Umegaki
    Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Geriatr Gerontol Int 13:77-82. 2013
    ....
  8. doi request reprint Risk factors associated with cognitive decline in the elderly with type 2 diabetes: baseline data analysis of the Japanese Elderly Diabetes Intervention Trial
    Hiroyuki Umegaki
    Department of Community Healthcare and Geriatrics, Graduate School of Medicine, University of Nagoya, Nagoya, Aichi, Japan
    Geriatr Gerontol Int 12:103-9. 2012
    ..In the current study, we attempted to elucidate the association of clinical indices and diabetic complications at baseline with cognitive declines after 6-year follow up in type 2 diabetic elderly...
  9. doi request reprint Risk factors associated with cognitive decline in the elderly with type 2 diabetes: pooled logistic analysis of a 6-year observation in the Japanese Elderly Diabetes Intervention Trial
    Hiroyuki Umegaki
    Department of Community Healthcare and Geriatrics, Graduate School of Medicine, University of Nagoya, Nagoya, Aichi, Japan
    Geriatr Gerontol Int 12:110-6. 2012
    ..In the current study, we tried to identify the associated factors with cognitive decline during a 6-year period in elderly T2DM considering the changes in the clinical indices during the follow-up period...
  10. doi request reprint Neurodegeneration in diabetes mellitus
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Adv Exp Med Biol 724:258-65. 2012
    ..More research to elucidate the mechanism of neurodegeneration associated with T2DM is warranted...
  11. pmc Effects of a low-carbohydrate diet on glycemic control in outpatients with severe type 2 diabetes
    Hajime Haimoto
    Department of Internal Medicine, Haimoto Clinic, 1 80 Yayoi, Kasugai, Aichi 486 0838, Japan
    Nutr Metab (Lond) 6:21. 2009
    ..The effectiveness of the diet may be comparable to that of insulin therapy...
  12. pmc Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet: a crossover meal tolerance study
    Hajime Haimoto
    Department of Internal Medicine, Haimoto Clinic, 1 80 Yayoi, Kasugai, Aichi 486 0838, Japan
    Nutr Metab (Lond) 6:52. 2009
    ..With respect to energy metabolism, acute metabolic responses to high-carbohydrate meals (HCMs) have not been determined in LCD patients with T2DM...
  13. ncbi request reprint Attitudes toward disclosing the diagnosis of dementia in Japan
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Int Psychogeriatr 19:253-65. 2007
    ..The purpose of the present study was to investigate the attitudes of people in a large city in Japan toward the disclosure of a diagnosis of dementia...
  14. doi request reprint Discontinuation of donepezil for the treatment of Alzheimer's disease in geriatric practice
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Int Psychogeriatr 20:800-6. 2008
    ..In the current study we surveyed the discontinuation of donepezil, a cholinesterase inhibitor, for the treatment of Alzheimer's disease in a Japanese geriatric outpatient clinic in a university hospital...
  15. doi request reprint Association of higher carbohydrate intake with depressive mood in elderly diabetic women
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Nutr Neurosci 12:267-71. 2009
    ..In the current study, the association of the carbohydrate energy/total energy (C/E ratio) and other factors with depressive mood in the diabetic elderly were investigated...
  16. doi request reprint Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration?
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Aichi, Japan
    Age Ageing 39:8-10. 2010
    ..It remains to be investigated whether medical interventions on vascular risk factors have protective effects against the development and progress of dementia...
  17. ncbi request reprint Stimulation of the hippocampal glutamate receptor systems induces stress-like responses
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466 8550, Japan
    Neuro Endocrinol Lett 27:339-43. 2006
    ..We also studied the interactions between glutamate and acetylcholine in this response in the hippocampus...
  18. doi request reprint Glucose control levels, ischaemic brain lesions, and hyperinsulinaemia were associated with cognitive dysfunction in diabetic elderly
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, Japan
    Age Ageing 37:458-61. 2008
  19. ncbi request reprint Factors associated with lower Mini Mental State Examination scores in elderly Japanese diabetes mellitus patients
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Neurobiol Aging 29:1022-6. 2008
    ..139; 95% CI=1.045-1.243), serum albumin (OR=0.336; 95% CI=0.174-0.745), and history of cerebrovascular disease (OR=3.011; 95% CI=1.578-5.748) were the variables significantly associated with having lower MMSE scores...
