Yoshifumi Takei

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. doi request reprint In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mol Cancer Ther 7:211-21. 2008
  2. ncbi request reprint A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Cancer Res 64:3365-70. 2004
  3. ncbi request reprint Morpholino antisense oligomer targeting human midkine: its application for cancer therapy
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 114:490-7. 2005
  4. doi request reprint The metastasis-associated microRNA miR-516a-3p is a novel therapeutic target for inhibiting peritoneal dissemination of human scirrhous gastric cancer
    Yoshifumi Takei
    Department of Biochemistry and Division of Disease Models, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 71:1442-53. 2011
  5. ncbi request reprint Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer 107:864-73. 2006
  6. doi request reprint Systemic delivery of siRNA specific to tumor mediated by atelocollagen: combined therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer
    Ping Mu
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 125:2978-90. 2009
  7. doi request reprint Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction
    Yasuhiro Suzuki
    Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 81:865-79. 2012
  8. pmc Atelocollagen-mediated systemic delivery prevents immunostimulatory adverse effects of siRNA in mammals
    Shinichiro Inaba
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Ther 20:356-66. 2012
  9. ncbi request reprint Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts
    Hiroshi Banno
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Vasc Surg 44:633-41. 2006
  10. pmc Growth factor midkine is involved in the pathogenesis of diabetic nephropathy
    Tomoki Kosugi
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Pathol 168:9-19. 2006

