Tsutomu Nakashima

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi A perspective from magnetic resonance imaging findings of the inner ear: Relationships among cerebrospinal, ocular and inner ear fluids
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Auris Nasus Larynx 39:345-55. 2012
  2. ncbi Cochlear blood flow and speech perception ability in cochlear implant users
    Tsutomu Nakashima
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 33:165-8. 2012
  3. ncbi Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis
    Naoki Hirasawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Aichi, Japan
    Head Neck Oncol 2:20. 2010
  4. ncbi Visualization of endolymphatic hydrops in patients with Meniere's disease
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 117:415-20. 2007
  5. ncbi Influence of dietary iodine deficiency on the thyroid gland in Slc26a4-null mutant mice
    Tomoyuki Iwata
    Department of Otorhinolaryngology Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Thyroid Res 4:10. 2011
  6. ncbi Effects of anterior inferior cerebellar artery occlusion on cochlear blood flow--a comparison between laser-Doppler and microsphere methods
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Hear Res 162:85-90. 2001
  7. ncbi Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University, Nagoya, Japan
    Acta Otolaryngol 130:338-43. 2010
  8. ncbi Blood flow to the promontory in cochlear otosclerosis
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Showa Ku, Japan
    Clin Otolaryngol 31:110-5. 2006
  9. ncbi Imaging of a congenital perilymphatic fistula
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65, Tsurumai cho, Showa Ku, Japan
    Int J Pediatr Otorhinolaryngol 67:421-5. 2003
  10. ncbi Disorders of cochlear blood flow
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Brain Res Brain Res Rev 43:17-28. 2003

Detail Information

Publications140 found, 100 shown here

  1. ncbi A perspective from magnetic resonance imaging findings of the inner ear: Relationships among cerebrospinal, ocular and inner ear fluids
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Auris Nasus Larynx 39:345-55. 2012
    ..Studies on hydrocephalus, glaucoma and Ménière's disease as a group may deepen our understanding of each disease...
  2. ncbi Cochlear blood flow and speech perception ability in cochlear implant users
    Tsutomu Nakashima
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 33:165-8. 2012
    ..The effect of cochlear blood flow (CBF) on speech perception ability in cochlear implant (CI) users has not been reported. We investigated various factors influencing speech perception including CBF in CI users...
  3. ncbi Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis
    Naoki Hirasawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Aichi, Japan
    Head Neck Oncol 2:20. 2010
    ..To assess the results for local control (LC) and survival in patients with early-stage glottic cancer (GC) who were treated by radiotherapy (RT) with or without chemotherapy...
  4. ncbi Visualization of endolymphatic hydrops in patients with Meniere's disease
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 117:415-20. 2007
    ..Intratympanic administration of steroids has also been used to treat sudden sensorineural hearing loss. We attempted to visualize how the intratympanically administered drug enters the inner ear...
  5. ncbi Influence of dietary iodine deficiency on the thyroid gland in Slc26a4-null mutant mice
    Tomoyuki Iwata
    Department of Otorhinolaryngology Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Thyroid Res 4:10. 2011
    ..abstract:..
  6. ncbi Effects of anterior inferior cerebellar artery occlusion on cochlear blood flow--a comparison between laser-Doppler and microsphere methods
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Hear Res 162:85-90. 2001
    ..From these findings, we infer that during complete interruption of cochlear blood flow in rats, residual laser-Doppler output was essentially attributable to blood flow in the bone surrounding the cochlea...
  7. ncbi Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University, Nagoya, Japan
    Acta Otolaryngol 130:338-43. 2010
    ..Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with Ménière's disease...
  8. ncbi Blood flow to the promontory in cochlear otosclerosis
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Showa Ku, Japan
    Clin Otolaryngol 31:110-5. 2006
    ..To investigate Schwartze sign with measurements of blood flow to the promontory in patients with cochlear otosclerosis...
  9. ncbi Imaging of a congenital perilymphatic fistula
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65, Tsurumai cho, Showa Ku, Japan
    Int J Pediatr Otorhinolaryngol 67:421-5. 2003
    ..Surgery to close the fistula showed a perforation in the stapes footplate...
