Y Kodera

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc A randomized phase II trial to elucidate the efficacy of capecitabine plus cisplatin (XP) and S-1 plus cisplatin (SP) as a first-line treatment for advanced gastric cancer: XP ascertainment vs. SP randomized PII trial (XParTS II)
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, 241 0815, Yokohama, Asahi ku, Japan
    BMC Cancer 12:307. 2012
  2. ncbi request reprint Gastric cancer with minimal peritoneal metastasis: is this a sign to give up or to treat more aggressively?
    Yasuhiro Kodera
    Department of Surgery II Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nagoya J Med Sci 75:3-10. 2013
  3. doi request reprint Long-term follow up of patients who were positive for peritoneal lavage cytology: final report from the CCOG0301 study
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Gastric Cancer 15:335-7. 2012
  4. ncbi request reprint Chemotherapy as a component of multimodal therapy for gastric carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466 8550, Japan
    World J Gastroenterol 12:2000-5. 2006
  5. ncbi request reprint Gene expression of 5-fluorouracil metabolic enzymes in primary gastric cancer: correlation with drug sensitivity against 5-fluorouracil
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Cancer Lett 252:307-13. 2007
  6. ncbi request reprint Impact of clinical response to first-line chemotherapy on gastric cancer patients treated with second-line and third-line chemotherapy
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    Hepatogastroenterology 58:1041-5. 2011
  7. ncbi request reprint Intraperitoneal paclitaxel: a possible impact of regional delivery for prevention of peritoneal carcinomatosis in patients with gastric carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8580, Japan
    Hepatogastroenterology 54:960-3. 2007
  8. doi request reprint A randomized phase II trial to test the efficacy of intra-peritoneal paclitaxel for gastric cancer with high risk for the peritoneal metastasis (INPACT trial)
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 63 Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Clin Oncol 41:283-6. 2011
  9. ncbi request reprint Expression of L1 cell adhesion molecule is a significant prognostic factor in pT3-stage gastric cancer
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Anticancer Res 29:4033-9. 2009
  10. ncbi request reprint A phase II study of weekly paclitaxel as second-line chemotherapy for advanced gastric Cancer (CCOG0302 study)
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Anticancer Res 27:2667-71. 2007

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. pmc A randomized phase II trial to elucidate the efficacy of capecitabine plus cisplatin (XP) and S-1 plus cisplatin (SP) as a first-line treatment for advanced gastric cancer: XP ascertainment vs. SP randomized PII trial (XParTS II)
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, 241 0815, Yokohama, Asahi ku, Japan
    BMC Cancer 12:307. 2012
    ..However, the usefulness of XP as compared with S-1 plus cisplatin (SP), which is considered standard therapy in Japan, has not yet been assessed...
  2. ncbi request reprint Gastric cancer with minimal peritoneal metastasis: is this a sign to give up or to treat more aggressively?
    Yasuhiro Kodera
    Department of Surgery II Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nagoya J Med Sci 75:3-10. 2013
    ..Even in this category of patients, surgery in combination with various types of chemotherapy remains the only hope for a cure...
  3. doi request reprint Long-term follow up of patients who were positive for peritoneal lavage cytology: final report from the CCOG0301 study
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Gastric Cancer 15:335-7. 2012
    ..4 M gimestat-1 M otastat potassium). Forty-eight patients were enrolled, of whom 47 were found to have been eligible for analysis. The 2-year survival rate of 46 % exceeded our expectations...
  4. ncbi request reprint Chemotherapy as a component of multimodal therapy for gastric carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466 8550, Japan
    World J Gastroenterol 12:2000-5. 2006
    ....
  5. ncbi request reprint Gene expression of 5-fluorouracil metabolic enzymes in primary gastric cancer: correlation with drug sensitivity against 5-fluorouracil
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Cancer Lett 252:307-13. 2007
    ..219, p=0.0343). OPRT was considered to have a major impact on drug sensitivity, although not sufficiently so to enable prediction of 5FU sensitivity solely based on the mRNA expression of this enzyme...
  6. ncbi request reprint Impact of clinical response to first-line chemotherapy on gastric cancer patients treated with second-line and third-line chemotherapy
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    Hepatogastroenterology 58:1041-5. 2011
    ..Patients treated with chemotherapy in a single Japanese institution were analyzed to identify patients who benefit from higher lines of chemotherapy...
  7. ncbi request reprint Intraperitoneal paclitaxel: a possible impact of regional delivery for prevention of peritoneal carcinomatosis in patients with gastric carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8580, Japan
    Hepatogastroenterology 54:960-3. 2007
    ..Peritoneal carcinomatosis is a common pattern of failure among gastric cancer patients. Adequate postoperative adjuvant chemotherapy could reduce the risk of this lethal recurrence...
