T Mizutani

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint PM frequencies of major CYPs in Asians and Caucasians
    Takaharu Mizutani
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 35:99-106. 2003
  2. ncbi request reprint Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 37:235-52. 2005
  3. ncbi request reprint SBP, SECIS binding protein, binds to the RNA fragment upstream of the Sec UGA codon in glutathione peroxidase mRNA
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Mol Biol Rep 27:99-105. 2000
  4. ncbi request reprint Eukaryotic selenocysteine tRNA has the 9/4 secondary structure
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    FEBS Lett 466:359-62. 2000
  5. ncbi request reprint Selenophosphate as a substrate for mammalian selenocysteine synthase, its stability and toxicity
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    Biofactors 9:27-36. 1999
  6. ncbi request reprint New horizon of MDR1 (P-glycoprotein) study
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 37:489-510. 2005
  7. ncbi request reprint Genuine functions of P-glycoprotein (ABCB1)
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603 Japan
    Curr Drug Metab 9:167-74. 2008
  8. ncbi request reprint A G.U base pair in the eukaryotic selenocysteine tRNA is important for interaction with SePF, the putative selenocysteine-specific elongation factor
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    FEBS Lett 429:189-93. 1998
  9. ncbi request reprint pGp as the main product of bovine tRNA kinase
    Takaharu Mizutani
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467 8603 Japan
    Mol Biol Rep 29:293-300. 2002
  10. pmc Some properties of murine selenocysteine synthase
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    Biochem J 284:827-34. 1992

Collaborators

  • Ken ichi Saeki
  • K Yamada
  • Yutaka Nakamura
  • Yuko Ito
  • H Kurata
  • K Yamamoto
  • Kenji Furumiya
  • Masatoshi Masuda
  • Masakazu Shinoda
  • Hiroshi Togawa
  • Taka aki Kato
  • Hitomi Mori
  • Yuta Tanaka
  • Nayumi Kuno
  • Takashi Osaka
  • Yoshie Hirano
  • Masanobu Kanou
  • C Goto
  • Shigeko Shinkai
  • Kazutaka Tanabe
  • Emi Nakai
  • K Tajima
  • Kazuo Kanaya
  • Yasuko Murakami
  • Senya Matsufuji
  • Takuya Kuno
  • Tamiko Matsufuji
  • Koichi H Kato
  • Asuka Hattori
  • Asa Beika
  • Yoshinori Kohno
  • Saburo Matsui
  • Kazuhiko Takahashi
  • Tomonari Matsuda
  • T Osaka
  • M Hashizaki
  • S Narimatsu

