H Kiyoi

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint FLT3 in human hematologic malignancies
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Leuk Lymphoma 43:1541-7. 2002
  2. ncbi request reprint A xeno-transplantable plasma cell leukemia line with a split translocation of the IgH gene
    Kaneyuki Ohbayashi
    Department of Infectious Diseases, Nagoya University School of Medicine, 466 8560, Nagoya, Japan
    Cancer Genet Cytogenet 144:31-5. 2003
  3. ncbi request reprint Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line
    M Ninomiya
    Department of Hematology, Nagoya University Hospital, Nagoya, Japan
    Leukemia 18:442-8. 2004
  4. ncbi request reprint [Infection control in neutropenia induced by high-dose cytarabine chemotherapy]
    Masayuki Miyazaki
    Dept of Pharmacology, Kyoto Pharmaceutical University
    Gan To Kagaku Ryoho 31:2011-5. 2004
  5. ncbi request reprint Normal and oncogenic FLT3
    T Naoe
    Department of Hematology, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cell Mol Life Sci 61:2932-8. 2004
  6. ncbi request reprint Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Oncogene 21:2555-63. 2002
  7. ncbi request reprint Clinical significance of FLT3 in leukemia
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Japan
    Int J Hematol 82:85-92. 2005
  8. ncbi request reprint Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 83:301-8. 2006
  9. ncbi request reprint Immunoglobulin variable region structure and B-cell malignancies
    H Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Int J Hematol 73:47-53. 2001
  10. ncbi request reprint A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Clin Cancer Res 13:4575-82. 2007

Collaborators

Detail Information

Publications63

  1. ncbi request reprint FLT3 in human hematologic malignancies
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Leuk Lymphoma 43:1541-7. 2002
    ..In this review, we summarize the clinical and biological significance of FLT3-mutations and discuss the possibility of targeting FLT3 kinase for the treatment of leukemia...
  2. ncbi request reprint A xeno-transplantable plasma cell leukemia line with a split translocation of the IgH gene
    Kaneyuki Ohbayashi
    Department of Infectious Diseases, Nagoya University School of Medicine, 466 8560, Nagoya, Japan
    Cancer Genet Cytogenet 144:31-5. 2003
    ..Injection of SACHI cells into NOD/SCID mice generated leukemic plasmacytosis with invasion to liver, spleen, and bone marrow. This cell line may be useful for therapeutic testing as well as analyzing the molecular pathogenesis of PCL...
  3. ncbi request reprint Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line
    M Ninomiya
    Department of Hematology, Nagoya University Hospital, Nagoya, Japan
    Leukemia 18:442-8. 2004
    ..These findings suggested that the activation of adhesion molecules for leukocytes and expression of CXC chemokines in the lung are closely involved in triggering RAS...
  4. ncbi request reprint [Infection control in neutropenia induced by high-dose cytarabine chemotherapy]
    Masayuki Miyazaki
    Dept of Pharmacology, Kyoto Pharmaceutical University
    Gan To Kagaku Ryoho 31:2011-5. 2004
    ..05). These results suggest that HDAC chemotherapy increased the infection risk compared to SDAC, and especially patients who received HDAC need a further prevention plan against gram-positive bacteria...
  5. ncbi request reprint Normal and oncogenic FLT3
    T Naoe
    Department of Hematology, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cell Mol Life Sci 61:2932-8. 2004
    ..Exploring the mechanism by which FLT3 mutations cause autoactivation and uncontrolled signaling might lead to a better understanding of how FLT3 becomes oncogenic and provide insights for the development of new drugs...
  6. ncbi request reprint Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Oncogene 21:2555-63. 2002
    ..These findings indicate that the FLT3 JM domain plays an important role in receptor activation, and that the length-mutated JM domain induces ligand-independent receptor activation but also activates Wt-FLT3 in a trans-manner...
