Hidefumi Sasaki

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. doi request reprint Usefulness of immunohistochemistry for the detection of the BRAF V600E mutation in Japanese lung adenocarcinoma
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Electronic address
    Lung Cancer 82:51-4. 2013
  2. pmc RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer
    Hidefumi Sasaki
    Department of Oncology, Immunology, and Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan
    Cancer Med 1:68-75. 2012
  3. doi request reprint MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Mol Med Rep 6:705-8. 2012
  4. doi request reprint Overexpression of GLUT1 correlates with Kras mutations in lung carcinomas
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery, Nagoya City University, Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Mol Med Rep 5:599-602. 2012
  5. doi request reprint Increased FGFR1 copy number in lung squamous cell carcinomas
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Mol Med Rep 5:725-8. 2012
  6. ncbi request reprint EGFRvIII mutation in lung cancer correlates with increased EGFR copy number
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 467 8601, Japan
    Oncol Rep 17:319-23. 2007
  7. ncbi request reprint Angioarrestin mRNA expression in early-stage lung cancers
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Eur J Surg Oncol 29:649-53. 2003
  8. ncbi request reprint Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Oncol Rep 18:623-8. 2007
  9. ncbi request reprint Elevated serum epidermal growth factor receptor level is correlated with lymph node metastasis in lung cancer
    Hidefumi Sasaki
    Second Department of Surgery, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Int J Clin Oncol 8:79-82. 2003
  10. ncbi request reprint Uncommon V599E BRAF mutations in Japanese patients with lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Nagoya 467 8601, Japan
    J Surg Res 133:203-6. 2006

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. doi request reprint Usefulness of immunohistochemistry for the detection of the BRAF V600E mutation in Japanese lung adenocarcinoma
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Electronic address
    Lung Cancer 82:51-4. 2013
    ..The usefulness of immunohistochemistry (IHC) as a new approach for the detection of BRAF V600E in cancer patients has been recently reported...
  2. pmc RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer
    Hidefumi Sasaki
    Department of Oncology, Immunology, and Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan
    Cancer Med 1:68-75. 2012
    ..This method facilitates the molecular evaluation for RET fusions and could be applicable in clinical practice to detect lung cancer that may be responsive to RET inhibitors...
  3. doi request reprint MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Mol Med Rep 6:705-8. 2012
    ..598±2.373) than in wild-type NRF2 mutants (0.734±0.820; p=0.0002). These data support the hypothesis that the expression of MRP3 is induced by NRF2 activation in lung squamous cell cancers...
  4. doi request reprint Overexpression of GLUT1 correlates with Kras mutations in lung carcinomas
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery, Nagoya City University, Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Mol Med Rep 5:599-602. 2012
    ..0009). Thus, GLUT-1 overexpression correlates with an aggressive phenotype of lung carcinoma...
  5. doi request reprint Increased FGFR1 copy number in lung squamous cell carcinomas
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Mol Med Rep 5:725-8. 2012
    ..Thus, the FGFR1 copy number is common within squamous cell carcinoma...
  6. ncbi request reprint EGFRvIII mutation in lung cancer correlates with increased EGFR copy number
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 467 8601, Japan
    Oncol Rep 17:319-23. 2007
    ..284+/-1.224) (p=0.0001). EGFRvIII gene mutation might be one of the mechanisms of increased EGFR copy number. Further studies are needed to confirm the mechanisms of EGFRvIII mutations for possible anti-EGFR therapy for lung cancer...
  7. ncbi request reprint Angioarrestin mRNA expression in early-stage lung cancers
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Eur J Surg Oncol 29:649-53. 2003
    ..We attempted to determine the influence of angioarrestin expression on clinicopathological features in patients with lung cancer who had undergone surgery...
  8. ncbi request reprint Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Oncol Rep 18:623-8. 2007
    ..Further studies are needed to confirm the mechanisms of Nras mutations for the sensitivity of molecular target therapy for lung cancer...
  9. ncbi request reprint Elevated serum epidermal growth factor receptor level is correlated with lymph node metastasis in lung cancer
    Hidefumi Sasaki
    Second Department of Surgery, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Int J Clin Oncol 8:79-82. 2003
    ..Using an enzyme immunoassay for epidermal growth factor receptor (EGFR), we investigated whether serum EGFR levels could be used as predictors of the development and extent of lung cancer...
