M Mizokami

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint Tracing the evolution of hepatitis C virus in the United States, Japan, and Egypt by using the molecular clock
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Gastroenterol Hepatol 3:S82-5. 2005
  2. ncbi request reprint Hepatitis B virus genotype assignment using restriction fragment length polymorphism patterns
    M Mizokami
    Department of Blood Transfusion, Nagoya City University Medical School, Nagoya, Japan
    FEBS Lett 450:66-71. 1999
  3. ncbi request reprint Spread times of hepatitis C virus estimated by the molecular clock differ among Japan, the United States and Egypt in reflection of their distinct socioeconomic backgrounds
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Intervirology 49:28-36. 2006
  4. ncbi request reprint Molecular evolutionary analysis predicts the incidence of hepatocellular carcinoma in the United States and Japan
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Cancer Chemother Pharmacol 54:S83-6. 2004
  5. ncbi request reprint Mutation patterns for two flaviviruses: hepatitis C virus and GB virus C/hepatitis G virus
    M Mizokami
    Second Department of Medicine, Nagoya City University Medical School, Nagoya, Japan
    FEBS Lett 450:294-8. 1999
  6. ncbi request reprint Lack of integrated TT virus (TTV) genomes in cellular DNA in infected human hematopoietic cells
    Y Tanaka
    Second Department of Medicine, Nagoya City University Medical School, Mizuho, Nagoya, Japan
    Leuk Lymphoma 38:411-7. 2000
  7. ncbi request reprint Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China
    X Ding
    Second Department of Medicine, Nagoya City University School, Nagoya, Japan
    Intervirology 44:43-7. 2001
  8. ncbi request reprint Determination of hepatitis B virus genotype G by polymerase chain reaction with hemi-nested primers
    H Kato
    Second Department of Medicine, Nagoya City University Medical School, Nagoya 467-8601, Japan
    J Virol Methods 98:153-9. 2001
  9. ncbi request reprint A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: complete genome sequence and phylogenetic relatedness
    F Sugauchi
    Second Department of Internal Medicine and Laboratory Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, 467-8601 Nagoya, Japan
    J Gen Virol 82:883-92. 2001
  10. ncbi request reprint Identification of a novel 23kDa protein encoded by putative open reading frame 2 of TT virus (TTV) genotype 1 different from the other genotypes
    Y Tanaka
    Second Department of Medicine, Nagoya City University Medical School, Japan
    Arch Virol 145:1385-98. 2000

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Tracing the evolution of hepatitis C virus in the United States, Japan, and Egypt by using the molecular clock
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Gastroenterol Hepatol 3:S82-5. 2005
    ....
  2. ncbi request reprint Hepatitis B virus genotype assignment using restriction fragment length polymorphism patterns
    M Mizokami
    Department of Blood Transfusion, Nagoya City University Medical School, Nagoya, Japan
    FEBS Lett 450:66-71. 1999
    ..This simple and accurate HBV genotyping system using RFLP is considered to be useful for research on HBV...
  3. ncbi request reprint Spread times of hepatitis C virus estimated by the molecular clock differ among Japan, the United States and Egypt in reflection of their distinct socioeconomic backgrounds
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Intervirology 49:28-36. 2006
    ..These studies should help foresee what will happen in the near future for HCV infection in a given country, time the future development of HCC and take measures for preventing it...
  4. ncbi request reprint Molecular evolutionary analysis predicts the incidence of hepatocellular carcinoma in the United States and Japan
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Cancer Chemother Pharmacol 54:S83-6. 2004
    ..If HCC is a function of increased HCV exposure time, the molecular clock predicts that the burden of HCC in the US will accelerate in the next two to three decades...
  5. ncbi request reprint Mutation patterns for two flaviviruses: hepatitis C virus and GB virus C/hepatitis G virus
    M Mizokami
    Second Department of Medicine, Nagoya City University Medical School, Nagoya, Japan
    FEBS Lett 450:294-8. 1999
    ....