  7. ncbi request reprint Clinical significance of FLT3 in leukemia
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Japan
    Int J Hematol 82:85-92. 2005
    ..Routine screening of FLT3 mutations is recommended to stratify the patients into distinct risk groups, while the optimal treatment strategy for patients with FLT3 mutations should be further evaluated...
  8. ncbi request reprint Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 83:301-8. 2006
    ....
  9. ncbi request reprint Immunoglobulin variable region structure and B-cell malignancies
    H Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Int J Hematol 73:47-53. 2001
    ..As the complete nucleotide sequences of the human Ig heavy and Ig light V region loci have now been determined, the study of Ig genetics has entered into the super-information era...
  10. ncbi request reprint A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Clin Cancer Res 13:4575-82. 2007
    ..The aim of this study was to evaluate the antileukemia activity of a novel FLT3 kinase inhibitor, FI-700...
  11. ncbi request reprint Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD
    M Okamoto
    1Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leukemia 21:403-10. 2007
    ..These results demonstrate that Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD...
  12. ncbi request reprint Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors
    Y Minami
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Leukemia 16:1535-40. 2002
    ..These findings imply that targeting of Hsp90 will facilitate the development of anti-TDFLT3 therapy, and that Hsp90 is closely involved in the oncogenic activation of FLT3...
  13. ncbi request reprint Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy
    T Naoe
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Leukemia 16:203-8. 2002
    ..073; within 120 days, P = 0.028), whereas CR rates and relapse frequencies were similar. The null genotype of GSTT1 might be associated with increased toxicity after chemotherapy...
  14. ncbi request reprint Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    Y Yamamoto
    Department of Infectious Diseases and the First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Blood 97:2434-9. 2001
    ..These results demonstrate that the FLT3 gene is the target most frequently mutated to become constitutively active in AML...
  15. doi request reprint BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4
    Momoko Suzuki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Eur J Haematol 84:229-38. 2010
    ..We investigated the mechanism responsible for imatinib (IM) resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) cell lines...
  16. ncbi request reprint Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice
    M Ninomiya
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Japan
    Leukemia 21:136-42. 2007
    ..These findings suggest that xenotransplantation into immunodeficient mice provides a useful model to study the leukemia niche...
  17. ncbi request reprint Leukemia relapse reconsidered from the molecular aspect
    T Naoe
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya 466 8560, Japan
    Leuk Lymphoma 37:527-34. 2000
    ..Studies on leukemia relapse have thus served as a model of clonal progression, which can be serially observed, including selection by chemotherapy, induction of resistant phenotype, and genetic alteration...
  18. doi request reprint Prognostic implication and biological roles of RhoH in acute myeloid leukaemia
    Toshihiro Iwasaki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 81:454-60. 2008
    ..e. high GTP-Rac) contributes to chemotherapy resistance in leukaemia cells. Our result suggests that inhibition of Rac and its signalling components might provide a useful anti-leukaemic strategy...
  19. ncbi request reprint Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leukemia 19:1345-9. 2005
    ..Although it should be borne in mind that this meta-analysis was based on data abstracted from observational studies, these results may justify the risk-adapted therapeutic strategies for AML according to the FLT3 status...
  20. ncbi request reprint Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    F Hayakawa
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Oncogene 19:624-31. 2000
    ..Finally, we found constitutive activation of MAP kinase and STAT5 in all clinical samples of AML patients with mutant Flt3. Our study shows the significance of internal tandem duplication of Flt3 receptors for leukemia cell expansion...
  21. pmc B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells
    Y Hirose
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Immunology 104:410-7. 2001
    ..These results indicated that immature features of pre-B cells from CB, such as lack of TdT expression, and a short N region and few productive rearrangements in the IgH gene, might cause the delay in mature B-cell production...
  22. ncbi request reprint Escape mechanisms from antibody therapy to lymphoma cells: downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation
    Takumi Sugimoto
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 390:48-53. 2009
    ..These results suggest that recruitment of the Sin3A-HDAC1 complex is related to downregulation of CD20 expression in CD20-negative B-cells after treatment with rituximab...
