Takashi Muramatsu

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Protein-bound carbohydrates on cell-surface as targets of recognition: an odyssey in understanding them
    T Muramatsu
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Glycoconj J 17:577-95. 2000
  2. ncbi request reprint Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis
    Takashi Muramatsu
    Department of Biochemistry, Nagoya University School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    J Biochem 132:359-71. 2002
  3. ncbi request reprint Development. Carbohydrate recognition in spermatogenesis
    Takashi Muramatsu
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Science 295:53-4. 2002
  4. ncbi request reprint Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion
    T Muramatsu
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Histol Histopathol 18:981-7. 2003
  5. ncbi request reprint [Function and medical significance of a growth factor, midkine]
    Takashi Muramastu
    Tanpakushitsu Kakusan Koso 47:1259-67. 2002
  6. ncbi request reprint alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor
    Hisako Muramatsu
    Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 117:5405-15. 2004
  7. ncbi request reprint ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity
    Guo Yun Chen
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa, Nagoya 466 8550, Japan
    Gene 340:71-81. 2004
  8. ncbi request reprint Demonstration of the pleiotrophin-binding oligosaccharide sequences isolated from chondroitin sulfate/dermatan sulfate hybrid chains of embryonic pig brains
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, 4 19 1, Motoyama kita machi, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 280:35318-28. 2005
  9. ncbi request reprint Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells
    Sen Chen
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 120:4009-15. 2007
  10. ncbi request reprint Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion
    Waichi Sato
    Department of Clinical Immunology of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 67:1330-9. 2005

Detail Information

Publications96

  1. ncbi request reprint Protein-bound carbohydrates on cell-surface as targets of recognition: an odyssey in understanding them
    T Muramatsu
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Glycoconj J 17:577-95. 2000
    ..Throughout my research on all these subjects, I have been fortunate in obtaining unexpected observations and enjoying fruitful collaborations...
  2. ncbi request reprint Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis
    Takashi Muramatsu
    Department of Biochemistry, Nagoya University School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    J Biochem 132:359-71. 2002
    ..MK is also interesting from the viewpoints of the treatment of neurodegenerative diseases, increasing the efficiency of in vitro development, and the prevention of HIV infection...
  3. ncbi request reprint Development. Carbohydrate recognition in spermatogenesis
    Takashi Muramatsu
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Science 295:53-4. 2002
  4. ncbi request reprint Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion
    T Muramatsu
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Histol Histopathol 18:981-7. 2003
    ..Furthermore, the association of Bsg with integrins might be important in signaling through Bsg...
  5. ncbi request reprint [Function and medical significance of a growth factor, midkine]
    Takashi Muramastu
    Tanpakushitsu Kakusan Koso 47:1259-67. 2002
  6. ncbi request reprint alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor
    Hisako Muramatsu
    Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 117:5405-15. 2004
    ..alpha4beta1- and alpha6beta1-Integrins are expected to co-operate with other midkine receptors, possibly in a multimolecular complex that contains other midkine receptors...
  7. ncbi request reprint ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity
    Guo Yun Chen
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa, Nagoya 466 8550, Japan
    Gene 340:71-81. 2004
    ..Furthermore, co-transfection assays demonstrated that ZEC could activate a reporter luciferase gene driven by this DNA sequence...
  8. ncbi request reprint Demonstration of the pleiotrophin-binding oligosaccharide sequences isolated from chondroitin sulfate/dermatan sulfate hybrid chains of embryonic pig brains
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, 4 19 1, Motoyama kita machi, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 280:35318-28. 2005
    ....
  9. ncbi request reprint Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells
    Sen Chen
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 120:4009-15. 2007
    ..Collectively, these data demonstrate a crucial role of MK-LRP1 signaling in anchorage-independent cell growth...
  10. ncbi request reprint Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion
    Waichi Sato
    Department of Clinical Immunology of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 67:1330-9. 2005
    ..In the present investigation, we planned to evaluate the usefulness of antisense midkine for the therapy of ischemic renal failure...
