T Kondo

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Exercise-induced nausea is exaggerated by eating
    T Kondo
    Department of Human Nutrition, Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan
    Appetite 36:119-25. 2001
  2. pmc Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria
    H Iwasaki
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    EMBO J 18:1137-45. 1999
  3. pmc Nucleotide binding and autophosphorylation of the clock protein KaiC as a circadian timing process of cyanobacteria
    T Nishiwaki
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 97:495-9. 2000
  4. ncbi request reprint Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC
    Y Taniguchi
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    FEBS Lett 496:86-90. 2001
  5. ncbi request reprint A kaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria
    H Iwasaki
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Cell 101:223-33. 2000
  6. pmc A period-extender gene, pex, that extends the period of the circadian clock in the cyanobacterium Synechococcus sp. strain PCC 7942
    S Kutsuna
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    J Bacteriol 180:2167-74. 1998
  7. pmc Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway
    T Kondo
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
    Mol Cell Biol 19:1136-43. 1999
  8. ncbi request reprint Colonic fermentation after ingestion of fructose-containing sports drink
    T Mitsui
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan
    J Sports Med Phys Fitness 41:121-3. 2001
  9. ncbi request reprint Prolongation of activation-recovery interval over a preexcited region before and after catheter ablation in patients with Wolff-Parkinson-White syndrome
    Y Inden
    First Department of Internal Medicine, University of Nagoya School of Medicine, Japan
    J Cardiovasc Electrophysiol 12:939-45. 2001
  10. ncbi request reprint A prospective study of body size and colon cancer mortality in Japan: The JACC Study
    K Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Int J Obes Relat Metab Disord 28:551-8. 2004

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Exercise-induced nausea is exaggerated by eating
    T Kondo
    Department of Human Nutrition, Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan
    Appetite 36:119-25. 2001
    ..Training did not decrease exercise-induced nausea. In conclusion, exercise causes nausea, the severity of which is related to exercise intensity and food intake, but not sex differences nor physical training...
  2. pmc Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria
    H Iwasaki
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    EMBO J 18:1137-45. 1999
    ..Thus, direct protein-protein association among the Kai proteins may be a critical process in the generation of circadian rhythms in cyanobacteria...
  3. pmc Nucleotide binding and autophosphorylation of the clock protein KaiC as a circadian timing process of cyanobacteria
    T Nishiwaki
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 97:495-9. 2000
    ..Moreover, KaiC can be autophosphorylated in vitro. These results suggest that the nucleotide-binding activity of KaiC plays important roles in the generation of circadian oscillation in cyanobacteria...
  4. ncbi request reprint Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC
    Y Taniguchi
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    FEBS Lett 496:86-90. 2001
    ..Thus, interaction between KaiA and KaiC through C(KABD1) and C(KABD2) is likely important for circadian timing in the cyanobacterium...
  5. ncbi request reprint A kaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria
    H Iwasaki
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Cell 101:223-33. 2000
    ..Thus, SasA is a close associate of the cyanobacterial clock that is necessary to sustain robust circadian rhythms...
  6. pmc A period-extender gene, pex, that extends the period of the circadian clock in the cyanobacterium Synechococcus sp. strain PCC 7942
    S Kutsuna
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    J Bacteriol 180:2167-74. 1998
    ..In various clock mutants examined, overexpression caused arrhythmicity. Thus, Pex is likely to function as a modifier of the circadian clock in Synechococcus...
  7. pmc Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway
    T Kondo
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
    Mol Cell Biol 19:1136-43. 1999
    ..Taken together, our results suggest that Rad17, Mec3, and Ddc1 form a complex which functions downstream of Rad24 in the DNA damage checkpoint pathway...
  8. ncbi request reprint Colonic fermentation after ingestion of fructose-containing sports drink
    T Mitsui
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan
    J Sports Med Phys Fitness 41:121-3. 2001
    ..However, a number of studies of abdominal complaints have indicated fructose malabsorption. In the present study, we examined colonic fermentation of a fructose-containing sports drink...
