Tsutomu Nakashima

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. doi request reprint A perspective from magnetic resonance imaging findings of the inner ear: Relationships among cerebrospinal, ocular and inner ear fluids
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Auris Nasus Larynx 39:345-55. 2012
  2. doi request reprint Cochlear blood flow and speech perception ability in cochlear implant users
    Tsutomu Nakashima
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 33:165-8. 2012
  3. pmc Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis
    Naoki Hirasawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Aichi, Japan
    Head Neck Oncol 2:20. 2010
  4. ncbi request reprint Imaging of a congenital perilymphatic fistula
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65, Tsurumai cho, Showa Ku, Japan
    Int J Pediatr Otorhinolaryngol 67:421-5. 2003
  5. ncbi request reprint Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University, Nagoya, Japan
    Acta Otolaryngol 130:338-43. 2010
  6. pmc Influence of dietary iodine deficiency on the thyroid gland in Slc26a4-null mutant mice
    Tomoyuki Iwata
    Department of Otorhinolaryngology Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Thyroid Res 4:10. 2011
  7. ncbi request reprint Visualization of endolymphatic hydrops in patients with Meniere's disease
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 117:415-20. 2007
  8. ncbi request reprint Disorders of cochlear blood flow
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Brain Res Brain Res Rev 43:17-28. 2003
  9. ncbi request reprint Effects of anterior inferior cerebellar artery occlusion on cochlear blood flow--a comparison between laser-Doppler and microsphere methods
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Hear Res 162:85-90. 2001
  10. ncbi request reprint Blood flow to the promontory in cochlear otosclerosis
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Showa Ku, Japan
    Clin Otolaryngol 31:110-5. 2006

Detail Information

Publications149 found, 100 shown here

  1. doi request reprint A perspective from magnetic resonance imaging findings of the inner ear: Relationships among cerebrospinal, ocular and inner ear fluids
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Auris Nasus Larynx 39:345-55. 2012
    ..Studies on hydrocephalus, glaucoma and Ménière's disease as a group may deepen our understanding of each disease...
  2. doi request reprint Cochlear blood flow and speech perception ability in cochlear implant users
    Tsutomu Nakashima
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 33:165-8. 2012
    ..The effect of cochlear blood flow (CBF) on speech perception ability in cochlear implant (CI) users has not been reported. We investigated various factors influencing speech perception including CBF in CI users...
  3. pmc Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis
    Naoki Hirasawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Aichi, Japan
    Head Neck Oncol 2:20. 2010
    ..To assess the results for local control (LC) and survival in patients with early-stage glottic cancer (GC) who were treated by radiotherapy (RT) with or without chemotherapy...
  4. ncbi request reprint Imaging of a congenital perilymphatic fistula
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65, Tsurumai cho, Showa Ku, Japan
    Int J Pediatr Otorhinolaryngol 67:421-5. 2003
    ..Surgery to close the fistula showed a perforation in the stapes footplate...
  5. ncbi request reprint Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University, Nagoya, Japan
    Acta Otolaryngol 130:338-43. 2010
    ..Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with Ménière's disease...
  6. pmc Influence of dietary iodine deficiency on the thyroid gland in Slc26a4-null mutant mice
    Tomoyuki Iwata
    Department of Otorhinolaryngology Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Thyroid Res 4:10. 2011
    ..abstract:..
  7. ncbi request reprint Visualization of endolymphatic hydrops in patients with Meniere's disease
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 117:415-20. 2007
    ..Intratympanic administration of steroids has also been used to treat sudden sensorineural hearing loss. We attempted to visualize how the intratympanically administered drug enters the inner ear...
  8. ncbi request reprint Disorders of cochlear blood flow
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Brain Res Brain Res Rev 43:17-28. 2003
    ..There have been many reports of hearing loss that were considered to be caused by blood flow disturbance in the cochlea. However, direct evidence of blood flow disturbance in the cochlea is still lacking in most of the cases...
  9. ncbi request reprint Effects of anterior inferior cerebellar artery occlusion on cochlear blood flow--a comparison between laser-Doppler and microsphere methods
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Hear Res 162:85-90. 2001
    ..From these findings, we infer that during complete interruption of cochlear blood flow in rats, residual laser-Doppler output was essentially attributable to blood flow in the bone surrounding the cochlea...
