S Kunishima

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Presence of Propionibacterium acnes in blood components
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Minamiyamaguchi, Seto, Japan
    Transfusion 41:1126-9. 2001
  2. ncbi request reprint Novel nonsense mutation in the platelet glycoprotein Ibbeta gene associated with Bernard-Soulier syndrome
    Shinji Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Am J Hematol 71:279-84. 2002
  3. ncbi request reprint Expression of low-frequency Ala108Pro substitution in the platelet glycoprotein Ibbeta gene
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Eur J Immunogenet 30:159-61. 2003
  4. ncbi request reprint Genetic abnormalities of Bernard-Soulier syndrome
    Shinji Kunishima
    Int J Hematol 76:319-27. 2002
  5. ncbi request reprint Homozygous Pro74-->Arg mutation in the platelet glycoprotein Ibbeta gene associated with Bernard-Soulier syndrome
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Thromb Haemost 84:112-7. 2000
  6. ncbi request reprint Platelet glycoprotein (GP) V polymorphisms in Japanese
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto
    Tissue Antigens 54:285-7. 1999
  7. ncbi request reprint Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome
    S Kunishima
    Japanese Red Cross Aichi Blood Centre, Seto, Aichi, Japan
    Br J Haematol 107:539-45. 1999
  8. ncbi request reprint Novel heterozygous missense mutation in the platelet glycoprotein Ib beta gene associated with isolated giant platelet disorder
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Am J Hematol 68:249-55. 2001
  9. ncbi request reprint A new polymorphism in the HLA-F gene (67Ala[GCC] to Ala[GCG])
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Immunogenetics 49:147-8. 1999
  10. doi request reprint Identification and characterization of the first large deletion of the MYH9 gene associated with MYH9 disorders
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Eur J Haematol 80:540-4. 2008

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Presence of Propionibacterium acnes in blood components
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Minamiyamaguchi, Seto, Japan
    Transfusion 41:1126-9. 2001
    ..18%), all of which were RBC concentrates, were contaminated with bacteria. Nine isolates were Propionibacterium acnes and one was Staphylococcus capitis...
  2. ncbi request reprint Novel nonsense mutation in the platelet glycoprotein Ibbeta gene associated with Bernard-Soulier syndrome
    Shinji Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Am J Hematol 71:279-84. 2002
    ....
  3. ncbi request reprint Expression of low-frequency Ala108Pro substitution in the platelet glycoprotein Ibbeta gene
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Eur J Immunogenet 30:159-61. 2003
    ..In vitro expression studies showed surface expression of the GPIbbeta Pro108 variant, suggesting the possibility of the involvement of the substitution as an alloantigen...
  4. ncbi request reprint Genetic abnormalities of Bernard-Soulier syndrome
    Shinji Kunishima
    Int J Hematol 76:319-27. 2002
    ..In this review, we summarize recent advances in the molecular basis of BSS with special emphasis on giant platelets and the genetic characteristics of Japanese BSS...
  5. ncbi request reprint Homozygous Pro74-->Arg mutation in the platelet glycoprotein Ibbeta gene associated with Bernard-Soulier syndrome
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Thromb Haemost 84:112-7. 2000
    ..The mutant GPIbbeta was normally transcribed. Transient transfection studies confirmed that mutant GPIbbeta impairs surface expression of GPIb/IX, showing that the mutation is responsible for a BSS phenotype observed in the patient...
  6. ncbi request reprint Platelet glycoprotein (GP) V polymorphisms in Japanese
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto
    Tissue Antigens 54:285-7. 1999
    ..Flow cytometric analysis showed that the 341Arg variant is expressed normally on the platelet membranes, suggesting the possibility of the involvement of the 341Gly/Arg polymorphism as a platelet alloantigen...
  7. ncbi request reprint Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome
    S Kunishima
    Japanese Red Cross Aichi Blood Centre, Seto, Aichi, Japan
    Br J Haematol 107:539-45. 1999
    ..Transient transfection studies confirmed that mutant GPIX was not expressed on the transfected cells, showing that the mutation was responsible for the BSS phenotype observed in the patient...
  8. ncbi request reprint Novel heterozygous missense mutation in the platelet glycoprotein Ib beta gene associated with isolated giant platelet disorder
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Am J Hematol 68:249-55. 2001
    ....
  9. ncbi request reprint A new polymorphism in the HLA-F gene (67Ala[GCC] to Ala[GCG])
    S Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Immunogenetics 49:147-8. 1999
  10. doi request reprint Identification and characterization of the first large deletion of the MYH9 gene associated with MYH9 disorders
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Eur J Haematol 80:540-4. 2008
    ..Immunoblot analysis showed a small, abnormal protein in neutrophils but not in platelets. This is the first report of a large deletion of the MYH9 gene leading to the development of MYH9 disorders...
  11. ncbi request reprint Novel heterozygous missense mutation in the second leucine rich repeat of GPIbalpha affects GPIb/IX/V expression and results in macrothrombocytopenia in a patient initially misdiagnosed with idiopathic thrombocytopenic purpura
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Eur J Haematol 76:348-55. 2006
    ..These findings suggest that null expression of the mutant GPIbalpha causes decreased density of the complex and results in macrothrombocytopenia...
