K Uchida

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Induction of glutathione S-transferase by prostaglandins
    K Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, 464 8601, Nagoya, Japan
    Mech Ageing Dev 116:135-40. 2000
  2. ncbi request reprint Cellular response to bioactive lipid peroxidation products
    K Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Free Radic Res 33:731-7. 2000
  3. ncbi request reprint Lipid peroxidation and redox-sensitive signaling pathways
    Koji Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Curr Atheroscler Rep 9:216-21. 2007
  4. ncbi request reprint A lipid-derived endogenous inducer of COX-2: a bridge between inflammation and oxidative stress
    Koji Uchida
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Mol Cells 25:347-51. 2008
  5. ncbi request reprint Role of reactive aldehyde in cardiovascular diseases
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya, Japan
    Free Radic Biol Med 28:1685-96. 2000
  6. ncbi request reprint Histidine and lysine as targets of oxidative modification
    K Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Amino Acids 25:249-57. 2003
  7. ncbi request reprint 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
    Koji Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University 464 8601, Nagoya, Japan
    Prog Lipid Res 42:318-43. 2003
  8. ncbi request reprint Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 274:2234-42. 1999
  9. ncbi request reprint Lipofuscin-like fluorophores originated from malondialdehyde
    Koji Uchida
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Free Radic Res 40:1335-8. 2006
  10. pmc Protein-bound acrolein: potential markers for oxidative stress
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 95:4882-7. 1998

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint Induction of glutathione S-transferase by prostaglandins
    K Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, 464 8601, Nagoya, Japan
    Mech Ageing Dev 116:135-40. 2000
    ..The molecular mechanism underlying the 15d-PGJ(2)-induced GST expression has been elucidated...
  2. ncbi request reprint Cellular response to bioactive lipid peroxidation products
    K Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Free Radic Res 33:731-7. 2000
    ..These findings argue that lipid mediators could induce a cellular process that represents a cellular defense program against toxic compounds...
  3. ncbi request reprint Lipid peroxidation and redox-sensitive signaling pathways
    Koji Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Curr Atheroscler Rep 9:216-21. 2007
    ....
  4. ncbi request reprint A lipid-derived endogenous inducer of COX-2: a bridge between inflammation and oxidative stress
    Koji Uchida
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Mol Cells 25:347-51. 2008
    ..Here I review current understanding of the mechanisms by which HNE in cooperation with the serum component activates gene expression of COX-2...
  5. ncbi request reprint Role of reactive aldehyde in cardiovascular diseases
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya, Japan
    Free Radic Biol Med 28:1685-96. 2000
    ....
  6. ncbi request reprint Histidine and lysine as targets of oxidative modification
    K Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Amino Acids 25:249-57. 2003
    ..Covalent binding of reactive aldehydes to histidine and lysine is associated with the appearance of carbonyl reactivity and antigenecity of proteins...
  7. ncbi request reprint 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
    Koji Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University 464 8601, Nagoya, Japan
    Prog Lipid Res 42:318-43. 2003
    ..In the present review, I provide a comprehensive summary of HNE, as the product and mediator or oxidative stress...
  8. ncbi request reprint Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 274:2234-42. 1999
    ....
  9. ncbi request reprint Lipofuscin-like fluorophores originated from malondialdehyde
    Koji Uchida
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Free Radic Res 40:1335-8. 2006
    ..These pigments are observed within granules composed, in part, of damaged protein and lipid. In the present mini-review, I provide a comprehensive summary of fluorescent adducts originated from malondialdehyde (MDA)...
  10. pmc Protein-bound acrolein: potential markers for oxidative stress
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 95:4882-7. 1998
    ..These data suggest that the protein-bound acrolein represents potential markers of oxidative stress and long-term damage to protein in aging, atherosclerosis, and diabetes...
