A Okumura

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia
    Yasutaka Murata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Brain Dev 27:17-21. 2005
  2. ncbi request reprint Non-epileptic pedaling-like movement induced by triclofos
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 26:487-9. 2004
  3. ncbi request reprint The timing of brain insults in preterm infants who later developed West syndrome
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuropediatrics 32:245-9. 2001
  4. ncbi request reprint A pilot study on umbilical venous level of natriuretic peptides in preterm infants and their relation to periventricular leukomalacia and antenatal complications
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 24:30-2. 2002
  5. pmc Guillain-Barré syndrome associated with central nervous system lesions
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan Department of Pediatrics, Kamo Hospital, Japan
    Arch Dis Child 86:304-6. 2002
  6. ncbi request reprint Brain malformation of the surviving twin of intrauterine co-twin demise
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    J Child Neurol 22:85-8. 2007
  7. ncbi request reprint Developmental outcome and types of chronic-stage EEG abnormalities in preterm infants
    Akihisa Okumura
    Department of Peadiatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Dev Med Child Neurol 44:729-34. 2002
  8. ncbi request reprint The mildest form of acute necrotizing encephalopathy associated with influenza A
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuropediatrics 37:261-3. 2006
  9. ncbi request reprint Popliteal angle in infants with west syndrome
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Child Neurol 21:898-900. 2006
  10. ncbi request reprint Parry-Romberg syndrome with a clinically silent white matter lesion
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    AJNR Am J Neuroradiol 27:1729-31. 2006

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia
    Yasutaka Murata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Brain Dev 27:17-21. 2005
    ..These findings support a growing consensus that cPVL is often the result of maternal and fetal factors as well as antenatal treatment...
  2. ncbi request reprint Non-epileptic pedaling-like movement induced by triclofos
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 26:487-9. 2004
    ..The pedaling-like movement lasted for about 2 h intermittently. Electroencephalography during this movement revealed physiological activities with semirhythmic theta waves without paroxysmal activities...
  3. ncbi request reprint The timing of brain insults in preterm infants who later developed West syndrome
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuropediatrics 32:245-9. 2001
    ..The timing of brain injury of preterm infants who later developed West syndrome is more often prenatal than generally considered...
  4. ncbi request reprint A pilot study on umbilical venous level of natriuretic peptides in preterm infants and their relation to periventricular leukomalacia and antenatal complications
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 24:30-2. 2002
    ..Umbilical venous levels of natriuretic peptides were not useful to predict neurological outcome in preterm infants...
  5. pmc Guillain-Barré syndrome associated with central nervous system lesions
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan Department of Pediatrics, Kamo Hospital, Japan
    Arch Dis Child 86:304-6. 2002
    ..Her symptoms resolved within two months. Subsequent magnetic resonance imaging revealed cavity formation in the deep white matter and atrophic changes in the right occipital lobes...
  6. ncbi request reprint Brain malformation of the surviving twin of intrauterine co-twin demise
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    J Child Neurol 22:85-8. 2007
    ..Seizures were observed weekly despite treatment with carbamazepine. The malformation of our patient was considered to be a result of a mixture of destructive process and disorders of neuronal proliferation and migration...
  7. ncbi request reprint Developmental outcome and types of chronic-stage EEG abnormalities in preterm infants
    Akihisa Okumura
    Department of Peadiatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Dev Med Child Neurol 44:729-34. 2002
    ..Results indicate that types of chronic-stage EEG abnormalities are related to types of neurological sequelae and are useful for assessing the mode of brain injury in preterm infants...
  8. ncbi request reprint The mildest form of acute necrotizing encephalopathy associated with influenza A
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuropediatrics 37:261-3. 2006
    ..Diffusion-weighted imaging showed mildly high signal intensities in the bilateral thalami, deep white matter in the centrum semiovale, and frontal lobes. Conventional T (1)- or T (2)-weighted images revealed no abnormalities...
  9. ncbi request reprint Popliteal angle in infants with west syndrome
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Child Neurol 21:898-900. 2006
    ..These results suggest that a tight popliteal angle might be an indicator of poor neurologic outcome in patients with West syndrome...
  10. ncbi request reprint Parry-Romberg syndrome with a clinically silent white matter lesion
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    AJNR Am J Neuroradiol 27:1729-31. 2006
    ..Pyramidal tracts and optic radiations were preserved on diffusion tensor tractography. We will correlate these neuroimaging findings with normal psychomotor development in our patient...