  9. ncbi request reprint Prolongation of activation-recovery interval over a preexcited region before and after catheter ablation in patients with Wolff-Parkinson-White syndrome
    Y Inden
    First Department of Internal Medicine, University of Nagoya School of Medicine, Japan
    J Cardiovasc Electrophysiol 12:939-45. 2001
    ..However, no report has provided direct evidence for prolongation of action potential duration (APD) over a preexcited region before and after ablation...
  10. ncbi request reprint A prospective study of body size and colon cancer mortality in Japan: The JACC Study
    K Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Int J Obes Relat Metab Disord 28:551-8. 2004
    ..To determine whether body size measurements are risk factors for colon cancer death among the Japanese...
  11. ncbi request reprint The circadian clock of cyanobacteria
    T Kondo
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya, Japan
    Bioessays 22:10-5. 2000
    ..BioEssays 22:10-15, 2000...
  12. ncbi request reprint The accuracy of long-term recall of past body weight in Japanese adult men
    K Tamakoshi
    Department of Public Health Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Japan
    Int J Obes Relat Metab Disord 27:247-52. 2003
    ..To examine the influences of recall period, current body weight, weight gain and loss, and weight variability on the accuracy of long-term recall of past weight...
  13. ncbi request reprint Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men
    K Tamakoshi
    Department of Public Health Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Obes Relat Metab Disord 27:1059-65. 2003
    ..To elucidate the effect of long-term weight variability on C-reactive protein (CRP) levels...
  14. ncbi request reprint Spectroscopic and electrochemical studies on structural change of plastocyanin and its tyrosine 83 mutants induced by interaction with lysine peptides
    S Hirota
    Department of Chemistry, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Japan
    Biochemistry 39:6357-64. 2000
    ....
  15. ncbi request reprint Contribution of each caffeoyl residue of the pigment molecule of gentiodelphin to blue color development
    K Yoshida
    School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
    Phytochemistry 54:85-92. 2000
    ..Additionally, the acyl residue in the B-ring contributed more to blue color development than that in the A-ring...
  16. pmc Chloride transport in microperfused interlobular ducts isolated from guinea-pig pancreas
    H Ishiguro
    Internal Medicine II and Human Nutrition, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Physiol 539:175-89. 2002
    ..The resulting lack of competition from intracellular Cl- may therefore favour HCO3- secretion via anion conductances in the luminal membrane, possibly CFTR...
  17. ncbi request reprint The current state and problems of circadian clock studies in cyanobacteria
    H Iwasaki
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Japan
    Plant Cell Physiol 41:1013-20. 2000
    ..Finally, we will document some current problems in the studies on the cyanobacterial circadian clock...
  18. ncbi request reprint Association between weight fluctuation and fasting insulin concentration in Japanese men
    H Yatsuya
    Department of Public Health Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Japan
    Int J Obes Relat Metab Disord 27:478-83. 2003
    ..To investigate whether long-term weight fluctuation is associated with the fasting serum insulin concentration...
  19. pmc Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study
    H Yatsuya
    Department of Public Health Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Br J Cancer 91:929-34. 2004
    ..pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone...
  20. ncbi request reprint Molecular forms of serum pancreatic stone protein in acute pancreatitis
    Y Nakae
    Second Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Int J Pancreatol 25:17-21. 1999
    ..Elevation of serum pancreatic stone protein-(PSP) S1 suggests activation of trypsinogen in the pancreas. This information would prompt the start of intensive treatment and may improve prognosis of acute pancreatitis (AP)...
  21. ncbi request reprint Decrease in risk of lung cancer death in males after smoking cessation by age at quitting: findings from the JACC study
    K Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 92:821-8. 2001
    ..The absolute rate, however, substantially decreased after smoking cessation even in those who quit at ages 60 - 69, reflecting the high mortality rate among continuing smokers in the elderly...
  22. pmc Membrane potential and bicarbonate secretion in isolated interlobular ducts from guinea-pig pancreas
    H Ishiguro
    Internal Medicine II, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    J Gen Physiol 120:617-28. 2002
    ..Our calculations indicate that the electrodiffusive efflux of HCO(3)(-) to the lumen via CFTR, driven by this gradient, would be sufficient to fully account for the observed secretory flux of HCO(3)(-)...
