Kazumitsu Sugiura

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. doi request reprint Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Dermatol Sci 69:181-6. 2013
  2. doi request reprint The unfolded protein response is activated in differentiating epidermal keratinocytes
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Invest Dermatol 129:2126-35. 2009
  3. ncbi request reprint Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Nagoya J Med Sci 70:97-106. 2008
  4. ncbi request reprint LEDGF/DFS70, a major autoantigen of atopic dermatitis, is a component of keratohyalin granules
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    J Invest Dermatol 127:75-80. 2007
  5. doi request reprint Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition
    Takuya Takeichi
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Invest Dermatol 130:2760-7. 2010
  6. ncbi request reprint Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients
    Miyako Okamoto
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Autoimmun 23:257-66. 2004
  7. ncbi request reprint Anti-p80 coilin autoantibodies react with a conserved epitope and are associated with anti-DFS70/LEDGF autoantibodies
    Naoya Goto
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Autoimmun 26:42-51. 2006
  8. doi request reprint Low prevalence of autoantibodies to CENP-H, -I, -K, -L, -M, -N, -T and -U in a Japanese cohort of anti-centromere positive samples
    Akiko Saito
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Immunopharmacol Immunotoxicol 35:57-63. 2013
  9. doi request reprint Clinical features of anti-TIF1-α antibody-positive dermatomyositis patients are closely associated with coexistent dermatomyositis-specific autoantibodies and anti-TIF1-γ or anti-Mi-2 autoantibodies
    Yoshinao Muro
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Rheumatology (Oxford) 51:1508-13. 2012
  10. doi request reprint IgE and IgG(4) autoantibodies against DFS70/LEDGF in atopic dermatitis
    Kanako Watanabe
    Division of Connective Tissue and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Autoimmunity 44:511-9. 2011

