Yasuhito Tanaka

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. pmc A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades
    Yasuhito Tanaka
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:15584-9. 2002
  2. ncbi request reprint [Evaluation of hepatitis B virus genotyping EIA kit]
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Rinsho Byori 57:42-7. 2009
  3. ncbi request reprint [Direct cytopathic effects of particular hepatitis B virus genotypes in immunosuppressive condition]
    Yasuhito Tanaka
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Uirusu 60:79-86. 2010
  4. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
  5. doi request reprint Interleukin28B and inosine triphosphatase help to personalize hepatitis C treatment
    Yasuhito Tanaka
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
    Digestion 84:50-5. 2011
  6. ncbi request reprint Impact of interleukin-1beta genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Infect Dis 187:1822-5. 2003
  7. ncbi request reprint Increasing genetic diversity of hepatitis C virus in haemophiliacs with human immunodeficiency virus coinfection
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Gen Virol 88:2513-9. 2007
  8. doi request reprint Positive selection of core 70Q variant genotype 1b hepatitis C virus strains induced by pegylated interferon and ribavirin
    Fuat Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Nagoya, Japan
    J Infect Dis 201:1663-71. 2010
  9. ncbi request reprint Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection
    Atsushi Ozasa
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatology 44:326-34. 2006
  10. doi request reprint Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes
    Masaya Sugiyama
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Gastroenterology 136:652-62.e3. 2009

Detail Information

Publications99

  1. pmc A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades
    Yasuhito Tanaka
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:15584-9. 2002
    ..These estimates of viral spread time are consistent with epidemiologic observations and predict that the burden of HCC in the U.S. will increase in the next two to three decades, possibly to equal that currently experienced in Japan...
  2. ncbi request reprint [Evaluation of hepatitis B virus genotyping EIA kit]
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Rinsho Byori 57:42-7. 2009
    ..The EIA allowed genotyping even in HBV DNA negative samples (96.2%). In conclusion, HBV genotype EIA is reliable, sensitive and easy assay for HBV genotyping. The assay would be useful for clinical use...
  3. ncbi request reprint [Direct cytopathic effects of particular hepatitis B virus genotypes in immunosuppressive condition]
    Yasuhito Tanaka
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Uirusu 60:79-86. 2010
    ..Infection with HBV/C2 as well as PC mutant of the HBV/B1 in immunosuppressive conditions can induce direct cytopathic effect in "humanized" part of the murine liver...
  4. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
    ....
  5. doi request reprint Interleukin28B and inosine triphosphatase help to personalize hepatitis C treatment
    Yasuhito Tanaka
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
    Digestion 84:50-5. 2011
    ..These data may provide a valuable pharmacogenetic diagnostic tool for tailoring PEG-IFN/RBV dosing to minimize drug-induced adverse events and for further optimization of clinical anti-HCV chemotherapeutics...
  6. ncbi request reprint Impact of interleukin-1beta genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Infect Dis 187:1822-5. 2003
    ....
  7. ncbi request reprint Increasing genetic diversity of hepatitis C virus in haemophiliacs with human immunodeficiency virus coinfection
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Gen Virol 88:2513-9. 2007
    ..In conclusion, HIV-positive patients would have a more diversified HCV population than HIV-negative patients due to less selective pressure from the immune system...
  8. doi request reprint Positive selection of core 70Q variant genotype 1b hepatitis C virus strains induced by pegylated interferon and ribavirin
    Fuat Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Nagoya, Japan
    J Infect Dis 201:1663-71. 2010
    ..Mutations in the HCV core region were recently proposed to be associated with nonresponse. Our aim was to evaluate the viral factors associated with treatment failure...
  9. ncbi request reprint Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection
    Atsushi Ozasa
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatology 44:326-34. 2006
    ....
  10. doi request reprint Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes
    Masaya Sugiyama
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Gastroenterology 136:652-62.e3. 2009
    ..We investigate HBV genotype-related differences in viral replication, antigen expression, and histopathology in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mice harboring human hepatocytes...