  12. ncbi request reprint Molecular genetic analysis of a variant Bernard-Soulier syndrome due to compound heterozygosity for two novel glycoprotein Ibbeta mutations
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Eur J Haematol 77:501-12. 2006
    ..These results suggest that despite disruption of the disulfide linkage between GPIbalpha and GPIbbeta, GPIb/IX is formed, but its stability may be impaired, resulting in low levels of the complex on the platelet membranes...
  13. ncbi request reprint First Turkish case of Bernard-Soulier syndrome associated with GPIX N45S
    Necati Da─čistan
    Department of Hematology, Golcuk Military Hospital, Golcuk, Turkey
    Acta Haematol 118:146-8. 2007
    ..This is the first non-Caucasian Turkish BSS case due to GPIX N45S and is likely the result of a recurrent mutational event...
  14. ncbi request reprint Bernard-Soulier syndrome due to GPIX W127X mutation in Japan is frequently misdiagnosed as idiopathic thrombocytopenic purpura
    Shinji Kunishima
    Int J Hematol 83:366-7. 2006
  15. ncbi request reprint Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice
    Tadashi Matsushita
    Department of Hematology, Nagoya University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 325:1163-71. 2004
    ..Such observation may parallel the diverse expression of Alport's manifestations of human individuals with MYH9 disorders and suggest the limited requirement of the gene for maintenance and function of specific organs...
  16. doi request reprint Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Blood 111:3015-23. 2008
    ..We show the differential expression of mutant NMMHC-IIA and postulate that cell-specific regulation mechanisms function in MYH9 disorders...
  17. ncbi request reprint Haematological characteristics of MYH9 disorders due to MYH9 R702 mutations
    Shinji Kunishima
    Department of Haemostasis and Thrombosis, Clinical Research Centre, National Hospital Organization Nagoya Medical Centre, Nagoya, Japan
    Eur J Haematol 78:220-6. 2007
    ..The aim of our study was to determine the haematological characteristics of MYH9 disorders as a result of R702 mutations to aid in making a proper diagnosis...
  18. doi request reprint Characterization of a patient with atypical amegakaryocytic thrombocytopenia
    Sachiko Kanaji
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    Eur J Haematol 80:361-4. 2008
    ..To our knowledge, this is the first report that describes a case of amegakaryocytic thrombocytopenia that is not caused by a mutation in MPL and demonstrates the severe impairment of GPVI expression on platelets...
  19. ncbi request reprint Historical hematology: May-Hegglin anomaly
    Hidehiko Saito
    Nagoya Central Hospital, Nagoya, Japan
    Am J Hematol 83:304-6. 2008
    ..Current interest is centered upon the mechanisms by which a single mutation causes a variety of phenotypes...
  20. ncbi request reprint Identification of a novel MYH9 mutation in a patient with May-Hegglin anomaly
    Keisuke Otsubo
    Pediatr Blood Cancer 47:968-9. 2006
  21. ncbi request reprint Further characterization of anti-platelet monoclonal antibody HPL5 as anti-glycoprotein V antibody
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya University School of Health Sciences, Nagoya, Japan
    Acta Haematol 115:128-30. 2006
  22. ncbi request reprint Congenital macrothrombocytopenias
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Blood Rev 20:111-21. 2006
    ..This review summarizes the current knowledge on the clinical and laboratory features of common congenital macrothrombocytopenias and discusses how that knowledge aids in making a proper diagnosis...
  23. ncbi request reprint First description of somatic mosaicism in MYH9 disorders
    Shinji Kunishima
    Department of Haemostasis and Thrombosis, Clinical Research Centre, National Hospital Organization Nagoya Medical Centre, Nagoya, Japan
    Br J Haematol 128:360-5. 2005
    ..Mosaicism might account for some de novo mutations in MYH9 disorders...
  24. ncbi request reprint Detection of unique neutrophil non-muscle myosin heavy chain-A localization by immunofluorescence analysis in MYH9 disorder presented with macrothrombocytopenia without leukocyte inclusions and deafness
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan
    Eur J Haematol 74:1-5. 2005
    ..These results further support the usefulness of immunofluorescence analysis in differential diagnosis of MYH9 disorders...
  25. ncbi request reprint A unique immunofluorescence method promotes accurate diagnosis in MYH9 disorders: a case report
    Miyako Yoshinari
    Department of Pediatric Oncology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Pediatr Hematol Oncol 26:579-83. 2004
    ..MYH9 disorders may be much more common than previously realized if accurately diagnosed...
  26. ncbi request reprint [May-Hegglin anomaly--from genome research to clinical laboratory]
    Shinji Kunishima
    Japanese Red Cross Aichi Blood Center, Seto 489 8555
    Rinsho Byori 51:898-904. 2003
    ..Immunofluorescence analysis of neutrophil NMMHCA is useful as a novel screening test for the differential diagnosis of macrothrombocytopenia and clear hematopathological classification of MYH9 disorders...
  27. ncbi request reprint Immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A in MYH9 disorders: association of subcellular localization with MYH9 mutations
    Shinji Kunishima
    Japanese Red Cross Aichi Blood Center, Seto, Japan
    Lab Invest 83:115-22. 2003
    ..Immunofluorescence analysis of neutrophil NMMHCA is useful as a screening test for the clear hematopathologic classification of MYH9 disorders...
  28. doi request reprint Accumulation of MYH9 mRNA at leukocyte inclusion bodies in MYH9 disorders
    Shinji Kunishima
    Eur J Haematol 81:325-6. 2008