  10. ncbi request reprint Blood flow to the promontory in cochlear otosclerosis
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Showa Ku, Japan
    Clin Otolaryngol 31:110-5. 2006
    ..To investigate Schwartze sign with measurements of blood flow to the promontory in patients with cochlear otosclerosis...
  11. doi request reprint 3 Tesla magnetic resonance imaging obtained 4 hours after intravenous gadolinium injection in patients with sudden deafness
    Mitsuhiko Tagaya
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 130:665-9. 2010
    ..The signal intensity ratio (SIR) between the cochlea and cerebellum may be a good indicator of disruption of the blood-labyrinthine barrier...
  12. doi request reprint Endolymphatic space imaging in patients with delayed endolymphatic hydrops
    Sachio Kasai
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Acta Otolaryngol 129:1169-74. 2009
    ..Magnetic resonance imaging (MRI) after intratympanic gadolinium injection can reveal endolymphatic hydrops (ELH) in patients with delayed ELH (DELH). Patients with contralateral DELH may have bilateral ELH...
  13. doi request reprint Relationship between the degree of endolymphatic hydrops and electrocochleography
    Masako Yamamoto
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Audiol Neurootol 15:254-60. 2010
    ..This may imply that elevation of the SP/AP ratio is related to not only the degree of endolymphatic hydrops but also to the persistence of hydrops...
  14. doi request reprint Association between polymorphisms in genes encoding methylenetetrahydrofolate reductase and the risk of Ménière's disease
    Yang Huang
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurogenet 27:5-10. 2013
    ..503 (95% CI, 1.064-2.123) in model 1 and 1.505 (95% CI, 1.045-2.167) in model 2. Our results imply that the MTHFR C677T and A1298C polymorphisms are associated with the risk of MD...
  15. doi request reprint Relationship between adenoid size and severity of obstructive sleep apnea in preschool children
    Mitsuhiko Tagaya
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Int J Pediatr Otorhinolaryngol 76:1827-30. 2012
    ..To investigate the contributions of adenoid and tonsil sizes to obstructive sleep apnea syndrome (OSAS) in normal-weight children in two age categories: preschool and schoolchildren...
  16. doi request reprint Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor α in patients with Ménière's disease and sudden sensorineural hearing loss
    Naoki Nishio
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Life Sci 92:541-6. 2013
    ....
  17. doi request reprint Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya, 466 8550, Japan
    Eur Radiol 18:920-4. 2008
    ..In conclusion, by optimizing the inversion time, endolymphatic space, perilymphatic space and surrounding bone can be separately visualized on a single image using a 3D-IR TSE with real reconstruction...
  18. ncbi request reprint Long-term follow-up in patients with Pendred syndrome: vestibular, auditory and other phenotypes
    Makoto Sugiura
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 466 8550 Nagoya, Japan
    Eur Arch Otorhinolaryngol 262:737-43. 2005
    ..Whether environmental factors or a subtype of the Pds mutation H723R are related to the long-term outcome for these patients must be clarified...
  19. ncbi request reprint Lateral semicircular canal and vertigo in patients with large vestibular aqueduct syndrome
    Ieda Maria Ishida
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 27:788-92. 2006
    ....
  20. doi request reprint Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Auris Nasus Larynx 37:220-2. 2010
    ..The correlation between the degree of endolymphatic hydrops observed by MRI and hearing level in patients with Meniere's disease offers a promising new method to study the progression of Meniere's disease...
  21. doi request reprint Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss
    Mariko Shimono
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 34:1241-6. 2013
    ..However, evaluation of the size of the endolymphatic space has not been reported. We attempted to visualize EH in ALHL using magnetic resonance imaging (MRI)...
  22. ncbi request reprint The effects of aging on distortion-product otoacoustic emissions in adults with normal hearing
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Morioka, Aichi, Japan
    Ear Hear 29:176-84. 2008
    ..Therefore, in selecting subjects, we applied the stringent criterion in pure-tone thresholds (PTT) to limit dispersion among normal-hearing thresholds...
  23. doi request reprint Endolymphatic hydrops and blood-labyrinth barrier in Ménière's disease
    Mitsuhiko Tagaya
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi, Japan
    Acta Otolaryngol 131:474-9. 2011
    ..The blood-labyrinth barrier is impaired in association with the hydrops grade in Ménière's disease...
