A Nakao

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Biological significance of isolated tumor cells and micrometastasis in lymph nodes evaluated using a green fluorescent protein-tagged human gastric cancer cell line
    Hiroyuki Yokoyama
    Department of Surgery II, Nagoya University School of Medicine and Division of Oncological Pathology, Aichi Cancer Center Research Institute, Kanokoden, Chukisa ku, 464 8681 Nagoya, Japan
    Clin Cancer Res 12:361-8. 2006
  2. ncbi request reprint Clinical experiment of mutant herpes simplex virus HF10 therapy for cancer
    A Nakao
    Department of Surgery II, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Curr Cancer Drug Targets 7:169-74. 2007
  3. ncbi request reprint Extended radical resection versus standard resection for pancreatic cancer: the rationale for extended radical resection
    Akimasa Nakao
    Department of Surgery II, Nagoya University Hospital, Nagoyashi, Japan
    Pancreas 28:289-92. 2004
  4. ncbi request reprint Oncological problems in pancreatic cancer surgery
    Akimasa Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    World J Gastroenterol 12:4466-72. 2006
  5. ncbi request reprint Total pancreatectomy with segmental duodenectomy for benign or low-grade malignancy tumors of the whole pancreas
    Akimasa Nakao
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Hepatogastroenterology 50:912-4. 2003
  6. doi request reprint Pancreatic head resection with segmental duodenectomy for pancreatic neoplasms
    Akimasa Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan n
    J Hepatobiliary Pancreat Sci 17:788-91. 2010
  7. ncbi request reprint Indications and techniques of extended resection for pancreatic cancer
    Akimasa Nakao
    Department of Surgery II, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    World J Surg 30:976-82; discussion 983-4. 2006
  8. doi request reprint Correlation between radiographic classification and pathological grade of portal vein wall invasion in pancreatic head cancer
    Akimasa Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 255:103-8. 2012
  9. ncbi request reprint Oral HCFU for prevention of hepatic metastasis in an experimental colorectal carcinoma
    K Ito
    Department of Surgery II, School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550 Japan
    Anticancer Res 21:899-904. 2001
  10. ncbi request reprint AIS overexpression in advanced esophageal cancer
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Japan
    Clin Cancer Res 7:469-72. 2001

Collaborators

Detail Information

Publications144 found, 100 shown here

  1. ncbi request reprint Biological significance of isolated tumor cells and micrometastasis in lymph nodes evaluated using a green fluorescent protein-tagged human gastric cancer cell line
    Hiroyuki Yokoyama
    Department of Surgery II, Nagoya University School of Medicine and Division of Oncological Pathology, Aichi Cancer Center Research Institute, Kanokoden, Chukisa ku, 464 8681 Nagoya, Japan
    Clin Cancer Res 12:361-8. 2006
    ..Using this model, we investigated the effect of surgery and chemotherapy on the growth of early-phase metastasis formation in the lymph nodes...
  2. ncbi request reprint Clinical experiment of mutant herpes simplex virus HF10 therapy for cancer
    A Nakao
    Department of Surgery II, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Curr Cancer Drug Targets 7:169-74. 2007
    ..Also a trial for non-resectable pancreatic cancer being carried out on the basis of the above result has proved to be innocuous and has been in progress to assess the clinical benefit and enhance the potentiality of HF10 against cancer...
  3. ncbi request reprint Extended radical resection versus standard resection for pancreatic cancer: the rationale for extended radical resection
    Akimasa Nakao
    Department of Surgery II, Nagoya University Hospital, Nagoyashi, Japan
    Pancreas 28:289-92. 2004
    ..This clinical study was carried out to clarify the indications for extended radical resection for pancreatic carcinoma...
  4. ncbi request reprint Oncological problems in pancreatic cancer surgery
    Akimasa Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    World J Gastroenterol 12:4466-72. 2006
    ..Recent molecular-biological studies have clarified occult metastasis, micrometastasis and systemic disease in pancreatic cancer. Several oncological problems in pancreatic cancer surgery are discussed in the present review...
  5. ncbi request reprint Total pancreatectomy with segmental duodenectomy for benign or low-grade malignancy tumors of the whole pancreas
    Akimasa Nakao
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Hepatogastroenterology 50:912-4. 2003
    ..This is an easy, simple, safe and function-preserving operative procedure for benign or low-grade malignancy tumors of the whole pancreas...
  6. doi request reprint Pancreatic head resection with segmental duodenectomy for pancreatic neoplasms
    Akimasa Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan n
    J Hepatobiliary Pancreat Sci 17:788-91. 2010
    ..We have experienced 67 cases of pancreatic head resection with segmental duodenectomy (PHRSD) for benign or low-grade malignant tumor of the pancreatic head region. Here we introduce our operative technique for these 67 cases...
