Y Murakumo

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc Rad9 modulates the P21WAF1 pathway by direct association with p53
    Kazuhiro Ishikawa
    Department of Otolaryngology Head and Neck Surgery, Jichi Medical University School of Medicine, Tochigi, Japan
    BMC Mol Biol 8:37. 2007
  2. ncbi request reprint Analyses of ultraviolet-induced focus formation of hREV1 protein
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Genes Cells 11:193-205. 2006
  3. ncbi request reprint RET and neuroendocrine tumors
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Pituitary 9:179-92. 2006
  4. ncbi request reprint Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7
    Y Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 276:35644-51. 2001
  5. ncbi request reprint The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mutat Res 510:37-44. 2002
  6. ncbi request reprint Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats
    Y Murakumo
    Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466, Japan
    Mamm Genome 7:505-8. 1996
  7. pmc Characterization of gene expression induced by RET with MEN2A or MEN2B mutation
    Tsuyoshi Watanabe
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Pathol 161:249-56. 2002
  8. ncbi request reprint Expression of glial cell line-derived neurotrophic factor correlates with perineural invasion of bile duct carcinoma
    Naoko Iwahashi
    Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan
    Cancer 94:167-74. 2002
  9. doi request reprint An actin-binding protein Girdin regulates the motility of breast cancer cells
    Ping Jiang
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 68:1310-8. 2008
  10. ncbi request reprint Akt/PKB regulates actin organization and cell motility via Girdin/APE
    Atsushi Enomoto
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Aichi, Japan
    Dev Cell 9:389-402. 2005