  11. ncbi request reprint Transient encephalopathy with reversible white matter lesions in children
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuropediatrics 37:159-62. 2006
    ..These abnormalities disappeared along with the neurological symptoms within a week in both patients. These children represent a characteristic group of patients among childhood acute encephalopathy...
  12. ncbi request reprint Amplitude spectral analysis of maturational changes of delta waves in preterm infants
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 25:406-10. 2003
    ..In conclusion, maturational EEG changes assessed by amplitude spectral analysis were prominent in the occipital areas, and in the frequency less than 1Hz...
  13. ncbi request reprint Benign partial epilepsy in infancy long-term outcome and marginal syndromes
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Epilepsy Res 70:S168-73. 2006
    ..Another three patients had experienced seizures with mild gastroenteritis. The seizure outcome of three patients with mild cognitive problems was quite excellent. These patients can be grouped as a marginal syndrome of BPEI...
  14. ncbi request reprint Antiepileptic treatment against clustered seizures in benign partial epilepsy in infancy
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, and Department of Pediatrics, Okazaki City Hospital, Japan
    Brain Dev 28:582-5. 2006
    ..In conclusion, the efficacy of diazepam/bromazepam or phenobarbital was insufficient for the cessation of clustered seizures in benign partial epilepsy in infancy...
  15. ncbi request reprint Antipyretics and delirious behavior during febrile illness
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Pediatr Int 48:40-3. 2006
    ..The purpose of the present paper was to study the use of antipyretics in children with delirium associated with fever in order to clarify their possible adverse effects...
  16. ncbi request reprint Single photon emission computed tomography and serial MRI in preterm infants with kernicterus
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 28:348-52. 2006
    ..Single photon emission computed tomography will be useful for the diagnosis of kernicterus, whereas MRI abnormalities become less clear beyond infancy...
  17. ncbi request reprint Delirious behavior in children with influenza: its clinical features and EEG findings
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 27:271-4. 2005
    ..EEG revealed transient and mild abnormalities in children with delirious behavior but without encephalitis/encephalopathy, and thus might be useful for diagnostic evaluation in such condition...
  18. ncbi request reprint Treatment and outcome in patients with febrile convulsion associated with epileptiform discharges on electroencephalography
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 26:241-4. 2004
    ..Intermittent or daily anticonvulsant therapy will not reduce the risk of recurrence of FCs or later development of unevoked seizures in patients with FC with epileptiform discharges...
  19. ncbi request reprint A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 26:525-9. 2004
    ..2-0.5 microg/ml). In the other patients, the serum LD levels were below the lower limit of measurement. Adverse effects of LDT were not observed in any patients. LDT therapy was safe and effective in patients with CwG...
  20. ncbi request reprint Physical condition of preterm infants with periventricular leukomalacia
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain Dev 23:805-9. 2001
    ..01) groups. On the other hand, the residual score (SNAP minus lung score) was not significantly different among the three groups. The physical condition of infants with PVL was not poor, although respiratory distress was often observed...
  21. ncbi request reprint Clinico-electrical evolution in pre-hypsarrhythmic stage: towards prediction and prevention of West syndrome
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Brain Dev 23:482-7. 2001
    ..Multifocal spikes were very likely to be observed during early infancy, but hypsarrhythmia was observed immediately after their appearance. It is not always easy to select patients for prevention of WS with sufficient treatment period...
  22. ncbi request reprint Epilepsies after Pocket Monster seizures
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Epilepsia 46:980-2. 2005
    ..We conducted a 5-year follow-up study in patients with a seizure induced by animated cartoon "Pocket Monster."..
  23. ncbi request reprint Hypocarbia in preterm infants with periventricular leukomalacia: the relation between hypocarbia and mechanical ventilation
    A Okumura
    Department of Pediatrics, Nagoya University, School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Pediatrics 107:469-75. 2001
    ..The aim of this study was to elucidate the relationship between mechanical ventilation and hypocarbia in infants with periventricular leukomalacia (PVL)...
  24. ncbi request reprint The clinical characterizations of benign partial epilepsy in infancy
    A Okumura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Neuropediatrics 37:359-63. 2006
    ..The main features of benign partial epilepsy in infancy were a high incidence of a cluster of seizures, short persistence of seizures, and normal initial interictal EEGs...
  25. doi request reprint Differences of clinical manifestations according to the patterns of brain lesions in acute encephalopathy with reduced diffusion in the bilateral hemispheres
    A Okumura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    AJNR Am J Neuroradiol 30:825-30. 2009
    ..We compared clinical, laboratory, and neuroimaging findings according to the patterns of brain lesions among children with reduced diffusion in the bilateral hemispheres...