Detail Information

Publications27

  1. ncbi request reprint PM frequencies of major CYPs in Asians and Caucasians
    Takaharu Mizutani
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 35:99-106. 2003
    ..In both populations, the PM frequencies of the CYP3A4 of major drug-metabolizing CYP and CYP2C9 were low...
  2. ncbi request reprint Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 37:235-52. 2005
    ..Autoantibodies against CYP11A1, CYP17, and/or CYP21 involved in the synthesis of steroid hormones are also detected in patients with adrenal failure, gonadal failure, and/or Addison disease...
  3. ncbi request reprint SBP, SECIS binding protein, binds to the RNA fragment upstream of the Sec UGA codon in glutathione peroxidase mRNA
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Mol Biol Rep 27:99-105. 2000
    ..This model explains that the stem-loop structure covering the UGA codon is recognized by SBP and how the UGA Sec codon escapes from attack by eRF of the peptide releasing factor...
  4. ncbi request reprint Eukaryotic selenocysteine tRNA has the 9/4 secondary structure
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    FEBS Lett 466:359-62. 2000
    ..Finally, we conclude that all tRNA(Sec) possess the 13 bp domain II made by the stacking of the colinear AA and T-stems, whether they present the 9/4 structure in Eukarya and Archaea or the 8/5 structure in bacteria...
  5. ncbi request reprint Selenophosphate as a substrate for mammalian selenocysteine synthase, its stability and toxicity
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    Biofactors 9:27-36. 1999
    ..Thus, SeP was proved to be stable at low temperature, under acidic and anaerobic conditions, but labile under neutral and alkaline conditions. The LD50 of SeP administered i.p. to mice was 37.5 mg/kg body weight...
  6. ncbi request reprint New horizon of MDR1 (P-glycoprotein) study
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 37:489-510. 2005
    ..There is an ambiguity about the function of MDR1 as GlcCer translocase...
  7. ncbi request reprint Genuine functions of P-glycoprotein (ABCB1)
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603 Japan
    Curr Drug Metab 9:167-74. 2008
    ..We also present information about P-gp polymorphism and new structural concepts, "gate" and "twist", of the P-gp structure...
  8. ncbi request reprint A G.U base pair in the eukaryotic selenocysteine tRNA is important for interaction with SePF, the putative selenocysteine-specific elongation factor
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    FEBS Lett 429:189-93. 1998
    ....
  9. ncbi request reprint pGp as the main product of bovine tRNA kinase
    Takaharu Mizutani
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467 8603 Japan
    Mol Biol Rep 29:293-300. 2002
    ..These results indicated that tRNA kinase phosphorylates not only Ser-tRNA to phosphoser-tRNA but also Gp of the 5'-termini of tRNA to pGp. This study gives a new role to mammalian tRNA kinase...
  10. pmc Some properties of murine selenocysteine synthase
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    Biochem J 284:827-34. 1992
    ..This mammalian mechanism used to synthesize Scy is similar to that seen in Escherichia coli...
  11. ncbi request reprint The dual identities of mammalian tRNA(Sec) for SerRS and selenocysteine synthase
    T Mizutani
    Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    Mol Biol Rep 25:211-6. 1998
    ..This shows that SerRS measures the distance between the discrimination base and long extra arm for recognition of tRNASer...
  12. ncbi request reprint A model for Sec incorporation with the regions upstream of the UGA Sec codon to play a key role
    C Goto
    Faculty of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8603, Japan
    Biofactors 14:25-35. 2001
    ..This model explains that the stem-loop structure covering the UGA codon is recognized by SBP and how the UGA Sec codon escapes from attack by eRF...
  13. ncbi request reprint Activation of the human Ah receptor by aza-polycyclic aromatic hydrocarbons and their halogenated derivatives
    Ken ichi Saeki
    Faculty of Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Nagoya, Japan
    Biol Pharm Bull 26:448-52. 2003
    ..Greatest enhancement of ligand activity was observed in 2-brominated BfQ (2-Br-BfQ), and its ligand activity was higher than that of BaP. These results suggest that even monohalogenation markedly enhances AhR ligand activity in aza-PAHs...
  14. ncbi request reprint High levels of autoantibodies against drug-metabolizing enzymes in SLA/LP-positive AIH-1 sera
    Masakazu Shinoda
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Autoimmunity 37:473-80. 2004
    ..We found that the pattern of elevation in the Patient 3 serum was not parallel with that in Patient 4. Thus, we found high levels of autoantibodies against drug-metabolizing enzymes in AIH-1 patients...
  15. doi request reprint Inhibition of human CYP3A4, UGT1A6, and P-glycoprotein with halogenated xanthene food dyes and prevention by superoxide dismutase
    Kenji Furumiya
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Toxicol Environ Health A 71:1307-13. 2008
    ..It is possible that red cosmetics containing phloxine, erythrosine, or rose bengal react with proteins in skin and may lead to skin damage...
  16. ncbi request reprint Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs
    Katsuya Yamada
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Mutat Res 586:87-95. 2005
    ....
  17. ncbi request reprint The N-terminal of human UGT1A6 is on the outside, as evidenced by ELISA with autoantibody in autoimmune hepatitis sera
    Hitomi Mori
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 1:261-6. 2007
    ..In conclusion, sera from AIH-1 patients reacted with the amino acids in the sequence 33-37 (PQDGS) of the N-terminal of UGT1A6...
  18. ncbi request reprint A new method to measure P-gp (ABCB1) activity
    Masatoshi Masuda
    Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedo ri, Mizuho, Nagoya 467 8603, Japan
    Drug Metab Lett 1:306-10. 2007
    ..This method is also applicable to other ATP-binding cassette (ABC) transporters in phosphate buffer...
  19. ncbi request reprint Purification and some properties of two enzymes from rat liver cytosol that catalyze carbonyl reduction of 6-tert-butyl-2, 3-epoxy-5-cyclohexene-1,4-dione, a metabolite of 3-tert-butyl-4-hydroxyanisole
    K Tajima
    Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, 920 1181, Japan
    Arch Biochem Biophys 361:207-14. 1999
    ..Dicoumarol inhibited significantly TBE-R1 activity but not TBE-R2 activity. In the conversion of TBE to TBEH, TBE-R1 preferentially reduced TBE to (4R)-TBEH, whereas TBE-R2 preferred the reduction of TBE to (4S)-TBEH...
  20. ncbi request reprint Induction of human UGT1A1 by bilirubin through AhR dependent pathway
    Hiroshi Togawa
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 2:231-7. 2008
    ..This is the first report showing direct induction of UGT1A1 by a bilirubin through AhR pathway...
  21. ncbi request reprint Active bovine selenophosphate synthetase 2, not having selenocysteine
    Kenji Furumiya
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467 8603, Japan
    Mol Biol Rep 35:541-9. 2008
    ..Thus, bovine active SPS2 of molecular mass 33 kDa does not contain Sec...
  22. ncbi request reprint The protozoa dinoflagellate Oxyrrhis marina contains selenoproteins and the relevant translation apparatus
    Takashi Osaka
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biochem Biophys Res Commun 300:236-40. 2003
    ..Altogether, our data showed that O. marina contains selenoproteins and suggests that the corresponding translation machinery is related to that found in animals...
  23. ncbi request reprint Influence of synthetic and natural food dyes on activities of CYP2A6, UGT1A6, and UGT2B7
    Nayumi Kuno
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Toxicol Environ Health A 68:1431-44. 2005
    ..In the natural additive dyes just listed, only monascus inhibited UGT1A6 and UGT2B7...
  24. ncbi request reprint Study of inhibition of CYP2A6 by some drugs derived from quinoline
    Yoshie Hirano
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya 467 8603, Japan
    J Pharm Pharmacol 55:1667-72. 2003
    ..These results also show that CYP2A6 discriminates the structure difference between the diastereoisomers quinidine and quinine...
  25. ncbi request reprint Activation of the aryl hydrocarbon receptor by methyl yellow and related congeners: structure-activity relationships in halogenated derivatives
    Taka aki Kato
    Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 25:466-71. 2002
    ..These results suggest that the amide bond is equivalent to the -N=N- or -CH=CH- double bond for recognition as the ligand by AhR in 1,2-diphenyl-1,2-ene derivatives...
  26. ncbi request reprint Study of in vitro glucuronidation of hydroxyquinolines with bovine liver microsomes
    Masanobu Kanou
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Fundam Clin Pharmacol 16:513-7. 2002
    ..Fluoroquinoline (FQ) derivatives, such as 3FQ, 7.8diFQ and 6,7,8triFQ, did not show any substrate activities. These results suggest that there are therapeutic problems in administration of some quinoline drugs to patients with jaundice...
  27. ncbi request reprint Study of oxidized lipids as endogenous substrates of P-gp (ABCB1)
    Masatoshi Masuda
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 2:238-44. 2008
    ..This finding should be a milestone to search a new physiological P-gp function...