  10. ncbi request reprint Uncommon V599E BRAF mutations in Japanese patients with lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Nagoya 467 8601, Japan
    J Surg Res 133:203-6. 2006
    ..Although a few Caucasian lung cancer patients harbored BRAF mutations, there have been no reports about the BRAF mutation in Japanese patients with lung cancer...
  11. ncbi request reprint Cten mRNA expression was correlated with tumor progression in lung cancers
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Lung Cancer 40:151-5. 2003
    ..Thus cten/GAPDH mRNA expression has been correlated with evidence of tumor progression in terms of T and overall stage of lung cancer. Alternatively, cell motility or migration might play a role in progression of lung cancer...
  12. ncbi request reprint ErbB4 expression and mutation in Japanese patients with lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Clin Lung Cancer 8:429-33. 2007
    ..Recently, erbB4 kinase domain mutations were reported in Korean patients with lung cancer. We hypothesized that erbB4 mutations correlate with clinicopathologic features of lung cancers...
  13. ncbi request reprint EGFR exon 20 insertion mutation in Japanese lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Lung Cancer 58:324-8. 2007
    ..3%, p=0.0996) and female (female 4.5% versus male 1.3%, p=0.0917). Two exon 20 insertion cases were treated with gefitinib and failed to response. EGFR insertion mutation in exon 20 could not be ignored from Japanese lung cancers...
  14. ncbi request reprint Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer
    Hidefumi Sasaki
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, MA, USA
    Breast Cancer Res Treat 77:245-52. 2003
    ..In fact, we found by in situ RNA hybridization, that the periostin gene was highly expressed in the stromal cells immediately surrounding the tumor, but not within the breast cancer cells themselves...
  15. ncbi request reprint CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Clin Lung Cancer 8:493-6. 2007
    ..Recently, it has been reported that cyclin D1 expression was increased in EGFR mutant cell lines; however, the expression status of CCND1 in EGFR mutant lung cancer tissues has not been reported...
  16. ncbi request reprint FHIT mRNA expression in thymoma
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Eur J Surg Oncol 29:904-7. 2003
    ..2 a region frequently lost in multiple tumour types. Loss of FHIT expression has been found to occur frequently in multiple tumour types. We wished to investigate that FHIT mRNA levels in a series of thymomas...
  17. ncbi request reprint Cten mRNA expression is correlated with tumor progression in thymoma
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Tumour Biol 24:271-4. 2003
    ..905 +/- 0.811; p = 0.0187). Cten/GAPDH mRNA expression was correlated with evidence of tumor progression in thymoma. Consequently, cell motility or migration might play a role in progression of thymoma...
  18. ncbi request reprint Right partial anomalous pulmonary venous connection found during lobectomy for coexisting lung cancer and tuberculosis: report of a case
    Hidefumi Sasaki
    Department of Surgery, National Kinki Central Hospital, Sakai, Osaka, Japan
    Clin Lung Cancer 7:350-2. 2006
    ..An upper lobectomy for coexisting lung cancer and tuberculosis with ligation of the partial anomalous pulmonary venous connection was successfully performed...
  19. ncbi request reprint EGFR and erbB2 mutation status in Japanese lung cancer patients
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Int J Cancer 118:180-4. 2006
    ..However, erbB2 mutation is rare from Japanese lung cancer and is of limited value for molecular target therapy...
  20. ncbi request reprint Decreased fragile histidine triad gene messenger RNA expression in lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Clin Lung Cancer 7:412-6. 2006
    ..We have investigated FHIT messenger RNA (mRNA) levels and other clinicopathologic data, including FHIT and p21 expression in lung cancer...
  21. ncbi request reprint EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Clin Cancer Res 11:2924-9. 2005
    ..However, DNA sequencing using the PCR methods described to date is time-consuming and requires significant quantities of DNA; thus, this existing approach is not suitable for a routine pretherapeutic screening program...
  22. ncbi request reprint Arg and DAP3 expression was correlated with human thymoma stage
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Clin Exp Metastasis 21:507-13. 2004
    ..The combined use of oligonucleotide microarray and real-time RT-PCR analyses provided a candidate molecular marker surrounding the development and progression of thymoma correlated with chromosome 1q...
