T Okamoto

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells
    K E Traber
    Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan
    Int Immunol 11:143-50. 1999
  2. pmc A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome
    T Nagaya
    Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    J Clin Invest 106:393-402. 2000
  3. ncbi request reprint Human chorionic gonadotropin beta-core fragment is directly produced by cancer cells
    T Okamoto
    Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
    Life Sci 68:861-72. 2001
  4. ncbi request reprint Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium
    Nobuyuki Watanabe
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Biochem Biophys Res Commun 294:1121-9. 2002
  5. ncbi request reprint Induction of OGG1 gene expression by HIV-1 Tat
    Kenichi Imai
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601
    J Biol Chem 280:26701-13. 2005
  6. pmc Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat
    Julie K Jadlowsky
    Division of Infectious Diseases, Department of Medicine, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Retrovirology 5:63. 2008
  7. ncbi request reprint [Positive and negative regulation of transcription from HIV provirus]
    Takashi Okamoto
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences
    Uirusu 61:81-9. 2011
  8. ncbi request reprint NF-kappa B signaling and carcinogenesis
    Takashi Okamoto
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Curr Pharm Des 13:447-62. 2007
  9. ncbi request reprint Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization
    T Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan
    Cytogenet Cell Genet 82:105-6. 1998
  10. ncbi request reprint Protecting skin photoaging by NF-kappaB inhibitor
    Kiyotaka Tanaka
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Curr Drug Metab 11:431-5. 2010

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells
    K E Traber
    Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan
    Int Immunol 11:143-50. 1999
    ..These observations indicate that the monovalent gold compound AuTG is a potentially useful drug for the treatment of patients infected with HIV...
  2. pmc A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome
    T Nagaya
    Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    J Clin Invest 106:393-402. 2000
    ..These results suggest that NF-kappa B activation by TNF-alpha is involved in the pathogenesis of euthyroid sick syndrome and that CAM could help prevent a decrease in serum T(3) levels and thus ameliorate euthyroid sick syndrome...
  3. ncbi request reprint Human chorionic gonadotropin beta-core fragment is directly produced by cancer cells
    T Okamoto
    Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
    Life Sci 68:861-72. 2001
    ..Also, reduced levels of hCGbeta cf in the serum compared with that of intact hCG or free hCGbeta are likely due to its short half-life...
  4. ncbi request reprint Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium
    Nobuyuki Watanabe
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Biochem Biophys Res Commun 294:1121-9. 2002
    ..In fact, we found that RSFs showed greater sensitivity to the cell proliferative effect of PDGF. T his aberrant gene expression profile suggests that RSF may have retained the premature phenotype of primordial synoviocytes...
  5. ncbi request reprint Induction of OGG1 gene expression by HIV-1 Tat
    Kenichi Imai
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601
    J Biol Chem 280:26701-13. 2005
    ..These findings collectively indicate the possibility that Tat may play a role in maintenance of the genetic integrity of the proviral and host cellular genomes by up-regulating OGG1 as a feed-forward mechanism...
  6. pmc Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat
    Julie K Jadlowsky
    Division of Infectious Diseases, Department of Medicine, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Retrovirology 5:63. 2008
    ..This represents a critical and necessary step for the stimulation of transcriptional elongation. Therefore, CycT1 may serve as a potential target for the development of anti-HIV therapies...
  7. ncbi request reprint [Positive and negative regulation of transcription from HIV provirus]
    Takashi Okamoto
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences
    Uirusu 61:81-9. 2011
    ..HIV is unique in that it contains virus-specific transcriptional activator called Tat...
  8. ncbi request reprint NF-kappa B signaling and carcinogenesis
    Takashi Okamoto
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Curr Pharm Des 13:447-62. 2007
    ..In this review, we have attempted to overview the possible involvement of NF-kappaB in cancer and discuss the feasibility of anti-cancer strategy with NF-kappaB and its signaling cascade as novel molecular targets...
  9. ncbi request reprint Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization
    T Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan
    Cytogenet Cell Genet 82:105-6. 1998
  10. ncbi request reprint Protecting skin photoaging by NF-kappaB inhibitor
    Kiyotaka Tanaka
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Curr Drug Metab 11:431-5. 2010
    ..We also found that these NF-kappaB inhibitors could inhibit the UVB-induced proliferation of keratinocytes and melanocytes in the mouse skin. These findings suggest that NF-kappaB inhibitors are useful in preventing the skin photoaging...
