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Genomes and GenesSpecies | Yasuhito TanakaSummaryAffiliation: Nagoya City University Country: Japan Publications
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Publications
A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decadesYasuhito Tanaka
Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:15584-9. 2002..These estimates of viral spread time are consistent with epidemiologic observations and predict that the burden of HCC in the U.S. will increase in the next two to three decades, possibly to equal that currently experienced in Japan...
[Direct cytopathic effects of particular hepatitis B virus genotypes in immunosuppressive condition]Yasuhito Tanaka
Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Uirusu 60:79-86. 2010..Infection with HBV/C2 as well as PC mutant of the HBV/B1 in immunosuppressive conditions can induce direct cytopathic effect in "humanized" part of the murine liver...- [Evaluation of hepatitis B virus genotyping EIA kit]Yasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
Rinsho Byori 57:42-7. 2009..The EIA allowed genotyping even in HBV DNA negative samples (96.2%). In conclusion, HBV genotype EIA is reliable, sensitive and easy assay for HBV genotyping. The assay would be useful for clinical use... - Increasing genetic diversity of hepatitis C virus in haemophiliacs with human immunodeficiency virus coinfectionYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
J Gen Virol 88:2513-9. 2007..In conclusion, HIV-positive patients would have a more diversified HCV population than HIV-negative patients due to less selective pressure from the immune system... - Impact of interleukin-1beta genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in JapanYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Infect Dis 187:1822-5. 2003.... 
Interleukin28B and inosine triphosphatase help to personalize hepatitis C treatmentYasuhito Tanaka
Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
Digestion 84:50-5. 2011..These data may provide a valuable pharmacogenetic diagnostic tool for tailoring PEG-IFN/RBV dosing to minimize drug-induced adverse events and for further optimization of clinical anti-HCV chemotherapeutics...- Positive selection of core 70Q variant genotype 1b hepatitis C virus strains induced by pegylated interferon and ribavirinFuat Kurbanov
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Nagoya, Japan
J Infect Dis 201:1663-71. 2010..Mutations in the HCV core region were recently proposed to be associated with nonresponse. Our aim was to evaluate the viral factors associated with treatment failure... - Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytesMasaya Sugiyama
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Gastroenterology 136:652-62.e3. 2009..We investigate HBV genotype-related differences in viral replication, antigen expression, and histopathology in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mice harboring human hepatocytes... - Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinomaYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Hepatol 45:646-53. 2006..HBV/C subgenotypes have specific mutation patterns, which is probably responsible for increased carcinogenesis of HBV/C2/Ce... - Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infectionAtsushi Ozasa
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Hepatology 44:326-34. 2006.... - Eight genotypes (A-H) of hepatitis B virus infecting patients from San Francisco and their demographic, clinical, and virological characteristicsHideaki Kato
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Med Virol 73:516-21. 2004..HBV genotype H might be identified by combination of preS2 serotpe bksf and HBsAg serotype adw... - Classifying genotype F of hepatitis B virus into F1 and F2 subtypesHideaki Kato
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
World J Gastroenterol 11:6295-304. 2005..CONCLUSION: Based on these analyses, classifying HBV/F isolates into two subtypes (F1 and F2) would be more appropriate than providing them with two distinct genotypes (F and H)... - Genetic variability of hepatitis C virus in South Egypt and its possible clinical implicationAbeer Elkady
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
J Med Virol 81:1015-23. 2009..In conclusion, geographical diversity of HCV was revealed in this study in southern Egypt. A further case-control study is required to confirm the trends of differential pathogenicity of HCV subtypes, indicated by this study... - Epidemiological and clinical evaluation of hepatitis B, hepatitis C, and delta hepatitis viruses in TajikistanAnis Khan
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
J Med Virol 80:268-76. 2008..0004). This is the first study on the molecular epidemiology of hepatitis viruses among chronic liver diseases patients in Tajikistan. Among HBV-infected patients, the T1762/A1764 mutation was associated with liver cirrhosis/HCC... - Exponential spread of hepatitis C virus genotype 4a in EgyptYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Science, Kawasumi, Mizuho, Nagoya 467-8601, Japan
