K Ohno


Affiliation: Nagoya University
Country: Japan


  1. Li J, Ito M, Ohkawara B, Masuda A, Ohno K. Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction. Sci Rep. 2018;8:13577 pubmed publisher
  2. Azuma Y, Nakata T, Tanaka M, Shen X, Ito M, Iwata S, et al. Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits. Neuromuscul Disord. 2015;25:60-9 pubmed publisher
    ..Met465Thr was 5.1% in the Japanese population. Lack of shared mutant alleles between the Japanese and the other patients suggests that most mutations described here are ethnically unique or de novo in each family. ..
  3. Tsunoda M, Hirayama M, Tsuda T, Ohno K. Noninvasive monitoring of plasma L-dopa concentrations using sweat samples in Parkinson's disease. Clin Chim Acta. 2015;442:52-5 pubmed publisher
    ..The deviations may also be partly accounted for by skin permeability of L-dopa. Measuring L-dopa concentrations in sweat is suitable to get further insights into the L-dopa metabolism. ..
  4. Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, et al. A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space. Neuromuscul Disord. 2015;25:667-71 pubmed publisher
    ..As five of the seven missense mutations in SJS affect domain III of perlecan, domain III is likely to be essential for secretion of perlecan into the extracellular space. ..
  5. Ohno K, Ito M, Ichihara M, Ito M. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev. 2012;2012:353152 pubmed publisher
    ..Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease. ..
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    Ohno K, Ito M, Masuda A. [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2009;29:145-51 pubmed
    ..We need to further pursue the molecular bases and the therapeutic strategies of defective neuromuscular transmissions, and hopefully expand our analysis to defective synapse transmissions in the central nervous system. ..
  7. Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, et al. Position-specific binding of FUS to nascent RNA regulates mRNA length. Genes Dev. 2015;29:1045-57 pubmed publisher
  8. Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, et al. Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters. Biochem Biophys Res Commun. 2016;470:356-361 pubmed publisher
    ..Tranilast is a potential agent that accelerates fracture repair by promoting the regulatory steps of endochondral ossification. ..
  9. Ohno K, Otsuka K, Ito M. Roles of collagen Q in MuSK antibody-positive myasthenia gravis. Chem Biol Interact. 2016;259:266-270 pubmed publisher
    ..We propose that attenuation of AChR clustering in MuSK-MG is due to hindrance of LRP4-MuSK interaction in the presence of agrin by MuSK-IgG. ..

More Information


  1. Ito K, Ohkawara B, Yagi H, Nakashima H, Tsushima M, Ota K, et al. Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters. Sci Rep. 2018;8:434 pubmed publisher
    ..In C2C12 myotubes, FGF18 enhanced AChR clustering, which was blocked by inhibiting FGFRs or MEK1. We propose that FGF18 plays a pivotal role in AChR clustering and NMJ formation in mouse embryogenesis. ..
  2. Ohno K, Tsujino A, Shen X, Milone M, Engel A. Spectrum of splicing errors caused by CHRNE mutations affecting introns and intron/exon boundaries. J Med Genet. 2005;42:e53 pubmed
    ..Only three of the eight intronic splice site mutations of CHRNE reported to date have had their splicing consequences characterised...
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    Ohno K, Engel A. Splicing abnormalities in congenital myasthenic syndromes. Acta Myol. 2005;24:50-4 pubmed
    ..Splicing mutations may be more frequent than suspected, and one must always be aware of possible splicing abnormalities when analyzing human mutations...
  4. Asai N, Ohkawara B, Ito M, Masuda A, Ishiguro N, Ohno K. LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation. Biochem Biophys Res Commun. 2014;451:302-7 pubmed publisher
  5. Gao K, Wang J, Li L, Zhai Y, Ren Y, You H, et al. Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province. ..
  6. Takegami Y, Ohkawara B, Ito M, Masuda A, Nakashima H, Ishiguro N, et al. R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification. Biochem Biophys Res Commun. 2016;473:255-264 pubmed publisher
    ..We propose that Rspo2 activates Wnt/β-catenin signaling to reduce Col2a1 and Sox9 and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage. ..
  7. Takeda J, Masuda A, Ohno K. Six GU-rich (6GUR) FUS-binding motifs detected by normalization of CLIP-seq by Nascent-seq. Gene. 2017;618:57-64 pubmed publisher
    ..We propose that the 6GUR motifs predict FUS-binding sites more efficiently than previously reported individual motifs or 15 motifs in SpliceAid 2. ..