T Naoe

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Gene mutations of acute myeloid leukemia in the genome era
    Tomoki Naoe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 97:165-74. 2013
  2. pmc Identification of non-coding RNAs embracing microRNA-143/145 cluster
    Akio Iio
    Department of Medical Oncology, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Mol Cancer 9:136. 2010
  3. ncbi request reprint Developing target therapy against oncogenic tyrosine kinase in myeloid maliganacies
    Tomoki Naoe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Curr Pharm Biotechnol 7:331-7. 2006
  4. ncbi request reprint Mechanism-based therapy for leukemia: a lesson from ATRA therapy
    T Naoe
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Japan
    Nagoya J Med Sci 64:103-8. 2001
  5. ncbi request reprint FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy
    T Naoe
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Cancer Chemother Pharmacol 48:S27-30. 2001
  6. ncbi request reprint Normal and oncogenic FLT3
    T Naoe
    Department of Hematology, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cell Mol Life Sci 61:2932-8. 2004
  7. ncbi request reprint Nucleophosmin: a versatile molecule associated with hematological malignancies
    Tomoki Naoe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 97:963-9. 2006
  8. ncbi request reprint Leukemia relapse reconsidered from the molecular aspect
    T Naoe
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya 466 8560, Japan
    Leuk Lymphoma 37:527-34. 2000
  9. ncbi request reprint Significance of additional high-dose cytarabine in combination with cyclophosphamide plus total body irradiation regimen for allogeneic stem cell transplantation
    Y Inamoto
    Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Bone Marrow Transplant 39:25-30. 2007
  10. ncbi request reprint Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors
    Y Minami
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Leukemia 16:1535-40. 2002

Collaborators

Detail Information

Publications130 found, 100 shown here

  1. ncbi request reprint Gene mutations of acute myeloid leukemia in the genome era
    Tomoki Naoe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 97:165-74. 2013
    ..Comprehensive genome research will deepen the understanding of AML to promote the development of new classification and treatment. This review focuses on gene mutations that were recently discovered by genome sequencing...
  2. pmc Identification of non-coding RNAs embracing microRNA-143/145 cluster
    Akio Iio
    Department of Medical Oncology, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Mol Cancer 9:136. 2010
    ....
  3. ncbi request reprint Developing target therapy against oncogenic tyrosine kinase in myeloid maliganacies
    Tomoki Naoe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Curr Pharm Biotechnol 7:331-7. 2006
    ..Challenging studies with TKIs have also been reported for acute myeloid leukemia. This review will focus on recent trials of TKIs against oncogenic tyrosine kinases (ABL, PDGFRs, FLT3 and KIT) in myeloid malignancies...
  4. ncbi request reprint Mechanism-based therapy for leukemia: a lesson from ATRA therapy
    T Naoe
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Japan
    Nagoya J Med Sci 64:103-8. 2001
    ..Basic and clinical research into ATRA-resistance provides new directions for acute myeloid leukemia therapy. Anti-leukemia therapy will continue to lead the field of chemotherapy in the coming decades...
  5. ncbi request reprint FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy
    T Naoe
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Cancer Chemother Pharmacol 48:S27-30. 2001
    ..Another HSP90 inhibitor, radicicol, also induced apoptosis selectively in transformed 32D cells. HSP90 is a promising target for the treatment of AML with mutant FLT3...
  6. ncbi request reprint Normal and oncogenic FLT3
    T Naoe
    Department of Hematology, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cell Mol Life Sci 61:2932-8. 2004
    ..Exploring the mechanism by which FLT3 mutations cause autoactivation and uncontrolled signaling might lead to a better understanding of how FLT3 becomes oncogenic and provide insights for the development of new drugs...
  7. ncbi request reprint Nucleophosmin: a versatile molecule associated with hematological malignancies
    Tomoki Naoe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 97:963-9. 2006
    ..This review focuses on the clinical significance of the NPM1 gene in hematological malignancies and newly discovered roles of NPM associated with oncogenesis...