  11. ncbi request reprint Midkine, a heparin-binding growth factor, is expressed in neural precursor cells and promotes their growth
    Peng Zou
    Department of Biochemistry, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 99:1470-9. 2006
    ..These results indicate that midkine is involved in the growth of neural precursor cells and suggest that the interaction with heparan sulfate proteoglycans is important in midkine action to these cells...
  12. ncbi request reprint Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors
    Hisako Muramatsu
    Department of Biochemistry, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Genes Cells 11:1405-17. 2006
    ..These abnormalities in combination resulted in female infertility. Therefore, midkine and pleiotrophin, together with their signaling receptors, play important roles in the female reproductive system...
  13. ncbi request reprint Effects of valsartan versus amlodipine in diabetic hypertensive patients with or without previous cardiovascular disease
    Kentaro Yamashita
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Cardiol 112:1750-6. 2013
    ..For stroke events, the ARB may have more protective effects than the CCB in diabetic hypertensive patients with previous CVD. ..
  14. pmc Abnormalities caused by carbohydrate alterations in Ibeta6-N-acetylglucosaminyltransferase-deficient mice
    Guo Yun Chen
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Mol Cell Biol 25:7828-38. 2005
    ..However, cataracts did not develop earlier in the deficient mice. Decreased levels of lysosomal proteins, LAMP-2 and synaptotagmin VII, were found in the kidney of the deficient mice and correlated with renal abnormalities...
  15. doi request reprint Comparison between valsartan and amlodipine regarding cardiovascular morbidity and mortality in hypertensive patients with glucose intolerance: NAGOYA HEART Study
    Takashi Muramatsu
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 8550, Japan
    Hypertension 59:580-6. 2012
    ..Admission because of heart failure was significantly less in the valsartan group...
  16. pmc Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1
    Kazuma Sakamoto
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    J Biol Chem 286:8405-13. 2011
    ..Our results suggest that the premature ligand-receptor interaction plays a role in protein production within the secretory pathway...
  17. pmc Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage
    Hanayo Kawai
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Pathol 165:1603-12. 2004
    ..The results indicate the crucial role of inflammation in cisplatin-induced renal damage, and provide a candidate molecular target for its prevention...
  18. pmc Growth factor midkine is involved in the pathogenesis of diabetic nephropathy
    Tomoki Kosugi
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Pathol 168:9-19. 2006
    ..Therefore, this study identifies midkine as a key molecule in diabetic nephropathy and suggests that midkine accelerates the intracellular signaling network evoked by hyperglycemia in nephropathy...
  19. doi request reprint Cardiovascular events increased at normal and high-normal blood pressure in young and middle-aged Japanese male smokers but not in nonsmokers
    Takahisa Kondo
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hypertens 31:263-70. 2013
    ..To clarify whether the impact of normal and high-normal BP (BP) per se on cardiovascular disease (CVD) and all-cause death differs depending on smoking status...
  20. ncbi request reprint Proteasomal degradation of the nuclear targeting growth factor midkine
    Noriyuki Suzuki
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 279:17785-91. 2004
    ..Together, these data highlight the desensitization of nuclear targeting by growth factors and indicate a critical role of the proteasome system in it...
  21. ncbi request reprint Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts
    Hiroshi Banno
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Vasc Surg 44:633-41. 2006
    ..In this study, we evaluated a strategy of using small interfering RNA (siRNA) targeting MK as a therapy for vein graft failure...
  22. ncbi request reprint The role of midkine and pleiotrophin in liver regeneration
    Keiko Ochiai
    Department of Biochemistry, Center for Neural Disease and Cancer, Nagyoa University Graduate School of Medicine, Nagoya 466 8550, Japan
    Liver Int 24:484-91. 2004
    ..We studied roles of two closely related heparin-binding growth factors, midkine (MK) and plieotrophin (PTN) in the processes of liver regeneration after partial hepatectomy...
  23. ncbi request reprint Reduction of alpha-galactosyl xenoantigen by expression of endo-beta-galactosidase C in pig endothelial cells
    Haruko Ogawa
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan
    Xenotransplantation 9:290-6. 2002
    ....
  24. ncbi request reprint Morpholino antisense oligomer targeting human midkine: its application for cancer therapy
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 114:490-7. 2005
    ..Serological examinations demonstrated no toxicity of MK morpholino antisense oligomers. Our study indicates that inhibition of MK expression by morpholino antisense oligomer is a promising novel and safe therapeutic strategy for cancers...