  6. ncbi request reprint Lack of integrated TT virus (TTV) genomes in cellular DNA in infected human hematopoietic cells
    Y Tanaka
    Second Department of Medicine, Nagoya City University Medical School, Mizuho, Nagoya, Japan
    Leuk Lymphoma 38:411-7. 2000
    ..2-kb fragment derived from the TTV DNA, however, showed no evidence supporting the fact that the TTV genomes are integrated into the human hematopoietic cell genomes, thus suggesting their existence as episomal forms...
  7. ncbi request reprint Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China
    X Ding
    Second Department of Medicine, Nagoya City University School, Nagoya, Japan
    Intervirology 44:43-7. 2001
    ....
  8. ncbi request reprint Determination of hepatitis B virus genotype G by polymerase chain reaction with hemi-nested primers
    H Kato
    Second Department of Medicine, Nagoya City University Medical School, Nagoya 467-8601, Japan
    J Virol Methods 98:153-9. 2001
    ..A possible method for serological determination of hepatitis B surface antigen of genotype G is suggested, without amplification or sequencing nucleotides, which would expand epidemiological and clinical researches on HBV genotype G...
  9. ncbi request reprint A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: complete genome sequence and phylogenetic relatedness
    F Sugauchi
    Second Department of Internal Medicine and Laboratory Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, 467-8601 Nagoya, Japan
    J Gen Virol 82:883-92. 2001
    ..These results contribute to the investigation of the worldwide spread of HBV, the relationship between serotype and genotype and the ancient common origin of Australian Aborigines...
  10. ncbi request reprint Identification of a novel 23kDa protein encoded by putative open reading frame 2 of TT virus (TTV) genotype 1 different from the other genotypes
    Y Tanaka
    Second Department of Medicine, Nagoya City University Medical School, Japan
    Arch Virol 145:1385-98. 2000
    ..Our data indicate TTV G1a and a part of G1b should have different characteristics from the other genotypes...
  11. ncbi request reprint [Molecular evolution and genotype classification of TT virus]
    M Mizokami
    Second Department of Medicine, Nagoya City University Medical School
    Nihon Rinsho 57:1250-5. 1999
    ..Further studies using more than 350 isolates obtained from DDBJ showed at least nine genotypes...
  12. ncbi request reprint Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan
    E Orito
    Second Department of Medicine, Nagoya City University Medical School, Nagoya, Japan
    Hepatology 34:590-4. 2001
    ..01). These results indicate that genotypes C and B are predominant in Japan, and there are significant differences in geographic distribution and clinical characteristics among the patients with the different genotypes...
  13. ncbi request reprint Molecular evolution of hepatitis viruses
    M Mizokami
    Department of Blood Transfusion, and Second Department of Medicine, Nagoya City University Medical School, Nagoya, Japan
    Intervirology 42:159-65. 1999
    ..In addition, the evolution of the hepatitis virus is discussed by applying these methods to hepatitis B virus and hepatitis C virus...
  14. ncbi request reprint Tracing hepatitis C and Delta viruses to estimate their contribution in HCC rates in Mongolia
    F Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Viral Hepat 14:667-74. 2007
    ..Used approach is useful in evaluation of current and prospective disease burden...
  15. ncbi request reprint Effect of interferon therapy on Japanese chronic hepatitis C virus patients with anti-liver/kidney microsome autoantibody type 1
    Y Iijima
    Gastroenterology Section, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    J Gastroenterol Hepatol 16:782-8. 2001
    ....
  16. ncbi request reprint Quantification of red blood cell fragmentation by the automated hematology analyzer XE-2100 in patients with living donor liver transplantation
    S Banno
    Central Clinical Laboratory, Nagoya City University Hospital, Nagoya, Japan
    Clin Lab Haematol 27:292-6. 2005
    ..The determination of FRC count (%) by the XE-2100 that enables early diagnoses and monitoring of TTP or TMA will be useful in the clinical field...
  17. ncbi request reprint Identification and phylogenetic analysis of hepatitis C virus in forensic blood samples obtained from injecting drug users
    H Kato
    Department of Forensic Medical Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Forensic Sci Int 168:27-33. 2007
    ..HCV isolates identified in this study did not phylogenetically segregate, thus multiple transmission route of HCV among IDUs seems be exist in Japan...
