Kiyosumi Shibata

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Cancer 7:15. 2007
  2. ncbi request reprint Neoadjuvant chemotherapy for FIGO stage III or IV ovarian cancer: Survival benefit and prognostic factors
    K Shibata
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
    Int J Gynecol Cancer 13:587-92. 2003
  3. ncbi request reprint Usefulness of preoperative chemoradiation in locally advanced cervical carcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Obstet Invest 57:93-9. 2004
  4. ncbi request reprint Expression of placental leucine aminopeptidase is associated with a poor outcome in endometrial endometrioid adenocarcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 66:288-95. 2004
  5. doi request reprint Feasibility and effectiveness of postoperative adjuvant concurrent chemoradiation therapy in Japanese patients with high-risk early-stage cancer of the uterine cervix
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Clin Oncol 13:233-8. 2008
  6. ncbi request reprint Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Oncol 95:307-13. 2004
  7. ncbi request reprint Possible involvement of adipocyte-derived leucine aminopeptidase via angiotensin II in endometrial carcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Tumour Biol 26:9-16. 2005
  8. doi request reprint Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 74:104-11. 2008
  9. pmc Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer
    Hirohisa Tsukamoto
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Cancer 8:74. 2008
  10. doi request reprint Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Gynecol Obstet Invest 71:104-11. 2011

Collaborators

Detail Information

Publications99

  1. pmc P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Cancer 7:15. 2007
    ..The aim of this study was to examine whether the malignant potential of endometrial cancer enhanced by P-LAP/IRAP is due to increased glucose uptake via the P-LAP/IRAP-mediated activation of insulin signaling...
  2. ncbi request reprint Neoadjuvant chemotherapy for FIGO stage III or IV ovarian cancer: Survival benefit and prognostic factors
    K Shibata
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
    Int J Gynecol Cancer 13:587-92. 2003
    ..A better prognosis was also associated with a higher dose intensity of cisplatin, and patients treated at >or = 18 mg/m(2)/week survived significantly longer than those receiving <18 mg/m(2)/week...
  3. ncbi request reprint Usefulness of preoperative chemoradiation in locally advanced cervical carcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Obstet Invest 57:93-9. 2004
    ..Therefore, neoadjuvant concurrent chemoradiation should be considered for treatment in patients with locally advanced cervical carcinomas who could not undergo primary operation...
  4. ncbi request reprint Expression of placental leucine aminopeptidase is associated with a poor outcome in endometrial endometrioid adenocarcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 66:288-95. 2004
    ..This study investigated whether the expression of P-LAP correlates with clinicopathologic factors and prognosis in patients with endometrial endometrioid adenocarcinoma...
  5. doi request reprint Feasibility and effectiveness of postoperative adjuvant concurrent chemoradiation therapy in Japanese patients with high-risk early-stage cancer of the uterine cervix
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Clin Oncol 13:233-8. 2008
    ....
  6. ncbi request reprint Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Oncol 95:307-13. 2004
    ..The objective of this study was to determine whether P-LAP expression affects the chemosensitivity in endometrial carcinoma patients...
  7. ncbi request reprint Possible involvement of adipocyte-derived leucine aminopeptidase via angiotensin II in endometrial carcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Tumour Biol 26:9-16. 2005
    ....
  8. doi request reprint Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 74:104-11. 2008
    ..The purpose of this study was to establish a human ovarian YST cell line to be able to identify a target for novel molecular-based therapy...
  9. pmc Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer
    Hirohisa Tsukamoto
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Cancer 8:74. 2008
    ..Recent studies have suggested that APN/CD13 plays an important role in tumor progression in several human malignancies...
  10. doi request reprint Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Gynecol Obstet Invest 71:104-11. 2011
    ..Cisplatin is used as a key drug for ovarian yolk sac tumor (YST), but relapse may occur. Details of the molecular mechanism responsible for cisplatin resistance remain unclear...
  11. ncbi request reprint Uterine smooth muscle cells increase invasive ability of endometrial carcinoma cells through tumor-stromal interaction
    Hirohisa Tsukamoto
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Clin Exp Metastasis 24:423-9. 2007
    ..Suppression of this pathway could be an effective target for the treatment of early uterine body cancer in particular...