  11. ncbi request reprint Future of toxicology--lipid peroxidation in the future: from biomarker to etiology
    Koji Uchida
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Chem Res Toxicol 20:3-5. 2007
    ..This may be a matter of primary concern, which represents an important direction to pursue in the future of toxicology. My latest approach from autoimmune response induced by lipid peroxidation products will be illustrated...
  12. ncbi request reprint 4-hydroxy-2-nonenal as a COX-2 inducer
    Koji Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Mol Aspects Med 24:213-8. 2003
    ..It appears that the HNE-induced activation of p38 MAPK leads to the stabilization of COX-2 mRNA...
  13. ncbi request reprint 15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses
    Koji Uchida
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Chem Res Toxicol 21:138-44. 2008
    ..In the present perspective, we provide a comprehensive summary of 15d-PGJ (2) as an electrophilic mediator of cellular responses...
  14. doi request reprint Clinical characteristics and outcomes of renal transplantation in elderly recipients
    K Nanmoku
    Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    Transplant Proc 44:281-3. 2012
    ..Since the impacts of advanced recipient age have not yet been fully defined, we evaluated the clinical characteristics and outcomes of elderly renal transplant recipients...
  15. ncbi request reprint Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi
    Y Morimitsu
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, 464 8601, Nagoya, Japan
    Mech Ageing Dev 116:125-34. 2000
    ....
  16. ncbi request reprint Endogenous formation of protein adducts with carcinogenic aldehydes: implications for oxidative stress
    K Ichihashi
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
    J Biol Chem 276:23903-13. 2001
    ..These data suggest that the formation of carcinogenic aldehydes during lipid peroxidation may be causally involved in the pathophysiological effects associated with oxidative stress...
  17. ncbi request reprint Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 273:16058-66. 1998
    ..These results indicate that acrolein is not just a pollutant but also a lipid peroxidation product that could be ubiquitously generated in biological systems...
  18. ncbi request reprint Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University School of Agricultural Sciences, Japan
    Arch Biochem Biophys 346:45-52. 1997
    ..7 and 3.1% of the lysine residues that disappeared during in vitro incubation of LDL with MDA and Cu2+, respectively. These results suggest that N(epsilon)-(2-propenal)lysine represents a major form of MDA covalently attached to proteins...
  19. ncbi request reprint Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress
    Q Feng
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Free Radic Res 35:779-88. 2001
    ..These data suggest that the antioxidants, such as quercetin and tea polyphenols, are inhibitors against mitochondrial ROS production...
  20. ncbi request reprint Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 277:2687-94. 2002
    ..These results strongly suggest that ebselen, a multifunctional antioxidant, is a potential chemopreventive agent in inflammation-associated carcinogenesis...
  21. ncbi request reprint Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress
    M Kondo
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
    J Biol Chem 276:12076-83. 2001
    ....
  22. ncbi request reprint Protein modification by a Maillard reaction intermediate methylglyoxal. Immunochemical detection of fluorescent 5-methylimidazolone derivatives in vivo
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University School of Agricultural Sciences, Japan
    FEBS Lett 410:313-8. 1997
    ....
  23. ncbi request reprint A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages
    Takeshi Kumagai
    Graduate School of Bioagricultural Sciences and Institute for Advanced Research, Nagoya University, Nagoya, Japan
    J Biol Chem 279:48389-96. 2004
    ..These findings suggest that HNE accumulated in macrophages/foam cells may represent an inflammatory mediator that plays a role in stimulation of the inflammatory response and contributes to the progression of atherogenesis...
  24. ncbi request reprint Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice
    K Okada
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464-8601, Japan
    J Nutr 131:2090-5. 2001
    ..These results suggest that U1 is converted to THU1 in vivo and that THU1 is a more promising chemopreventive agent...
  25. ncbi request reprint Thioredoxin as a molecular target of cyclopentenone prostaglandins
    Takahiro Shibata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:26046-54. 2003
    ..These residues may represent the direct sensors of the electrophilic PGs that induce the intracellular redox alteration and neuronal cell death...
