Affiliation: Nagoya University
Kawashima N, Akashi A, Nagata Y, Kihara R, Ishikawa Y, Asou N, et al
. Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study. Ann Hematol. 2018;: pubmed publisher
..Further analysis is required to clarify the detailed biological mechanism of AE9a regulation of the cohesin complex. ..
Kiyoi H, Naoe T. Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation. Int J Hematol. 2006;83:301-8 pubmed
Nishiyama T, Ishikawa Y, Kawashima N, Akashi A, Adachi Y, Hattori H, et al
. Mutation analysis of therapy-related myeloid neoplasms. Cancer Genet. 2018;222-223:38-45 pubmed publisher
Sakai K, Ishikawa Y, Mori Y, Kobayashi M, Iriyama C, Ozawa Y, et al
. A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis. Int J Hematol. 2011;93:237-242 pubmed publisher
..Cytogenetic and immunoglobulin heavy chain gene rearrangement analysis revealed that all mutant clones that appeared in this patient might be derived from the same CML clone. ..
Harada Y, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, et al
. Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study. Leuk Res. 2018;66:20-27 pubmed publisher
..As many molecular targeting agents, such as FLT3 inhibitors, have been developed, we must continue to modify the genetic risk stratification system to match the progression of therapeutic strategies. ..
Shirahata Adachi M, Iriyama C, Tomita A, Suzuki Y, Shimada K, Kiyoi H. Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome. Leuk Res. 2017;63:90-97 pubmed publisher
..Our findings suggest that the loss of function of EZH2 induced by aberrant splicing, and/or EZH2 mutations resulting in the production of C-terminally truncated proteins, may be involved in MDS pathogenesis. ..