  8. doi request reprint A randomized phase II trial to test the efficacy of intra-peritoneal paclitaxel for gastric cancer with high risk for the peritoneal metastasis (INPACT trial)
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 63 Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Clin Oncol 41:283-6. 2011
    ..It is hoped that this trial will result in a breakthrough in the treatment of peritoneal carcinomatosis from gastric cancer...
  9. ncbi request reprint Expression of L1 cell adhesion molecule is a significant prognostic factor in pT3-stage gastric cancer
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Anticancer Res 29:4033-9. 2009
    ..L1, a 200-220 kDa transmembrane glycoprotein of the immunoglobulin superfamily, has been shown to affect prognosis of various types of cancer and was shown to enhance peritoneal metastasis in ovarian cancer in vivo...
  10. ncbi request reprint A phase II study of weekly paclitaxel as second-line chemotherapy for advanced gastric Cancer (CCOG0302 study)
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Anticancer Res 27:2667-71. 2007
    ..Although paclitaxel was given triweekly in phase II trials prior to its approval for gastric cancer in Japan, it is currently more often delivered by a weekly schedule in the second-line setting...
  11. ncbi request reprint Radical surgery for gastric carcinoma: it is not an issue of whether to perform D1 or D2. Dissect as many lymph nodes as possible and you will be rewarded
    E Kodera
    Department of Surgery II, Nagoya University School of Medicine, Showa, Nagoya, Aichi, Japan
    Acta Chir Belg 109:27-35. 2009
    ..Lymphadenectomy should no longer be considered only as a tool for cancer-staging, but also as a beneficial therapeutic measure...
  12. ncbi request reprint Follow-up surveillance for recurrence after curative gastric cancer surgery lacks survival benefit
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine, Aichi, Japan
    Ann Surg Oncol 10:898-902. 2003
    ..Although routine follow-up to detect asymptomatic recurrence after surgery for gastric cancer is recommended, the effect of such reassessment on survival has not been evaluated...
  13. ncbi request reprint Detection of disseminated cancer cells in linitis plastica-type gastric carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Jpn J Clin Oncol 34:525-31. 2004
    ..Reverse transcriptase polymerase chain reaction (RT-PCR) is a sensitive technique for detecting these cells...
  14. doi request reprint A phase II study of radical surgery followed by postoperative chemotherapy with S-1 for gastric carcinoma with free cancer cells in the peritoneal cavity (CCOG0301 study)
    Y Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Eur J Surg Oncol 35:1158-63. 2009
    ..A standard treatment for such patients remains to be established...
  15. doi request reprint The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya 466 8550, Aichi, Japan
    World J Surg 32:2015-20. 2008
    ..Although a prominent pattern of disease failure is peritoneal carcinomatosis, some patients experience rapid disease progression without signs of the peritoneal disease...
  16. ncbi request reprint Obesity and outcome of distal gastrectomy with D2 lymphadenectomy for carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine Nagoya, Aichi 466 8550, Japan
    Hepatogastroenterology 51:1225-8. 2004
    ..Obesity has correlated with surgical outcome in patients undergoing elective surgery for various cancers. This relationship has not been examined for gastric cancer surgery performed at a specialized high-volume center...
  17. ncbi request reprint In vitro chemosensitivity test to predict chemosensitivity for paclitaxel, using human gastric carcinoma tissues
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Clin Oncol 11:449-53. 2006
    ..Therapy guided by chemotherapy sensitivity and resistance assays may lead to rational treatment decisions. Paclitaxel, one of several new drugs for gastric carcinoma, has not been extensively evaluated by in vitro chemosensitivity tests...
  18. ncbi request reprint Identification of risk factors for the development of complications following extended and superextended lymphadenectomies for gastric cancer
    Y Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Centre, Nagoya, Japan
    Br J Surg 92:1103-9. 2005
    ..Extended lymphadenectomy for gastric carcinoma has been associated with high mortality and morbidity rates in several multicentre randomized trials...
  19. ncbi request reprint Combination of oral fluoropyrimidine and docetaxel: reappraisal of synergistic effect against gastric carcinoma xenografts
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466 8550, Japan
    In Vivo 19:861-6. 2005
    ..The synergistic antitumor effect of a combination of docetaxel and capecitabine is reported to be attributable to docetaxel-mediated up-regulation of thymidine phosphorylase (dThdPase)...