  10. ncbi Disorders of cochlear blood flow
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Brain Res Brain Res Rev 43:17-28. 2003
    ..There have been many reports of hearing loss that were considered to be caused by blood flow disturbance in the cochlea. However, direct evidence of blood flow disturbance in the cochlea is still lacking in most of the cases...
  11. ncbi 3 Tesla magnetic resonance imaging obtained 4 hours after intravenous gadolinium injection in patients with sudden deafness
    Mitsuhiko Tagaya
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 130:665-9. 2010
    ..The signal intensity ratio (SIR) between the cochlea and cerebellum may be a good indicator of disruption of the blood-labyrinthine barrier...
  12. ncbi Endolymphatic space imaging in patients with delayed endolymphatic hydrops
    Sachio Kasai
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Acta Otolaryngol 129:1169-74. 2009
    ..Magnetic resonance imaging (MRI) after intratympanic gadolinium injection can reveal endolymphatic hydrops (ELH) in patients with delayed ELH (DELH). Patients with contralateral DELH may have bilateral ELH...
  13. ncbi Relationship between the degree of endolymphatic hydrops and electrocochleography
    Masako Yamamoto
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Audiol Neurootol 15:254-60. 2010
    ..This may imply that elevation of the SP/AP ratio is related to not only the degree of endolymphatic hydrops but also to the persistence of hydrops...
  14. ncbi Relationship between adenoid size and severity of obstructive sleep apnea in preschool children
    Mitsuhiko Tagaya
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Int J Pediatr Otorhinolaryngol 76:1827-30. 2012
    ..To investigate the contributions of adenoid and tonsil sizes to obstructive sleep apnea syndrome (OSAS) in normal-weight children in two age categories: preschool and schoolchildren...
  15. ncbi Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor α in patients with Ménière's disease and sudden sensorineural hearing loss
    Naoki Nishio
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Life Sci 92:541-6. 2013
    ....
  16. ncbi Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya, 466 8550, Japan
    Eur Radiol 18:920-4. 2008
    ..In conclusion, by optimizing the inversion time, endolymphatic space, perilymphatic space and surrounding bone can be separately visualized on a single image using a 3D-IR TSE with real reconstruction...
  17. ncbi Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Auris Nasus Larynx 37:220-2. 2010
    ..The correlation between the degree of endolymphatic hydrops observed by MRI and hearing level in patients with Meniere's disease offers a promising new method to study the progression of Meniere's disease...
  18. ncbi Lateral semicircular canal and vertigo in patients with large vestibular aqueduct syndrome
    Ieda Maria Ishida
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 27:788-92. 2006
    ....
  19. ncbi Long-term follow-up in patients with Pendred syndrome: vestibular, auditory and other phenotypes
    Makoto Sugiura
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 466 8550 Nagoya, Japan
    Eur Arch Otorhinolaryngol 262:737-43. 2005
    ..Whether environmental factors or a subtype of the Pds mutation H723R are related to the long-term outcome for these patients must be clarified...
  20. ncbi The effects of aging on distortion-product otoacoustic emissions in adults with normal hearing
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Morioka, Aichi, Japan
    Ear Hear 29:176-84. 2008
    ..Therefore, in selecting subjects, we applied the stringent criterion in pure-tone thresholds (PTT) to limit dispersion among normal-hearing thresholds...
  21. ncbi Pathogenetic role of increased nasal resistance in obese patients with obstructive sleep apnea syndrome
    Mitsuhiko Tagaya
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan
    Am J Rhinol Allergy 24:51-4. 2010
    ..The role of increased nasal resistance in obstructive sleep apnea syndrome (OSAS) remains controversial. The aim of this study was to examine the pathogenetic role of nasal obstruction in obese patients with OSAS...
  22. ncbi MR imaging of the cochlear modiolus after intratympanic administration of Gd-DTPA
    Hisashi Kawai
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 9:23-9. 2010
    ..Although the cochlear modiolus has been considered the route for this communication, this has not been confirmed through direct visualization of its enhancement...