  25. ncbi request reprint In vivo gene transfer of endo-beta-galactosidase C removes alphaGal antigen on erythrocytes and endothelial cells of the organs
    Yusuke Miki
    Department of Clinical Immunology, Nagoya University Graduate School of Medicine, Tsurumaicho, Nagoya, Japan
    Xenotransplantation 11:444-51. 2004
    ..We have reported that administration of recombinant endo-beta-galactosidase C (EndoGalC) removes alphaGal on porcine erythrocytes and kidneys. The present study examined the effects of EndoGalC gene therapy on alphaGal suppression...
  26. ncbi request reprint Smoking and smoking cessation in relation to all-cause mortality and cardiovascular events in 25,464 healthy male Japanese workers
    Takahisa Kondo
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Circ J 75:2885-92. 2011
    ..Smoking is still a major health problem among males in Japan. The effects of smoking and quitting on mortality and cardiovascular disease (CVD) need updating...
  27. ncbi request reprint Doxorubicin-conjugated anti-midkine monoclonal antibody as a potential anti-tumor drug
    Kazuhiko Inoh
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Clin Oncol 36:207-11. 2006
    ..Midkine is a heparin-binding growth factor preferentially expressed in tumor cells. The present study was performed to utilize anti-midkine antibody for tumor therapy...
  28. ncbi request reprint Glycosaminoglycan structures required for strong binding to midkine, a heparin-binding growth factor
    Peng Zou
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Glycobiology 13:35-42. 2003
    ..Together with results of previous studies, we concluded that the multivalent trisulfated heparin-like unit is another structure involved in strong binding to MK...
  29. doi request reprint In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mol Cancer Ther 7:211-21. 2008
    ..Our data will provide the technical basis for in vivo electroporation, and this simple and efficient siRNA delivery method is applicable to in vivo comprehensive screening for a molecular target...
  30. ncbi request reprint The significance of measuring body fat percentage determined by bioelectrical impedance analysis for detecting subjects with cardiovascular disease risk factors
    Kentaro Yamashita
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Circ J 76:2435-42. 2012
    ..Body fat percentage (BF%) determined by bioelectrical impedance analysis is widely used at home and in medical check-ups. However, the clinical significance of measuring BF% has not been studied in detail...
  31. doi request reprint Embryonic stem cells deficient in I beta1,6-N-acetylglucosaminyltransferase exhibit reduced expression of embryoglycan and the loss of a Lewis X antigen, 4C9
    Hisako Muramatsu
    Department of Biochemistry, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya 468 8550, Japan
    Glycobiology 18:242-9. 2008
    ....
  32. ncbi request reprint Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer 107:864-73. 2006
    ..Midkine (MK) is a heparin-binding growth factor that promotes the growth, migration, and survival of various cells. Its overexpression has been observed in many human malignancies, making it an attractive therapeutic target...
  33. ncbi request reprint Mice doubly deficient in the midkine and pleiotrophin genes exhibit deficits in the expression of beta-tectorin gene and in auditory response
    Peng Zou
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Lab Invest 86:645-53. 2006
    ..The present finding illustrates the importance of growth factor expression in the cochlea for auditory function...
  34. ncbi request reprint Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis
    Kiyoko Maruyama
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Arthritis Rheum 50:1420-9. 2004
    ..The essential role of MK in migration of inflammatory cells has been shown using mice deficient in the MK gene (Mdk(-/-) mice). We undertook this study to investigate the role of MK in the pathogenesis of rheumatoid arthritis (RA)...
  35. ncbi request reprint N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing
    Kenji Uchimura
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 279:35001-8. 2004
    ..The importance of GlcNAc6ST-1 is particularly high-lighted by its involvement in lymphocyte homing to Peyer's patches where GlcNAc6ST-2 expression is undetectable...
  36. ncbi request reprint Carbohydrate antigens expressed on stem cells and early embryonic cells
    Takashi Muramatsu
    Department of Biochemistry and Division of Animal Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Glycoconj J 21:41-5. 2004
    ..On the other hand, O-linked oligosaccharides on CD34 and CD164 are probably involved in the regulation of cell adhesion and proliferation via intercellular recognition...