  7. ncbi request reprint Indications and techniques of extended resection for pancreatic cancer
    Akimasa Nakao
    Department of Surgery II, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    World J Surg 30:976-82; discussion 983-4. 2006
    ..This study was carried out to clarify the indications for extended resection, especially vascular resection, for pancreatic carcinoma...
  8. doi request reprint Correlation between radiographic classification and pathological grade of portal vein wall invasion in pancreatic head cancer
    Akimasa Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 255:103-8. 2012
    ..A retrospective study was performed to clarify the correlation between radiographic type of portal vein (PV) invasion and pathological grade of PV wall invasion, and their correlation with postoperative prognosis...
  9. ncbi request reprint Oral HCFU for prevention of hepatic metastasis in an experimental colorectal carcinoma
    K Ito
    Department of Surgery II, School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550 Japan
    Anticancer Res 21:899-904. 2001
    ..An animal experimental study was performed to clarify the preventive effect of oral HCFU (1-hexylcarbamoyl-5-fluorouracil) on hepatic metastasis...
  10. ncbi request reprint AIS overexpression in advanced esophageal cancer
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Japan
    Clin Cancer Res 7:469-72. 2001
    ..Moreover, high AIS gene expression was significantly associated with lymph node metastases in esophageal cancer (P = 0.0271). These results suggested that AIS may be useful as a marker for advanced esophageal cancer...
  11. ncbi request reprint Comparative study of theefficacy of removal of anti-ABO and anti-gal antibodies by double filtration plasmapheresis
    T Kobayashi
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Xenotransplantation 7:101-8. 2000
    ....
  12. ncbi request reprint Molecular detection of p16 promoter methylation in the serum of patients with esophageal squamous cell carcinoma
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Cancer Res 7:3135-8. 2001
    ..We have examined promoter hypermethylation of the p16 gene in esophageal squamous cell carcinoma (SCC) using methylation-specific PCR to detect tumor DNA in the serum...
  13. ncbi request reprint Normal hepatic hemodynamics during early postoperative period in recipients with adult live donor liver transplantation
    H Sugimoto
    Nagoya University, Nagoya, Japan
    Transplant Proc 39:160-5. 2007
    ..72 +/- 0.11 vs 0.62 +/- 0.04 on day 1 (P = .0326). In conclusion, we have shown "abnormal" hepatic hemodynamics in even those recipients without complications during the early postoperative period after LDLT...
  14. ncbi request reprint Overexpression of pituitary tumor transforming gene 1 in HCC is associated with angiogenesis and poor prognosis
    Tsutomu Fujii
    Department of Surgery II, Graduate School and Faculty of Medicine, Nagoya University, Nagoya, Japan
    Hepatology 43:1267-75. 2006
    ..PTTG1 is overexpressed in HCC and our results suggest that PTTG1 mRNA expression has prognostic significance for the survival of postoperative patients with HCC...
  15. ncbi request reprint Enhanced efficacy of herpes simplex virus mutant HF10 combined with paclitaxel in peritoneal cancer dissemination models
    S Shimoyama
    Department of Surgery II, Graduate School of Medicine Nagoya University, Nagoya, Japan
    Hepatogastroenterology 54:1038-42. 2007
    ..Further, we attempted to evaluate HF10/paclitaxel combination therapy...
  16. ncbi request reprint Pharmacodynamics induced by direct electric current for the treatment of 5-fluorouracil resistant tumor: an animal experiment
    K Ito
    Department of Surgery, School of Medicine, Nagoya University, Japan
    Int J Colorectal Dis 16:326-30. 2001
    ..This elevated 5-FU concentration in the tumor tissue is considered one of the reasons for the effective inhibition of 5-FU resistance in clinical cases...
  17. ncbi request reprint The role of extended radical operation for pancreatic cancer
    A Nakao
    Department of Surgery II, Nagoya University School of Medicine, 65 Tsurumaicho, Showa Ku, Nagoya 466 8550, Japan
    Hepatogastroenterology 48:949-52. 2001
    ..To clarify the indication of extended operation for pancreatic carcinoma, a clinical study was carried out...
  18. ncbi request reprint Mitochondrial DNA alteration in esophageal cancer
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Int J Cancer 92:319-21. 2001
    ..Although the mutation rate of mitochondrial tumor DNA within the D-loop was not high, this result suggested that mtDNA mutations play a role in the development of esophageal cancer...
