T Nabeshima

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction
    M H Tran
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Psychiatry 8:407-12. 2003
  2. ncbi request reprint Animal model of schizophrenia: dysfunction of NMDA receptor-signaling in mice following withdrawal from repeated administration of phencyclidine
    Toshitaka Nabeshima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    Ann N Y Acad Sci 1086:160-8. 2006
  3. ncbi request reprint The role of nociceptin in cognition
    T Nabeshima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain Res 848:167-73. 1999
  4. ncbi request reprint Potentiation in phencyclidine-induced serotonin-mediated behaviors after intracerebroventricular administration of 5,7-dihydroxytryptamine in rats
    T Nabeshima
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    J Pharmacol Exp Ther 243:1139-46. 1987
  5. ncbi request reprint Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptors
    A Noda
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuropsychopharmacology 24:451-60. 2001
  6. doi request reprint Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice
    P Lu
    Department of Chemical Pharmacology, Meijo University, Nagoya, Japan
    J Pharmacol Exp Ther 331:319-26. 2009
  7. ncbi request reprint SKF-10,047 reverses stress-induced motor suppression: interaction with dopaminergic system
    H Kamei
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Eur J Pharmacol 260:39-46. 1994
  8. ncbi request reprint Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-alpha gene: implications for emotional behavior
    K Yamada
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, 466 8560, Nagoya, Japan
    J Neuroimmunol 111:131-8. 2000
  9. ncbi request reprint Memory deficits and increased emotionality induced by beta-amyloid (25-35) are correlated with the reduced acetylcholine release and altered phorbol dibutyrate binding in the hippocampus
    A Olariu
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    J Neural Transm 108:1065-79. 2001
  10. pmc Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor
    T Mamiya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsurama-cho, Showa-ku, Nagoya 466-8560, Japan
    Br J Pharmacol 132:1111-7. 2001

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction
    M H Tran
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Psychiatry 8:407-12. 2003
    ..Our findings suggest that the tyrosine nitration of synaptophysin is related to Abeta-induced impairment of ACh release...
  2. ncbi request reprint Animal model of schizophrenia: dysfunction of NMDA receptor-signaling in mice following withdrawal from repeated administration of phencyclidine
    Toshitaka Nabeshima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    Ann N Y Acad Sci 1086:160-8. 2006
    ..Our PCP-treated mice would be a useful model for studying the effect of antipsychotics on emotional and cognitive deficits in schizophrenia...
  3. ncbi request reprint The role of nociceptin in cognition
    T Nabeshima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain Res 848:167-73. 1999
    ..In addition, the antagonists for the nociceptin receptor may be worth testing for alleviating memory disorders...
  4. ncbi request reprint Potentiation in phencyclidine-induced serotonin-mediated behaviors after intracerebroventricular administration of 5,7-dihydroxytryptamine in rats
    T Nabeshima
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    J Pharmacol Exp Ther 243:1139-46. 1987
    ..These results may indicate that PCP as a 5-HT2 agonist induces head-twitch via 5-HT2 receptors, and that PCP induces head-weaving and turning via 5-HT1 receptors and/or some other mechanisms in rats...
  5. ncbi request reprint Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptors
    A Noda
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuropsychopharmacology 24:451-60. 2001
    ..These results suggest that PCP induces an impairment of latent learning, this effect being mediated via glutamatergic systems, and that activation of sigma(1) receptors ameliorates impairment of latent learning induced by PCP...
  6. doi request reprint Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice
    P Lu
    Department of Chemical Pharmacology, Meijo University, Nagoya, Japan
    J Pharmacol Exp Ther 331:319-26. 2009
    ..These findings suggest that silibinin (i) attenuates memory impairment through amelioration of oxidative stress and inflammatory response induced by Abeta(25-35) and (ii) may be a potential candidate for an AD medication...
  7. ncbi request reprint SKF-10,047 reverses stress-induced motor suppression: interaction with dopaminergic system
    H Kamei
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Eur J Pharmacol 260:39-46. 1994
    ..These results suggest that stress-induced motor suppression is restored by (+/-)-SKF-10,047 acting through sigma receptors, which are closely linked to the dopaminergic neuronal system...
