K Ogawa

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint Malignant solitary fibrous tumor of the meninges
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Japan
    Virchows Arch 444:459-64. 2004
  2. ncbi request reprint Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Cancer Lett 236:32-8. 2006
  3. ncbi request reprint Reactive angioendotheliomatosis of the intestine
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Am J Surg Pathol 28:257-61. 2004
  4. ncbi request reprint Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis
    K Ogawa
    First Department of Pathology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Nutr Cancer 40:134-9. 2001
  5. ncbi request reprint Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Japan
    Med Mol Morphol 38:23-9. 2005
  6. ncbi request reprint Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice
    K Ogawa
    First Department of Pathology, Nagoya City University, Medical School, 1 Kawasumi, Mizuho cho, Nagoya 467 8601, Japan
    Int J Cancer 91:797-802. 2001
  7. ncbi request reprint Aberrant expression of p27(Kip1) is associated with malignant transformation of the rat urinary bladder epithelium
    K Ogawa
    First Department of Pathology, Nagoya City University, Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 21:117-21. 2000
  8. ncbi request reprint Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys
    K Ogawa
    Nagoya City University Medical School
    Jpn J Cancer Res 90:622-8. 1999
  9. ncbi request reprint Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model
    K Ogawa
    First Department of Pathology, Nagoya City University Medical School, Japan
    Int J Cancer 76:851-6. 1998
  10. ncbi request reprint Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure
    K Imaida
    1st Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Cancer Lett 155:105-14. 2000

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Malignant solitary fibrous tumor of the meninges
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Japan
    Virchows Arch 444:459-64. 2004
    ..1+/-6.4% and 6/10HPF in the last (5th) one, respectively. Thus, the present case suggests that meningeal SFTs possess malignant potential so that careful long-term follow up is required...
  2. ncbi request reprint Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Cancer Lett 236:32-8. 2006
    ....
  3. ncbi request reprint Reactive angioendotheliomatosis of the intestine
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Am J Surg Pathol 28:257-61. 2004
    ..The present case might thus be a first case of RAE of the intestine without cutaneous involvement. Whether there is a relation with coexistent enteritis suggestive of Crohn's disease needs to be clarified...
  4. ncbi request reprint Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis
    K Ogawa
    First Department of Pathology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Nutr Cancer 40:134-9. 2001
    ..From the present experiment, we can conclude that > 0.01% PEITC enhances rat urinary bladder carcinogenesis, while weakly promoting hepatocarcinogenesis. In addition, it is suggested that > 0.05% PEITC has tumorigenic potential...
  5. ncbi request reprint Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Japan
    Med Mol Morphol 38:23-9. 2005
    ..The results indicate that rat liver preneoplastic lesions might be protected against apoptosis and that the approach adopted is useful for clarification of mechanisms underlying hepatocarcinogenesis...
  6. ncbi request reprint Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice
    K Ogawa
    First Department of Pathology, Nagoya City University, Medical School, 1 Kawasumi, Mizuho cho, Nagoya 467 8601, Japan
    Int J Cancer 91:797-802. 2001
    ..A point mutation in the GSK-3beta phosphorylation site of the beta-catenin gene was found in L2. These transplantable HCC cell lines that have different metastatic ability should be useful for elucidation of mechanisms of metastasis...
  7. ncbi request reprint Aberrant expression of p27(Kip1) is associated with malignant transformation of the rat urinary bladder epithelium
    K Ogawa
    First Department of Pathology, Nagoya City University, Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 21:117-21. 2000
    ..In irreversible tumorous bladder lesions, on the other hand, persistent low expression of p27(Kip1) and elevated cyclin D1 and cyclin E are characteristic...
  8. ncbi request reprint Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys
    K Ogawa
    Nagoya City University Medical School
    Jpn J Cancer Res 90:622-8. 1999
    ....
  9. ncbi request reprint Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model
    K Ogawa
    First Department of Pathology, Nagoya City University Medical School, Japan
    Int J Cancer 76:851-6. 1998
    ....