  20. pmc Aging of the striatum: mechanisms and interventions
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, Japan
    Age (Dordr) 30:251-61. 2008
    ..These achievements confirm that an age-associated decrease of D(2)R contributes functional alteration of the interaction of DA and ACh in the striatum and demonstrate that these age-associated changes indeed are modifiable...
  21. doi request reprint Association of lower hemoglobin level with depressive mood in elderly women at high risk of requiring care
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466 8550, Japan
    Geriatr Gerontol Int 11:262-6. 2011
    ..In the current study, we analyzed the association of hemoglobin level and depressive mood in a group of community-dwelling elderly at high risk of requiring care...
  22. doi request reprint Clinical results and issues of acute myeloid leukemia in elderly patients aged 75 years and older
    Shine Abe
    Department of Geriatric Medicine, Hachioji Medical Center, Tokyo, Japan
    Geriatr Gerontol Int 11:290-6. 2011
    ..In addition, we aimed to elucidate the situation of patients with AML accompanied by dementia, which has been largely ignored in previous studies...
  23. ncbi request reprint Microdialysis measurement of acetylcholine in rat hippocampus during severe insulin-induced hypoglycemia
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Neuro Endocrinol Lett 27:128-32. 2006
    ..It has been well acknowledged that hypoglycemia induces cognitive impairment. However, the behavior of hippocampal cholinergic system, which is thought to play a key role in cognition, during hypoglycemia remains to be elucidated...
  24. ncbi request reprint Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study
    H Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Neuroscience 121:479-86. 2003
    ....
  25. ncbi request reprint Involvement of the entorhinal cortex in the stress response to immobilization, but not to insulin-induced hypoglycaemia
    H Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Aichi, Japan
    J Neuroendocrinol 15:237-41. 2003
    ..Together, these results indicate that the entorhinal cortex is closely involved in the stress response to immobilization but not to insulin-induced hypoglycaemia...
  26. doi request reprint Responses of hypothalamo-pituitary-adrenal axis to a cholinesterase inhibitor
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Aichi, Japan
    Neuroreport 20:1366-70. 2009
    ..The increase in adrenocorticotropic hormone and loss of appetite after oral administration of the drug were attenuated after daily administration for 2 weeks...
  27. ncbi request reprint Low plasma epinephrine in elderly female subjects of dementia of Alzheimer type
    H Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    Brain Res 858:67-70. 2000
    ..Other values did not differ significantly among the groups...
  28. ncbi request reprint The elevation of plasma adrenocorticotrophic hormone and expression of c-Fos in hypothalamic paraventricular nucleus by microinjection of neostigmine into the hippocampus in rats: comparison with acute stress responses
    W Zhu
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, 466 8550, Aichi, Japan
    Brain Res 892:391-5. 2001
    ..Taken together, the results of this study indicate that microinjection of neostigmine into the hippocampus is a potential experimental model for acute stress responses...
  29. ncbi request reprint Involvement of the bed nucleus of the stria terminalis in hippocampal cholinergic system-mediated activation of the hypothalamo--pituitary--adrenocortical axis in rats
    W Zhu
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan
    Brain Res 916:101-6. 2001
    ..The results of this study indicate that the BNST relays signals of hippocampal cholinergic system-mediated activation of the HPA axis in rats...
  30. ncbi request reprint Involvement of dopamine D(2) receptors in complex maze learning and acetylcholine release in ventral hippocampus of rats
    H Umegaki
    Department of Geriatrics, University of Nagoya Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, 466 8550, Japan
    Neuroscience 103:27-33. 2001
    ..Taken together, we suggest that D(2) receptors in the ventral hippocampus are involved in memory performance, possibly through the regulation of acetylcholine...
  31. ncbi request reprint Dietary restriction of choline reduces hippocampal acetylcholine release in rats: in vivo microdialysis study
    A Nakamura
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain Res Bull 56:593-7. 2001
    ..The vulnerability of the mechanism in the hippocampus to dietary choline restriction is indicated by impaired mnemonic performance we observed...
  32. ncbi request reprint Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study
    H Umegaki
    Department of Geriatrics, Nagoya University, Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, 466 8550, Aichi, Japan
    Brain Res 881:241-3. 2000
    ..In AD subjects in relatively early stages of the disease [Mini-Mental State Examination (MMSE)], at baseline, high plasma cortisol led to rapid declines in MMSE scores over a 40-month period...
