Research Topics
Genomes and Genes
| T OkamotoSummaryAffiliation: Nagoya City University Country: Japan Publications
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Detail Information
Publications
Protecting skin photoaging by NF-kappaB inhibitorKiyotaka Tanaka
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Curr Drug Metab 11:431-5. 2010..We also found that these NF-kappaB inhibitors could inhibit the UVB-induced proliferation of keratinocytes and melanocytes in the mouse skin. These findings suggest that NF-kappaB inhibitors are useful in preventing the skin photoaging...- Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cellsK E Traber
Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan
Int Immunol 11:143-50. 1999..These observations indicate that the monovalent gold compound AuTG is a potentially useful drug for the treatment of patients infected with HIV... 
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndromeT Nagaya
Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
J Clin Invest 106:393-402. 2000..These results suggest that NF-kappa B activation by TNF-alpha is involved in the pathogenesis of euthyroid sick syndrome and that CAM could help prevent a decrease in serum T(3) levels and thus ameliorate euthyroid sick syndrome...- Human chorionic gonadotropin beta-core fragment is directly produced by cancer cellsT Okamoto
Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
Life Sci 68:861-72. 2001..Also, reduced levels of hCGbeta cf in the serum compared with that of intact hCG or free hCGbeta are likely due to its short half-life... - Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synoviumNobuyuki Watanabe
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan
Biochem Biophys Res Commun 294:1121-9. 2002..In fact, we found that RSFs showed greater sensitivity to the cell proliferative effect of PDGF. T his aberrant gene expression profile suggests that RSF may have retained the premature phenotype of primordial synoviocytes... - Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading TatJulie K Jadlowsky
Division of Infectious Diseases, Department of Medicine, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Retrovirology 5:63. 2008..This represents a critical and necessary step for the stimulation of transcriptional elongation. Therefore, CycT1 may serve as a potential target for the development of anti-HIV therapies... - [Positive and negative regulation of transcription from HIV provirus]Takashi Okamoto
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences
Uirusu 61:81-9. 2011..HIV is unique in that it contains virus-specific transcriptional activator called Tat... - NF-kappa B signaling and carcinogenesisTakashi Okamoto
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
Curr Pharm Des 13:447-62. 2007..In this review, we have attempted to overview the possible involvement of NF-kappaB in cancer and discuss the feasibility of anti-cancer strategy with NF-kappaB and its signaling cascade as novel molecular targets... - Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridizationT Okamoto
Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan
Cytogenet Cell Genet 82:105-6. 1998 - NF-kappaB and rheumatic diseasesTakashi Okamoto
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
Endocr Metab Immune Disord Drug Targets 6:359-72. 2006..In this review, I have attempted to overview the pathologic involvement of NF-kappaB in rheumatic diseases and discuss the feasibility of a therapeutic strategy with NF-kappaB and its signaling cascade as novel molecular targets... - Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivatorH Uranishi
Department of Molecular Genetics and First Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
J Biol Chem 276:13395-401. 2001..These results suggest that TLS acts as a coactivator of NF-kappaB and plays a pivotal role in the NF-kappaB-mediated transactivation... - Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeatsT Tetsuka
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
J Biol Chem 275:4383-90. 2000..These data indicate that AES acts as a corepressor for NF-kappaB and suggest that AES may play a pivotal role in the regulation of NF-kappaB target genes... - Human chorionic gonadotropin (hCG) beta-core fragment is produced by degradation of hCG or free hCG beta in gestational trophoblastic tumors: a possible marker for early detection of persistent postmolar gestational trophoblastic diseaseT Okamoto
Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
J Endocrinol 171:435-43. 2001.... - Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucoseS Yoshida
Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Japan
Int Immunol 11:151-8. 1999..These results indicate that one of the anti-rheumatic actions of AuTG might be through its inhibitory action on NF-kappaB... - Expression of nm23-H1 in hydatidiform mole and its relationship with the development of postmolar diseaseK Iwase
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
Gynecol Obstet Invest 51:228-32. 2001..The present data suggest an association of nm23-H1 for the proliferation activity of trophoblast, and its increased expression may influence the development of persistent trophoblastic disease... - Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damageT Ando
Department of Molecular Genetics and First Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