  18. doi request reprint Mechanism of the dependence of hepatitis B virus genotype G on co-infection with other genotypes for viral replication
    T Sakamoto
    Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Viral Hepat 20:e27-36. 2013
    ..In conclusion, HBV/G could take advantage of core proteins from other genotypes during co-infection to replicate efficiently and to effectively package HBV DNA into virions...
  19. ncbi request reprint Mucosal immunization against hepatitis B virus by intranasal co-administration of recombinant hepatitis B surface antigen and recombinant cholera toxin B subunit as an adjuvant
    M Isaka
    Department of Microbiology, Nagoya City University Medical School, Mizuho-ku, 467-8601, Nagoya, Japan
    Vaccine 19:1460-6. 2001
    ....
  20. ncbi request reprint Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Hepatol 45:646-53. 2006
    ..Hepatitis B virus genotype C (HBV/C) has been classified into two geographically distinct subgenotypes; HBV/C1/Cs (Southeast Asia) and HBV/C2/Ce (East Asia)...
  21. ncbi request reprint Variations in the viral NS5B region in Japanese patients with chronic hepatitis C virus genotype 1b infection. No specific amino acid substitution was identified as determinants of treatment response to interferon/ribavirin combination therapy
    Kanji Sugihara
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, and Department of Gastroenterology, Nagoya Daini Red Cross Hospital, Japan
    Intervirology 49:319-26. 2006
    ....
  22. ncbi request reprint Novel subtypes (subgenotypes) of hepatitis B virus genotypes B and C among chronic liver disease patients in the Philippines
    Tomoyuki Sakamoto
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho, Nagoya 467 8601, Japan
    J Gen Virol 87:1873-82. 2006
    ..08; 95% CI 3.62-4.74; P<0.001) were significant factors for HCC development. In conclusion, novel HBV subtypes (subgenotypes) C5 and B5 are prevalent in the Philippines, as well as HBV/Aa (A1)...
  23. ncbi request reprint Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Gastroenterology 130:703-14. 2006
    ..This approach was combined with analyses of the hepatitis C virus (HCV) epidemiologic-historical background and HCV-related hepatocellular carcinoma (HCC) in different countries...
  24. ncbi request reprint Classifying genotype F of hepatitis B virus into F1 and F2 subtypes
    Hideaki Kato
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    World J Gastroenterol 11:6295-304. 2005
    ..To explore the propriety of providing hepatitis B virus (HBV) genotypes F and H with two distinct genotypes...
  25. ncbi request reprint T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection
    Kiyoaki Ito
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Infect Dis 42:1-7. 2006
    ....
  26. ncbi request reprint Tracing the history of hepatitis B virus genotype D in western Japan
    Kojiro Michitaka
    Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    J Med Virol 78:44-52. 2006
    ..From the history of the area and the genetic analysis, HBV/D in this area was speculated to be of Russian origin...
  27. ncbi request reprint Comparison between subgenomic replicons of hepatitis C virus genotypes 2a (JFH-1) and 1b (Con1 NK5.1)
    Michiko Miyamoto
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu shi, Tokyo 183 8526, Japan
    Intervirology 49:37-43. 2006
    ..Therefore, further investigation may be needed on more HCV isolates of diverse genotypes...
  28. ncbi request reprint Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
    Peter Simmonds
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh, United Kingdom
    Hepatology 42:962-73. 2005
    ..In conclusion, these proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future...
  29. ncbi request reprint High frequency of hepatocellular carcinoma in Mongolia; association with mono-, or co-infection with hepatitis C, B, and delta viruses
    Tsendsuren Oyunsuren
    Laboratory of Molecular Biology, The Institute of Biology, Mongolian Academy of Sciences, Ulaanbaatar, Mongolia
    J Med Virol 78:1688-95. 2006
    ..Liver tumor markers; AFP and PIVKA-II are useful tools for complex HCC-screening and clinical follow-up for chronic hepatitis patients in Mongolia...