  8. ncbi request reprint Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-alpha gene: implications for emotional behavior
    K Yamada
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, 466 8560, Nagoya, Japan
    J Neuroimmunol 111:131-8. 2000
    ..These findings suggest a role for endogenous TNF-alpha in emotional behavior, which may possibly be related to alterations of serotonine metabolism...
  9. ncbi request reprint Memory deficits and increased emotionality induced by beta-amyloid (25-35) are correlated with the reduced acetylcholine release and altered phorbol dibutyrate binding in the hippocampus
    A Olariu
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    J Neural Transm 108:1065-79. 2001
    ..Our results suggest that the amnesic and anxiogenic effects of chronic infusion of beta-amyloid (25-35) are related to the decreased acetylcholine release and reduced PKC activation...
  10. pmc Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor
    T Mamiya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsurama-cho, Showa-ku, Nagoya 466-8560, Japan
    Br J Pharmacol 132:1111-7. 2001
    ..Furthermore, rolipram may be a useful drug for attenuating the development of morphine dependence...
  11. ncbi request reprint Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice
    T Mamiya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, 466 8560, Nagoya, Japan
    Neuropharmacology 39:2391-8. 2000
    ..Further, the ameliorating effects of (+) SKF 10,047 on the impairment of spontaneous alternation behavior may be mediated through activation of guanylate cyclase, but not nitric oxide synthase in the hippocampus of mice...
  12. ncbi request reprint (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress through the activation of phenytoin-regulated sigma 1 sites
    H Kamei
    Department of Chemical Pharmacology, Meijo University, Nagoya, Japan
    Eur J Pharmacol 299:21-8. 1996
    ..These results suggest that activation of phenytoin-regulated type sigma 1 receptors, but not of phencyclidine receptors, is involved in the ameliorating effects of (+)-SKF-10,047 and dextromethorphan on stress-induced motor suppression...
  13. ncbi request reprint Morphine tolerance and dependence in the nociceptin receptor knockout mice
    T Mamiya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neural Transm 108:1349-61. 2001
    ..Furthermore, it is demonstrated that morphine withdrawal syndrome excepting jumping can be induced by naloxone benzoylhydrazone without any changes in the cyclic AMP levels in the thalamus...
  14. ncbi request reprint In vivo functional interaction between phencyclidine binding sites and sigma receptors to produce head-weaving behavior in rats
    K Kitaichi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Showa Ku, Japan
    Eur J Pharmacol 318:205-11. 1996
    ..o.). These results suggest that PCP binding sites and sigma receptors are involved in PCP-induced head weaving behavior, and that sigma1 receptors play an important role in modulation of the head-weaving behavior...
  15. ncbi request reprint Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats
    K Yamada
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Neurosci Lett 118:128-31. 1990
    ..These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease...
  16. ncbi request reprint Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptors
    T Mamiya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Psychiatry 8:752-65. 2003
    ..These results suggest that nociceptin system negatively modulates learning and memory through the regulation of NMDA receptor function and the expression of N-CAM...
  17. ncbi request reprint Effects of metaphit on phencyclidine and serotonin2 receptors
    T Nabeshima
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Neurosci Lett 102:303-8. 1989
    ..These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites...
  18. ncbi request reprint Sigma receptor ligands (+)-SKF10,047 and SA4503 improve dizocilpine-induced spatial memory deficits in rats
    L B Zou
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan
    Eur J Pharmacol 355:1-10. 1998
    ..These results suggest that the interaction of sigma1 receptors with NMDA receptors modulates spatial memory in rats...
  19. ncbi request reprint Interaction between enkephalinergic and dopaminergic systems in stressful situations
    A Katoh
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Eur J Pharmacol 193:95-9. 1991
    ..These results suggest that the attenuation of conditioned suppression of motility induced by activation of the [Met5]enkephalinergic system may be related to the striatal DAergic system...