  10. ncbi request reprint Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure
    K Imaida
    1st Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Cancer Lett 155:105-14. 2000
    ....
  11. ncbi request reprint Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model
    M Futakuchi
    First Department of Pathology, Nagoya City University Medical School, Nagoya
    Jpn J Cancer Res 90:1196-202. 1999
    ..This model, with its essential similarities to malignant tumor behavior in man, should find application not only for elucidation of the mechanisms underlying metastasis, but also in the development of anti-metastatic agents...
  12. ncbi request reprint Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP)
    K Imaida
    1st Department of Pathology, Nagoya City University Medical School, Japan
    Cancer Lett 150:63-9. 2000
    ....
  13. ncbi request reprint Organ dependent enhancement of rat 3,2'-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate
    K Imaida
    First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 22:1295-9. 2001
    ..Taking into account previous data, that PhIP clearly enhanced rat 1,2-dimethylhydrazine-initiated colon tumorigenesis, the potential of PhIP to enhance colon carcinogenesis may be initiator dependent...
  14. ncbi request reprint Histomorphological characteristics of cholangiocellular carcinomas in northeast Thailand, where a region infection with the liver fluke, Opisthorchis viverrini is endemic
    T Shirai
    First Department of Pathology, Nagoya, City University, Medical School, Japan
    Acta Pathol Jpn 42:734-9. 1992
    ....
  15. doi request reprint Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice
    D Zhang
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Oncogene 27:4305-14. 2008
    ..Both p53 and p16 are critical in preventing mammary gland tumorigenesis in the Aurora A overexpression mouse model...
  16. ncbi request reprint [Gallbladder metastasis of large cell lung cancer]
    T Tanaka
    Department of Surgery, East Medical Center Higashi Municipal Hospital City of Nagoya, Nagoya, Japan
    Kyobu Geka 62:1069-72. 2009
    ..By reevaluation of pathology of the gallbladder, the tumor was found to have similar component of resected lung cancer, suggesting the possibility of the tumor to be metastatic...
  17. pmc Expression of granulysin in polymyositis and inclusion-body myositis
    K Ikezoe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Neurosurg Psychiatry 77:1187-90. 2006
    ....
  18. ncbi request reprint Purification and characterization of a new tissue inhibitor of metalloproteinases (TIMP-2) from mouse colon 26 tumor cells
    J Kishi
    Department of Biochemistry, School of Dentistry, Aichi Gakuin University, Nagoya, Japan
    Matrix 11:10-6. 1991
    ..NH2-Terminal protein sequence data were obtained for the first 36 residues of the colon 26 inhibitor, and the first 20 of them exhibited a sequence almost identical with that of a new TIMP recently designated as TIMP-2...
  19. ncbi request reprint Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine
    Hiroko Yoshino
    DIMS, Daiyu kai Institute of Medical Sciences, Nishiazai, Azai cho, Ichinomiya, Japan
    Clin Exp Metastasis 22:441-7. 2005
    ..Thus, it can be said that this system is a more appropriate model for elucidation of mechanisms of metastasis and also for analysis of factors to inhibit natural metastasis...
  20. ncbi request reprint Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences
    Masanori Kuribayashi
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Lett 232:289-99. 2006
    ..The results suggest that suppression of syndecan-2 (Sdc2) and induction of cell cycle arrest through a p21-dependent pathway might have counter-acted any promotion effects of up-regulation of CYP1A2...
  21. ncbi request reprint Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat
    Naomi Hokaiwado
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Toxicol Pathol 33:695-701. 2005
    ....
  22. ncbi request reprint Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells
    Kazunari Tsujimura
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, 1 Kawasumi, Nagoya, Japan
    Cancer Sci 97:1002-10. 2006
    ..Using nine external samples, correct prediction of carcinogenicity by SVM was 88.9%. These results indicate that short-term bioassay systems for carcinogenicity using gene expression profiling in hepatoma cells have great promise...