  12. doi request reprint Effectiveness of preoperative concurrent chemoradiation therapy (CCRT) for locally advanced adenocarcinoma of cervix
    K Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Eur J Surg Oncol 35:768-72. 2009
    ..To determine the efficacy of preoperative concurrent chemoradiation therapy (CCRT) to improve the prognosis of locally advanced adenocarcinoma of the uterine cervix...
  13. ncbi request reprint A novel role for placental leucine aminopeptidase (P-LAP) as a determinant of chemoresistance in endometrial carcinoma cells
    Chihiro Kondo
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 118:1390-4. 2006
    ..These results suggest that P-LAP reduces sensitivity to anticancer drugs via inhibition of mitochondria-mediated apoptosis, and may be a molecular target for conquering anticancer drug resistance...
  14. ncbi request reprint Twist expression in patients with cervical cancer is associated with poor disease outcome
    K Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Oncol 19:81-5. 2008
    ..We examined the distribution and expression of Twist in cervical cancer to examine its clinical significance...
  15. ncbi request reprint Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 98:11-8. 2005
    ..P-LAP is also referred to as insulin-regulated membrane aminopeptidase (IRAP) associated with GLUT4-containing vesicle. The authors evaluated P-LAP and GLUT4 expression in benign, borderline, and malignant ovarian epithelia...
  16. ncbi request reprint Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Int J Cancer 122:91-9. 2008
    ..The present results suggest that there may be a link between the SDF-1alpha/CXCR4 axis and enhanced intraperitoneal dissemination of EOC and that CXCR4 may be a novel target for the treatment of EOC...
  17. doi request reprint Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model
    Norio Yoshida
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Cancer Res 14:7251-9. 2008
    ..The purpose of the present study was to clarify the functional role of IDO in human endometrial cancer cells and to investigate the therapeutic potential of IDO inhibitors...
  18. ncbi request reprint Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system
    Yoshiteru Watanabe
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Nagoya, Japan
    Clin Cancer Res 9:6497-503. 2003
    ..Enzymatic characterization demonstrated that A-LAP hydrolyzes Ang II. This study examined the role of A-LAP in angiogenesis of human endometrial carcinoma...
  19. ncbi request reprint High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary
    Noriko Takahashi
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Oncol Rep 22:1027-32. 2009
    ..001). These results suggested that GnT-V might be involved in the malignant potential of mucinous ovarian cancer...
  20. ncbi request reprint Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma
    Mikio Terauchi
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya, 466 8550, Japan
    Clin Exp Metastasis 24:329-39. 2007
    ....
  21. ncbi request reprint Stromal cell-derived factor-1alpha-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma
    Yayoi Mizokami
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Int J Cancer 110:652-9. 2004
    ..This is the first report showing a direct link between the SDF-1alpha/CXCR4 pathway with CD26/DPPIV in solid tumors, suggesting that CD26/DPPIV is likely to directly modulate various SDF-1alpha induced functions...
  22. ncbi request reprint Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity
    Tomokazu Umezu
    Department of Obstetrics and Gynecology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Hum Cell 20:71-6. 2007
    ..These results indicated that NOE cells showed similar chemosensitivity and properties to those of the original tumor and might be useful in basic studies on the diagnosis, treatment and etiology of ovarian tumors...
  23. ncbi request reprint Twist expression predicts poor clinical outcome of patients with clear cell carcinoma of the ovary
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 71:394-401. 2006
    ..We examined the distribution and expression of this molecule in clear cell carcinoma of the ovary (CCC) to elucidate their clinical significance...
  24. ncbi request reprint Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Int J Oncol 31:277-83. 2007
    ..It is possible that therapeutic benefits such as the restoration of chemosensitivity or suppression of metastasis will be enabled by gaining further insight into the mechanisms underlying chemoresistance and EMT...
  25. doi request reprint Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma
    Tomoko Inaba
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 115:185-92. 2009
    ..Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that induces immune tolerance. The purpose of the present study is to investigate IDO expression and its functional role in ovarian cancer cells in vitro and in vivo...
  26. ncbi request reprint Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo
    Mamoru Yamashita
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Int J Cancer 120:2243-50. 2007
    ..APN/CD13 may be a therapeutic target for the treatment of OVCA in combination with chemotherapy...
  27. doi request reprint Identification and characterization of cancer stem cells in ovarian yolk sac tumors
    Shiro Suzuki
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Cancer Sci 101:2179-85. 2010
    ..Our data suggest ovarian YST to be maintained by a rare fraction of cancer stem-like cells that express the cell surface marker CD133...