  8. ncbi request reprint Leukemia relapse reconsidered from the molecular aspect
    T Naoe
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya 466 8560, Japan
    Leuk Lymphoma 37:527-34. 2000
    ..Studies on leukemia relapse have thus served as a model of clonal progression, which can be serially observed, including selection by chemotherapy, induction of resistant phenotype, and genetic alteration...
  9. ncbi request reprint Significance of additional high-dose cytarabine in combination with cyclophosphamide plus total body irradiation regimen for allogeneic stem cell transplantation
    Y Inamoto
    Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Bone Marrow Transplant 39:25-30. 2007
    ..In summary, addition of HDCA is not beneficial for high-risk patients, and is not recommended for standard-risk patients receiving unrelated transplantation...
  10. ncbi request reprint Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors
    Y Minami
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Leukemia 16:1535-40. 2002
    ..These findings imply that targeting of Hsp90 will facilitate the development of anti-TDFLT3 therapy, and that Hsp90 is closely involved in the oncogenic activation of FLT3...
  11. ncbi request reprint Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD
    M Okamoto
    1Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leukemia 21:403-10. 2007
    ..These results demonstrate that Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD...
  12. ncbi request reprint In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD / Shi-scid/scid mice
    H Kosugi
    First Department of Internal Medicine, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8560, Japan
    Jpn J Cancer Res 92:529-36. 2001
    ..These findings suggest that FK228 is a promising agent to enhance ATRA-sensitivity in the treatment of APL...
  13. ncbi request reprint Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients
    S Terakura
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Bone Marrow Transplant 37:381-6. 2006
    ..These results suggest that a GSTM1-null genotype in recipients protects against TRM after allogeneic HSCT. Further studies are needed to elucidate a mechanism of increased risk for TRM in GSTM1-positive recipients...
  14. ncbi request reprint Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    Y Yamamoto
    Department of Infectious Diseases and the First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Blood 97:2434-9. 2001
    ..These results demonstrate that the FLT3 gene is the target most frequently mutated to become constitutively active in AML...
  15. ncbi request reprint Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy
    T Naoe
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Leukemia 16:203-8. 2002
    ..073; within 120 days, P = 0.028), whereas CR rates and relapse frequencies were similar. The null genotype of GSTT1 might be associated with increased toxicity after chemotherapy...
  16. ncbi request reprint TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways
    T Kanie
    Department of Hematology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Leukemia 18:548-55. 2004
    ..These data suggest that TEL-Syk fusion protein in the cytoplasm leads to the constitutive activation of PI3-K/Akt, MAPK and STAT5 signal pathways, which are closely involved in IL-3-independent cell proliferation of BaF3 cells...
  17. ncbi request reprint Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: significant roles of total body irradiation and chronic graft-versus-host disease
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Bone Marrow Transplant 36:867-72. 2005
    ..Thus, patients who developed extensive chronic GVHD had better survivals (P = 0.0217), and those who developed grade III-IV acute GVHD had worse survivals (P = 0.0023) than did the others...
  18. ncbi request reprint Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation
    Y Atsuta
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Japan
    Bone Marrow Transplant 37:289-96. 2006
    ..Our patients could not be accurately classified when the proposed prognostic models from Western countries were used, thus indicating the need for a different model to identify high-risk patients...
  19. doi request reprint Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic SCT
    M Murase
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Bone Marrow Transplant 46:1444-9. 2011
    ..As the presence of the C-A-A haplotype reduced relapse risk and improved survival after allogeneic HSCT, this CTLA-4 haplotype may provide useful information for donor selection...
  20. ncbi request reprint Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice
    M Ninomiya
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Japan
    Leukemia 21:136-42. 2007
    ..These findings suggest that xenotransplantation into immunodeficient mice provides a useful model to study the leukemia niche...
  21. doi request reprint Clinicopathological manifestations and treatment of intestinal transplant-associated microangiopathy
    Y Inamoto
    Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya 466 8560, Japan
    Bone Marrow Transplant 44:43-9. 2009
    ..Avoiding intensified immunosuppression that damages vascular endothelium until the resolution of i-TAM may improve transplant outcome...