  23. ncbi request reprint Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells
    Mingxi Tang
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 98:471-7. 2007
    ..In conclusion, these compounds, particularly nobiletin, may be valuable for prostate cancer prevention...
  24. ncbi request reprint Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication
    Naomi Hokaiwado
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, Japan
    J Membr Biol 218:101-6. 2007
    ..Thus, normal function of Cx32 may be essential for suppression of both early and late stages of hepatocarcinogenesis...
  25. ncbi request reprint Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation
    Atsuya Hikosaka
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Nagoya 467 8601, Japan
    Int J Cancer 122:1222-8. 2008
    ..These findings suggest that p27 deficient mice have elevated susceptibility to BBN-induction of urinary bladder carcinogenesis through a mechanism which might be independent of acceleration of cell cycling...
  26. ncbi request reprint Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    Cancer Res 67:11353-8. 2007
    ..Thus, these data suggested that GPX2 may be involved in mammary carcinogenesis and cell proliferation in both rats and humans, indicating that GPX2 may be a novel target for the prevention and therapy of breast cancer...
  27. doi request reprint Transforming growth factor beta derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment
    Shinya Sato
    Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467 8601, Japan
    Cancer Sci 99:316-23. 2008
    ..Thus, we experimentally show that TGFbeta derived from bone matrix promotes cell proliferation of rat prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment...
  28. ncbi request reprint Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist
    Mahmoud M Said
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467 8601, Japan
    Cancer Sci 97:459-67. 2006
    ....
  29. ncbi request reprint Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, on prostate and colon lesion development in F344 rats
    Yoshihisa Ikeda
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Lett 224:23-30. 2005
    ..The present findings indicate that PhIP exposure via placenta and breast milk may be important but that high doses and long periods may be necessary for tumor development...
  30. ncbi request reprint Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats
    Mitsuru Futakuchi
    First Department of Pathology, Nagoya City University, Medical School, 1 Kawasomi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 23:283-7. 2002
    ..The observed inhibition may largely be due to interference with PhIP-DNA adduct formation. In addition, HTHQ has been demonstrated to inhibit duodenal carcinogenesis in the post-initiation stage...
  31. ncbi request reprint Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma
    Mitsuru Futakuchi
    Department of Experimental Pathology, Graduate School of Medical Science, Nagoya City University, and Nagoya shi Kohseiin Geriatric Hospital, Nagoya, Japan
    Jpn J Cancer Res 93:1175-81. 2002
    ..Moreover, these data indicate this in vivo model for induction of rat highly metastatic HCC to be a useful tool for the assessment of the efficacy of therapeutic treatments to block metastasis formation...
  32. ncbi request reprint Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate
    Satoshi Sugiura
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 24:547-53. 2003
    ....
  33. ncbi request reprint Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats
    Atsushi Kuno
    First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Aichi, Japan
    Gastroenterology 124:1010-9. 2003
    ..We assessed the effects of lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, on spontaneously occurring chronic pancreatitis...
  34. ncbi request reprint Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors
    Jinglei Cheng
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Cancer Lett 193:17-24. 2003
    ..These observations demonstrated for the first time that increased intake of n-3 PUFAs promotes apoptosis of normal colon mucosa in human which is related to effect on Bax or the balance of Bax and Bcl-2...
  35. ncbi request reprint Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    Fumitaka Takeshita
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Lett 194:25-35. 2003
    ..In conclusion, only increased level of DNA adducts in the colon partially related to the modifying effects of caffeine on PhIP-induced rat carcinogenesis. Thus, other unknown factors must be contributory...
  36. ncbi request reprint Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats
    Keisuke Akagi
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Toxicol Pathol 31:388-96. 2003
    ..In addition, hydrophobic activity of ITCs, dependent on the alkyl carbon chain length, might strongly influence the induction of bladder lesions in rats...