  28. doi request reprint Enhanced cytotoxicity with a novel system combining the paclitaxel-2'-ethylcarbonate prodrug and an HSV amplicon with an attenuated replication-competent virus, HF10 as a helper virus
    Daisuke Ishida
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya 466 8550, Japan
    Cancer Lett 288:17-27. 2010
    ..05). These results indicate that the addition of a prodrug converting enzyme may be a feasible approach to further enhance the efficacy of HF10 as a cancer therapeutics in low HF10-sensitive malignancies...
  29. ncbi request reprint Anti-progressive effect of neutral endopeptidase 24.11 (NEP/CD10) on cervical carcinoma in vitro and in vivo
    Mikio Terauchi
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Oncology 69:52-62. 2005
    ....
  30. ncbi request reprint Possible involvement of SDF-1alpha/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cells
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya, 466 8550, Japan
    Cell Tissue Res 330:221-9. 2007
    ..These results suggest that DPPIV and SDF-1alpha/CXCR4 play crucial roles in regulating the migratory potential of HPMCs, which may be involved in the re-epithelialization of denuded basement membrane at the site of peritoneal injury...
  31. doi request reprint Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor (SC-OYST) in peritoneal dissemination
    Hiroko Mitsui
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Oncol 124:303-10. 2012
    ..We investigated interactions between peritoneal mesothelial cells and SC-OYST based on the hypothesis that peritoneal mesothelial cells have the potential to provide one of the niches for SC-OYST...
  32. pmc Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells
    Mikio Terauchi
    Department of Obstetrics and Gynecology, Nagoya University, Graduate School of Medicine, Tsuruma cho 65, Showa Ku, Nagoya 466 8550, Japan
    BMC Cancer 7:140. 2007
    ..Recent studies have suggested that APN/CD13 plays an important role in tumor progression of several human malignancies. In the current study, we investigated the role of APN/CD13 in ovarian carcinoma (OVCA) progression...
  33. ncbi request reprint Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha
    Seiji Sumigama
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Oncogene 23:5496-504. 2004
    ..The present data represent the first direct evidence that AP-2alpha plays a tumor suppressive role in ovarian cancer...
  34. ncbi request reprint Oxytocin inhibits the progression of human ovarian carcinoma cells in vitro and in vivo
    Takanori Morita
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 109:525-32. 2004
    ..2 +/- 0.11 g) was significantly (p < 0.05) less than that of physiologic saline-treated group (0.5 +/- 0.54 g). This evidence implies that OT may functionally suppress peritoneal dissemination in ovarian carcinoma...
  35. ncbi request reprint Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor
    Takayasu Suganuma
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lab Invest 84:639-48. 2004
    ....
  36. ncbi request reprint Activation of invasiveness of cervical carcinoma cells by angiotensin II
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Obstet Gynecol 190:1258-63. 2004
    ..Angiotensin II recently has been reported to promote the growth of several kinds of cells. In this study, we investigated the effect of angiotensin II on cervical carcinoma cells...
  37. ncbi request reprint Functional expression of the angiotensin II type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination
    Takayasu Suganuma
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Cancer Res 11:2686-94. 2005
    ..The present study examined AT1R expression in human ovarian carcinoma and attempted to determine whether AT1R blocker could suppress the tumor progression...
  38. ncbi request reprint Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Clin Cancer Res 11:1798-808. 2005
    ..This evidence suggests that NEP functionally suppresses the progression of ovarian carcinoma and further study of this enzyme may reveal an effective way to target ET-1 for the treatment of this carcinoma...
  39. doi request reprint Is there any association between retroperitoneal lymphadenectomy and survival benefit in advanced stage epithelial ovarian carcinoma patients?
    Kotaro Sakai
    Department of Obstetrics and Gynecology, Daido Hospital, Nagoya, Japan
    J Obstet Gynaecol Res 38:1018-23. 2012
    ..The effect of systematic retroperitoneal lymphadenectomy (SRL) remains controversial in patients with advanced epithelial ovarian cancer (aEOC) who are optimally debulked...
  40. doi request reprint Survival impact of adjuvant paclitaxel and carboplatin for early-stage ovarian clear-cell carcinoma with complete surgical staging
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Obstet Invest 72:252-6. 2011
    ..The aim of this study was to estimate the survival impact of adjuvant paclitaxel and carboplatin (TC) compared to cisplatin (CDDP)-based chemotherapies for early-stage ovarian clear-cell carcinoma (CCC)...