  23. ncbi request reprint Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Eur J Biochem 251:729-33. 1998
    ..We found that amino acids in the region of residues 78-258 of the lamin B1 rod domain directly bound with LAP2. The data suggest that LAP2 may modulate the assembly of nuclear lamins...
  24. doi request reprint Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes
    M Naito
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Epidemiol Infect 138:512-8. 2010
    ..016). Our findings suggested that circulating IL-8 levels were associated with H. pylori infection. The effect of H. pylori infection on plasma IL-8 levels was not clearly modified by the IL-8 T-251A polymorphism...
  25. ncbi request reprint Characterization of the chromatin binding activity of lamina-associated polypeptide (LAP) 2
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Biochem Biophys Res Commun 238:240-6. 1997
    ....
  26. ncbi request reprint The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state
    K Tamakoshi
    Department of Public Health Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Japan
    Int J Obes Relat Metab Disord 27:443-9. 2003
    ..0 mg/dl) measured by high-sensitive CRP assay with the metabolic syndrome (MS)...
  27. ncbi request reprint Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria
    M Ishiura
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya, 464 8602, Japan
    Science 281:1519-23. 1998
    ..Temporal kaiC overexpression reset the phase of the rhythms. Thus, a negative feedback control of kaiC expression by KaiC generates a circadian oscillation in cyanobacteria, and KaiA sustains the oscillation by enhancing kaiC expression...
  28. ncbi request reprint Trends in the mortality (1950-1997) and incidence (1975-1993) of malignant ovarian neoplasm among Japanese women: analyses by age, time, and birth cohort
    K Tamakoshi
    Department of Public Health, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Gynecol Oncol 83:64-71. 2001
    ..The purpose of this study was to explore epidemiological features of malignant ovarian neoplasm in Japan...
  29. ncbi request reprint A cyanobacterial circadian clock based on the Kai oscillator
    T Kondo
    Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    Cold Spring Harb Symp Quant Biol 72:47-55. 2007
    ..From these analyses, we have proposed a circadian program consisting of the three proteins that keeps biological time in a living cell...
  30. ncbi request reprint Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
    T Kondo
    Division of Biological Science, Graduate School of Science, Nagoya University, CREST, Japan Science and Technology Corporation, Chikusa ku, Nagoya 464 0814, Japan
    Science 294:867-70. 2001
    ..Thus, Mec1 and Ddc1 are recruited independently to sites of DNA damage, suggesting the existence of two separate mechanisms involved in recognition of DNA damage...
  31. ncbi request reprint Small bowel bacterial overgrowth and rice malabsorption in healthy and physically disabled older adults
    T Mitsui
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Furocho, Chikusaku, Japan
    J Hum Nutr Diet 16:119-22. 2003
    ..To determine whether there are differences in small bowel bacterial overgrowth (SBBO) and rice digestion between healthy and disabled older adults and to estimate the influence of physical activity on these nutritional statuses...
  32. pmc Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
    T Wakayama
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
    Mol Cell Biol 21:755-64. 2001
    ..Thus, Pie1 is structurally and functionally related to Rad26 and interacts with Mec1 to control checkpoints and cell proliferation...
  33. pmc Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae
    T Naiki
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
    Mol Cell Biol 20:5888-96. 2000
    ....
  34. pmc Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway
    T Naiki
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
    Mol Cell Biol 21:5838-45. 2001
    ..Our results suggest that Chl12 forms a novel RFC-related complex and functions redundantly with Rad24 in the DNA replication block checkpoint...
  35. ncbi request reprint Ventricular activation and recovery measured in electrocardiographic limb leads correlate with measurements from specific areas in body surface mapping
    T Sawada
    First Department of Internal Medicine, Nagoya University, School of Medicine, Japan
    Europace 4:401-10. 2002
    ..The aim of this study was to examine whether temporal parameters from limb leads represent activation and repolarization of a particular part of the body surface...
  36. doi request reprint Female reproductive factors and the risk of gastric cancer in a large-scale population-based cohort study in Japan (JPHC study)
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:345-53. 2008
    ..Although early estrogen exposure may have some protective effect, female reproductive factors may have no substantial influence on gastric cancer development...