  23. ncbi request reprint Histone deacetylase 1 mRNA expression in lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Lung Cancer 46:171-8. 2004
    ..Using the LightCycler RT-PCR assay, the HDAC1 gene expression might correlate with progression of lung cancers. However, further studies are needed to confirm the impact of HDAC1 for the molecular target of the lung cancer...
  24. ncbi request reprint Decreased Hrad6B expression in lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Acta Oncol 43:585-9. 2004
    ..Thus decreased Hrad6B mRNA expression might be a biomarker for decreased DNA repair capacity and the dysfunction of Hrad6B might play a role in the tobacco-related oncogenesis of lung cancer...
  25. ncbi request reprint Decreased kallikrein 11 messenger RNA expression in lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Clin Lung Cancer 8:45-8. 2006
    ..A recently developed method for measuring hK11 suggested that the hK11 level was an indicator of favorable prognosis in patients with ovarian cancer. We have investigated hK11 messenger RNA (mRNA) levels in lung cancer...
  26. ncbi request reprint L858R EGFR mutation status correlated with clinico-pathological features of Japanese lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Lung Cancer 54:103-8. 2006
    ..The EGFR mutation status, especially L858R mutation might be correlated with the clinico-pathological features related to good response to gefitinib, such as gender, smoking history, and pathological subtypes of Japanese lung cancers...
  27. ncbi request reprint Human MOB1 expression in non-small-cell lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Japan
    Clin Lung Cancer 8:273-6. 2007
    ..We hypothesized that hMOB1 might be expressed in non-small-cell lung cancer (NSCLC)...
  28. ncbi request reprint Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Cancer Res Clin Oncol 134:569-77. 2008
    ..The EGFR mutation status, especially exon19 mutation was correlated with good response to gefitinib than exon 21 point mutation...
  29. doi request reprint EGFR R497K polymorphism is a favorable prognostic factor for advanced lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    J Cancer Res Clin Oncol 135:313-8. 2009
    ..On other hand, EGFR gene mutations at kinase domain in non-small cell lung cancer (NSCLC) have been examined for their ability to predict sensitivity to gefitinib or erlotinib...
  30. doi request reprint MEK1 and AKT2 mutations in Japanese lung cancer
    Hidefumi Sasaki
    Department of Oncology, Immunology and Surgery II, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Thorac Oncol 5:597-600. 2010
    ....
  31. ncbi request reprint Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Clin Oncol 31:532-5. 2001
    ..5, could contribute to the uncontrolled growth of somatic cells that is a hallmark of cancer. We hypothesized that PGP9.5 may be expressed in tumors of patients with non-small cell lung cancer (NSCLC)...
  32. ncbi request reprint CHRNA5 gene D398N polymorphism in Japanese lung adenocarcinoma
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    J Surg Res 162:75-8. 2010
    ..The site was a highly conserved in the second cellular loop of the nicotinic acetylcholine receptor subunit protein...
  33. ncbi request reprint Expression of the prothymosin alpha mRNA correlated with that of N-myc in neuroblastoma
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Japan
    Cancer Lett 168:191-5. 2001
    ..3007), or stage. The prothymosin alpha mRNA expression levels were correlated with N-myc mRNA levels (P=0.006). Thus we suggest that prothymosin alpha plays an active role as a target of N-myc in neuroblastoma...
  34. ncbi request reprint Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer 92:843-8. 2001
    ..Periostin has a typical signal peptide at the N-terminal end, which suggests that it is a secreted protein. Recently, the authors developed a novel sandwich chemiluminescence assay to determine serum concentrations of periostin...
  35. doi request reprint Evaluation of Kras gene mutation and copy number gain in non-small cell lung cancer
    Hidefumi Sasaki
    Department of Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Thorac Oncol 6:15-20. 2011
    ..Recent studies for the characterization of the lung cancer genome have suggested that Kras gene was frequently amplified and correlated with activating mutations of Kras, which occur in approximately 5 to 10% of Japanese lung cancers...