  11. ncbi request reprint NF-kappaB and rheumatic diseases
    Takashi Okamoto
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Endocr Metab Immune Disord Drug Targets 6:359-72. 2006
    ..In this review, I have attempted to overview the pathologic involvement of NF-kappaB in rheumatic diseases and discuss the feasibility of a therapeutic strategy with NF-kappaB and its signaling cascade as novel molecular targets...
  12. ncbi request reprint Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator
    H Uranishi
    Department of Molecular Genetics and First Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Biol Chem 276:13395-401. 2001
    ..These results suggest that TLS acts as a coactivator of NF-kappaB and plays a pivotal role in the NF-kappaB-mediated transactivation...
  13. ncbi request reprint Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats
    T Tetsuka
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Biol Chem 275:4383-90. 2000
    ..These data indicate that AES acts as a corepressor for NF-kappaB and suggest that AES may play a pivotal role in the regulation of NF-kappaB target genes...
  14. ncbi request reprint Human chorionic gonadotropin (hCG) beta-core fragment is produced by degradation of hCG or free hCG beta in gestational trophoblastic tumors: a possible marker for early detection of persistent postmolar gestational trophoblastic disease
    T Okamoto
    Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
    J Endocrinol 171:435-43. 2001
    ....
  15. ncbi request reprint Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose
    S Yoshida
    Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan
    Int Immunol 11:151-8. 1999
    ..These results indicate that one of the anti-rheumatic actions of AuTG might be through its inhibitory action on NF-kappaB...
  16. ncbi request reprint Expression of nm23-H1 in hydatidiform mole and its relationship with the development of postmolar disease
    K Iwase
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
    Gynecol Obstet Invest 51:228-32. 2001
    ..The present data suggest an association of nm23-H1 for the proliferation activity of trophoblast, and its increased expression may influence the development of persistent trophoblastic disease...
  17. ncbi request reprint Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage
    T Ando
    Department of Molecular Genetics and First Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Biol Chem 276:42971-7. 2001
    ..These findings suggest that p21 plays a regulatory role in the maintenance of cell cycle arrest at G(2) by blocking the interaction of Cdc25C with PCNA...
  18. ncbi request reprint Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA
    H Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
    Biochem Biophys Res Commun 279:494-9. 2000
    ..These reciprocal actions between Tat and CIITA not only explains the functional impairment of APC in HIV-1 infection but also rationalizes the suppression of HIV-1 virus load by induction of CIITA such as IFN-gamma...
  19. ncbi request reprint NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2
    J P Yang
    Department of Molecular Genetics, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Oncogene 18:5177-86. 1999
    ..The previous findings that 53BP2 bound to p53 and Bcl-2 together with our present observations suggest that 53BP2 may play a central role in the regulation of apoptosis and cell growth...
  20. ncbi request reprint Inhibition of the DNA-binding activity of NF-kappa B by gold compounds in vitro
    J P Yang
    Department of Molecular Genetics, Nagoya City University Medical School, Japan
    FEBS Lett 361:89-96. 1995
    ..This redox mechanism may provide an explanation for the observed efficacy of gold compounds in the treatment of rheumatoid arthritis...
  21. ncbi request reprint Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells
    T Sanda
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Leukemia 21:2344-53. 2007
    ..These findings suggest that NCH-51 exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA. This study indicates the therapeutic efficacy of NCH-51 and novel insights for anti-HDAC therapy...
  22. ncbi request reprint Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor
    J P Yang
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Biol Chem 274:15662-70. 1999
    ..These observations indicate that RAI is another inhibitor of NF-kappaB in addition to IkappaB proteins and may confer an alternative mechanism of regulation...
  23. ncbi request reprint Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor
    T Sanda
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Leukemia 20:590-8. 2006
    ..Moreover, ACHP exhibited strong apoptosis-inducing activity in fresh ATL cells. These findings indicate that ACHP and its derivatives are effective in inducing ATL cell death and thus feasible candidates for the treatment of ATL...