  37. ncbi request reprint Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I
    Junko Ishihara
    Department of Public Health Medicine, University of Tsukuba, Ibaraki, Japan
    J Am Coll Nutr 27:127-36. 2008
    ..To investigate the association of dietary folate, vitamin B(6) (VB(6)) and vitamin B(12) (VB(12)) with the risk of coronary heart disease among middle-aged persons...
  38. doi request reprint Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo ku 104 0045, Tokyo, Japan
    Carcinogenesis 29:1042-8. 2008
    ..Our findings suggest that those who have very low plasma levels of alpha-carotene and beta-carotene are at a higher risk of gastric cancer...
  39. ncbi request reprint Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based prospective study
    Tetsuya Otani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Causes Control 19:67-74. 2008
    ..We investigated the association between plasma folate and the risk of colorectal cancer in a nested case-control study...
  40. doi request reprint Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 168:391-403. 2008
    ..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...
  41. pmc A nested case-control study of stomach cancer in relation to green tea consumption in Japan
    Y Hoshiyama
    Department of Public Health, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    Br J Cancer 90:135-8. 2004
    ..6-2.8), 1.0 (95% CI: 0.5-1.9), 0.8 (95% CI: 0.4-1.6), and 1.2 (95% CI: 0.6-2.5), respectively (P for trend=0.899). We found no inverse association between green tea consumption and the risk of stomach cancer...
  42. ncbi request reprint Parental longevity and mortality amongst Japanese men and women: the JACC Study
    A Ikeda
    Department of Public Health Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Ibaraki, Japan
    J Intern Med 259:285-95. 2006
    ..To examine whether the risk of mortality varies according to parents' age at death...
  43. ncbi request reprint Symptoms in relation to chemicals and dampness in newly built dwellings
    Y Saijo
    Department of Public Heath, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    Int Arch Occup Environ Health 77:461-70. 2004
    ..The aim of this study was to clarify whether symptoms in residents living in newly built dwellings were related to chemicals and dampness...
  44. ncbi request reprint Familial aggregation and coaggregation of history of hypertension and stroke
    T Kondo
    Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan
    J Hum Hypertens 19:119-25. 2005
    ....
  45. pmc Genetic evidence for CFTR dysfunction in Japanese: background for chronic pancreatitis
    K Fujiki
    J Med Genet 41:e55. 2004
  46. ncbi request reprint Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway
    S Fukuda
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Cell Death Differ 11:196-202. 2004
    ..Together, these results reveal a novel molecular function of OLIG2 on the astrocyte development. Cell Death and Differentiation (2004) 11, 196-202. doi:10.1038/sj.cdd.4401332 Published online 24 October 2003..
  47. ncbi request reprint A polymorphism in the CYP17 gene relates to the risk of recurrent pregnancy loss
    F Sata
    Department of Public Heath, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Hum Reprod 9:725-8. 2003
    ..14; 95% CI, 1.14-4.01; A2/A2 genotype: OR, 2.50; 95% CI, 1.16-5.41; P trend, 0.015]. These results suggest that possession of the A2 variant of CYP17 may predispose to an increased risk of RPL with a gene dosage effect...
  48. ncbi request reprint Platelet recovery in patients with idiopathic thrombocytopenic purpura after eradication of Helicobacter pylori
    S Hashino
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Hematol 77:188-91. 2003
    ..Although the exact mechanism underlying platelet recovery after H. pylori eradication is not clear, the results of this study indicated that H. pylori eradication treatment is a good option for some patients with chronic ITP...
  49. ncbi request reprint Circulating leptin: a marker of health in female students
    T Kondo
    Gumma Paz College of Nursing, Agastuma gun, Takaya mura, Gumma, Japan
    J Int Med Res 30:109-15. 2002
    ..We suggest that leptin is a useful marker for monitoring good health and may be useful as a motivational aid towards achieving and maintaining a healthy lifestyle...
  50. pmc cpmA, a gene involved in an output pathway of the cyanobacterial circadian system
    M Katayama
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    J Bacteriol 181:3516-24. 1999
    ..This suggests that the interrupted gene in tnp6, named cpmA (circadian phase modifier), is part of a circadian output pathway that regulates the expression rhythms of psbAI, psbAII, and kaiA...