  36. ncbi request reprint Expression of the MTA1 mRNA in thymoma patients
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Lett 174:159-63. 2001
    ..746+/-3.292, P=0.072). Thus our results show that the expression of the MTA1 gene is closely related to invasiveness in thymoma. The gene MTA1 could potentially provide information on the mechanism of tumor invasion and metastasis...
  37. ncbi request reprint Expression of the cdc25B gene as a prognosis marker in non-small cell lung cancer
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Japan
    Cancer Lett 173:187-92. 2001
    ..However, the NSCLC patients with high cdc25B expression had significantly poor survival than the patients with low cdc25B expression (P=0.0173). Thus we suggest that cdc25B may predict poor survival...
  38. ncbi request reprint Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Lett 172:37-42. 2001
    ..However the serum periostin level of stage IV patients (1497.0+/-285.8 ng/ml) was significantly higher than normal control (P=0.0460). These data suggest that serum periostin level may indicate tumor invasion and progression of thymoma...
  39. doi request reprint Epidermal growth factor receptor gene amplification in surgical resected Japanese lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Lung Cancer 64:295-300. 2009
    ..A high EGFR gene copy number might have shorter survival in NSCLC...
  40. ncbi request reprint Expression of the MTA1 mRNA in advanced lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Lung Cancer 35:149-54. 2002
    ..0169). Our results show that the expression of the MTA1 gene is closely related to invasiveness and metastasis in NSCLC. The gene MTA1 could thus potentially provide information on the mechanism of cancer invasion and metastasis...
  41. ncbi request reprint Expression of the sensitive to apoptosis gene, SAG, as a prognostic marker in nonsmall cell lung cancer
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Int J Cancer 95:375-7. 2001
    ..8) had significantly poorer survival than the patients with low SAG/GAPDH expression (<1.8, p = 0.0227). Thus we suggest that SAG gene expression in NSCLC may be a useful prognostic marker...
  42. ncbi request reprint Gene expression analysis of human thymoma correlates with tumor stage
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Int J Cancer 101:342-7. 2002
    ..type B1, B2 or AB). The combined use of oligonucleotide microarray and real-time RT-PCR analyses provides a powerful new approach to elucidate the in vivo molecular events correlated with tumor stage of thymoma...
  43. doi request reprint A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Cancer Res Clin Oncol 134:1371-6. 2008
    ..Mutations of the epidermal growth factor receptor (EGFR) gene at kinase domain have been reported in non-small-cell lung cancer (NSCLC). However, EGFR mutations status at C-terminal domain has not been reported in detail...
  44. doi request reprint EGFR polymorphism of the kinase domain in Japanese lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    J Surg Res 148:260-3. 2008
    ..However, EGFR mutations at exon 20 have been reported to predict resistance to gefitinib therapy...
  45. ncbi request reprint Beta IGH3, a TGF-beta inducible gene, is overexpressed in lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Jpn J Clin Oncol 32:85-9. 2002
    ..beta IGH3, TGF-beta inducible gene, was originally isolated from lung adenocarcinoma cell line (A549). We have hypothesized that beta IGH3 mRNA levels could be predictors of the development and invasion of lung cancer...
  46. ncbi request reprint Decreased perioxisome proliferator-activated receptor gamma gene expression was correlated with poor prognosis in patients with lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Lung Cancer 36:71-6. 2002
    ..However, further studies and a longer follow up are needed to confirm the impact of PPARgamma in the biological behavior of the tumor...
  47. doi request reprint AKT1 and AKT2 mutations in lung cancer in a Japanese population
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Mol Med Report 1:663-6. 2008
    ..This study demonstrated that mutations in the kinase domain of AKT2 occur in a small percentage of Japanese patients with lung cancer, while E17K AKT1 mutations do not occur at all...
  48. doi request reprint Thymoma with dissemination: efficacy of macroscopic total resection of disseminated nodules
    Motoki Yano
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    World J Surg 33:1425-31. 2009
    ..Advanced thymomas with disseminated nodules are difficult to manage, and the treatment strategy remains undefined...
  49. ncbi request reprint Evaluation of the epidermal growth factor receptor gene mutation and copy number in non-small cell lung cancer with gefitinib therapy
    Katsuhiko Endo
    Department of Surgery II, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Oncol Rep 16:533-41. 2006
    ..In conclusion, EGFR mutation was a better predictor of clinical outcome in gefitinib-treated patients than the EGFR gene copy number...