  23. ncbi Estimation of gadolinium-induced T1-shortening with measurement of simple signal intensity ratio between the cochlea and brain parenchyma on 3D-FLAIR: correlation with T1 measurement by TI scout sequence
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 9:17-22. 2010
    ..We evaluated the feasibility of measuring simple signal intensity ratio by correlating rapid T(1) measurements using an inversion time (TI) scout sequence...
  24. ncbi Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Ménière's disease in a Japanese population
    Masaaki Teranishi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    DNA Cell Biol 31:1555-62. 2012
    ..In conclusion, no significant associations between the polymorphisms of GPX1, PON1, PON2, and SOD2 and risk of SSNHL and Ménière's disease were observed in this Japanese case-control study...
  25. ncbi Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection
    Rui Sano
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Japan
    Acta Otolaryngol 132:241-6. 2012
    ..Using heavily T2-weighted 3D-FLAIR MRI, visualization of endolymphatic hydrops (EH) was possible in the vestibule and the cochlea after a standard intravenous dose of Gd...
  26. ncbi Contrast enhancement of the inner ear after intravenous administration of a standard or double dose of gadolinium contrast agents
    Hirokazu Suzuki
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Japan
    Acta Otolaryngol 131:1025-31. 2011
    ..Imaging of the endolymphatic space was possible in most cases after administering a standard dose of gadolinium (Gd) by using heavily T2-weighted 3D fluid-attenuated inversion recovery (hT(2)W-3D-FLAIR) magnetic resonance imaging (MRI)...
  27. ncbi Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo
    Masaaki Teranishi
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Eur Arch Otorhinolaryngol 266:1871-7. 2009
    ..In conclusion, 3T MRI after intratympanic injection of Gd-DTPA revealed endolymphatic hydrops both in the cochlea and in the vestibule in the patients with fluctuating hearing loss without vertigo...
  28. ncbi Individual differences in the permeability of the round window: evaluating the movement of intratympanic gadolinium into the inner ear
    Mayumi Yoshioka
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Otol Neurotol 30:645-8. 2009
    ..We used magnetic resonance imaging (MRI) to evaluate whether and how intratympanically administered gadolinium (Gd) enters the inner ear...
  29. ncbi Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya, Japan
    Radiat Med 26:597-602. 2008
    ..The purpose of this study was to evaluate how frequently this occurs and to investigate the specific features of patients who lack this communication...
  30. ncbi Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Magn Reson Imaging 31:210-4. 2010
    ....
  31. ncbi Blood flow in the ears of patients receiving cochlear implants
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Ann Otol Rhinol Laryngol 113:426-30. 2004
    ..In the patients with idiopathic progressive sensorineural hearing loss, the CBF was significantly lower in patients more than 40 years old. Intracochlear calcification following meningitis appears to be associated with a reduced CBF...
  32. ncbi Distribution of pendrin in the organ of Corti of mice observed by electron immunomicroscopy
    Takahiko Yoshino
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 4668550, Japan
    Eur Arch Otorhinolaryngol 263:699-704. 2006
    ..Our study revealed that pendrin occurs in the organ of Corti. The role of pendrin in the organ of Corti and its association with the Cl- or pH regulation of neurotransmission require further study...
  33. ncbi Endolymphatic hydrops and blood-labyrinth barrier in Ménière's disease
    Mitsuhiko Tagaya
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi, Japan
    Acta Otolaryngol 131:474-9. 2011
    ..The blood-labyrinth barrier is impaired in association with the hydrops grade in Ménière's disease...
  34. ncbi Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with sudden sensorineural hearing loss
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Japan
    Laryngoscope 120:791-5. 2010
    ..To investigate the recently reported association of the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with sudden sensorineural hearing loss (SSNHL), we analyzed data from a community-based Japanese population...
  35. ncbi Detection of presumed hemorrhage in the ampullar endolymph of the semicircular canal: a case report
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 8:187-91. 2009
    ..The 3D-FLAIR images demonstrated a small amount of focal hemorrhage in the labyrinthine fluid that may have been overlooked on T(1)-weighted images...
  36. ncbi Peak width in multifrequency tympanometry and endolymphatic hydrops revealed by magnetic resonance imaging
    Ken Kato
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 33:912-5. 2012
    ....