  37. ncbi request reprint Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats
    Tamaki Yamada
    Department of Comprehensive Medicine, Internal Medicine, and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
    J Pharmacol Exp Ther 307:17-23. 2003
    ..We propose that angiotensin II receptor type 1 antagonists may be useful for the treatment of chronic pancreatitis involving angiotensin II interaction with its receptor...
  38. ncbi request reprint Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma
    Mitsuru Futakuchi
    Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 95:18-24. 2004
    ..Its mechanism of action may involve suppression of VCAM-1 and VEGF-A188 production...
  39. ncbi request reprint Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo
    Hiroyuki Ohnishi
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Cancer Sci 95:936-42. 2004
    ..These results suggest that phytochemicals might have chemopreventive potential in late stages of hepatocarcinogenesis...
  40. ncbi request reprint Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats
    Tamaki Yamada
    Okazaki City Medical Association, Public Health Center, 1 9 1 Tatsumi nishi, Okazaki, Aichi, Japan, 444 0875
    J Pharmacol Exp Ther 313:36-45. 2005
    ..Compared with the either therapy alone, combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II type 1 receptor blocker may be more beneficial for treating chronic pancreatitis...
  41. ncbi request reprint FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration
    Tetsu Okamoto
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Pancreas 30:e64-70. 2005
    ..To assess the effects of FTY720 on the development of pancreatic inflammation and fibrosis in the same model, the agent dissolved in physiologic saline was subcutaneously injected to 10-week-old male WBN/Kob rats for 10 weeks...
  42. ncbi request reprint Lack of carcinogenicity of silicone resin (KS66) in F344 rats
    Mayumi Kawabe
    Research Division, DIMS Institute of Medical Science, Inc, 64 Goura, Nishiazai, Azai cho, Ichinomiya 491 0113, Japan
    Food Chem Toxicol 43:1065-71. 2005
    ..Detailed histopathological examination revealed no treatment-related increase in the incidences of any non-neoplastic or neoplastic lesions. The results demonstrate that KS66 is not carcinogenic in F344 rats of either sex...
  43. ncbi request reprint Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats
    Hitoshi Kandori
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 96:221-6. 2005
    ..Our results indicate that the observed atrazine-related suppression of prostate carcinogenesis was probably caused by the decrease in calorie intake, rather than by atrazine-related endocrine disruption...
  44. ncbi request reprint Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes
    Kumiko Ogawa
    Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Epilepsy Res 71:76-87. 2006
    ..Thus, the increased erythrocyte distribution of VPA by CPs observed under in vivo conditions may partly be explained by their interaction with Mrps in erythrocyte membranes...
  45. ncbi request reprint Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats
    Jing Lei Cheng
    Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Science, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Lett 196:161-8. 2003
    ..These results suggest that a diet containing appropriate levels of CFA-S may be useful for prevention of mammary and colon cancer...
  46. ncbi request reprint A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats
    Kyoko Nabae
    DIMS Institute of Medical Science, Inc, 64 Goura, Nishiazai, Azai cho, Ichinomiya 491 0113, Japan
    Food Chem Toxicol 46:774-80. 2008
    ..Thus, the No-observed-adverse-effect-level (NOAEL) was judged to be 5.0% in diet for both sexes (male: 3542 mg/kg/day, female: 3849 mg/kg/day) for PCC under the present experimental conditions...
  47. ncbi request reprint Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats
    Norio Imai
    DIMS Institute of Medical Science, Inc, Nishiazai, Ichinomiya, Japan
    J Toxicol Sci 31:357-70. 2006
    ..Detailed histopathological examination revealed no treatment-related increase in the incidences of any neoplastic lesions. The results demonstrate that hinokitiol is not carcinogenic in F344 rats of either sex...
  48. ncbi request reprint Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats
    Tomoharu Yokooji
    Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Pharm Pharmacol 57:579-85. 2005
    ....