  37. ncbi request reprint Midkine as a molecular target: comparison of effects of chondroitin sulfate E and siRNA
    Hideki Yamamoto
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 351:915-9. 2006
    ..These results indicate the significance of midkine as a molecular target to treat or prevent rheumatoid arthritis and adhesion after surgery, and the utility of chondroitin sulfate E to inhibit midkine in vivo...
  38. ncbi request reprint Expression of glucose transporter 4 in the human pancreatic islet of Langerhans
    Honami Kobayashi
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 314:1121-5. 2004
    ..This study provides the first evidence that GLUT4 is present in human and rat pancreatic islets and may suggest its specific role in glucose homeostasis in conjunction with IRAP/P-LAP...
  39. ncbi request reprint Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese
    Takashi Muramatsu
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Prev Med 50:272-6. 2010
    ....
  40. ncbi request reprint Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 280:9180-91. 2005
    ..Thus, CS subpopulations with distinct structures in the mammalian brain play different roles in neuritogenesis through distinct molecular mechanisms, at least in part by regulating the functions of growth factors...
  41. doi request reprint Metabolic syndrome and all-cause mortality, cardiac events, and cardiovascular events: a follow-up study in 25,471 young- and middle-aged Japanese men
    Takahisa Kondo
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Cardiovasc Prev Rehabil 18:574-80. 2011
    ....
  42. ncbi request reprint Midkine expression in the course of nephrogenesis and its role in ischaemic reperfusion injury
    Waichi Sato
    Clinical Immunology of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nephrol Dial Transplant 17:52-4. 2002
    ....
  43. ncbi request reprint Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor beta-1
    Kensuke Sakai
    Department of Oral and Maxillofacial Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    J Dermatol Sci 31:99-109. 2003
    ..We identified one such factor produced by cultured oral epithelial cells as thrombospondin-1 (TSP-1). Recently, TSP-1 was reported to act as an activator of transforming growth factor-beta1 (TGF-beta1)...
  44. ncbi request reprint Antisense oligodeoxyribonucleotide as to the growth factor midkine suppresses neointima formation induced by balloon injury
    Kenji Hayashi
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Physiol Heart Circ Physiol 288:H2203-9. 2005
    ..The antisense ODN suppressed MK induction in vivo and consequently suppressed neointima formation to 60% of the control level. These results suggest that MK is a candidate molecular target for the therapy for vascular restenosis...
  45. ncbi request reprint Expression profile of mouse BWF1, a protein with a BEACH domain, WD40 domain and FYVE domain
    Guo Yun Chen
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cell Struct Funct 29:35-42. 2004
    ..Confocal microscopy studies of the epitope-tagged BWF1 protein showed that the protein was a cytoplasmic one...
  46. ncbi request reprint Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147
    Sen Chen
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 324:147-53. 2004
    ..Our results clearly separate the effects of the induced null mutation from those of flanking genes and the genetic background, and provide a useful means of investigating the biological functions of Bsg...
  47. doi request reprint Morphological observation of the stria vascularis in midkine and pleiotrophin knockout mice
    Michihiko Sone
    Department of Otolaryngology, Nagoya University Graduate School of Medicine, Japan
    Auris Nasus Larynx 38:41-5. 2011
    ..In the present study, we focused on the roles of midkine and pleiotrophin in the stria vascularis and investigated morphological changes using mice deficient in these genes...
  48. ncbi request reprint Midkine, a heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung carcinoma cells
    Ragaa H M Salama
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Lett 233:16-20. 2006
    ..Midkine strongly enhanced migration of Lewis lung carcinoma cells in vitro. Therefore, midkine is also a host factor enhancing tumor metastasis. Anti-midkine therapy for malignancy may act on midkine produced by both the tumor and host...
  49. ncbi request reprint Recognition of glycosaminoglycans by midkine
    Takashi Muramatsu
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Methods Enzymol 363:365-76. 2003
  50. ncbi request reprint Independent association of liver fat accumulation with insulin resistance
    Hiroshi Yatsuya
    Department of Public Health, Fujita Health University, Toyoake, Japan Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan Electronic address
    Obes Res Clin Pract 8:e350-5. 2014
    ....