  26. ncbi request reprint Role of p38 mitogen-activated protein kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression
    Takeshi Kumagai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Arch Biochem Biophys 397:240-5. 2002
    ..Furthermore, we also found that HNE upregulated the COX-2 expression by the stabilization of COX-2 mRNA via the p38 MAPK pathway...
  27. ncbi request reprint Identification of a lipid peroxidation product as a potential trigger of the p53 pathway
    Takahiro Shibata
    Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    J Biol Chem 281:1196-204. 2006
    ..These data may suggest the potential critical role for ONE in the induction of a neuronal apoptosis program during oxidative processes...
  28. doi request reprint Potent immunosuppression for ABO-incompatible renal transplantation may not be a risk factor for malignancy
    T Yamamoto
    Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    Transplant Proc 44:210-3. 2012
    ..In conclusion, our investigation suggested that potent immunosuppression with splenectomy and cyclophosphamide for ABOi LDRT may not be a risk factor for malignancy...
  29. ncbi request reprint Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells
    Noriyuki Miyoshi
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Cancer Lett 199:113-9. 2003
    ..In conclusion, the results from this study provide biological evidence that ginger-specific constituents other than curcuminoids are potential anticancer agents...
  30. ncbi request reprint Formation of acrolein-derived 2'-deoxyadenosine adduct in an iron-induced carcinogenesis model
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:50346-54. 2003
    ..The data obtained in this study suggest that the formation of a carcinogenic aldehyde through lipid peroxidation may be causally involved in the pathophysiological effects associated with oxidative stress...
  31. ncbi request reprint Endogenous formation of novel halogenated 2'-deoxycytidine. Hypohalous acid-mediated DNA modification at the site of inflammation
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 279:51241-9. 2004
    ..Halogenation (chlorination and/or bromination) of DNA therefore may constitute one mechanism for oxidative DNA damage at the site of inflammation...
  32. ncbi request reprint 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes
    Takahiro Shibata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 277:10459-66. 2002
    ..Moreover, using a chiral high performance liquid chromatography method for separation of PGD(2) metabolites, we established a novel metabolic pathway, in which PGD(2) is converted to 15d-PGJ(2) via an albumin-independent mechanism...
  33. ncbi request reprint Covalent binding of oxidized cholesteryl esters to protein: implications for oxidative modification of low density lipoprotein and atherosclerosis
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:21040-9. 2003
    ..The results of this study suggest that the binding of cholesteryl ester core aldehydes to LDL might represent the process common to the oxidative modification of lipoproteins...
  34. doi request reprint Pupillary autonomic dysfunction in multiple system atrophy and Parkinson's disease: an assessment by eye-drop tests
    Fumitada Yamashita
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Clin Auton Res 20:191-7. 2010
    ..To compare pupillary autonomic dysfunction in multiple system atrophy (MSA) and Parkinson's disease (PD)...
  35. ncbi request reprint Significance of transporter associated with antigen processing gene polymorphism in living related renal transplantation
    T Kobayashi
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Hum Immunol 61:670-4. 2000
    ..It also suggested that donor's antigen presenting cells with the TAP2*0103 allele would have the attenuated efficacy in the presentation of allospecific antigens to recipient's T cells...
  36. ncbi request reprint Comparative study of theefficacy of removal of anti-ABO and anti-gal antibodies by double filtration plasmapheresis
    T Kobayashi
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Xenotransplantation 7:101-8. 2000
    ....
  37. ncbi request reprint Are anemic patients more sensitive to calcineurin inhibitors?
    T Kobayashi
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Transplant Proc 37:1005-6. 2005
    ..A pharmacodynamic study, such as the IL-2 mRNA inhibition test, is preferable for CsA monitoring...
  38. ncbi request reprint Covalent attachment of 4-hydroxy-2-nonenal to erythrocyte proteins
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University School of Agricultural Sciences
    J Biochem 122:1246-51. 1997
    ....