Collaborators

Detail Information

Publications24

  1. doi request reprint In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mol Cancer Ther 7:211-21. 2008
    ..Our data will provide the technical basis for in vivo electroporation, and this simple and efficient siRNA delivery method is applicable to in vivo comprehensive screening for a molecular target...
  2. ncbi request reprint A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Cancer Res 64:3365-70. 2004
    ..c. xenograft model. Atelocollagen provided a beneficial delivering means by which stabilization and efficient transfection of the siRNA injected into the tumors were achieved...
  3. ncbi request reprint Morpholino antisense oligomer targeting human midkine: its application for cancer therapy
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 114:490-7. 2005
    ..Serological examinations demonstrated no toxicity of MK morpholino antisense oligomers. Our study indicates that inhibition of MK expression by morpholino antisense oligomer is a promising novel and safe therapeutic strategy for cancers...
  4. doi request reprint The metastasis-associated microRNA miR-516a-3p is a novel therapeutic target for inhibiting peritoneal dissemination of human scirrhous gastric cancer
    Yoshifumi Takei
    Department of Biochemistry and Division of Disease Models, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 71:1442-53. 2011
    ..Our findings define the miRNA miR-516-3p as an antimetastamir with potential therapeutic applications in blocking metastatic dissemination of gastric cancers...
  5. ncbi request reprint Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer 107:864-73. 2006
    ..Midkine (MK) is a heparin-binding growth factor that promotes the growth, migration, and survival of various cells. Its overexpression has been observed in many human malignancies, making it an attractive therapeutic target...
  6. doi request reprint Systemic delivery of siRNA specific to tumor mediated by atelocollagen: combined therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer
    Ping Mu
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 125:2978-90. 2009
    ..Our results indicate that systemic delivery of siRNA via atelocollagen, which specifically targets tumors, is safe and feasible for cancer therapy...
  7. doi request reprint Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction
    Yasuhiro Suzuki
    Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 81:865-79. 2012
    ..Thus, TGF-β1 induces VEGF-C expression, which leads to lymphangiogenesis...
  8. pmc Atelocollagen-mediated systemic delivery prevents immunostimulatory adverse effects of siRNA in mammals
    Shinichiro Inaba
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Ther 20:356-66. 2012
    ..For the goal of realizing siRNA-based medicines for humans, atelocollagen is an excellent and promising delivery vehicle, and it has the useful advantage of evading detection by the "radar" of innate immunity...
  9. ncbi request reprint Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts
    Hiroshi Banno
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Vasc Surg 44:633-41. 2006
    ..In this study, we evaluated a strategy of using small interfering RNA (siRNA) targeting MK as a therapy for vein graft failure...
  10. pmc Growth factor midkine is involved in the pathogenesis of diabetic nephropathy
    Tomoki Kosugi
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Pathol 168:9-19. 2006
    ..Therefore, this study identifies midkine as a key molecule in diabetic nephropathy and suggests that midkine accelerates the intracellular signaling network evoked by hyperglycemia in nephropathy...
  11. ncbi request reprint Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion
    Waichi Sato
    Department of Clinical Immunology of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 67:1330-9. 2005
    ..In the present investigation, we planned to evaluate the usefulness of antisense midkine for the therapy of ischemic renal failure...
  12. ncbi request reprint Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates hapten-induced contact hypersensitivity
    Takuji Ishimoto
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Ther 16:387-95. 2008
    ..This therapy had no adverse effects such as induction of interferon, or liver or renal damage. Our data indicate that the systemic delivery of siRNA targeting MCP-1 is a potent therapeutic strategy for CHS treatment...
  13. pmc Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1
    Kazuma Sakamoto
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    J Biol Chem 286:8405-13. 2011
    ..Our results suggest that the premature ligand-receptor interaction plays a role in protein production within the secretory pathway...
  14. pmc Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage
    Hanayo Kawai
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Pathol 165:1603-12. 2004
    ..The results indicate the crucial role of inflammation in cisplatin-induced renal damage, and provide a candidate molecular target for its prevention...
  15. ncbi request reprint Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells
    Sen Chen
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 120:4009-15. 2007
    ..Collectively, these data demonstrate a crucial role of MK-LRP1 signaling in anchorage-independent cell growth...
  16. ncbi request reprint Establishment and optimal culture conditions of microrna-induced pluripotent stem cells generated from HEK293 cells via transfection of microrna-302s expression vector
    Naoshi Koide
    Department of Biochemistry, Center for Neurological Diseases and Cancer Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nagoya J Med Sci 74:157-65. 2012
    ....
  17. doi request reprint Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients
    Akiho Sawai
    Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nephrol Dial Transplant 26:2322-32. 2011
    ..The aim of this study was to investigate the relationship between peritoneal local inflammation, angiogenesis and systemic inflammation and baseline peritoneal permeability...
  18. ncbi request reprint Antisense oligodeoxyribonucleotide as to the growth factor midkine suppresses neointima formation induced by balloon injury
    Kenji Hayashi
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Physiol Heart Circ Physiol 288:H2203-9. 2005
    ..The antisense ODN suppressed MK induction in vivo and consequently suppressed neointima formation to 60% of the control level. These results suggest that MK is a candidate molecular target for the therapy for vascular restenosis...
  19. ncbi request reprint Midkine expression is associated with postnatal development of the lungs
    Onrai Matsuura
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Cell Struct Funct 27:109-15. 2002
    ..Furthermore, a pronounced induction of midkine by retinoic acid was observed in neonatal lungs. The results indicate that midkine expression is associated with postnatal lung development, but not necessarily with hyperoxic cell damage...
  20. ncbi request reprint 5'-,3'-inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine. Its design and application for cancer therapy
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 277:23800-6. 2002
    ..These findings indicated the usefulness of inverted thymidine-modified antisense oligodeoxynucleotides as a new reagent instead of phosphorothioate-modified oligodeoxynucleotides...
  21. doi request reprint Lymphatic vessels develop during tubulointerstitial fibrosis
    Izumi Sakamoto
    Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Japan
    Kidney Int 75:828-38. 2009
    ..Lymphangiogenesis and VEGF-C expression was elevated in diabetic nephropathy in comparison to other renal diseases. Our results indicate that lymphangiogenesis is a common feature in the progression of the tubulointerstitial fibrosis...
  22. doi request reprint Overexpression of BMI-1 correlates with drug resistance in B-cell lymphoma cells through the stabilization of survivin expression
    Joyeeta Bhattacharyya
    Department of Hematology and Oncology, Hiroshima University, Hiroshima, Japan
    Cancer Sci 103:34-41. 2012
    ..BMI-1 could be an important prognostic marker as well as a future therapeutic target in the treatment of drug-resistant lymphomas...
  23. ncbi request reprint Midkine, a heparin-binding growth factor, promotes growth and glycosaminoglycan synthesis of endothelial cells through its action on smooth muscle cells in an artificial blood vessel model
    Yukio Sumi
    Department of Oral and Maxillofacial Surgery, Nagoya Daini Red Cross Hospital, 2 9 Myoken cho, Showa Ku, Nagoya 466 8650, Japan
    J Cell Sci 115:2659-67. 2002
    ..Furthermore, interleukin-8 caused stratification of the endothelial cells in the blood vessel model. These results provided evidence that midkine is one of the factors involved in epithelial-mesenchymal interactions...
  24. ncbi request reprint Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer
    Takuma Fujii
    Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Int J Oncol 29:541-8. 2006
    ..These results indicate that atelocollagen-mediated delivery of siRNA HPV18 E6 and E7 can be used as a novel therapeutic approach for cervical cancer...