Research Topics
Genomes and Genes | Mamoru NakanishiSummaryAffiliation: Nagoya City University Country: Japan Publications
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Detail Information
Publications
Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cellsT Amano
Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
J Biochem 129:739-44. 2001..1+/-0.02 microm/s. This shows that the granules are able to reach the plasma membranes in 2 or 3 min if the diameter of the cells is 20 microm...- Confocal and probe microscopy to study gene transfection mediated by cationic liposomes with a cationic cholesterol derivativeM Nakanishi
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Adv Drug Deliv Rev 52:197-207. 2001..In addition we found that microtubules were involved in the intracellular dynamics of gene transfection... - New strategy in gene transfection by cationic transfection lipids with a cationic cholesterolMamoru Nakanishi
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Curr Med Chem 10:1289-96. 2003.... - NBD-conjugated biosurfactant (MEL-A) shows a new pathway for transfectionYoshinobu Ueno
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
J Control Release 123:247-53. 2007..Thereafter, the oligonucleotide released from the vesicles was immediately transferred to the nucleus. The present results showed a new role of non-viral vectors in transfection... - Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cellsNaoto Kato
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
J Immunol 177:147-54. 2006..These results suggest that flotillin-1 is an essential molecule in IgE receptor-mediated mast cell activation, and regulates the kinase activity of Lyn in lipid rafts... - Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cellsSatomi Chikamatsu
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Mol Immunol 44:1490-7. 2007..This finding gives a new insight into the role of Cot in the FcvarepsilonRI-mediated NF-kappaB activation in mast cells... - The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nervesTadahide Furuno
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
J Immunol 174:6934-42. 2005..At points of contact between neurites and wild-type BMMC, SgIGSF/SynCAM was locally concentrated in both neurites and BMMC. SgIGSF/SynCAM on mast cells appeared to predominantly mediate attachment and promote communication with nerves... - Complexin II facilitates exocytotic release in mast cells by enhancing Ca2+ sensitivity of the fusion processSatoshi Tadokoro
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
J Cell Sci 118:2239-46. 2005.... - Anchoring cationic amphiphiles for nucleotide delivery: significance of DNA release from cationic liposomes for transfectionNaohide Hirashima
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Biol Pharm Bull 30:1117-22. 2007..Thus, the efficiency of release of DNA from cationic liposomes in the cytoplasm, which contributes to high transfection efficiency, appears to be dependent upon the molecular shape of the cationic amphiphiles... - Asialoganglioside enhances the efficiency of gene transfection mediated by cationic liposomes with a cationic cholesterol derivativeShoichiro Noguchi
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
Biol Pharm Bull 26:1306-10. 2003..Together with the results obtained by luciferase assay mentioned above, the removal of sialic acid from ganglioside causes the enhancement of efficiency of transfection mediated by cationic liposomes... - Calcium response and FcepsilonRI expression in bone marrow-derived mast cells co-cultured with SCG neuritesAkio Suzuki
Graduate School of Pharmaceutical Sciences, Nagoya City University; Nagoya 467-8603, Japan
Biol Pharm Bull 28:1963-5. 2005..All of these results indicated that co-culturing BMMCs with SCG neurites for 3 d promoted not only the calcium response but also the FcepsilonRI expression in BMMCs... - Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cellsFumio Kawamura
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Biol Pharm Bull 33:881-5. 2010.... 
