Hiroyuki Tsuda

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats
    Naomi Hokaiwado
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601
    Cancer Sci 94:1042-5. 2003
  2. ncbi request reprint High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 96:309-16. 2005
  3. ncbi request reprint Cancer prevention by natural compounds
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Japan
    Drug Metab Pharmacokinet 19:245-63. 2004
  4. ncbi request reprint Toxicology of engineered nanomaterials - a review of carcinogenic potential
    Hiroyuki Tsuda
    Nanotoxicology Project, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Asian Pac J Cancer Prev 10:975-80. 2009
  5. ncbi request reprint Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Food Chem Toxicol 45:1013-9. 2007
  6. ncbi request reprint Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice
    Yoko Sagawa
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Toxicol Sci 37:317-27. 2012
  7. doi request reprint An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas
    Katsumi Fukamachi
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Biochem Biophys Res Commun 390:636-41. 2009
  8. ncbi request reprint Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas
    Shinobu Ueda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 27:2497-510. 2006
  9. doi request reprint Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats
    Jiegou Xu
    Laboratory of Nanotoxicology Project, Nagoya City University, Nagoya, Japan
    Cancer Sci 103:2045-50. 2012
  10. ncbi request reprint Comparative study of toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro
    Takamasa Numano
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan E mail
    Asian Pac J Cancer Prev 15:929-35. 2014

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats
    Naomi Hokaiwado
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601
    Cancer Sci 94:1042-5. 2003
    ....
  2. ncbi request reprint High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 96:309-16. 2005
    ....
  3. ncbi request reprint Cancer prevention by natural compounds
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Japan
    Drug Metab Pharmacokinet 19:245-63. 2004
    ..Here we review naturally occurring compounds useful for cancer chemprevention based on in vivo studies with reference to their structures, sources and mechanisms of action...
  4. ncbi request reprint Toxicology of engineered nanomaterials - a review of carcinogenic potential
    Hiroyuki Tsuda
    Nanotoxicology Project, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Asian Pac J Cancer Prev 10:975-80. 2009
    ..These findings are similar to the biological effects of asbestos, a potent carcinogen, and indicate that careful assessment of NPs is indispensable...
  5. ncbi request reprint Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Food Chem Toxicol 45:1013-9. 2007
    ..Tongue SCC induction of wild males and all females was not significant. The present results suggest that DAG oil may have enhancing and/or promotion potential for tongue carcinogenesis in male Tg featuring elevated ras expression...
  6. ncbi request reprint Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice
    Yoko Sagawa
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Toxicol Sci 37:317-27. 2012
    ..Our results indicate that treatment with sTiO(2) or ncTiO(2) did not promote skin carcinogenesis in mice or rats, probably due to lack of penetration through the epidermis...
  7. doi request reprint An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas
    Katsumi Fukamachi
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Biochem Biophys Res Commun 390:636-41. 2009
    ..Even in rats with very small microscopic ductal carcinoma lesions, elevated serum Erc/Mesothelin can be detected. We believe this is the first report of a pancreas tumor animal model in which pre-symptomatic lesions can be diagnosed...
  8. ncbi request reprint Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas
    Shinobu Ueda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 27:2497-510. 2006
    ..This model exhibits important similarities to the human disease and promises to advance our understanding of the behavior of pancreas adenocarcinomas and expedite screening and therapy...
  9. doi request reprint Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats
    Jiegou Xu
    Laboratory of Nanotoxicology Project, Nagoya City University, Nagoya, Japan
    Cancer Sci 103:2045-50. 2012
    ..In conclusion, intrapulmonary administration of multi-walled carbon nanotubes, like asbestos, induced mesothelial proliferation potentially associated with mesothelioma development...
  10. ncbi request reprint Comparative study of toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro
    Takamasa Numano
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan E mail
    Asian Pac J Cancer Prev 15:929-35. 2014
    ..In conclusion, our results indicate that anTiO2 is less potent in induction of alveolar macrophage infiltration, 8-OHdG and MIP1??expression in the lung, and growth stimulation of A549 cells in vitro than rnTiO2. ..