  26. ncbi request reprint Relation between the date of cyst formation observable on ultrasonography and the timing of injury determined by serial electroencephalography in preterm infants with periventricular leukomalacia
    T Kubota
    Department of Pediatrics, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan
    Brain Dev 23:390-4. 2001
    ....
  27. doi request reprint Transient and mild reduction of consciousness during febrile illness in children
    T Kato
    Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan
    Neuropediatrics 42:183-7. 2011
    ..In conclusion, we consider that transient and mild reduction of consciousness during febrile illness is a unique clinical group that is constituted by children both with and without delirious behavior...
  28. ncbi request reprint Five-year follow-up of patients with partial epilepsies in infancy
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Neurol 24:290-6. 2001
    ..87. The seizure and developmental outcomes were better in this study than those in previous studies. The combination of the four factors will be useful for predicting the outcomes in patients with partial epilepsies in infancy...
  29. ncbi request reprint A pilot study on benign partial epilepsy in children with complex partial seizures
    Y Ishiguro
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Seizure 10:194-6. 2001
    ..The authors suggest that a benign form of CPS in children can be recognised...
  30. ncbi request reprint Determination of timing of brain injury in preterm infants with periventricular leukomalacia with serial neonatal electroencephalography
    F Hayakawa
    Department of Pediatrics, Okazaki City Hospital, Okazaki, Aichi, Japan
    Pediatrics 104:1077-81. 1999
    ..The aim of this study was to determine the timing of brain injury in infants with periventricular leukomalacia (PVL) with serial electroencephalography (EEG) recordings during the neonatal period...
  31. ncbi request reprint [Convulsion associated with mild gastroenteritis: occurrence in identical twins on the same day]
    A Okumura
    Department of Pediatrics, Anjo Kosei Hospital, Aichi
    No To Hattatsu 31:59-62. 1999
    ..During the follow-up period, no recurrence of seizures was observed and psychomotor development was normal in both of them...
  32. ncbi request reprint Electroencephalographic aspects of periventricular hemorrhagic infarction in preterm infants
    T Kato
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuropediatrics 35:161-6. 2004
    ..75 and 1.0, respectively. Acute and chronic stage EEG abnormalities give valuable information for short-term and long-term outcome in preterm infants with PVHI...
  33. ncbi request reprint Prognostic value of EEG depression in preterm infants for later development of cerebral palsy
    K Maruyama
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuropediatrics 33:133-7. 2002
    ..But sensitivity was markedly decreased after day 3, and positive predictive value was highest on day 2. An EEG on day 1 or 2 will be useful in order to predict developmental outcome of preterm infants on the basis of the grade of ASA...
  34. doi request reprint Electroencephalogram and flash visual evoked potentials for detecting periventricular leukomalacia
    H Kidokoro
    Department of Pediatrics, Anjo Kosei Hospital, Aichi, Japan
    Neuropediatrics 39:226-32. 2008
    ..The aim of this study was to evaluate the usefulness of a combination of electroencephalogram (EEG) and flash visual evoked potentials (FVEPs) for predicting periventricular leukomalacia (PVL) in the early days of life...
  35. doi request reprint Diffusion-weighted magnetic resonance imaging in infants with periventricular leukomalacia
    H Kidokoro
    Department of Pediatrics, Anjo Kosei Hospital, Aichi, Japan
    Neuropediatrics 39:233-8. 2008
    ....
  36. ncbi request reprint Ictal EEG in patients with convulsions with mild gastroenteritis
    Koichi Maruyama
    Department of Pediatrics, Anjo Kosei Hospital, 28 Higashi Hirokute, Anjo cho, Anjo, Aichi 446 8602, Japan
    Brain Dev 29:43-6. 2007
    ..The seizure of patients with CwG is likely to be a partial seizure with secondary generalization...
  37. ncbi request reprint Delayed neurological signs following isolated parasagittal injury in asphyxia at term
    Yoshiaki Sato
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Paediatr Neurol 12:359-65. 2008
    ....
  38. doi request reprint Absent cyclicity on aEEG within the first 24 h is associated with brain damage in preterm infants
    H Kidokoro
    Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan
    Neuropediatrics 41:241-5. 2010
    ..Our aim was to clarify the relationship between amplitude-integrated electroencephalographic (aEEG) findings before 24 h of age in preterm infants and neurodevelopmental outcome...
  39. ncbi request reprint [The prognostic value of neonatal cranial ultrasonography in infants with periventricular leukomalacia]
    F Hayakawa
    Department of Pediatrics, Anjo Kosei Hospital, Aichi
    No To Hattatsu 26:313-7. 1994
    ..The degree of periventricular echo-lesion was associated with that of neurological abnormalities of infants. The extent of periventricular echo-lesion has the same prognostic value as findings on MRI in infants with PVL...