  11. ncbi request reprint Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Hepatol 45:646-53. 2006
    ..Hepatitis B virus genotype C (HBV/C) has been classified into two geographically distinct subgenotypes; HBV/C1/Cs (Southeast Asia) and HBV/C2/Ce (East Asia)...
  12. ncbi request reprint Impact of occult hepatitis B virus infection on efficacy and prognosis of interferon-alpha therapy for patients with chronic hepatitis C
    Izumi Hasegawa
    Department of Internal Medicine, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Liver Int 25:247-53. 2005
    ..The aim of this study was to elucidate the impact of occult HBV infection on the efficacy and prognosis of interferon-alpha (IFN) therapy in HCV patients...
  13. ncbi request reprint Epidemiological and clinical evaluation of hepatitis B, hepatitis C, and delta hepatitis viruses in Tajikistan
    Anis Khan
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
    J Med Virol 80:268-76. 2008
    ..0004). This is the first study on the molecular epidemiology of hepatitis viruses among chronic liver diseases patients in Tajikistan. Among HBV-infected patients, the T1762/A1764 mutation was associated with liver cirrhosis/HCC...
  14. ncbi request reprint Classifying genotype F of hepatitis B virus into F1 and F2 subtypes
    Hideaki Kato
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    World J Gastroenterol 11:6295-304. 2005
    ..To explore the propriety of providing hepatitis B virus (HBV) genotypes F and H with two distinct genotypes...
  15. ncbi request reprint [Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay]
    Kentaro Matsuura
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya
    Rinsho Byori 55:983-8. 2007
    ..100% at W4), (100% vs. 100% at W8), (83.3% vs. 72.7% at W12). HCV RNA undetectable at W12 had a higher PPV for SVR when measured by RTD-PCR than by conventional PCR...
  16. doi request reprint Genetic variability of hepatitis C virus in South Egypt and its possible clinical implication
    Abeer Elkady
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
    J Med Virol 81:1015-23. 2009
    ..In conclusion, geographical diversity of HCV was revealed in this study in southern Egypt. A further case-control study is required to confirm the trends of differential pathogenicity of HCV subtypes, indicated by this study...
  17. ncbi request reprint Exponential spread of hepatitis C virus genotype 4a in Egypt
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Science, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Mol Evol 58:191-5. 2004
    ..In conclusion, the estimated spread time is consistent with the duration of intravenous antimony campaigns in Egypt...
  18. ncbi request reprint Eight genotypes (A-H) of hepatitis B virus infecting patients from San Francisco and their demographic, clinical, and virological characteristics
    Hideaki Kato
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 73:516-21. 2004
    ..HBV genotype H might be identified by combination of preS2 serotpe bksf and HBsAg serotype adw...
  19. doi request reprint Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467 8601 Japan
    Virology 376:408-15. 2008
    ..In conclusion, the replication of HBV/G can be enhanced remarkably when it is coinfected with HBV/H. Coinfection with HBV/G may be directly cytopathic in immunosuppressive conditions...
  20. doi request reprint Virological and clinical implication of core promoter C1752/V1753 and T1764/G1766 mutations in hepatitis B virus genotype D infection in Mongolia
    Abeer Elkady
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 23:474-81. 2008
    ..The aim of the present study was to reveal virological and clinical features of hepatitis B virus (HBV) genotype D infection...
  21. ncbi request reprint Comparison of complete sequences of hepatitis B virus genotype C between inactive carriers and hepatocellular carcinoma patients before and after seroconversion
    Kiyoaki Ito
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Gastroenterol 42:837-44. 2007
    ..The aim of this study was to investigate the HCC-related mutations of HBV...
  22. ncbi request reprint A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae) and D
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatology 40:747-55. 2004
    ..In conclusion, the clearance of HBeAg from serum may occur by different mechanisms in HBV/Aa, HBV/Ae, and HBV/D infections, which may influence clinical manifestations in the Western countries where both genotypes A and D are prevalent...