  11. doi request reprint Involvement of macrophage inflammatory protein 1alpha (MIP1alpha) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying
    Jiegou Xu
    Department of Molecular Toxicology, University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 31:927-35. 2010
    ....
  12. doi request reprint Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats
    Jiegou Xu
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Food Chem Toxicol 49:1298-302. 2011
    ..Our data suggest that TiO(2) does not cause skin carcinogenesis, probably due to its inability to penetrate through the epidermis and reach underlying skin structures...
  13. doi request reprint A novel reporter rat strain that expresses LacZ upon Cre-mediated recombination
    Katsumi Fukamachi
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Genesis 51:268-74. 2013
    ..The LacZ541 rat enables evaluation of the performance of Cre-expressing systems which are based upon transgenic rats or somatic gene transfer vectors and provides efficient and simple lineage marking...
  14. pmc Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles
    Jiegou Xu
    Laboratory of Nanotoxicology Project, Nagoya City University, 3 1 Tanabedohri Mizuho ku, Nagoya, 467 8603, Japan
    Arch Toxicol 88:65-75. 2014
    ..In summary, nZnO did not promote carcinogenesis in the lung and induced EHTB and FAIP lesions that regressed rapidly, probably due to clearance of surplus Zn(2+) from the lung. ..
  15. ncbi request reprint Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    Cancer Res 67:11353-8. 2007
    ..Thus, these data suggested that GPX2 may be involved in mammary carcinogenesis and cell proliferation in both rats and humans, indicating that GPX2 may be a novel target for the prevention and therapy of breast cancer...
  16. ncbi request reprint Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model
    Yuriko Watanabe
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Res 73:344-8. 2013
    ..We examined the extent of fetal lung hypoplasia and lung maturation using the amniotic lamellar body count (LBC) in congenital diaphragmatic hernia (CDH)...
  17. doi request reprint Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats
    Hajime Tanaka
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Sci 101:341-6. 2010
    ..In marked contrast, injection of Ad-CAG-Cre resulted in pancreatic cancer development within 4 weeks. These results indicate that adult acinar cells are refractory to Ras oncogene activation and do not develop neoplasia in this model...
  18. ncbi request reprint Construction of a multi-functional helper-dependent adenovirus based system for cancer gene therapy
    Ne Long
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Japan
    Asian Pac J Cancer Prev 10:939-60. 2009
    ..This type of system could be very useful in cancer therapy: For example, libraries of different cassettes could be maintained, allowing rapid assembly of constructs able to provide therapy for individual tumor types...
  19. doi request reprint A medium-term, rapid rat bioassay model for the detection of carcinogenic potential of chemicals
    Hiroyuki Tsuda
    Nanotoxicology Project, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho ku, Mizuho cho, Nagoya 467 8601, Japan ac jp
    Toxicol Pathol 38:182-7. 2010
    ..Forty-four compounds were tested using the Ito Multi-organ Model: 17 out of 17 liver carcinogens were positive, and 19 out of 22 (86%) nonliver carcinogens were positive. None of the five noncarcinogens tested positive...
  20. doi request reprint Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat
    Katsumi Fukamachi
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 99:1841-6. 2008
    ..Secondly, the in vitro-in vivo system used in this study can be utilized for screening for cancer preventive compounds that act via Ras down-regulation...
  21. doi request reprint Mucinous cystic neoplasm of the pancreas with severe dysplasia during pregnancy: case report and review of the literature
    Hiroyuki Tsuda
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
    Taiwan J Obstet Gynecol 51:635-8. 2012
    ..Mucinous cystic neoplasm (MCN) of the pancreas occurs mainly in women aged 40-60 years, so it is extremely rare in pregnant woman...