  20. ncbi request reprint Role of (+)-SKF-10,047-sensitive sub-population of sigma 1 receptors in amelioration of conditioned fear stress in rats: association with mesolimbic dopaminergic systems
    H Kamei
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Eur J Pharmacol 319:165-72. 1997
    ....
  21. pmc Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice
    P Lu
    Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, 150 Yagotoyama, Tempaku ku, Nagoya, Japan
    Br J Pharmacol 157:1270-7. 2009
    ..In the present study, we examined the effect of silibinin on the memory impairment and accumulation of oxidative stress induced by Abeta(25-35) in mice...
  22. ncbi request reprint Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats
    J He
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neural Transm 108:1435-43. 2001
    ..These results suggest that OA causes spatial memory impairment and neurodegeneration when injected directly into the hippocampus. Our findings also indicate dissociation between memory impairment and neurodegeneration induced by OA...
  23. ncbi request reprint Phencyclidine and genetic animal models of schizophrenia developed in relation to the glutamate hypothesis
    T Enomoto
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Methods Find Exp Clin Pharmacol 29:291-301. 2007
    ..These findings suggest that PCP and genetic animal models would be useful for evaluating novel therapeutic candidates and for confirming pathological mechanisms of schizophrenia...
  24. ncbi request reprint (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated sigma 1 sites
    H Kamei
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Eur J Pharmacol 309:149-58. 1996
    ..These results suggest that the stress-induced motor suppression is restored by the activation of dopaminergic neuronal systems as a result of the stimulation of phenytoin-regulated type sigma 1 receptors...
  25. ncbi request reprint The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice
    K Yamada
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan
    J Pharmacol Exp Ther 276:460-6. 1996
    ..Further, it is suggested that the NO/cyclic GMP system may play a role in spatial working memory...
  26. ncbi request reprint Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit
    Y Miyamoto
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    J Neurosci 21:750-7. 2001
    ..In addition, our findings suggest that GluRepsilon1 mutant mice are useful as an animal model of psychosis that is associated with NMDA receptor malfunction and hyperfunction of dopaminergic and serotonergic neuronal systems...
  27. ncbi request reprint Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma(1) receptors
    A Mori
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Behav Brain Res 119:33-40. 2001
    ..In addition, the PCP-like discriminative stimulus effects of (+)-SKF-10047 were demonstrated to be mediated via PCP binding sites...
  28. ncbi request reprint Phencyclidine-induced head-weaving observed in mice after ritanserin treatment
    T Nabeshima
    Department of Chemical Pharmacology, Meijo University, Nagoya, Japan
    Eur J Pharmacol 139:171-8. 1987
    ..These results indicate that PCP induces head-weaving by interacting with a 5-HT receptor (possibly of the 5-HT1 subtype) indirectly after 5-HT release and induces head-twitch by interacting with 5-HT2 receptors directly...
  29. ncbi request reprint A role played by sigma receptors in the conditioned suppression of motility in mice
    T Nabeshima
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Psychopharmacology (Berl) 94:515-20. 1988
    ..The present behavioral and receptor-binding experiments suggest that the activation of nervous system mediated by sigma receptors may be responsible for the attenuation of conditioned suppression of motility...
  30. ncbi request reprint Characteristics of muscarinic cholinergic, gamma-aminobutyric acid(A) and phencyclidine receptors in spontaneously epileptic rats; in vitro quantitative autoradiographic analysis
    K Murase
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Neurosci Lett 131:1-4. 1991
    ..These results suggest that hyperfunction of mACh receptors in the striatum is involved in the appearance of absence-like seizures and tonic convulsion of SER...
  31. ncbi request reprint Neurosteroids ameliorate conditioned fear stress: an association with sigma receptors
    Y Noda
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    Neuropsychopharmacology 23:276-84. 2000
    ..Further, the endogenous DHEAS may be involved in the expression of conditioned fear stress response in mice...
  32. ncbi request reprint Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment
    H Qiao
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Meijo University, Japan
    Neuroreport 12:11-5. 2001
    ....
