T Kojima

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Plasma levels of syndecan-4 (ryudocan) are elevated in patients with acute myocardial infarction
    T Kojima
    Department of Medical Technology, Nagoya University School of Health Sciences, Japan
    Thromb Haemost 85:793-9. 2001
  2. doi request reprint p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation
    A Furuhata
    Nagoya University Graduate School of Medicine, Nagoya University School of Health Sciences, Nagoya, Japan
    Biochem Biophys Res Commun 383:411-6. 2009
  3. doi request reprint GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines
    A Furuhata
    Department of Medical Technology, Nagoya University Graduate School of Health Sciences, Nagoya, Japan
    Leukemia 23:1270-7. 2009
  4. pmc Nagoya university training system for neuroendovascular therapists
    S Miyachi
    Division of Endovascular Neurosurgery, Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya Japan
    Interv Neuroradiol 10:103-6. 2004
  5. ncbi request reprint Cell type-specific localization of sphingosine kinase 1a in human tissues
    T Murate
    Nagoya University School of Health Science, Nagoya, Japan
    J Histochem Cytochem 49:845-55. 2001
  6. ncbi request reprint Triple anterior chamber after full-thickness lamellar keratoplasty for lattice corneal dystrophy
    K Hirano
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Cornea 20:530-3. 2001
  7. ncbi request reprint Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis
    N Ishiguro
    Department of Orthopaedic Surgery, Nagoya University, School of Medicine, Japan
    Arthritis Rheum 44:2503-11. 2001
  8. ncbi request reprint Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice
    K Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
    J Thromb Haemost 3:1495-502. 2005
  9. pmc Treatment Strategy for Cerebral Aneurysms Based on the Evidence of the Efficacy of GDC Embolization
    S Miyachi
    Division of Endovascular Neurosurgery, Department of Neursosurgery, Study Group of Endovascualr Neurosurgery, Nagoya University Graduate School of Medicine JShowa ku, Nagoya Japan
    Interv Neuroradiol 9:51-5. 2003
  10. pmc Dural arteriovenous fistula at the anterior condylar confluence
    S Miyachi
    Department of Neurosurgery, Nagoya University Graduate School of Medicine Showa ku Nagoya, Japan
    Interv Neuroradiol 14:303-11. 2008

Detail Information

Publications42

  1. ncbi request reprint Plasma levels of syndecan-4 (ryudocan) are elevated in patients with acute myocardial infarction
    T Kojima
    Department of Medical Technology, Nagoya University School of Health Sciences, Japan
    Thromb Haemost 85:793-9. 2001
    ..Taken together, it is suggested that syndecan-4 is induced by hypoxia stimuli in ischemic heart tissues, and may function as a tissue-repair molecule via biological mediators such as heparin-binding growth factors...
  2. doi request reprint p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation
    A Furuhata
    Nagoya University Graduate School of Medicine, Nagoya University School of Health Sciences, Nagoya, Japan
    Biochem Biophys Res Commun 383:411-6. 2009
    ..Similar findings were observed in BCR/ABL-transfected Ba/F3. Our results elucidate the regulatory mechanism by which JAK2V617F modulates Skp2 gene expression through the STAT transcription factors...
  3. doi request reprint GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines
    A Furuhata
    Department of Medical Technology, Nagoya University Graduate School of Health Sciences, Nagoya, Japan
    Leukemia 23:1270-7. 2009
    ..Taken together, these results suggest that GATA-1 and/or GATA-2 binding to a GATA site of the 3' enhancer of WT1 played an important role in WT1 gene expression...
  4. pmc Nagoya university training system for neuroendovascular therapists
    S Miyachi
    Division of Endovascular Neurosurgery, Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya Japan
    Interv Neuroradiol 10:103-6. 2004
    ..Thus, neuroendovascular therapies are situated as one of the important tratment modalities for neurosurgical diseases (1,2). We studied our present states of the endovascular neurosurgery and introduce our training system...
  5. ncbi request reprint Cell type-specific localization of sphingosine kinase 1a in human tissues
    T Murate
    Nagoya University School of Health Science, Nagoya, Japan
    J Histochem Cytochem 49:845-55. 2001
    ..J Histochem Cytochem 49:845-855, 2001)..
