Seiji Kojima

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc Long-term outcome after immunosuppressive therapy with horse or rabbit antithymocyte globulin and cyclosporine for severe aplastic anemia in children
    Dae Chul Jeong
    Haematologica 99:664-71. 2014
  2. ncbi request reprint Treatment of acquired aplastic anemia in children
    Seiji Kojima
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hematology 17:S11-4. 2012
  3. ncbi request reprint Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan Marrow Donor Program
    Seiji Kojima
    Dept of Developmental Pediatrics, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Blood 100:799-803. 2002
  4. ncbi request reprint Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children
    Seiji Kojima
    Department of Developmental Pediatrics, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Blood 100:786-90. 2002
  5. ncbi request reprint Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia
    S Kojima
    Japan Childhood Aplastic Anemia Study Group, Nagoya, Japan
    Blood 96:2049-54. 2000
  6. ncbi request reprint Long-term outcome of acquired aplastic anaemia in children: comparison between immunosuppressive therapy and bone marrow transplantation
    S Kojima
    Department of Developmental Paediatrics, Nagoya University School of Medicine, Japan
    Br J Haematol 111:321-8. 2000
  7. ncbi request reprint Aplastic anemia
    Seiji Kojima
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 82:408-11. 2005
  8. ncbi request reprint Unrelated donor marrow transplantation in children with severe aplastic anaemia using cyclophosphamide, anti-thymocyte globulin and total body irradiation
    S Kojima
    Department of Developmental Paediatrics, Nagoya University School of Medicine, Nagoya, Japan
    Br J Haematol 114:706-11. 2001
  9. ncbi request reprint Immunosuppressive therapy with horse anti-thymocyte globulin and cyclosporine as treatment for fulminant aplastic anemia in children
    Hiroshi Yagasaki
    Department of Pediatrics, School of Medicine, Nihon University, 30 1 Ohyaguchi Kamicho, Itabashi ku, 173 8610, Tokyo, Japan
    Ann Hematol 93:747-52. 2014
  10. doi request reprint Clinical impact of HLA-DR15, a minor population of paroxysmal nocturnal haemoglobinuria-type cells, and an aplastic anaemia-associated autoantibody in children with acquired aplastic anaemia
    Nao Yoshida
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 142:427-35. 2008

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. pmc Long-term outcome after immunosuppressive therapy with horse or rabbit antithymocyte globulin and cyclosporine for severe aplastic anemia in children
    Dae Chul Jeong
    Haematologica 99:664-71. 2014
    ..However, our results justify the use of rabbit antithymocyte globulin as first-line therapy if horse antithymocyte globulin is not available. ..
  2. ncbi request reprint Treatment of acquired aplastic anemia in children
    Seiji Kojima
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hematology 17:S11-4. 2012
    ..The incidence of AA is approximately 3 fold more common in East Asia than in Europe and United States where yearly incidence rates are approximately two patients per one million...
  3. ncbi request reprint Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan Marrow Donor Program
    Seiji Kojima
    Dept of Developmental Pediatrics, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Blood 100:799-803. 2002
    ..Matching of HLA class I alleles and improvement of preparative regimens should result in improved outcomes in patients with severe aplastic anemia who receive transplants from unrelated donors...
  4. ncbi request reprint Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children
    Seiji Kojima
    Department of Developmental Pediatrics, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Blood 100:786-90. 2002
    ..The present study suggests a close relationship between long-term use of G-CSF and secondary MDS in nonresponders to IST...
  5. ncbi request reprint Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia
    S Kojima
    Japan Childhood Aplastic Anemia Study Group, Nagoya, Japan
    Blood 96:2049-54. 2000
    ..Because the results of IST were encouraging, it is suggested that children with AA receive IST as first-line therapy if there is no human leukocyte antigen-matched sibling donor...
  6. ncbi request reprint Long-term outcome of acquired aplastic anaemia in children: comparison between immunosuppressive therapy and bone marrow transplantation
    S Kojima
    Department of Developmental Paediatrics, Nagoya University School of Medicine, Japan
    Br J Haematol 111:321-8. 2000
    ..40). We recommend BMT as first-line therapy in paediatric severe AA patients with an HLA-matched family donor. Alternative donor BMT is recommended as salvage therapy in patients who relapse or do not respond to initial IST...
  7. ncbi request reprint Aplastic anemia
    Seiji Kojima
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 82:408-11. 2005
  8. ncbi request reprint Unrelated donor marrow transplantation in children with severe aplastic anaemia using cyclophosphamide, anti-thymocyte globulin and total body irradiation
    S Kojima
    Department of Developmental Paediatrics, Nagoya University School of Medicine, Nagoya, Japan
    Br J Haematol 114:706-11. 2001
    ..Considering our encouraging results, unrelated donor transplantation for SAA is recommended as a salvage therapy in non-responders to IST...