J Mol Evol 58:191-5. 2004..In conclusion, the estimated spread time is consistent with the duration of intravenous antimony campaigns in Egypt... - Variations in the viral NS5B region in Japanese patients with chronic hepatitis C virus genotype 1b infection. No specific amino acid substitution was identified as determinants of treatment response to interferon/ribavirin combination therapyKanji Sugihara
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, and Department of Gastroenterology, Nagoya Daini Red Cross Hospital, Japan
Intervirology 49:319-26. 2006.... - Virological and clinical implication of core promoter C1752/V1753 and T1764/G1766 mutations in hepatitis B virus genotype D infection in MongoliaAbeer Elkady
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Gastroenterol Hepatol 23:474-81. 2008..The aim of the present study was to reveal virological and clinical features of hepatitis B virus (HBV) genotype D infection... - Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2Noboru Shinkai
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
J Clin Microbiol 45:3191-7. 2007..37 [1.53 to 12.48], 7.98 [2.54 to 25.10], and 24.39 [8.11 to 73.33], respectively). Regardless of HBeAg status, the T1653 mutation increases the risk of HCC in Japanese patients with HBV/C2... - Comparison of complete sequences of hepatitis B virus genotype C between inactive carriers and hepatocellular carcinoma patients before and after seroconversionKiyoaki Ito
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
J Gastroenterol 42:837-44. 2007..The aim of this study was to investigate the HCC-related mutations of HBV... - A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae) and DYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Hepatology 40:747-55. 2004..In conclusion, the clearance of HBeAg from serum may occur by different mechanisms in HBV/Aa, HBV/Ae, and HBV/D infections, which may influence clinical manifestations in the Western countries where both genotypes A and D are prevalent... - Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytesYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467 8601 Japan
Virology 376:408-15. 2008..In conclusion, the replication of HBV/G can be enhanced remarkably when it is coinfected with HBV/H. Coinfection with HBV/G may be directly cytopathic in immunosuppressive conditions... - [Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay]Kentaro Matsuura
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya
Rinsho Byori 55:983-8. 2007..100% at W4), (100% vs. 100% at W8), (83.3% vs. 72.7% at W12). HCV RNA undetectable at W12 had a higher PPV for SVR when measured by RTD-PCR than by conventional PCR... - Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype EKei Fujiwara
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467-8601, Japan
World J Gastroenterol 11:6410-5. 2005..CONCLUSION: HBV/E is predominant in the Republic of Benin,and SC is estimated to occur in late teens in HBV/E.The specific nucleotide substitution G1757A in BCP,which might influence the virological characteristics, is observed in HBV/E... - Evaluation of anti-hepatitis E virus (HEV) immunoglobulin A in a serological screening for HEV infectionAbeer Elkady
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
J Gastroenterol 42:911-7. 2007..The present study was conducted to evaluate a novel anti-HEV serological kit based on detection of class A immunoglobulin antibody (anti-HEV IgA)... - A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in JapanAtsunori Kusakabe
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Aichi, 467 8601, Japan
J Gastroenterol 42:298-305. 2007..e., they constitute the so-called category of non-B non-C (NBNC) HCC. Little is known about the characteristics of NBNC-HCC... - Novel subtypes (subgenotypes) of hepatitis B virus genotypes B and C among chronic liver disease patients in the PhilippinesTomoyuki Sakamoto
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho, Nagoya 467-8601, Japan
J Gen Virol 87:1873-82. 2006..08; 95% CI 3.62-4.74; P<0.001) were significant factors for HCC development. In conclusion, novel HBV subtypes (subgenotypes) C5 and B5 are prevalent in the Philippines, as well as HBV/Aa (A1)... - Early dynamics of hepatitis B virus in chimeric mice carrying human hepatocytes monoinfected or coinfected with genotype GMasaya Sugiyama
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Hepatology 45:929-37. 2007..CONCLUSION: Genotype G can monoinfect chimeric mice at very low levels, and its replication increases maredly when coinfected with other genotypes. Coinfection with genotype G could enhance fibrosis under immunocompromised states... - Molecular epidemiology of hepatitis B virus in the United Republic of TanzaniaIzumi Hasegawa
