Hideki Ono

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. doi request reprint Reduction in sympathetic nerve activity as a possible mechanism for the hypothermic effect of oseltamivir, an anti-influenza virus drug, in normal mice
    Hideki Ono
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Basic Clin Pharmacol Toxicol 113:25-30. 2013
  2. ncbi request reprint [Cooperation among pharmaceutical, medical and nursing schools aimed at 6-year pharmaceutical education]
    Hideki Ono
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori 3 1, Mizuho ku, Nagoya 467 8603, Japan
    Yakugaku Zasshi 132:21-9. 2012
  3. ncbi request reprint Oseltamivir, an anti-influenza virus drug, produces hypothermia in mice
    Hideki Ono
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Biol Pharm Bull 31:638-42. 2008
  4. ncbi request reprint Neurochemical evidence that supraspinally administered gabapentin activates the descending noradrenergic system after peripheral nerve injury
    Yuichi Takeuchi
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Eur J Pharmacol 556:69-74. 2007
  5. doi request reprint Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury
    Daisuke Kodama
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Pain 152:809-17. 2011
  6. ncbi request reprint Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model
    Yuichi Takeuchi
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya 467 8603, Japan
    Neuropharmacology 53:842-53. 2007
  7. doi request reprint Gabapentin produces PKA-dependent pre-synaptic inhibition of GABAergic synaptic transmission in LC neurons following partial nerve injury in mice
    Keiko Takasu
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Japan
    J Neurochem 105:933-42. 2008
  8. ncbi request reprint The supraspinally mediated analgesic effects of zonisamide in mice after peripheral nerve injury are independent of the descending monoaminergic system
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Pharmacol Sci 104:335-40. 2007
  9. ncbi request reprint Gabapentin depresses C-fiber-evoked field potentials in rat spinal dorsal horn only after induction of long-term potentiation
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Exp Neurol 202:280-6. 2006
  10. doi request reprint Spinal hyperpolarization-activated cyclic nucleotide-gated cation channels at primary afferent terminals contribute to chronic pain
    Keiko Takasu
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Pain 151:87-96. 2010

Collaborators

  • Masahiro Ohsawa
  • Akira Haji
  • Kunitoshi Uchida
  • Kazuya Saitoh
  • Mitsuo Tanabe
  • Motoko Honda
  • Keiko Takasu
  • Shohei Yamamoto
  • Satoko Kimura
  • Daisuke Kodama
  • Yuichi Takeuchi
  • Shinobu Shimizu
  • Soichiro Ohnami
  • Tomoka Nakamura
  • Yurika Kino
  • Akiko Sakaue
  • Yui Iwajima
  • Yukihisa Kurono
  • Yuko Nagano
  • Yasuhiro Maeda
  • Yuka Niwa
  • Yoshiaki Ohi
  • Akira Kato
  • Shunji Shinohara
  • Yu Kinoshita
  • Sen Ichi Oda
  • Keiko Imaida
  • Jun Ichiro Oka
  • Takashi Nishida
  • Naoko Sato
  • Yuko Sekiguchi

Detail Information

Publications46

  1. doi request reprint Reduction in sympathetic nerve activity as a possible mechanism for the hypothermic effect of oseltamivir, an anti-influenza virus drug, in normal mice
    Hideki Ono
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Basic Clin Pharmacol Toxicol 113:25-30. 2013
    ..These results suggest that oseltamivir (i.p.) causes hypothermia through depression of sympathetic temperature regulatory mechanisms via inhibition of nicotinic receptor function and through unknown central mechanisms...
  2. ncbi request reprint [Cooperation among pharmaceutical, medical and nursing schools aimed at 6-year pharmaceutical education]
    Hideki Ono
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori 3 1, Mizuho ku, Nagoya 467 8603, Japan
    Yakugaku Zasshi 132:21-9. 2012
    ....
  3. ncbi request reprint Oseltamivir, an anti-influenza virus drug, produces hypothermia in mice
    Hideki Ono
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Biol Pharm Bull 31:638-42. 2008
    ....
  4. ncbi request reprint Neurochemical evidence that supraspinally administered gabapentin activates the descending noradrenergic system after peripheral nerve injury
    Yuichi Takeuchi
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Eur J Pharmacol 556:69-74. 2007
    ..Thus, the supraspinally mediated analgesic effects of gabapentin are correlated with an increase in spinal noradrenaline turnover...