  20. ncbi request reprint Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients
    S Terakura
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Bone Marrow Transplant 37:381-6. 2006
    ..These results suggest that a GSTM1-null genotype in recipients protects against TRM after allogeneic HSCT. Further studies are needed to elucidate a mechanism of increased risk for TRM in GSTM1-positive recipients...
  21. ncbi request reprint Significance of additional high-dose cytarabine in combination with cyclophosphamide plus total body irradiation regimen for allogeneic stem cell transplantation
    Y Inamoto
    Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Bone Marrow Transplant 39:25-30. 2007
    ..In summary, addition of HDCA is not beneficial for high-risk patients, and is not recommended for standard-risk patients receiving unrelated transplantation...
  22. ncbi request reprint Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation
    Y Atsuta
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Japan
    Bone Marrow Transplant 37:289-96. 2006
    ..Our patients could not be accurately classified when the proposed prognostic models from Western countries were used, thus indicating the need for a different model to identify high-risk patients...
  23. ncbi request reprint Peritoneal washing cytology: prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection
    Y Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Japan
    J Surg Oncol 72:60-4; discussion 64-5. 1999
    ..Free cancer cells in the abdominal cavity exfoliated from a tumor are considered to be responsible for peritoneal dissemination, the most frequent pattern of failure in gastric carcinoma patients treated with curative surgery...
  24. pmc Prospective validation of quantitative CEA mRNA detection in peritoneal washes in gastric carcinoma patients
    S Ito
    1Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Br J Cancer 93:986-92. 2005
    ..0130) and peritoneal recurrence-free survival (P=0.0006) as end points. These results indicate that quantitation of CEA mRNA in peritoneal washes is a reliable prognostic indicator of peritoneal recurrence in the clinical setting...
  25. ncbi request reprint Primary gastric B cell lymphoma: audit of 82 cases treated with surgery and classified according to the concept of mucosa-associated lymphoid tissue lymphoma
    Y Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Center, Japan
    World J Surg 24:857-62. 2000
    ..Investigators are advised to note that the histopathologic grade determined with biopsy specimens alone could be misleading...
  26. ncbi request reprint Is Borrmann type IV gastric carcinoma a surgical disease? An old problem revisited with reference to the result of peritoneal washing cytology
    Y Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Aichi, Japan
    J Surg Oncol 78:175-81; discussion 181-2. 2001
    ..Cytology examination of the peritoneal washes is an established prognostic factor for gastric carcinoma in general, and may be useful for identifying adequate treatment strategy for B-4...
  27. ncbi request reprint Lymph node metastasis in cancer of the middle-third stomach: criteria for treatment with a pylorus-preserving gastrectomy
    Y Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Japan
    Surg Today 31:196-203. 2001
    ....
  28. doi request reprint Value of peritoneal cytology in potentially resectable pancreatic cancer
    S Yamada
    Department of Gastroenterological Surgery Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Surg 100:1791-6. 2013
    ..Peritoneal lavage cytology (CY) is used in the diagnosis and staging of various cancers. The clinical significance of positive cytology results in patients with pancreatic cancer is yet to be determined...
  29. doi request reprint Antitumor efficacy of oncolytic herpes simplex virus adsorbed onto antigen-specific lymphocytes
    A Kanzaki
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Gene Ther 19:292-8. 2012
    ..In this context, herpes oncolytic virus is a promising treatment not only for primary lesions, but also for multiple metastasizing lesions. This treatment strategy may become one of the most effective methods for systemic virus delivery...
  30. doi request reprint Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic SCT
    M Murase
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Bone Marrow Transplant 46:1444-9. 2011
    ..As the presence of the C-A-A haplotype reduced relapse risk and improved survival after allogeneic HSCT, this CTLA-4 haplotype may provide useful information for donor selection...
  31. ncbi request reprint Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy
    T Naoe
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Leukemia 16:203-8. 2002
    ..073; within 120 days, P = 0.028), whereas CR rates and relapse frequencies were similar. The null genotype of GSTT1 might be associated with increased toxicity after chemotherapy...
  32. ncbi request reprint PAI-1 expression levels in esophageal and colorectal cancers are closely correlated to those in corresponding normal tissues
    T Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:4343-7. 2006
    ..Taken together, PAI-1 overexpression in esophageal and colorectal cancers might originate from higher PAI-1 expression in corresponding normal tissues and result in a malignant phenotype of these cancers...
  33. pmc Methylation pattern of CDH13 gene in digestive tract cancers
    K Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Br J Cancer 91:1139-42. 2004
    ..These results suggested that CDH13 might play a variety of roles depending on the tissue type...
