Hiroshi Kimura

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Viral load in Epstein-Barr virus-associated hemophagocytic syndrome
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Microbiol Immunol 46:579-82. 2002
  2. pmc Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2
    Chenhong Luo
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Front Microbiol 3:158. 2012
  3. pmc Generation and Characterization of UL21-Null Herpes Simplex Virus Type 1
    Yoshifumi Muto
    Department of Virology, Nagoya University Graduate School of Medicine Nagoya, Japan
    Front Microbiol 3:394. 2012
  4. ncbi request reprint [Chronic active Epstein-Barr virus infection]
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine 65 Turumai cho, Showa Ku, Nagoya 466 8550, Japan
    Uirusu 61:163-73. 2011
  5. doi request reprint EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases
    Hiroshi Kimura
    Departments of Virology, Nagoya University Graduate School of Medicine, Japan
    Blood 119:673-86. 2012
  6. ncbi request reprint Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Med Virol 67:349-53. 2002
  7. ncbi request reprint Clinical and virologic characteristics of chronic active Epstein-Barr virus infection
    H Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    Blood 98:280-6. 2001
  8. ncbi request reprint Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease
    Hiroshi Kimura
    Department of Virology Nagoya University Graduate School of Medicine, Nagoya, Japan
    Rev Med Virol 18:305-19. 2008
  9. ncbi request reprint Prognostic factors for chronic active Epstein-Barr virus infection
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 187:527-33. 2003
  10. doi request reprint Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 200:1078-87. 2009

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Viral load in Epstein-Barr virus-associated hemophagocytic syndrome
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Microbiol Immunol 46:579-82. 2002
    ..The difference in viral load seemed to be clearer in peripheral blood mononuclear cells than in plasma...
  2. pmc Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2
    Chenhong Luo
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Front Microbiol 3:158. 2012
    ..These data indicate that the live attenuated HSV-1 mutant strain HF10 is a promising candidate antigen for a vaccine against genital herpes caused by HSV-2...
  3. pmc Generation and Characterization of UL21-Null Herpes Simplex Virus Type 1
    Yoshifumi Muto
    Department of Virology, Nagoya University Graduate School of Medicine Nagoya, Japan
    Front Microbiol 3:394. 2012
    ..These results will help clarify the function of UL21 and broaden our understanding of the life cycle of HSV...
  4. ncbi request reprint [Chronic active Epstein-Barr virus infection]
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine 65 Turumai cho, Showa Ku, Nagoya 466 8550, Japan
    Uirusu 61:163-73. 2011
    ..In this review, I discuss our current understanding of the pathogenesis of CAEBV and summarize its clinical features, therapies, and prognosis...
  5. doi request reprint EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases
    Hiroshi Kimura
    Departments of Virology, Nagoya University Graduate School of Medicine, Japan
    Blood 119:673-86. 2012
    ..These data depict clinical characteristics of systemic EBV(+) T/NK-LPD and provide insight into the diagnostic and therapeutic approaches for distinct disease...
  6. ncbi request reprint Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Med Virol 67:349-53. 2002
    ..These results suggest that quantitation of HSV viral load may be useful for assessing the prognosis, and may provide additional information for the management of neonatal HSV infection...
  7. ncbi request reprint Clinical and virologic characteristics of chronic active Epstein-Barr virus infection
    H Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    Blood 98:280-6. 2001
    ..Over a 68-month period of observation, 10 patients died from hepatic failure, malignant lymphoma, or other causes. Patients with T-cell CAEBV had a shorter survival time than those with NK-cell type of disease...
  8. ncbi request reprint Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease
    Hiroshi Kimura
    Department of Virology Nagoya University Graduate School of Medicine, Nagoya, Japan
    Rev Med Virol 18:305-19. 2008
    ..The EBV real-time PCR assay system must be standardised for large-scale studies and international comparisons...
  9. ncbi request reprint Prognostic factors for chronic active Epstein-Barr virus infection
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 187:527-33. 2003
    ..59 vs. 0.87; P<.009). Patients with CAEBV with late onset of disease, thrombocytopenia, and T cell infection had significantly poorer outcomes...
  10. doi request reprint Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 200:1078-87. 2009
    ....