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Med Virol 78:1035-42. 2006..The indicated tendency to early HBeAg seroconversion and declining of the viral load should be confirmed further in case-control studies... - Prognostic indicators of breakthrough hepatitis during lamivudine monotherapy for chronic hepatitis B virus infectionYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Medical School Graduate School of Sciences, Kawasumi 1, Mizuho, 467-8601 Nagoya, Japan
J Gastroenterol 39:769-75. 2004..CONCLUSIONS: These results suggest that patients with HBV pre-S deletion mutants should be monitored carefully during lamivudine therapy... - Novel type of hepatitis B virus mutation: replacement mutation involving a hepatocyte nuclear factor 1 binding site tandem repeat in chronic hepatitis B virus genotype EKei Fujiwara
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
J Virol 79:14404-10. 2005..This novel mutation may be specific to HBV genotype E, and its prevalence requires further investigation... - Molecular evolutionary analyses implicate injection treatment for schistosomiasis in the initial hepatitis C epidemics in JapanYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan
J Hepatol 42:47-53. 2005..CONCLUSIONS: The estimated spread time in previously Sj-endemic areas in Japan coincides with injection treatment for Sj since 1921. A high incidence of HCC there would be attributed to a long duration of HCV infection since 1920s... - Molecular epidemiology and interferon susceptibility of the natural recombinant hepatitis C virus strain RF1_2k/1bFuat Kurbanov
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Infect Dis 198:1448-56. 2008..Currently, there are no data available on the molecular epidemiology and interferon susceptibility of the natural intergenotypic recombinant RF1_2k/1b (RF1) strain... - Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis CYasuhito Tanaka
Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Hum Mol Genet 20:3507-16. 2011..Our present results may provide a valuable pharmacogenetic diagnostic tool for tailoring PEG-IFN/RBV dosing to minimize drug-induced adverse events... - Novel hepatitis B virus genotype a subtyping assay that distinguishes subtype Aa from Ae and its application in epidemiological studiesIzumi Hasegawa
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
J Virol 78:7575-81. 2004..In conclusion, the specificity and sensitivity of the combined subtyping assay were confirmed, and its usefulness was demonstrated in a practical context... - PCR-probe capture hybridization assay and statistical model for SEN virus prevalence estimationYasuhito Tanaka
Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, The National Institutes of Health, DHHS, Bethesda, Maryland, USA
J Med Virol 73:123-30. 2004.... - A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype JKanako Tatematsu
Department of Clinical Molecular Informative Medicine, Nagoya, City University Graduate School of Medical Sciences, Mizuho, Nagoya, Japan
J Virol 83:10538-47. 2009..Since HBV/J is positioned phylogenetically in between human and ape genotypes, it may help to trace the origin of HBV and merits further epidemiological surveys... - Abbott RealTime hepatitis C virus (HCV) and Roche Cobas AmpliPrep/Cobas TaqMan HCV assays for prediction of sustained virological response to pegylated interferon and ribavirin in chronic hepatitis C patientsKentaro Matsuura
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Clin Microbiol 47:385-9. 2009..HCV RNA tests using ART and CAP/CTM are considered to be more effective at predicting SVR than CAM, and the PPV for SVR was slightly higher in CAP/CTM than in ART... - Lack of association between occult hepatitis B virus DNA viral load and aminotransferase levels in patients with hepatitis C virus-related chronic liver diseaseKei Fujiwara
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Gastroenterol Hepatol 19:1343-7. 2004..CONCLUSIONS: The prevalence of occult HBV infection of HCV-related CLD is significantly higher than that of control. Occult HBV infection has no influence on ALT flares among patients with HCV-related CLD... - Epidemic spread of hepatitis C virus genotype 3a and relation to high incidence of hepatocellular carcinoma in PakistanAnis Khan
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
J Med Virol 81:1189-97. 2009..HCV-3a which spread earlier in Pakistan may be associated with an increasing incidence of HCC... - Mechanism of entecavir resistance of hepatitis B virus with viral breakthrough as determined by long-term clinical assessment and molecular docking simulationMotokazu Mukaide
Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, and Department of Gastroenterology, Nagoya Daini Red Cross Hospital, Nagoya 467 8601, Japan