  9. ncbi request reprint Immunosuppressive therapy with horse anti-thymocyte globulin and cyclosporine as treatment for fulminant aplastic anemia in children
    Hiroshi Yagasaki
    Department of Pediatrics, School of Medicine, Nihon University, 30 1 Ohyaguchi Kamicho, Itabashi ku, 173 8610, Tokyo, Japan
    Ann Hematol 93:747-52. 2014
    ..5, 95.8, and 96.8 %). These findings indicate that IST with ATG and CsA is justified as a first-line treatment for children with FAA who lack a human leukocyte antigen-matched sibling donor. ..
  10. doi request reprint Clinical impact of HLA-DR15, a minor population of paroxysmal nocturnal haemoglobinuria-type cells, and an aplastic anaemia-associated autoantibody in children with acquired aplastic anaemia
    Nao Yoshida
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 142:427-35. 2008
    ..53.1%) or anti-PMS1 antibody (40.0% vs. 59.1%). The current study did not confirm a correlation between these markers and the response to IST, suggesting that there is a difference in the pathophysiologies of adult and paediatric AA...
  11. ncbi request reprint Feasibility and results of bone marrow transplantation from an HLA-mismatched unrelated donor for children and young adults with acquired severe aplastic anemia
    Hiroshi Yagasaki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 85:437-42. 2007
    ..All patients are alive at 9 to 56 months after transplantation (median, 33 months). Considering our encouraging results, HLA-mismatched unrelated-donor BMT for SAA is feasible as a salvage therapy for nonresponders to IST...
  12. ncbi request reprint Unrelated cord blood transplantation for severe aplastic anemia
    Ayami Yoshimi
    Department of HSCT Data Management, Nagoya University, School of Medicine, Nagoya, Japan
    Biol Blood Marrow Transplant 14:1057-63. 2008
    ..4%-96.9%). This result suggests that UCBT using the optimal conditioning regimen can be a salvage treatment for patients without a suitable bone marrow donor and warrants evaluation in further prospective studies...
  13. doi request reprint Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bone marrow transplantation from unrelated donors: results of matched pair analysis
    Hiroshi Yagasaki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biol Blood Marrow Transplant 15:1603-8. 2009
    ..012). The study shows the superiority of FK/MTX over CsA/MTX in overall survival because of the lower incidence of transplantation-related deaths. A prospective randomized study comparing FK/MTX and CsA/MTX is warranted...
  14. doi request reprint Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8650, Japan
    Int J Hematol 93:186-91. 2011
    ..28.6%, p = 0.006). In summary, the survival outcomes of pediatric patients with CML were dramatically improved by treatment with IM compared to HSCT...
  15. doi request reprint Total body irradiation and melphalan as a conditioning regimen for children with hematological malignancies undergoing transplantation with stem cells from HLA-identical related donors
    Nobuhiro Watanabe
    Children s Medical Center, Japanese Red Cross, Nagoya, Japan
    Pediatr Transplant 15:642-9. 2011
    ..2%, 88.1%, and 23.1%, respectively (p < 0.05). MEL/TBI for pediatric patients with hematological malignancies was associated with lower relapse rates and no increase in toxicity, resulting in better survival...
  16. ncbi request reprint Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Transplant 13:831-7. 2009
    ..Event-free survival did not significantly differ between patients with and without ES regardless of the presence of malignant or non-malignant diseases...
  17. pmc Predicting response to immunosuppressive therapy in childhood aplastic anemia
    Nao Yoshida
    Department of Hematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Haematologica 96:771-4. 2011
    ..The finding that response rate worsens with increasing interval between diagnosis and treatment highlights the importance of prompt immunosuppressive therapy for patients with aplastic anemia...
  18. doi request reprint Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome
    Asahito Hama
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 140:552-61. 2008
    ..81) with a median follow-up of 78 months (range, 20-243 months). Our study shows the diverse heterogeneity of childhood AMKL and the need for subclassification according to cytogenetic and morphological features...
  19. ncbi request reprint Correlation of CYP2C19 phenotype with voriconazole plasma concentration in children
    Atsushi Narita
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 35:e219-23. 2013
    ..Here, we report an analysis of CYP2C19 phenotype and voriconazole plasma concentrations in children...
  20. doi request reprint Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia
    Hiroshi Yagasaki
    Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan
    Blood 118:3186-90. 2011
    ..However, if such a donor is not available, any single-allele or multiple-allele (HLA-C, -DRB1, -DQB1) mismatched donor is acceptable as an unrelated donor for patients with severe aplastic anemia...