  19. ncbi request reprint Suitability of a US3-inactivated HSV mutant (L1BR1) as an oncolytic virus for pancreatic cancer therapy
    H Kasuya
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Cancer Gene Ther 14:533-42. 2007
    ..These results suggest that L1BR1 is promising as a new anticancer oncolytic virus...
  20. doi request reprint Nonfunctioning neuroendocrine pancreatic tumors: our experience and management
    Naohiro Nomura
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    J Hepatobiliary Pancreat Surg 16:639-47. 2009
    ..We present our experience in the treatment of nonfunctioning neuroendocrine pancreatic tumors (NFNPTs) to define the clinical and pathological characteristics and to suggest proper management...
  21. pmc Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer
    S Nomoto
    Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya, Nagoya, Japan
    Br J Cancer 98:1690-5. 2008
    ..0143). Hypermethylation and LOH appear to be common mechanisms for inactivation of RUNX3 in pancreatic cancer. Therefore, RUNX3 may be an important tumour suppressor gene related to pancreatic cancer...
  22. pmc Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma
    S Nomoto
    Department of Surgery II, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Br J Cancer 97:1260-5. 2007
    ..From our findings, multicentric HCCs tend to occur more independently than metastatically from the original tumour. Expanded study should be pursued further for a better understanding of the molecular mechanism of hepatocarcinogenesis...
  23. ncbi request reprint Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer
    K Ito
    Second Department of Surgery, School of Medicine, Nagoya University, Japan
    J Gastroenterol 36:823-9. 2001
    ..The elevation of E-selectin alone or both E-selectin and sialyl Lewis A may be one of the useful indexes for more precise diagnosis of hematogenous metastases of human colorectal cancer...
  24. ncbi request reprint The role of adjuvant therapy for pancreatic cancer
    S Takeda
    Department of Surgery II, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hepatogastroenterology 48:953-6. 2001
    ..e., intraoperative radiotherapy and liver perfusion chemotherapy, to the radical resection. The aim of this study is to investigate the utility of these two forms of adjuvant therapy prospectively and to review their effectiveness...
  25. ncbi request reprint Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis
    Mitsuro Kanda
    Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya, Showa Ku, Nagoya, Japan
    Int J Oncol 35:477-83. 2009
    ..0978). Our results indicated that MT1G acts as a tumor suppressor gene in HCC. Moreover, findings suggested that the mechanisms of MT1G silencing are related to promoter hypermethylation...
  26. doi request reprint Value of peritoneal cytology in potentially resectable pancreatic cancer
    S Yamada
    Department of Gastroenterological Surgery Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Surg 100:1791-6. 2013
    ..Peritoneal lavage cytology (CY) is used in the diagnosis and staging of various cancers. The clinical significance of positive cytology results in patients with pancreatic cancer is yet to be determined...
  27. doi request reprint Antitumor efficacy of oncolytic herpes simplex virus adsorbed onto antigen-specific lymphocytes
    A Kanzaki
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Gene Ther 19:292-8. 2012
    ..In this context, herpes oncolytic virus is a promising treatment not only for primary lesions, but also for multiple metastasizing lesions. This treatment strategy may become one of the most effective methods for systemic virus delivery...
  28. ncbi request reprint Adenovirus-mediated gene transfer of CTLA4Ig gene results in prolonged survival of heart allograft
    S Hayashi
    Department of Surgery II, Nagoya University, School of Medicine, Japan
    Transpl Int 13:S329-32. 2000
    ..In conclusion, adenovirus-mediated gene transfer with CTLA4Ig gene was efficient for the prolongation of both transgene expression and allograft survival...
  29. ncbi request reprint PAI-1 expression levels in esophageal and colorectal cancers are closely correlated to those in corresponding normal tissues
    T Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:4343-7. 2006
    ..Taken together, PAI-1 overexpression in esophageal and colorectal cancers might originate from higher PAI-1 expression in corresponding normal tissues and result in a malignant phenotype of these cancers...
  30. ncbi request reprint Detection of mitochondrial DNA alterations in primary tumors and corresponding serum of colorectal cancer patients
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Int J Cancer 94:429-31. 2001
    ..Of 7 alterations that were examined, 1 (14%) could be detected in the serum. This result suggested that the mtDNA alteration could also be used as a tumor marker to detect tumor DNA in the serum...
  31. ncbi request reprint Surgical treatment of intraductal papillary-mucinous tumors of the pancreas
    N Kanazumi
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Hepatogastroenterology 48:967-71. 2001
    ..In cases with invasion, radical resection is required. On the other hand, organ-function-preserving procedures should be selected for diseases without invasion...
  32. ncbi request reprint Gene therapy for pancreatic cancer
    H Kasuya
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hepatogastroenterology 48:957-61. 2001
    ....