  30. ncbi request reprint A reduction in selective immune pressure during the course of chronic hepatitis C correlates with diminished biochemical evidence of hepatic inflammation
    Kousuke Hanada
    National Institute of Genetics, Yata 1111, Mishima, Shizuoka, Japan
    Virology 361:27-33. 2007
    ..This observation may be applicable to other viruses characterized by a slow rate of disease progression...
  31. doi request reprint What can be revealed by extending the sensitivity of HBsAg detection to below the present limit?
    Hitoshi Togashi
    Department of Gastroenterology, Course of Internal Medicine and Therapeutics, Yamagata University Faculty of Medicine, Yamagata University Health Administration Center, 1 4 12 Kojirakawa machi, Yamagata 990 8560, Japan
    J Hepatol 49:17-24. 2008
    ..We investigated what can be revealed by extending the sensitivity of HBsAg detection to below the present limit...
  32. doi request reprint Virological and clinical implication of core promoter C1752/V1753 and T1764/G1766 mutations in hepatitis B virus genotype D infection in Mongolia
    Abeer Elkady
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 23:474-81. 2008
    ..The aim of the present study was to reveal virological and clinical features of hepatitis B virus (HBV) genotype D infection...
  33. ncbi request reprint [Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay]
    Kentaro Matsuura
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya
    Rinsho Byori 55:983-8. 2007
    ..100% at W4), (100% vs. 100% at W8), (83.3% vs. 72.7% at W12). HCV RNA undetectable at W12 had a higher PPV for SVR when measured by RTD-PCR than by conventional PCR...
  34. ncbi request reprint Epidemiological and clinical evaluation of hepatitis B, hepatitis C, and delta hepatitis viruses in Tajikistan
    Anis Khan
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan
    J Med Virol 80:268-76. 2008
    ..0004). This is the first study on the molecular epidemiology of hepatitis viruses among chronic liver diseases patients in Tajikistan. Among HBV-infected patients, the T1762/A1764 mutation was associated with liver cirrhosis/HCC...
  35. ncbi request reprint Hepatitis B virus transmission pattern and vaccination efficiency in Uzbekistan
    Dildora Avazova
    National Reference Laboratory, Ministry of Public Health, Tashkent, Uzbekistan
    J Med Virol 80:217-24. 2008
    ..In conclusion, HBV universal vaccination is efficient in Uzbekistan irrespective of the vaccine formulation used, because the horizontal transmission pattern predominates currently in this endemic region...
  36. ncbi request reprint Comparison of complete sequences of hepatitis B virus genotype C between inactive carriers and hepatocellular carcinoma patients before and after seroconversion
    Kiyoaki Ito
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Gastroenterol 42:837-44. 2007
    ..The aim of this study was to investigate the HCC-related mutations of HBV...
  37. ncbi request reprint Increasing genetic diversity of hepatitis C virus in haemophiliacs with human immunodeficiency virus coinfection
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Gen Virol 88:2513-9. 2007
    ..In conclusion, HIV-positive patients would have a more diversified HCV population than HIV-negative patients due to less selective pressure from the immune system...
  38. ncbi request reprint Variations in the core promoter/pre-core region in HBV genotype C in Japanese and Northern Vietnamese patients
    Bui Xuan Truong
    Kobe University Graduate School of Medicine, Clinical Molecular Medicine, Kobe, Japan
    J Med Virol 79:1293-304. 2007
    ..The subgenotypes and unique mutations of HBV genotype C in the Vietnamese and Japanese differed, and C/A1753 and C1858 variants might play a role in the pathogenesis of liver disease in Vietnamese patients...
  39. pmc The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells
    Asako Murayama
    Department of Virology II, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku, Tokyo 162 8640, Japan
    J Virol 81:8030-40. 2007
    ..In conclusion, the JFH-1 NS3 helicase and NS5B-to-3'X regions are important for efficient replication and virus particle formation of HCV genotype 2a strains...