  40. doi request reprint Focal epilepsy resulting from a de novo SCN1A mutation
    A Okumura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Neuropediatrics 38:253-6. 2007
    ..Genetic analysis showed a heterozygous missense mutation (c.5311A>T: I1771F) in the patient, which was not detected in her parents...
  41. ncbi request reprint [A case of pachygyria with cystic changes in the periventricular white matter and putamen]
    A Okumura
    Department of Pediatrics, Anjo Kosei Hospital, Aichi
    No To Hattatsu 28:424-9. 1996
    ..We considered that these secondary lesions were due to frequent seizures which could cause insufficient supply of blood and glucose in those areas...
  42. ncbi request reprint Quantitative evaluation of thalami and basal ganglia in infants with periventricular leukomalacia
    Y Lin
    Department of Paediatrics, Nagoya University School of Medicine, Aichi, Japan
    Dev Med Child Neurol 43:481-5. 2001
    ..Results of our study suggest that the volume of the thalami is reduced and that thalamic involvement is present in infants with white matter lesions who have moderate to severe PVL...
  43. ncbi request reprint The predictive value of electroencephalogram during early infancy for later development of West syndrome in infants with cystic periventricular leukomalacia
    Motomasa Suzuki
    Department of Pediatrics, Okazaki City Hospital, Aichi, Japan
    Epilepsia 44:443-6. 2003
    ..The aim of this study was to elucidate a predictive value of electroencephalogram (EEG) during early infancy for later development of West syndrome (WS) in premature infants with cystic periventricular leukomalacia (PVL)...
  44. ncbi request reprint Popliteal angle in preterm infants with periventricular leukomalacia
    Toru Kato
    Department of Pediatrics, Anjo Kosei Hospital, Anjo, Aichi, Japan
    Pediatr Neurol 32:84-6. 2005
    ..The results of this study suggest that evaluation of popliteal angle is useful for detection of infants with periventricular leukomalacia, although false-negative rate is high during late infancy...
  45. ncbi request reprint [Perinatal brain injury in infants with depressed EEG activities immediately after birth]
    F Hayakawa
    Department of Pediatrics, Anjo Kosei Hospital, Aichi
    No To Hattatsu 28:48-52. 1996
    ..Periventricular leukomalacia rather correlated with moderate depression of EEG activities than severe depression like observed in full-term neonates who have brain lesions due to perinatal asphyxia...
  46. ncbi request reprint Benign partial epilepsies in infancy
    K Watanabe
    Department of Pediatrics, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, 466, Nagoya, Japan
    Brain Dev 22:296-300. 2000
    ..Some are familial and many of them seem to show an autosomal dominant pattern, but some seem to have autosomal recessive inheritance...
  47. ncbi request reprint Abnormal brushes in preterm infants with periventricular leukomalacia
    H Kidokoro
    Department of Pediatrics, Kasugai Municipal Hospital, Kasugai, Aichi, Japan
    Neuropediatrics 37:265-8. 2006
    ..The aim of this study is to describe a new objective method of detecting white matter injury by use of refiltering function of digital EEG...
  48. ncbi request reprint [A case of congenital plasminogen abnormality with recurrent cerebrovascular ischemic attacks]
    T Kato
    Department of Pediatrics, Anjo Kosei Hospital, Aichi
    No To Hattatsu 31:531-4. 1999
    ..DNA analysis revealed that he was heterozygotic for abnormal plasminogen. Thus, congenital plasminogen abnormality was suspected to be a cause of recurrent cerebrovascular ischemic attacks in this case...
  49. ncbi request reprint Neonatal EEG: a powerful tool in the assessment of brain damage in preterm infants
    K Watanabe
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Brain Dev 21:361-72. 1999
    ..PVL without apparent causes was often associated with abnormal fetal heart rate patterns and early neonatal EEG abnormalities, and considered to have originated in the antepartum period...
  50. doi request reprint Usefulness of single-channel amplitude-integrated electroencephalography for continuous seizure monitoring in infancy: a case report
    Akihisa Okumura
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Brain Dev 31:766-70. 2009
    ..The efficacy of antiepileptic drugs could also be objectively assessed from aEEG findings. Our results show that aEEG is useful for the continuous monitoring of seizures even in older children...
  51. doi request reprint Subacute encephalopathy: clinical features, laboratory data, neuroimaging, and outcomes
    Akihisa Okumura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Neurol 38:111-7. 2008
    ..Recognition of this type of acute encephalopathy is important, and a method to promote early diagnosis is desirable...
