Akio Masuda

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways
    Akio Masuda
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Immunol 169:3801-10. 2002
  2. ncbi request reprint Essential role of GATA transcriptional factors in the activation of mast cells
    Akio Masuda
    Division of Neurogenetics and Bioinformatics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 178:360-8. 2007
  3. ncbi request reprint The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells
    Akio Masuda
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 173:5564-73. 2004
  4. pmc Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome
    Yang Bian
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hum Mol Genet 18:1229-37. 2009
  5. ncbi request reprint Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells
    Norika Chiba
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Cell Physiol 213:126-36. 2007
  6. pmc AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon
    Yuan Fu
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Nucleic Acids Res 39:4396-404. 2011
  7. pmc HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA
    Mohammad Alinoor Rahman
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Sci Rep 3:2931. 2013
  8. pmc FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD
    Yusuke Fujioka
    Department of Neurology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Sci Rep 3:2388. 2013
  9. pmc Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junction
    Mikako Ito
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Ther 20:1384-92. 2012
  10. pmc JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation
    Tetsuya Matsuguchi
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    EMBO J 22:4455-64. 2003

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways
    Akio Masuda
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Immunol 169:3801-10. 2002
    ..Our findings may indicate a clue to understanding the mechanisms of how bacteria infection worsens the clinical features of asthma...
  2. ncbi request reprint Essential role of GATA transcriptional factors in the activation of mast cells
    Akio Masuda
    Division of Neurogenetics and Bioinformatics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 178:360-8. 2007
    ..Signal transduction and histone modification in the chromatin related to protein kinase Cbeta were defective in these cells. These results identify that GATA has a critical role in the activation of mast cell...
  3. ncbi request reprint The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells
    Akio Masuda
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 173:5564-73. 2004
    ..The results of the present study have shown that direct interaction between AP-1 and GATA proteins plays an important role in IL-13 transcription in mast cells...
  4. pmc Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome
    Yang Bian
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hum Mol Genet 18:1229-37. 2009
    ..These observations open the door to the discovery of novel therapies based on PTB overexpression and to detecting possible untoward effects of the overexpression...
  5. ncbi request reprint Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells
    Norika Chiba
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Cell Physiol 213:126-36. 2007
    ..Thus, ceramide appeared to down-regulate LPS-stimulated production of IL-5, IL-10, and IL-13 from mast cells by inhibiting PI3 kinase-Akt pathway in a cell type-specific manner...
  6. pmc AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon
    Yuan Fu
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Nucleic Acids Res 39:4396-404. 2011
    ..The AG-dependence of the 3'-splice site that we analyzed in disease-causing mutations at E(+1) potentially helps identify yet unrecognized splicing mutations at E(+1)...
  7. pmc HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA
    Mohammad Alinoor Rahman
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Sci Rep 3:2931. 2013
    ..HnRNP L and hnRNP LL thus antagonistically modulate PTB-mediated splicing suppression of exon P3A...
  8. pmc FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD
    Yusuke Fujioka
    Department of Neurology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Sci Rep 3:2388. 2013
    ..Thus, FUS-regulated transcriptome profiles in each cell-type may determine cellular fate in association with FUS-mediated ALS/FTLD, and identified RNA targets for FUS could be therapeutic targets for ALS/FTLD. ..
  9. pmc Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junction
    Mikako Ito
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Ther 20:1384-92. 2012
    ..We propose that the protein-anchoring strategy is potentially applicable to a broad spectrum of diseases affecting extracellular matrix molecules...
  10. pmc JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation
    Tetsuya Matsuguchi
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    EMBO J 22:4455-64. 2003
    ..7 cells, JIP3 associates MEKK-1, but not with TAK-1. Finally, JIP3 also associates with TLR2 and TLR9, but not with TLR1 or TLR6. Altogether, our data indicate the involvement of JIP3 in JNK activation in downstream signals of some TLRs...
  11. doi request reprint Mutations in the C-terminal domain of ColQ in endplate acetylcholinesterase deficiency compromise ColQ-MuSK interaction
    Tomohiko Nakata
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hum Mutat 34:997-1004. 2013
    ..We proved that the missense mutations in ColQ-CTD cause endplate AChE deficiency by compromising ColQ-MuSK interaction at the NMJ...
  12. pmc The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons
    Daiyu Honda
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    FEBS Open Bio 4:1-10. 2013
    ..The shared downstream RNA targets of TDP-43 and FUS may form a common pathway in the neurodegenerative processes of ALS/FTLD. ..