  11. ncbi request reprint Vidarabine therapy for severe chronic active Epstein-Barr virus infection
    H Kimura
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    J Pediatr Hematol Oncol 23:294-9. 2001
    ..We administered vidarabine to patients with natural killer (NK) cell-type SCAEBV and evaluated clinical and virologic effects...
  12. ncbi request reprint Monitoring of cell-free viral DNA in primary Epstein-Barr virus infection
    H Kimura
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Med Microbiol Immunol 188:197-202. 2000
    ..Measuring the cell-free EBV-DNA is useful for monitoring the primary EBV infection, especially in EBV-AHS...
  13. pmc Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay
    H Kimura
    Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Japan
    J Clin Microbiol 37:132-6. 1999
    ..842; P < 0.0001). These results indicate that the real-time PCR assay is useful for diagnosing symptomatic EBV infection and for monitoring the virus load...
  14. ncbi request reprint Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 191:531-9. 2005
    ..These findings should help to clarify the pathogenesis of CAEBV infection and facilitate the development of more-effective treatments...
  15. ncbi request reprint Rapid detection of herpes simplex virus DNA in cerebrospinal fluid: comparison between loop-mediated isothermal amplification and real-time PCR
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Med Microbiol Immunol 194:181-5. 2005
    ..Although further improvement is necessary for the wide spread use, the LAMP method might be applicable to diagnosis of HSV infection of the central nervous system...
  16. pmc Relapse of neonatal herpes simplex virus infection
    H Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Arch Dis Child Fetal Neonatal Ed 88:F483-6. 2003
    ..Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. Recurrence of skin vesicles is common...
  17. pmc Comparison of quantitations of viral load in varicella and zoster
    H Kimura
    Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Japan
    J Clin Microbiol 38:2447-9. 2000
    ..A higher occurrence of viremic VZV DNA was observed in varicella than in zoster. Acyclovir treatment resulted in marked suppression of viremia in varicella...
  18. doi request reprint Immunologic and virologic analyses in pediatric liver transplant recipients with chronic high Epstein-Barr virus loads
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Infect Dis 202:461-9. 2010
    ..Long-term Epstein-Barr virus (EBV) monitoring for potentially life-threatening posttransplant lymphoproliferative disorder (PTLD) has identified asymptomatic patients who maintain high EBV loads over long periods...
  19. doi request reprint Clinical and virological characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Infect Dis 46:1525-34. 2008
    ..Recently, hematopoietic stem cell transplantation (HSCT) has been introduced and has the potential to become a standard treatment, although guidelines for HSCT to treat chronic active EBV infection have not yet been proposed...
  20. ncbi request reprint Detection of herpesvirus DNA in the serum of immunocompetent children
    Shinya Hara
    Department of Pediatrics, Nagoya University School of Medicine, Aichi, Japan
    Microbiol Immunol 46:177-80. 2002
    ..When herpesvirus DNA is detected in the serum, a careful interpretation is necessary to diagnose a primary infection or a virus-associated disease...
  21. doi request reprint Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 197:663-6. 2008
    ..These genes may be associated with the inflammatory reaction or with cell proliferation...
  22. pmc Simultaneous quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay
    Kaoru Wada
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Clin Microbiol 45:1426-32. 2007
    ..These results demonstrate that whole blood is more suitable for the quantification of EBV DNA in transplant patients. However, a cutoff value with clinical relevance still needs to be determined...
  23. doi request reprint Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7
    Kaoru Wada
    Deparmtent of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Microbiol Immunol 53:22-9. 2009
    ..The detection rate for each viral DNA was 6.7% for HSV, 9.5% for HHV-6, and 1.9% for HHV-7. These results indicate that our system is reliable and may be useful for the rapid diagnosis of viral encephalitis/encephalopathy...
  24. ncbi request reprint Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in patients with chronic active EBV infection
    Naomi Sugaya
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Japan
    J Infect Dis 190:985-8. 2004
    ..Low frequencies of EBV-specific CD8+ T cells may be one of the immunological features of chronic active EBV infection...
  25. pmc Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch
    Yoko Ushijima
    Department of Virology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Virol J 7:179. 2010
    ..Additionally, we assessed the similarity between UL56 and regulatory proteins of Itch and Nedd4, Nedd4-family-interactins proteins (Ndfip)...