  52. ncbi request reprint Popliteal angle of low birth weight infants during the first year of life
    Toru Kato
    Department of Pediatrics, Okazaki City Hospital, Okazaki, Aichi, Japan
    Pediatr Neurol 30:244-6. 2004
    ..One should carefully interpret a tight popliteal angle in low birth weight infants during early infancy. Serial assessment of the popliteal angle is necessary before judging that a low birth weight infant has spastic cerebral palsy...
  53. doi request reprint SCN1B is not related to benign partial epilepsy in infancy or convulsions with gastroenteritis
    S Yamashita
    Department of Pediatrics, Juntendo Nerima Hospital, Tokyo, Japan
    Neuropediatrics 42:135-7. 2011
    ..Our study demonstrated that SCN1B may not be related to the occurrence of BPEI or CwG...
  54. ncbi request reprint Epilepsies of neonatal onset: seizure type and evolution
    K Watanabe
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Dev Med Child Neurol 41:318-22. 1999
    ..In seven of these 15 patients, West syndrome was followed by localization-related epilepsy. Symptomatic localization-related epilepsy with transient West syndrome in infancy is another type of age-dependent epileptic syndrome...
  55. ncbi request reprint Symptomatology of infantile spasms
    K Watanabe
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Brain Dev 23:453-66. 2001
    ..Although clinical spasms are usually symmetric, ictal fast waves are always localized, and the following slow waves are not bilaterally synchronous and generalized, suggesting a focal cortical origin of spasms...
  56. ncbi request reprint [Oligohidrosis caused by zonisamide]
    A Okumura
    Department of Pediatrics, Anjo Kosei Hospital, Aichi
    No To Hattatsu 28:44-7. 1996
    ..On two patients poor sweat responses to heat loading and Ach loading recovered after discontinuation of ZNS. These results suggest that ZNS causes dysfunction of sweat glands...
  57. ncbi request reprint Inflammatory pathological changes in a 2-year-old boy with Charcot-Marie-Tooth disease
    Y Nakai
    Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Japan
    Brain Dev 23:258-60. 2001
    ..It is probable that edema, active demyelination and a few onion bulb formations, which were recognized in this patient, are characteristic early histological changes of HMSN rather than those of corticosteroid-responsive HMSN...
  58. pmc Background electroencephalographic (EEG) activities of very preterm infants born at less than 27 weeks gestation: a study on the degree of continuity
    M Hayakawa
    Department of Pediatric Cardiology and Neonatology, Ogaki Municipal Hospital, Ogaki, Gifu Pref, Japan
    Arch Dis Child Fetal Neonatal Ed 84:F163-7. 2001
    ....
  59. ncbi request reprint Varicella exposure in a neonatal medical centre: successful prophylaxis with oral acyclovir
    M Hayakawa
    Department of Pediatric Cardiology and Neonatology, Ogaki Municipal Hospital, Ogaki, Japan
    J Hosp Infect 54:212-5. 2003
    ....
  60. ncbi request reprint A follow-up survey on seizures induced by animated cartoon TV program "Pocket Monster"
    Yoshiko Ishiguro
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Epilepsia 45:377-83. 2004
    ..To identify the short-term outcome of patients who had seizures while watching an animated cartoon TV program, "Pocket Monster," on December 16, 1997...
  61. ncbi request reprint Nutritional state and growth and functional maturation of the brain in extremely low birth weight infants
    Masahiro Hayakawa
    Department of Pediatric Cardiology and Neonatology, Ogaki Municipal Hospital, Nagoya, Japan
    Pediatrics 111:991-5. 2003
    ..Therefore, we hypothesized that the postnatal nutritional status influenced electrophysiologic maturation in extremely low birth weight infants (ELBWIs)...
  62. ncbi request reprint Hypoxic ischemic encephalopathy associated with neonatal seizures without other neurological abnormalities
    Yoshiaki Sato
    Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan
    Brain Dev 25:215-9. 2003
    ..Our infants suggest that neonatal seizures can also occur in infants with hypoxic ischemic encephalopathy without apparent neurological abnormalities...
  63. ncbi request reprint Clinical features of benign convulsions with mild gastroenteritis
    Naoko Uemura
    Department of Pediatrics, Mitsubishi Nagoya Hospital, 7 8 Sotodoi cho, Atsuta ku, Nagoya, Japan
    Brain Dev 24:745-9. 2002
    ..CwG is characterized by a cluster of seizures that are sometimes induced by pain and/or crying. The seizures are rather refractory to antiepileptic treatment, although the seizure and development outcomes are good...