  6. ncbi request reprint Triple anterior chamber after full-thickness lamellar keratoplasty for lattice corneal dystrophy
    K Hirano
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Cornea 20:530-3. 2001
    ..To report a patient with lattice corneal dystrophy type I (LCDI) who developed a triple anterior chamber after full-thickness lamellar keratoplasty (LKP)...
  7. ncbi request reprint Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis
    N Ishiguro
    Department of Orthopaedic Surgery, Nagoya University, School of Medicine, Japan
    Arthritis Rheum 44:2503-11. 2001
    ..To determine interrelationships in matrix turnover in articular cartilage and joint inflammation in rheumatoid arthritis (RA)...
  8. ncbi request reprint Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice
    K Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
    J Thromb Haemost 3:1495-502. 2005
    ..We have begun to investigate the expression of a primary inhibitor of fibrinolysis, plasminogen activator inhibitor-1 (PAI-1), in association with tissue thrombosis, using restraint-stressed obese mice...
  9. pmc Treatment Strategy for Cerebral Aneurysms Based on the Evidence of the Efficacy of GDC Embolization
    S Miyachi
    Division of Endovascular Neurosurgery, Department of Neursosurgery, Study Group of Endovascualr Neurosurgery, Nagoya University Graduate School of Medicine JShowa ku, Nagoya Japan
    Interv Neuroradiol 9:51-5. 2003
    ..Therefore, saccular embolization of endovascularly difficult, very small AcomA aneurysms and large C2 aneurysm with visual symptoms should be used sparingly based on a risk-benefit assessment...
  10. pmc Dural arteriovenous fistula at the anterior condylar confluence
    S Miyachi
    Department of Neurosurgery, Nagoya University Graduate School of Medicine Showa ku Nagoya, Japan
    Interv Neuroradiol 14:303-11. 2008
    ..Evaluating the angioarchitecture using the selective three-dimensional angiography and tomographic imaging greatly helps to determine the target and strategy of endovascular treatment for these DAVF...
  11. pmc Computer simulation of flow dynamics in paraclinoidal aneurysms
    N Kobayashi
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya Japan
    Interv Neuroradiol 11:197-203. 2005
    ..It should be considered in the treatment of such aneurysms...
  12. ncbi request reprint Optical coherence tomography for the noninvasive evaluation of the cornea
    K Hirano
    Department of Ophthalmology, Nagoya University School of Medicine, Aichi, Japan
    Cornea 20:281-9. 2001
    ..To determine the optical coherence tomographic (OCT) characteristics of normal corneas and to characterize the OCT images of abnormal corneal lesions...
  13. ncbi request reprint Successful culture and sustainability in vivo of gene-modified human oral mucosal epithelium
    H Mizuno
    Department of Oral Surgery, Nagoya University School of Medicine, Japan
    Hum Gene Ther 10:825-30. 1999
    ..These results confirmed that the oral mucosal epithelium is an ideal target tissue for gene therapy or tissue engineering...
  14. ncbi request reprint Regulation of murine protein C gene expression in vivo: effects of tumor necrosis factor-alpha, interleukin-1, and transforming growth factor-beta
    K Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Showa, Japan
    Thromb Haemost 82:1297-301. 1999
    ..These observations suggest that TNF-alpha and IL-1 may contribute to an increase in the procoagulant potential by downregulation of protein C synthesis in the tissues during inflammatory processes...
  15. doi request reprint A phase II study of radical surgery followed by postoperative chemotherapy with S-1 for gastric carcinoma with free cancer cells in the peritoneal cavity (CCOG0301 study)
    Y Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Eur J Surg Oncol 35:1158-63. 2009
    ..A standard treatment for such patients remains to be established...
  16. ncbi request reprint Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12
    S Sobue
    Nagoya University Graduate School of Medicine, Nagoya University School of Health Sciences, Daiko minami, Nagoya, Japan
    J Neurochem 95:940-9. 2005
    ..These results suggest the signal transduction pathway from NGF receptor TrkA to transcription factor Sp1 protein binding to the promoter Sp1-like motif in NGF-induced rat SPHK1 gene expression...
