Tetsuya Okajima

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
    Tetsuya Okajima
    Nagoya University Graduate School of Bioagricultural Sciences, Department of Applied Molecular Biosciences, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    BMC Biol 6:1. 2008
  2. doi request reprint O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions
    Yuta Sakaidani
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Nat Commun 2:583. 2011
  3. doi request reprint IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing beta-(1,2)-xylose and alpha-(1,3)-fucose
    Shingo Hino
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Immunol Lett 133:28-34. 2010
  4. doi request reprint Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding
    Kana Hirano
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    J Biochem 154:195-205. 2013
  5. pmc Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells
    Hajime Nakatani
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biochem 153:31-41. 2013
  6. ncbi request reprint O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors
    Aiko Matsuura
    Department of Applied Molecular Biosciences, Nagoya University Graduate School of Bioagricultural Sciences, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Biol Chem 283:35486-95. 2008
  7. doi request reprint Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers
    Takeshi Matsubara
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biochem 153:347-54. 2013
  8. doi request reprint Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis
    Tetsuya Okajima
    Nagoya University Graduate School of Bioagricultural Sciences, Department of Applied Molecular Biosciences, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Biochem 144:1-6. 2008
  9. doi request reprint Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide
    Fujio Hashizume
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya, Aichi 464 8601, Japan
    Transgenic Res 17:1117-29. 2008
  10. doi request reprint Periodate-resistant carbohydrate epitopes recognized by IgG and IgE antibodies from some of the immunized mice and patients with allergy
    Shingo Hino
    Department of Applied Molecular Biosciences, Graduate School of Bio agricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 380:632-7. 2009

