N Kurosawa

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi Comparative analysis of the genomic structures and promoter activities of mouse Siaalpha2,3Galbeta1,3GalNAc GalNAcalpha2, 6-sialyltransferase genes (ST6GalNAc III and IV): characterization of their Sp1 binding sites
    S Takashima
    Molecular Glycobiology, Frontier Research Program, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Biochem 127:399-409. 2000
  2. ncbi Midkine binds specifically to sulfatide the role of sulfatide in cell attachment to midkine-coated surfaces
    N Kurosawa
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Eur J Biochem 267:344-51. 2000
  3. ncbi Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164
    N Kurosawa
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Eur J Biochem 265:466-72. 1999
  4. ncbi Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth
    N Kurosawa
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Japan
    Glycoconj J 18:499-507. 2001
  5. ncbi Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase
    K Uchimura
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya 466, Japan
    J Biol Chem 273:22577-83. 1998
  6. ncbi Functional analysis of promoter activity of murine beta-1,6-N-acetylglucosaminyltransferase
    G Y Chen
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
    Gene 275:253-9. 2001
  7. ncbi Genomic organization and promoter activity of embigin, a member of the immunoglobulin superfamily
    H Tachikui
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Gene 240:325-32. 1999
  8. ncbi Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities
    K Uchimura
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Biochem Biophys Res Commun 274:291-6. 2000
  9. ncbi Colocalization of neuropilin-1 and Flk-1 in retinal neovascularization in a mouse model of retinopathy
    H Ishihama
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Invest Ophthalmol Vis Sci 42:1172-8. 2001
  10. ncbi A novel variant form of murine beta-1, 6-N-acetylglucosaminyltransferase forming branches in poly-N-acetyllactosamines
    G Y Chen
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Glycobiology 10:1001-11. 2000