  21. doi request reprint Prognostic factors for outcomes of pediatric patients with refractory or relapsed acute leukemia undergoing allogeneic progenitor cell transplantation
    Nobuhiro Watanabe
    Division of Hematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Biol Blood Marrow Transplant 17:516-23. 2011
    ....
  22. pmc Relapse of aplastic anemia in children after immunosuppressive therapy: a report from the Japan Childhood Aplastic Anemia Study Group
    Takuya Kamio
    Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Haematologica 96:814-9. 2011
    ..However, detailed analyses of relapses in aplastic anemia children are limited...
  23. doi request reprint Outcome of 125 children with chronic myelogenous leukemia who received transplants from unrelated donors: the Japan Marrow Donor Program
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biol Blood Marrow Transplant 16:231-8. 2010
    ..These findings provide important information for assessing the indications for and improving outcome in unrelated BMT for the treatment of pediatric CML...
  24. doi request reprint Downregulation of GATA-2 and overexpression of adipogenic gene-PPARgamma in mesenchymal stem cells from patients with aplastic anemia
    Yinyan Xu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Exp Hematol 37:1393-9. 2009
    ..Decreased expression of GATA-2 might be responsible for the pathogenesis and development of the clinical features of the disease...
  25. doi request reprint Treatment of children with refractory anemia: the Japanese Childhood MDS Study Group trial (MDS99)
    Daisuke Hasegawa
    Department of Pediatrics, St Luke s International Hospital, Tokyo, Japan
    Pediatr Blood Cancer 53:1011-5. 2009
    ..Several reports have shown the efficacy of immunosuppressive therapy (IST) in adult patients with refractory anemia (RA), but its safety and efficacy remains to be fully elucidated in childhood RA...
  26. ncbi request reprint Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR; comparison to detection of viral DNA in plasma by qualitative PCR
    Masaru Ihira
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Microbiol Immunol 46:701-5. 2002
    ..033). In patients with HHV-6 viremia, mean HHV-6 DNA copy number was higher in the samples collected at 2 weeks after BMT than the samples collected at any other time period...
  27. doi request reprint Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia
    Nao Yoshida
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Pediatr Res 65:334-40. 2009
    ..001). All patients who died after relapse had PTPN11 mutation. These results suggest that JMML with PTPN11 mutation might be a distinct subgroup with specific clinical characteristics and poor outcome...
  28. doi request reprint Plasmacytoid dendritic cell leukemia in children
    Asahito Hama
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 31:339-43. 2009
    ..The CD4, CD56, CD3, CD13, CD19, CD33 profile is highly suggestive of this disease, and the CD123 and blood dendritic cell antigen-2 markers are useful in helping to diagnose pDC leukemia...
  29. ncbi request reprint Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    J Med Virol 81:1399-402. 2009
    ..8 x 10(2) copies/ml of whole blood, respectively, suggesting that the viruses were associated with the clinical condition. Recognizing that coinfection with these viruses may modulate the clinical course of disease is important...
  30. doi request reprint Reduced-intensity conditioning for alternative donor hematopoietic stem cell transplantation in patients with dyskeratosis congenita
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Clinical Research Center for Blood Diseases, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Pediatr Transplant 15:161-6. 2011
    ..They were alive 10, 66, and 72 months after transplantation, respectively. Long-term follow-up is crucial to determine the late effects of our conditioning regimen...
  31. doi request reprint CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya, Aichi 466 8650, Japan
    Int J Hematol 93:779-81. 2011
    ..Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD...
  32. doi request reprint Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation
    Itzel Bustos Villalobos
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Blood 115:3158-61. 2010
    ..Accordingly, the status of mismatched HLA on relapsed leukemic cells should be checked before donor lymphocyte infusion...
  33. doi request reprint Clinical and virological characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Infect Dis 46:1525-34. 2008
    ..Recently, hematopoietic stem cell transplantation (HSCT) has been introduced and has the potential to become a standard treatment, although guidelines for HSCT to treat chronic active EBV infection have not yet been proposed...
  34. doi request reprint Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 58:780-4. 2012
    ..Idiopathic pneumonia syndrome (IPS) is a severe complication that can occur after hematopoietic stem cell transplantation (HSCT) and is often associated with a fatal outcome despite intensive supportive care...