  51. ncbi request reprint N-Acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury
    Haoqian Zhang
    Department of Biochemistry, Institute for Advanced Research, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Glycobiology 16:702-10. 2006
    ..These findings highlight the indispensable role of GlcNAc6ST-1 in brain KS biosynthesis and glial scar formation after brain injury...
  52. ncbi request reprint Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons
    Nahoko Sakaguchi
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neurosci Res 45:219-24. 2003
    ..The survival-promoting activity of MK was abolished by PP1, an inhibitor of src protein kinase, pertussis toxin, an inhibitor of G protein-linked signaling and sodium orthovanadate, an inhibitor of PTPs...
  53. ncbi request reprint Midkine expression is associated with postnatal development of the lungs
    Onrai Matsuura
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Cell Struct Funct 27:109-15. 2002
    ..Furthermore, a pronounced induction of midkine by retinoic acid was observed in neonatal lungs. The results indicate that midkine expression is associated with postnatal lung development, but not necessarily with hyperoxic cell damage...
  54. ncbi request reprint Midkine, a heparin-binding cytokine, plays key roles in intraperitoneal adhesions
    Kazuhiko Inoh
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 317:108-13. 2004
    ..Therefore, midkine was concluded to play important roles in the formation of intraperitoneal adhesions, at least partly by promoting the migration of macrophages and neutrophils to the omentum...
  55. ncbi request reprint A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Cancer Res 64:3365-70. 2004
    ..c. xenograft model. Atelocollagen provided a beneficial delivering means by which stabilization and efficient transfection of the siRNA injected into the tumors were achieved...
  56. ncbi request reprint Midkine, a heparin-binding growth factor, promotes growth and glycosaminoglycan synthesis of endothelial cells through its action on smooth muscle cells in an artificial blood vessel model
    Yukio Sumi
    Department of Oral and Maxillofacial Surgery, Nagoya Daini Red Cross Hospital, 2 9 Myoken cho, Showa Ku, Nagoya 466 8650, Japan
    J Cell Sci 115:2659-67. 2002
    ..Furthermore, interleukin-8 caused stratification of the endothelial cells in the blood vessel model. These results provided evidence that midkine is one of the factors involved in epithelial-mesenchymal interactions...
  57. ncbi request reprint Midkine and pleiotrophin in neural development and cancer
    Kenji Kadomatsu
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Lett 204:127-43. 2004
    ..Furthermore, antisense oligonucleotides for MK and ribozymes for PTN show anti-tumor activity. Therefore, MK and PTN are candidate molecular targets for therapy for human carcinomas...
  58. ncbi request reprint N-acetylglucosamine-6-O-sulfotransferase-1: production in the baculovirus system and its applications to the synthesis of a sulfated oligosaccharide and to the modification of oligosaccharides in fibrinogen
    Fathy M El-Fasakhany
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biochem 133:287-93. 2003
    ..The recombinant GlcNAc6ST-1 is a useful reagent for 6-sulfate exposed GlcNAc residues both in oligosaccharides and in glycoproteins...
  59. pmc Nuclear targeting by the growth factor midkine
    Yoshihisa Shibata
    Department of Biochemistry, Nagoya University School of Medicine, Showa Ku, Japan
    Mol Cell Biol 22:6788-96. 2002
    ..This study therefore reveals a novel role of LRP in intracellular signaling by its ligand and the importance of nucleolin in this process...
  60. ncbi request reprint Role of the carboxyl-terminal region in the activity of N-acetylglucosamine 6-o-sulfotransferase-1
    Lan Chen
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biochem 136:659-64. 2004
    ..Furthermore, the L477A mutant acted on a core 3 structure (GlcNAcbeta1-3GalNAc-pNP), while the wild-type enzyme does not. These results demonstrate a role for leucine residues in the C-terminal region in the enzymatic activity...