  22. doi request reprint Lactoferrin: an alternative view of its role in human biological fluids
    David B Alexander
    Laboratory of Nanotoxicology Project, Nagoya City University, 3 1 Tanabedohri, Mizuho ku, Nagoya 467 8603, Japan
    Biochem Cell Biol 90:279-306. 2012
    ..Using this information, we briefly discuss hLF in the context of the complex biological fluids in which it is found...
  23. doi request reprint Cancer prevention by bovine lactoferrin: from animal studies to human trial
    Hiroyuki Tsuda
    Nanotoxicology Project, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Biometals 23:399-409. 2010
    ..Here we review work which established bLF as an anti-carcinogenic agent in laboratory animals and the results of a clinical trial which demonstrated that bLF can reduce the risk of colon carcinogenesis in humans...
  24. ncbi request reprint Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor
    Tomomi Kotani
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Nagoya, Japan
    Biol Reprod 89:52. 2013
    ..01), respectively, in the HAECs. ET-1 was increased 2-fold by S1P (P < 0.01). These results suggest that the altered expression of enzymes regulating the activity of ET-1 during parturition is controlled by inflammatory cytokines. ..
  25. ncbi request reprint Diethylnitrosamine-induced hepatic lesions are greater in rats maintained under a light-dark cycle than under constant light, related to the locomotor activity rhythm
    Yoshiaki Isobe
    Department of Neuro physiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Asian Pac J Cancer Prev 9:619-24. 2008
    ..Two weeks after DEN injection, locomotor activity in 24 hr had increased under the LD. Circadian rhythmicity might be coupled with the carcinogenicity of DEN...
  26. ncbi request reprint [Hazard identification of nanomaterials]
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Yakugaku Zasshi 128:1727-32. 2008
    ..Manufacturers can produce safer products without risking themselves waiting for the toxicology studies to be finished after their products are widely marketed...
  27. ncbi request reprint Risk assessment studies of nanomaterials in Japan and other countries
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Science, Mizuho ku, Nagoya, Japan
    Asian Pac J Cancer Prev 11:13-4. 2010
    ..The summary of nanotoxicology studies shown below clearly indicates that compared with the UK, EU, USA, and other countries, Japanese studies regarding metals and SWCNT are far from sufficient to evaluate risk...
  28. doi request reprint Validity of lamellar body count as a fetal lung maturity assessment in twin pregnancy
    Hiroyuki Tsuda
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
    Twin Res Hum Genet 15:547-9. 2012
    ..An LBC value of >2.95×10⁴/μL means reassuring findings for RDS even in twin pregnancy. We believe the data in this study provide valuable, new information for the management of twin pregnancies...
  29. ncbi request reprint Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens
    Takamasa Ohnishi
    Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Toxicol Pathol 35:436-43. 2007
    ..Thus various carcinogens, not necessarily limited to those normally targeting the breast, were found to induce mammary carcinomas in Hras128 rats, especially in females, pointing to potential use for medium-term screening...
  30. ncbi request reprint An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 27:619-30. 2006
    ....
  31. ncbi request reprint Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment
    Makoto Asamoto
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:32-5. 2002
    ..These results indicate that aberrant c-Ha-ras gene expression is involved in ovarian hormone-independent growth and c-Ha-ras protein isoprenylation plays an important role in mammary carcinogenesis...
  32. ncbi request reprint Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: possible application for screening of chemopreventive agents
    Yoichiro Matsuoka
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Toxicol Pathol 31:632-7. 2003
    ..These results suggest that this model has practical utility for short-term screening of chemopreventive agents for mammary carcinogenesis...
  33. ncbi request reprint Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:300-5. 2004
    ..These results might suggest that dietary feeding of the estrogenic compounds tOP and BBP did not modulate DMAB-induced prostatic carcinogenesis in rats...
  34. ncbi request reprint Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate
    Cheol Beom Park
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:205-10. 2004
    ....