  37. ncbi Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings and prognosis in sudden sensorineural hearing loss
    Tadao Yoshida
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 118:1433-7. 2008
    ..However, the relationship between 3D-FLAIR findings and hearing prognosis is unclear. Our objective was to evaluate the relationship between the results of 3D-FLAIR MRI at 3 Tesla and prognosis in sudden SNHL...
  38. ncbi Comparison of computed tomography and magnetic resonance imaging for evaluation of cholesteatoma with labyrinthine fistulae
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 122:1121-5. 2012
    ..To compare preoperative computed tomography (CT) and magnetic resonance imaging (MRI) findings to the clinical features in patients with middle ear cholesteatoma with labyrinthine fistulae...
  39. ncbi Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes
    Naoki Nishio
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gene 499:226-30. 2012
    ..214 (CI: 0.581-2.538) in nondiabetic subjects. We conclude that CFH Y402H polymorphism and SSNHL risk are significantly related, and that diabetic CFH Y402H minor allele carriers may be susceptible to SSNHL...
  40. ncbi Distortion product otoacoustic emissions and tympanometric measurements in an adult population-based study
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi, Japan
    Auris Nasus Larynx 33:397-401. 2006
    ....
  41. ncbi Hearing loss in patients with enlarged vestibular aqueduct: air-bone gap and audiological Bing test
    Tamie Mimura
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Int J Audiol 44:466-9. 2005
    ....
  42. ncbi The Ala54Thr polymorphism in the fatty acid-binding protein 2 (FABP2) gene is associated with hearing impairment: a preliminary report
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu City, Aichi Prefecture 474 8511, Japan
    Auris Nasus Larynx 37:496-9. 2010
    ..The FABP2 gene has been proposed as a candidate gene for diabetes and obesity. This study evaluates the hearing impairment risk in the Ala54Thr polymorphism of FABP2 in middle-aged and elderly Japanese...
  43. ncbi Detection of herpesvirus DNAs in perilymph obtained from patients with sensorineural hearing loss by real-time polymerase chain reaction
    Saiko Sugiura
    Department of Otolaryngology, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Laryngoscope 114:2235-8. 2004
    ....
  44. ncbi The impact of arterial sclerosis on hearing with and without occupational noise exposure: a population-based aging study in males
    Mayumi Yoshioka
    Department of Otorhinolaryngology Cognitive and Speech Medicine, Nagoya University School of Medicine, 65 Tsuruma cho, Showa Ward, Nagoya City, Aichi Prefecture 466 8550, Japan
    Auris Nasus Larynx 37:558-64. 2010
    ....
  45. ncbi Response of cochlear blood flow to prostaglandin E1 applied topically to the round window
    Mitsuo Tominaga
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Acta Otolaryngol 126:232-6. 2006
    ..The CBF response to PGE1 administration was similar before and after occlusion of the stapedial artery...
  46. ncbi Signal alteration of the cochlear perilymph on 3 different sequences after intratympanic Gd-DTPA administration at 3 tesla: comparison of 3D-FLAIR, 3D-T1-weighted imaging, and 3D-CISS
    Masahiro Yamazaki
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Magn Reson Med Sci 9:65-71. 2010
    ....
  47. ncbi Imaging analysis in cases with inflammation-induced sensorineural hearing loss
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 129:239-43. 2009
    ..3D-FLAIR imaging is sensitive to inflammatory inner ear disturbances and may be a useful method in investigating the severity of inner ear disturbance in cases of inflammation-induced SNHL...
  48. ncbi Morphological examination of upper airway in obstructive sleep apnea
    Hidehito Yagi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Auris Nasus Larynx 36:444-9. 2009
    ..An aim of this study was to assess the predictive power of an otorhinolaryngological examination of the upper airway to identify risk factors of obstructive sleep apnea syndrome (OSAS) in the patients...
  49. ncbi Pharyngeal morphology: a determinant of successful nasal surgery for sleep apnea
    Mami Morinaga
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 119:1011-6. 2009
    ..To estimate the effectiveness of nasal surgery on the occurrence of sleep apnea, and to analyze the pharyngeal morphology of apnea patients whose sleep-disordered breathing was ameliorated postoperatively...