  50. doi request reprint Preservation of phrenic nerve involved by stage III thymoma
    Motoki Yano
    Department of Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Ann Thorac Surg 89:1612-9. 2010
    ..However, inclusion of the phrenic nerve (PN) in the resection may compromise pulmonary function which may be critical for the patients with serious complications...
  51. doi request reprint Thymic carcinoma with dissemination: a retrospective analysis of ten patients
    Motoki Yano
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Japan
    Gen Thorac Cardiovasc Surg 56:335-9. 2008
    ..Thymic carcinoma is a rare mediastinal neoplasm with frequent pleural or pericardial dissemination. We retrospectively studied ten such cases and analyzed factors that influenced the survival of the patients...
  52. ncbi request reprint Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay
    Katsuhiko Endo
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Lung Cancer 50:375-84. 2005
    ..The TaqMan PCR assay can offer us a complementary and confirmative test...
  53. ncbi request reprint Gelatinolytic activity of matrix metalloproteinase in lung cancer studied using film in situ zymography stamp method
    Masahiro Kaji
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Lung Cancer 39:125-30. 2003
    ..MMP-2 may play an important role in the lymphatic invasion of lung cancer. FIZ stamp method may be a simple and useful diagnostic aid for the presence of cancer cells in the resected specimen...
  54. ncbi request reprint Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors
    Eriko Suzuki
    Department of Surgery II, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Clin Oncol 36:351-6. 2006
    ..Since several reports have shown that invasive thymoma overexpress the EGFR protein, we examined the EGFR expression and mutation statuses in thymoma and thymic carcinoma tissues...
  55. ncbi request reprint PIK3CA mutation status in Japanese lung cancer patients
    Osamu Kawano
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Lung Cancer 54:209-15. 2006
    ..PIK3CA gene mutations were rare in lung cancer; rarer in adenocarcinoma. Further functional analyses of the PIK3CA mutations are warranted to study if they could be the target of therapy for the lung cancer...
  56. ncbi request reprint A correlation between EGFR gene mutation status and bronchioloalveolar carcinoma features in Japanese patients with adenocarcinoma
    Hiroshi Haneda
    Department of Surgery II, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Clin Oncol 36:69-75. 2006
    ..To further investigate the prevalence of EGFR mutations in relation to pathological factors, we evaluated EGFR mutations in series of Japanese adenocarcinoma patients who had never been treated with gefitinib...
  57. ncbi request reprint ErbB3 mRNA expression correlated with specific clinicopathologic features of Japanese lung cancers
    Osamu Kawano
    Department of Sugery, Nagoya City University Medical School, Nagoya, Japan
    J Surg Res 146:43-8. 2008
    ..In this study, we have investigated the erbB3 mRNA levels in reference to clinicopathologic data and EGFR mutation status in Japanese lung cancer specimens...
  58. doi request reprint KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung
    Keisuke Yokota
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Oncol Rep 28:1187-92. 2012
    ..The chimeric oncogene may be a promising molecular target for the personalized diagnosis and treatment of NSCLC...
  59. pmc Characterizing the cancer genome in lung adenocarcinoma
    Barbara A Weir
    Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 450:893-8. 2007
    ..More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered...
  60. doi request reprint Thymic carcinoma: 30 cases at a single institution
    Motoki Yano
    Department of Oncology, Immunology, and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Thorac Oncol 3:265-9. 2008
    ..It constitutes a heterogeneous group of tumors that displays different biologic behavior and prognosis. The clinical prognostic factors and treatment of thymic carcinoma are not yet standardized...
  61. ncbi request reprint Ets-1 gene expression in patients with thymoma
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Jpn J Thorac Cardiovasc Surg 50:503-7. 2002
    ..We hypothesize that Ets-1 mRNA expression could be a predictor of thymoma development and invasion...
  62. ncbi request reprint Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 94:809-13. 2003
    ..The combined use of oligonucleotide microarray, real-time RT-PCR, and ELISA analyses provides a powerful new approach to elucidate the in vivo molecular events surrounding the development and progression of thymoma...