  23. ncbi request reprint Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia
    Kazutaka Ozeki
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Blood 103:1901-8. 2004
    ..These results indicated that FLT3 overexpression may distinguish a novel disease entity in AML without FLT3 mutations and serve as a therapeutic target for FLT3 inhibitors...
  24. ncbi request reprint Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome
    M Iwai
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leukemia 19:1367-75. 2005
    ..These results suggested that FHIT methylation was accumulated through the disease progression of MDS and AML, and the role of the FHIT gene as a tumor suppressor seemed different in AML and MDS...
  25. ncbi request reprint Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo
    Akihide Atsumi
    Department of Hematology, Nagoya University Graduate School of Medicine, Showa Ku, Japan
    Biochem Biophys Res Commun 345:1471-80. 2006
    ..These results provide evidence to show that the N-CoR/HDAC3 co-repressor complex is involved in the aberrant transcription regulation in PML-RARalpha-expressing cells...
  26. ncbi request reprint Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene
    Manabu Ninomiya
    Department of Hematology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Genet Cytogenet 169:1-11. 2006
    ..These results suggest that TRL-01 is a useful cell line for studying not only the leukemia-related biology of MLL-ENL but also the intercellular association between leukemia and stroma...
  27. ncbi request reprint FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells
    T Kajiguchi
    Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Leukemia 21:2476-84. 2007
    ..These data demonstrate that FLT3 activation induces beta-catenin tyrosine phosphorylation and nuclear localization, and thus suggest a mechanism for the association of FLT3 activation and beta-catenin oncogeneic signaling in AML...
  28. ncbi request reprint High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia
    H Narimatsu
    Department of Hematology and Oncology, JA Aichi Showa Hospital, Konan, Japan
    Bone Marrow Transplant 40:773-8. 2007
    ..The unexpectedly high prevalence and the characteristics of SFPR may provide additional information on management following autologous SCT for acute myeloid leukemia...
  29. ncbi request reprint Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy
    Akihiro Tomita
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 86:49-57. 2007
    ..Thus, RRBL1 may be useful not only for analyses of mechanisms for the absence of CD20 expression in vitro but also for exploration of therapies against CD20- B-cell malignancies in vivo...
  30. ncbi request reprint Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication
    Akihiro Abe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 84:328-36. 2006
    ..FLT3 kinase inhibitor AG1296 specifically inhibited cell growth. NAMO-2 provides a useful tool to analyze adherence-dependent survival signaling of leukemia with FLT3/ITD and a model for the screening of FLT3 kinase inhibitors...
  31. doi request reprint Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment
    Yosuke Minami
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Hematol 92:664-6. 2010
    ..These results suggest that the monitoring of gene mutations in HSC and progenitors at diagnosis might be helpful for the early detection of TKI-resistant CML patients and facilitate appropriate therapeutic decision...
  32. pmc Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome
    Jinglan Xu
    Department of Haematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 140:394-401. 2008
    ..These findings suggest that in situ detection of nuclear NPBC by immunohistochemistry could provide new insights into the pathogenesis and prognosis of AML and MDS...
  33. doi request reprint Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review
    Makoto Murata
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Int J Hematol 88:111-5. 2008
    ..Peripheral blood stem cells might have an advantage in that they are associated with a low incidence of DCL development because PBSCT recipients receive a higher total cell dose than recipients of bone marrow or cord blood cells...
  34. doi request reprint Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan
    Hiroto Narimatsu
    Department of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan
    Int J Hematol 88:154-8. 2008
    ..Although these findings need to be confirmed with a larger number of patients, our data indicate that the MRD level at a given time during the early course in CR does not predict the outcome in Japanese patients...
  35. pmc Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy
    Akihiro Abe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 88:471-5. 2008
    ..Our results implicate that the sorted and purified stem cells are useful for more sensitive quantification of BCR-ABL-positive minimal residual disease...