  33. ncbi request reprint Neuroendocrine-like differentiation in patients with pancreatic carcinoma
    E Tezel
    Department of Surgery II, Nagoya University, School of Medicine, Japan
    Cancer 89:2230-6. 2000
    ..The accurate estimation of the rate and the clinicopathologic significance of neuroendocrine-like differentiation (NED) in patients with pancreatic carcinoma have not been studied in detail...
  34. ncbi request reprint Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma
    Tomoki Fukuoka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 26:3333-5. 2006
    ..ESCC with methylation-positive genes showed a trend towards larger tumor size and deeper invasion (p = 0.139 and p = 0.0664, respectively). Thus, the methylation of the p16, HLTF and CDH13 genes is a high malignancy factor in ESCC...
  35. ncbi request reprint Methylation-mediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis
    Osamu Okochi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Clin Cancer Res 9:5295-8. 2003
    ..Recently, it was demonstrated that SOCS-1 gene was silenced frequently by methylation of CpG island in human hepatocellular carcinoma (HCC). We examined the methylation-mediated silencing of SOCS-1 in tumors of HCC patients...
  36. ncbi request reprint Efficacy of intraperitoneal chemotherapy with paclitaxel targeting peritoneal micrometastasis as revealed by GFP-tagged human gastric cancer cell lines in nude mice
    Norifumi Ohashi
    Department of Surgery II, Nagoya University School of Medicine, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Oncol 27:637-44. 2005
    ..These results indicate that intraperitoneal paclitaxel is effective against peritoneal metastasis in early phase...
  37. ncbi request reprint Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma
    Mitsuru Sakai
    Department of Surgery II, Graduate School of Medicine, Nagoya University, Japan
    Hepatogastroenterology 52:1854-7. 2005
    ..We examined the methylation status of the CHFR gene in primary hepatocellular carcinomas (HCCs) and evaluated the correlation between the methylation status and the malignancy of HCC...
  38. doi request reprint Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array
    Yukiyasu Okamura
    Department of Surgery II, Graduate School and Medicine, University of Nagoya, Nagoya 466 8550, Japan
    Cancer Lett 289:170-7. 2010
    ..0001). The present study suggests that our method is a meaning technique able to detect novel genes and that LIFR gene is a new suppressor gene of HCC...
  39. doi request reprint Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer
    T T Sahin
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Gene Ther 19:229-37. 2012
    ..HF10 seems to meet this criterion; furthermore, it induces potent antitumor immunity. The increase in angiogenesis may be due to either viral replication or the inflammatory response...
  40. ncbi request reprint Newly developed drug delivery system in cancer chemotherapy using direct electric current
    K Ito
    Department of Surgery II, Nagoya University School of Medicine, Japan
    ASAIO J 47:338-41. 2001
    ..05). Electric therapy using a slight direct current could gather anionized MTX to the cathode, while reducing MTX concentration in the serum of experimental rats...
  41. ncbi request reprint Reversal of portal flow after acute rejection in living-donor liver transplantation
    H Sugimoto
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
    J Hepatobiliary Pancreat Surg 8:573-6. 2001
    ..Hepatofugal flow after liver transplantation is considered to be an ominous sign caused by several factors, and its appearance indicates a fatal condition...
  42. ncbi request reprint Significance of transporter associated with antigen processing gene polymorphism in living related renal transplantation
    T Kobayashi
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Hum Immunol 61:670-4. 2000
    ..It also suggested that donor's antigen presenting cells with the TAP2*0103 allele would have the attenuated efficacy in the presentation of allospecific antigens to recipient's T cells...
  43. doi request reprint Pancreatic cancer with paraaortic lymph node metastasis: a contraindication for radical surgery?
    Suguru Yamada
    Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya, Nagoya, Japan
    Pancreas 38:e13-7. 2009
    ..The purpose of this study was to determine the operative indications for pancreatic cancer with paraaortic lymph node metastases (No. 16 [+])...
  44. ncbi request reprint Prognostic significance of intraperitoneal cancer cells in gastric carcinoma: detection of cytokeratin 20 mRNA in peritoneal washes, in addition to detection of carcinoembryonic antigen
    Yasuhiro Kodera
    Second Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gastric Cancer 8:142-8. 2005
    ..A search for other molecular markers is ongoing...
  45. ncbi request reprint Longterm outcomes of early-stage gastric carcinoma patients treated with laparoscopy-assisted surgery
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Coll Surg 206:138-43. 2008
    ..Laparoscopy-assisted approaches have become popular for dissecting early-stage gastric cancer in Japan, but the outcomes after 5 years of followup have not been reported...