  50. ncbi Significance of a screening device (Apnomonitor 5) for sleep apnea syndrome
    Hidehito Yagi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Showa, Aichi, Japan
    Auris Nasus Larynx 36:176-80. 2009
    ..The objective was to evaluate the significance of a portable sleep-monitoring device (Apnomonitor 5, Chest Co., Tokyo, Japan) to diagnose sleep apnea syndrome (SAS)...
  51. ncbi Imaging of Ménière's disease after intravenous administration of single-dose gadodiamide: utility of subtraction images with different inversion time
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 11:213-9. 2012
    ..Subtraction significantly improved the contrast noise ratio between endolymph and perilymph and the subjective visibility score for endolymphatic space. The 24 patients with the suspect of Ménière's disease were included...
  52. ncbi Continuous positive airway pressure intolerance associated with elevated nasal resistance is possible mechanism of complex sleep apnea syndrome
    Chie Nakazaki
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Sleep Breath 16:747-52. 2012
    ..However, the pathophysiology of CompSAS remains controversial...
  53. ncbi Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection
    Masahiro Yamazaki
    Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuroradiology 54:1161-9. 2012
    ....
  54. ncbi Imaging of endolymphatic and perilymphatic fluid after intravenous administration of single-dose gadodiamide
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 11:145-50. 2012
    ..We observed high signal of cochlear endolymph in 17 ears with cochlear endolymphatic hydrops but not 11 ears without cochlear endolymphatic hydrops...
  55. ncbi Blood flow measurements in the ears of patients receiving cochlear implants
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Ann Otol Rhinol Laryngol 111:998-1001. 2002
    ..We conclude that laser-Doppler flowmetry is both relatively safe and useful for measuring blood flow in the ears during cochlear implantation procedures...
  56. ncbi Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu City, Aichi Prefecture 474 8511, Japan
    BMC Med Genet 12:35. 2011
    ..The aim of this study is to investigate the effects of the methionine synthase (MTR) A2756G and methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphisms on the risk of hearing impairment in middle-aged and elderly Japanese...
  57. ncbi Prediction of gastroesophageal reflux in otitis media with effusion in adults
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Acta Otolaryngol 127:470-3. 2007
    ..The measurement of pepsinogen I (PGI) in middle-ear effusions (MEEs) and a questionnaire on the frequency symptoms of gastroesophageal reflux (GER) disease are tools that can be used to screen for the existence of GER...
  58. ncbi 3D-FLAIR MRI findings in a patient with Ramsay Hunt syndrome
    Makoto Sugiura
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Acta Otolaryngol 127:547-9. 2007
    ..3D-FLAIR could be a useful diagnostic tool in the early stages of Ramsay Hunt syndrome...
  59. ncbi Cochlear modiolus and lateral semicircular canal in sudden deafness
    Ieda Maria Ishida
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Acta Otolaryngol 127:1157-61. 2007
    ..Reduced cochlear modiolus area and inner area of the lateral semicircular canal (LSCC) may be associated with insufficient maturation of the inner ear...
  60. ncbi Effects of nasal surgery on sleep quality in obstructive sleep apnea syndrome with nasal obstruction
    Seiichi Nakata
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Am J Rhinol 22:59-63. 2008
    ..A prospective study was performed in OSAS patients who underwent isolated nasal surgery in a tertiary referral center...
  61. ncbi Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Japan
    Laryngoscope 119:938-43. 2009
    ..To investigate the association between the Lys198Asn (G/T) polymorphism (rs5370) in the endothelin-1 gene (EDN1) and hearing impairment in middle-aged and elderly Japanese...
  62. ncbi Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate
    Hirokazu Suzuki
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 131:130-5. 2011
    ..There was no morphological change in the stria vascularis after Gd-DTPA or Gd-DTPA-BMA was placed on the round window of guinea pigs...
  63. ncbi Contribution of 1425G/A polymorphism in protein kinase C-Eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu City, Aichi Prefecture, Japan
    J Neurogenet 25:82-7. 2011
    ....