  34. ncbi request reprint Enhanced efficacy of herpes simplex virus mutant HF10 combined with paclitaxel in peritoneal cancer dissemination models
    S Shimoyama
    Department of Surgery II, Graduate School of Medicine Nagoya University, Nagoya, Japan
    Hepatogastroenterology 54:1038-42. 2007
    ..Further, we attempted to evaluate HF10/paclitaxel combination therapy...
  35. doi request reprint Phase II clinical trial of postoperative S-1 monotherapy for gastric cancer patients with free intraperitoneal cancer cells detected by real-time RT-PCR
    Seiji Ito
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    World J Surg 34:2083-9. 2010
    ..Patients with CEA mRNA exceeding a cutoff value have a significant risk for developing peritoneal carcinomatosis, but optimal treatment for this population remains unknown...
  36. pmc Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
    T Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Japan
    Br J Cancer 93:799-803. 2005
    ..0432). These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC...
  37. ncbi request reprint Molecular diagnostic detection of free cancer cells in the peritoneal cavity of patients with gastrointestinal and gynecologic malignancies
    H Nakanishi
    Laboratory of Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Chemother Pharmacol 43:S32-6. 1999
    ..Highly sensitive and rapid detection of free cancer cells in peritoneal washes, most reliably by RT-PCR, is a powerful technique to predict peritoneal dissemination in patients with gastric and ovarian cancers...
  38. doi request reprint Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD
    Y Inamoto
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 45:363-9. 2010
    ..In conclusion, more active homing of CCR9-926AG T cells to Peyer's patches may produce changes in Ag presentation and result in increased incidence of skin GVHD...
  39. ncbi request reprint Use of a segment of transverse colon as a gastric substitute after total gastrectomy: an audit of 18 patients
    Y Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Center, Kanokoden, Nagoya, Aichi 464-8681, Japan
    Gastric Cancer 4:60-5. 2001
    ..CONCLUSION: Although it may be too early to draw definite conclusions, there seems to be little benefit in the use of the transverse colon as a gastric substitute...
  40. ncbi request reprint Prognostic significance of intraperitoneal cancer cells in gastric carcinoma: detection of cytokeratin 20 mRNA in peritoneal washes, in addition to detection of carcinoembryonic antigen
    Yasuhiro Kodera
    Second Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gastric Cancer 8:142-8. 2005
    ..A search for other molecular markers is ongoing...
  41. ncbi request reprint Small incisional esophagectomy with endoscopic assistance: evaluation of a new technique
    S Akiyama
    Department of Surgery II, Nagoya University School of Medicine, Aichi, Japan
    Surg Today 31:378-82. 2001
    ..The postoperative courses of 20 consecutive patients who underwent this procedure were generally uneventful, and significant improvements in terms of intensive care and analgesic requirements were observed...
  42. doi request reprint Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma
    M Hayashi
    Department of Surgery II, Graduate School of Medicine, University of Nagoya, Showa Ku, Nagoya, Japan
    J Surg Oncol 105:381-6. 2012
    ..Hepatocellular carcinoma (HCC) is a major health problem, and identification of new tumor-related genes is an urgent task...
  43. ncbi request reprint Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: significant roles of total body irradiation and chronic graft-versus-host disease
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Bone Marrow Transplant 36:867-72. 2005
    ..Thus, patients who developed extensive chronic GVHD had better survivals (P = 0.0217), and those who developed grade III-IV acute GVHD had worse survivals (P = 0.0023) than did the others...
  44. ncbi request reprint The human cathepsin H gene encodes two novel minor histocompatibility antigen epitopes restricted by HLA-A*3101 and -A*3303
    H Torikai
    Division of Immunology, Aichi Cancer Centre Research Institute, Nagoya, Japan
    Br J Haematol 134:406-16. 2006
    ..Although the mechanisms involved in the differential susceptibility remain to be determined, these data suggest that CTSH-encoded mHags could be targets for GVL effects...
  45. ncbi request reprint Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis
    K Shimada
    Nagoya Blood and Marrow Transplantation Group NBMTG, Nagoya, Japan
    Bone Marrow Transplant 36:115-21. 2005
    ..8%. Our data suggest that early detection of secondary cancers is very important in prolonging overall survival...
  46. ncbi request reprint Preoperative embolization therapy for esophageal operation
    S Akiyama
    Department of Surgery II, Nagoya University School of Medicine, Japan
    J Surg Oncol 69:219-23. 1998
    ..The clinical effects and complications associated with PET are reported...
  47. ncbi request reprint Plasminogen activator inhibitor-1 as a potential marker for the malignancy of esophageal squamous cell carcinoma
    Takumi Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Cancer Res 10:1375-8. 2004
    ....