  36. ncbi request reprint Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosmin protein level rarely occurs in myelodysplastic syndromes
    Yuichi Ishikawa
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, and Department of Infectious Diseases, Nagoya University Hospital, Showa Ku, Nagoya, Japan
    Leuk Lymphoma 49:2359-64. 2008
    ..It was concluded that abnormal cytoplasmic localisation and/or significant reduction of NPM1 protein level rarely occurs in MDS. The increase in the number of nuclear NPM1-positive cells may be related to the progression of MDS...
  37. doi request reprint Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance
    Junji Hiraga
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Japan
    Blood 113:4885-93. 2009
    ..These findings suggest that some epigenetic mechanisms may be partly related to the down-regulation of CD20 expression after rituximab treatment...
  38. doi request reprint Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study
    Yuichi Ishikawa
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:2186-92. 2010
    ..A prospective intervention study is required to establish PK-based management in CML patients treated with imatinib...
  39. ncbi request reprint Clinical features and outcome of T-lineage acute lymphoblastic leukemia in adults: a low initial white blood cell count, as well as a high count predict decreased survival rates
    Masamitsu Yanada
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Leuk Res 31:907-14. 2007
    ..0055 and 0.0037, respectively). Although our findings need confirmation, these results will be helpful in the identification of prognostically distinct subgroups within adult T-ALL...
  40. ncbi request reprint PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia
    Tomoko Yamamoto
    Departments of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leuk Res 30:1085-9. 2006
    ..These data suggest that PTPN11 mutation may play an important role for leukemogenesis in a proportion of children with ALL, particularly B precursor ALL...
  41. ncbi request reprint Nucleophosmin: a versatile molecule associated with hematological malignancies
    Tomoki Naoe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 97:963-9. 2006
    ..This review focuses on the clinical significance of the NPM1 gene in hematological malignancies and newly discovered roles of NPM associated with oncogenesis...
  42. ncbi request reprint Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Eur J Haematol 77:282-7. 2006
    ..Although there are two major scoring systems for the clinical diagnosis of disseminated intravascular coagulation (DIC), the validity of these systems for leukemia-associated DIC remains to be confirmed...
  43. ncbi request reprint Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leuk Lymphoma 45:1803-8. 2004
    ....
  44. ncbi request reprint Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: a single-center experience
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 74:418-23. 2005
    ..Our findings suggest that the WHO classification may be strengthened by greater emphasis on genetic/cytogenetic information...
  45. ncbi request reprint BMI-1 is highly expressed in M0-subtype acute myeloid leukemia
    Masashi Sawa
    Department of Molecular Medicine and Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 82:42-7. 2005
    ..These results indicated that a subgroup of M0 patients has a high expression level of polycomb group gene BMI-1, which may contribute to leukemogenesis...
  46. ncbi request reprint Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
    Tatsuya Suzuki
    Department of Infectious Diseases, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Blood 106:2854-61. 2005
    ..These results suggest that the NPM1 mutation is not necessarily an early event during leukemogenesis or that leukemia clones with NPM1 mutations are sensitive to chemotherapy...
  47. ncbi request reprint FLT3 mutations in acute myeloid leukemia
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Methods Mol Med 125:189-97. 2006
    ..Because the detection of FLT3 mutations is fast, easy, and inexpensive, mutation analysis should be performed as a routine test. This chapter describes methods for detecting ITD and D835 mutations in the FLT3 gene...
  48. ncbi request reprint Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia
    Yosuke Minami
    Department of Hematology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Blood 102:2969-75. 2003
    ..These findings suggest that the antiapoptotic pathways from FLT3/ITD are more divergent than those from WtFLT3 and may represent targets for drug discovery with the potential of inducing selective cell death of human leukemia cells...
  49. ncbi request reprint LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22)
    Shizuka Imagama
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 79:25-31. 2007
    ..We describe here a previously unreported rearrangement, t(11;21)(q13;q22), that disrupts the RUNX1 gene in a patient with acute leukemia and the molecular analysis of the fusion gene...