  40. ncbi request reprint A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan
    Atsunori Kusakabe
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Aichi, 467 8601, Japan
    J Gastroenterol 42:298-305. 2007
    ..e., they constitute the so-called category of non-B non-C (NBNC) HCC. Little is known about the characteristics of NBNC-HCC...
  41. ncbi request reprint Hepatitis B virus (HBV) genotypes/subgenotypes in China: mutations in core promoter and precore/core and their clinical implications
    Jing Yuan
    Shenzhen East Lake Hospital, Shenzhen, China
    J Clin Virol 39:87-93. 2007
    ..The association of hepatitis B virus (HBV) genotypes with clinical course of infection is increasingly recognized...
  42. pmc Clinical and virological characteristics of hepatitis B virus subgenotypes Ba, C1, and C2 in China
    Zhanhui Wang
    Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    J Clin Microbiol 45:1491-6. 2007
    ..Therefore, genotyping and detecting the 1653T and 1753V mutations, in addition to the A1762T G1764A double mutation, might have important clinical implications as predictive risk factors for hepatocarcinogenesis...
  43. ncbi request reprint Molecular epidemiological study of hepatitis B virus infection in two different ethnic populations from the Solomon Islands
    Takako Utsumi
    Department of International and Environmental Medical Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
    J Med Virol 79:229-35. 2007
    ..HBeAg appears to clear from the serum in young adulthood in HBV/D infection, which may be influenced by genotype-dependent features in relation to viral mutations...
  44. ncbi request reprint [Clinical examinations based on nucleic acids of hepatitis viruses]
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya
    Rinsho Byori 54:1164-71. 2006
    ..Here, we summarize examinations based on viral nucleic acids and the clinical manifestations of HBV and HCV genotypes...
  45. pmc Molecular evolution of hepatitis B virus over 25 years
    Carla Osiowy
    Public Health Agency of Canada, National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba R3E 3P6, Canada
    J Virol 80:10307-14. 2006
    ..The results of this study suggest that HBV sequence divergence may occur more rapidly than previously estimated, in a host immune phase-dependent manner...
  46. pmc Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    Takaji Wakita
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Nat Med 11:791-6. 2005
    ..The cell culture-generated HCV is infectious for chimpanzee. This system provides a powerful tool for studying the viral life cycle and developing antiviral strategies...
  47. ncbi request reprint Differences of hepatocellular carcinoma patients with hepatitis B virus genotypes of Ba, Bj or C in Japan
    Etsuro Orito
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi I, Mizuho, Nagoya 467 8601, Japan
    Intervirology 48:239-45. 2005
    ..5% of those aged older than 50 years had cirrhosis. These data suggest that great differences exist among patients with HCC infected with different genotypes...
  48. ncbi request reprint Evaluation of loss of heterozygosity before and after interferon therapy in patients with hepatitis C virus infection who developed hepatocellular carcinoma during follow up
    Seiji Suzuki
    Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 18:1364-72. 2003
    ....
  49. ncbi request reprint Transforming growth factor-beta-1 genetic polymorphism in Japanese patients with chronic hepatitis C virus infection
    Seiji Suzuki
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 18:1139-43. 2003
    ..The aim of the present study was to examine the effects of TGF-beta1 polymorphisms in Japanese patients with chronic hepatitis C virus (HCV) infection and in healthy control subjects...
  50. ncbi request reprint Loss of hepatitis C virus RNA after parturition in female patients with chronic HCV infection
    Yuko Hattori
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 71:205-11. 2003
    ..03). Significantly more pregnant patients lost HCV RNA than did nonpregnant controls. These findings suggest that pregnancy and parturition appear to influence the clinical course of HCV infection...
  51. ncbi request reprint Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease
    Fuminaka Sugauchi
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 70:537-44. 2003
    ..These results indicate that the development of preS deletion mutants depends on HBV genotypes and that it may be associated with progressive liver disease...