  22. ncbi request reprint Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells
    M Murata
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Jpn J Cancer Res 91:1154-60. 2000
    ..This novel agent might be useful in the treatment of lymphoid malignancies, because the above concentrations are clinically achievable in vivo according to a recent clinical study...
  23. doi request reprint A prospective dose-finding trial using a modified continual reassessment method for optimization of fludarabine plus melphalan conditioning for marrow transplantation from unrelated donors in patients with hematopoietic malignancies
    S Terakura
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Japan
    Ann Oncol 22:1865-71. 2011
    ..Thus we examined that modified continual reassessment method (mCRM) is applicable for deciding appropriate conditioning of allogeneic BM transplantation...
  24. doi request reprint BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4
    Momoko Suzuki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Eur J Haematol 84:229-38. 2010
    ..We investigated the mechanism responsible for imatinib (IM) resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) cell lines...
  25. ncbi request reprint Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis
    K Shimada
    Nagoya Blood and Marrow Transplantation Group NBMTG, Nagoya, Japan
    Bone Marrow Transplant 36:115-21. 2005
    ..8%. Our data suggest that early detection of secondary cancers is very important in prolonging overall survival...
  26. ncbi request reprint Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leukemia 19:1345-9. 2005
    ..Although it should be borne in mind that this meta-analysis was based on data abstracted from observational studies, these results may justify the risk-adapted therapeutic strategies for AML according to the FLT3 status...
  27. doi request reprint Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD
    Y Inamoto
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 45:363-9. 2010
    ..In conclusion, more active homing of CCR9-926AG T cells to Peyer's patches may produce changes in Ag presentation and result in increased incidence of skin GVHD...
  28. doi request reprint p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation
    A Furuhata
    Nagoya University Graduate School of Medicine, Nagoya University School of Health Sciences, Nagoya, Japan
    Biochem Biophys Res Commun 383:411-6. 2009
    ..Similar findings were observed in BCR/ABL-transfected Ba/F3. Our results elucidate the regulatory mechanism by which JAK2V617F modulates Skp2 gene expression through the STAT transcription factors...
  29. doi request reprint L1503R is a member of group I mutation and has dominant-negative effect on secretion of full-length VWF multimers: an analysis of two patients with type 2A von Willebrand disease
    T Kashiwagi
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haemophilia 14:556-63. 2008
    ..Protein instability of L1503R may be responsible for its intracellular retention and perhaps the larger VWF multimers, containing more mutant VWF subunits, are likely to be mal-processed and retained within the cell...
  30. doi request reprint Prospective monitoring of BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia undergoing imatinib-combined chemotherapy
    Masamitsu Yanada
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 143:503-10. 2008
    ....
  31. doi request reprint Prognostic implication and biological roles of RhoH in acute myeloid leukaemia
    Toshihiro Iwasaki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 81:454-60. 2008
    ..e. high GTP-Rac) contributes to chemotherapy resistance in leukaemia cells. Our result suggests that inhibition of Rac and its signalling components might provide a useful anti-leukaemic strategy...
  32. ncbi request reprint Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome
    M Iwai
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leukemia 19:1367-75. 2005
    ..These results suggested that FHIT methylation was accumulated through the disease progression of MDS and AML, and the role of the FHIT gene as a tumor suppressor seemed different in AML and MDS...
  33. ncbi request reprint In vitro characterization of missense mutations associated with quantitative protein S deficiency
    H Okada
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Thromb Haemost 4:2003-9. 2006
    ..To elucidate the molecular consequences of hereditary protein S (PS) deficiency, we investigated the in vitro synthesis of the PS missense mutants in COS-1 cells and their activated protein C (APC) cofactor activities...
  34. ncbi request reprint Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1
    T Kajiguchi
    The First Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leukemia 17:2189-95. 2003
    ..This finding may provide a basis to select a subgroup other than acute promyelocytic leukemia, which can benefit from As(2)O(3) treatment...
  35. doi request reprint Skewed X chromosome inactivation in fraternal female twins results in moderately severe and mild haemophilia B
    K Okumura
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haemophilia 14:1088-93. 2008
    ..This crossing-over was absent in the other twin, consistent with their fraternal state. Differently skewed X inactivation in the fraternal female twins might cause moderately severe and mild haemophilia B phenotypes, respectively...