  51. ncbi request reprint Analysis of the steroidogenic acute regulatory protein (StAR) gene in Japanese patients with congenital lipoid adrenal hyperplasia
    J Nakae
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    Hum Mol Genet 6:571-6. 1997
    ....
  52. ncbi request reprint Circadian expression of genes involved in the purine biosynthetic pathway of the cyanobacterium Synechococcus sp. strain PCC 7942
    Y Liu
    Department of Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Mol Microbiol 20:1071-81. 1996
    ..This differential expression pattern may be related to the oxygen sensitivity of amidophosphoribosyltransferase...
  53. ncbi request reprint CikA, a bacteriophytochrome that resets the cyanobacterial circadian clock
    O Schmitz
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Science 289:765-8. 2000
    ..CikA is likely a key component of a pathway that provides environmental input to the circadian oscillator in S. elongatus...
  54. ncbi request reprint Involvement of pRB-related p107 protein in the inhibition of S phase progression in response to genotoxic stress
    T Kondo
    Division of Molecular Oncology, Institute for Genetic Medicine, Department of Medicine II, School of Medicine, Hokkaido University, Kita-ku, Sapporo 060, Japan
    J Biol Chem 276:17559-67. 2001
    ..Because p107 is a major pRB family protein expressed in S phase cells, our results indicate that p107 participates in an inhibition of cell cycle progression in response to DNA damage in S phase cells...
  55. ncbi request reprint Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients
    K Mihara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Japan
    Pharmacol Toxicol 88:267-70. 2001
    ..The present study thus suggests that CYP1A2 polymorphism does not necessarily have predictive value of the steady-state plasma concentration of trazodone or m-chlorophenylpiperazine in most of the smokers treated with trazodone...
  56. pmc A sigma factor that modifies the circadian expression of a subset of genes in cyanobacteria
    N F Tsinoremas
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    EMBO J 15:2488-95. 1996
    ..This work demonstrates a direct link between a transcription factor and the manifestation of circadian gene expression...
  57. pmc ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis
    T Kondo
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 139:749-58. 1997
    ..The physiological relevance of this ERM protein-based microvillar breakdown in apoptosis will be discussed...
  58. ncbi request reprint Identification and characterization of presenilin I-467, I-463 and I-374
    N Sahara
    Department of Molecular Biology, Tokyo Institute of Psychiatry, Japan
    FEBS Lett 381:7-11. 1996
    ..Abnormal behavior of presenilin I on gel electrophoresis was found with affinity-purified antibodies against presenilin I...
  59. pmc Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
    S Yonemura
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 01, Japan
    J Cell Biol 140:885-95. 1998
    ..From these findings, we conclude that ERM proteins bind to integral membrane proteins bearing a positively charged amino acid cluster in their juxta-membrane cytoplasmic domain...
  60. ncbi request reprint Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells
    Y Urata
    Department of Pathological Biochemistry, Nagasaki University School of Medicine, Nagasaki 852, Japan
    J Biol Chem 271:15146-52. 1996
    ....
  61. pmc Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
    M Hirao
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Cell Biol 135:37-51. 1996
    ..These findings indicate that Rho regulates the CD44/ERM complex formation in vivo and that the phosphatidylinositol turnover may be involved in this regulation mechanism...
  62. ncbi request reprint Smoking status, sports participation and mortality from coronary heart disease
    H Noda
    Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, 2 2 Yamadaoka, Shuita shi, Osaka 565 0871 Japan
    Heart 94:471-5. 2008
    ..Since smoking and exercise have opposite effects on coronary risk factors, the hypothesis was proposed that smoking might weaken the protective effect of exercise on prevention of coronary heart disease...
  63. ncbi request reprint Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone
    T Kondo
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Dev Biol 190:142-52. 1997
    ....
  64. ncbi request reprint Detection of antibodies to equine arteritis virus in horse sera using recombinant chimaeric N/G(L) protein
    N Turan
    Department of Microbiology, Veterinary Faculty, University of Istanbul, Avcilar, Istanbul, Turkey
    Vet Rec 161:352-4. 2007
  65. doi request reprint Coffee consumption and risk of endometrial cancer: a prospective study in Japan
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:2406-10. 2008
    ..Coffee consumption may be associated with a decreased risk of endometrial cancer...