  5. doi request reprint Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury
    Daisuke Kodama
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Pain 152:809-17. 2011
    ..Chronic pain crucially influences hippocampal plasticity related to cognitive function. Increasing the extracellular level of glycine via blockade of GlyT1 is a potential therapeutic approach for chronic pain with memory impairment...
  6. ncbi request reprint Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model
    Yuichi Takeuchi
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya 467 8603, Japan
    Neuropharmacology 53:842-53. 2007
    ..Together, these results indicate that pregabalin supraspinally activates the descending noradrenergic pain inhibitory system coupled with spinal alpha(2)-adrenoceptors to ameliorate neuropathic pain...
  7. doi request reprint Gabapentin produces PKA-dependent pre-synaptic inhibition of GABAergic synaptic transmission in LC neurons following partial nerve injury in mice
    Keiko Takasu
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Japan
    J Neurochem 105:933-42. 2008
    ..These findings provide crucial evidence of how supraspinally acting gabapentin recruits the descending noradrenergic system...
  8. ncbi request reprint The supraspinally mediated analgesic effects of zonisamide in mice after peripheral nerve injury are independent of the descending monoaminergic system
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Pharmacol Sci 104:335-40. 2007
    ..Thus, it appears that the supraspinally mediated analgesic effects of zonisamide are independent of the descending monoaminergic pain inhibitory system...
  9. ncbi request reprint Gabapentin depresses C-fiber-evoked field potentials in rat spinal dorsal horn only after induction of long-term potentiation
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Exp Neurol 202:280-6. 2006
    ....
  10. doi request reprint Spinal hyperpolarization-activated cyclic nucleotide-gated cation channels at primary afferent terminals contribute to chronic pain
    Keiko Takasu
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Pain 151:87-96. 2010
    ..The present behavioral and electrophysiological data suggest that spinal HCN channels, most likely at the primary afferent terminals, contribute to the maintenance of chronic pain...
  11. ncbi request reprint Protein kinase A-dependence of the supraspinally mediated analgesic effects of gabapentin on thermal and mechanical hypersensitivity
    Keiko Takasu
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Pharmacol Sci 110:223-6. 2009
    ....
  12. doi request reprint Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Neurosci Res 86:3258-64. 2008
    ....
  13. ncbi request reprint Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes
    Yurika Kino
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Pharmacol Sci 99:52-60. 2005
    ..Thus, supraspinal I receptors (most likely I3) and descending monoaminergic influences are necessary for tizanidine-induced inhibition of spinal segmental reflexes...
  14. doi request reprint Gabapentin and pregabalin ameliorate mechanical hypersensitivity after spinal cord injury in mice
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Eur J Pharmacol 609:65-8. 2009
    ..These results suggest that gabapentin and pregabalin could be useful therapeutic tools for patients with neuropathic pain after spinal cord injury...
  15. ncbi request reprint Antinociceptive effects of sodium channel-blocking agents on acute pain in mice
    Akiko Sakaue
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Pharmacol Sci 95:181-8. 2004
    ..Our results show that sodium channel blocking agents have a preferential antinociceptive action against thermal stimulation that is likely to be attributed to their local anesthetic action...
  16. ncbi request reprint Neuroprotection via strychnine-sensitive glycine receptors during post-ischemic recovery of excitatory synaptic transmission in the hippocampus
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Pharmacol Sci 113:378-86. 2010
    ..However, GlyT1 inhibition is unlikely to elicit a sufficient increase in the extracellular level of glycine to generate neuroprotection...
  17. ncbi request reprint Glycine transporter blockade ameliorates motor ataxia in a mouse model of spinocerebellar atrophy
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    J Pharmacol Sci 109:444-8. 2009
    ..These results suggest the therapeutic relevance of GlyT1 inhibitors for amelioration of motor ataxia in spinocerebellar atrophy by increasing the endogenous concentration of glycine near the glycine-recognition site of the NMDA receptor...
  18. doi request reprint Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Japan
    Anesthesiology 108:929-37. 2008
    ....
  19. ncbi request reprint Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors
    Motoko Honda
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Neuropharmacology 51:866-72. 2006
    ..These results indicate that fluvoxamine exerts its antiallodynic effects on neuropathic pain via descending 5-HT fibers and spinal 5-HT2A or 5-HT2C receptors, and the antinociception on acute mechanical pain via 5-HT3 receptors...