Collaborators

Detail Information

Publications29

  1. pmc Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
    Tetsuya Okajima
    Nagoya University Graduate School of Bioagricultural Sciences, Department of Applied Molecular Biosciences, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    BMC Biol 6:1. 2008
    ..OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investigate the respective contributions of these activities to Notch signaling in Drosophila...
  2. doi request reprint O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions
    Yuta Sakaidani
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Nat Commun 2:583. 2011
    ..Thus, O-GlcNAcylation of secreted and membrane glycoproteins is a novel mediator of cell-cell or cell-matrix interactions at the cell surface...
  3. doi request reprint IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing beta-(1,2)-xylose and alpha-(1,3)-fucose
    Shingo Hino
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Immunol Lett 133:28-34. 2010
    ....
  4. doi request reprint Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding
    Kana Hirano
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    J Biochem 154:195-205. 2013
    ..EXP and EXT were suggested to be potentially allergenic in the rice-pollen allergy as well as the grass pollinosis. ..
  5. pmc Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells
    Hajime Nakatani
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biochem 153:31-41. 2013
    ..Taken together, these findings suggest that MFG-E8 plays a critical role in regulation of MFG dynamics after weaning or during the suckling interval through the control of MFG-epithelial cell interaction in lactating mammary glands...
  6. ncbi request reprint O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors
    Aiko Matsuura
    Department of Applied Molecular Biosciences, Nagoya University Graduate School of Bioagricultural Sciences, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Biol Chem 283:35486-95. 2008
    ..Thus, the finding of O-GlcNAc modification in extracellular environments predicts a distinct glycosylation process that might be associated with a novel regulatory mechanism for Notch receptor activity...
  7. doi request reprint Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers
    Takeshi Matsubara
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biochem 153:347-54. 2013
    ..The susceptibility of OVA to lysosomal proteases may affect its passage through the intestinal epithelia, leading to determination of allergic sensitization and elicitation in egg allergy...
  8. doi request reprint Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis
    Tetsuya Okajima
    Nagoya University Graduate School of Bioagricultural Sciences, Department of Applied Molecular Biosciences, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Biochem 144:1-6. 2008
    ..In this article, we have reviewed the recent reports addressing the distinctive features of the glycosyltransferases and O-glycans present on the EGF domains...
  9. doi request reprint Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide
    Fujio Hashizume
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya, Aichi 464 8601, Japan
    Transgenic Res 17:1117-29. 2008
    ....
  10. doi request reprint Periodate-resistant carbohydrate epitopes recognized by IgG and IgE antibodies from some of the immunized mice and patients with allergy
    Shingo Hino
    Department of Applied Molecular Biosciences, Graduate School of Bio agricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 380:632-7. 2009
    ....
  11. doi request reprint Establishment of a mammary stromal fibroblastic cell line for in vitro studies in mice of mammary adipocyte differentiation
    Hajime Nakatani
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Biol Reprod 82:44-53. 2010
    ....
  12. doi request reprint Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like
    Yoshihiko Sugihara
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Proteome Res 9:1351-66. 2010
    ..Heterogeneity of mammalian testicular ribosomes is structurally non-negligible, and may offer valuable insights into the function of the customized ribosome...
  13. ncbi request reprint Binding of Norovirus virus-like particles (VLPs) to human intestinal Caco-2 cells and the suppressive effect of pasteurized bovine colostrum on this VLP binding
    Kosuke Murakami
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan
    Biosci Biotechnol Biochem 74:541-7. 2010
    ..5 microg of the colostral proteins. Furthermore, the colostrum contained IgG antibodies reacting to VLPs, suggesting that cross-reactive antibodies in the bovine colostrums block human NoV binding to intestinal cells...
  14. ncbi request reprint Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland
    Yuki Taga
    Department of Applied Molecular Biosciences, Nagoya University, Japan
    Cell Biochem Funct 28:321-8. 2010
    ..These results suggest that early involution can be used as a model for understanding the mechanism of post-transcriptional control of gene expression, responsible for modulation of cell function...
  15. doi request reprint Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin
    Hitomi Moriya
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Arch Biochem Biophys 508:87-92. 2011
    ..Our findings suggest a new, putatively mTOR-dependent localization of the three enzymes for de novo lipogenesis...
  16. ncbi request reprint Absorption, migration and kinetics in peripheral blood of orally administered ovalbumin in a mouse model
    Takeshi Matsubara
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan
    Biosci Biotechnol Biochem 72:2555-65. 2008
    ..Such stable absorption and blood kinetics of undigested ovalbumin in normal mice suggest some sort of physiological significance for the intestinal uptake of intact food proteins...
  17. doi request reprint Glycoconjugate glycosyltransferases
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Glycoconj J 26:987-98. 2009
    ..Lastly, complex formation of glycosyltransferase proteins with related molecules including subunits, chaperones, and enzyme regulators, that have been recently reported was also summarized...
  18. ncbi request reprint Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Japan
    Biochim Biophys Acta 1573:377-81. 2002
    ..The mutations showed, respectively, 10-50% and 0% of the enzyme activity compared with wild type, suggesting that galactosytransferase I (XGal-T1) is at least one of the genes responsible for Ehlers-Danlos syndrome (progeroid variant)...
  19. ncbi request reprint [XGalT-1 involved in the synthesis of glyosaminoglycans of proteoglycans and Ehlers-Danlos syndrome (progeroid type)]
    Koichi Furukawa
    Tanpakushitsu Kakusan Koso 48:1152-7. 2003
  20. doi request reprint Discharge of solubilized and Dectin-1-reactive β-glucan from macrophage cells phagocytizing insoluble β-glucan particles: involvement of reactive oxygen species (ROS)-driven degradation
    Shingo Hino
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Chikusa ku, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 421:329-34. 2012
    ....
  21. ncbi request reprint Association of chicken zona pellucida glycoprotein (ZP) B1 with ZPC induces formation of ZPB1-ZPC fibrous aggregates containing disulfide-bridged ZPB1 dimer
    Hiroki Okumura
    Department of Applied Molecular Biosciences, Graduate School of Bio agricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 364:682-8. 2007
    ..Thus, the specific association between ZPB1 and ZPC could play pivotal roles to initiate complex formation of hetero-polymers of ZP proteins in egg-envelope matrix construction...
  22. ncbi request reprint Roles of O-fucosyltransferase 1 and O-linked fucose in notch receptor function
    Tetsuya Okajima
    Department of Applied Molecular Biosciences, Nagoya University Graduate School of Bio agricultural Sciences, Nagoya, Aichi, Japan
    Methods Enzymol 417:111-26. 2006
    ..This chapter focuses on the methods used to analyze the roles of Ofut1 in Notch receptor structure and function...
  23. pmc Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis
    Masaya Miyoshi
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochem J 404:373-81. 2007
    ..These results suggest that, while bystin may play multiple roles in mammalian cells, a conserved function is to facilitate ribosome biogenesis required for cell growth...
  24. ncbi request reprint Regulation of notch signaling by o-linked fucose
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cell 111:893-904. 2002
    ....
  25. ncbi request reprint Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Biol Chem 278:42340-5. 2003
    ..Thus, Notch-ligand interactions are dependent upon both the presence and the type of O-fucose glycans...
  26. ncbi request reprint Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 307:1599-603. 2005
    ..This ability of OFUT1 to facilitate folding of Notch did not require its fucosyltransferase activity. Thus, a glycosyltransferase can bind its substrate in the endoplasmic reticulum to facilitate normal folding...
  27. ncbi request reprint Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis
    Yoko Nakamura
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 277:46280-8. 2002
    ..Our results demonstrate that Drosophila beta4GalT7 has the in vitro and in vivo properties predicted for an ortholog of human beta4GalT7 and is essential for normal animal development through its role in proteoglycan biosynthesis...
  28. ncbi request reprint Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides
    Akiko Tsuchida
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 0065, Japan
    J Biol Chem 278:22787-94. 2003
    ..None of them expressed ST6GalNAc V. These results suggested the novel substrate specificity of ST6GalNAc VI, which is responsible for the synthesis of disialyl Lea but not for alpha-series gangliosides in human colon tissues...
  29. doi request reprint Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains
    Yuko Chigira
    Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1, Higashi, Tsukuba, Ibaraki
    Glycobiology 18:303-14. 2008
    ..Such proteins can be used for the analysis of substrate specificity and the production of antibodies that recognize O-glycosylated EGF domains...