  33. ncbi request reprint The metabolism of plasma glucose and catecholamines in Alzheimer's disease
    H Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Aichi, 466 8550, Nagoya, Japan
    Exp Gerontol 35:1373-82. 2000
    ..Measurement of plasma catecholamines during a fasting state in the groups of AD subjects, vascular dementia subjects, and non-demented control subjects showed significantly lower plasma epinephrine levels in the AD subjects...
  34. ncbi request reprint The relationship between functional disability and depressive mood in Japanese older adult inpatients
    Joji Onishi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    J Geriatr Psychiatry Neurol 17:93-8. 2004
    ..The results reveal that factor analysis of GDS-15 will help in understanding the etiology of depressive mood, thereby contributing to better therapeutic approaches...
  35. ncbi request reprint Functional recovery of the striatal cholinergic system in aged rats by adenoviral vector-mediated gene transfer of dopamine D2 receptor
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Mech Ageing Dev 127:813-5. 2006
    ..The current study suggests that age-associated functional decline with decreased gene expression of the receptor may be restored by intervention...
  36. ncbi request reprint [Cognitive function and brain atrophy in elderly type 2 diabetic patients in comparison with non-diabetic elderly subjects]
    N Mogi
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nippon Ronen Igakkai Zasshi 38:388-92. 2001
    ..035). The drug-treated diabetics subjects had wider temporal horn tips on the right side than did the diet treated diabetics and nondiabetic subjects (Fisher's post hoc test, P = 0.030, P = 0.016)...
  37. ncbi request reprint [Target of glycemic control of elderly diabetes mellitus patients]
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Rinsho 64:70-3. 2006
    ..Because the risks of hypoglycemia, and/or drug-drug interactions are higher in the older patients, the medical providers must balance benefits and risks for every patient. RCT in older diabetes mellitus patients would be required...
  38. ncbi request reprint Dopamine D2 receptor plays a role in memory function: implications of dopamine-acetylcholine interaction in the ventral hippocampus
    Hiroshige Fujishiro
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Nagoya, Aichi, 466 8550, Japan
    Psychopharmacology (Berl) 182:253-61. 2005
    ..The role of the hippocampal dopaminergic system in mnemonic function has not been clarified yet...
  39. ncbi request reprint Effects of educational background on verbal fluency task performance in older adults with Alzheimer's disease and mild cognitive impairment
    Naoko Kawano
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya shi, Japan
    Int Psychogeriatr 22:995-1002. 2010
    ..In order to examine the utility of the VFT as a tool for screening for AD, it is necessary to study the effect of education not only in the cognitively intact population but also in the population of early AD patients...
  40. ncbi request reprint Importance of lipid levels in elderly diabetic individuals: baseline characteristics and 1-year survey of cardiovascular events
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Circ J 72:218-25. 2008
    ..Complications of dyslipidemia increase the risk, but direct evidence is limited, so a cohort prospective study (Japan-CDM) was conducted...
  41. pmc Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes Care 32:1221-3. 2009
    ..To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals...
  42. ncbi request reprint In vivo assessment of adenoviral vector-mediated gene expression of dopamine D(2) receptors in the rat striatum by positron emission tomography
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550 Japan
    Synapse 43:195-200. 2002
    ..The results of the current study demonstrate that PET can be used for longitudinal in vivo assessment of D(2)R expression mediated by adenoviral vector in rat brain...
  43. ncbi request reprint Influence of behavioral and psychological symptoms of dementia (BPSD) and environment of care on caregivers' burden
    Joji Onishi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Arch Gerontol Geriatr 41:159-68. 2005
    ..The model indicates that the caregiver's burden can be affected not merely by the illness of the care recipients but by the caregiver's background and the care environment...
  44. ncbi request reprint Behavioral, psychological and physical symptoms in group homes for older adults with dementia
    Joji Onishi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Int Psychogeriatr 18:75-86. 2006
    ....
  45. ncbi request reprint Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies
    Hiroshige Fujishiro
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Acta Neuropathol 111:109-14. 2006
    ....
