Hiroshi Kitoh

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Orphanet J Rare Dis 8:163. 2013
  2. doi request reprint Prognostic factors for trochanteric overgrowth after containment treatment in Legg-Calvé-Perthes disease
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Japan
    J Pediatr Orthop B 22:432-6. 2013
  3. pmc Orthopaedic manifestations and diagnostic clues in children with Guillain-Barré syndrome
    Masaki Matsushita
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550 Japan
    J Child Orthop 7:177-82. 2013
  4. ncbi request reprint Sagittal spinal alignment in patients with Legg-Calve-Perthes disease
    Hiroshi Kitoh
    Department of Orthopedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    Pediatr Int 49:612-7. 2007
  5. doi request reprint A histological and ultrastructural study of the iliac crest apophysis in Legg-Calve-Perthes disease
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 28:435-9. 2008
  6. doi request reprint Predictive factors for unsuccessful treatment of developmental dysplasia of the hip by the Pavlik harness
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 29:552-7. 2009
  7. doi request reprint Differential effects of culture-expanded bone marrow cells on the regeneration of bone between the femoral and the tibial lengthenings
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 29:643-9. 2009
  8. doi request reprint Radiographic analysis of movements of the acetabulum and the femoral head after Salter innominate osteotomy
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 29:879-84. 2009
  9. doi request reprint Spondylometaphyseal dysplasia with cone-rod dystrophy
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Am J Med Genet A 155:845-9. 2011
  10. ncbi request reprint Distraction osteogenesis of the lower extremity in patients with achondroplasia/hypochondroplasia treated with transplantation of culture-expanded bone marrow cells and platelet-rich plasma
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 27:629-34. 2007

