Genomes and Genes
Affiliation: Nagoya University
- The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gutShigeko Torihashi
Department of Health Science, Nagoya University Graduate School of Medicine, 1 1 20 Daikouminami, Higashi ku, Nagoya 461 8673, Japan
Differentiation 77:277-89. 2009..Taken together, BMP signaling was expressed for a short window in the smooth muscle progenitors and the signal, especially BMP2, plays an essential role in smooth muscle differentiation in cooperation with PDGF signaling...
- In vitro developmental model of the gastrointestinal tract from mouse embryonic stem cellsShigeko Torihashi
Programs in Physical and Occupational Therapy, Nagoya University Graduate School of Medicine, 1 1 20 Daiko Minami, Higashi ku, Nagoya 461 8673, Japan
Nagoya J Med Sci 69:133-7. 2007..In addition, we pointed out several unique features different from gut in vivo that provide useful and advantageous tools to investigate the developmental mechanism of the gastrointestinal tract...
- Gut-like structures from mouse embryonic stem cells as an in vitro model for gut organogenesis preserving developmental potential after transplantationShigeko Torihashi
Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Stem Cells 24:2618-26. 2006..They maintain their developmental potential after transplantation. Therefore, gut-like structures provide a unique and useful in vitro system for development and stem cell studies of the GI tract, including transplantation experiments...
- Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cellsRie Matsuura
Department of Anatomy and Molecular Cell Biology, Graduate School of Medicine, Nagoya University, Japan
Stem Cells 24:624-30. 2006..They also indicate that the in vitro system using mouse ES cells mimics in vivo development and should prove useful in the study of molecular mechanisms for endoderm and gut development...
- Formation of gut-like structures in vitro from mouse embryonic stem cellsShigeko Torihashi
Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Japan
Methods Mol Biol 330:279-85. 2006..EBs develop to form gut-like structures when induced to spontaneously enter a program of differentiation in vitro without addition of any extrinsic factors...
- Attenuated nitrergic inhibitory neurotransmission to interstitial cells of Cajal in the lower esophageal sphincter with esophageal achalasia in childrenYoshio Watanabe
Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
Pediatr Int 44:145-8. 2002..The aim of this investigation is to clarify the status of ICC and nitrergic inhibitory neurons in the LES of EA using immunohistochemistry...
- Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolaeShigeko Torihashi
Department of Anatomy, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
J Biol Chem 277:19191-7. 2002..Taken together, the results infer that the Ca(2+) oscillation in ICC is intimately linked to the pacemaker function and depends on Ca(2+) influx mediated by TRP4...
- Spontaneous rhythmicity in cultured cell clusters isolated from mouse small intestineShinsuke Nakayama
Department of Cell Physiology, Nagoya University Graduate School of Medicine, Japan
Jpn J Physiol 52:217-27. 2002....
- Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefitsNana Ninagawa
Department of Health Sciences, Nagoya University Graduate School of Medicine, Higashi ku, Nagoya, Japan
Differentiation 82:153-64. 2011..They thus indicate a promising new source of cell-based therapy without teratoma formation...
- Switching of actin isoforms in skeletal muscle differentiation using mouse ES cellsYota Mizuno
Department of Physical Therapy, Nagoya University School of Health Sciences, Nagoya, Japan
Histochem Cell Biol 132:669-72. 2009..The exchange of isoforms is not directly linked to the sarcomere formation. As a result, ES cells provide a useful in vitro system for exploring skeletal muscle differentiation...
- Phagocytotic activation of muscularis resident macrophages inhibits smooth muscle contraction in rat ileumKoichi Sato
Laboratory of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan
J Vet Med Sci 69:1053-60. 2007..These results indicate that phagocytotic activation of muscularis resident macrophages induces COX-2 gene expression and then results in production of PGE2 to suppress the smooth muscle contractile activity...
- Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null ratToshihiko Suzuki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
Am J Physiol Gastrointest Liver Physiol 287:G638-46. 2004..Increased numbers and activation of macrophages may result in damage to ICC networks leading to disordered intestinal rhythmicity in regions of the gut in which myenteric ganglia are intact...
- [Genetic basis of autonomic gastrointestinal motility and pathophysiological models]Yoshiko Tokutomi
Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
Nihon Yakurigaku Zasshi 119:227-34. 2002..Here we review the genetic basis of autonomic gastrointestinal motility and the pathophysiological models...
- In vitro functional gut-like organ formation from mouse embryonic stem cellsTakatsugu Yamada
Division of Developmental Biology, Department of Parasitology, Nara Medical University, Nara, Japan
Stem Cells 20:41-9. 2002..The aim of the present study was to investigate the electrophysiological and morphological properties of ES cell-derived contracting clusters...