  26. ncbi request reprint Ganciclovir therapy for congenital cytomegalovirus infection in six infants
    Naoko Tanaka-Kitajima
    Department of Pediatrics, Nagoya Memorial Hospital, Japan
    Pediatr Infect Dis J 24:782-5. 2005
    ..Congenital cytomegalovirus (CMV) infection is common, and its morbidity rate is high. Ganciclovir (GCV) treatment has been used for congenital CMV infection, but there are few reports on viral loads associated with GCV therapy...
  27. ncbi request reprint One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection
    Naomi Kubota
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Virol Methods 147:26-36. 2008
    ..Because of its rapidity, sensitivity, and specificity, this new assay can be used for quantitative analyses of the latency patterns of EBV infection and the switch from latency to lytic viral replication...
  28. ncbi request reprint Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Int 55:566-71. 2013
    ..Congenital cytomegalovirus (CMV) infection and neonatal herpes are major mother-to-child infections, and analyses of the important clinical issues, including risk factors for prognosis, are essential...
  29. ncbi request reprint Immunogenicity of inactivated seasonal influenza vaccine in adult and pediatric liver transplant recipients over two seasons
    Michio Suzuki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Microbiol Immunol 57:715-22. 2013
    ..Influenza infection was more frequent in pediatric recipients. Long-term response to preceding vaccinations appeared to be insufficient in both groups. ..
  30. ncbi request reprint Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR; comparison to detection of viral DNA in plasma by qualitative PCR
    Masaru Ihira
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Microbiol Immunol 46:701-5. 2002
    ..033). In patients with HHV-6 viremia, mean HHV-6 DNA copy number was higher in the samples collected at 2 weeks after BMT than the samples collected at any other time period...
  31. pmc Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions
    Yoko Ushijima
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Virol J 6:168. 2009
    ....
  32. ncbi request reprint Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following ganciclovir treatment
    Chenhong Luo
    Department of Virology, Nagoya University Graduate School of Medicine, Tsuruma, Nagoya 466 8550, Japan
    J Gene Med 9:875-83. 2007
    ..These results suggest that infection with replication-competent HSV-1 induces the bystander effect in cells treated with GCV because of efficient intercellular transport of active GCV through abundant gap junctions...
  33. ncbi request reprint Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 190:494-8. 2004
    ..It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection...
  34. ncbi request reprint Rapid detection of Epstein-Barr virus DNA by loop-mediated isothermal amplification method
    Seiko Iwata
    Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan
    J Clin Virol 37:128-33. 2006
    ..The loop-mediated isothermal amplification (LAMP) method is a novel technique for the amplification of specific DNA sequences...
  35. ncbi request reprint Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    J Med Virol 81:1399-402. 2009
    ..8 x 10(2) copies/ml of whole blood, respectively, suggesting that the viruses were associated with the clinical condition. Recognizing that coinfection with these viruses may modulate the clinical course of disease is important...
  36. ncbi request reprint Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein-Barr virus infection
    Yukiko Shibata
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 78:770-9. 2006
    ..Collectively, these findings are critical to clarify further the pathogenesis of chronic active EBV infection and aid in the development of effective treatment strategies...
  37. doi request reprint Quantitative analysis of Epstein-Barr virus (EBV)-related gene expression in patients with chronic active EBV infection
    Seiko Iwata
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gen Virol 91:42-50. 2010
    ..Quantifying EBV gene expression is useful in clarifying the pathogenesis of CAEBV infection and may provide information regarding a patient's disease prognosis, as well as possible therapeutic interventions...
  38. ncbi request reprint Acute retinal necrosis caused by herpes simplex virus type 2 in a 3-year-old Japanese boy
    Naoko Tanaka-Kitajima
    Department of Infection and Immunology, Aichi Children s Health and Medical Center, Aichi, Japan
    Eur J Pediatr 168:1125-8. 2009
    ..Pediatricians must be aware of this rare disease, which can affect individuals without a previous history of HSV even in a country with a low seroprevalence of HSV-2...