  24. doi request reprint Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss
    Mariko Hiramatsu
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurogenet 26:387-96. 2012
    ..In conclusion, the IL-6 C - 572G polymorphism is associated with a risk of SSNHL. Because permeability of blood vessels in the inner ear is frequently increased in patients with SSNHL, inflammation of the inner ear might be involved...
  25. ncbi request reprint MR imaging of the cochlear modiolus after intratympanic administration of Gd-DTPA
    Hisashi Kawai
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 9:23-9. 2010
    ..Although the cochlear modiolus has been considered the route for this communication, this has not been confirmed through direct visualization of its enhancement...
  26. ncbi request reprint Estimation of gadolinium-induced T1-shortening with measurement of simple signal intensity ratio between the cochlea and brain parenchyma on 3D-FLAIR: correlation with T1 measurement by TI scout sequence
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 9:17-22. 2010
    ..We evaluated the feasibility of measuring simple signal intensity ratio by correlating rapid T(1) measurements using an inversion time (TI) scout sequence...
  27. doi request reprint Pathogenetic role of increased nasal resistance in obese patients with obstructive sleep apnea syndrome
    Mitsuhiko Tagaya
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan
    Am J Rhinol Allergy 24:51-4. 2010
    ..The role of increased nasal resistance in obstructive sleep apnea syndrome (OSAS) remains controversial. The aim of this study was to examine the pathogenetic role of nasal obstruction in obese patients with OSAS...
  28. doi request reprint Endothelin-1 gene polymorphism in sudden sensorineural hearing loss
    Yasue Uchida
    Department of Otorhinolaryngology, Aichi Medical University, Nagakute, Aichi, Japan Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan
    Laryngoscope 123:E59-65. 2013
    ..This study aimed to investigate the association between the Lys198Asn (G/T) polymorphism (rs5370) of the endothelin-1 gene and sudden sensorineural hearing loss (SSNHL)...
  29. doi request reprint Magnetic resonance imaging of the inner ear after both intratympanic and intravenous gadolinium injections
    Tatsuo Iida
    Department of Otorhinolaryngology, Nagoya University, Nagoya, Japan
    Acta Otolaryngol 133:434-8. 2013
    ..The MRI revealed a difference of intracochlear Gd distribution between the IT injection side and the contralateral IV side...
  30. ncbi request reprint Imaging of Ménière's disease by subtraction of MR cisternography from positive perilymph image
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 11:303-9. 2012
    ....
  31. pmc Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Ménière's disease in a Japanese population
    Masaaki Teranishi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    DNA Cell Biol 31:1555-62. 2012
    ..In conclusion, no significant associations between the polymorphisms of GPX1, PON1, PON2, and SOD2 and risk of SSNHL and Ménière's disease were observed in this Japanese case-control study...
  32. doi request reprint Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection
    Rui Sano
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Japan
    Acta Otolaryngol 132:241-6. 2012
    ..Using heavily T2-weighted 3D-FLAIR MRI, visualization of endolymphatic hydrops (EH) was possible in the vestibule and the cochlea after a standard intravenous dose of Gd...
  33. doi request reprint Contrast enhancement of the inner ear after intravenous administration of a standard or double dose of gadolinium contrast agents
    Hirokazu Suzuki
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Japan
    Acta Otolaryngol 131:1025-31. 2011
    ..Imaging of the endolymphatic space was possible in most cases after administering a standard dose of gadolinium (Gd) by using heavily T2-weighted 3D fluid-attenuated inversion recovery (hT(2)W-3D-FLAIR) magnetic resonance imaging (MRI)...
  34. doi request reprint Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with sudden sensorineural hearing loss
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Japan
    Laryngoscope 120:791-5. 2010
    ..To investigate the recently reported association of the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with sudden sensorineural hearing loss (SSNHL), we analyzed data from a community-based Japanese population...
  35. ncbi request reprint Blood flow in the ears of patients receiving cochlear implants
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Ann Otol Rhinol Laryngol 113:426-30. 2004
    ..In the patients with idiopathic progressive sensorineural hearing loss, the CBF was significantly lower in patients more than 40 years old. Intracochlear calcification following meningitis appears to be associated with a reduced CBF...