  46. ncbi request reprint Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene increases the sensitivity of esophageal cancer cells to 5-fluorouracil
    H Nakamura
    Department of Surgery II, Nagoya University School of Medicine, Aichi, Japan
    Surg Today 31:785-90. 2001
    ..Therefore, we potentiated the effects of commercially available anticancer drugs by gene transduction. Our method may prove useful as a new form of cancer gene therapy in the future...
  47. ncbi request reprint Small incisional esophagectomy with endoscopic assistance: evaluation of a new technique
    S Akiyama
    Department of Surgery II, Nagoya University School of Medicine, Aichi, Japan
    Surg Today 31:378-82. 2001
    ..The postoperative courses of 20 consecutive patients who underwent this procedure were generally uneventful, and significant improvements in terms of intensive care and analgesic requirements were observed...
  48. ncbi request reprint Radical surgery for gastric carcinoma: it is not an issue of whether to perform D1 or D2. Dissect as many lymph nodes as possible and you will be rewarded
    E Kodera
    Department of Surgery II, Nagoya University School of Medicine, Showa, Nagoya, Aichi, Japan
    Acta Chir Belg 109:27-35. 2009
    ..Lymphadenectomy should no longer be considered only as a tool for cancer-staging, but also as a beneficial therapeutic measure...
  49. pmc Methylation pattern of CDH13 gene in digestive tract cancers
    K Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Br J Cancer 91:1139-42. 2004
    ..These results suggested that CDH13 might play a variety of roles depending on the tissue type...
  50. ncbi request reprint A phase II study of radical surgery followed by postoperative chemotherapy with S-1 for gastric carcinoma with free cancer cells in the peritoneal cavity (CCOG0301 study)
    Y Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Eur J Surg Oncol 35:1158-63. 2009
    ..A standard treatment for such patients remains to be established...
  51. doi request reprint A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer
    A Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Gene Ther 18:167-75. 2011
    ..The tumors were classified as stable disease in three patients, partial response in one patient and progressive disease in two patients...
  52. ncbi request reprint Intraoperative ultrasonography by high-resolution annular array transducer for intraductal papillary mucinous tumors of the pancreas
    T Kaneko
    Department of Surgery II, Faculty of Medicine, University of Nagoya, Nagoya, Japan
    Surgery 129:55-65. 2001
    ....
  53. ncbi request reprint Gene transfer with cationic lipid into human hepatocellular carcinoma in nude mice
    T Miwa
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Hepatogastroenterology 46:825-9. 1999
    ..Using a cationic lipid, gene transfection into the tumor of a human hepatocellular carcinoma model in nude mice was attempted in order to explore the possibility of its use in gene therapy...
  54. doi request reprint The tumor suppressor NPRL2 in hepatocellular carcinoma plays an important role in progression and can be served as an independent prognostic factor
    Satoshi Otani
    Department of Surgery II, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    J Surg Oncol 100:358-63. 2009
    ..In the current study, we aimed to evaluate NPRL2 expression in HCC and to explore the prognostic significance of NPRL2...
  55. ncbi request reprint Perioperative prostaglandin E1 treatment for the prevention of postoperative complications after esophagectomy: a randomized clinical trial
    Kazushige Oda
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Surg Today 34:662-7. 2004
    ..We conducted a prospective randomized clinical study to examine whether perioperative prostaglandin E1 (PGE1) could help in the prevention of postoperative complications after esophagectomy for esophageal cancer...
  56. ncbi request reprint Evaluation of the histoculture drug response assay as a sensitivity test for anticancer agents
    Satoshi Suda
    Second Department of Surgery, Nagoya University School of Medicine, Japan
    Surg Today 32:477-81. 2002
    ..To investigate whether the effects of anticancer agents are able to be predicted, the results of sensitivity tests on anticancer agents were compared with the results of preoperative chemotherapy...
  57. ncbi request reprint S100A2 overexpression is frequently observed in esophageal squamous cell carcinoma
    Masahiko Imazawa
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Anticancer Res 25:1247-50. 2005
    ..We identified S100A2, a Ca2+-binding protein, as a novel downstream mediator of deltaNp63...
  58. ncbi request reprint Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma
    Toshiaki Mori
    Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Liver Int 25:380-8. 2005
    ..RUNX3 locus 1p36 is commonly deleted in a variety of human cancers, including HCC. Therefore, we examined genetic and epigenetic alterations of RUNX3 in human HCC...
  59. pmc Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer
    Shigeki Nakayama
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Ann Surg 240:840-4. 2004
    ....