  39. doi request reprint Herpes simplex virus induces extensive modification and dynamic relocalisation of the nuclear mitotic apparatus (NuMA) protein in interphase cells
    Yohei Yamauchi
    Department of Virology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    J Cell Sci 121:2087-96. 2008
    ..In summary, we suggest that NuMA is required for efficient HSV infection, and identify further areas of research that address how the virus challenges host cell barriers...
  40. pmc Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma
    Takayuki Murata
    Division of Virology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
    PLoS ONE 8:e63566. 2013
    ..Tumor formation in immuno-defficient NOD/Shi-scid/IL-2Rγ(null) (NOG) mice was also retarded. These results suggest that HSP90 inhibitors can be alternative treatments for patients with EBV-positive malignancies...
  41. ncbi request reprint Systemic cytokine responses in patients with influenza-associated encephalopathy
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 188:690-8. 2003
    ..These results suggest that influenza-associated encephalopathy might be a consequence of systemic immune responses...
  42. doi request reprint Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy
    Shinji Kawabe
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 82:1410-5. 2010
    ..038). The distribution of these cytokines differed between CSF and serum. The high CSF concentration of IL-8 could play an important role in the pathogenesis of encephalopathy...
  43. doi request reprint Identification of Epstein-Barr virus-infected CD27+ memory B-cells in liver or stem cell transplant patients
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gen Virol 92:2590-5. 2011
    ..88, P < 0.0001). The FISH assay enabled us to characterize EBV-infected cells and perform a quantitative analysis in patients with EBV infection after stem cell/liver transplantation...
  44. ncbi request reprint Association of virus infected-T cell in severe hepatitis caused by primary Epstein-Barr virus infection
    Shinya Hara
    Department of Pediatrics, Toyota Memorial Hospital, Toyota, Japan
    J Clin Virol 35:250-6. 2006
    ..Infectious mononucleosis owing to primary Epstein-Barr virus (EBV) infection sometimes causes hepatitis, which is usually self-limiting with mildly elevated transaminases, but can rarely develop into severe hepatitis with jaundice...
  45. ncbi request reprint Comparison of real-time and nested PCR assays for detection of herpes simplex virus DNA
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Microbiol Immunol 48:411-5. 2004
    ..Quantification of HSV DNA by real-time PCR was useful for diagnosing and monitoring patients with HSV encephalitis and neonatal HSV infection...
  46. pmc Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1
    Zhuan Li
    Department of Virology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    J Virol 86:492-503. 2012
    ..Moreover, XAV939, an inhibitor of tankyrase PARP activity, decreased viral titers to 2 to 5% of control values. We concluded that HSV targets tankyrase 1 in an ICP0- and ERK-dependent manner to facilitate its replication...
  47. ncbi request reprint Epstein-Barr virus-specific T-cell cytotoxicity is mediated through the perforin pathway in patients with lymphoproliferative disorders after allogeneic bone marrow transplantation
    Ayami Yoshimi
    The Department of Pediatrics Developmental Pediatrics, Nagoya University School of Medicine, Japan
    Br J Haematol 116:710-5. 2002
    ....
  48. ncbi request reprint Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay
    Ayako Yasuda
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    Pediatrics 111:1333-6. 2003
    ..Breast milk is the main source of perinatal CMV infections. This study evaluated the kinetics of CMV load in breast milk and the rate of postnatal CMV transmission via breast milk from mothers to their preterm infants...
  49. ncbi request reprint Flow cytometric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection
    Naomi Hayashi
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Med Virol 71:251-8. 2003
    ..The present study points to impairment of CMV-specific cellular immunity in patients in single-cell levels with congenital CMV infection during the infant period and possible restoration in later childhood...
  50. ncbi request reprint Evaluation of apoptosis in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 78:400-7. 2006
    ..These results suggest that apoptosis, which is dependent on the EBV load and could be mediated by TNF-alpha, plays a major role in the pathophysiology of EBV-associated HLH...
  51. ncbi request reprint Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus
    Yoko Ushijima
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Microbes Infect 9:142-9. 2007
    ..5, US10 and US12 exhibited a relatively high divergence. These data provide the genetic background of HF10 and insight into the molecular mechanism of HSV-1 replication and pathogenicity...