  64. doi request reprint Kernicterus in preterm infants
    Akihisa Okumura
    Department of Pediatrics, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Pediatrics 123:e1052-8. 2009
    ..We sought to clarify the features of kernicterus in preterm infants...
  65. ncbi request reprint Combination of neonatal electroencephalography and ultrasonography: sensitive means of early diagnosis of periventricular leukomalacia
    Tetsuo Kubota
    Department of Pediatrics, Nagoya University School of Medicine, 65 Tsurumani cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 24:698-702. 2002
    ..Appropriate use of these measurements will make an early diagnosis of infants with PVL possible, even in non-cystic cases...
  66. ncbi request reprint Cardio-facio-cutaneous syndrome and moyamoya syndrome
    Yoshiko Ishiguro
    Department of Pediatrics, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Aichi 466 8550, Japan
    Brain Dev 24:245-9. 2002
    ..Contrast angiography demonstrated occlusion of both middle cerebral arteries. Cerebrovascular anomalies have not previously been reported in CFC syndrome. This is the first case of CFC syndrome associated with moyamoya syndrome...
  67. ncbi request reprint Current treatment of West syndrome in Japan
    Takeshi Tsuji
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Child Neurol 22:560-4. 2007
    ..Although therapeutic strategy and drug usage have not changed largely during these 10 years, 2 alterations were observed: an increased use of zonisamide and a shortened duration of adrenocorticotropic hormone therapy...
  68. doi request reprint Efficacy of a diazepam suppository at preventing febrile seizure recurrence during a single febrile illness
    Yu Hirabayashi
    Department of Pediatrics, Tosei General Hospital, 160 Nishioiwake cho, Seto, Aichi, Japan
    Brain Dev 31:414-8. 2009
    ..To assess the efficacy of diazepam suppositories at preventing febrile seizure recurrence during a single febrile illness to determine how to treat children with a febrile seizure on presentation at the hospital...
  69. ncbi request reprint Absence seizures in patients with localization-related epilepsy
    Ayako Sofue
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 25:422-6. 2003
    ..AS in patients with LRE will be relatively benign and transient, and will respond well to antiepileptic drugs...
  70. ncbi request reprint Amplitude spectral analysis of theta/alpha/beta waves in preterm infants
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    Pediatr Neurol 34:30-4. 2006
    ..In conclusion, maturational electroencephalographic changes assessed by amplitude spectral analysis were prominent in theta activities and were not remarkable in alpha or beta activities...
  71. ncbi request reprint The evolutionary change of flash visual evoked potentials in preterm infants with periventricular leukomalacia
    Toru Kato
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya, Aichi 466 8550, Japan
    Clin Neurophysiol 116:690-5. 2005
    ..The aim of this study was to prospectively investigate flash visual evoked potential (VEP) findings and their chronological changes in preterm infants with cystic periventricular leukomalacia (PVL) during the early neonatal period...
  72. ncbi request reprint Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Brain Dev 26:164-7. 2004
    ..When the efficacy of the first doses of PB and LD were compared, the efficacy rate was significantly higher for LD than for PB (P = 0.047). In conclusion, LD was effective for the cessation of seizures in patients with CwG...
  73. ncbi request reprint Long-term follow-up of patients with benign partial epilepsy in infancy
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Epilepsia 47:181-5. 2006
    ..The aim of this study was to investigate the long-term outcome of children with benign partial epilepsy in infancy (BPEI)...
  74. ncbi request reprint Comparison of two low dose ACTH therapies for West syndrome: their efficacy and side effect
    Yoko Kondo
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466 8560, Japan
    Brain Dev 27:326-30. 2005
    ..Adverse effects were not different between regimens A and B. 0.010 mg/kg per day of ACTH will be adequate for cryptogenic WS, but 0.015 mg/kg per day of ACTH is recommended for symptomatic WS...
  75. ncbi request reprint Abnormal sharp transients on electroencephalograms in preterm infants with periventricular leukomalacia
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    J Pediatr 143:26-30. 2003
    ..To determine the clinical significance of abnormal sharp transients other than positive rolandic sharp waves (PRS), electroencephalograms were used for the diagnosis of periventricular leukomalacia (PVL)...
  76. ncbi request reprint Posterior reversible encephalopathy syndrome in a child with bronchial asthma
    Hirokazu Kurahashi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Brain Dev 28:544-6. 2006
    ..We should be aware that PRES is a rare but important adverse event related to steroid therapy, because hypertension and water retention are major adverse effects of steroids...