  39. ncbi request reprint An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome
    Takahiro Shibata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochemistry 42:13960-8. 2003
    ..These data suggest that the modulation of proteasome activity may be involved in the mechanism responsible for the accumulation of p53 and subsequent induction of apoptotic cell death induced by 15d-PGJ(2)...
  40. ncbi request reprint Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors
    Hiroko Usami
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 280:25267-76. 2005
    ....
  41. ncbi request reprint Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    FEBS Lett 572:245-50. 2004
    ..The present study also implied the antioxidant role of this detoxification system activation by ZER in the neutralization of lipid peroxidation in hepatocytes, providing a new insight for cancer prevention...
  42. pmc Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein
    Chika Wakita
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 284:28810-22. 2009
    ..The present results not only offer structural insight into sulfhydryl modification by lipid peroxidation products but also provide a platform for the chemical analysis of protein S-associated aldehydes in vitro and in vivo...
  43. ncbi request reprint Formation of Nepsilon-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Lipid Res 47:1386-98. 2006
    ..These data suggest that the formation of DHA-derived adducts such as SUL may be implicated in the oxidative damage observed in DHA-enriched tissues...
  44. ncbi request reprint Protein-bound 4-hydroxy-2-nonenal: an endogenous triggering antigen of antI-DNA response
    Kazuyo Toyoda
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 282:25769-78. 2007
    ..e. the native DNA and protein-bound 4-oxo-2-nonenal). The findings in this study provide evidence to suspect an etiologic role for lipid peroxidation in autoimmune diseases...
  45. ncbi request reprint Immunological detection of 4-hydroxynonenal protein adducts in developing pontine and Purkinje neurons and in karyorrhexis in pontosubicular neuronal necrosis
    Atsuo Itakura
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa, Nagoya 466 8550, Japan
    Early Hum Dev 67:19-28. 2002
    ..Our results identified the presence of oxidative stress in the perinatal neuron, and this oxidative stress may contribute to some forms of karyorrhectic death...
  46. ncbi request reprint Pivotal role of electrophilicity in glutathione S-transferase induction by tert-butylhydroquinone
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Biochemistry 42:4300-9. 2003
    ..Thus, we conclude that an electrophilic quinone oxidation product that reacts with intracellular nucleophiles including protein thiol or GSH plays a major role in the GSTP1 gene expression...
  47. ncbi request reprint Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 277:8492-9. 2002
    ..These results suggest that BITC induces apoptosis through a mitochondrial redox-sensitive mechanism...
  48. ncbi request reprint A phase II detoxification enzyme inducer from lemongrass: identification of citral and involvement of electrophilic reaction in the enzyme induction
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 302:593-600. 2003
    ..The present study also implied the antioxidant role of GST induction by citral in mouse skin, providing a new insight into skin cancer prevention...
  49. ncbi request reprint Electron microscopic peritubular capillary lesions: a new criterion for chronic rejection
    T Oikawa
    Third Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
    Clin Transplant 13:24-32. 1999
    ..We concluded that MLPTC is useful as a specific criterion for chronic rejection...
  50. ncbi request reprint Usefulness of monitoring of AUC(0-4h) during the induction period of immunosuppressive therapy with tacrolimus after renal transplantation
    K Uchida
    Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan
    Transplant Proc 34:1736-7. 2002
  51. ncbi request reprint Beneficial effect of antibody removal and enhanced immuno suppression in flow cytometry cross match-positive and ABO-incompatible renal transplantation
    A Katayama
    Kidney Center, Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    Transplant Proc 34:2771-2. 2002
  52. ncbi request reprint A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation
    Noriyuki Miyoshi
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Cancer Res 64:2134-42. 2004
    ..Thus, we identified the phosphorylated Bcl-2 as a key molecule linking the p38 MAPK-dependent cell cycle arrest with the JNK activation by BITC...