  35. ncbi request reprint [Bone marrow findings of childhood aplastic anemia: analyses of 140 cases by central reviewers]
    Asahito Hama
    Department of Pediatrics, Nagoya University Graduate School of Medicine
    Rinsho Ketsueki 52:653-8. 2011
    ..The response rate to immunosuppressive therapy did not differ among the 3 groups. To demonstrate whether the two diseases are truly different entities, it is necessary to compare molecular backgrounds between the AA and RCC groups...
  36. ncbi request reprint Outcome of bone marrow transplantation from HLA-identical sibling donor in children with hematological malignancies using methotrexate alone as prophylaxis for graft-versus-host disease
    Nobuhiro Watanabe
    Division of Hematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Int J Hematol 88:575-82. 2008
    ..1 and 39.5%, respectively. These results suggest that GVHD prophylaxis with MTX alone is safe and effective in young children under 10 years old at transplantation and in a setting other than female donor to male recipient...
  37. ncbi request reprint Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein-Barr virus infection
    Yukiko Shibata
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 78:770-9. 2006
    ..Collectively, these findings are critical to clarify further the pathogenesis of chronic active EBV infection and aid in the development of effective treatment strategies...
  38. ncbi request reprint Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infant cytomegalovirus infection mimicking juvenile myelomonocytic leukemia
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Leuk Res 35:1261-4. 2011
    ..We conclude that patients with CMV infection cannot be discriminated from patients with JMML by this new diagnostic method...
  39. pmc Simultaneous quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay
    Kaoru Wada
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Clin Microbiol 45:1426-32. 2007
    ..These results demonstrate that whole blood is more suitable for the quantification of EBV DNA in transplant patients. However, a cutoff value with clinical relevance still needs to be determined...
  40. ncbi request reprint Congenital erythroid and myeloid hypoplasia terminating myelodysplastic syndrome
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 30:692-5. 2008
    ..She was transplanted with cord blood from an unrelated human leukocyte antigen-matched donor and has since remained in complete remission for 20 months...
  41. doi request reprint Natural history of transfusion-independent non-severe aplastic anemia in children
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Shouwa ku, Nagoya 466 8550, Japan
    Int J Hematol 89:409-13. 2009
    ....
  42. doi request reprint Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 197:663-6. 2008
    ..These genes may be associated with the inflammatory reaction or with cell proliferation...
  43. ncbi request reprint Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 191:531-9. 2005
    ..These findings should help to clarify the pathogenesis of CAEBV infection and facilitate the development of more-effective treatments...
  44. doi request reprint Excellent outcome of allogeneic bone marrow transplantation for Fanconi anemia using fludarabine-based reduced-intensity conditioning regimen
    Akira Shimada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Int J Hematol 95:675-9. 2012
    ..BMT using FLU/low-dose CY/ATG -based regimens regardless to the donor is a beneficial therapeutic approach for FA patients...
  45. ncbi request reprint EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases
    Hiroshi Kimura
    Departments of Virology, Nagoya University Graduate School of Medicine, Japan
    Blood 119:673-86. 2012
    ..These data depict clinical characteristics of systemic EBV(+) T/NK-LPD and provide insight into the diagnostic and therapeutic approaches for distinct disease...
  46. ncbi request reprint Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia
    Yoshiyuki Kosaka
    Department of Pediatrics, Hyogo Children Hospital, Hyogo, Japan
    Blood 111:1054-9. 2008
    ..1%, SD) in the SCT group compared with 9.5% (+/- 9.0%) in the IST group (P = .001). These results suggest that SCT from an alternative donor offers a better chance of FFS than a second IST in patients not responding to an initial IST...
  47. doi request reprint Chronologic changes in neonatal EEG findings in periventricular leukomalacia
    Hiroyuki Kidokoro
    Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan
    Pediatrics 124:e468-75. 2009
    ..This study sought to clarify chronologic changes in neonatal electroencephalographic (EEG) findings in periventricular leukomalacia (PVL)...
  48. ncbi request reprint Lack of CD4⁺CD25⁺FOXP3⁺ regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease
    Yu Hirabayashi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Eur J Pediatr 172:833-7. 2013
    ..Two of these four patients displayed coronary abnormalities, and one of these two patients developed coronary aneurysm...
  49. ncbi request reprint Evaluation of apoptosis in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 78:400-7. 2006
    ..These results suggest that apoptosis, which is dependent on the EBV load and could be mediated by TNF-alpha, plays a major role in the pathophysiology of EBV-associated HLH...
  50. doi request reprint Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nat Genet 45:937-41. 2013
    ..Our findings provide new insights into the pathogenesis and progression of JMML. ..
  51. doi request reprint Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases
    Shinji Kawabe
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 103:1481-8. 2012
    ....
