Yoshiharu Shimomura

Summary

Affiliation: Nagoya Institute of Technology
Country: Japan

Publications

  1. ncbi request reprint Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms
    Rumi Kobayashi
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Arch Biochem Biophys 407:231-40. 2002
  2. ncbi request reprint Nutraceutical effects of branched-chain amino acids on skeletal muscle
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan
    J Nutr 136:529S-532S. 2006
  3. ncbi request reprint Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima Fatty rat both before and after the onset of diabetes mellitus
    Gustavo Bajotto
    Department of Sports Medicine, Graduate School of Medicine, Nagoya University, 464 8601, Japan
    Life Sci 75:2117-30. 2004
  4. ncbi request reprint Branched-chain amino acid catabolism in exercise and liver disease
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya 466 8555, Japan
    J Nutr 136:250S-3S. 2006
  5. ncbi request reprint Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya 466 8555, Japan
    J Nutr 134:1583S-1587S. 2004
  6. ncbi request reprint Effects of liver failure on the enzymes in the branched-chain amino acid catabolic pathway
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan
    Biochem Biophys Res Commun 313:381-5. 2004
  7. ncbi request reprint Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology Graduate School of Engineering, Nagoya, Japan
    Biosci Biotechnol Biochem 69:1819-23. 2005
  8. ncbi request reprint Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness
    Yoshiharu Shimomura
    Dept of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Int J Sport Nutr Exerc Metab 20:236-44. 2010
  9. doi request reprint Clofibrate-induced reduction of plasma branched-chain amino acid concentrations impairs glucose tolerance in rats
    Yoshihiro Kadota
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    JPEN J Parenter Enteral Nutr 36:337-43. 2012
  10. ncbi request reprint Effects of branched-chain amino acid supplementation on plasma concentrations of free amino acids, insulin, and energy substrates in young men
    Yi Zhang
    Laboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    J Nutr Sci Vitaminol (Tokyo) 57:114-7. 2011