  48. ncbi request reprint Longterm outcomes of early-stage gastric carcinoma patients treated with laparoscopy-assisted surgery
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Coll Surg 206:138-43. 2008
    ..Laparoscopy-assisted approaches have become popular for dissecting early-stage gastric cancer in Japan, but the outcomes after 5 years of followup have not been reported...
  49. ncbi request reprint Efficacy of intraperitoneal chemotherapy with paclitaxel targeting peritoneal micrometastasis as revealed by GFP-tagged human gastric cancer cell lines in nude mice
    Norifumi Ohashi
    Department of Surgery II, Nagoya University School of Medicine, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Oncol 27:637-44. 2005
    ..These results indicate that intraperitoneal paclitaxel is effective against peritoneal metastasis in early phase...
  50. doi request reprint Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer
    T T Sahin
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Gene Ther 19:229-37. 2012
    ..HF10 seems to meet this criterion; furthermore, it induces potent antitumor immunity. The increase in angiogenesis may be due to either viral replication or the inflammatory response...
  51. pmc Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation
    Y Kodera
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Br J Cancer 68:130-6. 1993
    ..Further analysis revealed significant up-regulation of NCA in well and moderately differentiated gastric cancers over poorly differentiated cancers, suggesting that NCA might have roles in differentiation...
  52. ncbi request reprint Hematopoietic stem cell transplantation for natural killer-cell lineage neoplasms
    R Suzuki
    Division of Molecular Medicine, Aichi Cancer Center, Kanokoden, Nagoya, Japan
    Bone Marrow Transplant 37:425-31. 2006
    ..03). These findings suggest that the HSCT is a promising treatment strategy for NK-cell lineage...
  53. pmc CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer
    K Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Br J Cancer 90:1030-3. 2004
    ....
  54. ncbi request reprint Gene expression profile of 5-fluorouracil metabolic enzymes in primary colorectal cancer: potential as predictive parameters for response to fluorouracil-based chemotherapy
    Mizunobu Kinoshita
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Anticancer Res 27:851-6. 2007
    ..Therapy guided by chemotherapy sensitivity and resistance assays may lead to rational treatment decisions...
  55. ncbi request reprint The effect of chemotherapy against micrometastases and isolated tumor cells in lymph nodes: an in vivo study
    Takehiko Eguchi
    Department of Surgery II, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    In Vivo 22:707-12. 2008
    ..An in vivo model was established in which a gastric cancer cell line, GCIY-EGFP, metastasizes spontaneously to the lymph nodes when inoculated subcutaneously...
  56. ncbi request reprint TNF-alpha promotes progression of peritoneal metastasis as demonstrated using a green fluorescence protein (GFP)-tagged human gastric cancer cell line
    Yoshinari Mochizuki
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Exp Metastasis 21:39-47. 2004
    ....
  57. ncbi request reprint Biological significance of isolated tumor cells and micrometastasis in lymph nodes evaluated using a green fluorescent protein-tagged human gastric cancer cell line
    Hiroyuki Yokoyama
    Department of Surgery II, Nagoya University School of Medicine and Division of Oncological Pathology, Aichi Cancer Center Research Institute, Kanokoden, Chukisa ku, 464 8681 Nagoya, Japan
    Clin Cancer Res 12:361-8. 2006
    ..Using this model, we investigated the effect of surgery and chemotherapy on the growth of early-phase metastasis formation in the lymph nodes...
  58. ncbi request reprint Prognostic significance of intraperitoneal cancer cells in gastric carcinoma: analysis of real time reverse transcriptase-polymerase chain reaction after 5 years of followup
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Coll Surg 202:231-6. 2006
    ..A reverse transcriptase-polymerase chain reaction (RT-PCR) technique amplifying carcinoembryonic antigen mRNA was recently introduced to detect these cells more sensitively...
  59. ncbi request reprint Survival after curative resection for mucinous adenocarcinoma of the colorectum
    Yukihide Kanemitsu
    Department of Gastroenterological Surgery, The Aichi Cancer Center, Kanokoden, Nagoya, Japan
    Dis Colon Rectum 46:160-7. 2003
    ..The purpose of this study was to clarify whether the mucin-producing histologic type of carcinoma is associated with a worse prognosis than nonmucinous, differentiated colorectal adenocarcinoma for patients who undergo curative surgery...