  64. ncbi Visualization of endolymphatic hydrops in Ménière's disease with single-dose intravenous gadolinium-based contrast media using heavily T(2)-weighted 3D-FLAIR
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa, Nagoya, Japan
    Magn Reson Med Sci 9:237-42. 2010
    ..This technique can be implemented in a clinical setting...
  65. ncbi Cochlear blood flow during occlusion and reperfusion of the anterior inferior cerebellar artery--effect of topical application of dexamethasone to the round window
    Hironao Otake
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Acta Otolaryngol 129:127-31. 2009
    ..Topical application of dexamethasone may support autoregulation of cochlear blood flow (CBF), although it had no direct effect on CBF...
  66. ncbi Tinnitus and brain MRI findings in Japanese elderly
    Saiko Sugiura
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
    Acta Otolaryngol 128:525-9. 2008
    ..There is evidence of an inverse association between cerebral infarction and tinnitus in this study. The effects of cerebral infarction on tinnitus could be explained by a neurophysiological model of tinnitus...
  67. ncbi Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 7:85-91. 2008
    ..We evaluated whether 3D-FLAIR-VFL could replace 3D-FLAIR-CONV in detecting endolymphatic hydrops after intratympanic Gd-DTPA administration...
  68. ncbi Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss
    Terukazu Mizuno
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Eur Arch Otorhinolaryngol 266:351-5. 2009
    ..CMV DNA was not detected in any of the patients with sudden SNHL or enlarged vestibular aqueduct-associated SNHL. The features of CMV-associated SNHL were more asymmetric than those of CMV-negative bilateral SNHL...
  69. ncbi Changes in cochlear blood flow due to endotoxin-induced otitis media
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
    Ann Otol Rhinol Laryngol 113:450-4. 2004
    ..The results showed a functional influence upon CBF by endotoxin-induced otitis media. The significance of prophylactic use of the drug is also discussed in regard to the effect on CBF following otitis media...
  70. ncbi Limitations of FDG-PET and FDG-PET with computed tomography for detecting synchronous cancer in pharyngeal cancer
    Hidenori Suzuki
    Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, Japan
    Arch Otolaryngol Head Neck Surg 134:1191-5. 2008
    ..Good results have been reported from the use of FDG-PET and FDG-PET/CT in staging head and neck SCC (HNSCC). An additional advantage is that both techniques are expected to prove useful in detecting synchronous cancer...
  71. ncbi Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma
    Masahiro Yamazaki
    Department of Radiology, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuroradiology 51:855-63. 2009
    ....
  72. ncbi 3D-FLAIR MRI in facial nerve paralysis with and without audio-vestibular disorder
    Seiichi Nakata
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 130:632-6. 2010
    ..This MRI technique may contribute to elucidation of the pathology of Ramsay Hunt syndrome and Bell's palsy...
  73. ncbi Increased sensitivity to low concentration gadolinium contrast by optimized heavily T2-weighted 3D-FLAIR to visualize endolymphatic space
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Magn Reson Med Sci 9:73-80. 2010
    ....
  74. ncbi Otoacoustic emissions, ear fullness and tinnitus in the recovery course of sudden deafness
    Ieda M Ishida
    Nagoya University Graduate School of Medicine, Department of Otorhinolaryngology, 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Auris Nasus Larynx 35:41-6. 2008
    ..This study aimed to investigate how the symptoms of ear fullness, tinnitus and otoacoustic emissions (OAE) change in relation to the recovery course of pure tone audiometry thresholds (PTA) in sudden deafness (SD)...
  75. ncbi Inner ear hemorrhage in systemic lupus erythematosus
    Makoto Sugiura
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 116:826-8. 2006
    ..This is the first published case of inner ear hemorrhage in a patient with SLE. Our findings suggest that inner ear hemorrhage is associated with hearing deterioration in some patients with SLE...
  76. ncbi Visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: comparison of 2D and 3D real inversion recovery imaging
    Shinji Naganawa
    Department of Radiology, Nagoya University, Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Magn Reson Med Sci 10:101-6. 2011
    ..This technique enables differentiation of bone and endo- and perilymph space on a single image but requires 15 min of scan time. Therefore, we compared it with 2D real IR, which is faster...