Collaborators

Detail Information

Publications29

  1. doi request reprint Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Dermatol Sci 69:181-6. 2013
    ..This review describes the UPR in normal and abnormal keratinization and discusses the regulation of abnormal UPR activation by chemical chaperones as a potential treatment for one of the hereditary keratoses...
  2. doi request reprint The unfolded protein response is activated in differentiating epidermal keratinocytes
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Invest Dermatol 129:2126-35. 2009
    ..Taken together, our findings strongly suggest that the UPR is activated during normal epidermal KC differentiation and induces C/EBPbeta, KLF4, and ABCA12 mRNAs...
  3. ncbi request reprint Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Nagoya J Med Sci 70:97-106. 2008
    ..For patients in whom cetirizine fails to satisfactorily alleviate symptoms as well as those who complain of drowsiness, switching to other antihistamine drugs may be an effective strategy...
  4. ncbi request reprint LEDGF/DFS70, a major autoantigen of atopic dermatitis, is a component of keratohyalin granules
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    J Invest Dermatol 127:75-80. 2007
    ..Once in the cytoplasm, LEDGF/DFS70 accumulates in the KGs in the granular layer. Finally, LEDGF/DFS70, a "nuclear" autoantigen in AD, may play a functional role in the KGs...
  5. doi request reprint Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition
    Takuya Takeichi
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Invest Dermatol 130:2760-7. 2010
    ..These findings are compatible with the expression pattern in psoriatic tissues. Taken together, these results strongly suggest that ectopic expression of LEDGF/DFS70 in KCs could be involved in the pathology of psoriasis vulgaris...
  6. ncbi request reprint Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients
    Miyako Okamoto
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Autoimmun 23:257-66. 2004
    ..The elevated anti-DFS70 antibodies in alopecia patients and the localization of the DFS70 in the ORS suggest that autoantibodies against the DFS70 are related to the etiology in a certain population of AA...
  7. ncbi request reprint Anti-p80 coilin autoantibodies react with a conserved epitope and are associated with anti-DFS70/LEDGF autoantibodies
    Naoya Goto
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Autoimmun 26:42-51. 2006
    ..We conclude that the presence of anti-p80 coilin autoantibodies is not associated with any particular clinical syndromes nor is it diagnostic of any conditions...
  8. doi request reprint Low prevalence of autoantibodies to CENP-H, -I, -K, -L, -M, -N, -T and -U in a Japanese cohort of anti-centromere positive samples
    Akiko Saito
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Immunopharmacol Immunotoxicol 35:57-63. 2013
    ..CENP-H, -I, -K, -L, -M, -N, -T, and -U have been reported as the constitutive components of ICEN. In this study, we examined the reactivities of ACA to the 8 CENPs for the purpose of investigating their autoantigenicity...
  9. doi request reprint Clinical features of anti-TIF1-α antibody-positive dermatomyositis patients are closely associated with coexistent dermatomyositis-specific autoantibodies and anti-TIF1-γ or anti-Mi-2 autoantibodies
    Yoshinao Muro
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Rheumatology (Oxford) 51:1508-13. 2012
    ..This study aimed to identify a subset of DM patients who have anti-TIF1-α antibodies by using biotinylated recombinant proteins and to clarify the clinical and other serological features of DM patients with these antibodies...
  10. doi request reprint IgE and IgG(4) autoantibodies against DFS70/LEDGF in atopic dermatitis
    Kanako Watanabe
    Division of Connective Tissue and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Autoimmunity 44:511-9. 2011
    ..Although DFS70 is considered to be one of these proteins, to date, there has not been a detailed analysis of the significance of this putative autoantigen...
  11. doi request reprint Anti-MDA5 and anti-TIF1-gamma antibodies have clinical significance for patients with dermatomyositis
    Kei Hoshino
    Department of Dermatology, Division of Connective Tissue Disease and Autoimmunity, Nagoya University Graduate School of Medicine, 65 Turumai cho, Showa Ku, Nagoya 466 8550, Japan
    Rheumatology (Oxford) 49:1726-33. 2010
    ..Here, we detected these autoantibodies in patient sera using new assays with recombinant MDA5 and TIF1-gamma, and associated clinical features with the presence of anti-MDA5 or anti-TIF1-gamma antibodies...
  12. ncbi request reprint Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain
    Yasushi Ogawa
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    J Autoimmun 23:221-31. 2004
    ..We propose that anti-DFS70 antibody may be a natural autoantibody, which might modify or reflect the inflammatory process of various disorders...
  13. ncbi request reprint HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease
    Yoshinao Muro
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Showa Ku, Japan
    J Autoimmun 26:252-7. 2006
    ..HLA class II genes influence the production of anti-DFS70 antibodies among individuals with various clinical manifestations...
  14. doi request reprint Limitations of a single-point evaluation of anti-MDA5 antibody, ferritin, and IL-18 in predicting the prognosis of interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis
    Yoshinao Muro
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Rheumatol 32:395-8. 2013
    ..We consider that the timing of initial therapy and the anti-MDA5ab isotype, in addition to the patient's age, are also crucial factors for predicting the prognosis...
  15. doi request reprint Anti-SS-A/Ro antibody determination by indirect immunofluorescence and comparison of different methods of anti-nuclear antibody screening: evaluation of the utility of HEp-2 cells transfected with the 60 kDa SS-A/Ro as a substrate