  60. ncbi request reprint [Clinical significance of isolated tumor cells and micrometastases in patients with gastric carcinoma]
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gan To Kagaku Ryoho 34:817-23. 2007
    ..In this review,the authors describe the relevance of micrometastases detected in various body components of patients with gastric cancer, and propose how the information thus obtained could be reflected in the treatment strategy...
  61. ncbi request reprint S100A2 overexpression is frequently observed in esophageal squamous cell carcinoma
    Masahiko Imazawa
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Anticancer Res 25:1247-50. 2005
    ..We identified S100A2, a Ca2+-binding protein, as a novel downstream mediator of deltaNp63...
  62. ncbi request reprint Extended lymph node dissection in gastric carcinoma: where do we stand after the Dutch and British randomized trials?
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    J Am Coll Surg 195:855-64. 2002
  63. ncbi request reprint Aberrant methylation of the CHFR gene in digestive tract cancer
    Yuki Morioka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:1791-5. 2006
    ..Recently, aberrant methylation of the CHFR gene associated with gene silencing has been reported in several cancers. The methylation status of the CHFR gene was examined in primary esophageal and gastric carcinomas...
  64. ncbi request reprint Influence of habitual smoking on gastric cancer by histologic subtype
    M Inoue
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 81:39-43. 1999
    ..Risk patterns were less clear in females. Our results suggest that habitual smoking is associated more likely with the differentiated type of gastric cancer, particularly in younger cases...
  65. ncbi request reprint A small deletion in the 3'-untranslated region of the cyclin D1/PRAD1/bcl-1 oncogene in a patient with chronic lymphocytic leukemia
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Research Institute, Nagoya, Japan
    Int J Cancer 76:791-6. 1998
    ....
  66. doi request reprint Eosinophilia predicts better overall survival after acute graft-versus-host-disease
    N Imahashi
    Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Bone Marrow Transplant 45:371-7. 2010
    ..In conclusion, eosinophilia was associated with milder acute GVHD and better prognosis among patients with acute GVHD. The pathophysiology behind eosinophilia after allogeneic HSCT remains to be investigated...
  67. ncbi request reprint Plasminogen activator inhibitor-1 as a potential marker for the malignancy of gastric cancer
    Takumi Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Cancer Sci 97:395-9. 2006
    ..0450). These results suggested that PAI-1 might serve as a new and promising parameter for the prediction of prognosis in gastric cancer...
  68. ncbi request reprint Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer
    Masayasu Hara
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi, 464 8681, Japan
    Clin Exp Metastasis 24:179-89. 2007
    ....
  69. doi request reprint Pancreatic cancer with paraaortic lymph node metastasis: a contraindication for radical surgery?
    Suguru Yamada
    Department of Surgery II, Graduate School and Faculty of Medicine, University of Nagoya, Nagoya, Japan
    Pancreas 38:e13-7. 2009
    ..The purpose of this study was to determine the operative indications for pancreatic cancer with paraaortic lymph node metastases (No. 16 [+])...
  70. ncbi request reprint PAI-1 expression levels in gastric cancers are closely correlated to those in corresponding normal tissues
    Takumi Sakakibara
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tusrumai cho, Showa Ku, Nagoya 466 8560, Japan
    Hepatogastroenterology 55:1480-3. 2008
    ..To investigate the mechanism of PAI-1 overexpression in gastric cancers, the PAI-1 expression levels in gastric cancers were compared to those in the corresponding normal tissues...
  71. ncbi request reprint Para-aortic lymph node metastasis in carcinoma of the head of the pancreas
    Mitsuru Sakai
    Department of Surgery II, Nagoya University School of Medicine, Showa Ku, Nagoya, Japan
    Surgery 137:606-11. 2005
    ..Metastasis to para-aortic lymph nodes often occurs in pancreatic head cancer, but factors that predict it are not well known...
  72. ncbi request reprint Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients
    Shinichi Fujitake
    Gastrointestinal Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol 39:120-4. 2004
    ..To define the role of SOCS-1 in the tumorigenic pathway of the colorectum, we examined the methylation of SOCS-1 in tumors of colorectal cancer patients...
  73. pmc Quantitative detection of disseminated free cancer cells in peritoneal washes with real-time reverse transcriptase-polymerase chain reaction: a sensitive predictor of outcome for patients with gastric carcinoma
    Yasuhiro Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya Aichi, Japan
    Ann Surg 235:499-506. 2002
    ..To evaluate the feasibility of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) detection of free cancer cells in the peritoneal washes as a prognostic indicator for patients with gastric carcinoma...