  36. ncbi request reprint Distribution of pendrin in the organ of Corti of mice observed by electron immunomicroscopy
    Takahiko Yoshino
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 4668550, Japan
    Eur Arch Otorhinolaryngol 263:699-704. 2006
    ..Our study revealed that pendrin occurs in the organ of Corti. The role of pendrin in the organ of Corti and its association with the Cl- or pH regulation of neurotransmission require further study...
  37. doi request reprint Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya, Japan
    Radiat Med 26:597-602. 2008
    ..The purpose of this study was to evaluate how frequently this occurs and to investigate the specific features of patients who lack this communication...
  38. ncbi request reprint Detection of presumed hemorrhage in the ampullar endolymph of the semicircular canal: a case report
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 8:187-91. 2009
    ..The 3D-FLAIR images demonstrated a small amount of focal hemorrhage in the labyrinthine fluid that may have been overlooked on T(1)-weighted images...
  39. doi request reprint Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo
    Masaaki Teranishi
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Eur Arch Otorhinolaryngol 266:1871-7. 2009
    ..In conclusion, 3T MRI after intratympanic injection of Gd-DTPA revealed endolymphatic hydrops both in the cochlea and in the vestibule in the patients with fluctuating hearing loss without vertigo...
  40. ncbi request reprint Individual differences in the permeability of the round window: evaluating the movement of intratympanic gadolinium into the inner ear
    Mayumi Yoshioka
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Otol Neurotol 30:645-8. 2009
    ..We used magnetic resonance imaging (MRI) to evaluate whether and how intratympanically administered gadolinium (Gd) enters the inner ear...
  41. doi request reprint Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Magn Reson Imaging 31:210-4. 2010
    ....
  42. ncbi request reprint Comparison of oxygen desaturation patterns in children and adults with sleep-disordered breathing
    Yuki Hara
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Japan
    Am J Otolaryngol 34:537-40. 2013
    ..We investigated differences in SDB patterns in children and adults to evaluate SDB severity in children...
  43. ncbi request reprint Visualization of endolymphatic hydrops in Ménière's disease with single-dose intravenous gadolinium-based contrast media using heavily T(2)-weighted 3D-FLAIR
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa, Nagoya, Japan
    Magn Reson Med Sci 9:237-42. 2010
    ..This technique can be implemented in a clinical setting...
  44. doi request reprint Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease
    Masahiro Kato
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 133:123-9. 2013
    ..Using an imaging method, we provide evidence that atypical Meniere's disease is a true variant of classic Meniere's disease...
  45. doi request reprint Peak width in multifrequency tympanometry and endolymphatic hydrops revealed by magnetic resonance imaging
    Ken Kato
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Otol Neurotol 33:912-5. 2012
    ....
  46. doi request reprint Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings and prognosis in sudden sensorineural hearing loss
    Tadao Yoshida
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 118:1433-7. 2008
    ..However, the relationship between 3D-FLAIR findings and hearing prognosis is unclear. Our objective was to evaluate the relationship between the results of 3D-FLAIR MRI at 3 Tesla and prognosis in sudden SNHL...
  47. doi request reprint Comparison of computed tomography and magnetic resonance imaging for evaluation of cholesteatoma with labyrinthine fistulae
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 122:1121-5. 2012
    ..To compare preoperative computed tomography (CT) and magnetic resonance imaging (MRI) findings to the clinical features in patients with middle ear cholesteatoma with labyrinthine fistulae...
  48. doi request reprint Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes
    Naoki Nishio
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gene 499:226-30. 2012
    ..214 (CI: 0.581-2.538) in nondiabetic subjects. We conclude that CFH Y402H polymorphism and SSNHL risk are significantly related, and that diabetic CFH Y402H minor allele carriers may be susceptible to SSNHL...
  49. ncbi request reprint Response of cochlear blood flow to prostaglandin E1 applied topically to the round window
    Mitsuo Tominaga
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Acta Otolaryngol 126:232-6. 2006
    ..The increase in cochlear blood flow (CBF) after administration of prostaglandin E1 (PGE1) to the round window depends on increased blood flow through the anterior inferior cerebellar artery (AICA)...