  77. ncbi request reprint A case of subacute sclerosing panencephalitis preceded by epileptic seizures: evolutional EEG changes
    Tetsuo Kubota
    Department of Pediatrics, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 25:279-82. 2003
    ..In our case, EEG abnormalities were recognized before mental deterioration. Unexpected EEG changes in a patient with epilepsy could be a clue as to the diagnosis of SSPE...
  78. ncbi request reprint A case of infantile Alexander disease with a milder phenotype and a novel GFAP mutation, L90P
    Yoshiko Suzuki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Brain Dev 26:206-8. 2004
    ..The neurological deterioration was mild and appeared relatively late for infantile onset...
  79. doi request reprint Congenital infiltrating lipomatosis of the face with ipsilateral hemimegalencephaly, band heterotopia, and hypertrophy of brainstem and cerebellum
    Koichi Maruyama
    Department of Pediatric Neurology, Central Hospital, Aichi Prefectural Colony, Kasugai, Aichi, Japan
    Neuropediatrics 41:147-50. 2010
    ..His seizures were so intractable that they necessitated functional hemispherectomy. The lipomatous lesion was successfully resected without relapse. Psychomotor delay and left hemiplegia were observed at the last follow-up...
  80. doi request reprint Clustered subclinical seizures in a patient with acute encephalopathy with biphasic seizures and late reduced diffusion
    Mitsutaka Komatsu
    Department of Pediatrics, Urayasu Ichikawa Municipal Hospital, Urayasu, Japan
    Brain Dev 32:472-6. 2010
    ..aEEG is useful for continuous monitoring in children with acute encephalopathy, may disclose subclinical seizures, and can contribute to an objective evaluation of the efficacy of antiepileptic drugs...
  81. doi request reprint Callosal lesions and delirious behavior during febrile illness
    Akihisa Okumura
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Brain Dev 31:158-62. 2009
    ..Adding insight into the pathogenesis of this condition, our study revealed that callosal lesions are not uncommon in patients exhibiting delirious behavior during febrile illness...
  82. ncbi request reprint Ictal electroencephalographic findings of neonatal seizures in preterm infants
    Akihisa Okumura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Brain Dev 30:261-8. 2008
    ..The migration of ictal discharges was observed in two infants and a shift in two. There was no clear relation between seizure manifestation and ictal EEG foci, duration of seizures and morphology or propagation of ictal discharges...
  83. doi request reprint Nutritional state, maturational delay on electroencephalogram, and developmental outcome in extremely low birth weight infants
    Akihisa Okumura
    Department of Pediatrics, Juntendo University, School of Medicine, Bunkyo ku, Tokyo, Japan
    Brain Dev 32:613-8. 2010
    ..Among infants with undernutrition, developmental outcome was relatively worse in those with persistent dysmature patterns than those without...
  84. doi request reprint Acute encephalopathy with biphasic seizures and late reduced diffusion associated with hemophagocytic syndrome
    Rieko Tadokoro
    Department of Pediatrics, Koshigaya Municipal Hospital, Saitama, Japan
    Brain Dev 32:477-81. 2010
    ..These facts suggested that hypercytokinemia will be related to the pathogenesis of acute encephalopathy of our patient...
  85. ncbi request reprint Micturition induced seizures: ictal EEG and subtraction ictal SPECT findings
    Akihisa Okumura
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunky ku, Tokyo 113 8421, Japan
    Epilepsy Res 73:119-21. 2007
    ..Subtraction ictal single photon emission computed tomography revealed a significant increase in blood flow in the mesial frontal area...
  86. ncbi request reprint Ictal EEG in benign partial epilepsy in infancy
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Neurol 36:8-12. 2007
    ..Ictal electroencephalographic findings of patients with benign partial epilepsy in infancy were relatively uniform, suggesting the homogeneity of patients with benign partial epilepsy in infancy...
  87. ncbi request reprint Sharp waves in preterm infants with periventricular leukomalacia
    Ayako Sofue
    Department of Pediatrics, Okazaki City Hospital, Aichi, Japan
    Pediatr Neurol 29:214-7. 2003
    ..The application of a higher low-cut filter will be useful for the assessment of sharp transients in neonatal electroencephalography...
  88. doi request reprint The spectrum of acute encephalopathy with reduced diffusion in the unilateral hemisphere
    Akihisa Okumura
    Department of Pediatrics, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Eur J Paediatr Neurol 13:154-9. 2009
    ..No patients died, but 6 patients had various degrees of neurological sequelae. Acute encephalopathy with reduced diffusion in the unilateral hemisphere may be one of the representative phenotypes of acute encephalopathy...