  63. ncbi request reprint Elevated serum pro-MMP2 levels in patients with stage IV thymoma
    Hidefumi Sasaki
    Second Department of Surgery, Nagoya City University Medical School, Japan
    Surg Today 32:482-6. 2002
    ..Using a one-step sandwich enzyme immunoassay, we investigated whether serum pro-MMP2 levels could be predictors of the development and extension of thymoma...
  64. doi request reprint Number of recurrent lesions is a prognostic factor in recurrent thymoma
    Motoki Yano
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Interact Cardiovasc Thorac Surg 13:21-4. 2011
    ..Prognosis in thymoma patients with recurrence was reviewed in the present study. Patients with a small number of recurrent lesions showed better prognosis irrespective of the treatment...
  65. pmc Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers
    Tatsuya Toyama
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    BMC Cancer 8:309. 2008
    ..Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these proteins...
  66. ncbi request reprint Prognostic factors of pathologic stage IB non-small cell lung cancer
    Motoki Yano
    Departments of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Ann Thorac Cardiovasc Surg 17:58-62. 2011
    ..The aim of this study was to determine the prognostic factors of pIB disease...
  67. doi request reprint LKB1 gene alterations in surgically resectable adenocarcinoma of the lung
    Katsuhiro Okuda
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Science, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Surg Today 41:107-10. 2011
    ..3) cause the occurrence of autosomal dominant Peutz-Jeghers syndrome (PJS). Nearly half of the non-small cell lung cancer (NSCLC) cell lines and one-third of lung adenocarcinoma in Caucasian patients have an LKB1 mutation...
  68. doi request reprint Expression of AIRE in thymocytes and peripheral lymphocytes
    Eriko Suzuki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Autoimmunity 41:133-9. 2008
    ..AIRE mRNA was expressed higher in B cells than in T cells. Further study is warranted to define the functional role of the AIRE expressed in the lymphoid cells...
  69. ncbi request reprint Elevated serum epidermal growth factor receptor level in stage IV thymoma
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Surg Today 34:477-9. 2004
    ..7 +/- 10.6 ( P = 0.0433) fm/ml. The serum EGFR levels were similar in the pathological subtypes. These findings suggest that serum EGFR levels may serve as a marker that could be used as a diagnostic indicator of the invasion of thymoma...
  70. ncbi request reprint Preoperative steroid pulse therapy for invasive thymoma: clinical experience and mechanism of action
    Yoshihiro Kobayashi
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Cancer 106:1901-7. 2006
    ..Causes were also sought for a possible underlying mechanism of the effect of steroid on thymoma...
  71. ncbi request reprint Epidermal growth factor receptor gene mutation defines distinct subsets among small adenocarcinomas of the lung
    Hiroshi Haneda
    Department of Surgery II, Nagoya City University Medical School, Japan
    Lung Cancer 52:47-52. 2006
    ..EGFR mutation analysis may help identify patients who will respond to treatment with tyrosine kinase inhibitors, e.g., gefitinib...
  72. ncbi request reprint EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    J Guillermo Paez
    Departments of Medical Oncology and Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 304:1497-500. 2004
    ..These results suggest that EGFR mutations may predict sensitivity to gefitinib...
  73. ncbi request reprint Expression of the antiapoptosis gene, AAC-11, as a prognosis marker in non-small cell lung cancer
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Lung Cancer 34:53-7. 2001
    ..0360). Although the AAC-11 gene was not expressed in a majority of NSCLC tumors, we suggest that AAC-11 may predict poor survival...
  74. ncbi request reprint Expression of Periostin, homologous with an insect cell adhesion molecule, as a prognostic marker in non-small cell lung cancers
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Cancer Res 92:869-73. 2001
    ..There was no relationship between periostin gene expression and gender, N- or T-status. The NSCLC patients with periostin expression had significantly poorer survival than the patients without periostin expression (P = 0.0338)...
  75. ncbi request reprint Factors associated with outcome of segmentectomy for non-small cell lung cancer: long-term follow-up study at a single institution in Japan
    Meinoshin Okumura
    Department of Surgery, National Hospital Organization, Kinki Medical Center for Chest Diseases, 1181 Nagasone Cho, Sakai City, Osaka 591 8555, Japan
    Lung Cancer 58:231-7. 2007
    ..057). We concluded that histological type and tumor size were relevant for determining the indication of an intentional segmentectomy for NSCLC with stage IA disease...