  60. ncbi request reprint Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients
    Shinichi Fujitake
    Gastrointestinal Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol 39:120-4. 2004
    ..To define the role of SOCS-1 in the tumorigenic pathway of the colorectum, we examined the methylation of SOCS-1 in tumors of colorectal cancer patients...
  61. ncbi request reprint Detection of p16 promoter hypermethylation in serum of gastric cancer patients
    Yasuaki Kanyama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Cancer Sci 94:418-20. 2003
    ..No methylation was found in serum DNA of these control groups. Our results suggest that p16 methylation would be a good marker for the detection of tumor DNA in the serum of primary gastric cancer patients...
  62. ncbi request reprint Plasminogen activator inhibitor-1 as a potential marker for the malignancy of esophageal squamous cell carcinoma
    Takumi Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Cancer Res 10:1375-8. 2004
    ....
  63. ncbi request reprint Gene expression profile of 5-fluorouracil metabolic enzymes in primary colorectal cancer: potential as predictive parameters for response to fluorouracil-based chemotherapy
    Mizunobu Kinoshita
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Anticancer Res 27:851-6. 2007
    ..Therapy guided by chemotherapy sensitivity and resistance assays may lead to rational treatment decisions...
  64. ncbi request reprint Oncolytic virus therapy--foreword
    H Kasuya
    Department of Surgery II, Nagoya University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Curr Cancer Drug Targets 7:123-5. 2007
    ..g., H101 has been tested in clinical trial of nearly 250 patients and approved for human use by the Chinese FDA, while PV701 has been tried in over 110 patients, as described in our special issue)...
  65. ncbi request reprint Intraoperative diagnosis of pancreatic cancer extension using IVUS
    T Kaneko
    Department of Surgery II, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
    Hepatogastroenterology 48:944-8. 2001
    ..Intraportal endovascular ultrasonography could also diagnose the extrapancreatic nerve plexus invasion of segment II...
  66. ncbi request reprint Correlation between copy number of mitochondrial DNA and clinico-pathologic parameters of hepatocellular carcinoma
    S Yamada
    Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Eur J Surg Oncol 32:303-7. 2006
    ..In the current study, we investigated possible correlations of the mtDNA copy number in hepatocellular carcinoma (HCC) with the pathological findings and prognosis...
  67. doi request reprint Effect of sonoporation on cationic liposome-mediated IFNbeta gene therapy for metastatic hepatic tumors of murine colon cancer
    S Hayashi
    Department of Neurosurgery, Nagoya University, Graduate School of Medicine, 65 Tsurumai, corrected Showa ku, Nagoya, Japan
    Cancer Gene Ther 16:638-43. 2009
    ..In conclusion, ultrasound-mediated gene therapy for the treatment of hepatic cancers may be effective in a clinical setting...
  68. ncbi request reprint Delayed rupture of a pseudoaneurysm following pancreatoduodenectomy: report of a case
    H Sugimoto
    Second Department of Surgery, Nagoya University School of Medicine, Japan
    Surg Today 31:932-5. 2001
    ..To our knowledge, this case represents the longest interval between pancreatoduodenectomy and rupture of a pseudoaneurysm ever to be reported in the literature...
  69. ncbi request reprint PAI-1 expression levels in gastric cancers are closely correlated to those in corresponding normal tissues
    Takumi Sakakibara
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tusrumai cho, Showa Ku, Nagoya 466 8560, Japan
    Hepatogastroenterology 55:1480-3. 2008
    ..To investigate the mechanism of PAI-1 overexpression in gastric cancers, the PAI-1 expression levels in gastric cancers were compared to those in the corresponding normal tissues...
  70. ncbi request reprint Para-aortic lymph node metastasis in carcinoma of the head of the pancreas
    Mitsuru Sakai
    Department of Surgery II, Nagoya University School of Medicine, Showa Ku, Nagoya, Japan
    Surgery 137:606-11. 2005
    ..Metastasis to para-aortic lymph nodes often occurs in pancreatic head cancer, but factors that predict it are not well known...
  71. ncbi request reprint Correlations of the expression of vascular endothelial growth factor B and its isoforms in hepatocellular carcinoma with clinico-pathological parameters
    Mitsuro Kanda
    Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya, Nagoya, Japan
    J Surg Oncol 98:190-6. 2008
    ..We investigated correlations of the expression of VEGF-B and its isoforms, VEGF-B167 and VEGF-B186, by alternative splicing in hepatocellular carcinoma (HCC) with the pathological findings and prognosis...
  72. ncbi request reprint Molecular detection of circulating esophageal squamous cell cancer cells in the peripheral blood
    Masahiko Koike
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Clin Cancer Res 8:2879-82. 2002
    ....