Collaborators

Detail Information

Publications38

  1. pmc Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Orphanet J Rare Dis 8:163. 2013
    ..Here, we conducted a prospective study to assess the efficacy and safety of Pex in the treatment of FOP patients...
  2. doi request reprint Prognostic factors for trochanteric overgrowth after containment treatment in Legg-Calvé-Perthes disease
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Japan
    J Pediatr Orthop B 22:432-6. 2013
    ..For the patients with decreased lateral pillar height, a careful follow-up is necessary to make an early decision of prophylactic epiphyseodesis of the greater trochanter. ..
  3. pmc Orthopaedic manifestations and diagnostic clues in children with Guillain-Barré syndrome
    Masaki Matsushita
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550 Japan
    J Child Orthop 7:177-82. 2013
    ..In the present study, we specifically describe orthopaedic manifestations and diagnostic clues in pediatric GBS...
  4. ncbi request reprint Sagittal spinal alignment in patients with Legg-Calve-Perthes disease
    Hiroshi Kitoh
    Department of Orthopedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    Pediatr Int 49:612-7. 2007
    ..In the present study sagittal spinal alignment of the patients with LCPD was analyzed to examine associated spinal involvement...
  5. doi request reprint A histological and ultrastructural study of the iliac crest apophysis in Legg-Calve-Perthes disease
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 28:435-9. 2008
    ..In this study, the biopsy specimens of the iliac crest apophysis from LCPD patients were examined histologically and ultrastructurally to determine preexisting generalized abnormalities of endochondral ossification...
  6. doi request reprint Predictive factors for unsuccessful treatment of developmental dysplasia of the hip by the Pavlik harness
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 29:552-7. 2009
    ..Predictive factors for unsuccessful Pavlik harness treatment should be determined for appropriate indication of the treatment and prevention of AVN...
  7. doi request reprint Differential effects of culture-expanded bone marrow cells on the regeneration of bone between the femoral and the tibial lengthenings
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 29:643-9. 2009
    ....
  8. doi request reprint Radiographic analysis of movements of the acetabulum and the femoral head after Salter innominate osteotomy
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 29:879-84. 2009
    ..Salter innominate osteotomy (SIO) is widely used to improve the coverage of the femoral head in dysplastic acetabulum, but the geometric change after osteotomy and its effect on the outcome have not been well elucidated...
  9. doi request reprint Spondylometaphyseal dysplasia with cone-rod dystrophy
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Am J Med Genet A 155:845-9. 2011
    ..Skeletal manifestations in addition to comprehensive ophthalmologic examinations were described in this patient who had been followed from infancy to 16 years of age...
  10. ncbi request reprint Distraction osteogenesis of the lower extremity in patients with achondroplasia/hypochondroplasia treated with transplantation of culture-expanded bone marrow cells and platelet-rich plasma
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 27:629-34. 2007
    ....
  11. ncbi request reprint Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis--a preliminary result of three cases
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Bone 35:892-8. 2004
    ....
  12. ncbi request reprint Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Aichi 466 8550, Japan
    Bone 40:522-8. 2007
    ..0004) In conclusion, transplantation of BMC and PRP shortened the treatment period and reduced associated complications by accelerating new bone formation in DO...
  13. ncbi request reprint Osteogenic potential of rat mesenchymal stem cells after several passages
    Fumiaki Sugiura
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Biochem Biophys Res Commun 316:233-9. 2004
    ..Establishment of the culture conditions that permit the rapid expansion of BMCs while retaining their potential for differentiation will be required for future clinical applications...
  14. doi request reprint Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice
    Ryuichiro Yamamoto
    Department of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 8550, Japan
    J Bone Miner Metab 31:26-33. 2013
    ..Fendiline, perhexiline, and their possible derivatives are potentially applicable to clinical practice to prevent devastating heterotopic ossification in FOP...
  15. ncbi request reprint A comparative study of blade plate fixation and external fixation in osteotomies for slipped capital femoral epiphysis
    Hiroshi Kitoh
    aDepartment of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya bDepartment of Orthopaedic Surgery, Aichi Children s Health and Medical Center, Obu, Japan
    J Pediatr Orthop B 22:542-7. 2013
    ..It has potential advantages over commonly used open techniques in terms of simplicity and less invasiveness. ..
  16. ncbi request reprint The effect of recombinant human bone morphogenetic protein-2 on the osteogenic potential of rat mesenchymal stem cells after several passages
    Hisato Ishikawa
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Acta Orthop 78:285-92. 2007
    ..Thus, we analyzed the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the osteogenic potential of rat BMSCs over several passages...
  17. ncbi request reprint A novel SOX9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome
    Masaki Matsushita
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Med Genet A 161:2528-34. 2013
    ..Retained residual SOX9 function might contribute to an extremely mild CD phenotype in the present cases. © 2013 Wiley Periodicals, Inc. ..
  18. doi request reprint Long-term outcome of gradual reduction using overhead traction for developmental dysplasia of the hip over 6 months of age
    Hiroshi Kaneko
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop 33:628-34. 2013
    ..The utility of gradual reduction (GR) using traction has insufficient evidence. We therefore report the long-term outcome of GR using overhead traction (OHT)...
  19. pmc Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia
    Masaki Matsushita
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 8:e81569. 2013
    ..We propose that meclozine is a potential therapeutic agent for treating ACH and other FGFR3-related skeletal dysplasias. ..
  20. ncbi request reprint Prediction of acetabular development after closed reduction by overhead traction in developmental dysplasia of the hip
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    J Orthop Sci 11:473-7. 2006