  76. ncbi request reprint Overexpression of Hrad17 gene in non-small cell lung cancers correlated with lymph node metastasis
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Lung Cancer 34:47-52. 2001
    ..Hrad17 protein was highly expressed at the advancing margin of the tumor of lung cancer tissue but not within the normal lung tissue by immunohistochemistry. Thus the expression of Hrad17 might correlate with more advanced NSCLC...
  77. ncbi request reprint [A case of non-small cell lung cancer with EGFR mutation responding to S-1 after a therapy with gefitinib]
    Osamu Kawano
    Department of Oncology, Immunology, Nagoya City University Graduate School of Medical Sciences
    Gan To Kagaku Ryoho 36:675-7. 2009
    ..Chest computed tomographyshowed a partial response. No side effect was observed, and continued internal use of S-1 until January 2007 when it was impossible to continue, and meanwhile, the increase of the tumor was not seen...
  78. ncbi request reprint Expression of the prothymosin-a gene as a prognostic factor in lung cancer
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Surg Today 31:936-8. 2001
    ..PTalpha mRNA overexpression in lung cancer was correlated with a poor prognosis...
  79. ncbi request reprint Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Mizuho ku, Nagoya, Japan hisasaki med nagoya cu ac jp
    Oncol Rep 20:1125-30. 2008
    ..This association was not attributed to patient response to adjuvant chemotherapy. Therefore, the role of FGFR4 polymorphism is a prognostic marker for advanced NSCLC in Japanese patients...
  80. ncbi request reprint Novel chemiluminescence assay for serum periostin levels in women with preeclampsia and in normotensive pregnant women
    Hidefumi Sasaki
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 186:103-8. 2002
    ..It is also homologous with the insect cell adhesion molecule fasciclin I. We determined serum periostin concentrations in women with preeclampsia and in normotensive pregnant women...
  81. ncbi request reprint Decreased peroxisome proliferator-activated receptor gamma gene expression is correlated with poor prognosis in patients with esophageal cancer
    Yukio Terashita
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Jpn J Clin Oncol 32:238-43. 2002
    ..Peroxisome proliferator-activated receptor gamma (PPAR gamma) induces apoptosis by ligand stimulation in various tumor cell lines. In esophageal cancer cell lines, PPAR gamma activation also has suppressed the proliferation...
  82. pmc Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors
    Hongbin Ji
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7817-22. 2006
    ..These findings suggest a therapeutic strategy for cancers harboring the EGFRvIII mutation...
  83. ncbi request reprint Endoscopic thoracic sympathectomy for palmar hyperhidrosis: efficacy of T2 and T3 ganglion resection
    Motoki Yano
    Department of Surgery II, Nagoya City University Graduate School of Medical Science, Japan
    Surgery 138:40-5. 2005
    ..However, the extent of resection has not been determined in terms of efficacy and complications. We compared the efficacy and complications of 2-ganglion and single-ganglion resection in patients with palmar hyperhidrosis...
  84. ncbi request reprint Epidermal growth factor receptor gene mutation and computed tomographic findings in peripheral pulmonary adenocarcinoma
    Motoki Yano
    Department of Surgery II, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya, Japan
    J Thorac Oncol 1:413-6. 2006
    ..A retrospective analysis was conducted to identify the correlation between computed tomographic findings of the nodules and EGFR status...
  85. ncbi request reprint Saber-sheath malacic trachea remodeled and fixed into a normal shape by long-term placement and then removal of gianturco wire stent
    Ichiro Fukai
    The Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
    Ann Thorac Surg 76:597-8. 2003
    ..A review of the literature reveals our case to be the first report of curing saber-sheath malacic trachea without leaving any prostheses or other foreign materials...
  86. ncbi request reprint Endostatin gene transfection using a cationic lipid: advantages of transfection before tumor cell inoculation and repeated transfection
    Motoki Yano
    Department of Surgery II, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Gene Ther 11:354-62. 2004
    ..Compared with controls, endostatin expression reduced migration and invasion by 15%. It is concluded that endostation gene transfection before FSI and repeated transfection thereafter results in significant tumor suppression...