  36. ncbi request reprint Tacrolimus instead of cyclosporine used for prophylaxis against graft-versus-host disease improves outcome after hematopoietic stem cell transplantation from unrelated donors, but not from HLA-identical sibling donors: a nationwide survey conducted in Jap
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 34:331-7. 2004
    ..62, 95% CI: 1.23-2.14, P=0.0007 for OS). This superiority of FK506 was not observed in SIB-HSCT cases. These findings indicate that the use of FK506 instead of CSP for GVHD prophylaxis is beneficial for patients undergoing UD-HSCT...
  37. ncbi request reprint Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia
    Masayuki Towatari
    Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Blood 104:3507-12. 2004
    ..This is especially useful because it provides the patients with a better chance to receive an allogeneic HSC transplant...
  38. ncbi request reprint Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo
    Akihide Atsumi
    Department of Hematology, Nagoya University Graduate School of Medicine, Showa Ku, Japan
    Biochem Biophys Res Commun 345:1471-80. 2006
    ..These results provide evidence to show that the N-CoR/HDAC3 co-repressor complex is involved in the aberrant transcription regulation in PML-RARalpha-expressing cells...
  39. ncbi request reprint Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation
    Kouichi Watamoto
    Department of Molecular Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466 8550, Japan
    Oncogene 22:9176-84. 2003
    ..These observations support the suggestion that control of the HDAC5 nucleocytoplasmic distribution might be associated with MEL cell differentiation, possibly through regulated GATA-1 transactivation...
  40. ncbi request reprint A UGT2B17-positive donor is a risk factor for higher transplant-related mortality and lower survival after bone marrow transplantation
    Seitaro Terakura
    Department of Haematology, Nagoya University Graduate School of Medicine, Aichi, Japan
    Br J Haematol 129:221-8. 2005
    ..Thus, the enzyme function of UGT2B17 in donor cells may affect the outcome of allogeneic HSCT...
  41. ncbi request reprint BMI-1 is highly expressed in M0-subtype acute myeloid leukemia
    Masashi Sawa
    Department of Molecular Medicine and Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 82:42-7. 2005
    ..These results indicated that a subgroup of M0 patients has a high expression level of polycomb group gene BMI-1, which may contribute to leukemogenesis...
  42. doi request reprint Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy
    Masamitsu Yanada
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haematologica 93:287-90. 2008
    ..027), and increase the risk of treatment failure by 2.8-fold...
  43. ncbi request reprint High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia
    H Narimatsu
    Department of Hematology and Oncology, JA Aichi Showa Hospital, Konan, Japan
    Bone Marrow Transplant 40:773-8. 2007
    ..The unexpectedly high prevalence and the characteristics of SFPR may provide additional information on management following autologous SCT for acute myeloid leukemia...
  44. doi request reprint Clinical characteristics of chronic graft-versus-host disease following umbilical cord blood transplantation for adults
    K Sugimoto
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 41:729-36. 2008
    ..047). These results suggest that chronic GVHD following CBT is mild and has a graft-versus-malignancy effect...
  45. doi request reprint PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML
    S Kurahashi
    Department of Hematology and Oncology, Nagoya University, Graduate School of Medicine, Nagoya, Aichi, Japan
    Oncogene 30:1822-30. 2011
    ..These data suggest the possible involvement of this fusion protein in the leukemogenesis of B-ALL in a dual dominant-negative manner and the possibility that ALL with PAX5-PML can be treated with ATO...
  46. ncbi request reprint Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR-ABL-positive acute lymphoblastic leukemia
    S Mizuta
    Department of Hematology, Fujita Health University Hospital, Toyoake, Aichi, Japan
    Leukemia 25:41-7. 2011
    ..265). Imatinib-based therapy is a potentially useful strategy for newly diagnosed patients with Ph+ALL, not only providing them more chance to receive allo-HSCT, but also improving the outcome of allo-HSCT...