  46. ncbi request reprint A comparison of depressive mood of older adults in a community, nursing homes, and a geriatric hospital: factor analysis of Geriatric Depression Scale
    Joji Onishi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Geriatr Psychiatry Neurol 19:26-31. 2006
    ..The results indicate an extended utility of the GDS-15 for a deeper understanding of depressive mood in various care settings...
  47. ncbi request reprint The clock drawing test as a valid screening method for mild cognitive impairment
    Sayaka Yamamoto
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Dement Geriatr Cogn Disord 18:172-9. 2004
    ..7%) and specificity (75.6%), than were the other protocols. The CDT, as a handy screening method, may be useful for clinicians to reliably identify subjects with MCI, and it may contribute to early detection of dementia...
  48. ncbi request reprint Which two questions of Mini-Mental State Examination (MMSE) should we start from?
    Joji Onishi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Arch Gerontol Geriatr 44:43-8. 2007
    ..2% and a specificity of 69.2% if cut-off was set at 7/7+. This finding appears to help streamline the screening process for cognitive impairment in general elderly population...
  49. ncbi request reprint Different glial reactions to hippocampal stab wounds in young adult and aged rats
    Waner Zhu
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Japan
    J Gerontol A Biol Sci Med Sci 58:117-22. 2003
    ..We conclude that different glial reactivity in the aged brain suggests that aging is associated with increased glial responsiveness that may enhance susceptibility to injury and disease in the brain...
  50. ncbi request reprint The age-associated changes of dopamine-acetylcholine interaction in the striatum
    Shinobu Kurotani
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Exp Gerontol 38:1009-13. 2003
    ..1 microM and that of the young rats at the dose of 1 microM. The current study suggested that the striatal DA-ACh interaction was affected by the aging process...
  51. ncbi request reprint [Relation between destination on discharge in the elderly patients and comprehensive geriatric assessment at admission in the ward of the Geriatric Department of University Hospital]
    Hiroyuki Umegaki
    Nagoya University Graduate School of Medicine, Department of Geriatrics
    Nihon Ronen Igakkai Zasshi 39:75-82. 2002
    ..In multiple logistic regression models, it was suggested that activity of daily living, specifically independence of excretion, and ability in communication were significantly related to the destination on discharge...
  52. ncbi request reprint Cognitive function in Japanese elderly with type 2 diabetes mellitus
    Nanaka Mogi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    J Diabetes Complications 18:42-6. 2004
    ..05) and nondiabetic subjects (P<.01). Our study suggests that Japanese elderly DM subjects, especially those with insulin treatment, have poor cognitive function...
  53. ncbi request reprint [The delayed word recall task using ADAS-Jcog word booklet effectively divides patients with mild cognitive impairment from normal elderly people]
    Naoko Kawano
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nihon Ronen Igakkai Zasshi 44:490-6. 2007
    ....
  54. ncbi request reprint Smell identification test as an indicator for cognitive impairment in Alzheimer's disease
    Y Suzuki
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Int J Geriatr Psychiatry 19:727-33. 2004
    ..The aim of the present study was to assess olfactory dysfunction in patients with Alzheimer's disease (AD) and to compare utility of the olfactory tests as possible clinical markers...
  55. ncbi request reprint [Clinical global assessment]
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Rinsho 62:42-4. 2004
  56. ncbi request reprint [Awareness of dementia in older adults attending dementia-prevention programs in community healthcare centers]
    Hiroshige Fujishiro
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 42:340-5. 2005
    ..Overall, the results of the questionnaire suggest that appropriate education of dementia to older adults may contribute to early diagnosis of the community level, thereby may maximize the effect of therapeutic interventions...
  57. ncbi request reprint [Attitudes of Japanese general practitioners towards referrals of patients with dementia]
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 44:102-6. 2007
    ..In the current study we conducted a survey regarding the attitudes towards referrals between general practitioners and specialists by sending a questionnaire to 1,176 general practitioners...
  58. ncbi request reprint [An overview and prospect of demented outpatient care in a department of geriatric medicine: report based on statistical review of the memory clinic at the geriatric outpatient unit of the Nagoya University Hospital]
    Naoko Kawano
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 44:611-8. 2007
    ..This study aimed to review the status of the memory clinic at the geriatric outpatient unit of a university hospital and also to compare the results with other reports...