  52. doi request reprint Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection
    Yoshihiko Kawano
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 208:771-9. 2013
    ..MicroRNAs (miRNAs) are small noncoding RNAs, and EBV encodes multiple miRNAs. Because plasma contains sufficiently stable miRNAs, circulating EBV-associated miRNA profiles were investigated as novel biomarkers in CAEBV infection...
  53. pmc Different distributions of Epstein-Barr virus early and late gene transcripts within viral replication compartments
    Atsuko Sugimoto
    Division of Virology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Virol 87:6693-9. 2013
    ..From these results, we speculate that sites for viral early and late gene transcription are separated with reference to BMRF1 cores...
  54. ncbi request reprint Bortezomib induces apoptosis in T lymphoma cells and natural killer lymphoma cells independent of Epstein-Barr virus infection
    Seiko Iwata
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 129:2263-73. 2011
    ..Bortezomib had a greater killing effect on EBV-infected cells. These results indicate that bortezomib killed T or NK lymphoma cells by inducing apoptosis, regardless of the presence or absence of EBV...
  55. doi request reprint Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children
    Yoshinori Ito
    Department of Pediatrics, Nagoya University, Graduate School of Medicine, and Nagoya Ekisaikai Hospital, Nagoya, Japan
    Cytokine 56:180-7. 2011
    ..The 2009 A(H1N1) influenza virus has caused a large outbreak, and resulted in major complications of severe pneumonia and acute encephalopathy in the pediatric population in Japan...
  56. pmc Replication of Epstein-Barr virus primary infection in human tonsil tissue explants
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 6:e25490. 2011
    ..These data suggest that this model has potential for use in the pathological analysis of local tissues at the time of primary infection, as well as for screening novel antiviral agents...
  57. ncbi request reprint Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Pediatr Infect Dis J 22:115-9. 2003
    ..AIM To confirm or refute the association between influenza-associated encephalopathy and HHV-6 or HHV-7...
  58. pmc Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16
    Akane Ohta
    Department of Virology, Graduate School of Medicine, Nagoya University, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Virol J 8:365. 2011
    ..et al, 2008). UL14 of herpes simplex virus type 2 exhibits multiple functions (Yamauchi Y. et al, 2001, 2002, 2003)...
  59. pmc Pharmacokinetics and effects of ribavirin following intraventricular administration for treatment of subacute sclerosing panencephalitis
    Mitsuaki Hosoya
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Antimicrob Agents Chemother 48:4631-5. 2004
    ..Intraventricular ribavirin therapy should be pursued further for its potential use for patients with SSPE and might be applied in the treatment of patients with encephalitis caused by other RNA viruses...
  60. doi request reprint Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases
    Shinji Kawabe
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 103:1481-8. 2012
    ....
  61. doi request reprint Enhanced antitumoral activity of oncolytic herpes simplex virus with gemcitabine using colorectal tumor models
    Shinichi Esaki
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Int J Cancer 132:1592-601. 2013
    ..Intratumoral injection of oncolytic HSVs following GEM injection reduced MDSCs. Repeated treatment with oncolytic HSVs following GEM resulted in enhanced oncolytic activity...
  62. pmc Multiplex real-time PCR assay for simultaneous quantification of BK polyomavirus, JC polyomavirus, and adenovirus DNA
    Yasuhito Funahashi
    Department of Urology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Clin Microbiol 48:825-30. 2010
    ..Since this new assay is rapid, sensitive, and specific, it can be used for quantitative analyses of viruses in urine and serum samples after transplantation...
  63. ncbi request reprint Association of cytomegalovirus with infantile hepatitis
    Yukiko Shibata
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Microbiol Immunol 49:771-7. 2005
    ..These results indicate that CMV might be one of the major pathogens responsible for infantile hepatitis; however, serological tests have limited utility for the diagnosis of CMV infection in young children...
  64. doi request reprint Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients
    Yuka Torii
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Vaccine 29:4187-9. 2011
    ..These findings suggest that pediatric liver transplant patients may respond safely to inactivated 2009 H1N1 influenza vaccines in a manner similar to immunocompetent children...