  41. doi request reprint Taxol resistance among the different histological subtypes of ovarian cancer may be associated with the expression of class III beta-tubulin
    Tomokazu Umezu
    Department of Obstetrics and Gynecology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Int J Gynecol Pathol 27:207-12. 2008
    ..Taxol sensitivity differing among histological subtypes in EOC is associated with the expression of class III beta-tubulin...
  42. ncbi request reprint Long-term prognosis of stage I ovarian carcinoma. Prognostic importance of intraoperative rupture
    Mika Mizuno
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 65:29-36. 2003
    ..There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective of this study was to evaluate prognostic factors for long-term survival...
  43. ncbi request reprint Neutral endopeptidase/CD10 expression in the stroma of epithelial ovarian carcinoma
    Ei Ei Khin
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Gynecol Pathol 22:175-80. 2003
    ..Furthermore, stromal NEP was downregulated as the histological grade advanced. These results suggest that NEP may play a role in the regulation of neoplastic transformation and tumor differentiation in epithelial ovarian carcinomas...
  44. doi request reprint Thyroid transcription factor 1 expression in ovarian carcinomas is an independent prognostic factor
    Sawako Fujiwara
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya 466 8550, Japan
    Hum Pathol 41:560-5. 2010
    ....
  45. ncbi request reprint Irradiation-induced epithelial-mesenchymal transition (EMT) related to invasive potential in endometrial carcinoma cells
    Hirohisa Tsukamoto
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 107:500-4. 2007
    ..In this study, we hypothesized that ionizing irradiation would cause endometrial carcinoma cells (HEC1A) to undergo an increase of motility related to EMT...
  46. doi request reprint Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy
    Tomoko Inaba
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Oncol 117:423-8. 2010
    ..The present study aimed to investigate IDO expression and its prognostic significance in invasive cervical cancer...
  47. doi request reprint Survival impact of capsule rupture in stage I clear cell carcinoma of the ovary in comparison with other histological types
    Makiko Higashi
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Japan
    Gynecol Oncol 123:474-8. 2011
    ..We analyzed a large number of stage I clear cell carcinoma of the ovary (CCC) patients to estimate the survival impact of the capsule status in stage I CCC patients, particularly in comparison with non-CCC patients...
  48. doi request reprint Postrecurrent oncologic outcome of patients with ovarian clear cell carcinoma
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Gynecol Cancer 22:801-6. 2012
    ..To estimate the long-term clinical outcome of patients with recurrent clear cell carcinoma (RCCC) of the ovary in comparison with those with recurrent serous adenocarcinoma (RSAC)...
  49. doi request reprint Long-term clinical outcome of patients with recurrent epithelial ovarian carcinoma: is it the same for each histological type?
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Gynecol Cancer 22:394-9. 2012
    ..This study was conducted to estimate the long-term clinical outcome of patients with recurrent ovarian carcinoma (ROC)...
  50. doi request reprint Growth-suppressing function of glypican-3 (GPC3) via insulin like growth factor II (IGF-II) signaling pathway in ovarian clear cell carcinoma cells
    Maiko Sakurai
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Oncol 119:332-6. 2010
    ..Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is overexpressed in only CCC of epithelial ovarian carcinoma subtypes. The purpose of this study was to identify the role of GPC3 in ovarian CCC...
  51. ncbi request reprint Endometrioid adenocarcinoma arising from endometriosis during 2 years of estrogen replacement therapy after total hysterectomy and bilateral salpingo-oophorectomy
    Seiji Nomura
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Obstet Gynecol Scand 85:1019-21. 2006
  52. ncbi request reprint Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells
    Kazuhiko Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lab Invest 83:1799-809. 2003
    ..These results suggest the involvement of these aminopeptidases in invasiveness of both normal and malignant intermediate-type trophoblasts possibly through degradation of specific peptide substrates...
  53. ncbi request reprint Possible role of placental leucine aminopeptidase in the antiproliferative effect of oxytocin in human endometrial adenocarcinoma
    Yuka Suzuki
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Nagoya 466 8850, Japan
    Clin Cancer Res 9:1528-34. 2003
    ..Oxytocin (OT) was reported to inhibit the proliferation of various neoplastic tissues and cells, however, the regulation system remains unclear. This study examined the role of OT and its regulatory ability in endometrial adenocarcinoma...