J Biol Chem 276:42971-7. 2001..These findings suggest that p21 plays a regulatory role in the maintenance of cell cycle arrest at G(2) by blocking the interaction of Cdc25C with PCNA... - Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITAH Okamoto
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
Biochem Biophys Res Commun 279:494-9. 2000..These reciprocal actions between Tat and CIITA not only explains the functional impairment of APC in HIV-1 infection but also rationalizes the suppression of HIV-1 virus load by induction of CIITA such as IFN-gamma... - NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2J P Yang
Department of Molecular Genetics, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
Oncogene 18:5177-86. 1999..The previous findings that 53BP2 bound to p53 and Bcl-2 together with our present observations suggest that 53BP2 may play a central role in the regulation of apoptosis and cell growth... - Inhibition of the DNA-binding activity of NF-kappa B by gold compounds in vitroJ P Yang
Department of Molecular Genetics, Nagoya City University Medical School, Japan
FEBS Lett 361:89-96. 1995..This redox mechanism may provide an explanation for the observed efficacy of gold compounds in the treatment of rheumatoid arthritis... - Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cellsT Sanda
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Leukemia 21:2344-53. 2007..These findings suggest that NCH-51 exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA. This study indicates the therapeutic efficacy of NCH-51 and novel insights for anti-HDAC therapy... - Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitorJ P Yang
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
J Biol Chem 274:15662-70. 1999..These observations indicate that RAI is another inhibitor of NF-kappaB in addition to IkappaB proteins and may confer an alternative mechanism of regulation... - Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitorT Sanda
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Leukemia 20:590-8. 2006..Moreover, ACHP exhibited strong apoptosis-inducing activity in fresh ATL cells. These findings indicate that ACHP and its derivatives are effective in inducing ATL cell death and thus feasible candidates for the treatment of ATL... - Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridizationJ P Yang
Department of Molecular Genetics, Nagoya City University Medical School, Japan
Cytogenet Cell Genet 78:61-2. 1997 - Aberrant overexpression of 53BP2 mRNA in lung cancer cell linesT Mori
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Japan
FEBS Lett 465:124-8. 2000.... 
Inhibition of inflammatory cytokine production from rheumatoid synovial fibroblasts by a novel IkappaB kinase inhibitorAtsushi Tsuchiya
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
J Pharmacol Exp Ther 333:236-43. 2010..These findings indicate that such a IKKbeta inhibitor could be a feasible candidate for an antirheumatic drug...- [Regulatory system of HIV transcription as a feasible therapeutic target]Kenichi Imai
Tanpakushitsu Kakusan Koso 52:1121-7. 2007 - N-acetyl-L-cysteine enhances chemotherapeutic effect on prostate cancer cellsKeiichi Tozawa
Department of Urology, Nagoya City University Medical School, Nagoya, Japan
Urol Res 30:53-8. 2002..These observations indicate that NF-kappaB can be a target of new adjuvant therapy against hormone refractory prostate cancer... - Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitorTakaomi Sanda
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-08601, Japan
Clin Cancer Res 11:1974-82. 2005.... - Smad3 is acetylated by p300/CBP to regulate its transactivation activityY Inoue
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, Japan
Oncogene 26:500-8. 2007..These results suggest that acetylation of Smad3 by p300/CBP regulates positively its transcriptional activity... - Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaBKiyotaka Tanaka
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
Eur J Pharmacol 565:212-9. 2007..These findings suggest that Magnolia extract and its active component magnolol can be used to prevent the skin photoaging via inhibiting NF-kappaB by external topical application... - A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signalingNan Gao
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
J Biol Chem 285:28097-104. 2010.... - Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor kappaB inhibitor, parthenolideKiyotaka Tanaka
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Aichi, Japan
J Pharmacol Exp Ther 315:624-30. 2005..We also found that parthenolide could inhibit the UVB-induced proliferation of keratinocytes and melanocytes in the mouse skin. These findings suggest that NF-kappaB inhibitors should be useful for the prevention of skin photoaging... - Thioredoxin and mechanism of inflammatory responseTakashi Okamoto
Department of Molecular Genetics, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601, Japan
Methods Enzymol 347:349-60. 2002 - Gold compounds inhibit adhesion of human cancer cells to vascular endothelial cellsKeiichi Tozawa
Department of Urology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan
Cancer Lett 196:93-100. 2003..These observations indicate the involvement of NF-kappaB in cancer metastasis and suggest the feasibility of using gold compounds to prevent metastasis... - Transcriptional repression of human immunodeficiency virus type 1 by AP-4Kenichi Imai
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
