Research Topics
Genomes and Genes | Akio MasudaSummaryAffiliation: Nagoya University Country: Japan Publications
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Publications
Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathwaysAkio Masuda
Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
J Immunol 169:3801-10. 2002..Our findings may indicate a clue to understanding the mechanisms of how bacteria infection worsens the clinical features of asthma...- Essential role of GATA transcriptional factors in the activation of mast cellsAkio Masuda
Division of Neurogenetics and Bioinformatics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Immunol 178:360-8. 2007..Signal transduction and histone modification in the chromatin related to protein kinase Cbeta were defective in these cells. These results identify that GATA has a critical role in the activation of mast cell... - The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cellsAkio Masuda
Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Immunol 173:5564-73. 2004..The results of the present study have shown that direct interaction between AP-1 and GATA proteins plays an important role in IL-13 transcription in mast cells... 
Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndromeYang Bian
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
Hum Mol Genet 18:1229-37. 2009..These observations open the door to the discovery of novel therapies based on PTB overexpression and to detecting possible untoward effects of the overexpression...- Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cellsNorika Chiba
Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Cell Physiol 213:126-36. 2007..Thus, ceramide appeared to down-regulate LPS-stimulated production of IL-5, IL-10, and IL-13 from mast cells by inhibiting PI3 kinase-Akt pathway in a cell type-specific manner... - AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exonYuan Fu
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
Nucleic Acids Res 39:4396-404. 2011..The AG-dependence of the 3'-splice site that we analyzed in disease-causing mutations at E(+1) potentially helps identify yet unrecognized splicing mutations at E(+1)... - JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activationTetsuya Matsuguchi
Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
EMBO J 22:4455-64. 2003..7 cells, JIP3 associates MEKK-1, but not with TAK-1. Finally, JIP3 also associates with TLR2 and TLR9, but not with TLR1 or TLR6. Altogether, our data indicate the involvement of JIP3 in JNK activation in downstream signals of some TLRs... 
Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophyYoshihiro Yamashita
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Hum Genet 57:368-74. 2012..8% and a specificity of 95.6% in our data set. We propose that calculation of DV, which is unique to our analysis, is of particular importance in analyzing the exon array data...- hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndromeAkio Masuda
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
Hum Mol Genet 17:4022-35. 2008..Our findings imply that the presence of the hnRNP H-binding motif close to the 3' end of an intron is an essential but underestimated splicing regulator of the downstream exon... - [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse]Kinji Ohno
Division of Neurogenetics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 29:145-51. 2009..We need to further pursue the molecular bases and the therapeutic strategies of defective neuromuscular transmissions, and hopefully expand our analysis to defective synapse transmissions in the central nervous system... - Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junctionMikako Ito
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
Mol Ther 20:1384-92. 2012..We propose that the protein-anchoring strategy is potentially applicable to a broad spectrum of diseases affecting extracellular matrix molecules... - Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8Hiroshi Kaneko
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
Hum Genet 130:671-83. 2011..GPATCH8 is only 5.8 Mbp distant from COL1A1 and encodes a protein harboring an RNA-processing domain and a zinc finger domain, but the molecular functions have not been elucidated to date... - Human branch point consensus sequence is yUnAyKaiping Gao
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
Nucleic Acids Res 36:2257-67. 2008..Our analysis demonstrates that the human BPSs are more degenerative than we have expected and that the human BPSs are likely to be recognized in combination with the polypyrimidine tract and/or the other splicing cis-elements... - A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiationKenji Sugimoto
Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Japan
J Clin Invest 114:857-66. 2004.... - Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated miceTetsuya Abe
Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
Hepatology 40:414-23. 2004..Fas-mediated hepatocyte apoptosis in cholestasis may be involved in the predominant IL-10 production by Kupffer cells... - Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptionsShinsuke Ishigaki
Department of Neurology, Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
Sci Rep 2:529. 2012..Our analysis revealed that FUS regulates alternative splicing events and transcriptions in a position-dependent manner... - Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's diseaseYuan Fu
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
Neurosci Lett 453:81-5. 2009..Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson's disease... 
In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sitesKentaro Sahashi
Division of Neurogenetics and Bioinformatics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
Nucleic Acids Res 35:5995-6003. 2007..8, 88.8 and 96.8% of these mutations would affect pre-mRNA splicing, respectively. We propose that the SD-Score algorithm is a practical tool to predict splicing consequences of mutations affecting the 5' splice site...- Viral vector-mediated [corrected] expression of human collagen Q in cultured cellsMikako Ito
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Japan
Chem Biol Interact 175:346-8. 2008..We are currently trying to achieve further higher expression levels of transgenes in cultured cells to make the current strategy applicable to an animal model... - Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodelingTipayaratn Musikacharoen
Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Blood 105:711-20. 2005..Thus, IL-15 induces chromatin remodeling of the IL12RB1 gene promoter, increasing IL12RB1 mRNA expression in synergy with IFN-gamma through the recruitment of PU.1 and IRF3... - Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activitiesMasatoshi Ichihara
Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai 487 8501, Japan
Nucleic Acids Res 35:e123. 2007..We assayed 86 siRNAs in HEK293 cells using pSELL, and validated applicability of i-Score and the whole DeltaG value in designing siRNAs...