  35. ncbi request reprint Terminal endbuds and acini as the respective major targets for chemical and sporadic carcinogenesis in the mammary glands of human c-Ha-ras protooncogene transgenic rats
    Tetsuya Hamaguchi
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tsukiji, Chuo Ku, Tokyo, Japan
    Breast Cancer Res Treat 83:43-56. 2004
    ..Our data suggest that TEBs and acini are the major targets for chemical and sporadic carcinogenesis, respectively, in the mammary glands of human c-Ha-ras protooncogene transgenic rats...
  36. ncbi request reprint Possible enhancing effects of atrazine and nonylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats
    Katsumi Fukamachi
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:404-10. 2004
    ..The doses applied, moreover, were all extremely high compared to the possible environmental human exposure levels...
  37. ncbi request reprint Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention
    Yoichiro Matsuoka
    Second Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka, Japan
    Med Mol Morphol 40:185-90. 2007
    ..In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention...
  38. ncbi request reprint A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue
    Takuji Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Oncology 64:166-75. 2003
    ....
  39. ncbi request reprint Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis
    Makoto Asamoto
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:744-51. 2002
    ....
  40. ncbi request reprint Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat
    Ken ichi Fujita
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 213:21-9. 2004
    ..These results indicate that Fas and pro-apoptotic Bcl-2 members participate in the lactoferrin action and may contribute to suppressive effects on tumor development in the rat colon...
  41. ncbi request reprint Inhibitory effects of 17beta-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats
    Beom Seok Han
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 23:1209-15. 2002
    ..In addition, the results suggest that Tg rats can be used in medium-term bioassay models to test for the modifying effects of estrogenic environmental compounds on mammary tumor development...
  42. ncbi request reprint Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats
    Akihiro Naito
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:399-403. 2004
    ....
  43. pmc Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells
    Gary S Goldberg
    Department of Physiology and Biophysics, School of Medicine, Basic Science Tower T6, Health Science Complex, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    J Biol Chem 278:46533-40. 2003
    ..Thus, a single phosphorylation site on this focal adhesion adaptor protein can effectively separate cell migration from other transformed growth characteristics...
  44. ncbi request reprint Carcinogenesis and its modification by environmental endocrine disruptors: in vivo experimental and epidemiological findings
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Jpn J Clin Oncol 33:259-70. 2003
    ..Thus, careful in vivo assessment is required before drawing any conclusions regarding agents capable of affecting the mammalian endocrine system...
  45. ncbi request reprint Can risk assessment and chemoprevention research rely on surrogates for tumour yield?
    Malcolm A Moore
    Asian Pac J Cancer Prev 4:167-8. 2003
  46. ncbi request reprint Experimental investigation of opisthorchiasis-associated cholangiocarcinoma induction in the Syrian hamster - pointers for control of the human disease
    Suchart Chaimuangraj
    Urology Department of Surgery, Ramathibodi Hospital, Rama VI, Bangkok 10400, Thailand
    Asian Pac J Cancer Prev 4:87-93. 2003
    ....
  47. ncbi request reprint Appropriate models and an understanding of carcinogenic mechanisms--requirements for hazard risk assessment
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, Asahi machi, Osaka 545 8585, Japan
    Asian Pac J Cancer Prev 4:75-8. 2003
    ..The onus is on all members of the scientific community to impartially view all the epidemiological and experimental data which are available in decision-making...
  48. ncbi request reprint Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 11:4962-7. 2005
    ..Here, we investigated the modifying effects of dietary feeding with a naturally occurring polyphenolic antioxidant flavonoid silymarin on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced prostatic carcinogenesis in male F344 rats...
  49. ncbi request reprint Cancer screening literature in the period 2000-2002: pointers to future research avenues
    Malcolm A Moore
    Division of Chemotherapy and Experimental Pathology, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Asian Pac J Cancer Prev 4:57-60. 2003
    ....
  50. ncbi request reprint Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Toxicol Pathol 31:80-6. 2003
    ....