  47. ncbi request reprint Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line
    M Ninomiya
    Department of Hematology, Nagoya University Hospital, Nagoya, Japan
    Leukemia 18:442-8. 2004
    ..These findings suggested that the activation of adhesion molecules for leukocytes and expression of CXC chemokines in the lung are closely involved in triggering RAS...
  48. doi request reprint Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan Adult Leukemia Study Group
    Yasuyoshi Morita
    Department of Hematology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Int J Hematol 91:97-103. 2010
    ..In conclusion, it is necessary to introduce the first line therapy excluding the chemotherapy that can prolong survival in patients with high-risk MDS and MDS-AML...
  49. ncbi request reprint Escape mechanisms from antibody therapy to lymphoma cells: downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation
    Takumi Sugimoto
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 390:48-53. 2009
    ..These results suggest that recruitment of the Sin3A-HDAC1 complex is related to downregulation of CD20 expression in CD20-negative B-cells after treatment with rituximab...
  50. ncbi request reprint Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia
    Kazutaka Ozeki
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Blood 103:1901-8. 2004
    ..These results indicated that FLT3 overexpression may distinguish a novel disease entity in AML without FLT3 mutations and serve as a therapeutic target for FLT3 inhibitors...
  51. doi request reprint Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib
    H Mizuno
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leukemia 26:2269-76. 2012
    ..These results provide further evidence supporting causal relationships between inflammation and tumor growth, and demonstrate that bortezomib can target the tumor microenvironment...
  52. ncbi request reprint Allogeneic myeloablative transplantation for patients aged 50 years and over
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 34:29-35. 2004
    ..0303, respectively). These findings indicate that allogeneic c-HSCT should be offered to patients over 50 years only if the increased risk of TRM is acceptable, and that a non-TBI regimen is preferable when the transplant is performed...
  53. pmc B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells
    Y Hirose
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Immunology 104:410-7. 2001
    ..These results indicated that immature features of pre-B cells from CB, such as lack of TdT expression, and a short N region and few productive rearrangements in the IgH gene, might cause the delay in mature B-cell production...
  54. ncbi request reprint Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    F Hayakawa
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Oncogene 19:624-31. 2000
    ..Finally, we found constitutive activation of MAP kinase and STAT5 in all clinical samples of AML patients with mutant Flt3. Our study shows the significance of internal tandem duplication of Flt3 receptors for leukemia cell expansion...
  55. ncbi request reprint Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia
    Masahiro Kajiguchi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
    Circ J 71:196-201. 2007
    ..However, because one-third of treated patients fail to respond, the present study was an exploration of the characteristics of responders and non-responders to this treatment regimen...
  56. ncbi request reprint Stable engraftment after a conditioning regimen with fludarabine and melphalan for bone marrow transplantation from an unrelated donor
    Yoshihiro Inamoto
    Department of Hematology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan
    Int J Hematol 83:356-62. 2006
    ....
  57. ncbi request reprint Loss of O6-methylguanine-DNA methyltransferase protein expression is a favorable prognostic marker in diffuse large B-cell lymphoma
    Toshihito Ohno
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 83:341-7. 2006
    ..09; P = .0258). Lack of MGMT protein expression is associated with aberrant promoter DNA methylation and appears to be a useful marker for predicting the survival of DLBCL patients...
  58. pmc Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells
    Ayako Mitsuma
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochim Biophys Acta 1727:125-33. 2005
    ..These findings provide an insight on the mechanism of inducible mRNA expression of the KLF13 gene in erythroid cells...
  59. doi request reprint GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines
    A Furuhata
    Department of Medical Technology, Nagoya University Graduate School of Health Sciences, Nagoya, Japan
    Leukemia 23:1270-7. 2009
    ..Taken together, these results suggest that GATA-1 and/or GATA-2 binding to a GATA site of the 3' enhancer of WT1 played an important role in WT1 gene expression...
  60. ncbi request reprint Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines
    Tomohiro Kajiguchi
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Cancer Sci 97:540-5. 2006
    ..Cotreatment with ATO and the agent, which can induce sustained activation of JNK, might improve the outcome in MM therapy...
