Kazunobu Sawamoto

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. pmc Neuronal regeneration in a zebrafish model of adult brain injury
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Dis Model Mech 5:200-9. 2012
  2. pmc Strategies for regenerating striatal neurons in the adult brain by using endogenous neural stem cells
    Kanako Nakaguchi
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Neurol Res Int 2011:898012. 2011
  3. pmc Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain
    Kanako Nakaguchi
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Aichi 467 8601, Nagoya, Japan
    Stem Cells Int 2012:915160. 2012
  4. pmc A subtype-specific critical period for neurogenesis in the postnatal development of mouse olfactory glomeruli
    Yasuko Kato
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    PLoS ONE 7:e48431. 2012
  5. pmc Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil
    Junichi Yamane
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Mol Brain 4:35. 2011
  6. pmc Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus
    Yoichi Imaizumi
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Mol Brain 4:7. 2011
  7. ncbi request reprint Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain
    Kazunobu Sawamoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
    J Comp Neurol 519:690-713. 2011
  8. doi request reprint Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum
    Takuro Kojima
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Stem Cells 28:545-54. 2010
  9. doi request reprint Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nat Neurosci 16:884-8. 2013
  10. doi request reprint Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb
    Yuki Hirota
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Stem Cells 30:1726-33. 2012

Collaborators

Detail Information

Publications33

  1. pmc Neuronal regeneration in a zebrafish model of adult brain injury
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Dis Model Mech 5:200-9. 2012
    ..These results suggest that the telencephalic VZ contributes to neural tissue recovery following telencephalic injury in the adult zebrafish, and that the adult zebrafish is a useful model for regenerative medicine...
  2. pmc Strategies for regenerating striatal neurons in the adult brain by using endogenous neural stem cells
    Kanako Nakaguchi
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Neurol Res Int 2011:898012. 2011
    ..Here, we review current knowledge on the generation of new neurons in the adult brain and discuss their potential for use in replacing striatal neurons lost to neurodegenerative diseases, including HD, and to ischemic stroke...
  3. pmc Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain
    Kanako Nakaguchi
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Aichi 467 8601, Nagoya, Japan
    Stem Cells Int 2012:915160. 2012
    ....
  4. pmc A subtype-specific critical period for neurogenesis in the postnatal development of mouse olfactory glomeruli
    Yasuko Kato
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    PLoS ONE 7:e48431. 2012
    ..This study provides new insights into the mechanisms of postnatal neurogenesis and a biological basis for the therapeutic effect of olfactory training...
  5. pmc Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil
    Junichi Yamane
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Mol Brain 4:35. 2011
    ..This study provides evidence for a potential application of hGal1 with hNSPCs-transplantation in the treatment of brain ischemia...
  6. pmc Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus
    Yoichi Imaizumi
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Mol Brain 4:7. 2011
    ..However, little is known about its detailed expression profile in the NPCs and functions in adult neurogenesis in the DG...
  7. ncbi request reprint Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain
    Kazunobu Sawamoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
    J Comp Neurol 519:690-713. 2011
    ..This basic description of the adult and neonatal marmoset SVZ will be useful for future studies on adult neurogenesis in primates...
  8. doi request reprint Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum
    Takuro Kojima
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Stem Cells 28:545-54. 2010
    ..These findings suggest that blood vessels play an important role as a scaffold for NPCs migration toward the damaged brain region...
  9. doi request reprint Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nat Neurosci 16:884-8. 2013
    ..Our findings suggest that olfactory input generates interhemispheric differences in the fate of adult-born neurons in the zebrafish brain. ..
  10. doi request reprint Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb
    Yuki Hirota
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Stem Cells 30:1726-33. 2012
    ....
  11. ncbi request reprint [Neuronal migration in the adult brain]
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:63-8. 2008
    ..Understanding more precise and comprehensive mechanisms of adult neurogenesis should lead to future development of regenerative therapies for neuropsychiatric diseases...
  12. doi request reprint Migration of neuronal precursors from the telencephalic ventricular zone into the olfactory bulb in adult zebrafish
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Comp Neurol 519:3549-65. 2011
    ..This is the first evidence for the tangential migration of neuronal precursors in a nonmammalian adult telencephalon...
  13. doi request reprint Subventricular zone-derived oligodendrogenesis in injured neonatal white matter in mice enhanced by a nonerythropoietic erythropoietin derivative
    Eisuke Kako
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Stem Cells 30:2234-47. 2012
    ..These results demonstrate the limitation and potential of endogenous OPCs in the pSVZ as a therapeutic target for treating neonatal white-matter injury...
  14. pmc New neurons clear the path of astrocytic processes for their rapid migration in the adult brain
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Neuron 67:213-23. 2010