  77. ncbi Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients
    Akihiro Terada
    Department of Otorhinolaryngology, Japanese Red Cross Nagoya Daiichi Hospital, 3 35 Michishita cho, Nakamura ku, Nagoya, Aichi 453 8511, Japan
    Eur Arch Otorhinolaryngol 268:429-35. 2011
    ..6%. SN-positive patients exhibited a tendency toward cancer recurrence. There were three cases of false negatives not conforming to the SN concept and their rate was 7.9%. Positive SN had a negative impact on patient survival...
  78. ncbi Histidine-containing phosphotransfer (HPt) signal transducers implicated in His-to-Asp phosphorelay in Arabidopsis
    T Suzuki
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Japan
    Plant Cell Physiol 39:1258-68. 1998
    ..It was thus suggested that the uncovered sensors-AHPs-ARRs lineups may play important roles in propagating environmental stimuli through the multistep His-Asp phosphorelay in Arabidopsis...
  79. ncbi Two types of putative nuclear factors that physically interact with histidine-containing phosphotransfer (Hpt) domains, signaling mediators in His-to-Asp phosphorelay, in Arabidopsis thaliana
    T Suzuki
    School of Agriculture, BioScience Center, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 42:37-45. 2001
    ....
  80. ncbi Systematic mutational analysis revealing the functional domain organization of Escherichia coli nucleoid protein H-NS
    C Ueguchi
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Japan
    J Mol Biol 263:149-62. 1996
    ..This finding is also addressed with regard to a unique regulatory mechanism (i.e. silencing) for the bgl operon, which is partly mediated by H-NS...
  81. ncbi Response regulators implicated in His-to-Asp phosphotransfer signaling in Arabidopsis
    A Imamura
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya 464, Japan
    Proc Natl Acad Sci U S A 95:2691-6. 1998
    ..In vivo and in vitro evidence that ARRs can function as phosphoaccepting response regulators was obtained by employing the Escherichia coli His-Asp phosphotransfer signaling system...
  82. ncbi Prevalence of self-perceived auditory problems and their relation to audiometric thresholds in a middle-aged to elderly population
    Yasue Uchida
    Department of Otorhinolaryngology, Chubu National Hospital, Obu, Aichi, Japan
    Acta Otolaryngol 123:618-26. 2003
    ....
  83. ncbi Tympanometric findings in patients with enlarged vestibular aqueducts
    Eisuke Sato
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Japan
    Laryngoscope 112:1642-6. 2002
    ....
  84. ncbi Molecular cloning of chicken vasoactive intestinal polypeptide receptor complementary DNA, tissue distribution and chromosomal localization
    N Kansaku
    Laboratory of Animal Physiology, School of Agricultural Sciences, Nagoya University, Chikusa, Nagoya, Japan 464 860
    Biol Reprod 64:1575-81. 2001
    ..Chicken VIPR shows high homology with mammalian type I VIPR but, in some part, possesses similarity of amino acid sequence. Expression of VIPR in various tissues supports diverse functions for VIP in the chicken...
  85. ncbi Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway
    T Suzuki
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
    Placenta 23:475-82. 2002
    ..Our findings also suggest that NEP/CD10 may play a functional role in the process of trophoblast differentiation...
  86. ncbi Differing effects on the inner ear of three gentamicin compounds: GM-C1, -C2 and -C1a
    Masamichi Kobayashi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 123:916-22. 2003
    ..In this study we investigated differences in cochleo- and vestibulotoxicity between the three compounds..
  87. ncbi Effects of trolox, locally applied on round windows, on cisplatin-induced ototoxicity in guinea pigs
    Masa aki Teranishi
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Pediatr Otorhinolaryngol 67:133-9. 2003
    ..In the present study, we attempted to suppress CDDP-induced ototoxicity in guinea pigs by administering trolox, a water-soluble analogue of alpha-tocopherol which is a natural lipid-soluble antioxidant, locally on round windows...