  61. ncbi request reprint Wilms' tumor 1 message and protein expression in bone marrow failure syndrome and acute leukemia
    Takashi Iwasaki
    Department of Laboratory Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Pathol Int 57:645-51. 2007
    ....
  62. doi request reprint Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia
    Yuichi Ishikawa
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 83:90-8. 2009
    ..These results collectively suggest that TP53 mutation might be a functionally distinguishable class of mutation...
  63. ncbi request reprint A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RARalpha transcript after consolidation therapy: the Japan Adult Leukemia Study Group (JALSG) APL97 stud
    Norio Asou
    Department of Hematology, Kumamoto University School of Medicine, Kumamoto, Japan
    Blood 110:59-66. 2007
    ....
  64. doi request reprint Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype
    Kyoko Sugimoto
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Int J Hematol 87:451-8. 2008
    ..These results suggest that greater immunosuppression by methotrexate due to low MTHFR enzyme activity decreases the risk of acute GVHD in recipients of allogeneic HSCT...
  65. ncbi request reprint Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene
    Manabu Ninomiya
    Department of Hematology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Genet Cytogenet 169:1-11. 2006
    ..These results suggest that TRL-01 is a useful cell line for studying not only the leukemia-related biology of MLL-ENL but also the intercellular association between leukemia and stroma...
  66. doi request reprint Combinations of cytogenetics and international scoring system can predict poor prognosis in multiple myeloma after high-dose chemotherapy and autologous stem cell transplantation
    Yoshihiro Inamoto
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Am J Hematol 84:283-6. 2009
    ..100%, P = 0.0001). Combinations of cytogenetics and ISS could readily predict prognosis. Quality of response is a poor surrogate marker for ultimate outcome. High-risk patients may need more effective treatment...
  67. ncbi request reprint Immunoglobulin variable region structure and B-cell malignancies
    H Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Int J Hematol 73:47-53. 2001
    ..As the complete nucleotide sequences of the human Ig heavy and Ig light V region loci have now been determined, the study of Ig genetics has entered into the super-information era...
  68. ncbi request reprint Cytomegalovirus antigenemia and outcome of patients treated with pre-emptive ganciclovir: retrospective analysis of 241 consecutive patients undergoing allogeneic hematopoietic stem cell transplantation
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 32:801-7. 2003
    ..Optimal pre-emptive strategy needs to be determined...
  69. ncbi request reprint FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells
    T Kajiguchi
    Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Leukemia 21:2476-84. 2007
    ..These data demonstrate that FLT3 activation induces beta-catenin tyrosine phosphorylation and nuclear localization, and thus suggest a mechanism for the association of FLT3 activation and beta-catenin oncogeneic signaling in AML...
  70. pmc Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome
    Jinglan Xu
    Department of Haematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 140:394-401. 2008
    ..These findings suggest that in situ detection of nuclear NPBC by immunohistochemistry could provide new insights into the pathogenesis and prognosis of AML and MDS...
  71. doi request reprint Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study
    Yuichi Ishikawa
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:2186-92. 2010
    ..A prospective intervention study is required to establish PK-based management in CML patients treated with imatinib...
  72. doi request reprint Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment
    Yosuke Minami
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Hematol 92:664-6. 2010
    ..These results suggest that the monitoring of gene mutations in HSC and progenitors at diagnosis might be helpful for the early detection of TKI-resistant CML patients and facilitate appropriate therapeutic decision...
  73. ncbi request reprint Sustained remission after rituximab-containing chemotherapy for intravascular large B-cell lymphoma
    Kazuyuki Shimada
    Department of Hematology, Ogaki Municipal Hospital, Gifu, Japan
    J Clin Exp Hematop 48:25-8. 2008
    ..She has remained in complete remission for over 3 years after diagnosis. This report suggests that rituximab-containing regimens could be safe and effective for elderly patients with IVL...
  74. doi request reprint Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance
    Junji Hiraga
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Japan
    Blood 113:4885-93. 2009
    ..These findings suggest that some epigenetic mechanisms may be partly related to the down-regulation of CD20 expression after rituximab treatment...