  24. ncbi request reprint Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridization
    J P Yang
    Department of Molecular Genetics, Nagoya City University Medical School, Japan
    Cytogenet Cell Genet 78:61-2. 1997
  25. ncbi request reprint Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines
    T Mori
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Japan
    FEBS Lett 465:124-8. 2000
    ....
  26. doi request reprint Inhibition of inflammatory cytokine production from rheumatoid synovial fibroblasts by a novel IkappaB kinase inhibitor
    Atsushi Tsuchiya
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Pharmacol Exp Ther 333:236-43. 2010
    ..These findings indicate that such a IKKbeta inhibitor could be a feasible candidate for an antirheumatic drug...
  27. ncbi request reprint [Regulatory system of HIV transcription as a feasible therapeutic target]
    Kenichi Imai
    Tanpakushitsu Kakusan Koso 52:1121-7. 2007
  28. ncbi request reprint N-acetyl-L-cysteine enhances chemotherapeutic effect on prostate cancer cells
    Keiichi Tozawa
    Department of Urology, Nagoya City University Medical School, Nagoya, Japan
    Urol Res 30:53-8. 2002
    ..These observations indicate that NF-kappaB can be a target of new adjuvant therapy against hormone refractory prostate cancer...
  29. ncbi request reprint Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor
    Takaomi Sanda
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 08601, Japan
    Clin Cancer Res 11:1974-82. 2005
    ....
  30. ncbi request reprint Smad3 is acetylated by p300/CBP to regulate its transactivation activity
    Y Inoue
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, Japan
    Oncogene 26:500-8. 2007
    ..These results suggest that acetylation of Smad3 by p300/CBP regulates positively its transcriptional activity...
  31. ncbi request reprint Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB
    Kiyotaka Tanaka
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Eur J Pharmacol 565:212-9. 2007
    ..These findings suggest that Magnolia extract and its active component magnolol can be used to prevent the skin photoaging via inhibiting NF-kappaB by external topical application...
  32. pmc A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling
    Nan Gao
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Biol Chem 285:28097-104. 2010
    ....
  33. ncbi request reprint Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor kappaB inhibitor, parthenolide
    Kiyotaka Tanaka
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Aichi, Japan
    J Pharmacol Exp Ther 315:624-30. 2005
    ..We also found that parthenolide could inhibit the UVB-induced proliferation of keratinocytes and melanocytes in the mouse skin. These findings suggest that NF-kappaB inhibitors should be useful for the prevention of skin photoaging...
  34. ncbi request reprint Thioredoxin and mechanism of inflammatory response
    Takashi Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Methods Enzymol 347:349-60. 2002
  35. ncbi request reprint Gold compounds inhibit adhesion of human cancer cells to vascular endothelial cells
    Keiichi Tozawa
    Department of Urology, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467, Japan
    Cancer Lett 196:93-100. 2003
    ..These observations indicate the involvement of NF-kappaB in cancer metastasis and suggest the feasibility of using gold compounds to prevent metastasis...
  36. ncbi request reprint Transcriptional repression of human immunodeficiency virus type 1 by AP-4
    Kenichi Imai
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Biol Chem 281:12495-505. 2006
    ....
  37. ncbi request reprint Knock down of hSNF5/Ini1 causes cell cycle arrest and apoptosis in a p53-dependent manner
    Hiroyuki Kato
    Department of Virology III, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
    Biochem Biophys Res Commun 361:580-5. 2007
    ..These results may in part account for molecular mechanisms of rhabdoid tumor formation...
  38. ncbi request reprint Resistance to multiple agent chemotherapy including cisplatin after chronic low-dose oral etoposide administration in gestational choriocarcinoma
    T Okamoto
    Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
    Gynecol Obstet Invest 52:139-41. 2001
    ..Although the patient was expected to have a good chance of cure using combination chemotherapy, the lesion was resistant to multiple-agent chemotherapy including cisplatin...
  39. ncbi request reprint Expression and localization of nm23-H1 in the human placenta
    T Okamoto
    Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
    Arch Gynecol Obstet 266:1-4. 2002
    ..These findings suggest that nm23-H1 is involved in the differentiation process of the trophoblast, and high levels of nm23-H1 expression seem to reflect the proliferating, less differentiated state of that reserve...