    ..Through this neuron-glia interaction, the new neurons regulate the formation of the astrocytic meshwork that is needed to enable their rapid and directional migration in adult brain...
  15. ncbi request reprint Rac1-mediated indentation of resting neurons promotes the chain migration of new neurons in the rostral migratory stream of post-natal mouse brain
    Takao Hikita
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Neurochem 128:790-7. 2014
    ..These results suggest that Rac1 regulates a morphological change in the resting neurons, which allows them to serve as a migratory scaffold, and thereby non-cell-autonomously promotes chain migration...
  16. ncbi request reprint Mechanisms of neurogenesis in the normal and injured adult brain
    Masato Sawada
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
    Keio J Med 62:13-28. 2013
    ..Some of these findings were presented in the Kitazato Prize Lecture at Keio University School of Medicine in 2011...
  17. doi request reprint Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II
    Yuki Hirota
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Development 137:3037-46. 2010
    ..This study demonstrates that the orientation and distribution of basal bodies occur by distinct mechanisms...
  18. ncbi request reprint Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb
    Masato Sawada
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Neurosci 31:11587-96. 2011
    ..Our results suggest that olfactory-experience-dependent modification of neuronal turnover confers structural plasticity and stability on the olfactory bulb...
  19. doi request reprint Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain
    Makiko Ikeda
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Stem Cells 28:2017-26. 2010
    ..Conversely, the knockdown of Diversin decreased the proliferation of neuroblasts. Our results indicate that Diversin plays an important role in the proliferation of neuroblasts in the SVZ of the adult brain...
  20. ncbi request reprint [Neuronal migration in the adult brain]
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:215-8. 2007
    ..Although there are a lot of subjects to be elucidated, understanding the comprehensive mechanism of adult neurogenesis should be useful for developing successful regenerative therapies for neuropsychological diseases in the future...
  21. ncbi request reprint [Adult neurogenesis in physiological and pathological conditions]
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Brain Nerve 60:319-28. 2008
    ..For development of successful regenerative medicine for injured brain, we need to understand more precise and comprehensive mechanisms regulating adult neurogenesis...
  22. ncbi request reprint [Endogenous repair mechanisms in the brain]
    Kazunobu Sawamoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences
    Rinsho Shinkeigaku 49:830-3. 2009
    ....
  23. ncbi request reprint [Regenerating neurons by using endogenous neuronal progenitor cells]
    Kazunobu Sawamoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences
    Rinsho Shinkeigaku 52:939-41. 2012
    ..Here, we review current knowledge on the generation of new neurons in the adult brain and discuss their potential for use in replacing neurons lost to neurodegenerative diseases, including ALS, and to ischemic stroke...
  24. doi request reprint Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain
    Haruko Ota
    Department of Developmental and Regenerative Biology, Nagoya City University, Graduate School of Medical Sciences, Aichi, Japan Department of Anesthesiology and Medical Crisis Management, Nagoya City University, Graduate School of Medical Sciences, Aichi, Japan
    Biochem Biophys Res Commun 442:16-21. 2013
    ..Our results suggest that Girdin and Girdin-interacting proteins control neuronal migration by regulating actin and/or microtubule dynamics. ..
  25. ncbi request reprint Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone
    Yuki Hirota
    Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Neurosci 27:12829-38. 2007
    ..These findings suggest that Cdk5 plays an important role in neuroblast migration in the postnatal subventricular zone...
  26. doi request reprint Planar polarity of ependymal cilia
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Differentiation 83:S86-90. 2012
    ..The ciliary basal bodies' anterior position on the apical surface of the cell is determined in the embryonic radial glial cells, inherited by ependymal cells, and established by non-muscle myosin II in early postnatal development...
  27. ncbi request reprint [Neurogenesis in the adult subventricular zone]
    Yuki Hirota
    Tanpakushitsu Kakusan Koso 53:863-9. 2008
  28. doi request reprint Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice
    Mari Yamagata
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Stroke 44:551-4. 2013
    ..So far, no effective treatment for HI brain injury has been developed. In this study, we investigated the therapeutic effects of stem cells from human exfoliated deciduous teeth (SHED) for the treatment of neonatal HI brain injury...
  29. ncbi request reprint Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury
    Shin Kato
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    J Neurosci Res 89:1566-74. 2011
    ..Our present finding of an interaction between astrocytes and OPCs may lead to a new therapeutic approach to OPCs for use against cellular stress and injury...
  30. ncbi request reprint Adult neurogenesis and its alteration under pathological conditions
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Nagoya City University, Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Neurosci Res 63:155-64. 2009
    ..To develop successful regenerative treatments for the injured brain, we need to understand more precisely and comprehensively the mechanisms regulating adult neurogenesis under both physiological and pathological conditions...
  31. pmc Various facets of vertebrate cilia: motility, signaling, and role in adult neurogenesis
    Shihhui Huang
    Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 85:324-36. 2009
    ..Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body...