  66. ncbi request reprint Familial essential thrombocythemia associated with one-base deletion in the 5'-untranslated region of the thrombopoietin gene
    T Kondo
    Third Department of Internal Medicine and the Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    Blood 92:1091-6. 1998
    ..Based on our findings, we propose that this region of the TPO gene may play a crucial role in regulating TPO expression. Our results strongly suggest that the identified mutation leads to familial ET...
  67. ncbi request reprint Difference in the occurrence of cardiovascular events according to class of antihypertensive agent, based on a follow-up study of Japanese hypertension patients
    M Uchiyama
    Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, Japan
    Jpn Heart J 42:585-95. 2001
    ..The results suggest that the calcium antagonists used in Japan during the period of 1985-1990 constituted a potential risk for the occurrence of cardiovascular events...
  68. ncbi request reprint Association of the TaqI A polymorphism of the dopamine D(2) receptor gene with predisposition to neuroleptic malignant syndrome
    A Suzuki
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Am J Psychiatry 158:1714-6. 2001
    ..Therefore, the authors examined the association between the TaqI A polymorphism of the dopamine D(2) receptor gene (DRD(2)), which alters DRD(2) density and function, and the development of neuroleptic malignant syndrome...
  69. ncbi request reprint Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins
    M Yokouchi
    Departments of Cell Biology, Orthopaedics, and Genetics, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Biol Chem 276:35185-93. 2001
    ..Thus, in addition to mediating the ubiquitination of activated receptor tyrosine kinases, c-Cbl also acts as a ubiquitin ligase for the non-receptor tyrosine kinase Src, thereby down-regulating Src...
  70. ncbi request reprint Impairment of glutathione metabolism in human gastric epithelial cells treated with vacuolating cytotoxin from Helicobacter pylori
    M Kimura
    Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, Nagasaki 852-8521, Japan
    Microb Pathog 31:29-36. 2001
    ..These results suggested that VacA impairs GSH metabolism in the gastric epithelial cells, which weakens the resistance of the cells against oxidative stress or cellular redox regulation by GSH...
  71. pmc Suppression of temperature-sensitivity of a dnaA46 mutant by excessive DNA supercoiling
    T Kondo
    Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Biochem J 348:375-9. 2000
    ..The dnaA46 mutant showed higher sensitivity to nalidixic acid, a DNA-relaxing drug, than did the wild-type cells under the conditions of high temperatures and high concentrations of NaCl...
  72. ncbi request reprint Genomic organization and expression analysis of the mouse qkI locus
    T Kondo
    Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, 4 24 1 Kuhonji, Kumamoto 862 0976, Japan
    Mamm Genome 10:662-9. 1999
    ..Alternative transcripts that share the same 3'-UTR showed very similar expression patterns, suggesting a regulatory role of the 3'-UTRs in qkI gene expression...
  73. ncbi request reprint Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53
    N Shinobu
    Departments of Viral Oncology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Biol Chem 274:17003-10. 1999
    ....
  74. ncbi request reprint Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss
    Y Saijo
    Department of Public Health and Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mol Hum Reprod 10:729-33. 2004
    ..71-1.88, CYP1B1: Leu/Leu (reference); Leu/Val and Val/Val, OR = 1.18; 95% CI = 0.68-2.02]. The present study suggests that the Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not major genetic regulators in RPL...
  75. ncbi request reprint Alteration in levels of unsaturated fatty acids in mutants of Escherichia coli defective in DNA replication
    E Suzuki
    Laboratory for Pharmacokinetics, Research and Development Division, Hoechst Marion Roussel, Ltd, Kawagoe, Japan
    Biol Pharm Bull 21:657-61. 1998
    ..These results suggest that the inhibition of DNA replication causes a lower level of unsaturation of fatty acids in Escherichia coli cells...
  76. ncbi request reprint Risk factors of biliary tract cancer in a large-scale population-based cohort study in Japan (JPHC study); with special focus on cholelithiasis, body mass index, and their effect modification
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Causes Control 19:33-41. 2008
    ..Particular focus was placed on a history of cholelithiasis, body mass index (BMI), and their effect modification, and whether risk differs by cancer subsite, namely by gallbladder cancer and extrahepatic bile duct cancer...