  75. ncbi request reprint Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosmin protein level rarely occurs in myelodysplastic syndromes
    Yuichi Ishikawa
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, and Department of Infectious Diseases, Nagoya University Hospital, Showa Ku, Nagoya, Japan
    Leuk Lymphoma 49:2359-64. 2008
    ..It was concluded that abnormal cytoplasmic localisation and/or significant reduction of NPM1 protein level rarely occurs in MDS. The increase in the number of nuclear NPM1-positive cells may be related to the progression of MDS...
  76. pmc Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy
    Akihiro Abe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 88:471-5. 2008
    ..Our results implicate that the sorted and purified stem cells are useful for more sensitive quantification of BCR-ABL-positive minimal residual disease...
  77. ncbi request reprint [Circumventing resistance to imatinib therapy in chronic myeloid leukemia]
    Yosuke Minami
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gan To Kagaku Ryoho 36:544-7. 2009
    ..A multitude of novel agents have been developed and shown efficacy in overcoming imatinib resistance...
  78. pmc Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis
    Fumihiko Hayakawa
    Department of Hematology and Oncology, Nagoya University, Graduate School of Medicine, Nagoya 466 8550, Japan
    J Biol Chem 283:24420-5. 2008
    ..Our work provides new insights into PML regulation by post-translational modification and new information about the therapeutic mechanism of HDAC inhibitors...
  79. doi request reprint Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan
    Hiroto Narimatsu
    Department of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan
    Int J Hematol 88:154-8. 2008
    ..Although these findings need to be confirmed with a larger number of patients, our data indicate that the MRD level at a given time during the early course in CR does not predict the outcome in Japanese patients...
  80. doi request reprint Presentation and management of intravascular large B-cell lymphoma
    Kazuyuki Shimada
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lancet Oncol 10:895-902. 2009
    ..This Review describes the cutting edge of research on IVLBCL, and discusses the unsolved issues from biological and clinical perspectives to provide a better understanding of this rare lymphoma...
  81. doi request reprint Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan
    Kazuyuki Shimada
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550 Japan
    J Clin Oncol 26:3189-95. 2008
    ..To evaluate the safety and efficacy of rituximab-containing chemotherapies for intravascular large B-cell lymphoma (IVLBCL)...
  82. doi request reprint Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review
    Makoto Murata
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Int J Hematol 88:111-5. 2008
    ..Peripheral blood stem cells might have an advantage in that they are associated with a low incidence of DCL development because PBSCT recipients receive a higher total cell dose than recipients of bone marrow or cord blood cells...
  83. doi request reprint The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0
    Ritsuro Suzuki
    Department of HSCT Data Management, Nagoya University School of Medicine, 1 1 20 Daiko Minami, Higashi ku, Nagoya 461 0047, Japan
    Int J Hematol 91:303-9. 2010
    ..The poor prognosis of CD7(+) CD56(+) M1-M7 suggests that this phenotype may act as a prognostic factor for AML, but this should be confirmed in further studies...
  84. ncbi request reprint Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy
    Akihiro Tomita
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 86:49-57. 2007
    ..Thus, RRBL1 may be useful not only for analyses of mechanisms for the absence of CD20 expression in vitro but also for exploration of therapies against CD20- B-cell malignancies in vivo...
  85. ncbi request reprint A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Clin Cancer Res 13:4575-82. 2007
    ..The aim of this study was to evaluate the antileukemia activity of a novel FLT3 kinase inhibitor, FI-700...
  86. ncbi request reprint Classic polyarteritis nodosa presenting rare clinical manifestations in a patient with hemophilia A
    Tadashi Matsushita
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 83:420-5. 2006
    ..Concomitant hemorrhagic and thrombotic manifestations of cPAN are hardly treatable in patients with coagulation disorders, and the current case may represent a rare transfusion-related complication in hemophilia patients...
  87. ncbi request reprint Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 83:301-8. 2006
    ....
  88. ncbi request reprint Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high-risk acute lymphoblastic leukemia: a metaanalysis
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer 106:2657-63. 2006
    ..Therefore, optimal postremission therapy is a matter of vital concern. In particular, the clinical efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) should be clarified...