  33. ncbi request reprint [Effect of naftidrofuryl oxalate (LS-121) on experimental amnesia model in rats]
    T Kameyama
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Nihon Yakurigaku Zasshi 92:241-50. 1988
    ..Furthermore, it is suggested that LS-121 may also have a therapeutic effect on Alzheimer's disease, since it showed a tendency to improve the BF lesion-induced amnesia...
  34. ncbi request reprint Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation
    M Mizuno
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Mol Psychiatry 8:217-24. 2003
    ..Chronic treatment with PI3-K inhibitor wortmannin impaired spatial learning. Our findings suggested that activation of TrkB/PI3-K and protein synthesis signaling pathway by BDNF in the hippocampus is important for spatial memory...
  35. ncbi request reprint Changes in muscarinic cholinergic, PCP, GABAA, D1, and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats
    T Nabeshima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan
    Life Sci 55:1585-93. 1994
    ..These results suggest that uneven changes in receptors for various neurotransmitters throughout the brain may be responsible for the decline of brain function in aged rats...
  36. ncbi request reprint Phencyclidine-induced head-weaving and head-twitch through interaction with 5-HT1 and 5-HT2 receptors in reserpinized rats
    K Yamaguchi
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Neuropharmacology 26:1489-97. 1987
    ....
  37. ncbi request reprint Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice
    Y Noda
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    J Biol Chem 273:18047-51. 1998
    ..These results clearly suggest that the nociceptin system takes part in the physiological regulation of nociceptive thresholds but not in the basal modulation of locomotion...
  38. ncbi request reprint Naftidrofuryl oxalate, nootropic effects on the scopolamine- and the basal forebrain lesion-induced amnesia in rats
    S Ogawa
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences Meijo University, Nagoya, Japan
    Pharmacol Biochem Behav 39:997-1002. 1991
    ....
  39. ncbi request reprint Involvement of serotonergic neuronal systems in the anti-amnesic action of naftidrofuryl oxalate
    T Nabeshima
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Eur J Pharmacol 205:55-61. 1991
    ..42 x 10(-7) M), but did not inhibit that of [3H]serotonin to 5-HT1 receptors. These results suggest that naftidrofuryl oxalate may attenuate cycloheximide- and 5-HTP-induced amnesia by blocking 5-HT2 receptor subtypes...
  40. ncbi request reprint Effect of naftidrofuryl oxalate on 5-HT2 receptors in mouse brain: evaluation based on quantitative autoradiography and head-twitch response
    T Nabeshima
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Eur J Pharmacol 223:109-15. 1992
    ..These results suggest that LS-121 inhibits 5-HTP plus pargyline-induced head twitches by blocking 5-HT2 receptors...
  41. ncbi request reprint Difference in toxicity of beta-amyloid peptide with aging in relation to nerve growth factor content in rat brain
    T Fukuta
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    J Neural Transm 108:221-30. 2001
    ..NGF levels in the hippocampus were increased only in adult rats. These results suggest that Abeta is toxic only in the matured adult brain, and that the mechanism of toxicity is related to NGF synthesis...
  42. doi request reprint Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization
    X Cen
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Psychiatry 13:349, 451-63. 2008
    ..Piccolo C2A domain may act as a cytoskeletal regulator for plasmalemmal DAT internalization, which may underlie its contributions in behavioral plasticity...
  43. ncbi request reprint Effects of benzodiazepines on passive avoidance response and latent learning in mice: relationship to benzodiazepine receptors and the cholinergic neuronal system
    T Nabeshima
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    J Pharmacol Exp Ther 255:789-94. 1990
    ....
  44. ncbi request reprint Different effects of ethylketocyclazocine on phencyclidine- and N-allylnormetazocine-induced stereotyped behaviors in rats
    M Hiramatsu
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Pharmacol Biochem Behav 28:489-94. 1987
    ..EKC failed to affect the enhancing effect of SKF 10,047 on PCP-induced turning and backpedalling. These results suggest that part of the PCP- and SKF 10,047-induced stereotypy may be mediated by different neuronal mechanisms...