Collaborators

Detail Information

Publications42

  1. pmc Rad9 modulates the P21WAF1 pathway by direct association with p53
    Kazuhiro Ishikawa
    Department of Otolaryngology Head and Neck Surgery, Jichi Medical University School of Medicine, Tochigi, Japan
    BMC Mol Biol 8:37. 2007
    ..This study examined the exact mechanism of the hRad9 function, especially through the phosphorylation of the C-terminus, in the transcription regulation of P21WAF1...
  2. ncbi request reprint Analyses of ultraviolet-induced focus formation of hREV1 protein
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Genes Cells 11:193-205. 2006
    ..Furthermore, it was found that the hREV1 focus formation after UV irradiation required a region near the C-terminal (826-1178)...
  3. ncbi request reprint RET and neuroendocrine tumors
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Pituitary 9:179-92. 2006
    ..In this review, we summarize progress in the study of RET from bench to bedside, focusing on pathophysiology of neuroendocrine tumors...
  4. ncbi request reprint Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7
    Y Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 276:35644-51. 2001
    ..These findings suggest the possibility that hREV7 might play an important role in regulating the enzymatic activities of hREV1 and hREV3 for mutagenesis in response to DNA damage...
  5. ncbi request reprint The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mutat Res 510:37-44. 2002
    ..These findings give us a new point of view for further investigation about REV proteins. Recent studies of REV proteins are summarized and several points are discussed...
  6. ncbi request reprint Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats
    Y Murakumo
    Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466, Japan
    Mamm Genome 7:505-8. 1996
    ..Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13...
  7. pmc Characterization of gene expression induced by RET with MEN2A or MEN2B mutation
    Tsuyoshi Watanabe
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Pathol 161:249-56. 2002
    ....
  8. ncbi request reprint Expression of glial cell line-derived neurotrophic factor correlates with perineural invasion of bile duct carcinoma
    Naoko Iwahashi
    Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan
    Cancer 94:167-74. 2002
    ....
  9. doi request reprint An actin-binding protein Girdin regulates the motility of breast cancer cells
    Ping Jiang
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 68:1310-8. 2008
    ..These findings highlight the important role of Girdin in tumor progression in which the Akt signaling pathway is aberrantly activated...
  10. ncbi request reprint Akt/PKB regulates actin organization and cell motility via Girdin/APE
    Atsushi Enomoto
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Aichi, Japan
    Dev Cell 9:389-402. 2005
    ..These findings suggest that Girdin is essential for the integrity of the actin cytoskeleton and cell migration and provide a direct link between Akt and cell motility...
  11. doi request reprint Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus
    Atsushi Enomoto
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuron 63:774-87. 2009
    ..These findings identify girdin as an intrinsic factor in postnatal development of the DG and provide insights into the critical role of the DISC1/girdin interaction in postnatal neurogenesis in the DG...
  12. ncbi request reprint Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis
    Naoyuki Fukuda
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 278:50386-92. 2003
    ....
  13. ncbi request reprint RET and neuroendocrine tumors
    Masatoshi Ichihara
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Lett 204:197-211. 2004
    ..In this review, we describe the current knowledge about the molecular mechanism of RET activation in human neuroendocrine tumors as well as the physiological roles and signal transduction of RET tyrosine kinase...
  14. doi request reprint Processing of CD109 by furin and its role in the regulation of TGF-beta signaling
    S Hagiwara
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncogene 29:2181-91. 2010
    ....
  15. ncbi request reprint Genetic mapping of genes regulating the thymus size in back-cross rats between the laboratory BUF/Mna strain and the MITE strain derived from the wild rat, Rattus norvegicus
    N Sharma
    Department of Pathology, Nagoya University School of Medicine, Japan
    Pathol Int 47:436-41. 1997
    ..By analyses of MAPMAKER/EXP and MAPMAKER/QTL, Ten-1 was mapped at 4.6 cM proximal from IGF2 locus on chromosome 1 and Tsu-1 at 4.0 cM proximal from CAT locus on chromosome 3, respectively...
  16. ncbi request reprint [Mechanism of translesion DNA synthesis by DNA polymerase zeta]
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550
    Seikagaku 74:208-12. 2002
  17. doi request reprint Expression of Ret finger protein correlates with outcomes in endometrial cancer
    Hirohisa Tsukamoto
    Departments of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 100:1895-901. 2009
    ..Positive RFP expression is a predictive marker for an unfavorable clinical outcome in patients with endometrial cancer...
  18. doi request reprint Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice
    T Hasegawa
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncogene 27:5684-95. 2008
    ..These findings suggest that the increased expression of MKP-2 may play a crucial role in oncogenic signaling downstream of mutant RET, leading to deregulation of cell cycle...
  19. ncbi request reprint Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system
    Y Shimoyama
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuroscience 121:899-906. 2003
    ..SEP1 was co-immunoprecipitated with alpha- and beta-tubulins from the lysate of mouse brain. These results thus suggested that SEP1 is a GDNF-inducible and microtubule-associated protein that may play a role in the nervous system...
  20. ncbi request reprint Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region
    Yoshinori Kodama
    Department of Pathology, Nagoya University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 320:108-15. 2004
    ..However, neuritogenesis of TGW cells was mostly dependent on Src family kinase activity and not ERK activity, indicating that the increased expression of CRMP-2 alone was not sufficient for neuritogenesis...
  21. ncbi request reprint Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties
    Yi Jin
    Department of Pathology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Sci 95:815-21. 2004
    ..These findings suggest that CKAP2 is a new MAP with microtubule-stabilizing properties and may represent a new molecular target for cancer chemotherapy...
  22. ncbi request reprint CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells
    Masaki Hasegawa
    Department of Pathology, Nagoya University Graduate School of Medicine, and Department of Pathology, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan
    Pathol Int 57:245-50. 2007
    ..CD109 expression was negative in examined breast ductal carcinomas and prostate adenocarcinomas. These findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas...