Antimicrob Agents Chemother 54:882-9. 2010..5 A; -141 Kcal/mol). Our data suggest that the low binding affinity of ETV-TP for the HBV RT, involving conformational change of the binding pocket of HBV RT by L180M, M204V plus T184L, and S202G, could induce BT... - Virological and clinical characteristics on reactivation of occult hepatitis B in patients with hematological malignancyFuminaka Sugauchi
Department of Gastroenterology, Nagoya City Koseiin Medcial Welfare Center, Nagoya, Japan
J Med Virol 83:412-8. 2011..The fulminant outcome of HBV reactivation can be associated with genotype Bj exhibiting high replication due to the A1896 mutation... - A new subtype (subgenotype) Ac (A3) of hepatitis B virus and recombination between genotypes A and E in CameroonFuat Kurbanov
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan
J Gen Virol 86:2047-56. 2005..Further cohort studies will be required to assess detailed epidemiological, virological and clinical characteristics of HBV/Ac (A3), as well as its recombinant form... - [Clinical examinations based on nucleic acids of hepatitis viruses]Yasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya
Rinsho Byori 54:1164-71. 2006..Here, we summarize examinations based on viral nucleic acids and the clinical manifestations of HBV and HCV genotypes... - Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortalityYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Gastroenterology 130:703-14. 2006..CONCLUSIONS: These findings strongly suggest that the initial spread time of HCV is associated with the progression dynamics of HCC in each area, irrespective of genotype... - Two subtypes of genotype B (Ba and Bj) of hepatitis B virus in JapanFuminaka Sugauchi
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Clin Infect Dis 38:1222-8. 2004..01). The new method for distinguishing between Ba and Bj by restriction fragment-length polymorphism would be useful in examining the distribution of these 2 subtypes in situations in which HBV genotype B is prevalent... - Spread times of hepatitis C virus estimated by the molecular clock differ among Japan, the United States and Egypt in reflection of their distinct socioeconomic backgroundsMasashi Mizokami
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
Intervirology 49:28-36. 2006..These studies should help foresee what will happen in the near future for HCV infection in a given country, time the future development of HCC and take measures for preventing it... - Tracing the evolution of hepatitis C virus in the United States, Japan, and Egypt by using the molecular clockMasashi Mizokami
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Clin Gastroenterol Hepatol 3:S82-5. 2005.... - Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype AKentaro Matsuura
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
J Clin Microbiol 47:1476-83. 2009..The spread of HBV/A infection in Japan should be prevented by universal vaccination programs... - T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infectionKiyoaki Ito
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Clin Infect Dis 42:1-7. 2006..CONCLUSIONS: Our data indicate that the addition of T1653 mutation in the box alpha to the basic core promoter mutation increases the risk of hepatocellular carcinoma in patients with hepatitis B virus genotype C... - Investigating an outbreak of acute viral hepatitis caused by hepatitis E virus variants in Karachi, South PakistanAnis Khan
Department of Virology and Liver Unit, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
J Med Virol 83:622-9. 2011..This study cautions that the dissemination of the variant strains to other areas of Pakistan may lead to explosive HEV outbreaks... - Differences of hepatocellular carcinoma patients with hepatitis B virus genotypes of Ba, Bj or C in JapanEtsuro Orito
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi I, Mizuho, Nagoya 467-8601, Japan
Intervirology 48:239-45. 2005..5% of those aged older than 50 years had cirrhosis. These data suggest that great differences exist among patients with HCC infected with different genotypes... - Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigensMasaya Sugiyama
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Hepatology 44:915-24. 2006..In conclusion, virological differences among HBV genotypes were demonstrated both in vitro and in vivo. These differences may influence HBV infections with distinct genotypes in clinical and epidemiological settings... - Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype AFuminaka Sugauchi
Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Gen Virol 85:811-20. 2004..Subtypes Aa and Ae of genotype A deserve evaluation for any clinical differences between them, with a special reference to hepatocellular carcinoma prevalent in Africa... - [Evaluation of serum PIVKA-II by Lumipulse PrestoII assay]Kumiko Hiramatsu
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