  17. doi request reprint v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins
    S Sobue
    Department of Medical Technology, Nagoya University Graduate School of Health Sciences, Nagoya, Japan
    Oncogene 27:6023-33. 2008
    ..Our results showed, for the first time, a novel mechanism of v-Src-induced SPHK1 overexpression...
  18. ncbi request reprint Ewing's sarcoma fusion protein, EWS/Fli-1 and Fli-1 protein induce PLD2 but not PLD1 gene expression by binding to an ETS domain of 5' promoter
    R Kikuchi
    Nagoya University Graduate School of Medicine, Nagoya University School of Health Sciences, Nagoya, Aichi, Japan
    Oncogene 26:1802-10. 2007
    ..Electrophoresis mobility shift assay using truncated proteins showed that both DNA-binding domain and trans-activating domain were necessary for the enhanced gene expression of PLD2...
  19. ncbi request reprint Syndecan-4 deficiency increases susceptibility to kappa-carrageenan-induced renal damage
    K Ishiguro
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan
    Lab Invest 81:509-16. 2001
    ..After administration of kappa-carrageenan, blood urea nitrogen of Synd4(-/-) mice was significantly higher than that of Synd4(+/+) mice. Thus, syndecan-4 may function to prevent kappa-carrageenan deposition in the collecting ducts...
  20. ncbi request reprint Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes
    S Sobue
    Leukemia 20:2042-6. 2006
  21. ncbi request reprint Osteogenic effect of interleukin-11 and synergism with ascorbic acid in human periodontal ligament cells
    E R Leon
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Periodontal Res 42:527-35. 2007
    ..Interleukin-11 is a multifunctional cytokine known to participate actively in bone metabolism. The purpose of this study was to examine the effect of interleukin-11 on the osteoblastic differentiation of periodontal ligament cells...
  22. doi request reprint Effects of compression force on fibroblast growth factor-2 and receptor activator of nuclear factor kappa B ligand production by periodontal ligament cells in vitro
    R Nakajima
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    J Periodontal Res 43:168-73. 2008
    ..In the present study, we investigated the effects of compression force on fibroblast growth factor-2 and RANKL production by human periodontal ligament cells...
  23. pmc Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice
    Y Suzuki
    Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, California 94301, USA
    Infect Immun 65:2339-45. 1997
    ..The protective activity of IL-6 against development of TE appears to be through its ability to stimulate IFN-gamma production and induce infiltration and accumulation of different T-cell subsets in brains of infected mice...
  24. ncbi request reprint Molecular cloning and expression of two distinct cDNA-encoding heparan sulfate proteoglycan core proteins from a rat endothelial cell line
    T Kojima
    Department of Biology, Massachusetts, Institute of Technology, Cambridge 02139
    J Biol Chem 267:4870-7. 1992
    ..Ryudocan and syndecan mRNAs were abundantly expressed in both populations representing about 0.1-0.5% of mRNA...
  25. ncbi request reprint Human ryudocan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor
    T Kojima
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya 466, Japan
    J Biol Chem 271:5914-20. 1996
    ..These findings suggest that ryudocan may possess multiple biological functions, such as bFGF modulation, neurite growth promotion, and anticoagulation, via HS-binding effectors in the cellular microenvironment...
  26. ncbi request reprint Isolation and characterization of ryudocan and syndecan heparan sulfate proteoglycans, core proteins, and cDNAs from a rat endothelial cell line
    N W Shworak
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Haemostasis 23:161-76. 1993
    ..Ryudocan and syndecan mRNAs were abundantly expressed in both populations representing about 0.1-0.5% of mRNA...
  27. ncbi request reprint A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5
    N Yamaguchi
    Department of Cell Biology, Research Institute for Neurological Disease and Geriatrics, Kyoto, Japan
    J Biol Chem 269:805-8. 1994
    ..The same or homologous amino acid sequence has not been found in known proteins, demonstrating that MPF is a novel cytokine that has megakaryocyte potentiating activity in the murine assay system...
  28. ncbi request reprint A case of coagulation factor V deficiency caused by compound heterozygous mutations in the factor V gene
    N Yamakage
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, and Division of Transfusion Medicine, Nagoya University Hospital, Japan
    Haemophilia 12:172-8. 2006
    ..Taken together, it seems to suggest that each gene mutation could be separately responsible for severe FV deficiency, while this phenotype is due to the in-trans combination of the two defects...