  20. ncbi request reprint N- and L-type voltage-dependent Ca2+ channels contribute to the generation of after-discharges in the spinal ventral root after cessation of noxious mechanical stimulation
    Shohei Yamamoto
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Japan
    J Pharmacol Sci 119:82-90. 2012
    ..These findings suggested that N- and L-type VDCCs in the dorsal horn were involved in the generation of after-discharges and these blockers might be useful for treatment of persistent pain that involves the spinal pathway...
  21. ncbi request reprint Endogenous GABA does not mediate the inhibitory effects of gabapentin on spinal reflexes in rats
    Shinobu Shimizu
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    J Pharmacol Sci 94:137-43. 2004
    ..The dorsal root reflex potentials were not affected by gabapentin. These results suggest that endogenous GABA does not mediate the inhibitory effects of gabapentin on spinal reflexes...
  22. ncbi request reprint Contribution of TRPV1 receptor-expressing fibers to spinal ventral root after-discharges and mechanical hyperalgesia in a spared nerve injury (SNI) rat model
    Shohei Yamamoto
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    J Pharmacol Sci 121:9-16. 2013
    ..It is suggested that the mechanisms responsible for generating mechanical allodynia differ from those for prolongation of mechanical hyperalgesia...
  23. doi request reprint High doses of oseltamivir phosphate induce acute respiratory arrest in anaesthetized rats
    Satoko Kimura
    Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    Basic Clin Pharmacol Toxicol 111:232-9. 2012
    ..We demonstrated that OP causes central suppression of the respiratory function in rats and suggest a relationship between the OP-induced cardiorespiratory arrest and sudden death observed in influenza patients after taking OP...
  24. ncbi request reprint Altered hippocampal long-term potentiation after peripheral nerve injury in mice
    Daisuke Kodama
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Eur J Pharmacol 574:127-32. 2007
    ..These results suggest that beta-adrenergic functions are changed in chronic pain conditions, which may underlie the deficiency of long-term potentiation...
  25. doi request reprint Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Neuropharmacology 56:702-8. 2009
    ....
  26. doi request reprint Role of voltage-dependent calcium channel subtypes in spinal long-term potentiation of C-fiber-evoked field potentials
    Soichiro Ohnami
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya 467 8603, Japan
    Pain 152:623-31. 2011
    ..In vivo electrophysiological studies demonstrate the distinct and predominant functions of voltage-dependent calcium channel subtypes for spinal long-term potentiation and chronic pain...
  27. ncbi request reprint Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Pharmacol Sci 107:213-20. 2008
    ..c. or 10 and 30 mug, i.t.) reversed the mechanical hyperexcitability. Our results suggest that zonisamide can be a useful therapeutic agent, presumably for both prevention and reversal of pathophysiologic pain...
  28. doi request reprint Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Eur J Pharmacol 589:102-5. 2008
    ....
  29. ncbi request reprint GABAB receptors do not mediate the inhibitory actions of gabapentin on the spinal reflex in rats
    Shinobu Shimizu
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    J Pharmacol Sci 96:444-9. 2004
    ..v.) but not by gabapentin (i.v.). Thus, GABAB receptors do not appear to contribute to the gabapentin-induced inhibition of the spinal reflex...
  30. ncbi request reprint Spinal cord injury-specific depression of monosynaptic spinal reflex transmission by l-5-hydroxytryptophan results from loss of the 5-HT uptake system and not 5-HT receptor supersensitivity
    Motoko Honda
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Exp Neurol 202:258-61. 2006
    ....
  31. ncbi request reprint Functional alteration of inhibitory influences on spinal motor output in painful diabetic neuropathy in rats
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Neurosci Lett 389:152-6. 2005
    ..Thus, in diabetic painful neuropathy, reduced spinal intrinsic inhibition in the ventral horn contributes to an enhanced spinal segmental motor output...
  32. ncbi request reprint Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors
    Motoko Honda
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, 467 8603, Nagoya, Japan
    Eur J Pharmacol 458:91-9. 2003
    ....