Inhibition of degranulation and cytokine production in bone marrow-derived mast cells by hydrolyzed rice branYuka Hoshino
Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Japan
Inflamm Res 59:615-25. 2010..We investigated the effects of hydrolyzed rice bran (HRB), an arabinoxylan extracted from rice bran, on mast cell degranulation and cytokine production...- Characterization of biosurfactant-containing liposomes and their efficiency for gene transfectionYoshinobu Ueno
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Biol Pharm Bull 30:169-72. 2007..The results indicated that these kinds of the physicochemical properties in MEL-A-containing liposomes are able to increase the efficiency of liposome-mediated gene transfection... - Complexin II regulates degranulation in RBL-2H3 cells by interacting with SNARE complex containing syntaxin-3Satoshi Tadokoro
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Cell Immunol 261:51-6. 2010..These results suggest that complexin II regulates degranulation by interacting with the SNARE complex containing syntaxin-3... - ATP plays a role in neurite stimulation with activated mast cellsRyo Suzuki
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
J Neuroimmunol 192:49-56. 2007.... - Neurotrophic factors increase tumor necrosis factor-alpha-induced nuclear translocation of NF-kappaB in rat PC12 cellsTadahide Furuno
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori
Neurosci Lett 392:240-4. 2006.... - Latrotoxin-induced exocytosis in mast cells transfected with latrophilinHiroyuki Hiramatsu
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Toxicon 56:1372-80. 2010..Our study may provide a new system to investigate the action of α-LTX and the mechanism of exocytosis in mast cells... - Remarkable induction of apoptosis in cancer cells by a novel cationic liposome complexed with a bcl-2 antisense oligonucleotideShoichiro Noguchi
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Japan
J Control Release 88:313-20. 2003..The results showed the possibility that this new cationic cholesterol derivative might be very promising to be used for liposome-mediated gene targeting in vitro and in vivo... - Cholesterol depletion inhibits store-operated calcium currents and exocytotic membrane fusion in RBL-2H3 cellsNaoto Kato
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
Biochemistry 42:11808-14. 2003..These results suggest that cholesterol depletion by MbetaCD decreases degranulation mainly by inhibiting the SOC and membrane fusion between the secretory granules and the plasma membrane in mast cells... - Munc18-2 regulates exocytotic membrane fusion positively interacting with syntaxin-3 in RBL-2H3 cellsSatoshi Tadokoro
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Mol Immunol 44:3427-33. 2007.... - Biosurfactant MEL-A dramatically increases gene transfection via membrane fusionYoshikazu Inoh
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
J Control Release 94:423-31. 2004..This suggests that MEL-A induces the membrane fusion between the target cells and the cationic liposomes, accelerating the efficiency of gene transfection dramatically... - Transbilayer asymmetry of phospholipids in the plasma membrane regulates exocytotic release in mast cellsNaoto Kato
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
Biochemistry 41:8068-74. 2002..This finding also demonstrates that the transbilayer asymmetry of phospholipids regulates exocytosis and gives a new insight into the significance of lipid asymmetry in the plasma membrane... - Activation of receptor tyrosine kinases promotes gene transfection in rat neuronal PC12 cells by cationic liposomesAri Noguchi
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan
Neurosci Lett 325:29-32. 2002..It is supposed that the novel liposomes with the derivative (I) will be useful to study the problems in neuron and neuronal tissues for gene transfection... - Live cell imaging to study signaling molecules in allergic reactionsTadahide Furuno
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Biol Pharm Bull 28:1551-9. 2005.... - N-cadherin plays a role in the synapse-like structures between mast cells and neuritesAkio Suzuki
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
Biol Pharm Bull 27:1891-4. 2004..In addition, we found that the synapse-like structure was assisted by clustering of beta-catenin to N-cadherin... - Effects of 2-methyl-1,4-naphtoquinone (menadione) on cellular signaling in RBL-2H3 cellsFumio Kawamura
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Japan