  29. ncbi request reprint Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice
    M Hayashi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
    J Thromb Haemost 4:177-85. 2006
    ..We previously reported that the targeted disruption of murine antithrombin (AT) gene resulted in embryonic lethality before 16.5 gestational days (gd) because of severe cardiac and hepatic thrombosis...
  30. ncbi request reprint A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro
    T Sugiyama
    Department of Hematopoietic Factors, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Biochemistry 39:15817-25. 2000
    ..These results raise the possibility that this newly identified receptor, which is expressed in the liver, may play a physiological role in the uptake of apoE-containing lipoproteins...
  31. ncbi request reprint Syndecan-4 deficiency impairs the fetal vessels in the placental labyrinth
    K Ishiguro
    Department of Biochemistry, Nagoya University School of Medicine, Showa Ku, Nagoya, Aichi, Japan
    Dev Dyn 219:539-44. 2000
    ..This article is the first report demonstrating that among a large number of core proteins of heparan sulfate proteoglycans, a defect of a single core protein caused impaired anticoagulation in a specific site...
  32. ncbi request reprint Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135
    T Kojima
    Department of Molecular Genetic Research, National Institute for Longevity Sciences NILS, Morioka cho, Oobu, Aichi, 474 8522, Japan
    Biochem Biophys Res Commun 284:1039-47. 2001
    ..The Sck-pp135 interaction was reduced by Src kinase inhibitors. These results suggest that Sck, but not N-Shc nor Shc, transmit signals in conjunction with pp135 following Src activation and/or calcium entry in the cell...
  33. ncbi request reprint TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles
    T Kojima
    Department of Hematopoietic Factors, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 275:20742-7. 2000
    ..The Troy gene is located near the waved coat (Wc) locus, a mutant related to abnormalities in skin and hair...
  34. ncbi request reprint Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions
    K Ishiguro
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 275:5249-52. 2000
    ..When the signal is delivered as a substratum-bound form, other molecule(s) also participate(s) in the signal reception...
  35. ncbi request reprint Expression of protein S in the murine heart and cultured mouse cardiomyocytes is down-regulated by cytokines
    T Shimokawa
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Thromb Haemost 86:623-9. 2001
    ....
  36. ncbi request reprint Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion
    M Ueno
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1, Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 287:501-6. 2001
    ..5 dorsal aorta. These data suggest that endomucin-1 may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis...
  37. ncbi request reprint Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice
    K Ishiguro
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan
    J Biol Chem 276:47483-8. 2001
    ..These results indicate that syndecan-4 could be involved in prevention of endotoxin shock, at least partly through the inhibitory action of transforming growth factor-beta1 on IL-1beta production...
  38. ncbi request reprint The disabled 1 gene is disrupted by a replacement with L1 fragment in yotari mice
    T Kojima
    Laboratory for Developmental Neurobiology, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Brain Res Mol Brain Res 75:121-7. 2000
    ..This method should greatly contribute to analyses of the early anatomical and physiological consequences of the yotari mutation...
  39. ncbi request reprint Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery
    T Kojima
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Thromb Res 104:301-7. 2001
    ..While tranexamic acid had no effects on the other important fibrinolytic inhibitors like PAI-1 and alpha2-antiplasmin...
  40. ncbi request reprint Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions
    S Kunishima
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    J Hum Genet 46:722-9. 2001
    ..Thus, MHA, SBS, and FTNS appear to represent a class of allelic disorders with variable phenotypic diversity...
  41. ncbi request reprint Gene expression of leukemia inhibitory factor (LIF) and macrophage colony stimulating factor (M-CSF) in bovine endometrium during early pregnancy
    K Oshima
    National Agricultural Research Center for Western Region, Yoshinaga 60, Kawai, Oda, Shimane 694 0013, Japan
    Theriogenology 60:1217-26. 2003
    ..These results suggest that LIF and M-CSF are produced in the endometrium and may play different roles in early and mid-pregnancy...
  42. ncbi request reprint Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice
    K Yamamoto
    Thromb Res 120:143-4. 2007