H Takano

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint Junctional transmissions in smooth muscle of the guinea pig duodenum and their modulation by the prokinetic agent DQ-2511
    H Takano
    Department of Physiology, Nagoya City University Medical School, Nagoya
    Pharmacology 58:236-45. 1999
  2. ncbi request reprint Mechanical responses evoked by nerve stimulation in gastric muscles of mouse lacking inositol trisphosphate receptor
    H Takano
    Department of Physiology, Nagoya City University Medical School, Japan
    Auton Neurosci 87:249-57. 2001
  3. ncbi request reprint Electrical properties of colonic smooth muscle in spontaneously non-insulin-dependent diabetic rats
    K Imaeda
    Department of Physiology, Nagoya City University Medical School, Japan
    J Smooth Muscle Res 34:1-11. 1998
  4. pmc Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor
    H Suzuki
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    J Physiol 525:105-11. 2000
  5. ncbi request reprint Properties of spontaneous electrical activity in smooth muscle of the guinea-pig renal pelvis
    H Takano
    Department of Physiology, Nagoya City University Medical School, Nagoya, 467 8601 Japan
    Jpn J Physiol 50:597-603. 2000
  6. pmc Origin and propagation of spontaneous excitation in smooth muscle of the guinea-pig urinary bladder
    H Hashitani
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    J Physiol 530:273-86. 2001
  7. ncbi request reprint Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
    M Matsumoto
    Department of Molecular Neurobiology, University of Tokyo, Japan
    Nature 379:168-71. 1996
  8. ncbi request reprint Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand
    Y Morishima
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:7551-60. 2001
  9. ncbi request reprint Characterization of the spontaneous electrical and contractile activity of smooth muscle cells in the rat upper urinary tract
    R J Lang
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Urol 166:329-34. 2001
  10. pmc Modulators of internal Ca2+ stores and the spontaneous electrical and contractile activity of the guinea-pig renal pelvis
    R J Lang
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    Br J Pharmacol 135:1363-74. 2002

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Junctional transmissions in smooth muscle of the guinea pig duodenum and their modulation by the prokinetic agent DQ-2511
    H Takano
    Department of Physiology, Nagoya City University Medical School, Nagoya
    Pharmacology 58:236-45. 1999
    ..The results suggest that the prokinetic actions of DQ-2511 involve an enhancement of transmission from substance P neurons due to an increase in sensitivity of postjunctional receptors to substance P...
  2. ncbi request reprint Mechanical responses evoked by nerve stimulation in gastric muscles of mouse lacking inositol trisphosphate receptor
    H Takano
    Department of Physiology, Nagoya City University Medical School, Japan
    Auton Neurosci 87:249-57. 2001
    ..In addition, the mutation induces a substance P projection which is not detected in wild mice...
  3. ncbi request reprint Electrical properties of colonic smooth muscle in spontaneously non-insulin-dependent diabetic rats
    K Imaeda
    Department of Physiology, Nagoya City University Medical School, Japan
    J Smooth Muscle Res 34:1-11. 1998
    ..These results suggest that the constipation appearing with diabetes mellitus involves dysfunction of both the enteric autonomic nerves and the smooth muscles in the colon...
  4. pmc Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor
    H Suzuki
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    J Physiol 525:105-11. 2000
    ..A lack of InsP3 receptors attenuates cholinergic excitatory and nitrergic inhibitory responses but does not alter the response to noradrenaline...
  5. ncbi request reprint Properties of spontaneous electrical activity in smooth muscle of the guinea-pig renal pelvis
    H Takano
    Department of Physiology, Nagoya City University Medical School, Nagoya, 467 8601 Japan
    Jpn J Physiol 50:597-603. 2000
    ..Endogenous prostaglandins may be involved in the initiation of spontaneous activity...
  6. pmc Origin and propagation of spontaneous excitation in smooth muscle of the guinea-pig urinary bladder
    H Hashitani
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    J Physiol 530:273-86. 2001
    ....
  7. ncbi request reprint Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
    M Matsumoto
    Department of Molecular Neurobiology, University of Tokyo, Japan
    Nature 379:168-71. 1996
    ....