  54. ncbi request reprint Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Japan
    Cancer Res 63:2278-83. 2003
    ..To our knowledge, this is the first evidence that increasing DPPIV expression may contribute to prolonged survival by up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases...
  55. ncbi request reprint Long-term follow-up and prognostic factor analysis in clear cell adenocarcinoma of the ovary
    Mika Mizuno
    Department of Obstetrics and Gynecology, Japanese Red Cross Nagoya First Hospital, Michishita, Nakamura ku, and Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Surg Oncol 94:138-43. 2006
    ..This study compared the clinical factors affecting long-term survival of patients with CCA to those with serous cystadenocarcinoma (SCA)...
  56. ncbi request reprint Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Ann N Y Acad Sci 1086:233-40. 2006
    ..This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma...
  57. doi request reprint N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin
    Eiko Yamamoto
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Endocrinology 150:990-9. 2009
    ..These results suggest that GnT-V is expressed in human EVT and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin...
  58. doi request reprint Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Hum Pathol 44:181-8. 2013
    ..This study suggested that the assessment of the Twist immunoreactivity and lymphovascular space involvement may distinguish high- from low-risk patients with locally invasive cervical carcinoma...
  59. doi request reprint Adjuvant chemotherapy for stage i ovarian clear cell carcinoma: is it necessary for stage IA?
    Mika Mizuno
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Japan
    Int J Gynecol Cancer 22:1143-9. 2012
    ..This study was designed to evaluate the postoperative outcomes associated with the inclusion or exclusion of adjuvant therapy in these patients...
  60. ncbi request reprint Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125
    Hideo Kazeto
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Tumour Biol 24:203-8. 2003
    ..Our results suggest that A-LAP is involved in endometrial cancer cell growth and differentiation. However, further studies, especially of the biological roles of A-LAP, are required to confirm this notion...
  61. doi request reprint Expression of Ret finger protein correlates with outcomes in endometrial cancer
    Hirohisa Tsukamoto
    Departments of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 100:1895-901. 2009
    ..Positive RFP expression is a predictive marker for an unfavorable clinical outcome in patients with endometrial cancer...
  62. doi request reprint The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:347-54. 2010
    ..In contrast, on Day 61, the former was smaller than the latter. The present findings show that DPPIV may be involved in the increased sensitivity to paclitaxel of EOC cells regardless of the involvement of DPPIV activity...
  63. ncbi request reprint Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy
    Seiji Nomura
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine Nagoya, 466 8550, Japan
    Biochim Biophys Acta 1751:19-25. 2005
    ..P-LAP/OTase may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as OT and vasopressin...
  64. ncbi request reprint Dipeptidyl peptidase IV in tumor progression
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Biochim Biophys Acta 1751:45-51. 2005
    ..These findings imply that DPPIV may functionally suppress peritoneal dissemination and progression of ovarian carcinoma by regulating the expression levels of several molecules associated with carcinoma cell invasion and progression...
  65. doi request reprint Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma
    Osamu Maeda
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 130:113-21. 2012
    ..Thus spectrin βII may be a useful predictor of platinum sensitivity in ovarian serous adenocarcinoma...
  66. ncbi request reprint Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in human placental explant cultures
    Masako Araki-Taguchi
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Life Sci 82:59-67. 2008
    ..Data presented herein suggest a possible role for Ang II in impairing trophoblast differentiation toward an invasive phenotype, which might be associated with shallow invasion in preeclamptic placentas...
  67. ncbi request reprint Clinical characteristics and prognosis of mucinous tumors of the ovary
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 103:171-5. 2006
    ..In this study, we compared the clinical characteristics and prognosis among these 3 types of mucinous tumors...
  68. ncbi request reprint Survival time and invasive activity due to dipeptidyl peptidase IV overexpression in ovarian carcinoma
    Shigehiko Mizutani
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Adv Exp Med Biol 524:253-6. 2003
  69. doi request reprint Fertility-sparing surgery in young women with mucinous adenocarcinoma of the ovary
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 122:334-8. 2011
    ..The purpose of this study was to clarify the clinical outcome of patients with stage IA mucinous epithelial ovarian cancer (mEOC) treated with fertility-sparing surgery (FSS)...