  52. doi request reprint Mutations profile of polycythemia vera and essential thrombocythemia among Japanese children
    Olfat Ismael
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Pediatr Blood Cancer 59:530-5. 2012
    ..Acquired somatic mutations of JAK2 have been reported to play a pivotal role in the pathogenesis of BCR-ABL1-negative myeloproliferative neoplasm (MPN). However, the molecular characteristics of childhood MPN remain to be elucidated...
  53. doi request reprint Molecular lesions in childhood and adult acute megakaryoblastic leukaemia
    Asahito Hama
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 156:316-25. 2012
    ..ASXL1, IDH1/2, DNMT3A, RUNX1 and CBL mutations were not found in any of the patient group studied, while NRAS mutation was identified in two patients with paediatric non-DS-AMKL...
  54. doi request reprint Quantification of granulocyte-macrophage colony-stimulating factor hypersensitivity in juvenile myelomonocytic leukemia by 3H-thymidine assay
    Makito Tanaka
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Leuk Res 32:1036-42. 2008
    ..This method will be useful not only in the diagnosis of JMML, but also to evaluate the difference of GM-CSF sensitivity among patients...
  55. doi request reprint Identification of Epstein-Barr virus-infected CD27+ memory B-cells in liver or stem cell transplant patients
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gen Virol 92:2590-5. 2011
    ..88, P < 0.0001). The FISH assay enabled us to characterize EBV-infected cells and perform a quantitative analysis in patients with EBV infection after stem cell/liver transplantation...
  56. ncbi request reprint Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients
    Ayano Fujita
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 4701192, Japan
    J Infect 57:241-8. 2008
    ..These results imply that proinflammatory cytokines, in particular IL-6 and TNF-alpha, play a role in the pathogenesis of HHV-6 reactivation after HSCT...
  57. ncbi request reprint Risk factors for early death in neonates with Down syndrome and transient leukaemia
    Hideki Muramatsu
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Japanese Red Cross Nagoya First Hospital, Aichi, Japan
    Br J Haematol 142:610-5. 2008
    ..5% (6/11) died early]. This stratification system may be useful for identifying high-risk patients who need early therapeutic interventions...
  58. ncbi request reprint Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 200:1078-87. 2009
    ....
  59. ncbi request reprint Induction of complete remission of hypoplastic leukemia with antithymocyte globulin
    Ayami Yoshimi
    Department of Pediatrics and Developmental Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 77:277-81. 2003
    ..These findings suggest the efficacy of antithymocyte globulin in treating certain hypoplastic leukemias...
  60. doi request reprint Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection
    Yoshihiko Kawano
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 208:771-9. 2013
    ..MicroRNAs (miRNAs) are small noncoding RNAs, and EBV encodes multiple miRNAs. Because plasma contains sufficiently stable miRNAs, circulating EBV-associated miRNA profiles were investigated as novel biomarkers in CAEBV infection...
  61. doi request reprint Progressive hearing loss following acquired cytomegalovirus infection in an immunocompromised child
    Ken Kato
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Japan
    Am J Otolaryngol 34:89-92. 2013
    ..This case demonstrates the possibility that, under the immunodeficiency, the acquired CMV infection causes progressive sensorineural hearing loss...
  62. ncbi request reprint De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics
    Olfat Ismael
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Br J Haematol 158:129-37. 2012
    ..Moreover, two patients had constitutional alterations of genes frequently found in AML. Further investigations are required to define the roles of these genetic alterations in the pathogenesis of childhood MDS/MPN-U...
  63. ncbi request reprint Serial morphologic observation of bone marrow in aplastic anemia in children
    Fumio Bessho
    Department of Pediatrics, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Int J Hematol 81:400-4. 2005
    ..An elucidation of the role of mast cells may provide information about the differences between aplastic anemia and MDS or about the transition of aplastic anemia to MDS...
  64. pmc Multiplex real-time PCR assay for simultaneous quantification of BK polyomavirus, JC polyomavirus, and adenovirus DNA
    Yasuhito Funahashi
    Department of Urology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Clin Microbiol 48:825-30. 2010
    ..Since this new assay is rapid, sensitive, and specific, it can be used for quantitative analyses of viruses in urine and serum samples after transplantation...
  65. pmc Intragenic suppressor of a plug deletion nonmotility mutation in PotB, a chimeric stator protein of sodium-driven flagella
    Shiwei Zhu
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Japan
    J Bacteriol 194:6728-35. 2012
    ..We speculate that this α-helix plays a key role in assembly-coupled stator activation...