  23. pmc Mechanism of entecavir resistance of hepatitis B virus with viral breakthrough as determined by long-term clinical assessment and molecular docking simulation
    Motokazu Mukaide
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, and Department of Gastroenterology, Nagoya Daini Red Cross Hospital, Nagoya 467 8601, Japan
    Antimicrob Agents Chemother 54:882-9. 2010
    ..5 A; -141 Kcal/mol). Our data suggest that the low binding affinity of ETV-TP for the HBV RT, involving conformational change of the binding pocket of HBV RT by L180M, M204V plus T184L, and S202G, could induce BT...
  24. pmc Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2
    Noboru Shinkai
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Clin Microbiol 45:3191-7. 2007
    ..37 [1.53 to 12.48], 7.98 [2.54 to 25.10], and 24.39 [8.11 to 73.33], respectively). Regardless of HBeAg status, the T1653 mutation increases the risk of HCC in Japanese patients with HBV/C2...
  25. pmc Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A
    Kentaro Matsuura
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
    J Clin Microbiol 47:1476-83. 2009
    ..The spread of HBV/A infection in Japan should be prevented by universal vaccination programs...
  26. pmc Abbott RealTime hepatitis C virus (HCV) and Roche Cobas AmpliPrep/Cobas TaqMan HCV assays for prediction of sustained virological response to pegylated interferon and ribavirin in chronic hepatitis C patients
    Kentaro Matsuura
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Clin Microbiol 47:385-9. 2009
    ..HCV RNA tests using ART and CAP/CTM are considered to be more effective at predicting SVR than CAM, and the PPV for SVR was slightly higher in CAP/CTM than in ART...
  27. ncbi request reprint Variations in the viral NS5B region in Japanese patients with chronic hepatitis C virus genotype 1b infection. No specific amino acid substitution was identified as determinants of treatment response to interferon/ribavirin combination therapy
    Kanji Sugihara
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, and Department of Gastroenterology, Nagoya Daini Red Cross Hospital, Japan
    Intervirology 49:319-26. 2006
    ....
  28. ncbi request reprint Novel subtypes (subgenotypes) of hepatitis B virus genotypes B and C among chronic liver disease patients in the Philippines
    Tomoyuki Sakamoto
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho, Nagoya 467 8601, Japan
    J Gen Virol 87:1873-82. 2006
    ..08; 95% CI 3.62-4.74; P<0.001) were significant factors for HCC development. In conclusion, novel HBV subtypes (subgenotypes) C5 and B5 are prevalent in the Philippines, as well as HBV/Aa (A1)...
  29. doi request reprint Molecular epidemiology and interferon susceptibility of the natural recombinant hepatitis C virus strain RF1_2k/1b
    Fuat Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Infect Dis 198:1448-56. 2008
    ..Currently, there are no data available on the molecular epidemiology and interferon susceptibility of the natural intergenotypic recombinant RF1_2k/1b (RF1) strain...
  30. ncbi request reprint Early dynamics of hepatitis B virus in chimeric mice carrying human hepatocytes monoinfected or coinfected with genotype G
    Masaya Sugiyama
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatology 45:929-37. 2007
    ..CONCLUSION: Genotype G can monoinfect chimeric mice at very low levels, and its replication increases maredly when coinfected with other genotypes. Coinfection with genotype G could enhance fibrosis under immunocompromised states...
  31. ncbi request reprint A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan
    Atsunori Kusakabe
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Aichi, 467 8601, Japan
    J Gastroenterol 42:298-305. 2007
    ..e., they constitute the so-called category of non-B non-C (NBNC) HCC. Little is known about the characteristics of NBNC-HCC...
  32. ncbi request reprint Evaluation of anti-hepatitis E virus (HEV) immunoglobulin A in a serological screening for HEV infection
    Abeer Elkady
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
    J Gastroenterol 42:911-7. 2007
    ..The present study was conducted to evaluate a novel anti-HEV serological kit based on detection of class A immunoglobulin antibody (anti-HEV IgA)...
  33. pmc Novel type of hepatitis B virus mutation: replacement mutation involving a hepatocyte nuclear factor 1 binding site tandem repeat in chronic hepatitis B virus genotype E
    Kei Fujiwara
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Virol 79:14404-10. 2005
    ..This novel mutation may be specific to HBV genotype E, and its prevalence requires further investigation...