  53. ncbi request reprint [Current opinions on prostaglandin J2]
    Takahiro Shibata
    Graduate School of Bioagricultural Sciences, Nagoya University, Furocho, Chikusa ku, Nagoya, Aichi, 464 8601, Japan
    Seikagaku 77:1189-92. 2005
  54. ncbi request reprint Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2
    Takeshi Ishii
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Chem Res Toxicol 17:1313-22. 2004
    ..These results suggest that cysteine-targeted oxidation/thiolation plays a critical role in the regulation of protein function under conditions of electrophile-induced oxidative stress...
  55. doi request reprint Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells
    Yuri Kusano
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochemistry 47:6169-77. 2008
    ..The results of this study suggest the involvement of a novel Keap1-dependent signaling pathway for the induction of the constitutive GST A1 expression during epithelial cell differentiation...
  56. ncbi request reprint A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway
    Yasujiro Morimitsu
    Laboratory of Food and Biodynamics and the Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 277:3456-63. 2002
    ....
  57. pmc Bispecific abs against modified protein and DNA with oxidized lipids
    Mitsugu Akagawa
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 103:6160-5. 2006
    ..Molecular mimicry between the R-HNE-histidine configurational isomers and the ONE-DNA base adducts is proposed for the dual crossreactivity...
  58. pmc Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies
    Natsuki Otaki
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 285:33834-42. 2010
    ..These findings raised the possibility that the enhanced lipid peroxidation followed by the generation of ONE may be involved in the pathogenesis of autoimmune disorders...
  59. ncbi request reprint Granulatoside A, a starfish steroid glycoside, enhances PC12 cell neuritogenesis induced by nerve growth factor through an activation of MAP kinase
    Jianhua Qi
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    ChemMedChem 1:1351-4. 2006
  60. ncbi request reprint Osteoprotegerin levels before and after renal transplantation
    T Sato
    Department of Transplant Surgery, Nagoya 2nd Red Cross Hospital, Nagoya, Japan
    Am J Kidney Dis 38:S175-7. 2001
    ..Serum OPG declines for the first 2 weeks after RTX owing to functioning allograft and decreases again for the next 2 weeks because of steroids and possible immunosuppressive agents...
  61. ncbi request reprint Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, wasabi
    Y Morimitsu
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Japan
    Biofactors 13:271-6. 2000
    ....
  62. ncbi request reprint Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells
    Q Feng
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Xenobiotica 32:1033-43. 2002
    ..The autoclaved tryptophan contained in an autoclavable medium was a more potent inducer of CYP1A1 than photo-oxidized tryptophan. 3. The results provide some practical suggestions with experiments related to CYP1A1...
  63. ncbi request reprint Cyclosporine nephrotoxicity: how does it affect renal allograft function and transplant morphology?
    K Morozumi
    Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    Transplant Proc 36:251S-256S. 2004
    ..The FGS lesion accompanying CAA is considered to be CSA-associated glomerulopathy. These data contribute to therapeutic plans for renal transplant patients during long-term CSA treatment...
  64. ncbi request reprint Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal
    Masaya Kanayama
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 282:24166-74. 2007
    ..These findings represent a demonstration of a link between lipoprotein modification and activation of the inflammatory potential of macrophages...
  65. ncbi request reprint Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures
    Qing Feng
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Agric Food Chem 50:213-20. 2002
    ..However, theaflavins could inhibit this DNA damage. These results indicated that theaflavins could prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures...
  66. ncbi request reprint Oxidative modification of proteasome: identification of an oxidation-sensitive subunit in 26 S proteasome
    Takeshi Ishii
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochemistry 44:13893-901. 2005
    ....
  67. ncbi request reprint Ebselen, a seleno-organic antioxidant, as an electrophile
    Toyo Sakurai
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Chem Res Toxicol 19:1196-204. 2006
    ..Thus, this unique antioxidant and electrophilic property of ebselen giving rise to the cysteine-targeted oxidation enabled us to evaluate the role of sensor cysteines in redox regulation of protein function under electrophile stress...