  61. ncbi request reprint Changes in activities of daily living, physical fitness, and depressive symptoms after six-month periodic well-rounded exercise programs for older adults living in nursing homes or special nursing facilities
    Pei OuYang
    Department of Public Health Health Information Dynamics, Field of Social Life Science, Nagoya University Graduate School of Medicine, Japan
    Nagoya J Med Sci 71:115-26. 2009
    ..2 sec to 25.3 sec (p = 0.01, paired t-test). These findings suggest that such a program could be effective in improving the ADL and physical fitness of the elderly...
  62. ncbi request reprint Syndecan-4 as a molecule involved in defense mechanisms
    Kazuhiro Ishiguro
    Department of Biochemistry and Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Glycoconj J 19:315-8. 2002
    ..Therefore, augmentation of TGF-beta function by induced syndecan-4 was suggested as a mechanism of the suppressive action of syndecan-4 against endotoxin shock...
  63. ncbi request reprint [Role of basigin, a glycoprotein belonging to the immunoglobulin superfamily, in the nervous system]
    Kenji Kadomatsu
    Tanpakushitsu Kakusan Koso 49:2417-24. 2004
  64. ncbi request reprint Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction
    Mitsuru Horiba
    Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Circulation 114:1713-20. 2006
    ..We investigated this hypothesis in mice with and without genetic MK deletion...
  65. doi request reprint Rationale and design of the NAGOYA HEART Study: comparison between valsartan and amlodipine regarding morbidity and mortality in patients with hypertension and glucose intolerance
    Kunihiro Matsushita
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    J Cardiol 56:111-7. 2010
    ..However, there is less evidence supporting this recommendation especially among East Asians, a population with a unique distribution of cardiovascular disease compared to the Western population...
  66. ncbi request reprint Uric acid and left ventricular hypertrophy in Japanese men
    Hirotsugu Mitsuhashi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Circ J 73:667-72. 2009
    ..In the present study, the relationship between serum UA levels and electrocardiographically-diagnosed LVH (ECG-LVH) was examined in Japanese men not taking medication for hypertension (HTN), which could confound the association...
  67. ncbi request reprint Mutational studies on endo-beta-N-acetylglucosaminidase D which hydrolyzes core portion of asparagine-linked complex type oligosaccharides
    Satoshi Yamamoto
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Showa Ku, Aichi, Japan
    Glycoconj J 22:35-42. 2005
    ..Mutation of E324 abolished Endo D activity. The specificity of Endo D for complex type oligosaccharides is probably defined by multiple domains in the Endo D structure...
  68. ncbi request reprint Increased midkine levels in sera from patients with Alzheimer's disease
    Ragaa H M Salama
    Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:611-6. 2005
    ..We found that serum MK levels in patients with AD were increased in comparison with those of normal controls...
  69. ncbi request reprint Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression
    Kenji Uchimura
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 277:3979-84. 2002
    ..Sumiya, J., Yonezawa, S., Nagata, K., and Yamashita, K. (2000) Glycobiology 10, 919-929)...
  70. ncbi request reprint 5'-,3'-inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine. Its design and application for cancer therapy
    Yoshifumi Takei
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 277:23800-6. 2002
    ..These findings indicated the usefulness of inverted thymidine-modified antisense oligodeoxynucleotides as a new reagent instead of phosphorothioate-modified oligodeoxynucleotides...
  71. ncbi request reprint Enzymatic removal of alphaGal antigen in pig kidneys by ex vivo and in vivo administration of endo-beta-galactosidase C
    DaGe Liu
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Xenotransplantation 9:228-36. 2002
    ..Alternatively, transgenic techniques of introducing the gene for EndoGalC into the donor organ might permanently prevent alphaGal expression...
  72. ncbi request reprint Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice
    Masamitsu Yanada
    First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Blood 99:2455-8. 2002
    ..The AT+/- mouse thus is a useful model for studying the effect of environmental or genetic risk factors on thrombogenesis...
  73. ncbi request reprint Tissue distribution of placental leucine aminopeptidase/oxytocinase during mouse pregnancy
    Honami Kobayashi
    Departments of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Histochem Cytochem 52:113-21. 2004
    ..Therefore, P-LAP may play a significant role in various physiological processes in non-pregnant, pregnant, and fetal mice...
  74. ncbi request reprint Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates
    Kenji Uchimura
    Department of Biochemistry, the Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya 466 8550, Japan
    J Biol Chem 277:1443-50. 2002
    ..This finding suggested that chondroitin 6-sulfate plays a role in the maintenance of naive T lymphocytes in the spleen of young mice...