  73. ncbi request reprint Aberrant methylation of the CHFR gene in digestive tract cancer
    Yuki Morioka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:1791-5. 2006
    ..Recently, aberrant methylation of the CHFR gene associated with gene silencing has been reported in several cancers. The methylation status of the CHFR gene was examined in primary esophageal and gastric carcinomas...
  74. ncbi request reprint [Clinical significance of isolated tumor cells and micrometastases in patients with gastric carcinoma]
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gan To Kagaku Ryoho 34:817-23. 2007
    ..In this review,the authors describe the relevance of micrometastases detected in various body components of patients with gastric cancer, and propose how the information thus obtained could be reflected in the treatment strategy...
  75. ncbi request reprint Reduction of alpha-galactosyl xenoantigen by expression of endo-beta-galactosidase C in pig endothelial cells
    Haruko Ogawa
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan
    Xenotransplantation 9:290-6. 2002
    ....
  76. ncbi request reprint Effects of tumor selective replication-competent herpes viruses in combination with gemcitabine on pancreatic cancer
    Izuru Watanabe
    Department of Surgery II, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Chemother Pharmacol 61:875-82. 2008
    ..The combination of one of two representative mutant herpes simplex viruses (R3616: gamma(1)34.5 inactivated, hrR3: UL39 inactivated) with a standard anti-pancreatic cancer chemotherapy drug (gemcitabine), was investigated in this study...
  77. ncbi request reprint Prognostic significance of intraperitoneal cancer cells in gastric carcinoma: analysis of real time reverse transcriptase-polymerase chain reaction after 5 years of followup
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Coll Surg 202:231-6. 2006
    ..A reverse transcriptase-polymerase chain reaction (RT-PCR) technique amplifying carcinoembryonic antigen mRNA was recently introduced to detect these cells more sensitively...
  78. ncbi request reprint Potential value of high-dose mizoribine as rescue therapy for ongoing acute humoral rejection
    DaGe Liu
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Transpl Int 18:401-7. 2005
    ..However, leukocytopenia was observed when MZ trough level was maintained over 10 mug/ml. Treatment with high-dose MZ would be applicable to a clinical trial, if blood level is carefully monitored...
  79. ncbi request reprint Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer
    Tamotsu Inoue
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8560, Japan
    J Gastroenterol 40:143-7. 2005
    ..To avoid unnecessary medication and uncomfortable side effects, it is important to estimate the chemosensitivity of cancers to 5-fluorouracil (5-FU) before chemotherapy...
  80. ncbi request reprint TNF-alpha promotes progression of peritoneal metastasis as demonstrated using a green fluorescence protein (GFP)-tagged human gastric cancer cell line
    Yoshinari Mochizuki
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Exp Metastasis 21:39-47. 2004
    ....
  81. ncbi request reprint Extended lymph node dissection in gastric carcinoma: where do we stand after the Dutch and British randomized trials?
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    J Am Coll Surg 195:855-64. 2002
  82. ncbi request reprint Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer
    Mitsuru Sakai
    Department of Surgery II, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Cancer Sci 95:588-91. 2004
    ..Our results suggest that the aberrant methylation of CDH13 occurs frequently in pancreatic cancer, even at a relatively early stage...
  83. ncbi request reprint The effect of chemotherapy against micrometastases and isolated tumor cells in lymph nodes: an in vivo study
    Takehiko Eguchi
    Department of Surgery II, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    In Vivo 22:707-12. 2008
    ..An in vivo model was established in which a gastric cancer cell line, GCIY-EGFP, metastasizes spontaneously to the lymph nodes when inoculated subcutaneously...
  84. ncbi request reprint Pedicle myocutaneous flaps for reconstruction following total pelvic exenteration of intrapelvic recurrent rectal cancer: report of a case
    H Ando
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Surg Today 31:363-6. 2001
    ..In this report, we examine the effectiveness of using the gracilis muscle for PMF in intrapelvic and perineal reconstruction after TPE...
  85. doi request reprint Pretransplant pharmacodynamic analysis of immunosuppressive agents using CFSE-based T-cell proliferation assay
    Y Kurata
    Department of Clinical Pharmacy, College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan
    Clin Pharmacol Ther 86:285-9. 2009
    ..In addition to post-transplant blood-level monitoring, pretransplant pharmacodynamics could provide useful information on optimal and safe immunosuppressive therapy...
  86. pmc Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
    T Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Japan
    Br J Cancer 93:799-803. 2005
    ..0432). These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC...
