Tetsuya Matsuguchi

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes
    T Matsuguchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Blood 95:1378-85. 2000
  2. pmc JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation
    Tetsuya Matsuguchi
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    EMBO J 22:4455-64. 2003
  3. pmc Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through Toll-like receptor 2
    Tetsuya Matsuguchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Diagn Lab Immunol 10:259-66. 2003
  4. ncbi request reprint Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages
    T Matsuguchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Immunol 165:5767-72. 2000
  5. pmc A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines
    T Matsuguchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Mol Cell Biol 21:6999-7009. 2001
  6. ncbi request reprint Soluble branched beta-(1,4)glucans from Acetobacter species show strong activities to induce interleukin-12 in vitro and inhibit T-helper 2 cellular response with immunoglobulin E production in vivo
    Kimika Saito
    Division of Host Defense, Research Center of Prevention of Infectious Disease, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 278:38571-8. 2003
  7. ncbi request reprint Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways
    Akio Masuda
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Immunol 169:3801-10. 2002
  8. ncbi request reprint NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice
    Takashi Hiromatsu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Eur J Immunol 33:2511-9. 2003
  9. ncbi request reprint Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice
    Hideyuki Shimizu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Gastroenterology 123:1265-77. 2002
  10. ncbi request reprint Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages
    Tipayaratn Musikacharoen
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Biol Chem 278:9167-75. 2003

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes
    T Matsuguchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Blood 95:1378-85. 2000
    ..Our results indicate that both mTLR2 and mTLR4 are involved in LPS signaling, but their expressions are regulated differently in T cells, and that LPS may directly affect T-cell functions by binding to TLRs. (Blood. 2000;95:1378-1385)..
  2. pmc JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation
    Tetsuya Matsuguchi
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    EMBO J 22:4455-64. 2003
    ..7 cells, JIP3 associates MEKK-1, but not with TAK-1. Finally, JIP3 also associates with TLR2 and TLR9, but not with TLR1 or TLR6. Altogether, our data indicate the involvement of JIP3 in JNK activation in downstream signals of some TLRs...
  3. pmc Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through Toll-like receptor 2
    Tetsuya Matsuguchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Diagn Lab Immunol 10:259-66. 2003
    ..Taken together, these data suggest that LTAs from lactobacilli elicit proinflammatory activities through TLR2...
  4. ncbi request reprint Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages
    T Matsuguchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Immunol 165:5767-72. 2000
    ..Taken together, our results indicate that TLR2, in contrast to TLR4, can be induced in macrophages in response to bacterial infections and may accelerate the innate immunity against pathogens...
  5. pmc A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines
    T Matsuguchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Mol Cell Biol 21:6999-7009. 2001
    ....
  6. ncbi request reprint Soluble branched beta-(1,4)glucans from Acetobacter species show strong activities to induce interleukin-12 in vitro and inhibit T-helper 2 cellular response with immunoglobulin E production in vivo
    Kimika Saito
    Division of Host Defense, Research Center of Prevention of Infectious Disease, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 278:38571-8. 2003
    ..AC-1, a soluble branched beta-(1,4)glucan may be useful in prevention and treatment of allergic disorders With IgE production...
  7. ncbi request reprint Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways
    Akio Masuda
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Immunol 169:3801-10. 2002
    ..Our findings may indicate a clue to understanding the mechanisms of how bacteria infection worsens the clinical features of asthma...
  8. ncbi request reprint NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice
    Takashi Hiromatsu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Eur J Immunol 33:2511-9. 2003
    ..In conclusion, it is suggested that induction of Fas L on NK T cells in response to bacterial components such as lipoproteins plays an important role in pathogenesis of E. coli-induced liver injury in mice...
  9. ncbi request reprint Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice
    Hideyuki Shimizu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Gastroenterology 123:1265-77. 2002
    ..In the present study, we investigated whether TLRs on NKT cells are involved in Salmonella-induced liver injury...
  10. ncbi request reprint Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages
    Tipayaratn Musikacharoen
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Biol Chem 278:9167-75. 2003
    ..Altogether, our data indicated that the activation of mkp-M gene transcription in macrophages by LPS is associated with histone acetylation and chromatin remodeling...
  11. ncbi request reprint Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells
    Naotake Tsuboi
    Department of Internal Medicine, Division of Nephrology, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 169:2026-33. 2002
    ..Thus, MTECs have a distinct expression pattern of TLR and secrete C-C chemokines in response to direct stimulation with a set of bacterial components...
  12. ncbi request reprint Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice
    Tetsuya Abe
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Hepatology 40:414-23. 2004
    ..Fas-mediated hepatocyte apoptosis in cholestasis may be involved in the predominant IL-10 production by Kupffer cells...
  13. ncbi request reprint Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells
    Norika Chiba
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Cell Physiol 213:126-36. 2007
    ..Thus, ceramide appeared to down-regulate LPS-stimulated production of IL-5, IL-10, and IL-13 from mast cells by inhibiting PI3 kinase-Akt pathway in a cell type-specific manner...
  14. ncbi request reprint Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4
    Sawako Kato
    Division of Clinical Immunology, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Soc Nephrol 15:1289-99. 2004
    ..The results provide a candidate molecular target in prevention of it...
  15. ncbi request reprint The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells
    Akio Masuda
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 173:5564-73. 2004
    ..The results of the present study have shown that direct interaction between AP-1 and GATA proteins plays an important role in IL-13 transcription in mast cells...