  52. ncbi request reprint Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: a prospective study
    Tomokuni Nakayoshi
    Department of Internal Medicine, Yonabaru Central Hospital, Okinawa, Japan
    J Med Virol 70:350-4. 2003
    ..Thus, HBV genotypes may influence the prognosis of HBV-related chronic liver disease...
  53. ncbi request reprint Impact of interleukin-1beta genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Infect Dis 187:1822-5. 2003
    ....
  54. ncbi request reprint Distribution of hepatitis B virus (HBV) genotypes among HBV carriers in the Cote d'Ivoire: complete genome sequence and phylogenetic relatedness of HBV genotype E
    Seiji Suzuki
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Japan
    J Med Virol 69:459-65. 2003
    ....
  55. ncbi request reprint Hepatitis C virus molecular epidemiology in Uzbekistan
    Fuat Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 69:367-75. 2003
    ....
  56. ncbi request reprint Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China
    Shun Zhang Yu
    Department of Epidemiology, Shanghai Medical University, Shanghai, P R of China
    Jpn J Cancer Res 93:1287-92. 2002
    ....
  57. pmc A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades
    Yasuhito Tanaka
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:15584-9. 2002
    ..These estimates of viral spread time are consistent with epidemiologic observations and predict that the burden of HCC in the U.S. will increase in the next two to three decades, possibly to equal that currently experienced in Japan...
  58. ncbi request reprint Genotype, serotype, and phylogenetic characterization of the complete genome sequence of hepatitis B virus isolates from Malawian chronic carriers of the virus
    Fuminaka Sugauchi
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 69:33-40. 2003
    ....
  59. ncbi request reprint Preponderance of hepatitis B virus genotype B contributes to a better prognosis of chronic HBV infection in Okinawa, Japan
    Hiroshi Sakugawa
    First Department of Internal Medicine, University Hospital, Faculty of Medicine, University of the Ryukyus, Uehara, Okinawa, Japan
    J Med Virol 67:484-9. 2002
    ..These findings suggest that the preponderance of genotype B is responsible for the low mortality rate of primary liver cancer associated with HBV seen in Okinawa Prefecture, despite having the highest HBV carrier rate in Japanese...
  60. ncbi request reprint Hepatitis B virus genotypes in Uzbekistan and validity of two different systems for genotyping
    Hideaki Kato
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Japan
    J Med Virol 67:477-83. 2002
    ..No significant difference of ALT level (203.3 +/- 244.7 vs. 190.6 +/- 39.5) and HBeAg (42.9% vs. 42.6%) were found between genotypes A and D. In this study, the validity of the genotyping systems in this region was confirmed...
  61. ncbi request reprint Hepatitis B virus genotypes and clinical manifestation among hepatitis B carriers in Thailand
    Fuminaka Sugauchi
    Second Department of Internal Medicine and Department of Laboratory Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Gastroenterol Hepatol 17:671-6. 2002
    ..Hepatitis B virus (HBV) genotypes have distinct geographic distributions. The aim of the present study was to evaluate the distribution of HBV genotypes and their clinical relevance in Thailand...
  62. ncbi request reprint Hepatitis B virus genotypes and hepatocellular carcinoma in Japan
    Etsuro Orito
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho, Nagoya 467 8601, Japan
    Intervirology 46:408-12. 2003
    ....
  63. ncbi request reprint Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon
    Takanobu Kato
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    Gastroenterology 125:1808-17. 2003
    ..To develop a new replicon system, the genotype 2a clone JFH-1 was isolated from a patient with fulminant hepatitis...
  64. ncbi request reprint Impact of occult hepatitis B virus infection on efficacy and prognosis of interferon-alpha therapy for patients with chronic hepatitis C
    Izumi Hasegawa
    Department of Internal Medicine, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Liver Int 25:247-53. 2005
    ..The aim of this study was to elucidate the impact of occult HBV infection on the efficacy and prognosis of interferon-alpha (IFN) therapy in HCV patients...
  65. ncbi request reprint New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0
    Motokazu Mukaide
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Science, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    World J Gastroenterol 11:469-75. 2005
    ..0 (microwell version)...