  50. doi request reprint Pharyngeal morphology: a determinant of successful nasal surgery for sleep apnea
    Mami Morinaga
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 119:1011-6. 2009
    ..To estimate the effectiveness of nasal surgery on the occurrence of sleep apnea, and to analyze the pharyngeal morphology of apnea patients whose sleep-disordered breathing was ameliorated postoperatively...
  51. doi request reprint Morphological examination of upper airway in obstructive sleep apnea
    Hidehito Yagi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Auris Nasus Larynx 36:444-9. 2009
    ..An aim of this study was to assess the predictive power of an otorhinolaryngological examination of the upper airway to identify risk factors of obstructive sleep apnea syndrome (OSAS) in the patients...
  52. ncbi request reprint Distortion product otoacoustic emissions and tympanometric measurements in an adult population-based study
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi, Japan
    Auris Nasus Larynx 33:397-401. 2006
    ....
  53. doi request reprint Significance of a screening device (Apnomonitor 5) for sleep apnea syndrome
    Hidehito Yagi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Showa, Aichi, Japan
    Auris Nasus Larynx 36:176-80. 2009
    ..The objective was to evaluate the significance of a portable sleep-monitoring device (Apnomonitor 5, Chest Co., Tokyo, Japan) to diagnose sleep apnea syndrome (SAS)...
  54. doi request reprint The Ala54Thr polymorphism in the fatty acid-binding protein 2 (FABP2) gene is associated with hearing impairment: a preliminary report
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu City, Aichi Prefecture 474 8511, Japan
    Auris Nasus Larynx 37:496-9. 2010
    ..The FABP2 gene has been proposed as a candidate gene for diabetes and obesity. This study evaluates the hearing impairment risk in the Ala54Thr polymorphism of FABP2 in middle-aged and elderly Japanese...
  55. doi request reprint Imaging analysis in cases with inflammation-induced sensorineural hearing loss
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 129:239-43. 2009
    ..3D-FLAIR imaging is sensitive to inflammatory inner ear disturbances and may be a useful method in investigating the severity of inner ear disturbance in cases of inflammation-induced SNHL...
  56. ncbi request reprint Hearing loss in patients with enlarged vestibular aqueduct: air-bone gap and audiological Bing test
    Tamie Mimura
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Int J Audiol 44:466-9. 2005
    ....
  57. doi request reprint The impact of arterial sclerosis on hearing with and without occupational noise exposure: a population-based aging study in males
    Mayumi Yoshioka
    Department of Otorhinolaryngology Cognitive and Speech Medicine, Nagoya University School of Medicine, 65 Tsuruma cho, Showa Ward, Nagoya City, Aichi Prefecture 466 8550, Japan
    Auris Nasus Larynx 37:558-64. 2010
    ....
  58. ncbi request reprint Signal alteration of the cochlear perilymph on 3 different sequences after intratympanic Gd-DTPA administration at 3 tesla: comparison of 3D-FLAIR, 3D-T1-weighted imaging, and 3D-CISS
    Masahiro Yamazaki
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Magn Reson Med Sci 9:65-71. 2010
    ....
  59. ncbi request reprint Detection of herpesvirus DNAs in perilymph obtained from patients with sensorineural hearing loss by real-time polymerase chain reaction
    Saiko Sugiura
    Department of Otolaryngology, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Laryngoscope 114:2235-8. 2004
    ....
  60. doi request reprint Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 133:35-41. 2013
    ..The present study showed that elevation of bone-conduction (BC) thresholds at low frequencies might be a characteristic audiometric finding in cases with otitis media with effusion (OME) with high pepsinogen (PG) concentrations...
  61. doi request reprint Continuous positive airway pressure intolerance associated with elevated nasal resistance is possible mechanism of complex sleep apnea syndrome
    Chie Nakazaki
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Sleep Breath 16:747-52. 2012
    ..However, the pathophysiology of CompSAS remains controversial...
  62. ncbi request reprint Imaging of Ménière's disease after intravenous administration of single-dose gadodiamide: utility of subtraction images with different inversion time
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 11:213-9. 2012
    ..Subtraction significantly improved the contrast noise ratio between endolymph and perilymph and the subjective visibility score for endolymphatic space. The 24 patients with the suspect of Ménière's disease were included...