  34. ncbi request reprint Molecular evolutionary analyses implicate injection treatment for schistosomiasis in the initial hepatitis C epidemics in Japan
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Hepatol 42:47-53. 2005
    ..Our aim was to estimate the spread time of hepatitis C virus (HCV) infection in the past with possible relevance to a higher incidence of HCC in once Sj-endemic than Sj-nonendemic areas...
  35. ncbi request reprint Prognostic indicators of breakthrough hepatitis during lamivudine monotherapy for chronic hepatitis B virus infection
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Medical School Graduate School of Sciences, Kawasumi 1, Mizuho, 467 8601 Nagoya, Japan
    J Gastroenterol 39:769-75. 2004
    ..There have been many reports of lamivudine-resistant mutations within the C domain of the viral reverse transcriptase; however, the appearance of these mutants is not necessarily correlated with BTH during lamivudine therapy...
  36. pmc Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene
    Tsunamasa Watanabe
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Gut 62:1340-6. 2013
    ..However, it is unclear whether genetic variations near the IL28B gene influence hepatic interferon (IFN)-stimulated gene (ISG) induction or cellular immune responses, lead to the viral reduction during IFN treatment...
  37. ncbi request reprint [Clinical examinations based on nucleic acids of hepatitis viruses]
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya
    Rinsho Byori 54:1164-71. 2006
    ..Here, we summarize examinations based on viral nucleic acids and the clinical manifestations of HBV and HCV genotypes...
  38. ncbi request reprint Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E
    Kei Fujiwara
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
    World J Gastroenterol 11:6410-5. 2005
    ..To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype...
  39. ncbi request reprint T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection
    Kiyoaki Ito
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Infect Dis 42:1-7. 2006
    ....
  40. ncbi request reprint Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens
    Masaya Sugiyama
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatology 44:915-24. 2006
    ..In conclusion, virological differences among HBV genotypes were demonstrated both in vitro and in vivo. These differences may influence HBV infections with distinct genotypes in clinical and epidemiological settings...
  41. doi request reprint Epidemic spread of hepatitis C virus genotype 3a and relation to high incidence of hepatocellular carcinoma in Pakistan
    Anis Khan
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
    J Med Virol 81:1189-97. 2009
    ..HCV-3a which spread earlier in Pakistan may be associated with an increasing incidence of HCC...
  42. ncbi request reprint PCR-probe capture hybridization assay and statistical model for SEN virus prevalence estimation
    Yasuhito Tanaka
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, The National Institutes of Health, DHHS, Bethesda, Maryland, USA
    J Med Virol 73:123-30. 2004
    ....
  43. pmc A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J
    Kanako Tatematsu
    Department of Clinical Molecular Informative Medicine, Nagoya, City University Graduate School of Medical Sciences, Mizuho, Nagoya, Japan
    J Virol 83:10538-47. 2009
    ..Since HBV/J is positioned phylogenetically in between human and ape genotypes, it may help to trace the origin of HBV and merits further epidemiological surveys...
  44. pmc Novel hepatitis B virus genotype a subtyping assay that distinguishes subtype Aa from Ae and its application in epidemiological studies
    Izumi Hasegawa
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Virol 78:7575-81. 2004
    ..In conclusion, the specificity and sensitivity of the combined subtyping assay were confirmed, and its usefulness was demonstrated in a practical context...
  45. doi request reprint Virological and clinical characteristics on reactivation of occult hepatitis B in patients with hematological malignancy
    Fuminaka Sugauchi
    Department of Gastroenterology, Nagoya City Koseiin Medcial Welfare Center, Nagoya, Japan
    J Med Virol 83:412-8. 2011
    ..The fulminant outcome of HBV reactivation can be associated with genotype Bj exhibiting high replication due to the A1896 mutation...
  46. ncbi request reprint Lack of association between occult hepatitis B virus DNA viral load and aminotransferase levels in patients with hepatitis C virus-related chronic liver disease
    Kei Fujiwara
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 19:1343-7. 2004
    ..To elucidate the correlation between occult HBV infection and the clinical course of HCV-related CLD, we evaluated whether the fluctuation of occult HBV-DNA directly affects the serum alanine aminotransferase (ALT) level...