Rinsho Byori 57:200-5. 2009..In conclusion, the PrestoII assay, which applies the inactive ALP with high activity, is reliable and useful for clinical screening... - Development of new IL28B genotyping method using Invader Plus assaySatomi Kani
Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Japan
Microbiol Immunol 56:318-23. 2012..3%, and that of non-responders in the minor heterozygous/homozygous type was 72.5%. A convenient IL28B genotyping method using the Invader Plus assay could be useful to predict the treatment outcome in clinical practice... - [Evaluation and application of a newly developed highly sensitive HBsAg chemiluminescent enzyme immunoassay for chronic hepatitis B patients]Noboru Shinkai
Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
Rinsho Byori 58:1078-84. 2010..We modified and automated Matsubara's techniques. Our aim is to evaluate the fundamental performance of our assay (prototype) and to investigate the clinical significance of prototype in patients with hepatitis B virus (HBV) infection... - Transforming growth factor-beta-1 genetic polymorphism in Japanese patients with chronic hepatitis C virus infectionSeiji Suzuki
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Gastroenterol Hepatol 18:1139-43. 2003..The aim of the present study was to examine the effects of TGF-beta1 polymorphisms in Japanese patients with chronic hepatitis C virus (HCV) infection and in healthy control subjects... - [Evaluation of high-sensitivity HBsAg quantitative assay for HBV genotype]Kazumi Takagi
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
Rinsho Byori 57:638-43. 2009..Monitoring of serum HBsAg concentrations in addition to HBV DNA quantification, is helpful in evaluation of the response or resistance to anti-viral therapy... - Evaluation of loss of heterozygosity before and after interferon therapy in patients with hepatitis C virus infection who developed hepatocellular carcinoma during follow upSeiji Suzuki
Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Gastroenterol Hepatol 18:1364-72. 2003..The authors propose that the status of LOH in chronic hepatitis and liver cirrhosis patients before IFN therapy could be a potential predictor for the development of HCC... - Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis CYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Nat Genet 41:1105-9. 2009..52 x 10(-28)-2.68 x 10(-32); OR = 22.3-27.1). Real-time quantitative PCR assays in peripheral blood mononuclear cells showed lower IL28B expression levels in individuals carrying the minor alleles (P = 0.015)... - Performance of two Real-Time RT-PCR assays for quantitation of hepatitis C virus RNA: evaluation on HCV genotypes 1-4Abeer Elkady
Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
J Med Virol 82:1878-88. 2010..5 IU/ml using the WHO standards, respectively. In conclusion, two RT-PCR assays had a high efficiency and accuracy for quantitation of HCV RNA of genotypes 2a, 2b, and 3a, but the mean values of HCV RNA differed for genotype 1b and 4... - New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0Motokazu Mukaide
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Science, Kawasumi, Mizuho, Nagoya 467-8601, Japan
World J Gastroenterol 11:469-75. 2005..The HCV Guideline test is a useful method for screening large cohorts in a routine clinical setting for determining the treatment regimen and for predicting the outcome of antiviral therapy of chronic hepatitis C... - A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in JapanAtsunori Kusakabe
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Gastroenterol 46:117-24. 2011.... - Virological features of hepatitis B virus-associated nephropathy in JapanAtsunori Kusakabe
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Med Virol 79:1305-11. 2007..Only one patient had core deletions. It is concluded that HBV/A may be associated with membranous nephropathy, but little relationship between HBV gene mutations and the development of HBV-associated nephropathy was observed... - Influences on hepatitis B virus replication by a naturally occurring mutation in the core geneMasaya Sugiyama
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
Virology 365:285-91. 2007..In conclusion, the A2339G mutation was considered as one of the viral factors involved in high replication efficiency... - Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populationsTomoyuki Sakamoto
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Infect Dis 196:1487-92. 2007..The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types... - Predicting relapse after cessation of Lamivudine monotherapy for chronic hepatitis B virus infectionKiyoaki Ito
Department of Gastroenterology, Chukyo Hospital, Nagoya, Japan
Clin Infect Dis 38:490-5. 2004..27-0.9). More-prolonged lamivudine therapy is required after seroconversion, and persistent duration of an HBV DNA level of <0.7 log IU/mL for >6 months can more accurately aid in the decision of when to stop lamivudine therapy... - Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinomaTomoyoshi Ohno