  59. ncbi request reprint [Impact of driving cessation on daily transportation utility in elderly people with cognitive decline: a survey of patients in the memory clinic of an urban university hospital]
    Naoko Kawano
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 46:420-7. 2009
    ..In the present study our goal was to explore the impact of driving cessation on daily transportation utility in older people with cognitive decline...
  60. ncbi request reprint [An elderly case with sarcoidosis whose symptom of dementia was effectively treated by steroid]
    Michiteru Kodama
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 39:648-53. 2002
    ..According to previous reports, elderly sarcoidosis patients relatively rare by show dementia, but sarcoidosis should be considered in the differential diagnosis because steroid treatment can be effective...
  61. ncbi request reprint Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum: comparison of [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, 172 0022, Tokyo, Japan
    Nucl Med Biol 29:307-16. 2002
    ..PET has the limited potential for evaluating the receptor degeneration in the present animal model...
  62. ncbi request reprint Long-term effects of a diet loosely restricting carbohydrates on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes: a 2-year follow-up study
    Hajime Haimoto
    Haimoto Clinic, 1 80 Yayoicho, Kasugai, Aichi 486 0838, Japan
    Diabetes Res Clin Pract 79:350-6. 2008
    ..8+/-3.5, P<0.001). The doses of sulfonylureas clearly tapered, and serum cholesterol profiles improved significantly with the CARD. Our results warrant a long-term and large-scale randomized study of the diet for type 2 diabetes...
  63. ncbi request reprint Factors associated with cognitive impairment in elderly patients with diabetes mellitus
    Mari Suzuki
    J Am Geriatr Soc 54:558-9. 2006
  64. ncbi request reprint [Treatment and care for people with dementia in hospital or institution--critical pass for dementia]
    Hidetoshi Endo
    Department of Geriatrics, Chubu National Hospital
    Nihon Rinsho 62:312-6. 2004
  65. ncbi request reprint [Prevention of dementia]
    Hiroyuki Umegaki
    Nihon Ronen Igakkai Zasshi 43:87-8. 2006
  66. pmc D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats
    Panayotis K Thanos
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 62:481-6. 2008
    ..Thus strategies aimed at increasing D2R expression in NAc may be beneficial in treating cocaine abuse and addiction...
  67. doi request reprint Visceral fat contribution of insulin resistance in elderly people
    Hiroyuki Umegaki
    J Am Geriatr Soc 56:1373-5. 2008
  68. ncbi request reprint Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J-EDIT)
    Taichi Akisaki
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes Metab Res Rev 22:376-84. 2006
    ..The aim of this study was to explore, by means of magnetic resonance (MR) imaging, possible relationships among clinical profiles of diabetes, cognitive function, white matter hyperintensities (WMHs) and subcortical brain atrophy...
  69. ncbi request reprint The entorhinal cortex regulates blood glucose level in response to microinjection of neostigmine into the hippocampus
    Shadi Adeli-Rankouhi
    Department of Geriatrics, Nagoya University Graduate School of Medicine in Japan
    Neuro Endocrinol Lett 26:225-30. 2005
    ..The current study was designed to examine the role of the entorhinal cortex in regulation of blood glucose elevation induced by hippocampal neostigmine injection...
  70. ncbi request reprint DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking
    Panayotis K Thanos
    Department of Medicine, Brookhaven National Laboratory, Upton, New York, USA
    Alcohol Clin Exp Res 28:720-8. 2004
    ..This overexpression of DRD2 reduced alcohol consumption in a two-bottle-choice paradigm and supported the view that high levels of DRD2 may be protective against alcohol abuse...
  71. ncbi request reprint Effect of the entorhinal cortex on diurnal ACTH and corticosterone release in rats
    Waner Zhu
    Department of Medical Psychology, Zhejiang University Graduate School of Medicine, Hangzhou, China
    Neuro Endocrinol Lett 29:159-62. 2008
    ..The aim of the present study was to investigate whether the entorhinal cortex exerts a modulatory effect on circadian ACTH and corticosterone release...
  72. ncbi request reprint [Present status of geriatric care in the world]
    Hidetoshi Endo
    Nihon Naika Gakkai Zasshi 93:2599-602. 2004
  73. ncbi request reprint Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking
    Panayotis K Thanos
    Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Life Sci 77:130-9. 2005
    ..Significant deviations in D2R levels from this range could impact alcohol consumption, and could help to explain possible individual variations in alcohol response, metabolism, sensitivity and consumption...