  50. ncbi request reprint Successful treatment with imatinib mesylate of a CML patient in megakaryoblastic crisis with severe fibrosis
    Yuka Hirose
    Department of Infectious Diseases, Nagoya University School of Medicine, Japan
    Int J Hematol 76:349-53. 2002
    ..The effect of imatinib on the long-term prognosis remains unclear, although the agent is clearly a promising drug for treating CML-BC even in cases of myelofibrosis...
  51. ncbi request reprint Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia
    T Naoe
    Department of Infectious Diseases, The First Nagoya University School of Medicine, Japan
    Clin Cancer Res 6:4091-5. 2000
    ..The polymorphism of the 5' promoter region of CYP3A4 was not found in persons of Japanese ethnicity. These results suggest that the NQOJ polymorphism is significantly associated with the genetic risk of TRLIMDS...
  52. doi request reprint Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD/SCID/IL-2Rgammac-/- mice
    Ryohei Tanizaki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:631-8. 2010
    ..These findings suggest that leukemia-repopulating cells in transformed Ph(+) leukemia are included in a lineage-committed but multilayered fraction, and that CD34(+) leukemia cells potentially emerge from CD34(-) populations...
  53. doi request reprint Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia
    Yuichi Ishikawa
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 83:90-8. 2009
    ..These results collectively suggest that TP53 mutation might be a functionally distinguishable class of mutation...
  54. ncbi request reprint [Novel molecularly target therapies for leukemia]
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine
    Nihon Rinsho 65:611-6. 2007
  55. doi request reprint Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma
    Kazuhito Yamamoto
    Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Aichi, Japan
    J Clin Oncol 28:1591-8. 2010
    ..This phase I study assessed the safety, pharmacokinetics, recommended phase II dose and efficacy of KW-0761 in patients with relapsed CCR4-positive adult T-cell leukemia-lymphoma (ATL) or peripheral T-cell lymphoma (PTCL)...
  56. ncbi request reprint Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia
    Sivasundaram Karnan
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
    Genes Chromosomes Cancer 45:420-5. 2006
    ..These results suggest that chromosomal imbalances are largely absent in APL, although some nonrandom chromosomal imbalances could be linked to the development of APL in a limited number of cases...
  57. ncbi request reprint A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RARalpha transcript after consolidation therapy: the Japan Adult Leukemia Study Group (JALSG) APL97 stud
    Norio Asou
    Department of Hematology, Kumamoto University School of Medicine, Kumamoto, Japan
    Blood 110:59-66. 2007
    ....
  58. ncbi request reprint Rapid screening of leukemia fusion transcripts in acute leukemia by real-time PCR
    Kazuoki Osumi
    Otsuka Assay Laboratories, Otsuka Pharmaceutical Co Ltd, Tokyo, Japan
    Leuk Lymphoma 43:2291-9. 2002
    ..This real-time PCR method enables rapid and efficient characterization of acute leukemia in addition to subsequent evaluation of minimal residual diseases...
  59. ncbi request reprint [Possibility of targeting FLT3 kinase for the treatment of leukemia]
    Hitoshi Kiyoi
    Rinsho Ketsueki 46:187-97. 2005
  60. doi request reprint Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome
    Tomohiko Sato
    Department of Paediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Br J Haematol 141:681-8. 2008
    ....
  61. ncbi request reprint Micafungin, a novel antifungal agent, as empirical therapy in acute leukemia patients with febrile neutropenia
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine
    Intern Med 45:259-64. 2006
    ..Empirical antifungal therapy with amphotericin B has been the standard of care for these patients; however, there remains a need for less toxic alternative drugs...
  62. ncbi request reprint [The present status of, and problems with the development of FLT3 kinase inhibitors]
    Hitoshi Kiyoi
    Rinsho Ketsueki 47:270-7. 2006
  63. ncbi request reprint [Mutation of the nucleophosmin gene in acute myeloid leukemia]
    Hitoshi Kiyoi
    Rinsho Ketsueki 47:710-6. 2006