  63. doi request reprint Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection
    Masahiro Yamazaki
    Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuroradiology 54:1161-9. 2012
    ....
  64. ncbi request reprint Imaging of endolymphatic and perilymphatic fluid after intravenous administration of single-dose gadodiamide
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 11:145-50. 2012
    ..We observed high signal of cochlear endolymph in 17 ears with cochlear endolymphatic hydrops but not 11 ears without cochlear endolymphatic hydrops...
  65. ncbi request reprint Blood flow measurements in the ears of patients receiving cochlear implants
    Tsutomu Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Ann Otol Rhinol Laryngol 111:998-1001. 2002
    ..We conclude that laser-Doppler flowmetry is both relatively safe and useful for measuring blood flow in the ears during cochlear implantation procedures...
  66. pmc Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu City, Aichi Prefecture 474 8511, Japan
    BMC Med Genet 12:35. 2011
    ..The aim of this study is to investigate the effects of the methionine synthase (MTR) A2756G and methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphisms on the risk of hearing impairment in middle-aged and elderly Japanese...
  67. doi request reprint Cochlear blood flow during occlusion and reperfusion of the anterior inferior cerebellar artery--effect of topical application of dexamethasone to the round window
    Hironao Otake
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Acta Otolaryngol 129:127-31. 2009
    ..Topical application of dexamethasone may support autoregulation of cochlear blood flow (CBF), although it had no direct effect on CBF...
  68. doi request reprint Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss
    Terukazu Mizuno
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Eur Arch Otorhinolaryngol 266:351-5. 2009
    ..CMV DNA was not detected in any of the patients with sudden SNHL or enlarged vestibular aqueduct-associated SNHL. The features of CMV-associated SNHL were more asymmetric than those of CMV-negative bilateral SNHL...
  69. doi request reprint Tinnitus and brain MRI findings in Japanese elderly
    Saiko Sugiura
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
    Acta Otolaryngol 128:525-9. 2008
    ..There is evidence of an inverse association between cerebral infarction and tinnitus in this study. The effects of cerebral infarction on tinnitus could be explained by a neurophysiological model of tinnitus...
  70. doi request reprint Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Japan
    Laryngoscope 119:938-43. 2009
    ..To investigate the association between the Lys198Asn (G/T) polymorphism (rs5370) in the endothelin-1 gene (EDN1) and hearing impairment in middle-aged and elderly Japanese...
  71. doi request reprint Effects of nasal surgery on sleep quality in obstructive sleep apnea syndrome with nasal obstruction
    Seiichi Nakata
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Am J Rhinol 22:59-63. 2008
    ..A prospective study was performed in OSAS patients who underwent isolated nasal surgery in a tertiary referral center...
  72. doi request reprint Contribution of 1425G/A polymorphism in protein kinase C-Eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu City, Aichi Prefecture, Japan
    J Neurogenet 25:82-7. 2011
    ....
  73. ncbi request reprint Cochlear modiolus and lateral semicircular canal in sudden deafness
    Ieda Maria Ishida
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Acta Otolaryngol 127:1157-61. 2007
    ..Reduced cochlear modiolus area and inner area of the lateral semicircular canal (LSCC) may be associated with insufficient maturation of the inner ear...
  74. ncbi request reprint Changes in cochlear blood flow due to endotoxin-induced otitis media
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Ann Otol Rhinol Laryngol 113:450-4. 2004
    ..The results showed a functional influence upon CBF by endotoxin-induced otitis media. The significance of prophylactic use of the drug is also discussed in regard to the effect on CBF following otitis media...
  75. ncbi request reprint 3D-FLAIR MRI findings in a patient with Ramsay Hunt syndrome
    Makoto Sugiura
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Acta Otolaryngol 127:547-9. 2007
    ..3D-FLAIR could be a useful diagnostic tool in the early stages of Ramsay Hunt syndrome...
  76. doi request reprint Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate
    Hirokazu Suzuki
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 131:130-5. 2011
    ..There was no morphological change in the stria vascularis after Gd-DTPA or Gd-DTPA-BMA was placed on the round window of guinea pigs...