  87. ncbi request reprint Expression of HLA-DR in intrahepatic cholangiocarcinoma
    A Torii
    Department of Surgery II, Nagoya University, School of Medicine, Japan
    Cancer 70:1057-61. 1992
    ..Based on these results, the presence or absence of HLA-DR on tumor cells could have a pathologic significance for intrahepatic cholangiocarcinoma...
  88. ncbi request reprint Critical progressive small-graft injury caused by intrasinusoidal pressure elevation following living donor liver transplantation
    H Sugimoto
    Department of Surgery II, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Transplant Proc 36:2750-6. 2004
    ..These changes were not observed in the biopsy obtained soon after reperfusion. In conclusion, critically decreased vascular beds may cause intrasinusoidal pressure elevation and sinusoidal circulatory disturbances...
  89. ncbi request reprint The use of quantitative Doppler ultrasonography to predict posthepatectomy complications on the basis of hepatic hemodynamic parameters
    Hiroyuki Sugimoto
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Surgery 132:431-40. 2002
    ..Doppler ultrasonography assesses hepatic hemodynamics noninvasively. This study uses hepatic hemodynamic parameters to predict posthepatectomy complications...
  90. ncbi request reprint Plasminogen activator inhibitor-1 as a potential marker for the malignancy of gastric cancer
    Takumi Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Cancer Sci 97:395-9. 2006
    ..0450). These results suggested that PAI-1 might serve as a new and promising parameter for the prediction of prognosis in gastric cancer...
  91. ncbi request reprint Quantitative analysis of Doppler waveform of hepatic veins for assessment of hepatic functional reserve
    Kenji Oshima
    Department of Surgery II, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Hepatogastroenterology 54:180-5. 2007
    ..The analysis of the Doppler waveform of hepatic veins might be a useful and non-invasive method to assess hepatic functional reserve and the amount of the liver to be excised...
  92. ncbi request reprint Debate: extended resection for pancreatic cancer; the affirmative case
    Akimasa Nakao
    Second Department of Surgery, Nagoya Unversity Hospital, Nagoya, Japan
    J Hepatobiliary Pancreat Surg 10:57-60. 2003
    ..A clinical study was carried out to clarify the indications for extended resection of pancreatic cancer...
  93. ncbi request reprint Enzymatic removal of alphaGal antigen in pig kidneys by ex vivo and in vivo administration of endo-beta-galactosidase C
    DaGe Liu
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Xenotransplantation 9:228-36. 2002
    ..Alternatively, transgenic techniques of introducing the gene for EndoGalC into the donor organ might permanently prevent alphaGal expression...
  94. ncbi request reprint [Extended radical resection for pancreatic head cancer]
    Shin Takeda
    Department of Surgery II, Nagoya University Graduate School of Medicine
    Nihon Rinsho 64:96-100. 2006
  95. ncbi request reprint Adrenal incidentaloma: review of 197 patients and report of a drug-related false-positive urinary normetanephrine result
    Takahiro Ito
    Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Surg Today 36:961-5. 2006
    ..To determine the incidence and importance of functioning tumors among incidentally discovered adrenal masses in the era of laparoscopic surgery...
  96. ncbi request reprint Laparoscopy-assisted distal gastrectomy with systemic lymph node dissection for early gastric carcinoma: a review of 43 cases
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University School of Medicine, Nagoya Aichi, Japan
    J Am Coll Surg 196:75-81. 2003
    ..But the use of this approach in gastric carcinoma has received little attention, possibly from the low incidence of early-stage disease in the West and the relative complexity of the surgical procedure...
  97. ncbi request reprint Telomerase activity as prognostic factor in gastrointestinal stromal tumors of the stomach
    Jun Kawai
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya University Hospital, Nagoya, Japan
    Hepatogastroenterology 52:959-64. 2005
    ..Telomerase activity, often detected in malignant tumors, may have a role as a marker for high-grade malignancy...
  98. ncbi request reprint Laparoscopy-assisted distal gastrectomy with systemic lymph node dissection: a phase II study following the learning curve
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University School of Medicine, Nagoya Aichi, Japan
    J Surg Oncol 91:26-32. 2005
    ..A preliminary study on the use of laparoscopy-assisted approach to treat gastric carcinoma resulted in higher morbidity...
  99. ncbi request reprint Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor
    Tsutomu Fujii
    Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Hepatol 41:104-11. 2004
    ..In the current study, we aimed to evaluate focal adhesion kinase (FAK), a non-receptor tyrosine kinase, expression in hepatocellular carcinoma (HCC), and to explore the prognostic significance of FAK...
  100. ncbi request reprint Images of interest. Hepatobiliary and pancreatic: the color bar sign after living donor liver transplantation
    H Sugimoto
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 20:318. 2005