Department of Gastroenterology, Social Insurance Chukyo Hospital, Nagoya, Japan
Hepatol Res 37:276-85. 2007..Conclusions: In HCV-positive HCC patients, CTL inductivity by dendritic cells is impaired. This may be related to the impaired production of IFN-gamma... - Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in BoliviaAnis Khan
Department of Clinical Molecular Informative Medicine, Nagoya City University, Mizuho, Nagoya 467 8601, Japan
Virus Res 132:174-80. 2008..This report provides evidence of an inter-communities transmission of HBV revealed by its genotypes. Further study is required to investigate peculiarities of the genotypes in different ethnic groups in Bolivia... - Human immunodeficiency virus in Uzbekistan: epidemiological and genetic analysesFuat Kurbanov
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
AIDS Res Hum Retroviruses 19:731-8. 2003..However, the current study demonstrates a substantially increasing number of new infections, in association with IVDU, and an exponentially growing effective population size of the IVDU-associated HIV strain... - Molecular evolutionary analysis predicts the incidence of hepatocellular carcinoma in the United States and JapanMasashi Mizokami
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
Cancer Chemother Pharmacol 54:S83-6. 2004..If HCC is a function of increased HCV exposure time, the molecular clock predicts that the burden of HCC in the US will accelerate in the next two to three decades... - [Nucleic acid-based testing for hepatitis B viruss infectious disease]Yasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences
Nippon Rinsho 63:331-7. 2005 - Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphomaShigeru Kusumoto
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
Int J Hematol 90:13-23. 2009..In this review, we summarize the characteristics of HBV reactivation after systemic chemotherapy including rituximab, and propose a management strategy for malignant lymphoma patients suffering from HBV reactivation... - Hepatitis C virus molecular epidemiology in UzbekistanFuat Kurbanov
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Med Virol 69:367-75. 2003.... - [Clinical manifestations of hepatitis B virus genotypes]Yasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences
Nippon Rinsho 62:293-8. 2004 - [HBV--clinical impact of HBV genotypes]Yasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences
Nippon Rinsho 61:621-6. 2003 - Genotypes and phylogenetic characterization of hepatitis B and delta viruses in EgyptNiveen Saudy
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Med Virol 70:529-36. 2003..These results indicate that HBV genotype D and HDV genotype I are most prevalent in Egypt, and HDV co-infection in HBV carriers is related to severity of liver disease... - Interleukin 1beta gene polymorphism and hepatitis C virus-related hepatocellular carcinomaAnthony E T Yeo
Hepatology 38:267-8; author reply 268-9. 2003 - Clinical and virological characteristics of hepatitis B virus subgenotypes Ba, C1, and C2 in ChinaZhanhui Wang
Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
J Clin Microbiol 45:1491-6. 2007..Therefore, genotyping and detecting the 1653T and 1753V mutations, in addition to the A1762T G1764A double mutation, might have important clinical implications as predictive risk factors for hepatocarcinogenesis... - Comparison of genotypes C and D of the hepatitis B virus in Japan: a clinical and molecular biological studyTran Nhu Duong
Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
J Med Virol 72:551-7. 2004..Thus, the outcome of chronic HBV infection may be different in persons infected with HBV genotypes C and D... - What can be revealed by extending the sensitivity of HBsAg detection to below the present limit?Hitoshi Togashi
Department of Gastroenterology, Course of Internal Medicine and Therapeutics, Yamagata University Faculty of Medicine, Yamagata University Health Administration Center, 1 4 12 Kojirakawa machi, Yamagata 990 8560, Japan
J Hepatol 49:17-24. 2008..We investigated what can be revealed by extending the sensitivity of HBsAg detection to below the present limit... - Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control studyMan-Fung Yuen
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
Carcinogenesis 25:1593-8. 2004..The association between HBV genotype C and HCC was probably not genuine but was due to the high percentage of CP mutations in patients with genotype C... - Reliability of hepatitis C virus core antigen assay for detection of viremia in HCV genotypes 1, 2, 3, and 4 infected blood donors: a collaborative study between Japan, Egypt, and UzbekistanSalah Agha
Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