  47. ncbi request reprint Molecular epidemiology of hepatitis B virus in the United Republic of Tanzania
    Izumi Hasegawa
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 78:1035-42. 2006
    ..The indicated tendency to early HBeAg seroconversion and declining of the viral load should be confirmed further in case-control studies...
  48. ncbi request reprint A new subtype (subgenotype) Ac (A3) of hepatitis B virus and recombination between genotypes A and E in Cameroon
    Fuat Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Gen Virol 86:2047-56. 2005
    ..Further cohort studies will be required to assess detailed epidemiological, virological and clinical characteristics of HBV/Ac (A3), as well as its recombinant form...
  49. doi request reprint Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hum Mol Genet 20:3507-16. 2011
    ..Our present results may provide a valuable pharmacogenetic diagnostic tool for tailoring PEG-IFN/RBV dosing to minimize drug-induced adverse events...
  50. ncbi request reprint Tracing the evolution of hepatitis C virus in the United States, Japan, and Egypt by using the molecular clock
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Gastroenterol Hepatol 3:S82-5. 2005
    ....
  51. ncbi request reprint Spread times of hepatitis C virus estimated by the molecular clock differ among Japan, the United States and Egypt in reflection of their distinct socioeconomic backgrounds
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Intervirology 49:28-36. 2006
    ..These studies should help foresee what will happen in the near future for HCV infection in a given country, time the future development of HCC and take measures for preventing it...
  52. doi request reprint Investigating an outbreak of acute viral hepatitis caused by hepatitis E virus variants in Karachi, South Pakistan
    Anis Khan
    Department of Virology and Liver Unit, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 83:622-9. 2011
    ..This study cautions that the dissemination of the variant strains to other areas of Pakistan may lead to explosive HEV outbreaks...
  53. ncbi request reprint [Evaluation of serum PIVKA-II by Lumipulse PrestoII assay]
    Kumiko Hiramatsu
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Rinsho Byori 57:200-5. 2009
    ..In conclusion, the PrestoII assay, which applies the inactive ALP with high activity, is reliable and useful for clinical screening...
  54. ncbi request reprint Differences of hepatocellular carcinoma patients with hepatitis B virus genotypes of Ba, Bj or C in Japan
    Etsuro Orito
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi I, Mizuho, Nagoya 467 8601, Japan
    Intervirology 48:239-45. 2005
    ..5% of those aged older than 50 years had cirrhosis. These data suggest that great differences exist among patients with HCC infected with different genotypes...
  55. doi request reprint Performance of two Real-Time RT-PCR assays for quantitation of hepatitis C virus RNA: evaluation on HCV genotypes 1-4
    Abeer Elkady
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
    J Med Virol 82:1878-88. 2010
    ..5 IU/ml using the WHO standards, respectively. In conclusion, two RT-PCR assays had a high efficiency and accuracy for quantitation of HCV RNA of genotypes 2a, 2b, and 3a, but the mean values of HCV RNA differed for genotype 1b and 4...
  56. doi request reprint Development of new IL28B genotyping method using Invader Plus assay
    Satomi Kani
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Japan
    Microbiol Immunol 56:318-23. 2012
    ..3%, and that of non-responders in the minor heterozygous/homozygous type was 72.5%. A convenient IL28B genotyping method using the Invader Plus assay could be useful to predict the treatment outcome in clinical practice...
  57. ncbi request reprint Transforming growth factor-beta-1 genetic polymorphism in Japanese patients with chronic hepatitis C virus infection
    Seiji Suzuki
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 18:1139-43. 2003
    ..The aim of the present study was to examine the effects of TGF-beta1 polymorphisms in Japanese patients with chronic hepatitis C virus (HCV) infection and in healthy control subjects...
  58. ncbi request reprint [Evaluation and application of a newly developed highly sensitive HBsAg chemiluminescent enzyme immunoassay for chronic hepatitis B patients]
    Noboru Shinkai
    Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Rinsho Byori 58:1078-84. 2010
    ..We modified and automated Matsubara's techniques. Our aim is to evaluate the fundamental performance of our assay (prototype) and to investigate the clinical significance of prototype in patients with hepatitis B virus (HBV) infection...