  88. ncbi Serial MR imaging studies in enlarged endolymphatic duct and sac syndrome
    Shinji Naganawa
    Department of Radiology, Nagoya University School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya 466 8550, Japan
    Eur Radiol 12:S114-7. 2002
    ..The finding that the EES volume and signal intensity vary dynamically independently of hearing is important for future research into the pathophysiology of hearing loss in this syndrome...
  89. ncbi Changes in laryngeal sensation evaluated with a new method before and after radiotherapy
    Kikuko Ozawa
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Shouwa ku, Nagoya, Aichi 466 8550, Japan
    Eur Arch Otorhinolaryngol 267:811-6. 2010
    ..Laryngeal sensation recovered in most cases within 1 year after radiotherapy. The present study clearly demonstrates the deterioration of laryngeal sensation with radiotherapy...
  90. ncbi Simultaneous three-dimensional visualization of the intra-parotid facial nerve and parotid duct using a three-dimensional reversed FISP sequence with diffusion weighting
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 9:153-8. 2010
    ..We also present volumetric representation of the facial nerve and duct...
  91. ncbi Imaging findings in a case with cholesteatoma in complete aural atresia
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Otolaryngol 31:297-9. 2010
    ....
  92. ncbi Contrast-enhanced MR imaging of the endolymphatic sac in patients with sudden hearing loss
    Shinji Naganawa
    Department of Radiology, Nagoya University School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya 466 8550, Japan
    Eur Radiol 12:1121-6. 2002
    ....
  93. ncbi Endolymphatic hydrops of the labyrinth visualized on noncontrast MR imaging: a case report
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Magn Reson Med Sci 8:43-6. 2009
    ..This is the first imaging report to show endolymphatic hydrops visualized by noncontrast-enhanced MR imaging in a living human patient...
  94. ncbi Contribution of stapedial artery to blood flow in the cochlea and its surrounding bone
    Hiroshi Yamamoto
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hear Res 186:69-74. 2003
    ..Simultaneous occlusion of the SA and AICA decreased the LD output to 27.0+/-5.5% of the baseline value. The role of the contribution of the SA and AICA to the LD output is discussed...
  95. ncbi Round window membrane in young and aged C57BL/6 mice
    Yoko Kitamura
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, 466 8550, Nagoya, Japan
    Hear Res 174:142-8. 2002
    ..Confocal laser microscopy using fluorescein isothiocyanate(FITC)-wheat germ agglutinin (WGA) staining was used to identify WGA-positive fibers in the middle layer of the RWM, which changed in a similar manner to the fibers in aging skin...
  96. ncbi Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings in patients with sudden sensorineural hearing loss
    Makoto Sugiura
    Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Laryngoscope 116:1451-4. 2006
    ..To evaluate the inner ear in sudden sensorineural hearing loss (SNHL) using three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) at 3 Tesla (T)...
  97. ncbi Thirty-year trends in sudden deafness from four nationwide epidemiological surveys in Japan
    Masaaki Teranishi
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 127:1259-65. 2007
    ..Hypertension and diabetes mellitus could contribute to the etiology of this disorder...
  98. ncbi Intraoperative diagnosis of cancer metastasis in sentinel lymph node of oral cancer patients
    Akihiro Terada
    Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Oral Oncol 44:838-43. 2008
    ..6%, respectively. All indexes of intraoperative frozen section analysis were superior to imprint cytology. In our experience, multislice frozen section analysis surpasses imprint cytology in intraoperative diagnosis of SLN biopsy...
  99. ncbi Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings in a patient with cochlear otosclerosis
    Makoto Sugiura
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Auris Nasus Larynx 35:269-72. 2008
    ..Our findings suggest that the breakdown of the blood-labyrinth barrier is associated with a part of SNHL in cochlear otosclerosis...
  100. ncbi Nasal resistance for determinant factor of nasal surgery in CPAP failure patients with obstructive sleep apnea syndrome
    Seiichi Nakata
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Rhinology 43:296-9. 2005
    ....
  101. ncbi Small cell carcinoma of the larynx treated with irinotecan and cisplatin
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Auris Nasus Larynx 33:223-5. 2006
    ..For the cure of the aggressive lethal behavior of this disease, chemotherapy with CPT-11 might be effective to improve median survival of patients with small cell carcinomas of the larynx...