  68. ncbi request reprint Immunohistochemical detection of a substituted 1,N(2)-ethenodeoxyguanosine adduct by omega-6 polyunsaturated fatty acid hydroperoxides in the liver of rats fed a choline-deficient, L-amino acid-defined diet
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Carcinogenesis 23:485-9. 2002
    ..Collectively, the results in this study suggest the first evidence that the formation of Oxo-heptyl-varepsilondG, the omega-6 lipid hydroperoxide-mediated DNA adduct, may be a potential biomarker for the early phase of carcinogenesis...
  69. pmc Lipid peroxidation generates body odor component trans-2-nonenal covalently bound to protein in vivo
    Kousuke Ishino
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 285:15302-13. 2010
    ....
  70. doi request reprint Identification of advanced reaction products originating from the initial 4-oxo-2-nonenal-cysteine Michael adducts
    Yuuki Shimozu
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Chem Res Toxicol 22:957-64. 2009
    ..Thus, this study identified the novel ONE-cysteine adducts, including the most prominent 2-cyclopentenone derivatives, that originated from the initial Michael adducts...
  71. ncbi request reprint Increase in oxidative stress in kidneys of diabetic Akita mice
    Yuki Ueno
    Nagoya University Graduate School of Bioagricultural Sciences, Japan
    Biosci Biotechnol Biochem 66:869-72. 2002
    ..These results suggest that hyperglycemia in Akita mice induced oxidative stress and increased these markers in the kidneys...
  72. doi request reprint A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction
    Takahiro Shibata
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    J Neurochem 107:1248-60. 2008
    ..The identification of PTP1B as a regulator of NGF signaling may provide new clues about the chemoprotective potential of food components, such as isothiocyanates...
  73. doi request reprint Protein N-acylation: H2O2-mediated covalent modification of protein by lipid peroxidation-derived saturated aldehydes
    Kousuke Ishino
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Chem Res Toxicol 21:1261-70. 2008
    ..These data suggest that the hydroperoxides, including H2O2, might be involved not only in the oxidative modification of protein but also in the covalent binding of the saturated aldehydes to proteins under oxidative stress...
  74. ncbi request reprint Esterified lipid hydroperoxide-derived modification of protein: formation of a carboxyalkylamide-type lysine adduct in human atherosclerotic lesions
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 313:271-6. 2004
    ..These results suggest that esterified lipid hydroperoxide-derived modification of protein may serve as one mechanism for the oxidative modification of LDL and subsequent formation of atherosclerotic lesions in vivo...
  75. ncbi request reprint 2'-deoxycytidine in free nucleosides and double-stranded DNA as the major target of lipid peroxidation products
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Free Radic Biol Med 36:529-41. 2004
    ..dC and that the formation of 4-oxo-2-alkenal-adducted dC may thus serve as one mechanism for oxidative damage to DNA in vivo...
  76. pmc 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis
    Mitsuhiro Kondo
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 99:7367-72. 2002
    ..The 15d-PGJ(2)-induced accumulation of p53 resulted in the activation of a death-inducing caspase cascade mediated by Fas and the Fas ligand...
  77. doi request reprint Pretransplant pharmacodynamic analysis of immunosuppressive agents using CFSE-based T-cell proliferation assay
    Y Kurata
    Department of Clinical Pharmacy, College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan
    Clin Pharmacol Ther 86:285-9. 2009
    ..In addition to post-transplant blood-level monitoring, pretransplant pharmacodynamics could provide useful information on optimal and safe immunosuppressive therapy...