  45. ncbi request reprint Antinociceptive activity induced by tizanidine and alpha 2-adrenoreceptors
    T Nabeshima
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Neuropharmacology 26:1453-5. 1987
    ..These results indicate that the antinociceptive action induced by tizanidine may be mediated by alpha 2-adrenoreceptors...
  46. ncbi request reprint [Neuropharmacological effects of sigma receptor ligands: anxiolytic, anti-amnesic and neuroprotective effects]
    M Amano
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 16:73-84. 1996
    ..The present review describes the neuropharmacological effects of sigma receptor ligands, especially anxiolytic (anti-stress) effects, ameliorating effects on impairment of learning and memory, and neuroprotective effects...
  47. ncbi request reprint Effects of repeated administration of (-)-nicotine on AF64A-induced learning and memory impairment in rats
    M Hiramatsu
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Tenpaku ku, Nagoya, Japan
    J Neural Transm 109:361-75. 2002
    ..These results suggested that (-)-nicotine may have neuroprotective effects against the neurotoxicity induced by AF64A...
  48. ncbi request reprint Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle
    K Yamada
    Department of Chemical Pharmacology, Faculty of Pharmaceutial Sciences, Meijo University, Nagoya, Japan
    J Pharmacobiodyn 14:351-5. 1991
    ..These results suggest that continuous infusion of QA is a useful technique for the study of chronic neurodegenerative diseases associated with memory impairment...
  49. ncbi request reprint Prophylaxis of local vascular graft infection with levofloxacin incorporated into albumin-sealed dacron graft (LVFX-ALB Graft)
    T Osada
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Aichi, Japan
    Microbiol Immunol 43:317-21. 1999
    ..Therefore, LVFX-ALB presumably had a bactericidal action and adhesive prevention against inoculated S. aureus. LVFX-ALB may be useful in preventing graft infections during and immediately after vascular reconstruction...
  50. ncbi request reprint [The mechanisms of morphine dependence and it's withdrawal syndrome: study in mutant mice]
    Y Noda
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65, Tsuruma cho, Showaku, Nagoya 466 8560, Japan
    Nihon Yakurigaku Zasshi 117:21-6. 2001
    ....
  51. ncbi request reprint Enhancement of immobility induced by repeated phencyclidine injection: association with c-Fos protein in the mouse brain
    M Abdel-Naby Sayed
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8560, Japan
    Behav Brain Res 124:71-6. 2001
    ..These results suggest that increased c-Fos protein is involved in the expression of PCP-induced enhancement of immobility, and c-Fos expression plays a role in negative symptoms-like behavioral changes...
  52. ncbi request reprint Effects of dietary vegetable oils on behavior and drug responses in mice
    T Kameyama
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan
    Biol Pharm Bull 19:400-4. 1996
    ....
  53. ncbi request reprint [Sigma-receptor ligands and anti-stress actions]
    Y Noda
    Department of Neuropsychopharmacology, Nagoya University Graduate School of Medicine, Japan
    Nihon Yakurigaku Zasshi 114:43-9. 1999
    ....
  54. ncbi request reprint Effect of AD-5423 on animal models of schizophrenia: phencyclidine-induced behavioral changes in mice
    T Nagai
    Department of Neuropsychopharmacology, Nagoya University Graduate School of Medicine, Japan
    Neuroreport 14:269-72. 2003
    ..These findings suggest that AD-5423 would be clinically effective against both the positive and negative symptoms of schizophrenia...
  55. ncbi request reprint Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice
    T Mamiya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466, Japan
    Brain Res 783:236-40. 1998
    ..These results suggest that nociceptin receptor plays an important role in spatial attention by regulating the dopaminergic system in the brain...
  56. ncbi request reprint Reinforcing effects of morphine are reduced in tissue plasminogen activator-knockout mice
    Y Yan
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Neuroscience 146:50-9. 2007
    ..Our findings suggest that the reinforcing effects of morphine are reduced in tPA knockout mice. Modulation of the tPA system in the brain may be a potential target against drugs of abuse...