  65. ncbi request reprint Hemiconvulsion-hemiplegia syndrome and primary human herpesvirus 7 infection
    Jun ichi Kawada
    Department of Pediatrics, Okazaki City Hospital, Okazaki, Aichi, Japan
    Brain Dev 26:412-4. 2004
    ..DWI are useful for the early evaluation of HH syndrome. Vascular disorders due to HHV-7 infection may have been related to the development of HH syndrome in this patient...
  66. pmc Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0
    Maki Kamakura
    Department of Virology, Nagoya Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Virol J 8:257. 2011
    ..To understand the regulatory mechanisms involved, we initiated studies focusing on the zinc finger transcription factor insulinoma-associated 1 (INSM1), a host cell protein markedly up-regulated by HSV infection...
  67. pmc The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids
    Yohei Yamauchi
    Department of Virology, Graduate School of Medicine, Nagoya University, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    J Virol 82:1094-106. 2008
    ..The tegument protein UL14 could be part of the machinery that regulates HSV-1 replication...
  68. pmc Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination
    Yoko Ushijima
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Virol 82:5220-33. 2008
    ..Based on these findings, we propose that UL56 regulates Nedd4 in HSV-2-infected cells, although deletion of UL56 had no apparent effect on viral growth in vitro...
  69. ncbi request reprint Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection
    Motohiko Okano
    Department of Pediatrics, Hokkaido University Hospital, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Hematol 80:64-9. 2005
    ..Guidelines, derived mainly from the current literature and recent experiences with CAEBV in Japan, for diagnosing CAEBV are proposed to clarify this enigmatic disease...
  70. ncbi request reprint Pathogenesis of chronic active Epstein-Barr virus infection: is this an infectious disease, lymphoproliferative disorder, or immunodeficiency?
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Turumai cho, Showa Ku, Nagoya, Japan
    Rev Med Virol 16:251-61. 2006
    ..In this review, I summarise our current understanding of the pathogenesis of CAEBV and propose a model of CAEBV pathogenicity...
  71. doi request reprint Kinetics of Epstein-Barr virus load and virus-specific CD8+ T cells in acute infectious mononucleosis
    Yo Hoshino
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    J Clin Virol 50:244-6. 2011
    ..The actual contribution of EBV-specific CD8(+) T cells in reducing EBV load, however, is not known...
  72. ncbi request reprint [Treatment of neonatal herpes]
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine
    Nihon Rinsho 64:302-5. 2006
  73. ncbi request reprint Severe hepatitis caused by Epstein-Barr virus without infection of hepatocytes
    H Kimura
    Departments of Pediatrics, Clinical Pathology, and Health Science, Nagoya University School of Medicine; and the Laboratory of Viral Oncology, Aichi Cancer Research Institute, Nagoya, Japan
    Hum Pathol 32:757-62. 2001
    ..The CD8(+) T cells, not hepatocytes, were positive for EBV. Possible mechanisms of viral hepatitis without infection of hepatocytes are discussed...
  74. ncbi request reprint Congenital cytomegalovirus infection diagnosed by polymerase chain reaction with the use of preserved umbilical cord
    Hiroko Kakizawa
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Pediatr Infect Dis J 24:653-4. 2005
    ..Congenital cytomegalovirus infection was suspected on the basis of magnetic resonance imaging that showed abnormal signal intensities in the gray-white matter junction...
  75. ncbi request reprint Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gen Virol 87:1677-83. 2006
    ..These results should help to clarify the pathogenesis of influenza and its neurological complications...
  76. ncbi request reprint [Chronic active EBV infection]
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine
    Nihon Rinsho 64:630-4. 2006
  77. doi request reprint Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss
    Terukazu Mizuno
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Eur Arch Otorhinolaryngol 266:351-5. 2009
    ..CMV DNA was not detected in any of the patients with sudden SNHL or enlarged vestibular aqueduct-associated SNHL. The features of CMV-associated SNHL were more asymmetric than those of CMV-negative bilateral SNHL...
  78. ncbi request reprint Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR
    Shinya Asano
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Aichi 4668550, Japan
    J Clin Virol 29:206-9. 2004
    ..It is not clear whether quantitative analysis of viral DNA in ocular specimens is correlated with disease activities of acute retinal necrosis (ARN)...