  40. pmc Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis
    Satoshi Kanazawa
    Departments of Molecular and Cellular Biology and Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Nagoya 467 8601, Japan
    Proc Natl Acad Sci U S A 103:14465-70. 2006
    ..Thus, aberrant expression of MHC class II in joints facilitates the development of severe erosive inflammatory polyarthritis, which is very similar to RA...
  41. ncbi request reprint [NF-kappaB as a therapeutic target of rheumatoid arthritis]
    Takashi Okamoto
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho Meneki Gakkai Kaishi 30:383-9. 2007
    ..In this review, we have attempted to analyze various pathological steps of rheumatoid arthritis especially by depicting the steps that involve NF-kappaB. We also discuss possible therapeutic strategies with NF-kappaB as a major target...
  42. ncbi request reprint Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kappaB and Bcl-2 family proteins
    Naoko Takahashi
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
    Genes Cells 10:803-11. 2005
    ..The regulatory network of the 53BP2S-mediated apoptosis cascade including its interacting proteins is discussed...
  43. ncbi request reprint NF-kappa B p65 transactivation domain is involved in the NF-kappa B-inducing kinase pathway
    Xu Jiang
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Biochem Biophys Res Commun 301:583-90. 2003
    ....
  44. ncbi request reprint Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts
    Kiichiro Ando
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Oncogene 22:7796-803. 2003
    ..Thus, RSF may have re-acquired the primordial phenotype, accounting for the hyperproliferation and aggressive invasiveness, exhibiting tumor-like phenotype...
  45. ncbi request reprint Calpain is involved in the HIV replication from the latently infected OM10.1 cells
    Futoshi Teranishi
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Biochem Biophys Res Commun 303:940-6. 2003
    ....
  46. ncbi request reprint Inhibition of the NF-kappaB transcriptional activity by protein kinase A
    Naoko Takahashi
    Department of Molecular Genetics, Nagoya City University Medical School, Japan
    Eur J Biochem 269:4559-65. 2002
    ..Thus, the inhibitory action of the cAMP/PKA pathway on the transcriptional activity of NF-kappaB appears to be exhibited by modifying the C-terminal transactivation domain of p65, either directly or indirectly...
  47. ncbi request reprint 3-methylcholanthrene activates human immunodeficiency virus type 1 replication via aryl hydrocarbon receptor
    Hirokazu Ohata
    Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Aichi 467 8601, Japan
    Microbiol Immunol 47:363-70. 2003
    ..Our observations indicate that chronic exposure of the HIV-1 infected individuals to PAHs may be contributable to the clinical development of acquired immunodeficiency syndrome (AIDS) among the individuals infected with HIV...
  48. ncbi request reprint The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536
    Xu Jiang
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Japan
    J Biol Chem 278:919-26. 2003
    ..These observations provide evidence for a crucial role of the NIK-IKKalpha cascade for NF-kappaB activation in LTbetaR signaling...
  49. doi request reprint AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65
    Nan Gao
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Biol Chem 283:7834-43. 2008
    ..These findings indicate a positive role of AKIP1 in NF-kappaB signaling and suggest a novel mechanism by which AKIP1 augments the transcriptional competence of NF-kappaB...
  50. pmc RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions
    Norio Takada
    Department of Molecular Genetics, Nagoya City University Medical School, Japan
    J Virol 76:8019-30. 2002
    ..These findings indicate that RAI acts as an efficient inhibitor of HIV-1 gene expression in which both NF-kappaB and Sp1 play major roles...
  51. ncbi request reprint RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator
    Toshifumi Tetsuka
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Eur J Biochem 271:3741-51. 2004
    ..These data suggest that RHA is an essential component of the transactivation complex by mediating the transcriptional activity of NF-kappaB...
  52. ncbi request reprint Low molecular weight lignin suppresses activation of NF-kappaB and HIV-1 promoter
    Shinya Mitsuhashi
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Bioorg Med Chem 16:2645-50. 2008
    ..Low molecular lignin may be a beneficial material or drug leads as a new class for AIDS and NF-kappaB-related diseases...
  53. doi request reprint Reactivation of latent HIV-1 infection by the periodontopathic bacterium Porphyromonas gingivalis involves histone modification
    Kenichi Imai
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Immunol 182:3688-95. 2009
    ..These results suggest that periodontal diseases could act as a risk factor for HIV-1 reactivation in infected individuals and might contribute to the systemic dissemination of the virus...