  89. ncbi request reprint Efficacy of allogeneic hematopoietic stem cell transplantation depends on cytogenetic risk for acute myeloid leukemia in first disease remission: a metaanalysis
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer 103:1652-8. 2005
    ..Because the karyotype identified at diagnosis is the most relevant prognostic factor for AML, it should be possible to assess the efficacy more accurately on the basis of cytogenetic risk...
  90. ncbi request reprint FLT3 mutations in acute myeloid leukemia
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Methods Mol Med 125:189-97. 2006
    ..Because the detection of FLT3 mutations is fast, easy, and inexpensive, mutation analysis should be performed as a routine test. This chapter describes methods for detecting ITD and D835 mutations in the FLT3 gene...
  91. ncbi request reprint High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Clin Oncol 24:460-6. 2006
    ..A novel therapeutic approach is urgently needed for BCR-ABL-positive acute lymphoblastic leukemia (ALL). In this study, we assessed the efficacy and feasibility of chemotherapy combined with imatinib...
  92. ncbi request reprint Molecular evaluation of endothelial progenitor cells in patients with ischemic limbs: therapeutic effect by stem cell transplantation
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Arterioscler Thromb Vasc Biol 24:e192-6. 2004
    ..It is also important to evaluate endothelial progenitor cell (EPC) contents in different stem cell sources to choose the best material for therapeutic angiogenesis...
  93. ncbi request reprint Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
    Tatsuya Suzuki
    Department of Infectious Diseases, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Blood 106:2854-61. 2005
    ..These results suggest that the NPM1 mutation is not necessarily an early event during leukemogenesis or that leukemia clones with NPM1 mutations are sensitive to chemotherapy...
  94. ncbi request reprint Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: a single-center experience
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 74:418-23. 2005
    ..Our findings suggest that the WHO classification may be strengthened by greater emphasis on genetic/cytogenetic information...
  95. ncbi request reprint Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia
    Yosuke Minami
    Department of Hematology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Blood 102:2969-75. 2003
    ..These findings suggest that the antiapoptotic pathways from FLT3/ITD are more divergent than those from WtFLT3 and may represent targets for drug discovery with the potential of inducing selective cell death of human leukemia cells...
  96. ncbi request reprint Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice
    Tadashi Matsushita
    Department of Hematology, Nagoya University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 325:1163-71. 2004
    ..Such observation may parallel the diverse expression of Alport's manifestations of human individuals with MYH9 disorders and suggest the limited requirement of the gene for maintenance and function of specific organs...
  97. ncbi request reprint Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Eur J Haematol 77:282-7. 2006
    ..Although there are two major scoring systems for the clinical diagnosis of disseminated intravascular coagulation (DIC), the validity of these systems for leukemia-associated DIC remains to be confirmed...
  98. doi request reprint Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography
    Kazuyuki Shimada
    Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan
    Int J Hematol 88:149-53. 2008
    ..These results suggest false-negative results for some types of organ involvement. Careful interpretation of the results of FDG-PET in IVLBCL is thus required...
  99. ncbi request reprint Severe hemorrhagic complications during remission induction therapy for acute promyelocytic leukemia: incidence, risk factors, and influence on outcome
    Masamitsu Yanada
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 78:213-9. 2007
    ..Even after the introduction of all-trans retinoic acid (ATRA), early hemorrhagic death remains a major cause of remission induction failure for acute promyelocytic leukemia (APL)...
  100. ncbi request reprint GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese
    Asahi Hishida
    Department of Hematology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Asian Pac J Cancer Prev 6:251-5. 2005
    ..Incidence case-control studies with a larger statistical power are now required to confirm our findings...
  101. ncbi request reprint SFK-STAT pathway: an alternative and important way to malignancies
    Fumihiko Hayakawa
    Department of Hematology and Oncology, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Ann N Y Acad Sci 1086:213-22. 2006
    ..We also observed STAT5 phosphorylation by Lyn, a member of SFK, in our two recent studies. We introduce these studies and review the literature of STAT activation by SFK and aberrant activation of STAT by oncogenic signals...