    Noriyo Tanaka
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Mod Rheumatol 18:585-92. 2008
    ....
  16. doi request reprint Disappearance of anti-MDA-5 autoantibodies in clinically amyopathic DM/interstitial lung disease during disease remission
    Yoshinao Muro
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Rheumatology (Oxford) 51:800-4. 2012
    ..This study aimed to establish a quantitative assay for anti-MDA-5 antibodies towards assessing the long-term outcome of ADM patients who had anti-MDA-5 antibodies...
  17. doi request reprint Development of an ELISA for detection of autoantibodies to nuclear matrix protein 2
    Asuka Ishikawa
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Rheumatology (Oxford) 51:1181-7. 2012
    ..This study aimed to identify a subset of DM patients who have anti-nuclear matrix protein 2 (anti-NXP-2) antibodies by using biotinylated recombinant proteins, and to clarify the clinical features of DM patients with these antibodies...
  18. doi request reprint CENP-O, a protein localized at the centromere throughout the cell cycle, is a novel target antigen in systemic sclerosis
    Akiko Saito
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Turumai cho Showa ku, Nagoya, 466 8550, Japan
    J Rheumatol 36:781-6. 2009
    ..The CENP-O protein is a component of the ICEN that localizes at the centromere throughout the cell cycle. We investigated whether CENP-O is also targeted by sera from patients with systemic autoimmune diseases...
  19. doi request reprint Cyclosporin A induces the unfolded protein response in keratinocytes
    Michiko Hibino
    Department of Dermatology, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Japan
    Arch Dermatol Res 303:481-9. 2011
    ..CyA treatment and siRNA-mediated knockdown of Cyp B induced the UPR in HaCaT cells or HSC-1 cells. Altogether, we demonstrate that in psoriasis vulgaris CyA or reduction in Cyp B by RNA interference might induce the UPR in keratinocytes...
  20. doi request reprint Epidermal growth factor receptor tyrosine kinase inhibitors induce CCL2 and CCL5 via reduction in IL-1R2 in keratinocytes
    Mayuko Yamaki
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Exp Dermatol 19:730-5. 2010
    ..Taken together, our data strongly suggest that IL-1-mediated signalling is activated to induce the high expression of CCL2 and CCL5 via reduction in IL-1R2 in the skin lesions caused by gefitinib...
  21. doi request reprint Low prevalence of anti-small ubiquitin-like modifier activating enzyme antibodies in dermatomyositis patients
    Yoshinao Muro
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Autoimmunity 46:279-84. 2013
    ..Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in European Caucasians...
  22. pmc Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan
    Yoshinao Muro
    Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Arthritis Res Ther 13:R214. 2011
    ..The present study aims to assess the growing prevalence of CADM and the geographical incidence of anti-MDA-5-positive patients...
  23. ncbi request reprint Anti-DFS70 antibodies in 597 healthy hospital workers
    Akihiro Watanabe
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Arthritis Rheum 50:892-900. 2004
    ..We undertook this study to examine the frequency of anti-DFS70 antibodies in a large number of healthy people...
  24. doi request reprint Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease
    Michihiro Kono
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hum Mol Genet 22:3524-33. 2013
    ..These results reveal that mutations in ADAM10 are a cause of RAK and that RAK is an independent clinical entity distinct from DDD. ..
  25. ncbi request reprint Extraordinarily long linear cutaneous lupus erythematosus along the lines of Blaschko
    Akiteru Aiyama
    Department of Dermatology, Nagoya Graduate University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Dermatol Online J 19:18960. 2013
    ..Although the most common site for LCLE is the face, a few cases of LCLE on the extremities have been reported. To our knowledge, this is the first reported case of an extraordinarily long, continuous LCLE skin lesion. ..
  26. doi request reprint Possible roles of barrier-to-autointegration factor 1 in regulation of keratinocyte differentiation and proliferation
    Hiroyuki Takama
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Dermatol Sci 71:100-6. 2013
    ..Recent studies have clarified that BANF1 is a causative molecule of Nestor-Guillermo progeria syndrome. Despite recent progress in studies on BANF1, the role of BANF1 in keratinocytes has not been addressed at all...
  27. doi request reprint The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist
    Kazumitsu Sugiura
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Invest Dermatol 133:2514-21. 2013
    ..We determined that GPP alone is a distinct subtype of GPP and is etiologically distinguished from GPP with PV, and that the majority of GPP alone is caused by deficiency of the interleukin-36 receptor antagonist due to IL36RN mutations. ..
  28. pmc Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers
    Hiroyuki Kamei
    Department of Clinical Pharmacy Practice and Health Care Management, Meijo University, Nagoya, Japan
    Arch Dermatol Res 304:263-72. 2012
    ..These results suggest that olopatadine at a therapeutic dose has greater antihistaminergic activity than promethazine, and olopatadine and fexofenadine did not cause cognitive or psychomotor impairment...
  29. doi request reprint Successful topical hemotherapy with a new occlusive dressing for an intractable ulcer on the toe
    Michiko Iwayama-Hibino
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Dermatol 36:245-8. 2009
    ..As conventional topical hemotherapy cannot be applied to ulcers on the round tip of a toe, we made a device for occlusive dressing of topical hemotherapy which could successfully improve the previously refractory ulcer...