  59. ncbi request reprint [Evaluation of high-sensitivity HBsAg quantitative assay for HBV genotype]
    Kazumi Takagi
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Rinsho Byori 57:638-43. 2009
    ..Monitoring of serum HBsAg concentrations in addition to HBV DNA quantification, is helpful in evaluation of the response or resistance to anti-viral therapy...
  60. ncbi request reprint Two subtypes of genotype B (Ba and Bj) of hepatitis B virus in Japan
    Fuminaka Sugauchi
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Infect Dis 38:1222-8. 2004
    ..01). The new method for distinguishing between Ba and Bj by restriction fragment-length polymorphism would be useful in examining the distribution of these 2 subtypes in situations in which HBV genotype B is prevalent...
  61. ncbi request reprint Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Gastroenterology 130:703-14. 2006
    ..This approach was combined with analyses of the hepatitis C virus (HCV) epidemiologic-historical background and HCV-related hepatocellular carcinoma (HCC) in different countries...
  62. ncbi request reprint Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype A
    Fuminaka Sugauchi
    Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gen Virol 85:811-20. 2004
    ..Subtypes Aa and Ae of genotype A deserve evaluation for any clinical differences between them, with a special reference to hepatocellular carcinoma prevalent in Africa...
  63. doi request reprint Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nat Genet 41:1105-9. 2009
    ..52 x 10(-28)-2.68 x 10(-32); OR = 22.3-27.1). Real-time quantitative PCR assays in peripheral blood mononuclear cells showed lower IL28B expression levels in individuals carrying the minor alleles (P = 0.015)...
  64. ncbi request reprint Evaluation of loss of heterozygosity before and after interferon therapy in patients with hepatitis C virus infection who developed hepatocellular carcinoma during follow up
    Seiji Suzuki
    Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 18:1364-72. 2003
    ....
  65. ncbi request reprint Influences on hepatitis B virus replication by a naturally occurring mutation in the core gene
    Masaya Sugiyama
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Virology 365:285-91. 2007
    ..In conclusion, the A2339G mutation was considered as one of the viral factors involved in high replication efficiency...
  66. ncbi request reprint New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0
    Motokazu Mukaide
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Science, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    World J Gastroenterol 11:469-75. 2005
    ..0 (microwell version)...
  67. ncbi request reprint Virological features of hepatitis B virus-associated nephropathy in Japan
    Atsunori Kusakabe
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 79:1305-11. 2007
    ..Only one patient had core deletions. It is concluded that HBV/A may be associated with membranous nephropathy, but little relationship between HBV gene mutations and the development of HBV-associated nephropathy was observed...
  68. doi request reprint A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan
    Atsunori Kusakabe
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol 46:117-24. 2011
    ....
  69. ncbi request reprint Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populations
    Tomoyuki Sakamoto
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Infect Dis 196:1487-92. 2007
    ..The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types...
  70. ncbi request reprint Human immunodeficiency virus in Uzbekistan: epidemiological and genetic analyses
    Fuat Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    AIDS Res Hum Retroviruses 19:731-8. 2003
    ..However, the current study demonstrates a substantially increasing number of new infections, in association with IVDU, and an exponentially growing effective population size of the IVDU-associated HIV strain...
  71. ncbi request reprint Predicting relapse after cessation of Lamivudine monotherapy for chronic hepatitis B virus infection
    Kiyoaki Ito
    Department of Gastroenterology, Chukyo Hospital, Nagoya, Japan
    Clin Infect Dis 38:490-5. 2004
    ..27-0.9). More-prolonged lamivudine therapy is required after seroconversion, and persistent duration of an HBV DNA level of <0.7 log IU/mL for >6 months can more accurately aid in the decision of when to stop lamivudine therapy...
  72. ncbi request reprint Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma
    Tomoyoshi Ohno
    Department of Gastroenterology, Social Insurance Chukyo Hospital, Nagoya, Japan
    Hepatol Res 37:276-85. 2007
    ..Conclusions: In HCV-positive HCC patients, CTL inductivity by dendritic cells is impaired. This may be related to the impaired production of IFN-gamma...