  57. ncbi request reprint Molecular mechanism of cholinergic dysfunction and cognitive deficits induced by amyloid beta-peptide
    M H Tran
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8560 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 21:125-32. 2001
    ..Moreover, proposed mechanisms for A beta-induced neurotoxicity such as oxidative stress, ion-channel formation, and A beta-receptor interaction are discussed...
  58. ncbi request reprint Absorption of cyclosporine (Neoral) from a microemulsion formulation in a living donor liver transplant recipient
    Y Maeda
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Transplant Proc 34:2784-7. 2002
  59. ncbi request reprint [Neuroactive steroid and stress response]
    T Nagai
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, 466-8560 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 21:157-62. 2001
    ....
  60. ncbi request reprint Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-alpha gene
    R Iida
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    FASEB J 14:1023-31. 2000
    ..These findings directly support a role for TNF-alpha in the neurodegenerative processes associated with viral infections such as HIV-1...
  61. ncbi request reprint Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors
    T Shiotani
    Department of Neuropsychopharmacology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    Brain Res 859:255-61. 2000
    ....
  62. doi request reprint Population pharmacokinetic analysis of vancomycin in patients with gram-positive infections and the influence of infectious disease type
    M Yamamoto
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine 65, Showa Ku, Nagoya, Japan
    J Clin Pharm Ther 34:473-83. 2009
    ..To describe the population pharmacokinetics of vancomycin in patients with gram-positive infections and to investigate the influence of type of infectious disease...
  63. ncbi request reprint Distribution and serum concentration of sisomicin released from fibrin glue-sealed dacron graft in the rat and human
    T Osada
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Tsuruma cho Showa ku, Nagoya, 466 8560, Japan
    J Biomed Mater Res 52:53-7. 2000
    ..The results of these clinical applications are in close correlation with those of the animal experiment and suggest that FG is useful as a carrier of SISO, allowing its controlled release for the prevention of local infection...
  64. ncbi request reprint Abnormalities of sensory and memory functions in mice lacking Bsg gene
    K Naruhashi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Showa Ku, Japan
    Biochem Biophys Res Commun 236:733-7. 1997
    ..These findings are consistent with the expression profile of basigin in the central nervous system. Thus, basigin may play an important role in learning and memory as well as in the sensory functions...
  65. doi request reprint Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice
    Daisuke Ibi
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 105:921-32. 2008
    ....
  66. ncbi request reprint Involvement of a dysfunctional dopamine-D1/N-methyl-d-aspartate-NR1 and Ca2+/calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine
    Akihiro Mouri
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Pharmacol 71:1598-609. 2007
    ..These findings indicate that repeated PCP treatment impairs latent learning through a prefrontal cortical dysfunction of NMDA-CaMKII signaling, which is associated with dopaminergic hypofunction...
  67. ncbi request reprint Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model
    Akihiro Mouri
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    FASEB J 21:2135-48. 2007
    ..Taken together, these results suggest that immunotherapy with AAV/Abeta is a safe and effective treatment for AD...
  68. doi request reprint Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25-35)
    Hiroko Tsunekawa
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8560, Japan
    Behav Brain Res 190:224-32. 2008
    ..These results suggest that selegiline potentiates the effect of donepezil on the cognitive impairment, and that the synergistic effect may be mediated through both the cholinergic and dopaminergic systems...
  69. ncbi request reprint Synergistic effect of galantamine with risperidone on impairment of social interaction in phencyclidine-treated mice as a schizophrenic animal model
    Dayong Wang
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan Japanese Society of Pharmacopoeia, Tokyo 150 0002, Japan
    Neuropharmacology 52:1179-87. 2007
    ....
  70. ncbi request reprint Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system
    Mina Ito
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 101:1392-9. 2007
    ..These results suggest that PAR-1 is a target for the tPA-plasmin system in the regulation of acute morphine-induced dopamine release in the NAc...