  77. ncbi request reprint Prediction of gastroesophageal reflux in otitis media with effusion in adults
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Acta Otolaryngol 127:470-3. 2007
    ..The measurement of pepsinogen I (PGI) in middle-ear effusions (MEEs) and a questionnaire on the frequency symptoms of gastroesophageal reflux (GER) disease are tools that can be used to screen for the existence of GER...
  78. ncbi request reprint Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 7:85-91. 2008
    ..We evaluated whether 3D-FLAIR-VFL could replace 3D-FLAIR-CONV in detecting endolymphatic hydrops after intratympanic Gd-DTPA administration...
  79. ncbi request reprint Increased sensitivity to low concentration gadolinium contrast by optimized heavily T2-weighted 3D-FLAIR to visualize endolymphatic space
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Magn Reson Med Sci 9:73-80. 2010
    ....
  80. doi request reprint Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients
    Akihiro Terada
    Department of Otorhinolaryngology, Japanese Red Cross Nagoya Daiichi Hospital, 3 35 Michishita cho, Nakamura ku, Nagoya, Aichi 453 8511, Japan
    Eur Arch Otorhinolaryngol 268:429-35. 2011
    ..6%. SN-positive patients exhibited a tendency toward cancer recurrence. There were three cases of false negatives not conforming to the SN concept and their rate was 7.9%. Positive SN had a negative impact on patient survival...
  81. ncbi request reprint Inner ear hemorrhage in systemic lupus erythematosus
    Makoto Sugiura
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Laryngoscope 116:826-8. 2006
    ..This is the first published case of inner ear hemorrhage in a patient with SLE. Our findings suggest that inner ear hemorrhage is associated with hearing deterioration in some patients with SLE...
  82. doi request reprint Limitations of FDG-PET and FDG-PET with computed tomography for detecting synchronous cancer in pharyngeal cancer
    Hidenori Suzuki
    Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, Japan
    Arch Otolaryngol Head Neck Surg 134:1191-5. 2008
    ..Good results have been reported from the use of FDG-PET and FDG-PET/CT in staging head and neck SCC (HNSCC). An additional advantage is that both techniques are expected to prove useful in detecting synchronous cancer...
  83. doi request reprint Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma
    Masahiro Yamazaki
    Department of Radiology, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuroradiology 51:855-63. 2009
    ....
  84. ncbi request reprint Otoacoustic emissions, ear fullness and tinnitus in the recovery course of sudden deafness
    Ieda M Ishida
    Nagoya University Graduate School of Medicine, Department of Otorhinolaryngology, 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Auris Nasus Larynx 35:41-6. 2008
    ..This study aimed to investigate how the symptoms of ear fullness, tinnitus and otoacoustic emissions (OAE) change in relation to the recovery course of pure tone audiometry thresholds (PTA) in sudden deafness (SD)...
  85. ncbi request reprint Visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: comparison of 2D and 3D real inversion recovery imaging
    Shinji Naganawa
    Department of Radiology, Nagoya University, Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Magn Reson Med Sci 10:101-6. 2011
    ..This technique enables differentiation of bone and endo- and perilymph space on a single image but requires 15 min of scan time. Therefore, we compared it with 2D real IR, which is faster...
  86. doi request reprint 3D-FLAIR MRI in facial nerve paralysis with and without audio-vestibular disorder
    Seiichi Nakata
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 130:632-6. 2010
    ..This MRI technique may contribute to elucidation of the pathology of Ramsay Hunt syndrome and Bell's palsy...
  87. ncbi request reprint Histidine-containing phosphotransfer (HPt) signal transducers implicated in His-to-Asp phosphorelay in Arabidopsis
    T Suzuki
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Japan
    Plant Cell Physiol 39:1258-68. 1998
    ..It was thus suggested that the uncovered sensors-AHPs-ARRs lineups may play important roles in propagating environmental stimuli through the multistep His-Asp phosphorelay in Arabidopsis...
  88. ncbi request reprint Two types of putative nuclear factors that physically interact with histidine-containing phosphotransfer (Hpt) domains, signaling mediators in His-to-Asp phosphorelay, in Arabidopsis thaliana
    T Suzuki
    School of Agriculture, BioScience Center, Nagoya University, Chikusa ku, Nagoya, 464 8601 Japan
    Plant Cell Physiol 42:37-45. 2001
    ....