  73. doi request reprint Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia
    Anis Khan
    Department of Clinical Molecular Informative Medicine, Nagoya City University, Mizuho, Nagoya 467 8601, Japan
    Virus Res 132:174-80. 2008
    ..This report provides evidence of an inter-communities transmission of HBV revealed by its genotypes. Further study is required to investigate peculiarities of the genotypes in different ethnic groups in Bolivia...
  74. ncbi request reprint [Nucleic acid-based testing for hepatitis B viruss infectious disease]
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 63:331-7. 2005
  75. ncbi request reprint Hepatitis C virus molecular epidemiology in Uzbekistan
    Fuat Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 69:367-75. 2003
    ....
  76. ncbi request reprint Molecular evolutionary analysis predicts the incidence of hepatocellular carcinoma in the United States and Japan
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Cancer Chemother Pharmacol 54:S83-6. 2004
    ..If HCC is a function of increased HCV exposure time, the molecular clock predicts that the burden of HCC in the US will accelerate in the next two to three decades...
  77. doi request reprint Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma
    Shigeru Kusumoto
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Int J Hematol 90:13-23. 2009
    ..In this review, we summarize the characteristics of HBV reactivation after systemic chemotherapy including rituximab, and propose a management strategy for malignant lymphoma patients suffering from HBV reactivation...
  78. ncbi request reprint Genotypes and phylogenetic characterization of hepatitis B and delta viruses in Egypt
    Niveen Saudy
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 70:529-36. 2003
    ..These results indicate that HBV genotype D and HDV genotype I are most prevalent in Egypt, and HDV co-infection in HBV carriers is related to severity of liver disease...
  79. ncbi request reprint [Clinical manifestations of hepatitis B virus genotypes]
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 62:293-8. 2004
  80. ncbi request reprint [HBV--clinical impact of HBV genotypes]
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 61:621-6. 2003
  81. ncbi request reprint Analysis of HCV genotypes from blood donors shows three new HCV type 6 subgroups exist in Myanmar
    Toshiyuki Shinji
    Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 58:135-42. 2004
    ..M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed...
  82. ncbi request reprint Interleukin 1beta gene polymorphism and hepatitis C virus-related hepatocellular carcinoma
    Anthony E T Yeo
    Hepatology 38:267-8; author reply 268-9. 2003
  83. ncbi request reprint Tracing the history of hepatitis B virus genotype D in western Japan
    Kojiro Michitaka
    Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    J Med Virol 78:44-52. 2006
    ..From the history of the area and the genetic analysis, HBV/D in this area was speculated to be of Russian origin...
  84. pmc Molecular evolution of hepatitis B virus over 25 years
    Carla Osiowy
    Public Health Agency of Canada, National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba R3E 3P6, Canada
    J Virol 80:10307-14. 2006
    ..The results of this study suggest that HBV sequence divergence may occur more rapidly than previously estimated, in a host immune phase-dependent manner...
  85. ncbi request reprint A reduction in selective immune pressure during the course of chronic hepatitis C correlates with diminished biochemical evidence of hepatic inflammation
    Kousuke Hanada
    National Institute of Genetics, Yata 1111, Mishima, Shizuoka, Japan
    Virology 361:27-33. 2007
    ..This observation may be applicable to other viruses characterized by a slow rate of disease progression...
  86. ncbi request reprint Variations in the core promoter/pre-core region in HBV genotype C in Japanese and Northern Vietnamese patients
    Bui Xuan Truong
    Kobe University Graduate School of Medicine, Clinical Molecular Medicine, Kobe, Japan
    J Med Virol 79:1293-304. 2007
    ..The subgenotypes and unique mutations of HBV genotype C in the Vietnamese and Japanese differed, and C/A1753 and C1858 variants might play a role in the pathogenesis of liver disease in Vietnamese patients...
  87. ncbi request reprint Reliability of hepatitis C virus core antigen assay for detection of viremia in HCV genotypes 1, 2, 3, and 4 infected blood donors: a collaborative study between Japan, Egypt, and Uzbekistan
    Salah Agha
    Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    J Med Virol 73:216-22. 2004
    ..No specific mutation was found in the core-encoding region of the studied specimens. In conclusion, HCVcAg is shown to be specific, sensitive, and informative qualitative index for HCV viremia in asymptomatic carriers...