  78. ncbi request reprint Removal of alpha-galactosyl antigens from vascular endothelial cells in pig organs by intravenous infusion of endo-beta-galactosidase
    D Liu
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Transplant Proc 34:2755. 2002
  79. ncbi request reprint Metal-catalyzed oxidation of protein-bound dopamine
    Mitsugu Akagawa
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochemistry 45:15120-8. 2006
    ....
  80. doi request reprint Catechol type polyphenol is a potential modifier of protein sulfhydryls: development and application of a new probe for understanding the dietary polyphenol actions
    Takeshi Ishii
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Chem Res Toxicol 22:1689-98. 2009
    ..These results provide an alternative approach to understand that catechol type polyphenol is a potential modifier of redox-dependent cellular events through sulfhydryl modification...
  81. ncbi request reprint Mass spectroscopic characterization of protein modification by malondialdehyde
    Takeshi Ishii
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusaku, Nagoya 464 8601, Japan
    Chem Res Toxicol 19:122-9. 2006
    ....
  82. ncbi request reprint Thiolation of protein-bound carcinogenic aldehyde. An electrophilic acrolein-lysine adduct that covalently binds to thiols
    Atsunori Furuhata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 277:27919-26. 2002
    ....
  83. ncbi request reprint N(epsilon)-(3-methylpyridinium)lysine, a major antigenic adduct generated in acrolein-modified protein
    Atsunori Furuhata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:48658-65. 2003
    ..More notably, this condensation adduct appeared to be an intrinsic epitope of a monoclonal antibody 5F6 that had been raised against acrolein-modified protein...
  84. ncbi request reprint Benzyl isothiocyanate modifies expression of the G2/M arrest-related genes
    Noriyuki Miyoshi
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya, Japan
    Biofactors 21:23-6. 2004
    ..Thus, these gathered data further supported that BITC has a potential to induce apoptosis selectively in the proliferating pre-cancerous cells through a cell cycle arrest-dependent mechanism...
  85. ncbi request reprint Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds
    Qing Feng
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, 464 8601, Nagoya, Japan
    Mutat Res 537:101-8. 2003
    ..71). The results suggest that the lipophilicity of the phenolic compounds may be an important factor in their ability to inhibit EROD activity...
  86. ncbi request reprint Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation
    H Osada
    Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, Nagoya, Japan
    Biochem Biophys Res Commun 229:582-9. 1996
    ..In contrast, a truncated LIMK2-Kinase has a nuclear location, not showing the protein association...
  87. ncbi request reprint Alpha-tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli
    Noriyuki Miyoshi
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 334:466-73. 2005
    ..These findings provide biological evidence showing that (+)-alpha-tocopherol can amplify the apoptotic response by up-regulating the expression of pro-caspase-3...
  88. ncbi request reprint Molecular basis of enzyme inactivation by an endogenous electrophile 4-hydroxy-2-nonenal: identification of modification sites in glyceraldehyde-3-phosphate dehydrogenase
    Takeshi Ishii
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochemistry 42:3474-80. 2003
    ....
  89. ncbi request reprint Structural basis of protein-bound endogenous aldehydes. Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct
    Mika Hashimoto
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:5044-51. 2003
    ....
  90. doi request reprint Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage
    Yoshichika Kawai
    Laboratory of Food Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Chem Res Toxicol 21:1407-14. 2008
    ..These results showed that green tea catechins, especially 3-galloylated catechins, may be the plausible candidate for the prevention of inflammation-derived DNA damage and perhaps carcinogenesis...
  91. ncbi request reprint Carbonyl stress and detoxification ability in the male genital tract and testis of rats
    Yoshihito Iuchi
    Department of Biochemistry, Yamagata University School of Medicine, 2 2 2 Iidanishi, 990 9585 Yamagata, Japan
    Histochem Cell Biol 121:123-30. 2004
    ..The colocalization of lipid peroxidation products and AKR in the epithelia of the male genital tract indicates that these tissues are exposed to oxidative stress and possess a protective system coordinately...