  8. ncbi request reprint Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand
    Y Morishima
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:7551-60. 2001
    ..These findings raise the possibility that the JNK pathway may also contribute to Abeta-dependent death in AD patients...
  9. ncbi request reprint Characterization of the spontaneous electrical and contractile activity of smooth muscle cells in the rat upper urinary tract
    R J Lang
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Urol 166:329-34. 2001
    ....
  10. pmc Modulators of internal Ca2+ stores and the spontaneous electrical and contractile activity of the guinea-pig renal pelvis
    R J Lang
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    Br J Pharmacol 135:1363-74. 2002
    ..The inhibitory actions of modulators of internal Ca(2+) release were partially explained by a blockade of Ca(2+) entry...
  11. ncbi request reprint A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms
    H Takano
    Division of Cardiology, University of Louisville and Jewish Heart and Lung Institute, Louisville, KY, USA
    Circ Res 88:520-8. 2001
    ..However, A(1)AR-induced late PC uses an NOS-dependent pathway whereas A(3)AR-induced late PC is mediated by an NOS-independent pathway...
  12. ncbi request reprint Change of muscle motor-evoked potentials after motor cortex stimulation caused by acute spinal cord injury in cats
    S Nakatoh
    Department of Orthopaedic Surgery, Asahi General Hospital, Toyama, Japan
    J Spinal Disord 14:32-8. 2001
    ..No motor dysfunction was present 3 weeks after the experiment. ECMAP is clinically useful, providing information on impairments of the spinal cord that otherwise would remain undetected...
  13. pmc Complex phenotype of mice lacking occludin, a component of tight junction strands
    M Saitou
    Department of Cell Biology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Mol Biol Cell 11:4131-42. 2000
    ..These phenotypes suggested that the functions of TJs as well as occludin are more complex than previously supposed...
  14. ncbi request reprint Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene
    H Takeshima
    International Institute for Advanced Studies, Kyoto, Japan
    Nature 369:556-9. 1994
    ....
  15. ncbi request reprint Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice
    H Takano
    Regional Environment Division, National Institute for Environmental Studies, Tsukuba, Japan
    Lab Invest 80:371-7. 2000
    ..These results provide direct evidence that intrinsic MT plays a cytoprotective role in gastroduodenal mucosal injury caused by ethanol...
  16. pmc Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand
    K Murata
    Department of Microbiology and Immunology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Exp Med 191:365-74. 2000
    ..Collectively, these results provide convincing evidence that OX40L, expressed on APCs, plays a critical role in antigen-specific T cell responses in vivo...
  17. ncbi request reprint Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout
    Y Doi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 274:2315-21. 1999
    ..These findings favor the notion that ERM proteins are functionally redundant at the cellular as well as the whole body level...
  18. ncbi request reprint Diesel exhaust particles enhance airway responsiveness following allergen exposure in mice
    H Takano
    Research Team for Health Effects of Air Pollutants, National Institute for Environmental Studies, Ibaraki, Japan
    Immunopharmacol Immunotoxicol 20:329-36. 1998
    ....
  19. pmc Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
    H Kawate
    Department of Biochemistry, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 95:5116-20. 1998
    ..Thus, killing and tumorigenic effects of an alkylating agent can be dissociated by preventing mismatch repair pathways...
  20. pmc Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor
    M Niki
    Department of Molecular Immunology, Institute of Development, Aging, and Cancer, Tohoku University, Seiryo machi, Aoba ku, Sendai 980, Japan
    Proc Natl Acad Sci U S A 94:5697-702. 1997
    ..Thus, the results indicate that the two subunits function together as a heterodimeric PEBP2/CBF in vivo and that PEBP2/CBF plays an essential role in the development of definitive hematopoiesis...
  21. pmc G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo
    A Nagata
    Department of Medicine, Kobe University School of Medicine, Japan
    Proc Natl Acad Sci U S A 93:11825-30. 1996
    ..These results clearly demonstrated that the G protein-coupled CCK-B/gastrin receptor is essential for the physiological as well as pathological proliferation of gastric mucosal cells in vivo...
  22. pmc Japanese cases of familial hemiplegic migraine with cerebellar ataxia carrying a T666M mutation in the CACNA1A gene
    T Takahashi
    J Neurol Neurosurg Psychiatry 72:676-7. 2002