Collaborators

Detail Information

Publications18

  1. ncbi Comparative analysis of the genomic structures and promoter activities of mouse Siaalpha2,3Galbeta1,3GalNAc GalNAcalpha2, 6-sialyltransferase genes (ST6GalNAc III and IV): characterization of their Sp1 binding sites
    S Takashima
    Molecular Glycobiology, Frontier Research Program, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Biochem 127:399-409. 2000
    ....
  2. ncbi Midkine binds specifically to sulfatide the role of sulfatide in cell attachment to midkine-coated surfaces
    N Kurosawa
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Eur J Biochem 267:344-51. 2000
    ..These results indicate that midkine binds to sulfatide under physiological conditions and the midkine-sulfatide interaction may be important in controlling cell attachment...
  3. ncbi Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164
    N Kurosawa
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Eur J Biochem 265:466-72. 1999
    ..That the promoter resembles that of house-keeping genes is consistent with the broad expression of mouse MGC-24 mRNA...
  4. ncbi Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth
    N Kurosawa
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Japan
    Glycoconj J 18:499-507. 2001
    ..In addition, we observed different localization of epitope-tagged glypican-2 and syndecan-3 on the surface of N2a cells; the result suggested that they may play different roles in MK-mediated neural function...
  5. ncbi Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase
    K Uchimura
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya 466, Japan
    J Biol Chem 273:22577-83. 1998
    ..The products of the sulfotransferase probably include glycoconjugates with intercellular recognition signals; one candidate of such a glycoconjugate is an L-selectin ligand...
  6. ncbi Functional analysis of promoter activity of murine beta-1,6-N-acetylglucosaminyltransferase
    G Y Chen
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
    Gene 275:253-9. 2001
    ..Mutation of the single GT box in IGnT A and two GT boxes in IGnT B caused marked reduction of the promoter activity. These findings provided strong evidence that the GT boxes play crucial roles in transcriptional regulation of the genes...
  7. ncbi Genomic organization and promoter activity of embigin, a member of the immunoglobulin superfamily
    H Tachikui
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Gene 240:325-32. 1999
    ..Deletion analysis of the 3.5kb DNA fragment revealed that the region between -125 to +1, containing a single Sp1 binding site, is essential for transcription of the embigin gene...
  8. ncbi Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities
    K Uchimura
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Biochem Biophys Res Commun 274:291-6. 2000
    ..The distribution and the specificity of GlcNAc6ST are different from those of GlcNAc6STs identified previously...
  9. ncbi Colocalization of neuropilin-1 and Flk-1 in retinal neovascularization in a mouse model of retinopathy
    H Ishihama
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Invest Ophthalmol Vis Sci 42:1172-8. 2001
    ..To investigate the mechanisms of the development of retinal neovascularization, the localizations of vascular endothelial (VEGF) receptors Flk-1 and neuropilin (NP)-1 mRNAs were examined...
  10. ncbi A novel variant form of murine beta-1, 6-N-acetylglucosaminyltransferase forming branches in poly-N-acetyllactosamines
    G Y Chen
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Glycobiology 10:1001-11. 2000
    ..Although addition of sialic acid to the terminal galactosyl residue did not abolish the acceptor activity, alpha2-6 sialylation was a preferred one as compared to alpha2-3 sialylation...
  11. ncbi Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping
    K Uchimura
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Glycobiology 8:489-96. 1998
    ..Fluorescence in situ hybridization analysis revealed the gene is located in mouse chromosome 9...
  12. ncbi Progesterone stimulates the expression of aminopeptidase A/angiotensinase in human choriocarcinoma cells
    Y Katsumata
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Placenta 22:831-6. 2001
    ..These findings may serve as a useful model to study the effects of progesterone on angiotensin II metabolism in placenta, although the physiological validity of these studies remains to be clarified...
  13. ncbi Polysialic acid synthase (ST8Sia II/STX) mRNA expression in the developing mouse central nervous system
    N Kurosawa
    Molecular Glycobiology, Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Wako Shi, Saitama, Japan
    J Neurochem 69:494-503. 1997
    ..The regional and transient expression of ST8Sia II mRNA coincides with that of PSA, suggesting that ST8Sia II is closely involved in the biosynthesis and expression of PSA in the developing mouse CNS...
  14. ncbi Molecular cloning and genomic analysis of mouse GalNAc alpha2, 6-sialyltransferase (ST6GalNAc I)
    N Kurosawa
    Molecular Glycobiology, Frontier Research Program, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Biochem 127:845-54. 2000
    ..Analysis of the 5'-RACE PCR products suggested that the mouse ST6GalNAc I gene expression is regulated by these two promoters in tissue-specific manners...
  15. ncbi Two step single primer mediated polymerase chain reaction. Application to cloning of putative mouse, beta-galactoside alpha 2,6-sialyltransferase cDNA
    T Hamamoto
    Glyco Molecular Biology, Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Bioorg Med Chem 1:141-5. 1993
    ..The result showed that the specificity and consequently applicability of the single primer mediated PCR for amplifying a particular DNA fragment beyond known sequence region was remarkably improved by the successive 2nd reaction...
  16. ncbi Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens
    Y Ikehara
    Division of Cell Biology, Institute of Life Science, Soka University, 1 236 Tangi cho, Hachioji, Tokyo 192 8577, Japan
    Glycobiology 9:1213-24. 1999
    ..Thus, we determined that the long-form cDNA of the human ST6GalNAc I gene encodes the probable candidate for the human sTn synthase(s)...
  17. ncbi Molecular cloning and genomic analysis of mouse Galbeta1, 3GalNAc-specific GalNAc alpha2,6-sialyltransferase
    N Kurosawa
    Department of Molecular Glycobiology, Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 01, Japan
    J Biol Chem 271:15109-16. 1996
    ..Transient transfection experiments involving luciferase reporter genes demonstrated promoter activity in NIH3T3 cells...
  18. ncbi Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity
    T Nakamura
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    J Biol Chem 267:18924-8. 1992
    ..These results suggest that signal transduction of activin employs a novel pathway via a new class of cellular receptor in EC P19 cells...