  88. ncbi request reprint Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Carcinogenesis 25:1593-8. 2004
    ..The association between HBV genotype C and HCC was probably not genuine but was due to the high percentage of CP mutations in patients with genotype C...
  89. ncbi request reprint Hepatitis B virus (HBV) genotypes/subgenotypes in China: mutations in core promoter and precore/core and their clinical implications
    Jing Yuan
    Shenzhen East Lake Hospital, Shenzhen, China
    J Clin Virol 39:87-93. 2007
    ..The association of hepatitis B virus (HBV) genotypes with clinical course of infection is increasingly recognized...
  90. doi request reprint What can be revealed by extending the sensitivity of HBsAg detection to below the present limit?
    Hitoshi Togashi
    Department of Gastroenterology, Course of Internal Medicine and Therapeutics, Yamagata University Faculty of Medicine, Yamagata University Health Administration Center, 1 4 12 Kojirakawa machi, Yamagata 990 8560, Japan
    J Hepatol 49:17-24. 2008
    ..We investigated what can be revealed by extending the sensitivity of HBsAg detection to below the present limit...
  91. pmc When should "I" consider a new hepatitis B virus genotype?
    Fuat Kurbanov
    J Virol 82:8241-2. 2008
  92. ncbi request reprint Hepatitis B virus transmission pattern and vaccination efficiency in Uzbekistan
    Dildora Avazova
    National Reference Laboratory, Ministry of Public Health, Tashkent, Uzbekistan
    J Med Virol 80:217-24. 2008
    ..In conclusion, HBV universal vaccination is efficient in Uzbekistan irrespective of the vaccine formulation used, because the horizontal transmission pattern predominates currently in this endemic region...
  93. ncbi request reprint Comparison of genotypes C and D of the hepatitis B virus in Japan: a clinical and molecular biological study
    Tran Nhu Duong
    Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    J Med Virol 72:551-7. 2004
    ..Thus, the outcome of chronic HBV infection may be different in persons infected with HBV genotypes C and D...
  94. ncbi request reprint [Epidemiology of intrafamilial transmission of hepatitis C virus by molecular evolutionary analysis]
    Izumi Hasegawa
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 62:291-5. 2004
  95. pmc Clinical and virological characteristics of hepatitis B virus subgenotypes Ba, C1, and C2 in China
    Zhanhui Wang
    Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    J Clin Microbiol 45:1491-6. 2007
    ..Therefore, genotyping and detecting the 1653T and 1753V mutations, in addition to the A1762T G1764A double mutation, might have important clinical implications as predictive risk factors for hepatocarcinogenesis...
  96. ncbi request reprint Molecular epidemiological study of hepatitis B virus infection in two different ethnic populations from the Solomon Islands
    Takako Utsumi
    Department of International and Environmental Medical Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
    J Med Virol 79:229-35. 2007
    ..HBeAg appears to clear from the serum in young adulthood in HBV/D infection, which may be influenced by genotype-dependent features in relation to viral mutations...
  97. ncbi request reprint High frequency of hepatocellular carcinoma in Mongolia; association with mono-, or co-infection with hepatitis C, B, and delta viruses
    Tsendsuren Oyunsuren
    Laboratory of Molecular Biology, The Institute of Biology, Mongolian Academy of Sciences, Ulaanbaatar, Mongolia
    J Med Virol 78:1688-95. 2006
    ..Liver tumor markers; AFP and PIVKA-II are useful tools for complex HCC-screening and clinical follow-up for chronic hepatitis patients in Mongolia...
  98. ncbi request reprint Molecular tracing of Japan-indigenous hepatitis E viruses
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Gen Virol 87:949-54. 2006
    ..In conclusion, these data suggest that the indigenization and spread of HEV in Japan were associated with the popularization of eating pork...
  99. ncbi request reprint Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    J Hepatol 41:119-25. 2004
    ..We conducted a population study to document the prevalence of hepatitis B virus (HBV) genotypes in Hong Kong...