  87. ncbi request reprint Expression of Smac/DIABLO is a novel prognostic marker in lung cancer
    Atsushi Sekimura
    Department of Surgery II, Nagoya City University, Mizuho, Nagoya 467 8601, Japan
    Oncol Rep 11:797-802. 2004
    ..047). These results indicate that Smac expression may play a role in the carcinogenesis, progression, and prognosis of primary lung cancer...
  88. ncbi request reprint SAGE mRNA expression in advanced-stage lung cancers
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Eur J Surg Oncol 29:900-3. 2003
    ..We report the correlation of SAGE and HAGE expression with clinicopathological features in patients with lung cancer who had undergone surgery...
  89. ncbi request reprint Expression of Id2 mRNA in neuroblastoma and normal ganglion
    Y Sato
    Department of Surgery II, Nagoya City University Medical School, Japan
    Eur J Surg Oncol 29:284-7. 2003
    ..It has been suggested that Id2 may be involved in the disturbed regulation of cell cycle by interfering with retinoblastoma protein...
  90. ncbi request reprint Endostatin gene therapy on murine lung metastases model utilizing cationic vector-mediated intravenous gene delivery
    Y Nakashima
    Department of Surgery II, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Gene Ther 10:123-30. 2003
    ..These findings suggested that the endostatin gene therapy, using cationic vector-mediated intravenous gene transfer, might be a feasible strategy for organ-targeted prevention and regulation of possible disseminated cancers...
  91. ncbi request reprint Expression of the cdc25B mRNA correlated with that of N-myc in neuroblastoma
    Y Sato
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Jpn J Clin Oncol 31:428-31. 2001
    ..However, we suggest that cdc25B may play an active role as a target of N-myc in neuroblastoma, although the biological function of cdc25B in neuroblastoma remains to be clarified...
  92. ncbi request reprint [Simultaneously treated thymoma and lung cancer; report of a case]
    M Muro
    Department of Surgery, Fukuyama City Hospital, Fukuyama, Japan
    Kyobu Geka 63:1087-9. 2010
    ..Partial resection of right lung and thymectomy were performed. The mediastinal mass and 2 ground-glass attenuations in the right upper lobe proved to be thymoma and bronchioloalveolar carcinomas, respectively by pathology...
  93. ncbi request reprint Elevated serum vascular endothelial growth factor and basic fibroblast growth factor levels in patients with thymic epithelial neoplasms
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Surg Today 31:1038-40. 2001
    ..Thus, while serum VEGF and bFGF levels may serve as markers for thymic epithelial tumors, it is unlikely that circulating VEGF and bFGF could be used as markers for assessing the progression of thymoma tumors...
  94. ncbi request reprint HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma
    S Bao
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 59:2023-8. 1999
    ....
  95. ncbi request reprint Clinical significance of tissue inhibitor of metalloproteinase and matrix metalloproteinase mRNA expression in thymoma
    H Yukiue
    Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Aichi, Japan
    J Surg Res 109:86-91. 2003
    ..MMPs and TIMPs are considered to play an important role in carcinoma invasion and metastasis. We hypothesized that MMPs and TIMPs also play an important role in thymoma...
  96. ncbi request reprint [Surgery for multiple primary lung cancers]
    Y Yamakawa
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Kyobu Geka 55:10-4. 2002
    ..Their 5 year survival rate was 36%. Especially of the patients with stage I lung cancer, 5 year survival rate was 65%. Radical but less invasive operation like VATS should be chosen for their treatment...
  97. ncbi request reprint [Therapeutic options which potentially cure patients with thymoma]
    I Fukai
    Department of General Thoracic Suegery, Nagoya City University Hospital, Nagoya, Japan
    Kyobu Geka 55:959-64. 2002
    ..The fact led us administer corticosteroid not only in preoperative setting but during postoperative HI. A better prognosis may be anticipated, although the follow up period is short and the number of patients involved is small...
  98. ncbi request reprint Autoantibody to gravin is expressed more strongly in younger and nonthymomatous patients with myasthenia gravis
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Surg Today 31:1036-7. 2001
    ..These findings suggest that antigravin antibody activities could be a useful prognostic factor and that the gravin antibody of MG may have a function which prevents the protein A-kinase binding pathway...