J Med Virol 73:216-22. 2004..No specific mutation was found in the core-encoding region of the studied specimens. In conclusion, HCVcAg is shown to be specific, sensitive, and informative qualitative index for HCV viremia in asymptomatic carriers... - Variations in the core promoter/pre-core region in HBV genotype C in Japanese and Northern Vietnamese patientsBui Xuan Truong
Kobe University Graduate School of Medicine, Clinical Molecular Medicine, Kobe, Japan
J Med Virol 79:1293-304. 2007..The subgenotypes and unique mutations of HBV genotype C in the Vietnamese and Japanese differed, and C/A1753 and C1858 variants might play a role in the pathogenesis of liver disease in Vietnamese patients... - Molecular evolution of hepatitis B virus over 25 yearsCarla Osiowy
Public Health Agency of Canada, National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba R3E 3P6, Canada
J Virol 80:10307-14. 2006..The results of this study suggest that HBV sequence divergence may occur more rapidly than previously estimated, in a host immune phase-dependent manner... - Molecular epidemiological study of hepatitis B virus infection in two different ethnic populations from the Solomon IslandsTakako Utsumi
Department of International and Environmental Medical Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
J Med Virol 79:229-35. 2007..HBeAg appears to clear from the serum in young adulthood in HBV/D infection, which may be influenced by genotype-dependent features in relation to viral mutations... - A reduction in selective immune pressure during the course of chronic hepatitis C correlates with diminished biochemical evidence of hepatic inflammationKousuke Hanada
National Institute of Genetics, Yata 1111, Mishima, Shizuoka, Japan
Virology 361:27-33. 2007..This observation may be applicable to other viruses characterized by a slow rate of disease progression... - High frequency of hepatocellular carcinoma in Mongolia; association with mono-, or co-infection with hepatitis C, B, and delta virusesTsendsuren Oyunsuren
Laboratory of Molecular Biology, The Institute of Biology, Mongolian Academy of Sciences, Ulaanbaatar, Mongolia
J Med Virol 78:1688-95. 2006..Liver tumor markers; AFP and PIVKA-II are useful tools for complex HCC-screening and clinical follow-up for chronic hepatitis patients in Mongolia... - Hepatitis B virus transmission pattern and vaccination efficiency in UzbekistanDildora Avazova
National Reference Laboratory, Ministry of Public Health, Tashkent, Uzbekistan
J Med Virol 80:217-24. 2008..In conclusion, HBV universal vaccination is efficient in Uzbekistan irrespective of the vaccine formulation used, because the horizontal transmission pattern predominates currently in this endemic region... - Hepatitis B virus (HBV) genotypes/subgenotypes in China: mutations in core promoter and precore/core and their clinical implicationsJing Yuan
Shenzhen East Lake Hospital, Shenzhen, China
J Clin Virol 39:87-93. 2007..The association of hepatitis B virus (HBV) genotypes with clinical course of infection is increasingly recognized... - Impact of occult hepatitis B virus infection on efficacy and prognosis of interferon-alpha therapy for patients with chronic hepatitis CIzumi Hasegawa
Department of Internal Medicine, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467-8601, Japan
Liver Int 25:247-53. 2005..CONCLUSIONS: Occult HBV infection may not have a significant impact on response to IFN therapy for chronic HCV and development of HCC after therapy. Occult HBV may be sensitive to IFN although HBV is not completely eradicated... - When should "I" consider a new hepatitis B virus genotype?Fuat Kurbanov
J Virol 82:8241-2. 2008 - Analysis of HCV genotypes from blood donors shows three new HCV type 6 subgroups exist in MyanmarToshiyuki Shinji
Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
Acta Med Okayama 58:135-42. 2004..M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed... - Tracing the history of hepatitis B virus genotype D in western JapanKojiro Michitaka
Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
J Med Virol 78:44-52. 2006..From the history of the area and the genetic analysis, HBV/D in this area was speculated to be of Russian origin... - [Epidemiology of intrafamilial transmission of hepatitis C virus by molecular evolutionary analysis]Izumi Hasegawa
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences
Nippon Rinsho 62:291-5. 2004 - Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong KongMan-Fung Yuen
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China
J Hepatol 41:119-25. 2004..The former had a higher chance of earlier HBeAg seroconversion and lower ALT levels. The prevalence of genotype B was lower in patients with age <50, probably related to influx of immigrants from China since 1949... - Molecular tracing of Japan-indigenous hepatitis E virusesYasuhito Tanaka
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan
J Gen Virol 87:949-54. 2006..In conclusion, these data suggest that the indigenization and spread of HEV in Japan were associated with the popularization of eating pork...