  51. ncbi request reprint Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Jpn J Cancer Res 93:1076-82. 2002
    ..These results imply that there is a no-observed effect level for hepatocarcinogenesis by these genotoxic carcinogens...
  52. ncbi request reprint Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats
    Ken ichi Fujita
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045
    Jpn J Cancer Res 93:616-25. 2002
    ..One possible mechanism is a normalizing down-regulation of CYP1A2 expression by bLF, with consequent reduction of carcinogen activation and adduct formation...
  53. ncbi request reprint Establishment of an apoptosis-sensitive rat mammary carcinoma cell line with a mutation in the DNA-binding region of p53
    Tetsuya Hamaguchi
    Second Department of Surgery, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 0001, Japan
    Cancer Lett 232:279-88. 2006
    ..These data suggest that the apoptosis induced by intracellular injury occurs via the transcriptionally impaired mutant p53 in C11...
  54. ncbi request reprint Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 191:35-40. 2003
    ..001-1 ppm. The results imply a no-observed effect level for hepatocarcinogenicity with this genotoxic agent...
  55. ncbi request reprint Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 222:11-5. 2005
    ....
  56. ncbi request reprint Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis
    Hiroshi Nomoto
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Nutr Cancer 49:81-8. 2004
    ..PA at fairly low doses in the long term might serve as an effective means for preventing colon carcinogenesis...
  57. ncbi request reprint Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats
    Keiichirou Morimura
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Toxicol Pathol 33:764-7. 2005
    ..In conclusion, Na-AsA did not show tumorigenicity in highly bladder-cancer-susceptible transgenic Hras128 rats. These results suggest that Na-AsA is a pure promoter but not a complete carcinogen in rats...
  58. ncbi request reprint Awareness and high relative mortality rates in the asian pacific
    Malcolm A Moore
    Asian Pac J Cancer Prev 5:91-3. 2004
  59. ncbi request reprint Cancer chemoprevention--how feasible?
    Malcolm A Moore
    Asian Pac J Cancer Prev 7:165-6. 2006
  60. ncbi request reprint Bovine lactoferrin inhibits tumor-induced angiogenesis
    Mariko Shimamura
    Medical R and D Center, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Int J Cancer 111:111-6. 2004
    ..Antitumor activity of bLF may thus be partly mediated by angiogenesis inhibition...
  61. ncbi request reprint Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats
    Ken ichi Fujita
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 25:1961-6. 2004
    ..These results suggest that apoptosis caused by elevated expression of Fas is involved in chemoprevention by lactoferrin of colon carcinogenesis...
  62. doi request reprint Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis
    Yoichiro Matsuoka
    Second Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    Cancer Sci 99:309-15. 2008
    ....
  63. pmc Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic
    Gene Kurosawa
    Division of Antibody Project, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Proc Natl Acad Sci U S A 105:7287-92. 2008
    ....
  64. pmc Establishment of rat embryonic stem cells and making of chimera rats
    Shinobu Ueda
    Section for Studies on Metastasis, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 3:e2800. 2008
    ..Most importantly, the rES cells are capable of producing chimera rats. Therefore, we established pluripotent rES cell lines that are widely used to produce genetically modified experimental rats for study of human diseases...
  65. ncbi request reprint Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity
    David B Alexander
    Department of Physiology and Biophysics, School of Medicine, Health Sciences Complex, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    Cancer Res 64:1347-58. 2004
    ..In addition, these results suggest mechanisms by which normal cells may block Wnt signaling, inhibit insulin-like growth factor activity, and promote host recognition of neighboring tumor cells...
  66. ncbi request reprint Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis
    Masaaki Iigo
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cytokine 25:36-44. 2004
    ....
  67. ncbi request reprint Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Cell Biol 80:131-6. 2002
    ..More extensive clinical trials are now underway in the National Cancer Center Hospital and other institutes to further explore the preventive potential against colon carcinogenesis...