  33. ncbi request reprint Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT1B receptors
    Motoko Honda
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho, Nagoya 467 8603, Japan
    Eur J Pharmacol 482:155-61. 2003
    ..These results suggest that serotonergic depression of monosynaptic reflex transmission is mediated by 5-HT(1B) receptors...
  34. ncbi request reprint Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors
    Motoko Honda
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Eur J Pharmacol 503:55-61. 2004
    ..These results suggest that 5-HT released from serotonergic terminals depresses monosynaptic reflex transmission via 5-HT1D receptors...
  35. pmc Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Br J Pharmacol 144:703-14. 2005
    ..6. It was concluded that the antihyperalgesic and antiallodynic effects of gabapentin are mediated substantially by the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors...
  36. ncbi request reprint Enhanced wind-up of the C-fiber-mediated nociceptive flexor reflex movement following painful diabetic neuropathy in mice
    Satoko Kimura
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    J Pharmacol Sci 97:195-202. 2005
    ..Such changes in the excitability of spinal neurons in diabetic mice may represent some aspect of painful diabetic neuropathy...
  37. ncbi request reprint Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, 467 8603, Japan
    Naunyn Schmiedebergs Arch Pharmacol 372:107-14. 2005
    ..Together, following peripheral nerve injury, it appears that zonisamide produces centrally mediated antihyperalgesic and antiallodynic effects partly via the blockade of nitric oxide synthesis...
  38. ncbi request reprint Presynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    J Neurosci 26:1795-802. 2006
    ..These results suggest that IPSC inhibition via presynaptic I1-imidazoline receptors involves intracellular adenylate cyclase activity and is influenced by static PKC activity in the striatum...
  39. ncbi request reprint Phenytoin and carbamazepine delay the initial depression of the population spike upon exposure to in vitro ischemia and promote its post-ischemic functional recovery in rat hippocampal slices
    Mitsuo Tanabe
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Eur J Pharmacol 553:104-8. 2006
    ..These results suggest that treatment with phenytoin and carbamazepine increases the resistance of tissue to energy deprivation, as evidenced by the facilitated post-ischemic recovery of the PS, despite prolonged ischemia...
  40. ncbi request reprint Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine
    Motoko Honda
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Japan
    Eur J Pharmacol 445:187-93. 2002
    ....
  41. ncbi request reprint Taltirelin improves motor ataxia independently of monoamine levels in rolling mouse nagoya, a model of spinocerebellar atrophy
    Tomoka Nakamura
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 28:2244-7. 2005
    ....
  42. ncbi request reprint Noxious stimuli evoke a biphasic flexor reflex composed of A delta-fiber-mediated short-latency and C-fiber-mediated long-latency withdrawal movements in mice
    Satoko Kimura
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    J Pharmacol Sci 95:94-100. 2004
    ..This method will be useful for understanding how Adelta-fiber- and C-fiber-mediated nociceptive reflexes are affected by drugs in the whole animal system...
  43. ncbi request reprint [Contribution of the sensitization of supraspinal nociceptive transmission in chronic pain]
    Masahiro Ohsawa
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
    Yakugaku Zasshi 134:387-95. 2014
    ..In this review, we would like to discuss the possible involvement of the supraspinal sensitization in neuropathic pain and in its application for the curative treatment in chronic pain...
  44. pmc Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury
    Keiko Takasu
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Br J Pharmacol 148:233-44. 2006
    ..In contrast, the effect of supraspinal gabapentin on thermal hypersensitivity is independent of the spinal cholinergic-NO system...
  45. doi request reprint Carnosine has antinociceptive properties in the inflammation-induced nociceptive response in mice
    Masahiro Ohsawa
    Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714 1 Yoshino machi, Nobeoka shi, Miyazaki 882 8508 Japan
    Eur J Pharmacol 682:56-61. 2012
    ..Our immunohistochemical and behavioral data suggest that carnosine has antinociceptive effects toward inflammatory pain, which may be mediated by the attenuation of nociceptive sensitization in the spinal cord...
  46. ncbi request reprint Spinal ventral root after-discharges as a pain index: involvement of NK-1 and NMDA receptors
    Shohei Yamamoto
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya 467 8603, Japan
    Brain Res 1082:115-23. 2006
    ..There results suggest that simultaneous recordings of during- and after-discharges are useful to study pain mechanisms and analgesics as well as to discriminate the analgesic effects from the side effects such as muscle relaxant effects...