  79. ncbi request reprint Virological aspects of Epstein-Barr virus infections
    Nobuko Yamashita
    Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Acta Med Okayama 59:239-46. 2005
    ..The pathogenesis of EBV-infected T/NK cells, and the host immune response to infection, including the roles carried out by innate immunity and inflammatory cytokines, are likely to be revealed in the future...
  80. ncbi request reprint Quantitative analysis of herpesvirus load in the lymph nodes of patients with histiocytic necrotizing lymphadenitis using a real-time PCR assay
    Nagako Maeda
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diagn Mol Pathol 15:49-55. 2006
    ....
  81. doi request reprint Simultaneous monitoring by real-time polymerase chain reaction of epstein-barr virus, human cytomegalovirus, and human herpesvirus-6 in juvenile and adult liver transplant recipients
    Y Ono
    Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Transplant Proc 40:3578-82. 2008
    ..The rate of acute cellular rejection was not significantly higher in the CMV-, EBV-, or HHV-6-positive groups. Simultaneous monitoring for 3 herpesviruses revealed the impact of these viruses on LDLT recipients...
  82. ncbi request reprint Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8(+) T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay
    K Kuzushima
    Division of Virology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 98:1872-81. 2001
    ..79% of CD8(+) T cells in peripheral blood from a seropositive donor. The peptide could be a useful reagent to study CTL responses to CMV among populations positive for HLA-A*2402...
  83. ncbi request reprint [Diagnosis of herpesvirus infection]
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine
    Nihon Rinsho 64:55-8. 2006
  84. pmc Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles
    Naoki Nozawa
    Department of Virology, Nagoya University Graduate School of Medicine Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    J Virol 79:6947-56. 2005
    ..These defects were fully rescued by reinsertion of the UL51 gene. These results indicate that UL51 protein is involved in the maturation and egress of HSV-1 virus particles downstream of the initial envelopment step...
  85. ncbi request reprint Impaired cytotoxic T lymphocyte response to Epstein-Barr virus-infected NK cells in patients with severe chronic active EBV infection
    I Tsuge
    Department of Pediatrics, Nagoya University School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan
    J Med Virol 64:141-8. 2001
    ..From these findings, two treatment options for severe chronic active EBV infection are offered for consideration: adoptive transfer of in vitro-cultured CTL, and bone marrow transplantation from HLA-identical donors...
  86. ncbi request reprint Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes
    Haruhiko Suzuki
    Department of Immunology, Nagoya University Graduate School of Medicine, Aichi 466 8550, Japan
    FASEB J 17:1538-40. 2003
    ..These results indicate that MKK6 plays a role in the developing thymocytes, especially in the population of TCRalphabeta(int)CD69lo cells, which possibly undergo negative selection...
  87. doi request reprint Multicenter evaluation of prototype real-time PCR assays for Epstein-Barr virus and cytomegalovirus DNA in whole blood samples from transplant recipients
    Yoshinori Ito
    Pediatrics Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Microbiol Immunol 54:516-22. 2010
    ..Such standardization will help to standardize the diagnosis and monitoring of diseases associated with EBV and CMV...
  88. ncbi request reprint Helicobacter pylori infection in patients with idiopathic short stature
    Masahisa Takahashi
    Department of Pediatrics, Nagoya University School of Medicine, Aichi, Japan
    Pediatr Int 44:277-80. 2002
    ..Some investigators have recently described an association between Helicobacter pylori infection and children with short stature. In the present study, we aimed to evaluate children with short stature with different etiologies...
  89. ncbi request reprint Prophylactic oral acyclovir in outbreaks of primary herpes simplex virus type 1 infection in a closed community
    K Kuzushima
    Department of Pediatrics, Nagoya University, School of Medicine, Japan
    Pediatrics 89:379-83. 1992
    ..In conclusion, short-term prophylactic acyclovir may limit the spread and reduce clinical manifestations of HSV infections in closed communities, although this use should be restricted to communities where severe symptoms are observed...