  89. ncbi request reprint Systematic mutational analysis revealing the functional domain organization of Escherichia coli nucleoid protein H-NS
    C Ueguchi
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Japan
    J Mol Biol 263:149-62. 1996
    ..This finding is also addressed with regard to a unique regulatory mechanism (i.e. silencing) for the bgl operon, which is partly mediated by H-NS...
  90. pmc Response regulators implicated in His-to-Asp phosphotransfer signaling in Arabidopsis
    A Imamura
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya 464, Japan
    Proc Natl Acad Sci U S A 95:2691-6. 1998
    ..In vivo and in vitro evidence that ARRs can function as phosphoaccepting response regulators was obtained by employing the Escherichia coli His-Asp phosphotransfer signaling system...
  91. ncbi request reprint Prevalence of self-perceived auditory problems and their relation to audiometric thresholds in a middle-aged to elderly population
    Yasue Uchida
    Department of Otorhinolaryngology, Chubu National Hospital, Obu, Aichi, Japan
    Acta Otolaryngol 123:618-26. 2003
    ....
  92. ncbi request reprint Tympanometric findings in patients with enlarged vestibular aqueducts
    Eisuke Sato
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Japan
    Laryngoscope 112:1642-6. 2002
    ....
  93. ncbi request reprint Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway
    T Suzuki
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Placenta 23:475-82. 2002
    ..Our findings also suggest that NEP/CD10 may play a functional role in the process of trophoblast differentiation...
  94. ncbi request reprint Molecular cloning of chicken vasoactive intestinal polypeptide receptor complementary DNA, tissue distribution and chromosomal localization
    N Kansaku
    Laboratory of Animal Physiology, School of Agricultural Sciences, Nagoya University, Chikusa, Nagoya, Japan 464 860
    Biol Reprod 64:1575-81. 2001
    ..Chicken VIPR shows high homology with mammalian type I VIPR but, in some part, possesses similarity of amino acid sequence. Expression of VIPR in various tissues supports diverse functions for VIP in the chicken...
  95. ncbi request reprint Simultaneous three-dimensional visualization of the intra-parotid facial nerve and parotid duct using a three-dimensional reversed FISP sequence with diffusion weighting
    Shinji Naganawa
    Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Magn Reson Med Sci 9:153-8. 2010
    ..We also present volumetric representation of the facial nerve and duct...
  96. ncbi request reprint Serial MR imaging studies in enlarged endolymphatic duct and sac syndrome
    Shinji Naganawa
    Department of Radiology, Nagoya University School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya 466 8550, Japan
    Eur Radiol 12:S114-7. 2002
    ..The finding that the EES volume and signal intensity vary dynamically independently of hearing is important for future research into the pathophysiology of hearing loss in this syndrome...
  97. doi request reprint Imaging findings in a case with cholesteatoma in complete aural atresia
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Otolaryngol 31:297-9. 2010
    ....
  98. pmc Changes in laryngeal sensation evaluated with a new method before and after radiotherapy
    Kikuko Ozawa
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Shouwa ku, Nagoya, Aichi 466 8550, Japan
    Eur Arch Otorhinolaryngol 267:811-6. 2010
    ..Laryngeal sensation recovered in most cases within 1 year after radiotherapy. The present study clearly demonstrates the deterioration of laryngeal sensation with radiotherapy...
  99. ncbi request reprint Contrast-enhanced MR imaging of the endolymphatic sac in patients with sudden hearing loss
    Shinji Naganawa
    Department of Radiology, Nagoya University School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya 466 8550, Japan
    Eur Radiol 12:1121-6. 2002
    ....
  100. ncbi request reprint Small cell carcinoma of the larynx treated with irinotecan and cisplatin
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Auris Nasus Larynx 33:223-5. 2006
    ..For the cure of the aggressive lethal behavior of this disease, chemotherapy with CPT-11 might be effective to improve median survival of patients with small cell carcinomas of the larynx...
  101. ncbi request reprint Obstructive sleep apnoea associated with congenital choanal atresia
    Seiichi Nakata
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Aichi, Japan
    J Laryngol Otol 119:209-11. 2005
    ..On the basis of these observations, we modified the diagnosis to obstructive sleep apnoea syndrome (OSAS) secondary to congenital choanal atresia...