  74. ncbi request reprint Detection of p16 promoter hypermethylation in serum of gastric cancer patients
    Yasuaki Kanyama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Cancer Sci 94:418-20. 2003
    ..No methylation was found in serum DNA of these control groups. Our results suggest that p16 methylation would be a good marker for the detection of tumor DNA in the serum of primary gastric cancer patients...
  75. ncbi request reprint Telomerase activity as prognostic factor in gastrointestinal stromal tumors of the stomach
    Jun Kawai
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya University Hospital, Nagoya, Japan
    Hepatogastroenterology 52:959-64. 2005
    ..Telomerase activity, often detected in malignant tumors, may have a role as a marker for high-grade malignancy...
  76. doi request reprint Nutritional predictors of postoperative outcome in pancreatic cancer
    M Kanda
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Br J Surg 98:268-74. 2011
    ..Nutritional status plays an important role in the incidence of postoperative complications and the prognosis of various tumours. The prognostic value of preoperative nutritional factors in patients with pancreatic cancer is not known...
  77. doi request reprint A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer
    A Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Gene Ther 18:167-75. 2011
    ..The tumors were classified as stable disease in three patients, partial response in one patient and progressive disease in two patients...
  78. ncbi request reprint Quantitative detection of disseminated cancer cells in the greater omentum of gastric carcinoma patients with real-time RT-PCR: a comparison with peritoneal lavage cytology
    Yasuhiro Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Gastric Cancer 5:69-76. 2002
    ..It may be beneficial to explore, by the same method, a sample of the omentum, which is known to harbor cancer cells before the establishment of gross peritoneal metastasis...
  79. ncbi request reprint PTCH gene expression as a potential marker for esophageal squamous cell carcinoma
    Akiharu Ishiyama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:195-8. 2006
    ..The PTCH expression level in esophageal squamous cell carcinoma (SCC) was examined...
  80. ncbi request reprint Distribution of free cancer cells in the abdominal cavity suggests limitations of bursectomy as an essential component of radical surgery for gastric carcinoma
    Yoshitaka Yamamura
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Gastric Cancer 10:24-8. 2007
    ..However, no evidence to support the prognostic significance of this procedure has been reported to date...
  81. ncbi request reprint Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer
    Tamotsu Inoue
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8560, Japan
    J Gastroenterol 40:143-7. 2005
    ..To avoid unnecessary medication and uncomfortable side effects, it is important to estimate the chemosensitivity of cancers to 5-fluorouracil (5-FU) before chemotherapy...
  82. ncbi request reprint RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer
    Yasuhiro Imamura
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 25:2627-30. 2005
    ..In this study, we investigated the methylation status of the RUNX3 gene in 92 resected primary colorectal cancers using methylation-specific PCR (MSP) and correlated the results with the clinicopathological features of affected patients...
  83. ncbi request reprint Laparoscopy-assisted distal gastrectomy with systemic lymph node dissection: a phase II study following the learning curve
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University School of Medicine, Nagoya Aichi, Japan
    J Surg Oncol 91:26-32. 2005
    ..A preliminary study on the use of laparoscopy-assisted approach to treat gastric carcinoma resulted in higher morbidity...
  84. ncbi request reprint Laparoscopy-assisted distal gastrectomy with systemic lymph node dissection for early gastric carcinoma: a review of 43 cases
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University School of Medicine, Nagoya Aichi, Japan
    J Am Coll Surg 196:75-81. 2003
    ..But the use of this approach in gastric carcinoma has received little attention, possibly from the low incidence of early-stage disease in the West and the relative complexity of the surgical procedure...
  85. ncbi request reprint TAOS1, a novel marker for advanced esophageal squamous cell carcinoma
    Yoshinao Komatsu
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:2029-32. 2006
    ..TAOS1 (tumor amplified and overexpressed sequence 1) was recently cloned and found to be possibly important in driving the amplification of 11q13 in oral squamous cell carcinoma (SCC)...
  86. doi request reprint The Japan Marrow Donor Program, the Japan Cord Blood Bank Network and the Asia Blood and Marrow Transplant Registry
    Y Kodera
    Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University, Aichi, Japan
    Bone Marrow Transplant 42:S6. 2008
    ..Globalization of patient and donor registration for HSCT has become realistic and this could contribute to both the further improvement of patient outcomes and to further donor safety...
  87. ncbi request reprint Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach
    T Mizoshita
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Gastric Cancer 4:185-91. 2001
    ..The aims of this study were: (1) to assess the normal tissue expression patterns of Cdx1 and Cdx2 in the human gastrointestinal tract and (2) to ascertain levels in intestinal metaplasia (IM) of the stomach associated with gastritis...