  75. ncbi request reprint Distinct sulfation requirements of selectins disclosed using cells that support rolling mediated by all three selectins under shear flow. L-selectin prefers carbohydrate 6-sulfation totyrosine sulfation, whereas p-selectin does not
    Akiko Kanamori
    Program of Molecular Pathology, Aichi Cancer Center, Research Institute, Nagoya 464 8681, Japan
    J Biol Chem 277:32578-86. 2002
    ..E-selectin-mediated adhesion was sulfation-independent requiring only Fuc-T VII, and thus the three members of the selectin family have distinct requirements for ligand sulfation...
  76. ncbi request reprint Inhibition of osteopontin expression and function in oral cancer cell lines by antisense oligonucleotides
    Takashi Muramatsu
    Department of Pathology, Tokyo Dental College, 1 2 2, Masago, Mihama ku, Chiba 261 8502, Japan
    Cancer Lett 217:87-95. 2005
    ..Invasion ability in AS-group became significantly lower (P<0.01). These results suggest that BSC-OF cell is useful for over-expression of OPN, and that OPN contributes to morphology, growth and invasion...
  77. ncbi request reprint A promoter region of midkine gene can activate transcription of an exogenous suicide gene in human pancreatic cancer
    Yu Yoshida
    Division of Pathology, Chiba Cancer Center Research Institute, Japan
    Anticancer Res 22:117-20. 2002
    ..The present study suggests that preferential cytotoxic effects for pancreatic tumors can be achieved by using the MK promoter...
  78. ncbi request reprint Traumatic injury-induced midkine expression in the adult rat spinal cord during the early stage
    Harutoshi Sakakima
    School of Medical Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    J Neurotrauma 21:471-7. 2004
    ..These findings suggest that MK was produced in astrocytes approximating the damaged region and may represent a reparative neurotrophic factor during the early phase of traumatic injury of the spinal cord...
  79. ncbi request reprint Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor
    Yasuo Adachi
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Pediatr Surg 37:588-92. 2002
    ..We present herein the efficacy of in vivo tumor regression as well as prevention of lethal hepatic toxicity by using the MK promoter in an Ad vector-based HSV-tk/GCV treatment approach...
  80. ncbi request reprint Inactivation of the Basigin gene impairs normal retinal development and maturation
    Judith D Ochrietor
    The Whitney Laboratory of the University of Florida, 9505 Ocean Shore Boulevard, St, Augustine, FL 32080, USA
    Vision Res 42:447-53. 2002
    ..Although the architecture of the 5A11/Basigin null mouse retina appears normal, the ERG amplitudes are severely depressed at eye opening, indicating failure in retinal maturation...
  81. pmc Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population
    Jinyan Wang
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 105:3915-20. 2008
    ..These observations indicate that MK serves as a critical suppressor of Treg cell expansion, and inhibition of MK using RNA aptamers may provide an effective therapeutic strategy against autoimmune diseases, including multiple sclerosis...
  82. ncbi request reprint Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancer
    Hideaki Shimada
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8677, Japan
    Oncol Rep 10:411-4. 2003
    ..This S-MK positivity rate for detecting SESCC was significantly higher than for other tumor markers. Thus, S-MK may be useful as a tumor marker to detect SESCC...
  83. ncbi request reprint Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse
    Nancy J Philp
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Invest Ophthalmol Vis Sci 44:1305-11. 2003
    ..In the present study, the hypothesis that reduced amplitudes in the electroretinograms in the 5A11/basigin null mouse (Bsg(-/-)) may be linked to altered expression of MCTs was studied...
  84. ncbi request reprint Expression of basigin, a member of the immunoglobulin superfamily, in the mouse cochlea
    Hirokazu Kawano
    Department of Otorhinolaryngology, Miyazaki Medical College, Kihara, Miyazaki, Japan
    ORL J Otorhinolaryngol Relat Spec 65:327-31. 2003
    ..These findings suggest that Bsg may play an important role in the maintenance of homeostasis, not only of the neural environment in the auditory nerve but also of cochlear fluid...