J Biol Chem 281:12495-505. 2006.... - Knock down of hSNF5/Ini1 causes cell cycle arrest and apoptosis in a p53-dependent mannerHiroyuki Kato
Department of Virology III, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
Biochem Biophys Res Commun 361:580-5. 2007..These results may in part account for molecular mechanisms of rhabdoid tumor formation... - Resistance to multiple agent chemotherapy including cisplatin after chronic low-dose oral etoposide administration in gestational choriocarcinomaT Okamoto
Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
Gynecol Obstet Invest 52:139-41. 2001..Although the patient was expected to have a good chance of cure using combination chemotherapy, the lesion was resistant to multiple-agent chemotherapy including cisplatin... - Expression and localization of nm23-H1 in the human placentaT Okamoto
Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan
Arch Gynecol Obstet 266:1-4. 2002..These findings suggest that nm23-H1 is involved in the differentiation process of the trophoblast, and high levels of nm23-H1 expression seem to reflect the proliferating, less differentiated state of that reserve... - Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritisSatoshi Kanazawa
Departments of Molecular and Cellular Biology and Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Nagoya 467-8601, Japan
Proc Natl Acad Sci U S A 103:14465-70. 2006..Thus, aberrant expression of MHC class II in joints facilitates the development of severe erosive inflammatory polyarthritis, which is very similar to RA... - [NF-kappaB as a therapeutic target of rheumatoid arthritis]Takashi Okamoto
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences
Nihon Rinsho Meneki Gakkai Kaishi 30:383-9. 2007..In this review, we have attempted to analyze various pathological steps of rheumatoid arthritis especially by depicting the steps that involve NF-kappaB. We also discuss possible therapeutic strategies with NF-kappaB as a major target... - Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kappaB and Bcl-2 family proteinsNaoko Takahashi
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
Genes Cells 10:803-11. 2005..The regulatory network of the 53BP2S-mediated apoptosis cascade including its interacting proteins is discussed... - NF-kappa B p65 transactivation domain is involved in the NF-kappa B-inducing kinase pathwayXu Jiang
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
Biochem Biophys Res Commun 301:583-90. 2003.... - Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblastsKiichiro Ando
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
Oncogene 22:7796-803. 2003..Thus, RSF may have re-acquired the primordial phenotype, accounting for the hyperproliferation and aggressive invasiveness, exhibiting tumor-like phenotype... - Calpain is involved in the HIV replication from the latently infected OM10.1 cellsFutoshi Teranishi
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan
Biochem Biophys Res Commun 303:940-6. 2003.... - Inhibition of the NF-kappaB transcriptional activity by protein kinase ANaoko Takahashi
Department of Molecular Genetics, Nagoya City University Medical School, Japan
Eur J Biochem 269:4559-65. 2002..Thus, the inhibitory action of the cAMP/PKA pathway on the transcriptional activity of NF-kappaB appears to be exhibited by modifying the C-terminal transactivation domain of p65, either directly or indirectly... - 3-methylcholanthrene activates human immunodeficiency virus type 1 replication via aryl hydrocarbon receptorHirokazu Ohata
Department of Molecular Genetics, Nagoya City University Medical School, Nagoya, Aichi 467-8601, Japan
Microbiol Immunol 47:363-70. 2003..Our observations indicate that chronic exposure of the HIV-1 infected individuals to PAHs may be contributable to the clinical development of acquired immunodeficiency syndrome (AIDS) among the individuals infected with HIV... - The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536Xu Jiang
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Japan
J Biol Chem 278:919-26. 2003..These observations provide evidence for a crucial role of the NIK-IKKalpha cascade for NF-kappaB activation in LTbetaR signaling... - AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65Nan Gao
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
J Biol Chem 283:7834-43. 2008..These findings indicate a positive role of AKIP1 in NF-kappaB signaling and suggest a novel mechanism by which AKIP1 augments the transcriptional competence of NF-kappaB... - RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actionsNorio Takada
Department of Molecular Genetics, Nagoya City University Medical School, Japan
J Virol 76:8019-30. 2002..These findings indicate that RAI acts as an efficient inhibitor of HIV-1 gene expression in which both NF-kappaB and Sp1 play major roles... - RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivatorToshifumi Tetsuka
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
Eur J Biochem 271:3741-51. 2004..These data suggest that RHA is an essential component of the transactivation complex by mediating the transcriptional activity of NF-kappaB... - Low molecular weight lignin suppresses activation of NF-kappaB and HIV-1 promoterShinya Mitsuhashi
Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
Bioorg Med Chem 16:2645-50. 2008..Low molecular lignin may be a beneficial material or drug leads as a new class for AIDS and NF-kappaB-related diseases... - Reactivation of latent HIV-1 infection by the periodontopathic bacterium Porphyromonas gingivalis involves histone modificationKenichi Imai