Biol Pharm Bull 29:605-7. 2006..These results suggest that reactive oxygen generated inside RBL cells by menadione inhibited degranulation by decreasing Ca2+ influx through the store operated Ca2+ channel on the plasma membrane... - The effects of ITIM-bearing FcgammaRIIB on the nuclear shuttling of MAP kinase in RBL-2H3 cellsNobuyuki Ohyama
Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
Immunol Lett 90:173-6. 2003..This suggested that the co-clustering negatively control the production of pro-inflammatory cytokines through the suppression of nuclear shuttling of ERK2... - [Functional fluctuation]Mamoru Nakanishi
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Yakugaku Zasshi 126:379-93. 2006..This new theme is pretty well supported by our recent experiments for neuro-immune crosstalk, gene transfection with cationic liposomes, and cell signaling in embryonic stem cells... - Role of mu-calpain in human decidua for recurrent miscarriageKyoko Kumagai
Department of Obstetrics and Gynecology, Nagoya City University, Mizuho ku, Nagoya, Japan
Am J Reprod Immunol 59:339-46. 2008..In the present study, we investigated the existence and distribution of calpains, calpastatin, integrin beta3 and alpha-fodrin in decidua from patients with recurrent miscarriage... - The plasma membrane shuttling of CAPRI is related to regulation of mast cell activationRika Nakamura
Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Japan
Biochem Biophys Res Commun 347:363-8. 2006..The results suggested that the translocation of CAPRI to the plasma membranes regulates crucially cellular responses in mast cells... - Comparative study of transfection efficiency of cationic cholesterols mediated by liposomes-based gene deliverySeiji Hasegawa
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, 467-8603, Nagoya, Japan
Bioorg Med Chem Lett 12:1299-302. 2002..We also found that the introduction of a hydrophilic group to the amino terminal of the cholesterol derivative decreased stability and facilitated the release of DNA from the endosome, resulting in higher transfection efficiency... - Conditioned medium from feeder STO cells increases the attachment of mouse embryonic stem cellsKenichiro Amano
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
Biol Pharm Bull 29:1747-50. 2006..In addition, from present experiments we found that the dish double-coated with gelatin and CM was extremely useful for culturing ES cells... - Effect of NeuroD2 expression on neuronal differentiation in mouse embryonic stem cellsYasutaka Sugimoto
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Cell Biol Int 33:174-9. 2009..The results suggest that the expression of NeuroD2 requires an appropriate period of about 3 days to elicit neuronal differentiation in ES cells... - Phosphorylation states of STAT3 and ERKs in mouse embryonic stem cellsSakiko Miyazu
Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuhoku, Nagoya, Japan
Cell Biol Int 34:485-92. 2010..These results suggested that LIF-induced SOCS3 suppressed the ERKs activation pathway in undifferentiated ES cells, and the down-regulation of SOCS3 by the removal of LIF triggered the phosphorylation of ERKs... - Bone marrow-derived mast cells in mice respond in co-culture to scorpion venom activation of superior cervical ganglion neurites according to level of expression of NK-1 receptorsTadahide Furuno
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Neurosci Lett 372:185-9. 2004..Our findings show that the expression of NK-1 receptors appears to be important for nerve-mast cell communication... - Cationic cholesterol promotes gene transfection using the nuclear localization signal in protamineAri Noguchi
Graduate School of Pharmaceutical Sciences. Nagoya City University, Nagoya, Japan
Pharm Res 19:933-8. 2002.... - Molecular basis of neuroimmune interaction in an in vitro coculture approachMamoru Nakanishi
School of Pharmacy, Aichi Gakuin University, 1 100 Kusumoto cho, Chikusa ku, Nagoya 464 8650, Japan
Cell Mol Immunol 5:249-59. 2008..It would lead to new therapeutic modalities for diseases based on neuroimmune interaction such as neurogenic inflammation, intestinal bowel diseases, asthma, and autoimmune disorders... - The ratio of serum paraoxonase/arylesterase activity using an improved assay for arylesterase activity to discriminate PON1(R192) from PON1(Q192)Mamoru Nakanishi
Department of Clinical Pathology, Hyogo College of Medicine, Hyogo, Japan
J Atheroscler Thromb 10:337-42. 2003..Therefore, when conducting epidemiological or mechanistic studies that examine the role of PON1 in organophosphorus or lipid metabolism, this ratio is more useful and informative than a PCR-based genotype alone...