  23. ncbi request reprint Fine mapping of thymus enlargement gene 1 (Ten1) in BUF/Mna rats
    C Ye
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan
    Pathol Int 50:185-90. 2000
    ..5 and the distal end of mouse Chr 7 or with human 11q13 and the proximal end of mouse Chr 19. Genes existing in these regions are discussed as candidate genes for Ten1...
  24. ncbi request reprint Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase
    Mayumi Uchida
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 119:3067-77. 2006
    ..Together, our results suggest that Dok-4, through activation of the Rap1-ERK1/2 pathway, regulates GDNF-mediated neurite outgrowth during neuronal development...
  25. ncbi request reprint High-level expression of CD109 is frequently detected in lung squamous cell carcinomas
    Tomoko Sato
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Int 57:719-24. 2007
    ..Although the detailed function of CD109 protein is unclear, these results suggest that CD109 expression may play a role in the development of lung squamous cell carcinoma...
  26. ncbi request reprint RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease
    Naoya Asai
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Int 56:164-72. 2006
    ..The focus of the present review is on recent progress in the study of RET signaling dysfunction in human diseases...
  27. ncbi request reprint CD109 expression in squamous cell carcinoma of the uterine cervix
    Jing Min Zhang
    Department of Pathology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Int 55:165-9. 2005
    ..These findings suggest that CD109 may become a molecular target for the development of new therapeutics for squamous cell carcinoma of various tissue origins...
  28. ncbi request reprint Role for O-glycosylation of RFP in the interaction with enhancer of polycomb
    Gaye Tezel
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 290:409-14. 2002
    ..In addition, the luciferase reporter gene assay showed that expression of the EPcA region strongly impairs the transcriptional repressive activity of RFP...
  29. ncbi request reprint Cys611Ser mutation in RET proto-oncogene in a kindred with medullary thyroid carcinoma and Hirschsprung's disease
    Mikiko Nishikawa
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Eur J Hum Genet 11:364-8. 2003
    ..This clinical case substantiates our suggestion for the mechanism of the development of both the diseases...
  30. ncbi request reprint The RET proto-oncogene: a molecular therapeutic target in thyroid cancer
    Yoshinori Kodama
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku Nagoya, 466 8550, Japan
    Cancer Sci 96:143-8. 2005
    ..RET and some signaling molecules that function downstream of RET could be potential targets for the development of selective cancer therapeutics...
  31. pmc A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia
    Mayumi Jijiwa
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mol Cell Biol 24:8026-36. 2004
    ..Thus, these findings demonstrated that the signal via tyrosine 1062 plays an important role in histogenesis of the enteric nervous system and nephrogenesis...
  32. pmc GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region
    Takatoshi Morinaga
    Department of Pathology, Nagoya University Graduate School of Medicine 65 Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Nucleic Acids Res 33:4191-201. 2005
    ..These findings thus suggest that GZF1 may regulate the spatial and temporal expression of the HOXA10 gene which plays a role in morphogenesis...
  33. doi request reprint Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress
    Takuya Kato
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Cancer Res 69:3597-604. 2009
    ..These findings reveal the diverse cancer-promoting activities of HDAC1 and identify RFP as a key regulator that provides cancer cells with resistance to anticancer drugs...
  34. ncbi request reprint Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation
    Atsushi Dambara
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Exp Cell Res 313:3755-66. 2007
    ..Finally, we found that knockdown of GZF1 and nucleolin expression markedly impaired cell proliferation. These findings suggest that the physiological functions of GZF1 may be regulated by the protein's association with nucleolin...
  35. doi request reprint CD109 expression in basal-like breast carcinoma
    Masaki Hasegawa
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Int 58:288-94. 2008
    ..05). These findings indicate that CD109 is a useful diagnostic marker for BLC and that CD109 expression may affect biological properties of cancer cells...
  36. ncbi request reprint Expression of CD109 in human cancer
    Mizuo Hashimoto
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Oncogene 23:3716-20. 2004
    ..Thus, these results suggested that CD109 might be a useful molecular target for the development of new therapeutics for malignant tumors, such as squamous cell carcinoma...
  37. ncbi request reprint Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase
    Maki Ishida
    Department of Pathology, and Department of Mrfovs Technology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 98:815-21. 2007
    ..Taken together, our results suggest that SPRY2 regulates GDNF-dependent proliferation and differentiation of TGW neuroblastoma cells mediated by RET tyrosine kinase...
  38. doi request reprint Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells
    Ai Kurotsuchi
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:1147-55. 2010
    ..These findings indicate that DOK-6 is involved in RET signaling with less influence when compared with DOK-1, DOK-4, and SHC...
  39. ncbi request reprint Interaction of hREV1 with three human Y-family DNA polymerases
    Eiji Ohashi
    Institute for Virus Research, Kyoto University, 53 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Genes Cells 9:523-31. 2004
    ..Thus, our results suggest that hREV1 plays a pivotal role in the multi-enzyme, multi-step process of translesion DNA synthesis...
  40. ncbi request reprint Components of DNA damage checkpoint pathway regulate UV exposure-dependent alterations of gene expression of FHIT and WWOX at chromosome fragile sites
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Mol Cancer Res 3:130-8. 2005
    ....
  41. ncbi request reprint A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1
    Chikage Suzuki
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8850, Japan
    Biochem Biophys Res Commun 366:226-32. 2008
    ..Furthermore, siRNA-mediated silencing of BMZF3 inhibited cell proliferation. These findings suggest that BMZF3 is a transcriptional repressor induced by GDNF that plays a role in cell proliferation...
  42. ncbi request reprint Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation
    Kumi Kawai
    Department of Molecular Pathology, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550
    Cancer Sci 94:992-7. 2003
    ..These results may reflect the profiles of the transcriptional changes associated with dedifferentiation or progression of mammary carcinomas developed in genetically engineered mice...