  89. doi request reprint Phenotypic overlapping of trisomy 12p and Pallister-Killian syndrome
    Eisuke Inage
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Med Genet 53:159-61. 2010
    ..The microblepharon identified in our patient is a characteristic feature of 12p trisomy. Further patients are needed to establish the phenotypic difference between trisomy 12p and Pallister-Killian syndrome...
  90. ncbi request reprint Relationship between serum lactate level and periventricular leukomalacia
    Hiroyuki Kidokoro
    Department of Pediatrics, Anjo Kosei Hospital, 28 Tokoubann, Anjo cho, Anjo shi, Aichi 486 8510, Japan
    Brain Dev 29:656-9. 2007
    ..In conclusion, the serum lactate level was not elevated in preterm infants with PVL suggesting that the serum lactate level is not a useful predictor for the development of PVL in infants...
  91. doi request reprint The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion
    Naoyuki Tanuma
    Department of Pediatrics, Tokyo Metropolitan Fuchu Medical Center for the Disabled, Fuchu, Tokyo 183 0042, Japan
    Brain Dev 32:435-9. 2010
    ..A therapeutic strategy for axonal protection should be developed to prevent severe neurological impairment of AESD patients...
  92. doi request reprint Chronologic changes in neonatal EEG findings in periventricular leukomalacia
    Hiroyuki Kidokoro
    Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan
    Pediatrics 124:e468-75. 2009
    ..This study sought to clarify chronologic changes in neonatal electroencephalographic (EEG) findings in periventricular leukomalacia (PVL)...
  93. ncbi request reprint [A case of infantile epileptic encephalopathy with frequent focal motor status convulsivus: successful treatment with zonisamide]
    Ayako Sofue
    Department of Pediatrics, Okazaki City Hospital, Okazaki, Aichi
    No To Hattatsu 34:43-8. 2002
    ..The seizures were resistant to the multiple antiepileptic drugs, but zonisamide achieved full seizure control as well as improvement of the EEG. Her psychomotor development was severely retarded at 3 years of age...
  94. ncbi request reprint Unconsciousness and delirious behavior in children with febrile seizures
    Akihisa Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Neurol 30:316-9. 2004
    ..Careful diagnostic evaluation is necessary when a child with febrile seizures has associated prolonged unconsciousness or delirious behavior...
  95. ncbi request reprint ACTH therapy for generalized seizures other than spasms
    Akihisa Okumura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Seizure 15:469-75. 2006
    ..We reviewed our experience with ACTH for the treatment of intractable generalized seizures other than spasms...
  96. ncbi request reprint Combination therapy with intraventricular interferon-alpha and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay
    Shinya Hara
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Brain Dev 25:367-9. 2003
    ..After intraventricular ribavirin was combined with INF-alpha therapy, no further improvement was observed. The neurological disability gradually progressed, although the amount of virus RNA remained low...
  97. ncbi request reprint [A case with frontal lobe epilepsy presenting with absence seizures as cardinal manifestation: ictal EEG findings]
    Koichi Maruyama
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya
    No To Hattatsu 34:72-6. 2002
    ..Both the seizures were well controlled by the combination of phenytoin and high dose sodium valproate...
  98. ncbi request reprint Mild oliguria in preterm infants who later developed periventricular leukomalacia
    Hiroyuki Kidokoro
    Department of Pediatrics, Kasugai Municipal Hospital, Kasugai, Aichi, Japan
    Brain Dev 29:142-6. 2007
    ..The preterm infants who later developed PVL had mild but significant oliguria during the first 24h of life. This suggests that preterm infants with PVL will have renal involvement immediately after birth...
  99. ncbi request reprint Serum levels of cytokines and EEG findings in children with influenza associated with mild neurological complications
    Yukiko Fukumoto
    Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan
    Brain Dev 29:425-30. 2007
    ..Further studies will be necessary for investigating that IL-6 has the diagnostic value for differentiation between severe encephalopathy and mild neurological complications in children with influenza...
  100. ncbi request reprint Diffusion tensor imaging in infants with basal ganglia-thalamic lesions
    Akihisa Okumura
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Eur J Paediatr Neurol 12:412-6. 2008
    ..Diffusion tensor imaging will be useful to detect white matter abnormalities in normal-appearing white matter on conventional MRI...
  101. ncbi request reprint Prognostic value of positron emission tomography in cryptogenic West syndrome
    Kazuya Itomi
    Department of Paediatrics, Nagoya University School of Medicine, Japan
    Dev Med Child Neurol 44:107-11. 2002
    ..PET may be a useful tool in evaluating the prognosis in infants with cryptogenic West syndrome...