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms
    Rumi Kobayashi
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Arch Biochem Biophys 407:231-40. 2002
    ....
  2. ncbi request reprint Nutraceutical effects of branched-chain amino acids on skeletal muscle
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan
    J Nutr 136:529S-532S. 2006
    ..These findings suggest that BCAAs may be useful for muscle recovery following exercise...
  3. ncbi request reprint Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima Fatty rat both before and after the onset of diabetes mellitus
    Gustavo Bajotto
    Department of Sports Medicine, Graduate School of Medicine, Nagoya University, 464 8601, Japan
    Life Sci 75:2117-30. 2004
    ....
  4. ncbi request reprint Branched-chain amino acid catabolism in exercise and liver disease
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya 466 8555, Japan
    J Nutr 136:250S-3S. 2006
    ..The resulting activation of the BCKDH complex appears responsible for the increase in BCAA catabolism caused by exercise and liver cirrhosis. Our findings support the use of BCAA supplements for patients with liver cirrhosis...
  5. ncbi request reprint Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya 466 8555, Japan
    J Nutr 134:1583S-1587S. 2004
    ....
  6. ncbi request reprint Effects of liver failure on the enzymes in the branched-chain amino acid catabolic pathway
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan
    Biochem Biophys Res Commun 313:381-5. 2004
    ..The findings described here suggest that alterations in hepatic enzyme activities in the BCAA catabolism are associated with liver failure...
  7. ncbi request reprint Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology Graduate School of Engineering, Nagoya, Japan
    Biosci Biotechnol Biochem 69:1819-23. 2005
    ..These results suggest that, compared to regular chocolate, fat absorption in the gut was less after ingesting the non-sugar chocolate, presumably resulting in less effect on body fat deposition...
  8. ncbi request reprint Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness
    Yoshiharu Shimomura
    Dept of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Int J Sport Nutr Exerc Metab 20:236-44. 2010
    ..These results suggest that muscle damage may be suppressed by BCAA supplementation...
  9. doi request reprint Clofibrate-induced reduction of plasma branched-chain amino acid concentrations impairs glucose tolerance in rats
    Yoshihiro Kadota
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    JPEN J Parenter Enteral Nutr 36:337-43. 2012
    ..These results suggest that plasma BCAAs play an important role in maintaining normal glucose tolerance in rats...
  10. ncbi request reprint Effects of branched-chain amino acid supplementation on plasma concentrations of free amino acids, insulin, and energy substrates in young men
    Yi Zhang
    Laboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    J Nutr Sci Vitaminol (Tokyo) 57:114-7. 2011
    ..The ingestion of BCAAs temporarily increased plasma insulin levels and affected plasma concentrations of FFAs, but had almost no effect on glucose or urea nitrogen...
  11. doi request reprint Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles
    Gustavo Bajotto
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464 8601, Japan
    Eur J Appl Physiol 111:1815-28. 2011
    ....
  12. ncbi request reprint Determinants of disuse-induced skeletal muscle atrophy: exercise and nutrition countermeasures to prevent protein loss
    Gustavo Bajotto
    Department of Materials Science and Engineering, Shikumi College, Nagoya Institute of Technology, Gokiso cho, Showa Ku, Nagoya 466 8 555, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:233-47. 2006
    ....
  13. pmc Peroxisome proliferator-activated receptor α (PPARα) mRNA expression in human hepatocellular carcinoma tissue and non-cancerous liver tissue
    Tsuyoshi Kurokawa
    Masuko Memorial Hospital, Takehashi cho, Nakamura ku, Nagoya, Japan
    World J Surg Oncol 9:167. 2011
    ..There have been no reports, however, demonstrating that PPARα is involved in the development of human liver cancer...
  14. ncbi request reprint Modified method for purifying rat liver branched-chain alpha-ketoacid dehydrogenase complex
    Yukihiro Fujimura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Showa Ku, Nagoya, Japan
    Biosci Biotechnol Biochem 73:766-8. 2009
    ..Arch. Biochem. Biophys., 283, 293-299 (1990)). Here we report a modification of the method designed to obtain the purified enzyme with high reproducibility...
  15. ncbi request reprint Inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate at different potassium ionic levels
    Keiichi Akita
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan
    Biosci Biotechnol Biochem 73:1189-91. 2009
    ..2 and 16.4 microM were obtained in the presence of 20 and 100 mM K(+), respectively. These results suggest that BDK is less sensitive to TPP inhibition under physiological TPP and K(+) concentrations...
  16. ncbi request reprint Metabolism and physiological function of branched-chain amino acids: discussion of session 1
    Yoshiharu Shimomura
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, 466 8555, Japan
    J Nutr 136:232S-3S. 2006
  17. ncbi request reprint The effects of endotoxin on plasma free amino acid concentrations in rats
    Yosuke Asai
    Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:460-6. 2008
    ..These results suggest that the availability of administered BCAAs to the body tissues during sepsis is higher following parenteral than peroral administration...
  18. ncbi request reprint Dissociation of branched-chain alpha-keto acid dehydrogenase kinase (BDK) from branched-chain alpha-keto acid dehydrogenase complex (BCKDC) by BDK inhibitors
    Taro Murakami
    Department of Materials Science, Nagoya Institute of Technology, Gokiso cho, Showa Ku, Nagoya 466 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:48-50. 2005
    ..These results suggest that the dissociation of the BDK from the BCKDC is one of the mechanisms responsible for the action of some inhibitors to BDK...
  19. ncbi request reprint Quantitative analysis of cereulide, an emetic toxin of Bacillus cereus, by using rat liver mitochondria
    Kumiko Kawamura-Sato
    Department of Medical Technology, Nagoya University Graduate School of Health Science, Nagoya, Aichi, Japan
    Microbiol Immunol 49:25-30. 2005
    ..The enterotoxin of B. cereus or Staphylococcus aureus did not show any effect on the oxygen consumption, indicating this method is specific for the identification of cereulide as a causative agent of emetic food poisonings...
  20. ncbi request reprint Exercise training increases the activity of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats
    Naoya Nakai
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464 8601, Japan
    Endocr J 49:547-54. 2002
    ....
  21. ncbi request reprint Effects of liver failure on branched-chain alpha-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure
    Takashi Honda
    Therapeutic Medicine, School of Medicine, Nagoya University, Nagoya 466 8550, Japan
    J Hepatol 40:439-45. 2004
    ..We conducted an animal study to examine whether the effects on hepatic BCKDH complex differ between acute liver failure (ALF) and chronic liver failure (CLF)...
  22. ncbi request reprint Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver
    Hiroki Ishiguro
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Life Sci 79:737-43. 2006
    ..These results suggest that BCAA catabolism enhanced by clofibrate treatment has significant influences on the leucine-induced activation of translation initiation processes...
  23. ncbi request reprint Leucine-induced activation of translational initiation is partly regulated by the branched-chain alpha-keto acid dehydrogenase complex in C2C12 cells
    Naoya Nakai
    Department of Health and Sports Sciences, Graduate School of Medicine, Osaka University, Osaka 560 0043, Japan
    Biochem Biophys Res Commun 343:1244-50. 2006
    ..These results suggest that the activation of the translational regulators by leucine was partly regulated by the activity of BCKDH complex...
  24. ncbi request reprint Activation of hepatic branched-chain alpha-keto acid dehydrogenase complex by tumor necrosis factor-alpha in rats
    Makoto Shiraki
    Department of Internal Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 328:973-8. 2005
    ..These results suggest that the decrease in the bound form of kinase is involved in the mechanism responsible for TNFalpha-induced activation of the BCKDH complex...
  25. ncbi request reprint Estrogen controls branched-chain amino acid catabolism in female rats
    Mariko Obayashi
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Nutr 134:2628-33. 2004
    ..We hypothesize that the 17beta-estradiol-controlled feeding pattern produces these variations in BCKDC activity. This may function in female rats to conserve essential amino acids for protein synthesis...
  26. ncbi request reprint Increased expression of hepatic pyruvate dehydrogenase kinases 2 and 4 in young and middle-aged Otsuka Long-Evans Tokushima Fatty rats: induction by elevated levels of free fatty acids
    Gustavo Bajotto
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464 8601, Japan
    Metabolism 55:317-23. 2006
    ..These results suggest that persistently elevated levels of circulating free fatty acid in normal and diabetic OLETF rats play an important role in stimulating PDK2 and PDK4 expression in liver...
  27. ncbi request reprint Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver
    Ken ichiro Minato
    Miyagi Agricultural College, 982 0215, Sendai, Japan
    Life Sci 72:1609-16. 2003
    ..These findings showed that eriocitrin was effective in the prevention of oxidative damages caused by acute exercise-induced oxidative stress...
  28. doi request reprint Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus
    Teiji Kuzuya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 373:94-8. 2008
    ..These results suggest that BCAA catabolism in type 2 diabetes is downregulated and enhanced by BCAA supplementation...