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Immunol 182:3688-95. 2009..These results suggest that periodontal diseases could act as a risk factor for HIV-1 reactivation in infected individuals and might contribute to the systemic dissemination of the virus... - Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294Kenichi Imai
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
J Biol Chem 285:16538-45. 2010..These results suggest that G9a is responsible for the transcriptional quiescence of latent HIV-1 provirus and provide a molecular basis for understanding the mechanism by which HIV-1 latency is maintained... - Estrogen stimulates transcription of human immunodeficiency virus type 1 (HIV-1)Daichi Katagiri
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan
Int Immunopharmacol 6:170-81. 2006..These findings suggest a contribution of estrogen for HIV-1 replication through ERalpha by augmenting Sp1 DNA-binding and transcriptional activity... - Inhibitory effects of IFN-gamma on HIV-1 replication in latently infected cellsLilen C Sarol
Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
Biochem Biophys Res Commun 291:890-6. 2002..Simvastatin did not show any unfavorable effects on HIV replication, thus could be used safely unless there are any drug interactions when administered... - Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycinKaori Asamitsu
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
J Biochem 144:581-9. 2008..When we treated the cell lines, OM10.1 and Molt4/IIIB, in which HIV-1 is latently and chronically infected, we found a strong suppressive effect of NAM on HIV-1 viral replication upon stimulation with TNF-alpha... - The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cellsKazuaki Enya
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
J Leukoc Biol 83:190-9. 2008..These results indicate that the reduction in the activity and interaction of HDAC1 with Sp1 are critical for the constitutive IL-1 alpha gene expression... - Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cellsYuka Itoh
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Biol Pharm Bull 30:1140-3. 2007..These results suggest that DHT inhibits the TNFalpha-induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease... - Induction of OGG1 gene expression by HIV-1 TatKenichi Imai
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601
J Biol Chem 280:26701-13. 2005..These findings collectively indicate the possibility that Tat may play a role in maintenance of the genetic integrity of the proviral and host cellular genomes by up-regulating OGG1 as a feed-forward mechanism... - Establishment of a simple and quantitative immunospot assay for detecting anti-type II collagen antibody using an infrared fluorescence imaging system (IFIS)Shusuke Ota
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
J Immunol Methods 299:189-98. 2005..The method and its possible applications are discussed... - RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunitKaori Asamitsu
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
J Biol Chem 278:26879-87. 2003..These data suggest that AO7 interacts with the p65 TAD and modulates its transcriptional activity... - Inhibition of human immunodeficiency virus type 1 replication in latently infected cells by a novel IkappaB kinase inhibitorAnn Florence B Victoriano
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Antimicrob Agents Chemother 50:547-55. 2006..These findings suggest that ACHP acts as a potent suppressor of TNF-alpha-induced HIV replication in latently infected cells and that this inhibition is mediated through suppression of IKK activity... - Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regionsAkira Okano
Department of Neuroplasticity, Research Center on Aging and Adaptation, University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
Brain Res 967:210-25. 2003.... - Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treated in vivo modelHiroki Urashima
Ako Research Institute, Division of Dermatologicals and Ophthalmologicals, Otsuka Pharmaceutical Co, Ltd, Hyogo 678 0207, Japan
Cornea 23:613-9. 2004..Furthermore, we attempted to evaluate the effects of rebamipide on the wound healing of N-acetylcysteine-treated eyes... - c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosisSatoshi Kanazawa
Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
Oncogene 22:5707-11. 2003..Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc... - Low pH enhances Sp1 DNA binding activity and interaction with TBPTakayuki Torigoe
Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Nucleic Acids Res 31:4523-30. 2003..These findings indicate that pH changes significantly modulate the activity of Sp1 and thus contribute to the cellular response under hypoxic or acidic conditions... - TRAF6-NF-kappaB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytesTakayuki Matsumura
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
Immunology 109:127-36. 2003.... - Involvement of RelA-associated inhibitor in regulation of trophoblast differentiation via interaction with transcriptional factor specificity protein-1Ryoko Minekawa
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
Endocrinology 148:5803-10. 2007..Taken together, these findings suggest that RAI may be involved in the regulation of trophoblast differentiation via interaction with Sp1...