  66. doi request reprint Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)
    Nozomu Kawashima
    Division of Hematology Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, 3 35, Michishita cho, Nakamura ku, Nagoya, Aichi, 453 8511, Japan
    Int J Hematol 95:577-80. 2012
    ..He received chemotherapy and survived for more than 70 months without transplantation. We speculated that pediatric AML with t(16;21)(q24;q22) showed favorable prognosis, as with t(8;21)(q22;q22)...
  67. ncbi request reprint Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gen Virol 87:1677-83. 2006
    ..These results should help to clarify the pathogenesis of influenza and its neurological complications...
  68. ncbi request reprint A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia
    Yasuhiko Sera
    Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Haematologica 90:1032-41. 2005
    ..Mutations in the neutrophil elastase gene, ELA2, have been reported in patients with CyN and in those with SCN. We examined granulopoietic defects in CyN patients with those in SCN patients...
  69. ncbi request reprint Prospective study of a pirarubicin, intermediate-dose cytarabine, and etoposide regimen in children with Down syndrome and acute myeloid leukemia: the Japanese Childhood AML Cooperative Study Group
    Kazuko Kudo
    Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    J Clin Oncol 25:5442-7. 2007
    ..To evaluate a less intensive chemotherapeutic regimen specifically designed for patients with Down syndrome (DS) and acute myeloid leukemia (AML), and to determine the prognostic factors for event-free survival...
  70. ncbi request reprint Successful treatment with rituximab of refractory idiopathic thrombocytopenic purpura in a patient with Kabuki syndrome
    Yuka Torii
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Int J Hematol 90:174-6. 2009
    ..KS patients are often more susceptible to infection, so splenectomy should be avoided. Therefore, rituximab therapy is an alternative option for KS patients with ITP who fail to respond to first-line therapy...
  71. pmc Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia
    Yuki Konno
    Department of Pediatrics, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, Aomori 036 8562, Japan
    Haematologica 95:1293-9. 2010
    ..There have been no studies to determine the incidence of these mutations in Asian patients with Diamond-Blackfan anemia...
  72. ncbi request reprint Twenty years' experience in allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in the Nagoya Blood and Marrow Transplantation Group
    Hiroatsu Iida
    Department of Hematology, Meitetsu Hospital, Nagoya, Japan
    Int J Hematol 79:79-84. 2004
    ..Relapse is the major obstacle limiting the success of HSCT. Early transplantation during CR from donors, including unrelated persons or mismatched relatives, may offer improved long-term DFS...
  73. doi request reprint Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia
    Yoshiko Atsuta
    Department of Hematopoietic Stem Cell Transplantation Data Management, Nagoya University School of Medicine, Higashi ku Nagoya, Japan
    Blood 113:1631-8. 2009
    ..For patients with AML, decreasing mortality, especially in the early phase of transplantation, is required to improve the outcome for CB recipients...
  74. ncbi request reprint Mutations in telomerase catalytic protein in Japanese children with aplastic anemia
    Juan Liang
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haematologica 91:656-8. 2006
    ..This genetic difference does not explain the higher incidence of AA in Asian populations...
  75. doi request reprint Invasive fungal infections in pediatric patients with hematologic malignancies receiving oral amphotericin B solution and early intravenous administration of fluconazole
    Nobuhiro Watanabe
    Division of Hematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    J Pediatr Hematol Oncol 33:270-5. 2011
    ..Our results indicate that amphotericin B oral solution and early intravenous fluconazole may be effective in reducing the incidence and mortality of IFI in pediatric patients with hematologic malignancies...
  76. doi request reprint Carbohydrate and energy metabolism in the brain of rats with thromboxane A2-induced fetal growth restriction
    Masahiro Hayakawa
    Maternity and Perinatal Care Center, Nagoya University Hospital, Nagoya 466 8550, Japan
    Pediatr Res 70:21-4. 2011
    ..Gluconeogenesis compensated for chronic fetal hypoxia and decreased glycogen storage. Energy metabolism in the FGR brain is likely to be disrupted as a consequence of lower reserves of energy substrates...
  77. ncbi request reprint Diamond-Blackfan anemia in Japan: clinical outcomes of prednisolone therapy and hematopoietic stem cell transplantation
    Shouichi Ohga
    Department of Pediatrics, Kyushu University, Fukuoka, Japan
    Int J Hematol 79:22-30. 2004
    ..Two cord blood transplants from unrelated donors failed. These findings suggest the need for developing an integral treatment strategy including selective HSCT for refractory DBA...
  78. doi request reprint Concurrent Langerhans cell histiocytosis and nephroblastoma
    Ryoko Narui
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 52:662-4. 2009
    ..After complete resection of the nephroblastoma, she received standard chemoradiotherapy for nephroblastoma. She is alive without relapse 14 months after initial presentation...