  90. ncbi request reprint Expression of tegument protein pp65 of human cytomegalovirus (CMV) and its application to the analysis of viral-specific cellular immunity in CMV-infected individuals
    N Tanaka
    Department of Pediatrics, Developmental Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Arch Virol 147:2405-17. 2002
    ..The delay in re-constitution in CMV-specific cellular immunity was associated with reactivation of CMV. These results indicated that the recombinant protein pp65 can be used to study specific immunity in CMV infections...
  91. ncbi request reprint The prevalence of TT virus (TTV) infection and its relationship to hepatitis in children
    M Iriyama
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Med Microbiol Immunol 188:83-9. 1999
    ..The larger quantity of TTV-DNA in infants and the high prevalence of TTV in children of all ages suggest that TTV may be transmitted in early childhood. Its relationship to hepatitis is doubtful in children...
  92. ncbi request reprint Investigation of varicella-zoster virus DNA in lymphocyte subpopulations by quantitative PCR assay
    Y Ito
    Department of Pediatrics Developmental Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Microbiol Immunol 45:267-9. 2001
    ..The amount of viral DNA was similar in each PBMC subpopulation, suggesting that each lymphocyte fraction and monocytes carry similar amounts of VZV DNA during viremia...
  93. ncbi request reprint Varicella exposure in a neonatal medical centre: successful prophylaxis with oral acyclovir
    M Hayakawa
    Department of Pediatric Cardiology and Neonatology, Ogaki Municipal Hospital, Ogaki, Japan
    J Hosp Infect 54:212-5. 2003
    ....
  94. ncbi request reprint Prospective monitoring of the Epstein-Barr virus DNA by a real-time quantitative polymerase chain reaction after allogenic stem cell transplantation
    Y Hoshino
    Department of Paediatrics Developmental Paediatrics, Nagoya University School of Medicine, Nagoya, Japan
    Br J Haematol 115:105-11. 2001
    ..We propose that an EBV load > 10(2.5) copies/microg DNA is the reactivation of EBV, and that an EBV load > 10(4.0) copies/microg DNA is indicative of developing LPD...
  95. ncbi request reprint Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir
    Y Ito
    Department of Pediatrics, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Clin Infect Dis 30:185-7. 2000
    ..027). In conclusion, exacerbation of HSE in children may be more common than previously recognized. It is suggested that the replication of HSV or another viral pathogen caused a second encephalitic illness (HSE) in some cases...
  96. ncbi request reprint Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy
    Y Ito
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    J Med Virol 58:420-5. 1999
    ..Proinflammatory cytokines and soluble cytokine receptors may mediate the disease. The high plasma concentration of IL-6 could be an indicator of the progression to encephalopathy...
  97. ncbi request reprint CD4- and CD56-positive T-cell line, MTA, established from natural killer-like T-cell leukemia/lymphoma
    N Emi
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Int J Hematol 69:180-5. 1999
    ..The MTA cell line is a novel cell line with which to study NK-like T-cell ontogenecity...
  98. ncbi request reprint Natural killer cell proliferation and circulating cytokines in patients with bilateral basal ganglia calcification
    T Morishima
    Department of Health Science, Nagoya University School of Medicine, Japan
    Eur J Neurol 9:521-5. 2002
    ..In summary, NK cell propagation and circulating cytokines, particularly tumor necrosis factor-alpha, may be involved in the etiology of basal ganglia calcification...
  99. ncbi request reprint Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6
    Tetsushi Yoshikawa
    Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Med Virol 66:82-5. 2002
    ..In contrast to HHV-6, CMV DNAemia was detected in the terminal phase of the illness. Thus, HHV-6 reactivation may have been the cause of the severe lymphocyte depletion and fatal CMV infection...
  100. ncbi request reprint SH2D1A mutations in Japanese males with severe Epstein-Barr virus--associated illnesses
    R Sumazaki
    Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Japan
    Blood 98:1268-70. 2001
    ..Thus, genetic analysis of the SH2D1A gene is particularly useful in the diagnosis of sporadic cases and carriers of XLP. (Blood. 2001;98:1268-1270)..
  101. ncbi request reprint Association of transforming growth factor-beta1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases
    Kanako Hatta
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamigyo ku, Kyoto, Japan
    Haematologica 92:1470-4. 2007
    ..In this study, the pattern of cytokine gene polymorphisms was comparatively analyzed in EBV-related diseases...