  71. ncbi request reprint Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety
    Dayong Wang
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Behav Brain Res 178:262-73. 2007
    ....
  72. ncbi request reprint Tumor necrosis factor-alpha and its inducer inhibit morphine-induced rewarding effects and sensitization
    Minae Niwa
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    Biol Psychiatry 62:658-68. 2007
    ..In this study, we investigated the effects of TNF-alpha or Leu-Ile on morphine (MOR)-induced rewarding effects and sensitization...
  73. ncbi request reprint Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuroreport 17:1453-7. 2006
    ..These results suggest that extracellular signal-regulated kinase 1/2 activation in the hippocampus plays a crucial role in spatial working memory...
  74. ncbi request reprint The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    J Neurosci 26:12374-83. 2006
    ..Targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of nicotine dependence...
  75. ncbi request reprint The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes
    Reiko Kuno
    Department of Neuroimmunology, Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Brain Res 1116:12-8. 2006
    ..These results suggest that an autocrine loop involving TNF-alpha contributes to the production of neurotrophic factors in response to inflammation...
  76. ncbi request reprint Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex
    Jin Hyeong Jhoo
    Department of Psychiatry, Pundang Jesaeng Hospital, Daejin Medical Center, Seongnam, South Korea
    Behav Brain Res 155:185-96. 2004
    ..Therefore, our results suggest that the oxidative stress contributes to the Abeta (1-42)-induced learning and memory deficits in mice...
  77. ncbi request reprint Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 100:1579-88. 2007
    ..These results suggest that both MMP-2 and MMP-9 play a crucial role in METH-induced behavioural sensitization and reward by regulating METH-induced dopamine release and uptake in the NAc...
  78. ncbi request reprint A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Abeta(25-35)
    Tursun Alkam
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Behav Brain Res 180:139-45. 2007
    ..These results demonstrated that the memory protective effects of RA in the neurotoxicity of Abeta(25-35) is due to its scavenging of ONOO(-), and that daily consumption of RA may protect against memory impairments observed in AD...
  79. ncbi request reprint Neuropsychotoxicity of abused drugs: involvement of matrix metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced behavioral sensitization and reward in rodents
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pharmacol Sci 106:9-14. 2008
    ..The MMP/TIMP system may be involved in METH-induced sensitization and reward by regulating extracellular dopamine levels...
  80. doi request reprint Restraining tumor necrosis factor-alpha by thalidomide prevents the amyloid beta-induced impairment of recognition memory in mice
    Tursun Alkam
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Behav Brain Res 189:100-6. 2008
    ..These results suggested the practicability of targeting TNF-alpha as a preventive strategy against Abeta-mediated cognitive impairments...
  81. ncbi request reprint [Behavioral evaluation in animal models of schizophrenia]
    Yukihiro Noda
    Nihon Yakurigaku Zasshi 130:117-23. 2007
  82. ncbi request reprint Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment
    Akihiro Mouri
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Neurochem Int 51:173-84. 2007
    ..Many findings suggest that these PCP animal models would be useful for evaluating novel therapeutic candidates and for confirming pathological mechanisms of schizophrenia...
  83. ncbi request reprint Synergistic effect of combined treatment with risperidone and galantamine on phencyclidine-induced impairment of latent visuospatial learning and memory: Role of nAChR activation-dependent increase of dopamine D1 receptor-mediated neurotransmission
    Dayong Wang
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Neuropharmacology 53:379-89. 2007
    ....
  84. doi request reprint Discontinuation of donepezil for the treatment of Alzheimer's disease in geriatric practice
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Int Psychogeriatr 20:800-6. 2008
    ..In the current study we surveyed the discontinuation of donepezil, a cholinesterase inhibitor, for the treatment of Alzheimer's disease in a Japanese geriatric outpatient clinic in a university hospital...
  85. ncbi request reprint [Behavioral analysis for spatial working memory in rats with a delayed spatial win-shift task in a radial arm maze]
    Taku Nagai
    Nihon Yakurigaku Zasshi 129:457-62. 2007
  86. ncbi request reprint Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens
    Ayumi Fukakusa
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 105:436-44. 2008
    ....