  70. ncbi request reprint Long-term outcome and prognostic factors for yolk sac tumor of the ovary
    Tomokazu Umezu
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Nagoya J Med Sci 70:29-34. 2008
    ..In conclusion, the FIGO (International Federation of Gynecology and Obstetrics) stage, ascites volume and residual tumor size tended to affect the prognosis of YST...
  71. doi request reprint Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Oncol 111:523-6. 2008
    ..The purpose of this study was to clarify the clinical outcome of patients with clear-cell carcinoma of the ovary (CCC) who would usually undergo radical surgery...
  72. ncbi request reprint Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade
    Ei Ei Khin
    Departments of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Japan
    Am J Obstet Gynecol 188:670-6. 2003
    ..Dipeptidyl peptidase IV (DPPIV)/CD26 is a cell surface aminopeptidase. This study investigated the expression and localization of DPPIV in endometrial endometrioid adenocarcinomas of different grades...
  73. ncbi request reprint Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Cancer Res 62:2753-7. 2002
    ..9 +/- 4.7, 35.7 +/- 2.8, and 36.6 +/- 1.8 days, respectively). This evidence implies that DPPIV may functionally suppress peritoneal dissemination in ovarian carcinoma...
  74. ncbi request reprint Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway
    T Suzuki
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Placenta 23:475-82. 2002
    ..Our findings also suggest that NEP/CD10 may play a functional role in the process of trophoblast differentiation...
  75. ncbi request reprint Adhesion potency to mesothelial cells by overexpression of dipeptidyl peptidase IV
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Adv Exp Med Biol 524:249-52. 2003
  76. ncbi request reprint Preoperative findings in non-gynecologic carcinomas metastasizing to the ovaries
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Obstet Invest 54:221-7. 2002
    ..CEA is a useful marker to distinguish non-gynecologic from primary ovarian carcinoma, while CA125 is the only significant prognostic marker for non-gynecologic ovarian carcinoma...
  77. ncbi request reprint Increased adhesion potency of ovarian carcinoma cells to mesothelial cells by overexpression of dipeptidyl peptidase IV
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 105:779-83. 2003
    ..In conclusion, ovarian carcinoma cells express DPPIV and adhere to human mesothelial cells in part by DPPIV. This adhesion mechanism of DPPIV is mediated by immobilized and soluble fibronectin...
  78. doi request reprint Glypican-3 expression predicts poor clinical outcome of patients with early-stage clear cell carcinoma of the ovary
    Tomokazu Umezu
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Clin Pathol 63:962-6. 2010
    ..However, in CCC patients, the relationship between the overexpression of GPC3 and prognosis has not yet been clarified...
  79. ncbi request reprint Expression of CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma and its negative correlation with tumor grade
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Adv Exp Med Biol 524:245-8. 2003
  80. ncbi request reprint Manipulating the angiotensin system--new approaches to the treatment of solid tumours
    Kazuhiko Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Expert Opin Biol Ther 6:243-55. 2006
    ....
  81. ncbi request reprint Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies
    Kazuhiko Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biol Chem 385:683-90. 2004
    ..Thus, membrane-bound peptidases may become not only a new diagnostic/prognostic marker, but also a novel molecular target for the treatment of gynecologic malignancies...
  82. doi request reprint Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: its association with disease progression and survival
    Kazuhiko Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Cancer Res 14:2310-7. 2008
    ..The purpose of the present study was to investigate the relationship between IDO expression and tumor-infiltrating lymphocytes (TIL) or natural killer (NK) cells and to clarify their prognostic effect in endometrial cancer...
  83. doi request reprint Intra-amniotic infection increases amniotic lamellar body count before 34 weeks of gestation
    Hiroyuki Tsuda
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
    J Matern Fetal Neonatal Med 23:1230-6. 2010
    ..To examine the lamellar body count (LBC) value in intra-amniotic infection cases and evaluate its association with the incidence of respiratory distress syndrome (RDS)...
  84. doi request reprint Fertility-sparing surgery in young women with invasive epithelial ovarian cancer
    H Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Eur J Surg Oncol 36:404-8. 2010
    ..The purpose of this study was to clarify the clinical outcome of patients with stage IA or more advanced epithelial ovarian cancer (EOC) treated with fertility-sparing surgery (FSS)...
  85. pmc Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis
    E Yamamoto
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Br J Cancer 97:1538-44. 2007
    ....