  13. doi request reprint Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophy
    Yoshihiro Yamashita
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hum Genet 57:368-74. 2012
    ..8% and a specificity of 95.6% in our data set. We propose that calculation of DV, which is unique to our analysis, is of particular importance in analyzing the exon array data...
  14. pmc hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome
    Akio Masuda
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hum Mol Genet 17:4022-35. 2008
    ..Our findings imply that the presence of the hnRNP H-binding motif close to the 3' end of an intron is an essential but underestimated splicing regulator of the downstream exon...
  15. pmc Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia
    Masaki Matsushita
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 8:e81569. 2013
    ..We propose that meclozine is a potential therapeutic agent for treating ACH and other FGFR3-related skeletal dysplasias. ..
  16. pmc Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions
    Shinsuke Ishigaki
    Department of Neurology, Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Sci Rep 2:529. 2012
    ..Our analysis revealed that FUS regulates alternative splicing events and transcriptions in a position-dependent manner...
  17. ncbi request reprint [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse]
    Kinji Ohno
    Division of Neurogenetics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:145-51. 2009
    ..We need to further pursue the molecular bases and the therapeutic strategies of defective neuromuscular transmissions, and hopefully expand our analysis to defective synapse transmissions in the central nervous system...
  18. pmc CUGBP1 and MBNL1 preferentially bind to 3' UTRs and facilitate mRNA decay
    Akio Masuda
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Sci Rep 2:209. 2012
    ..This study suggests that regulation of CUGBP1 and MBNL1 is essential for accurate control of destabilization of a broad spectrum of mRNAs as well as of alternative splicing events...
  19. pmc Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling
    Akira Takamatsu
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 9:e92699. 2014
    ..We propose that verapamil holds promise as a potent therapeutic agent for OA by upregulating FRZB and subsequently downregulating Wnt/β-catenin signaling. ..
  20. doi request reprint Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice
    Ryuichiro Yamamoto
    Department of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 8550, Japan
    J Bone Miner Metab 31:26-33. 2013
    ..Fendiline, perhexiline, and their possible derivatives are potentially applicable to clinical practice to prevent devastating heterotopic ossification in FOP...
  21. doi request reprint Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8
    Hiroshi Kaneko
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Hum Genet 130:671-83. 2011
    ..GPATCH8 is only 5.8 Mbp distant from COL1A1 and encodes a protein harboring an RNA-processing domain and a zinc finger domain, but the molecular functions have not been elucidated to date...
  22. ncbi request reprint Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice
    Tetsuya Abe
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Hepatology 40:414-23. 2004
    ..Fas-mediated hepatocyte apoptosis in cholestasis may be involved in the predominant IL-10 production by Kupffer cells...
  23. pmc Human branch point consensus sequence is yUnAy
    Kaiping Gao
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Nucleic Acids Res 36:2257-67. 2008
    ..Our analysis demonstrates that the human BPSs are more degenerative than we have expected and that the human BPSs are likely to be recognized in combination with the polypyrimidine tract and/or the other splicing cis-elements...
  24. pmc A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation
    Kenji Sugimoto
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Japan
    J Clin Invest 114:857-66. 2004
    ....
  25. pmc In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites
    Kentaro Sahashi
    Division of Neurogenetics and Bioinformatics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nucleic Acids Res 35:5995-6003. 2007
    ..8, 88.8 and 96.8% of these mutations would affect pre-mRNA splicing, respectively. We propose that the SD-Score algorithm is a practical tool to predict splicing consequences of mutations affecting the 5' splice site...
  26. doi request reprint Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease
    Yuan Fu
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurosci Lett 453:81-5. 2009
    ..Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson's disease...
  27. doi request reprint Viral vector-mediated [corrected] expression of human collagen Q in cultured cells
    Mikako Ito
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Japan
    Chem Biol Interact 175:346-8. 2008
    ..We are currently trying to achieve further higher expression levels of transgenes in cultured cells to make the current strategy applicable to an animal model...
  28. ncbi request reprint Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling
    Tipayaratn Musikacharoen
    Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Blood 105:711-20. 2005
    ..Thus, IL-15 induces chromatin remodeling of the IL12RB1 gene promoter, increasing IL12RB1 mRNA expression in synergy with IFN-gamma through the recruitment of PU.1 and IRF3...
  29. pmc Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities
    Masatoshi Ichihara
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai 487 8501, Japan
    Nucleic Acids Res 35:e123. 2007
    ..We assayed 86 siRNAs in HEK293 cells using pSELL, and validated applicability of i-Score and the whole DeltaG value in designing siRNAs...