    ..The objective of this study was to find early and reliable predictors of future acetabular dysplasia in the hips reduced by overhead traction (OHT)...
  21. ncbi request reprint [Molecular mechanism in the differentiation of chondrocytes]
    Hiroshi Kitoh
    Nagoya University School of Medicine, Department of Orthopaedic Surgery
    Clin Calcium 17:493-8. 2007
    ..Here, we summarize the functions of these molecules and their networks for the differentiation and maturation of chondrocytes...
  22. ncbi request reprint Home traction in the treatment schedule of overhead traction for developmental dysplasia of the hip
    Takahiko Kitakoji
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Orthop Sci 10:475-9. 2005
    ..The objective of this study was to investigate the efficacy and safety of home traction in the treatment schedule of OHT for DDH...
  23. doi request reprint A novel in-frame deletion of the RUNX2 gene causes a classic form of cleidocranial dysplasia
    Masaki Matsushita
    Departments of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    J Bone Miner Metab 32:96-9. 2014
    ..Destruction of RUNX2/PEBP2β heterodimerization activity appears to impair the function of the RUNX2 protein and cause the disease. ..
  24. doi request reprint Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8
    Hiroshi Kaneko
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Hum Genet 130:671-83. 2011
    ..GPATCH8 is only 5.8 Mbp distant from COL1A1 and encodes a protein harboring an RNA-processing domain and a zinc finger domain, but the molecular functions have not been elucidated to date...
  25. doi request reprint Isolated bifid rib: clinical and radiological findings in children
    Hiroshi Kaneko
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Int 54:820-3. 2012
    ..Bifid rib is usually asymptomatic but sometimes occurs associated with other pathological conditions. The aim of this study was to investigate clinical and radiological characteristics in children with bifid rib...
  26. doi request reprint Chondroblastoma of the femoral neck as a cause of hip synovitis
    Hiroshi Kaneko
    Department of Orthopaedic Surgery, Nagoya University, School of Medicine, Nagoya, Aichi, Japan
    J Pediatr Orthop B 21:179-82. 2012
    ..Complete relief of pain and an improvement in the range of movement of the hip joint was obtained after surgical resection of the tumor...
  27. ncbi request reprint Patellar dislocation in achondroplasia
    Yuji Takamine
    Department of Orthopaedic Surgery, Central Hospital, Aichi Welfare Center for Persons with Developmental Disabilities, Kasugai, Aichi, Japan
    J Pediatr Orthop B 17:47-9. 2008
    ..Patellar dislocation for achondroplasia may be caused not only by the abnormalities of soft tissue but also a small groove of patellofemoral joint as a bony malformation...
  28. ncbi request reprint Benign prenatal hypophosphatasia: a treatable disease not to be missed
    Masaki Matsushita
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Pediatr Radiol 44:340-3. 2014
    ..Benign prenatal hypophosphatasia should be considered in the differential diagnosis of congenital bowing of the long bones. ..
  29. ncbi request reprint Spatial and temporal distribution of growth factors receptors in the callus: implications for improvement of distraction osteogenesis
    Karolina A Siwicka
    Nagoya University Graduate School of Medicine, Department of Orthopaedic Surgery, Nagoya, Japan
    Nagoya J Med Sci 73:117-27. 2011
    ..Rapid decline of growth factors receptors in the fibrous zone may imply its decreasing sensitivity to growth factors and, as a consequence, a declining osteogenic potential...
  30. ncbi request reprint Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells
    Hiroki Tsuchiya
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Biochem Biophys Res Commun 301:338-43. 2003
    ..These results indicated that cell-mediated sox9 gene therapy could be a novel strategy for hyaline cartilage damage...
  31. ncbi request reprint Deformities of the elbow in achondroplasia
    Hiroshi Kitoh
    Department of Orthopaedic Surgery, School of Medicine, Nagoya University, Aichi, Japan
    J Bone Joint Surg Br 84:680-3. 2002
    ..3 degrees). Posterior bowing of the distal humerus is a principal cause of loss of extension of the elbow. Posterior dislocation of the radial head causes further limitation of movement in the more severely affected joints...
  32. doi request reprint Deformity of the great toe in fibrodysplasia ossificans progressiva
    Yasuharu Nakashima
    Department of Orthopaedic Surgery, Kyushu University, 1 3 3 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Orthop Sci 15:804-9. 2010
    ..The present study was conducted to examine the characteristics of the great toe deformity in patients with FOP, which may lead to an early diagnosis of this condition...
  33. pmc Factors related to surgical outcome after posterior decompression and fusion for craniocervical junction lesions associated with osteogenesis imperfecta
    Shiro Imagama
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya, Aichi 466 8550, Japan
    Eur Spine J 20:S320-5. 2011
    ....
  34. ncbi request reprint A recurrent mutation in type II collagen gene causes Legg-Calvé-Perthes disease in a Japanese family
    Yoshinari Miyamoto
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Hum Genet 121:625-9. 2007
    ..This is the first report of a mutation in hereditary LCPD. COL2A1 mutations may be more common in LCPD patients than currently thought, particularly in familial and/or bilateral cases...
  35. ncbi request reprint Novel and recurrent mutations clustered in the von Willebrand factor A domain of MATN3 in multiple epiphyseal dysplasia
    Akihiko Mabuchi
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 108 8639 Tokyo, Japan
    Hum Mutat 24:439-40. 2004
    ..120-127). Contrary to the previous assumption that the MATN3 mutation in MED is confined to the beta-sheet regions, one novel mutation (p.F105S) is located outside the beta-sheet region, within an alpha-helix region...
  36. ncbi request reprint Novel types of COMP mutations and genotype-phenotype association in pseudoachondroplasia and multiple epiphyseal dysplasia
    Akihiko Mabuchi
    Laboratory for Bone and Joint Deseases, SNP Research Center, RIKEN, c o Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Hum Genet 112:84-90. 2003
    ..0024). These findings expand the mutation spectrum of the COMP gene and highlight genotype-phenotype relationships, facilitating improved genetic diagnosis and analysis of COMP function in humans...
  37. ncbi request reprint SHOX nullizygosity and haploinsufficiency in a Japanese family: implication for the development of Turner skeletal features
    Tsutomu Ogata
    Department of Pediatrics, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 87:1390-4. 2002
    ....