  16. doi request reprint Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells
    Shino Kumabe
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    Microbiol Immunol 54:105-11. 2010
    ..These results suggest that DUSP16 is an important regulator of JNK activity and effector functions of CD4 and CD8 T cells...
  17. doi request reprint Serine/threonine kinase, Cot/Tpl2, regulates renal cell apoptosis in ischaemia/reperfusion injury
    Takaaki Yaomura
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nephrology (Carlton) 13:397-404. 2008
    ..At the same time, it is also related to the caspase-dependent apoptotic pathway. Thus, the role of Cot/Tpl2 in ischaemia/reperfusion injury (IRI) in which TNF-alpha and apoptosis are the major pathogenetic factors was studied...
  18. pmc Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB/c and C57BL/6 mice
    Tie Liu
    Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, Japan
    Infect Immun 70:6638-45. 2002
    ..Differences in reactivities of DC to microbial molecules through TLRs may be associated with susceptibility and resistance to Listeria infection in BALB/c and C57BL/6 mice...
  19. ncbi request reprint Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis
    Takashi Hiromatsu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Infect Dis 187:1442-51. 2003
    ..coli challenge. These results suggest that IL-15 overexpression can prevent TNF-alpha-induced apoptosis and protect against E. coli-induced shock, indicating a possible therapeutic application of IL-15 for septic shock...
  20. pmc A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation
    Kenji Sugimoto
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Japan
    J Clin Invest 114:857-66. 2004
    ....
  21. ncbi request reprint [Toll-like receptor signals and innate immunity]
    Tetsuya Matsuguchi
    Laboratory of Hostdefense, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550
    Seikagaku 74:1463-8. 2002
  22. ncbi request reprint Essential role of GATA transcriptional factors in the activation of mast cells
    Akio Masuda
    Division of Neurogenetics and Bioinformatics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 178:360-8. 2007
    ..Signal transduction and histone modification in the chromatin related to protein kinase Cbeta were defective in these cells. These results identify that GATA has a critical role in the activation of mast cell...
  23. pmc CD8 alpha-deficient mice are highly susceptible to 5-fluorouracil-induced lethality
    Naoto Itoh
    Laboratory of Host Defense, Research Institute for Disease Mechanisms and Control, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Clin Diagn Lab Immunol 9:550-7. 2002
    ..The results suggest that CD8(+) i-IEL play an important role in protection against 5-FU-induced lethality with translocation of Enterobacteriaceae...
  24. ncbi request reprint Mature hepatocyte growth factor/scatter factor on the surface of human granulocytes is released by a mechanism involving activated factor Xa
    Tomokazu Ohnishi
    Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    J Immunol 176:6945-53. 2006
    ..Thus, human granulocytes may function as a transporter of HGF in the peripheral blood, releasing HGF at the injured sites caused by blood coagulation, where HGF may promote tissue repair...
  25. ncbi request reprint [Signal transduction of Toll-like receptors]
    Tetsuya Matsuguchi
    Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
    Nihon Rinsho 63:109-14. 2005
  26. ncbi request reprint Impaired recognition by Toll-like receptor 4 is responsible for exacerbated murine Pneumocystis pneumonia
    Kai Ding
    Division of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    Microbes Infect 7:195-203. 2005
    ..Taken together, these findings suggest that recognition of Pneumocystis by TLR4 helps to regulate the host inflammatory responses through cytokine and chemokine production by alveolar macrophages...
  27. ncbi request reprint Antitumor activity and action mechanisms of Lactobacillus casei through the regulation of immune responses
    Takeshi Matsuzaki
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi shi, Tokyo 186 8650, Japan
    Biofactors 22:63-6. 2004
    ....
  28. ncbi request reprint Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling
    Tipayaratn Musikacharoen
    Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Blood 105:711-20. 2005
    ..Thus, IL-15 induces chromatin remodeling of the IL12RB1 gene promoter, increasing IL12RB1 mRNA expression in synergy with IFN-gamma through the recruitment of PU.1 and IRF3...
  29. pmc Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression
    Marcela A Hermoso
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 24:4743-56. 2004
    ..Together, these studies define novel signaling mechanism for these three transcription factors, with a profound impact on discrimination of innate and adaptive immune responses...
  30. ncbi request reprint Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris
    Takashi Hasegawa
    Research Laboratories, Chlorella Industry Co, Ltd, Chikugo City, Fukuoka, Japan
    Int Immunopharmacol 2:579-89. 2002
    ..These results suggest that TLR2 signaling is at least partly involved in the antitumor activity of the water-soluble antitumor glycoprotein from C. vulgaris...
  31. ncbi request reprint Interstrand crosslink-induced homologous recombination carries an increased risk of deletions and insertions
    Vidya S Jonnalagadda
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Ave, 56 631, Cambridge, MA 02139, USA
    DNA Repair (Amst) 4:594-605. 2005
    ..Given that many chemotherapeutics induce ICLs, these results have important implications in terms of the risk of chemotherapy-induced deleterious sequence rearrangements that could potentially contribute to secondary tumors...
  32. ncbi request reprint Low-intensity pulsed ultrasound (LIPUS) induces RANKL, MCP-1, and MIP-1beta expression in osteoblasts through the angiotensin II type 1 receptor
    Kenjiro Bandow
    Department of Biochemistry and Molecular Dentistry, Field of Developmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Cell Physiol 211:392-8. 2007
    ..Thus, AT1 may play one of the essential roles in bone metabolism as a mechanoreceptor of osteoblasts...
  33. pmc Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases
    Erik J Spek
    Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Bacteriol 184:3501-7. 2002
    ..These studies shed light on the underlying mechanism of NO*-induced homologous recombination...