Research Topics
Genomes and Genes | S MatsudaSummaryAffiliation: Nagoya University Country: Japan Publications
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Publications
Intercept-PCR, an improvement for elevating performance to find a new member of a certain gene familyS Matsuda
Nagoya University School of Medicine, Dep Mol Pathogen, Japan
Mol Biotechnol 16:1-4. 2000..To verify the effectiveness of this method is also easy: it is only to detect the PCR products in the preliminary experiment. The finding in the present study provides valuable information for gene cloning tactics...- In search of a function for the TIS21/PC3/BTG1/TOB familyS Matsuda
Department of Molecular Pathogenesis, Nagoya University School of Medicine, Japan
FEBS Lett 497:67-72. 2001..It is now emerging that every member of this family has a potential to regulate cell growth. We would like to propose here to use a nomenclature APRO as a new term for the family... - Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3S Matsuda
Department of Molecular Pathogenesis, Nagoya University School of Medicine, Japan
J Hum Genet 46:483-6. 2001..Polymerase Chair reaction-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels localized the gene on human chromosome 3q12 near the marker D3S1271... - Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 proteinK Miyazaki
Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Biochim Biophys Acta 1493:237-41. 2000..PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 17q21.3 near the marker D17S1795... - Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3S Matsuda
Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
Biochim Biophys Acta 1491:321-6. 2000..PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 1q21-22... 
Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific mannerY Sohara
Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
Mol Biol Cell 12:1859-68. 2001....- Invasion activating caveolin-1 mutation in human scirrhous breast cancersK Hayashi
Department of Molecular Pathogenesis, Nagoya University School of Medicine, Japan
Cancer Res 61:2361-4. 2001..These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer... - Cloning and sequencing of a novel human gene which encodes a putative hydroxylaseC Iriyama
Department of Molecular Pathogenesis, Nagoya University School of Medicine, Japan
J Hum Genet 46:289-92. 2001..Polymerase chain reaction-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 10q21.1 near the marker D10S210... - p73 is highly expressed in myoepithelial cells and in carcinomas with metaplasiaT Yamamoto
First Department of Surgery, Nagoya University School of Medicine, Nagoya 466-8550, Japan
Int J Oncol 19:271-6. 2001..The findings in the present study provide valuable information on the characteristics of myoepithelial cells... - Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancerS Matsuda
Department of Molecular Pathogenesis, Nagoya University School of Medicine, Japan
Cancer Res 60:13-7. 2000..Radiation hybrid mapping placed the gene into human chromosome 12q11-12 near the marker D12S1593... - Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein familyY Ichigotani
Department of Molecular Pathogenesis, Nagoya University School of Medicine, Japan
J Hum Genet 45:378-82. 2000..Polymerase chain reaction (PCR)-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 20p13 near the marker D20S906... - Molecular cloning of macrophin, a human homologue of Drosophila kakapo with a close structural similarity to plectin and dystrophinT Okuda
Department of Radiology, Department of Molecular Pathogenesis, Pathology II, Nagoya University School of Medicine, 65 Turumai cho, Showa Ku, Nagoya, 466 8550, Japan
Biochem Biophys Res Commun 264:568-74. 1999..In pancreas, we found that macrophin was specifically expressed in acinar cells than islet cells by in situ hybridization. By using radiation hybrid panel, we have mapped the macrophin gene to the chromosome 1p31-32... - Suppression of cell spreading by v-Crk requires Ras-MEK-MAP kinase signalingY Liu
Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
Oncogene 20:5908-12. 2001..Taken together, our results suggest that, among multiple signaling pathways activated by v-Crk, the Ras-MEK1-MAP kinase cascade plays a pivotal role in the suppression of cell spreading on fibronectin, but C3G and the PI3 kinase do not... - Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activityS Matsuda
Department of Oncology, University of Tokyo, Japan
Oncogene 12:705-13. 1996.... - Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPFY Gotoh
Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
EMBO J 10:2661-8. 1991..These results suggest that MAP kinase functions as an intermediate between MPF and the interphase-M phase transition of microtubule organization... - Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancerT Yamauchi