  79. ncbi request reprint [Anemia in children]
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine
    Nihon Rinsho 66:544-7. 2008
    ..Delineation of the precise role of each gene product in ribosomal biogenesis and hematopoiesis may have both therapeutic and prognostic significance...
  80. ncbi request reprint Epstein-Barr virus-specific T-cell cytotoxicity is mediated through the perforin pathway in patients with lymphoproliferative disorders after allogeneic bone marrow transplantation
    Ayami Yoshimi
    The Department of Pediatrics Developmental Pediatrics, Nagoya University School of Medicine, Japan
    Br J Haematol 116:710-5. 2002
    ....
  81. doi request reprint Rotational speed control of Na +-driven flagellar motor by dual pipettes
    Kousuke Nogawa
    Japan Society for the Promotion of Science, Tokyo 102 8471, Japan
    IEEE Trans Nanobioscience 8:341-8. 2009
    ..It is shown that the rotational speed might be controllable by changing the spouting velocity of Na (+)-containing solution with multiplying the applied dc voltage...
  82. ncbi request reprint Nanoindentation methods to measure viscoelastic properties of single cells using sharp, flat, and buckling tips inside ESEM
    Mohd Ridzuan Ahmad
    Department of Micro Nano Systems Engineering, Nagoya University, Nagoya 464 8603, Japan
    IEEE Trans Nanobioscience 9:12-23. 2010
    ..Results from each of the tests show good agreement, from which strong conclusion can be drawn...
  83. doi request reprint Juvenile myelomonocytic leukemia: epidemiology, etiopathogenesis, diagnosis, and management considerations
    Ayami Yoshimi
    Department of HSCT Data Management, Nagoya University, Japan
    Paediatr Drugs 12:11-21. 2010
    ..Based on recent advances in the understanding of the pathogenesis of JMML, the development of novel targeted therapies, which might improve the outcome of patients, is keenly awaited...
  84. ncbi request reprint The MRI findings of the right-sided fetal lung can be used to predict postnatal mortality and the requirement for extracorporeal membrane oxygenation in isolated left-sided congenital diaphragmatic hernia
    Masahiro Hayakawa
    Maternity and Perinatal Care Center, Nagoya University Hospital, Nagoya, Aichi Prefecture, 466 8550 Japan
    Pediatr Res 62:93-7. 2007
    ..In isolated left-sided CDH, the %RFLV is a good predictor not only of postnatal mortality but also of the requirement for ECMO...
  85. pmc Characterization of the periplasmic domain of MotB and implications for its role in the stator assembly of the bacterial flagellar motor
    Seiji Kojima
    Dynamic NanoMachine Project, ICORP, JST, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Bacteriol 190:3314-22. 2008
    ..We propose that the MotB(C) dimer domain plays an important role in targeting and stable anchoring of the MotA/MotB complex to putative stator-binding sites of the motor...
  86. ncbi request reprint The effects of cell sizes, environmental conditions, and growth phases on the strength of individual W303 yeast cells inside ESEM
    Mohd Ridzuan Ahmad
    Department of Micro Nano Systems Engineering, Nagoya University, Nagoya 464 8603, Japan
    IEEE Trans Nanobioscience 7:185-93. 2008
    ..Finally, the penetration forces at different cell growth phases also show the increment pattern from log (early, mid, and late) to saturation phases, i.e., 161 +/- 25, 216 +/- 15, 255 +/- 21, and 408 +/- 41 nN, respectively...
  87. pmc Characterization of the periplasmic region of PomB, a Na+-driven flagellar stator protein in Vibrio alginolyticus
    Na Li
    Division of Microbiology, Graduate School of Life Science, Northwest A and F University, Yanglin, Japan
    J Bacteriol 193:3773-84. 2011
    ....
  88. ncbi request reprint Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors
    Tetsushi Yoshikawa
    Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, 4668550 Japan
    J Infect Dis 185:847-53. 2002
    ..031) for HHV-6 viremia. Rash occurring within 1 month after transplantation was observed in 17 (54.8%) of 31 recipients with HHV-6 viremia but in only 8 (19.5%) of 41 recipients without HHV-6 viremia (P=.001)...
  89. pmc Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay
    H Kimura
    Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Japan
    J Clin Microbiol 37:132-6. 1999
    ..842; P < 0.0001). These results indicate that the real-time PCR assay is useful for diagnosing symptomatic EBV infection and for monitoring the virus load...