  87. ncbi request reprint Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Psychopharmacology (Berl) 194:21-32. 2007
    ..Although chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans, there are few reports about an animal model that reflects METH-induced impairment of working memory...
  88. ncbi request reprint Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implications for dopamine receptor down-regulation and dopamine release
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 102:1548-60. 2007
    ..These results suggest that the MMP/TIMP system is involved in METH-induced behavioral sensitization and reward, by regulating dopamine release and receptor signaling...
  89. ncbi request reprint Hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and NMDA-CaMKII signaling
    Rina Murai
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    Behav Brain Res 180:152-60. 2007
    ....
  90. ncbi request reprint Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment
    Makoto Takahashi
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Neurochem 99:770-80. 2006
    ..This study suggests that phencyclidine exposure during brain development induces sustained BDNF up-regulation in the limbic system with a biological link to sensorimotor gating deficits...
  91. ncbi request reprint Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds
    Yijin Yan
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Behav Brain Res 173:39-46. 2006
    ..These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse...
  92. ncbi request reprint Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function
    Shu Ming Huang
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 281:17941-51. 2006
    ..This supports the idea that a strategy to reduce Abeta oligomers in the brain by up-regulating neprilysin activity would contribute to alleviation of these symptoms...
  93. ncbi request reprint A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase
    Xiuhai Ren
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65, Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    Behav Brain Res 152:243-50. 2004
    ....
  94. ncbi request reprint Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice
    Eun Joo Shin
    Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Chunchon 200 701, South Korea
    Behav Brain Res 151:267-76. 2004
    ....
  95. ncbi request reprint Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity
    Akira Nakajima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    J Neurosci 24:2212-25. 2004
    ....
  96. ncbi request reprint Enhanced antidepressant efficacy of sigma1 receptor agonists in rats after chronic intracerebroventricular infusion of beta-amyloid-(1-40) protein
    Alexandre Urani
    INSERM U 336, Behavioural Neuropharmacology Group, Institut de Biologie, 4, bvd Henri IV, 34060 Montpellier, France
    Eur J Pharmacol 486:151-61. 2004
    ..The present study suggests that sigma(1) receptor agonists, due to their enhanced efficacy in a nontransgenic animal model, may alleviate Alzheimer's disease-associated depressive symptoms...
  97. ncbi request reprint Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit
    Yoshiaki Miyamoto
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    Eur J Neurosci 19:151-8. 2004
    ..These findings provide genetic evidence that GluRepsilon1 subunit-containing NMDA receptors are involved in certain aspects of drug addiction...
  98. ncbi request reprint Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients
    Takafumi Kuzuya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Showa Ku, Nagoya, Japan
    Transplantation 76:865-8. 2003
    ..We have investigated the role of these polymorphisms in CsA absorption from kidney transplant recipients. In addition, we also investigated the effect of amlodipine on CsA absorption...
  99. ncbi request reprint Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier
    Tomitsune Kitagami
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Nagoya 466, Japan
    Brain Res 978:104-14. 2003
    ..As a result, nitric oxide induced by the intramuscular injection of IFN-alpha was found to cross the blood-brain barrier and suppress both tetrahydrobiopterin biosynthesis and dopamine production in the amygdala and raphe areas...
  100. pmc Involvement of BDNF receptor TrkB in spatial memory formation
    Makoto Mizuno
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Learn Mem 10:108-15. 2003
    ..The phosphorylation of Fyn and NR2B, but not TrkB, was diminished by PP2 treatment. Our findings suggest the importance of interaction between BDNF/TrkB signaling and NMDA receptors for spatial memory in the hippocampus...
  101. ncbi request reprint Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase C
    Ana Olariu
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    Brain Res 957:278-86. 2002
    ..Our data indicate that chronic accumulation of beta-amyloid (1-40) into the rat brain reduced activation of PKC, effect that would substantially contribute to the memory deficit found in these animals...