  54. pmc Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294
    Kenichi Imai
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Biol Chem 285:16538-45. 2010
    ..These results suggest that G9a is responsible for the transcriptional quiescence of latent HIV-1 provirus and provide a molecular basis for understanding the mechanism by which HIV-1 latency is maintained...
  55. ncbi request reprint Estrogen stimulates transcription of human immunodeficiency virus type 1 (HIV-1)
    Daichi Katagiri
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Int Immunopharmacol 6:170-81. 2006
    ..These findings suggest a contribution of estrogen for HIV-1 replication through ERalpha by augmenting Sp1 DNA-binding and transcriptional activity...
  56. ncbi request reprint Inhibitory effects of IFN-gamma on HIV-1 replication in latently infected cells
    Lilen C Sarol
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Biochem Biophys Res Commun 291:890-6. 2002
    ..Simvastatin did not show any unfavorable effects on HIV replication, thus could be used safely unless there are any drug interactions when administered...
  57. doi request reprint Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin
    Kaori Asamitsu
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Biochem 144:581-9. 2008
    ..When we treated the cell lines, OM10.1 and Molt4/IIIB, in which HIV-1 is latently and chronically infected, we found a strong suppressive effect of NAM on HIV-1 viral replication upon stimulation with TNF-alpha...
  58. ncbi request reprint The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells
    Kazuaki Enya
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    J Leukoc Biol 83:190-9. 2008
    ..These results indicate that the reduction in the activity and interaction of HDAC1 with Sp1 are critical for the constitutive IL-1 alpha gene expression...
  59. ncbi request reprint Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells
    Yuka Itoh
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Biol Pharm Bull 30:1140-3. 2007
    ..These results suggest that DHT inhibits the TNFalpha-induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease...
  60. ncbi request reprint Establishment of a simple and quantitative immunospot assay for detecting anti-type II collagen antibody using an infrared fluorescence imaging system (IFIS)
    Shusuke Ota
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Immunol Methods 299:189-98. 2005
    ..The method and its possible applications are discussed...
  61. ncbi request reprint RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit
    Kaori Asamitsu
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Biol Chem 278:26879-87. 2003
    ..These data suggest that AO7 interacts with the p65 TAD and modulates its transcriptional activity...
  62. pmc Inhibition of human immunodeficiency virus type 1 replication in latently infected cells by a novel IkappaB kinase inhibitor
    Ann Florence B Victoriano
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Antimicrob Agents Chemother 50:547-55. 2006
    ..These findings suggest that ACHP acts as a potent suppressor of TNF-alpha-induced HIV replication in latently infected cells and that this inhibition is mediated through suppression of IKK activity...
  63. ncbi request reprint Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions
    Akira Okano
    Department of Neuroplasticity, Research Center on Aging and Adaptation, University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Brain Res 967:210-25. 2003
    ....
  64. ncbi request reprint Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treated in vivo model
    Hiroki Urashima
    Ako Research Institute, Division of Dermatologicals and Ophthalmologicals, Otsuka Pharmaceutical Co, Ltd, Hyogo 678 0207, Japan
    Cornea 23:613-9. 2004
    ..Furthermore, we attempted to evaluate the effects of rebamipide on the wound healing of N-acetylcysteine-treated eyes...
  65. ncbi request reprint c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis
    Satoshi Kanazawa
    Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
    Oncogene 22:5707-11. 2003
    ..Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc...
  66. pmc Low pH enhances Sp1 DNA binding activity and interaction with TBP
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Nucleic Acids Res 31:4523-30. 2003
    ..These findings indicate that pH changes significantly modulate the activity of Sp1 and thus contribute to the cellular response under hypoxic or acidic conditions...
  67. pmc TRAF6-NF-kappaB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes
    Takayuki Matsumura
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Immunology 109:127-36. 2003
    ....
  68. ncbi request reprint Involvement of RelA-associated inhibitor in regulation of trophoblast differentiation via interaction with transcriptional factor specificity protein-1
    Ryoko Minekawa
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Endocrinology 148:5803-10. 2007
    ..Taken together, these findings suggest that RAI may be involved in the regulation of trophoblast differentiation via interaction with Sp1...