  90. ncbi request reprint Expression of tegument protein pp65 of human cytomegalovirus (CMV) and its application to the analysis of viral-specific cellular immunity in CMV-infected individuals
    N Tanaka
    Department of Pediatrics, Developmental Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Arch Virol 147:2405-17. 2002
    ..The delay in re-constitution in CMV-specific cellular immunity was associated with reactivation of CMV. These results indicated that the recombinant protein pp65 can be used to study specific immunity in CMV infections...
  91. ncbi request reprint Chemotactic responses to an attractant and a repellent by the polar and lateral flagellar systems of Vibrio alginolyticus
    M Homma
    Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
    Microbiology 142:2777-83. 1996
    ..This may represent a functional difference between the two flagellar systems in Vibrio cells, and between the chemotaxis systems affecting the two types of flagella...
  92. ncbi request reprint Prospective monitoring of the Epstein-Barr virus DNA by a real-time quantitative polymerase chain reaction after allogenic stem cell transplantation
    Y Hoshino
    Department of Paediatrics Developmental Paediatrics, Nagoya University School of Medicine, Nagoya, Japan
    Br J Haematol 115:105-11. 2001
    ..We propose that an EBV load > 10(2.5) copies/microg DNA is the reactivation of EBV, and that an EBV load > 10(4.0) copies/microg DNA is indicative of developing LPD...
  93. ncbi request reprint Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group
    Eiichi Ishii
    Department of Pediatrics, Saga University, Nabeshima, Saga, Japan
    Pediatr Blood Cancer 47:268-72. 2006
    ..We analyzed the features and outcome of neonatal leukemia in Japan to establish an appropriate treatment strategy for this rare disorder...
  94. ncbi request reprint Leukemic cell death induced by antithymocyte globulin
    Ayami Yoshimi
    Department of Pediatrics Developmental Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Leuk Res 29:821-7. 2005
    ..Neither anti-Fas MoAb (ZB4) nor a broad caspase inhibitor (z-VAD FMK) prevented this increase in Annexin-V binding. These results suggest that ATG induces leukemic cell death in a Fas/Fas-ligand- and caspase-independent manner...
  95. doi request reprint Relationship between tacrolimus blood concentrations and clinical outcome during the first 4 weeks after SCT in children
    N Watanabe
    Division of Hematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Bone Marrow Transplant 45:1161-6. 2010
    ..Multivariate analysis showed that tacrolimus concentration was significantly associated with clinical outcomes. Mean whole-blood level of tacrolimus as continuous infusion should be maintained at > or =7 ng/ml for pediatric patients...
  96. ncbi request reprint Visualization of functional rotor proteins of the bacterial flagellar motor in the cell membrane
    Hajime Fukuoka
    Division of Biological Science, Graduate School of Biological Science, Nagoya University, Chikusa ku, Nagoya, 464 8602, Japan
    J Mol Biol 367:692-701. 2007
    ..Our results suggest that flagellar basal bodies diffuse in the cytoplasmic membrane until the axial structure and/or other structures assemble...
  97. ncbi request reprint Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in patients with chronic active EBV infection
    Naomi Sugaya
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Japan
    J Infect Dis 190:985-8. 2004
    ..Low frequencies of EBV-specific CD8+ T cells may be one of the immunological features of chronic active EBV infection...
  98. ncbi request reprint Correlation between HHV-6 infection and skin rash after allogeneic bone marrow transplantation
    T Yoshikawa
    Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 28:77-81. 2001
    ..3%) cases in group A, compared with none of 10 (0%) cases in group B (P = 0.001). Thus, this study suggests that HHV-6 may be involved in the development of skin rash in the first month after allogeneic BMT...
  99. doi request reprint Late-onset non-infectious pulmonary complications following allogeneic hematopoietic stem cell transplantation in children
    N Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 44:303-8. 2009
    ..0 vs 87.2%, P=0.000). Considering that we are lacking optimal therapies for LONIPCs, strategies aimed at the prevention of LONIPCs should be attempted...
  100. ncbi request reprint Risk factors for chronic graft-versus-host disease after allogeneic stem cell transplantation in children
    M Kondo
    Department of Pediatrics, Okazaki City Hospital, 3-1 Goshoai, Kuryuki-cho, Okazaki 444-8553, Japan
    Bone Marrow Transplant 27:727-30. 2001
    ..The high incidence associated with malignant disease may be affected by changes in GVHD prophylaxis in order to ensure graft-versus-tumor effects...
  101. ncbi request reprint Clinical and genetic analyses of presumed Shwachman-Diamond syndrome in Japan
    Hiromichi Taneichi
    Department of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan
    Int J Hematol 84:60-2. 2006
    ..In addition, presumed SDS patients without SBDS mutations may be included in other disorders...