  85. ncbi request reprint A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules
    Kenji Uchimura
    Department of Anatomy, Program in Immunology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Nat Immunol 6:1105-13. 2005
    ..Our results establish an essential function for the sulfotransferases in L-selectin ligand synthesis and may have relevance for therapy of inflammatory diseases...
  86. ncbi request reprint Connexin 43 transfection in basaloid squamous cell carcinoma cells
    Kaori Shima
    Department of Pathology, Tokyo Dental College, Chiba 261 8502, Japan
    Oncol Rep 16:285-8. 2006
    ..These results suggest that Cx43 plays a role as a tumor suppressor in the cytoplasm of Cx43-transfected BSC-OF cells. However, no definite correlation was found between Cx43 and cell migration and invasion...
  87. ncbi request reprint Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily
    Judith D Ochrietor
    Whitney Laboratory of the University of Florida, St Augustine, Florida 32080, USA
    Invest Ophthalmol Vis Sci 44:4086-96. 2003
    ..Previous reports indicate the presence of multiple 5A11/Basigin polypeptides within the retina. Therefore, in an effort to determine the function of 5A11/Basigin, the molecular diversity of its expression was evaluated...
  88. ncbi request reprint Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells
    Keiko Ichihara-Tanaka
    Department of Health Science, Faculty of Psychological and Physical Sciences, Aichi Gakuin University, 12 Araike, Iwasaki cho, Nisshin, Aichi 470 0195, Japan
    J Biol Chem 281:30857-64. 2006
    ..Based on these results, we conclude that neuroglycan C is a novel component of midkine receptors involved in process elongation...
  89. ncbi request reprint Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells
    Ling Yu
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
    Oncol Rep 10:1301-5. 2003
    ..The transcriptional activity of the MK promoter could be regulated by cell growth and in part P53-dependent pathways...
  90. ncbi request reprint N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules
    Hiroto Kawashima
    Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    Nat Immunol 6:1096-104. 2005
    ..These results demonstrate the essential function of GlcNAc6ST-1 and GlcNAc6ST-2 in L-selectin ligand biosynthesis in high endothelial venules and their importance in immune surveillance...
  91. ncbi request reprint Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8677, Japan
    Cancer Sci 94:628-32. 2003
    ..Multivariate analysis indicated that S-MK was an independent prognostic factor. S-MK may be a useful tumor marker for esophageal SCC. Increased preoperative S-MK in patients with esophageal SCC is associated with poor survival...
  92. ncbi request reprint Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter
    Ling Yu
    Division of Pathology, Chiba Cancer Center, Chiba, Japan
    Oncology 66:143-9. 2004
    ..These data showed that the MK promoter activated a therapeutic gene in a wider range of human breast cancer than the c-erbB-2 promoter and suggest that MK promoter-mediated gene therapy is potentially more favorable in clinical settings...
  93. ncbi request reprint Midkine protects hepatocellular carcinoma cells against TRAIL-mediated apoptosis through down-regulation of caspase-3 activity
    Tomoko Ohuchida
    Department of Surgery I, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer 100:2430-6. 2004
    ..However, the biologic mechanism of MK in hepatocellular carcinoma has not been clarified to date. The objective of the current study was to investigate the antiapoptotic role of MK in a human hepatoma cell line...
  94. ncbi request reprint Production and characterization of transgenic mice systemically expressing endo-beta-galactosidase C
    Satoshi Watanabe
    Animal Genome Research Unit, Division of Animal Science, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki 305 0901, Japan
    Glycobiology 18:9-19. 2008
    ..The present findings also provide some basis for evaluating possible application of the transgenic approach for xenotranplantation...
  95. ncbi request reprint Increased basigin in bleomycin-induced lung injury
    Tomoko Betsuyaku
    Department of Medicine and Cell Biology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri, USA
    Am J Respir Cell Mol Biol 28:600-6. 2003
    ..Accordingly, basigin may play a role in diffuse alveolar injury...
  96. ncbi request reprint Utilization of the promoter region of the midkine gene as a tool to drive therapeutic genes in a tumor specific manner
    Shigeru Sakiyama
    Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Adv Enzyme Regul 43:57-66. 2003