  92. pmc Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)
    Ken Itoh
    ERATO Environmental Response Project, University of Tsukuba, Tsukuba 305 8577, Japan
    Mol Cell Biol 24:36-45. 2004
    ..These results demonstrate that Nrf2 regulates the inflammation process downstream of 15d-PGJ(2) by orchestrating the recruitment of inflammatory cells and regulating the gene expression within those cells...
  93. ncbi request reprint Hypothermia attenuates delayed cortical cell death and ROS generation following CO inhalation
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Toxicol Lett 145:101-6. 2003
    ..CO inhalation injures neuron by reactive oxygen species (ROS), independent of hypoxia, as can be concluded from the histological comparison of DCD with HNE immunoreactivity...
  94. ncbi request reprint Maillard reaction-like lysine modification by a lipid peroxidation product: immunochemical detection of protein-bound 2-hydroxyheptanal in vivo
    Koichi Itakura
    Faculty of Education, Aichi University of Education, Kariya, Japan
    Biochem Biophys Res Commun 308:452-7. 2003
    ..By using this antibody, it was revealed that the antigenic structure was indeed present in atherosclerotic lesions of the human aorta...
  95. ncbi request reprint Reaction of N(alpha)-hippuryllysine with 2-hydroxyheptanal: a model for lysine-directed protein modifications by lipid peroxidation
    Koichi Itakura
    Faculty of Education, Aichi University of Education, 448 8542 Kariya, Japan
    Chem Phys Lipids 124:81-8. 2003
    ..This conversion was strongly accelerated by the addition of copper(II) ion and 2,2'-bipyridyl. We propose here that the above series of conversions is the main pathway for the modification of lysine residues of proteins by 2-HH...
  96. ncbi request reprint Lysine-derived fluorophores formed by autoxidation of linoleic acid
    Koichi Itakura
    Faculty of Education, Aichi University of Education, 448 8542, Kariya, Japan
    Chem Phys Lipids 123:187-91. 2003
    ....
  97. ncbi request reprint Protective effect of colored rice over white rice on Fenton reaction-based renal lipid peroxidation in rats
    Shinya Toyokuni
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan
    Free Radic Res 36:583-92. 2002
    ..These may partly explain the antioxidative effect. Furthermore, colored strains of rice are rich in proteins. Thus, our data warrants further investigation of the antioxidative effect of colored rice...
  98. ncbi request reprint Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids
    Satoshi Yamada
    Tsukuba Research Laboratory, NOF Corporation, Tsukuba 300 2635, Japan
    J Lipid Res 45:626-34. 2004
    ..The results of this study suggest that the reaction between oxidized n-3 PUFAs and protein might represent a process common to the formation of degenerative proteins during aging and its related diseases...
  99. ncbi request reprint Rapid formation of 4-hydroxy-2-nonenal, malondialdehyde, and phosphatidylcholine aldehyde from phospholipid hydroperoxide by hemoproteins
    Takaaki Hayashi
    Hokkaido Institute of Public Health, Kita 12, Nishi 6, Kita ku, Sapporo 060 0819, Japan
    Free Radic Biol Med 36:1025-33. 2004
    ..These results suggest that hemoproteins are related to both the formation and the decomposition of HNE...
  100. ncbi request reprint Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine
    Noriko Mizutani
    Department of Gastroenterology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Immunol 179:7478-87. 2007
    ..03 nM FKN and produced TNF-alpha in a CX3CR1-dependent manner. These dose-dependent differential effects of FKN establish its novel role in immune homeostasis and inflammation...
  101. ncbi request reprint Effects of N-acetylcysteine, quercetin, and phytic acid on spontaneous hepatic and renal lesions in LEC rats
    Yasuki Kitamura
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8501, Japan
    Toxicol Pathol 33:584-92. 2005
    ..In addition, it was suggested that the different effects of the anti-oxidants on lesion development in LEC rats might be related to different mechanisms of action with regard to oxidative stress...