  86. pmc Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival
    K Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Br J Cancer 94:552-60. 2006
    ..These results demonstrated that AT1R correlated with tumour angiogenesis and poor patient outcome in ovarian cancer, suggesting its clinical potential for a novel molecular target in strategies for ovarian cancer treatment...
  87. ncbi request reprint Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells
    F Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Placenta 25:176-83. 2004
    ..In conclusion, GnRH induces NEP expression by PKC delta and p38MAPK, and increased NEP expression may be involved in antiproliferative effect in BeWo cells...
  88. pmc Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer
    K Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Br J Cancer 95:1555-61. 2006
    ....
  89. pmc Expression of Twist increases the risk for recurrence and for poor survival in epithelial ovarian carcinoma patients
    S Hosono
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya, Japan
    Br J Cancer 96:314-20. 2007
    ..0001). Positive Twist expression seems to be a useful marker in patients with EOC likely to have an unfavourable clinical outcome...
  90. ncbi request reprint Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma
    S Arita
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Gynecol Cancer 15:329-36. 2005
    ..102). In conclusion, VEGF and its receptors are suggested to be involved in progression of uterine sarcoma, but only the p-flt-1 level significantly affected the survival of leiomyosarcoma patients...
  91. doi request reprint Is there any association between retroperitoneal lymphadenectomy and survival benefit in ovarian clear cell carcinoma patients?
    S Suzuki
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Oncol 19:1284-7. 2008
    ..To estimate the survival impact of systemic retroperitoneal lymphadenectomy in patients diagnosed with International Federation of Gynecology and Obstetrics pTI-IIb clear cell carcinoma of the ovary (CCC)...
  92. ncbi request reprint Excretion of bikunin and its fragments in the urine of patients with renal stones
    M Suzuki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Urol 166:268-74. 2001
    ..CONCLUSIONS: If urinary bikunin is important in the pathogenesis of urolithiasis, its effect is probably attributable to the concentration and degree of glycosylation...
  93. ncbi request reprint Effects of lifestyle factors on ultrasonographically determined bone health in Japanese women
    M Fukuharu
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan
    Public Health 115:146-51. 2001
    ..These results support the effectiveness of exercise begun in adulthood. Having a good exercise habit is one of the most effective ways of maintaining good bone health...
  94. ncbi request reprint Changes of urinary 8-hydroxydeoxyguanosine levels during a two-day ultramarathon race period in Japanese non-professional runners
    M Miyata
    Department of Health, Promotion, and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Int J Sports Med 29:27-33. 2008
    ..Extreme prolonged exercise in a two-day ultramarathon race period causes oxidative DNA damage but antioxidant repair systems are apparently induced to protect against oxidative DNA stress with physical exercise...
  95. ncbi request reprint Advances in treatment of epithelial ovarian cancer
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Nagoya J Med Sci 68:19-26. 2006
    ..The effectiveness of neoadjuvant chemotherapy and interval debulking surgery still remains unclear. This review will describe the advances in surgical procedures and chemotherapy in treatment of ovarian cancer patients...
  96. ncbi request reprint Essential role of placental leucine aminopeptidase in gynecologic malignancy
    Shigehiko Mizutani
    Nagoya University School of Medicine, Department of Medical Science of Proteases, Nagoya, Japan
    Expert Opin Ther Targets 11:453-61. 2007
    ..In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review...
  97. ncbi request reprint Gene directed enzyme prodrug therapy for ovarian cancer: could GDEPT become a promising treatment against ovarian cancer?
    Akihiro Nawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya 466 8550, Japan
    Anticancer Agents Med Chem 8:232-9. 2008
    ..Finally, this review focuses on the development, application and potential of various GDEPTs for treating ovarian cancer, and the scope and progress of new GDEPTs are discussed...
  98. ncbi request reprint Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway
    Kazuhiko Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Clin Endocrinol Metab 88:3973-82. 2003
    ..These observations suggest the possible regulatory mechanism by the local renin-angiotensin system, especially the Ang II-AT(1)R-APA system, for the growth of human choriocarcinoma cells...
  99. ncbi request reprint Cushing's syndrome due to ovarian serous adenocarcinoma secreting multiple endocrine substances: a case report and immunohistochemical analysis
    Takahiro Suzuki
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 90:662-6. 2003
    ..Although Cushing's syndrome arises from various neuroendocrine tumors secreting adrenocorticotropin (ACTH) ectopically, ovarian carcinoma rarely causes this syndrome...