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113, Japan
J Biol Chem 275:33937-44. 2000..The identification of this novel cross-talk between ErbB-2 and the autocrine growth stimulatory loop for PRL may provide new targets for therapeutic and preventive intervention of human breast cancer... - Insulin receptor substrate protein 53 (IRSp53) as a binding partner of antimetastasis molecule NESH, a member of Abelson interactor protein familyS Matsuda
Ann Oncol 19:1356-7. 2008 - Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G(1)regulatory genesY Matsumoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Br J Cancer 84:768-75. 2001.... - Cloning and characterization of the mouse tob geneY Yoshida
Department of Oncology, The Institute of Medical Science, University of Tokyo, Minato ku, Japan
Gene 191:109-13. 1997..This, together with the conserved sequence and expression pattern of tob between mouse and human, suggests that Tob plays an important role in the response to extracellular signals... - c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNKS Matsuda
Department of Pharmacology and Neurosciences, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
J Neurosci 21:6597-607. 2001..These data indicate that JIP-1b/IB1 scaffolds APP with JNK, providing a novel insight into the role of the JNK scaffold protein as an interface of APP with intracellular functional molecules... - Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide geneY Ogawa
Department of Medicine, Kyoto University School of Medicine, Japan
J Clin Invest 93:1911-21. 1994..The present study demonstrates that these mice provide a useful model system with which to assess the roles of BNP in cardiovascular regulation and suggests the potential usefulness of BNP as a long-term therapeutic agent... - Molecular cloning and characterization of Byp, a murine receptor-type tyrosine phosphatase similar to human DEP-1S Kuramochi
Institute of Medical Science, University of Tokyo, Japan
FEBS Lett 378:7-14. 1996..Finally, the byp gene was located to mouse chromosome 2E1-2 and rat chromosome 3q32-33... - ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous systemY Yoshida
Department of Oncology, The Institute of Medical Science, The University of Tokyo, Japan
Oncogene 16:2687-93. 1998..Finally, overexpression of ANA impaired serum-induced cell cycle progression from the G0/G1 to S phase. In conclusion, ANA is a fourth member of the Tob/BTG1 family that might play roles in neurogenesis in the central nervous system... - Small GTP-binding protein, Rho, both increased and decreased cellular motility, activation of matrix metalloproteinase 2 and invasion of human osteosarcoma cellsY Matsumoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan
Jpn J Cancer Res 92:429-38. 2001..In conclusion, we suggest that Rho has a dual effect on the invasion of osteosarcoma cells by modulating the motility, the ability to degrade ECM and tyrosine phosphorylation of FAK... - Low-grade fibromyxoid sarcoma versus low-grade myxofibrosarcoma in the extremities and trunk. A comparison of clinicopathological and immunohistochemical featuresY Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Histopathology 45:29-38. 2004.... - E-cadherin gene mutations frequently occur in synovial sarcoma as a determinant of histological featuresT Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Am J Pathol 159:2117-24. 2001..Thus, E-cadherin gene mutation may be one of the determinants of histological subtype in synovial sarcoma... - ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblastsM Sano
Cardiopulmonary Division, Department of Internal Medicine, KeioUniversity School of Medicine, Shinjuku, Tokyo, Japan
Circ Res 89:661-9. 2001.... - beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumoursT Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pathol 195:222-8. 2001..In addition, beta-catenin mutations in desmoid tumours occurred at an unusually wide range of sites within the gene... - The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosisS Ueno
Department of Neuropsychiatry, Ehime University School of Medicine, Shigenobu, Ehime, Japan
Nat Genet 28:121-2. 2001..We found a deletion in the coding region of the cDNA leading to a frame shift resulting in the production of a truncated protein in both alleles of patients and in single alleles of obligate carriers... - H-ras oncogene mutation in dedifferentiated chondrosarcoma: polymerase chain reaction-restriction fragment length polymorphism analysisA Sakamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 14:343-9. 2001..068). Our results would seem to suggest that H-ras mutation may occur during the course of dedifferentiation and may also have some effect on malignant potential... - A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein TobT Suzuki
Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Genes Cells 6:131-8. 2001..The growth suppression is hampered by the presence of activated ErbB2 kinase. The molecular mechanisms by which Tob suppresses cell growth and by which ErbB2 abrogates Tob function remain to be elucidated... - Production and characterization of a fragment containing the HIV-gp120 binding region of CD4 using a bovine papilloma virus (BPV) vectorM Gidlund
Department of Immunology, Karolinska Institute, Stockholm, Sweden
Arch Virol 113:209-19. 1990.... - Evidence for multiple activators for stress-activated protein kinase/c-Jun amino-terminal kinases. Existence of novel activatorsT Moriguchi
Department of Genetics and Molecular Biology, Kyoto University, Japan
J Biol Chem 270:12969-72. 1995..These results indicate the existence of multiple activators for SAPK/JNK; one is XMEK2/SEK1/MKK4, and the others are previously undescribed factors... - Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4K Nagata
Department of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science, Japan
EMBO J 13:3517-23. 1994..The structure should provide a basis for the structure-activity relationship of HRGs and for the design of drugs which prevent progression of breast cancer... - Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNAT Hada
Department of Biochemistry, Tokushima University, School of Medicine, Japan
Biochim Biophys Acta 1211:221-8. 1994..The predominant presence of 12-lipoxygenase mRNA in pineal gland was confirmed by in situ hybridization of rat brain. Significant amounts of 12-lipoxygenase mRNA were also detected in rat spleen, aorta, lung and leukocytes... - A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodiesA Fujimoto-Nishiyama
Department of Oncology, Institute of Medical Science, University of Tokyo, Japan
Gene 195:267-75. 1997..Further characterization of Finb would unravel an important role of nuclear body-involved transcriptional regulation... - Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase that is specifically expressed in spermatocytesM Ohsugi
Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku Tokyo 108, Japan
J Biol Chem 272:33092-9. 1997..Thus, Typ is a new member of the cytoplasmic protein-tyrosine phosphatases that may play an important role(s) in spermatogenesis and/or meiosis... - A novel subtype of G-protein-coupled receptor kinase, GRK7, in teleost cone photoreceptorsO Hisatomi
Department of Earth and Space Science, Graduate School of Science, Osaka University, Japan
FEBS Lett 424:159-64. 1998..Our result are consistent with the concept that lower vertebrates have rod- and cone-specific opsin kinases... - Molecular cloning and sequence analysis of two endoinulinase genes from Aspergillus nigerK Ohta
Department of Biological Resource Sciences, Faculty of Agriculture, Miyazaki University, Japan
Biosci Biotechnol Biochem 62:1731-8. 1998..The deduced amino acid sequences of the mature A. niger enzymes showed 73% identity with that of the Penicillium purpurogenum endoinulinase... - Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting proteinS Matsuda
Laboratory for Memory and Learning, RIKEN Brain Science Institute, Saitama, Japan
J Neurochem 73:1765-8. 1999..This result suggests that modulation of serine-880 phosphorylation in GluR2 controls the clustering of AMPA receptors at excitatory synapses and consequently contributes to synaptic plasticity... - Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicaseS Matsuda
Department of Molecular Pathogenesis Nagoya University School of Medicine, Japan
Biochim Biophys Acta 1490:163-9. 2000..8, it might be a human homolog of the K12H4.8. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 14q31 near the marker D14S605... - Chemokine receptor-usage of clinical HIV-1 isolates obtained from patients with HIV-1 infection in late clinical stages using PHA-blastS Matsuda
Institute of Clinical Research, Kure National Hospital, Hiroshima, Japan
Microbiol Immunol 43:967-74. 1999.... - H-ras oncogene mutation in dedifferentiated liposarcoma. Polymerase chain reaction-restriction fragment length polymorphism analysisA Sakamoto
Departments of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Am J Clin Pathol 115:235-42. 2001..Our results seem to suggest that the H-ras mutation is a relatively uncommon event in dedifferentiated liposarcoma, which may demonstrate an epiphenomenon of dedifferentiation in dedifferentiated liposarcoma... - Molecular cloning of feline interferon cDNA by direct expressionN Nakamura
Basic Research Laboratories, Toray Industries, Inc, Kamakura, Japan
Biosci Biotechnol Biochem 56:211-4. 1992..The interferon was partially purified through Blue Sepharose, and its molecular weight was estimated to be 2.4 x 10(4). The antiviral activity was acid stable, and glycosylation was suggested...