  88. doi request reprint Assessment of quality of life after gastrectomy using EORTC QLQ-C30 and STO22
    Daisuke Kobayashi
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    World J Surg 35:357-64. 2011
    ..The aim of this study was to evaluate the HRQOL after gastrectomy using these instruments and to compare various aspects of HRQOL among surgical procedures...
  89. ncbi request reprint Laparoscopy-assisted distal gastrectomy with systemic lymph node dissection: a critical reappraisal from the viewpoint of lymph node retrieval
    Shinichi Miura
    Department of Surgery II, Nagoya University School of Medicine, Nagoya Aichi, Japan
    J Am Coll Surg 198:933-8. 2004
    ..Laparoscopy-assisted surgery has proved useful in the treatment of early gastric cancer, but its use in advanced cancer may be hindered by limitations in lymphadenectomy...
  90. ncbi request reprint Quantitative detection of CEA expressing free tumor cells in the peripheral blood of colorectal cancer patients during surgery with real-time RT-PCR on a LightCycler
    Seiji Ito
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Aichi, 464 8681, Nagoya, Japan
    Cancer Lett 183:195-203. 2002
    ..Real-time quantitative RT-PCR is a useful technique for quantitative assessment of free tumor cells in the peripheral blood of colorectal cancer patients...
  91. doi request reprint Amylase concentration of the drainage fluid as a risk factor for intra-abdominal abscess following gastrectomy for gastric cancer
    Naoki Iwata
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    World J Surg 34:1534-9. 2010
    ..Amylase concentration of the drainage fluid following total gastrectomy for gastric cancer has been reported to be a useful risk factor for surgical complications...
  92. ncbi request reprint Determining prognostic factors for gastric cancer using the regression tree method
    Yoshitaka Yamamura
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Gastric Cancer 5:201-7. 2002
    ..The regression tree method is a useful statistical technique that has been little used in the analysis of prognosis...
  93. doi request reprint Prognostic impact of pancreatic margin status in the intraductal papillary mucinous neoplasms of the pancreas
    Tsutomu Fujii
    Department of Surgery II, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Surgery 148:285-90. 2010
    ..Intraductal papillary mucinous neoplasm (IPMN) of the pancreas often recurs after operative resection. The absolute risk and incidence of recurrence, however, especially in the remnant pancreas, is unknown...
  94. doi request reprint Construct validity of the LapVR virtual-reality surgical simulator
    Naoki Iwata
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Surg Endosc 25:423-8. 2011
    ..The aim of the current study is to show construct validity of a novel simulator, LapVR (Immersion Medical, San Jose, CA, USA), for Japanese surgeons and surgical residents...
  95. ncbi request reprint Methylation pattern of HLTF gene in digestive tract cancers
    Kenji Hibi
    Gastroenterological Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Int J Cancer 104:433-6. 2003
    ..These results suggested that HLTF might play a variety of roles depending on the tissue type and could be inactivated at an early stage in the tumorigenic pathway...
  96. doi request reprint Multivariate analysis of the pathologic features of esophageal squamous cell cancer: tumor budding is a significant independent prognostic factor
    Masahiko Koike
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Ann Surg Oncol 15:1977-82. 2008
    ..Tumor budding has been suggested to be a prognostic factor in various cancers but has never been studied in esophageal cancer...
  97. ncbi request reprint Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Dis Colon Rectum 48:1282-6. 2005
    ....
  98. ncbi request reprint Breast carcinoma metastasis to the esophagus: report of two cases
    Masahiko Koike
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Hepatogastroenterology 52:1116-8. 2005
    ..Esophageal metastasis from breast carcinoma is rare, but does occur. Often presenting long after initial therapy, an aggressive approach may be justified if this is a solitary lesion...
  99. ncbi request reprint Aberrant methylation of the CHFR gene is frequently detected in non-invasive colorectal cancer
    Yuki Morioka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 26:4267-70. 2006
    ..In order to define the role of CHFR in the tumorigenic pathway of the colorectum, the methylation of CHFR was examined in tumors from colorectal cancer patients...
  100. ncbi request reprint Oncological problems in pancreatic cancer surgery
    Akimasa Nakao
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    World J Gastroenterol 12:4466-72. 2006
    ..Recent molecular-biological studies have clarified occult metastasis, micrometastasis and systemic disease in pancreatic cancer. Several oncological problems in pancreatic cancer surgery are discussed in the present review...
  101. ncbi request reprint A highly sensitive method for the detection of p16 methylation in the serum of colorectal cancer patients
    Goro Nakayama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 27:1459-63. 2007
    ..An attempt to increase the sensitivity of this assay is reported for colorectal cancer...