  66. ncbi request reprint Molecular evolutionary analyses implicate injection treatment for schistosomiasis in the initial hepatitis C epidemics in Japan
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Hepatol 42:47-53. 2005
    ..Our aim was to estimate the spread time of hepatitis C virus (HCV) infection in the past with possible relevance to a higher incidence of HCC in once Sj-endemic than Sj-nonendemic areas...
  67. ncbi request reprint Molecular epidemiologic analysis of hepatitis C virus infection in injecting drug users with acute hepatitis C in Japan
    Yasuhiro Satoh
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Ube, Japan
    J Gastroenterol Hepatol 19:1305-11. 2004
    ....
  68. ncbi request reprint Analysis of HCV genotypes from blood donors shows three new HCV type 6 subgroups exist in Myanmar
    Toshiyuki Shinji
    Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 58:135-42. 2004
    ..M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed...
  69. ncbi request reprint [Mutation of HCV-RNA and determination of its genome by RT-PCR]
    Takanobu Kato
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 62:236-40. 2004
  70. ncbi request reprint [Molecular evolutionary analysis of hepatitis C virus--detection of positive selective sites]
    Masashi Mizokami
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 62:76-80. 2004
  71. ncbi request reprint Eight genotypes (A-H) of hepatitis B virus infecting patients from San Francisco and their demographic, clinical, and virological characteristics
    Hideaki Kato
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 73:516-21. 2004
    ..HBV genotype H might be identified by combination of preS2 serotpe bksf and HBsAg serotype adw...
  72. pmc Novel hepatitis B virus genotype a subtyping assay that distinguishes subtype Aa from Ae and its application in epidemiological studies
    Izumi Hasegawa
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Virol 78:7575-81. 2004
    ..In conclusion, the specificity and sensitivity of the combined subtyping assay were confirmed, and its usefulness was demonstrated in a practical context...
  73. ncbi request reprint Reliability of hepatitis C virus core antigen assay for detection of viremia in HCV genotypes 1, 2, 3, and 4 infected blood donors: a collaborative study between Japan, Egypt, and Uzbekistan
    Salah Agha
    Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    J Med Virol 73:216-22. 2004
    ..No specific mutation was found in the core-encoding region of the studied specimens. In conclusion, HCVcAg is shown to be specific, sensitive, and informative qualitative index for HCV viremia in asymptomatic carriers...
  74. ncbi request reprint Exponential spread of hepatitis C virus genotype 4a in Egypt
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Science, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    J Mol Evol 58:191-5. 2004
    ..In conclusion, the estimated spread time is consistent with the duration of intravenous antimony campaigns in Egypt...
  75. ncbi request reprint Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype A
    Fuminaka Sugauchi
    Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gen Virol 85:811-20. 2004
    ..Subtypes Aa and Ae of genotype A deserve evaluation for any clinical differences between them, with a special reference to hepatocellular carcinoma prevalent in Africa...
  76. ncbi request reprint Genotype 2a hepatitis C virus subgenomic replicon can replicate in HepG2 and IMY-N9 cells
    Tomoko Date
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    J Biol Chem 279:22371-6. 2004
    ..This system with the JFH-1 replicon and three cell lines is useful not only for estimating the cellular factors affecting viral activity but also for clarifying the common gene response of the host...
  77. ncbi request reprint Comparison of genotypes C and D of the hepatitis B virus in Japan: a clinical and molecular biological study
    Tran Nhu Duong
    Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    J Med Virol 72:551-7. 2004
    ..Thus, the outcome of chronic HBV infection may be different in persons infected with HBV genotypes C and D...
  78. ncbi request reprint Chronic hepatitis C infection: influence of the viral load, genotypes, and GBV-C/HGV coinfection on the severity of the disease in a Brazilian population
    Leila M M B Pereira
    Department of Internal Medicine, University of Pernambuco, Recife PE, Brazil
    J Med Virol 67:27-32. 2002
    ..There were no significant differences between patients with the predominant HCV genotypes (1b and 3) with respect to gender, age group, viral load, severity of liver disease, or coinfection with GBV-C/HGV...